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Abstract Background: Inflammation, which is associated with an unhealthy lifestyle, plays a critical role in the development of both cardiometabolic diseases (CMD) and cancer. Carcinoembryonic antigen (CEA) is a tumor marker which also has proinflammatory properties. Recent studies have reported CEA to be associated with atherosclerosis, metabolic syndrome, and visceral adiposity. Epicardial adipose tissue (EAT) can exhibit highly inflammatory and pathogenic properties, and is a known risk factor for CMD. However, its relationship with CEA is still unknown. Objectives: This study aimed to investigate the possible association of CEA with EAT. Methods: A total of 134 Caucasian (males = 56, females = 78) individuals, aged (22-83 years), who were admitted for routine health control, were enrolled in this cross-sectional study. CEA was measured with chemiluminescent microparticle immunoassay (CMIA). EAT was measured by transthoracic echocardiography, and the visceral fat rating (VFR) was assessed by a body composition analyzing machine. The p-value <0.05 was considered statistically significant. Results: CEA levels were categorized as tertiles: T1, 0.5-1.04; T2, 1.06–1.69; and T3, ≥1.7 ng/ml. The mean age, weight, VFR, EAT, and fasting glucose, as well as the median of systolic blood pressure (SBP), creatinine, and AST increased with the increasing CEA tertiles. CEA was significantly associated with EAT (r = 0.55, P<0.001) and VFR (r = 0.36, P<0.001). Multivariate linear regression analysis confirmed that gender, age, and EAT were the significant independent variables associated with CEA. Conclusion: Individuals with increased EAT have higher levels of CEA, suggesting that this biomarker is most likely produced by EAT; however, additional investigations are required to improve the present work. Background Inflammation lifestyle CMD (CMD cancer (CEA properties atherosclerosis syndrome adiposity (EAT However unknown Objectives Methods 13 males 56 78 individuals 2283 22 83 (22-8 years, years , years) control crosssectional cross sectional CMIA. CMIA . (CMIA) echocardiography (VFR machine pvalue p value 005 0 05 <0.0 Results tertiles T1 T 0.51.04 05104 0.5 1.04 5 1 04 0.5-1.04 T2 1.06–1.69 106169 06 69 T3 17 7 ≥1. ngml ng ml ng/ml age weight glucose SBP, SBP (SBP) creatinine r 055 55 0.55 P<0.001 P0001 P 001 036 36 0.36 P<0.001. gender Conclusion however work 228 2 8 (22- (CMIA 00 <0. 51 0.51.0 0510 0. 104 1.0 0.5-1.0 1.06–1.6 10616 6 ≥1 (SBP P<0.00 P000 03 3 0.3 (22 <0 0.51. 051 10 1. 0.5-1. 1.06–1. 1061 ≥ P<0.0 P00 (2 < 0.51 0.5-1 1.06–1 106 P<0. P0 ( 0.5- 1.06– P<0 1.06 P<