Abstract Objective: To conduct a cultural adaptation and validation of the DASH questionnaire to evaluate the perspective of patients with neurogenic disorders of the upper extremity regarding the impact on their quality of life. Method: We performed an adaptation of the Spanish version of the DASH questionnaire to the Mexican vocabulary and applied it to 478 volunteers. Ceiling effect, floor effect, item-total correlation, descriptive statistics of items and total score, internal consistency, precision, cross-sectional and longitudinal validity were estimated by comparing healthy controls and affected individuals with different disability levels. Results: Our DASH questionnaire version was equivalent to those previously approved and showed homogeneity of the items with respect to the total value of the questionnaire (Cronbach’s alpha > 0.96). In addition, it showed an accuracy of 7.25 points and the cross-sectional and longitudinal validity was documented with significant differences between groups and subgroups with distinct disability levels. Conclusions: The DASH questionnaire can be used with a high level of confidence in the Mexican population.

Resumen Objetivo: Realizar la adaptación cultural y validación del cuestionario DASH para conocer la perspectiva de pacientes con trastornos neurogénicos del miembro superior respecto al impacto en su calidad de vida. Método: Se realizó una adaptación al vocabulario mexicano de la versión española del cuestionario DASH y se aplicó en 478 voluntarios. Se estimaron el efecto techo, el efecto suelo, la correlación ítem-total, las medidas de tendencia central de ítems y el puntaje total, la consistencia interna, la precisión y la validez transversal y longitudinal mediante la comparación de individuos sanos y enfermos con diferente nivel de discapacidad. Resultados: Nuestra versión del cuestionario DASH resultó equivalente a las previamente aprobadas y mostró homogeneidad de los ítems respecto al valor total del cuestionario (alfa de Cronbach > 0.96). Además, tuvo una precisión de 7.25 puntos y se documentó la validez transversal y longitudinal con diferencias significativas entre grupos y subgrupos con diferente nivel de discapacidad. Conclusiones: El cuestionario DASH puede ser empleado con un nivel de confianza alto en la población mexicana.

Abstract We present the case of a 44 year old woman with systemic sclerosis who presented with intense abdominal pain without signs of peritonitis. An abdominal computed tomography showed generalized intestinal dilation, intestinal pneumatosis and an extensive pneumoperitoneum. A diagnostic laparoscopy was performed but no perforation nor gastrointestinal leakage were found. Spontaneous pneumoperitoneum in patients with systemic sclerosis without visceral perforation is an extremely rare complication. Physicians must have a low threshold of suspicion for this entity when a patient with systemic sclerosis presents with spontaneous pneumoperitoneum in the absence of peritoneal signs.

Resumen Presentamos el caso de una mujer de 44 años con diagnóstico de esclerosis sistémica, quien presentó dolor abdominal intenso sin datos de irritación peritoneal. Una tomografía computarizada de abdomen mostró dilatación generalizada de asas intestinales, neumatosis intestinal y neumoperitoneo extenso, por lo cual se realizó una laparoscopía diagnóstica, sin encontrar sitio de perforación. El neumoperitoneo espontáneo en pacientes con esclerodermia sin evidencia de perforación visceral es una complicación extremadamente rara. El médico deberá mantener un alto índice de sospecha para esta condición ante un paciente con esclerosis sistémica que se presente con un neumoperitoneo espontáneo sin datos de irritación peritoneal.

ABSTRACT: Retrospective studies that address the diseases in the feline species are scarce. Herein, we presented the cause of death or euthanasia of cats from January 2020 to December 2021, during the first and second years of the SARS-CoV-2 pandemic. The data were obtained from necropsies performed by the Federal Rural University of Rio de Janeiro and the Federal University of Mato Grosso. A total of 96 feline necropsies were performed. In 87 cases (90.6%), we established the reason for death, while in nine cases (9.4%), the diagnoses were inconclusive. We established the diagnostic groups: infectious and parasitic (37.5%), neoplasm (14.5%), malformation (7.3%), lower urinary tract disease (7.3%), degenerative (6.2%), traumas (6.2%), other causes (8.4%) and iatrogenic (3.1%). The most common cat diseases in Mato Grosso and Rio de Janeiro were infectious. The most common inflammatory lesions were bacterial and viral pneumonia. Alphaherpesvirus (FeHV), Mycoplasma sp., and Pseudomonas sp. were the main detected agents. ABSTRACT scarce Herein 202 2021 SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- pandemic 9 8 90.6%, 906 90.6% , 90 6 (90.6%) 9.4%, 94 9.4% 4 (9.4%) inconclusive groups 37.5%, 375 37.5% 37 5 (37.5%) 14.5%, 145 14.5% 14 (14.5%) 7.3%, 73 7.3% 7 3 (7.3%) 6.2%, 62 6.2% (6.2%) 8.4% 84 (8.4% 3.1%. 31 3.1% . 1 (3.1%) pneumonia FeHV, FeHV (FeHV) sp agents 20 SARS-CoV 90.6 (90.6% 9.4 (9.4% 37.5 (37.5% 14.5 (14.5% 7.3 (7.3% 6.2 (6.2% 8.4 (8.4 3.1 (3.1% (FeHV 90. (90.6 9. (9.4 37. (37.5 14. (14.5 7. (7.3 6. (6.2 8. (8. 3. (3.1 (90. (9. (37. (14. (7. (6. (8 (3. (90 (9 (37 (14 (7 (6 ( (3 (1

RESUMO: Estudos retrospectivos que abordam doenças em felinos domésticos são escassos. Apresentamos aqui a causa da morte ou razões para eutanásia de gatos domésticos entre janeiro de 2020 e dezembro de 2021, durante o primeiro e segundo ano da pandemia de SARS-CoV-2. Os dados foram obtidos em necropsias realizadas pela Universidade Federal Rural do Rio de Janeiro e Universidade Federal de Mato Grosso. Foram realizadas 96 necropsias de felinos. Em 87 casos (90,6%) foi estabelecido a causa da morte e em nove casos (9,4%) os diagnósticos foram inconclusivos. Estabelecemos os grupos diagnósticos: infecciosos e parasitários (37,5%), neoplasias (14,5%), malformações (7,3%), doenças do trato urinário inferior (7,3%), degenerativas (6,2%), traumas (6,2%), outras causas (8,4%) e iatrogênicas (3,1%). As doenças mais frequentes em gatos do Mato Grosso e Rio de Janeiro foram as infecciosas. As lesões inflamatórias mais frequentes foram as pneumonias bacterianas e virais. Os principais agentes detectados foram Alphaherpesvirus (FeHV), Mycoplasma sp. e Pseudomonas sp. RESUMO escassos 202 2021 SARSCoV2. SARSCoV2 SARSCoV SARS CoV 2. 2 SARS-CoV-2 9 8 90,6% 906 90 6 (90,6% 9,4% 94 4 (9,4% inconclusivos 37,5%, 375 37,5% , 37 5 (37,5%) 14,5%, 145 14,5% 14 (14,5%) 7,3%, 73 7,3% 7 3 (7,3%) 6,2%, 62 6,2% (6,2%) 8,4% 84 (8,4% 3,1%. 31 3,1% . 1 (3,1%) infecciosas virais FeHV, FeHV (FeHV) sp 20 SARS-CoV- 90,6 (90,6 9,4 (9,4 37,5 (37,5% 14,5 (14,5% 7,3 (7,3% 6,2 (6,2% 8,4 (8,4 3,1 (3,1% (FeHV SARS-CoV 90, (90, 9, (9, 37, (37,5 14, (14,5 7, (7,3 6, (6,2 8, (8, 3, (3,1 (90 (9 (37, (14, (7, (6, (8 (3, ( (37 (14 (7 (6 (3 (1

Resumen La reserva cognitiva (RC) se refiere al nivel de adaptabilidad de la cognición frente a cambios cerebrales. Varios estudios la han considerado un factor de protección de la enfermedad de Alzheimer (EA). En la región argentina no se cuenta con un instrumento validado que permita medir este constructo. El objetivo del presente trabajo es adaptar el Cuestionario de Reserva Cognitiva (CRC) a la población argentina, establecer puntajes de corte para determinar desde niveles bajos a superiores de RC y analizar qué variables predicen el puntaje total de la reserva. Las modificaciones introducidas a la adaptación fueron evaluadas a través de un proceso de juicio de expertos. Un total de 177 sujetos sanos completaron el Cuestionario de Reserva Cognitiva en su adaptación argentina (CRC-a). Mediante la medida de cuartiles, se establecieron puntajes de corte para determinar niveles bajos, medios, altos y superiores de la reserva. Se realizó una regresión lineal para evaluar si el sexo, la edad y la escolaridad predicen el nivel de RC. En la adaptación argentina del CRC se modificaron 3 de las 8 dimensiones totales y 16 de los 33 ítems totales con respecto al cuestionario original. La media del puntaje total obtenido por la muestra a partir del cuestionario fue de 15.06 con DS = 3.42. Puntajes menores a 13 reflejaron niveles bajos de RC, puntajes entre 13 y 16, niveles medios, puntajes entre 16 y 20, niveles altos, y puntajes superiores a 20, niveles superiores. La escolaridad resultó ser la única variable de predicción del nivel de RC. Si bien se encontraron diferencias entre grupos respecto a la variable sexo, esta no demostró ser predictiva. El CRC-a es el primer instrumento desarrollado en esta región para medir el nivel de RC. Contar con su validación abriría futuras líneas de investigaciones sobre posibles intervenciones para la prevención de enfermedades, tales como la EA.

Abstract Cognitive reserve (CR) refers to the level of adaptability of cognition after brain changes. It is based on processes that allow the activation of new synaptic connections after neurodegeneration, which permits to better withstand the consequences. This reserve is constituted by the interaction of innate individual characteristics (intrauterine or genetically determined) and the exposure to different life experiences. It begins its development in early stages of life and continues its transformation up to advances ages. The sociodemographic variables reported as the main ones to build the reserve are education, leisure activities, lifestyle, socioeconomic level and intelligence. Several studies have considered it as a protective factor for Alzheimer's Disease (AD). Subjects with high levels of CR have lower prevalence and incidence of AD in comparison to those with low levels of reserve. CR would lead to a late onset of symptoms, despite not having any effect on the underlying pathophysiological process of the disease. The reserve would not prevent AD from developing, but it would compensate the symptoms and, therefore, delay their onset. In some cases, there is such compensation that the symptoms do not manifest. There is no validated instrument available for the Argentinian region that allows to measure this construct. The aim of this study is to adapt the Cognitive Reserve Questionnaire to the Argentinian population, to establish cut-off scores to distinguish between low, medium, high and superior levels of CR and analyze which variables could predict the total reserve score. The modifications introduced in the adaptation were evaluated through an expert judgment process. A total of 177 healthy subjects completed the Cognitive Reserve Questionnaire in its Argentinian adaptation (CRQ-a). Through the measure of quartiles, cut-off scores were established to determine low, medium, high and superior levels of the reserve. A lineal regression was made to evaluate if age, education, and sex might predict the level of CR. Three of the eight total dimensions and 16 of the 33 total items that make up the original questionnaire were modified. The mean of the total score obtained by the sample from the questionnaire was 15.06 with SD = 3.42. Scores under 13 reflected low CR levels, scores between 13 and 16 reflected medium levels, scores between 16 and 20 reflected high levels, and scores above 20 reflected superior levels. Education turned out to be the only predictor variable for the level of CR. Although differences were found between groups of different sex, this variable turned out to be not predictive. The CRQ-a is the first instrument for the Argentinian population to measure the level of the reserve. It allows to quickly explore different dimensions, considered as the most relevant for its formation. These are: formal education, courses, parents' formal education, employment, musical training, languages, reading activity and intellectual games. In patients with AD, is particularly important to have a measure for CR to prepare interventions for those subjects whose reserve levels are perceived as low, aiming to delay and, when possible, prevent the clinical manifestation of the disease. Its validation would open future lines of research on possible interventions for the prevention of diseases such as AD.

Resumen Determinar la precisión del método de Kvaal en la estimación de la edad dental mediante el análisis de radiografías panorámicas digitales de pacientes entre 20 a 47 años atendidos en la clínica estomatológica de la Universidad Científica del Sur, (2018 a 2019), Lima-Perú. Se analizaron 289 radiografías panorámicas digitales pertenecientes a individuos de ambos sexos, de 20 a 47 años. Se obtuvo medidas de longitud y anchura en la cámara dental y pulpar en los incisivos centrales superiores. Estos datos se valoraron posteriormente al calcular las proporciones entre la pulpa y longitud de la raíz del incisivo central superior aplicando la fórmula del método de Kvaal et al. para obtener la precisión del método en la estimación de la edad dental. Al aplicar la fórmula de Kvaal et al. indica que la relación entre la anchura de pulpa y la longitud de la raíz presentan un nivel de significancia mayor en relación a otras proporciones: M valor medio de todas las proporciones excepto T (-0.659) y W-L: diferencia entre los valores de W y L (-0.643). El coeficiente de determinación (r²) y el error estándar de la estimación (SEE) utilizando la fórmula original de Kvaal es de r²: 0.70, SEE: 4.90 años, después se propuso una fórmula modificada de Kvaal para la población peruana. El Método de Kvaal et al. tiene una precisión del 1.24 en la estimación de la edad dental de los individuos, utilizando el incisivo central superior en radiografías panorámicas digitales.

Abstract To determine the accuracy of the Kvaal method in the estimation of dental age through the analysis of digital panoramic radiographs of patients between 20 and 47 years of age who attended the stomatological clinic of the Universidad Científica del Sur, (2018 to 2019), Lima-Perú. 289 digital panoramic radiographs belonging to individuals of both sexes, aged 20 to 47 years were analyzed. Length and width measurements were obtained in the dental and pulp chamber in the upper central incisors. These data were subsequently evaluated by calculating the proportions between the pulp and root length of the upper central incisor by applying the formula of the method of Kvaal et al. to obtain the accuracy of the method in estimating dental age. Applying the formula of Kvaal et al. indicates that the relationship between the width of the pulp and the length of the root has a higher level of significance in relation to others proportions: M mean value of all ratios except T (-0.659) and W-L difference between W and L (-0.643). The coefficient of determination (r²) and standard error of estimation (SEE) using the original Kvaal formula is r²: 0.70, SEE: 4.90 years, then a modified Kvaal formula was proposed for the Peruvian population. The Method of Kvaal et al. has an accuracy of 1.24 in estimating the dental age of individuals, using the upper central incisor in digital panoramic radiographs.

Abstract Introduction: Congenital heart diseases are the most common congenital disorders in the world population, they generally manifest after birth. Altitudes between 2,500-3,500 meters above sea level have been linked to the high incidence of congenital heart diseases such as patent ductus arteriosus, atrial septum defects, and ventricular septum defects. Objetives: To characterize clinically and sociodemographically the patients diagnosed with congenital heart disease from low, moderate and high altitudes in a regional hospital in Colombia. Methodology: Observational, descriptive retrospective study. All patients under 18 years of age with a diagnosis of congenital heart disease, treated at the San Rafael de Tunja University Hospital between 2015 and 2021, were included. Results: 51.9% of the patients were male, 16.3% had a history of prematurity and 9.1% had a diagnosis of Down syndrome. The most frequent heart diseases were: persistent ductus arteriosus 35.1%, followed by ventricular communication representing 21.6% and intra-atrial communication with 19.7%). Conclusions: They must eestablish strategies such as screening and timely diagnosis of congenital heart disease in at-risk populations in order to improve the life prognosis of patients and the outcome of the disease.

Resumen Introducción: Las cardiopatías congénitas son los trastornos congénitos más frecuentes en la población mundial, se manifiestan generalmente después del nacimiento. Las altitudes entre 2,500 y 3,500 metros sobre el nivel del mar se han relacionado con la alta incidencia de cardiopatías congénitas como el ductus arterioso persistente, los defectos del septum auricular y los defectos del septum ventricular. Objetivo: Caracterizar clínica y sociodemográficamente los pacientes con diagnóstico de cardiopatías congénitas procedentes de altitudes bajas, moderadas y altas en un hospital regional de Colombia. Metodología: Estudio observacional, descriptivo retrospectivo. Se incluyeron todos los pacientes menores de 18 años con diagnóstico de cardiopatías congénitas, atendidos en el Hospital Universitario San Rafael de Tunja entre el 2015 y 2021. Resultados: El 51.9% de los pacientes eran de sexo masculino, el 16.3% tenían antecedente de prematurez y el 9.1% tenían diagnóstico de síndrome de Down. Las cardiopatías más frecuentes fueron: ductus arterioso persistente (35.1%), seguido de comunicación interventricular (21.6%) y comunicación intrauricular (19.7%). Conclusiones: Se deben establecer estrategias como el tamizaje y diagnóstico oportuno de las cardiopatías congénitas en poblaciones de riesgo con el fin de mejorar el pronóstico de vida de los pacientes y desenlace de la enfermedad.

Abstract For Paul Gilroy, Henry Louis Gates Jr. and others, Raymond Williams embraced notions of cultural authenticity and ethnic continuity compatible with the racisms of the Right. This influential critique is based on a fundamental misreading of Williams’ position. This text explores notions of identity in Williams’ criticism and novels to offer an alternative reading. Although often dismissed as a white, male, English critic, and a member of the dominant sector within British society, Williams was in fact Welsh and meditated throughout his life on the meaning of that identity. He never endorsed forms of British superiority and exceptionalism, since he noted explicitly in Politics and Letters (1979) that he never considered himself to be British. Furthermore, Williams consistently rejected racial and blood-based forms of identity and emphasized how his marginal formation on the Wales-England border led to an awareness of the always evolving and historically contingent nature of communal identification. Gilroy Jr others Right position reading white male critic society exceptionalism 1979 (1979 Furthermore bloodbased blood WalesEngland Wales England identification 197 (197 19 (19 1 (1 (

Resumo Segundo Paul Gilroy, Henry Louis Gates Jr., entre outros, Raymond Williams teria abraçado noções de autenticidade cultural e continuidade étnica comparáveis aos racismos da direita. Essa crítica influente se baseia em uma má interpretação da posição de Williams. O presente texto explora noções de identidade na crítica e nos romances de Williams para oferecer uma leitura alternativa. Embora frequentemente dispensado como um crítico inglês, branco, homem e membro do setor dominante da Grã-Bretanha, Williams era de fato galês e meditou ao longo de sua vida a respeito do significado dessa identidade. Jamais apoiou formas de superioridade ou excepcionalismo britânico, já que pontuou explicitamente em Politics and Letters (1979) que nunca se considerou britânico. Ademais, Williams rejeitou consistentemente formas de identidade racial e sanguíneas e enfatizou como sua formação marginal na fronteira País de Gales-Inglaterra o levou a uma conscientização do carácter sempre em evolução e historicamente contingente da identificação comunitária. Gilroy Jr Jr. outros direita alternativa inglês branco GrãBretanha, GrãBretanha Grã Bretanha, Bretanha Grã-Bretanha britânico 1979 (1979 Ademais GalesInglaterra Gales Inglaterra comunitária 197 (197 19 (19 1 (1 (

ABSTRACT: Spirorchidiasis is one of the most common diseases in green turtles. Eggs and the adult form of trematodes are mainly found in the heart, liver, lung, spleen, and gastrointestinal tract. The present study aimed to describe the pathological aspects of Spirorchiidae trematode infection in green turtles (Chelonia mydas) in the Campos Basin, Rio de Janeiro. The current study was based on the necropsy of 99 green turtles (Chelonia mydas, Chelonidae) from April to December 2021. Epidemiological data were obtained from the Aquatic Biota Monitoring Information System (SIMBA). A histopathological examination was performed at the “Setor de Anatomia Patológica” (SAP) from “Universidade Federal Rural do Rio de Janeiro” (UFRuralRJ). Tissue fragments (buccal papilla, esophagus, trachea, lung, heart, kidney, bladder, stomach, liver, spleen, intestines, gonads, adrenal, thyroid, pancreas, salt glands, muscle, and skin) were sampled for histological examination. The green turtles had lesions compatible with parasitic infection in 89% (88/99) cases. Out of 88 turtles, 87 were juveniles (99%), 75% (66/88) were females, and 25% (22/88) were males. Adult parasites and their eggs were found to cause granulomatous tissue reactions in 14% (12/88) of turtles. Egg-associated granulomatous inflammation was found in 86% (76/88) of the turtles. The organs with the highest number of egg-associated granulomas in order of occurrence were: the spleen, small intestine, adrenal gland, pancreas, and lungs. The adult trematodes were observed in histological lesions in order of occurrence, mainly in the esophagus, stomach, and small intestine. Out of the total number of turtles parasitized, 33% (29/88) of deaths occurred due to multiple causes such as fractures, interaction with fishing, predation, and fibropapillomas. The other 67% (59/88) presented multisystemic granulomatous disease caused by Spirorchiidae infection as a cause of death. Evidence is presented that spirorchidiasis is highly prevalent in young green turtles, is responsible for extensive chronic lesions, and responsible for significant debilitation and mortality. ABSTRACT heart liver lung spleen tract Chelonia mydas Basin Janeiro 9 Chelonidae 2021 SIMBA. SIMBA . (SIMBA) Setor Patológica SAP (SAP Universidade UFRuralRJ. UFRuralRJ (UFRuralRJ) buccal papilla esophagus trachea kidney bladder stomach intestines gonads thyroid pancreas glands muscle skin 89 88/99 8899 (88/99 cases 8 99%, 99% , (99%) 75 66/88 6688 66 (66/88 females 25 22/88 2288 22 (22/88 males 14 12/88 1288 12 (12/88 Eggassociated Egg associated 86 76/88 7688 76 (76/88 eggassociated egg intestine gland lungs parasitized 33 29/88 2988 29 (29/88 fractures fishing predation fibropapillomas 67 59/88 5988 59 (59/88 death mortality 202 (SIMBA (UFRuralRJ 88/9 889 (88/9 (99% 7 66/8 668 6 (66/8 2 22/8 228 (22/8 1 12/8 128 (12/8 76/8 768 (76/8 3 29/8 298 (29/8 59/8 598 5 (59/8 20 88/ (88/ (99 66/ (66/ 22/ (22/ 12/ (12/ 76/ (76/ 29/ (29/ 59/ (59/ (88 (9 (66 (22 (12 (76 (29 (59 (8 ( (6 (2 (1 (7 (5

RESUMO: A espirorquidíase é uma das doenças mais comuns em tartarugas verdes. Os ovos e a forma adulta dos trematódeos são encontrados principalmente no coração, fígado, pulmão, baço e trato gastrointestinal. O objetivo do presente estudo foi descrever os aspectos patológicos da infecção por trematódeos Spirorchiidae em tartarugas verdes (Chelonia mydas) na Bacia de Campos, Rio de Janeiro. O presente trabalho foi baseado na necropsia de 99 tartarugas verdes (Chelonia mydas, Chelonidae) no período de abril a dezembro de 2021. Os dados epidemiológicos foram obtidos do Sistema de Informação de Monitoramento da Biota Aquática (SIMBA). Realizou-se exame histopatológico no Setor de anatomia Patológica (SAP) da Universidade Federal Rural do Rio de Janeiro (UFRuralRJ). Os fragmentos de tecidos (papila bucal, esôfago, traqueia, pulmão, coração, rim, bexiga, estômago, fígado, baço, intestinos, gônadas, adrenal, tireoides, pâncreas, glândulas de sal, músculo e pele) foram coletados e fixados em formalina a 10% tamponada, processados rotineiramente para exame histológico. Em 89% (88/99) dos casos, as tartarugas-verdes apresentaram lesões compatíveis com infecção parasitária. Das 88 tartarugas, 87 eram jovens (99%), 75% (66/88) correspondiam a fêmeas, 25% (22/88) a machos. Em 14% (12/88) das tartarugas foram encontrados parasitas adultos e seus ovos causando inflamação granulomatosa. Em 86,4% (76/88) das tartarugas foram encontradas lesões granulomatosas associadas aos ovos dos trematódeos. Os órgãos com maior quantidade de granulomas associados a ovos foram: baço, intestino delgado, adrenal, pâncreas e pulmões. Trematódeos adultos foram principalmente observados nas lesões histológicas, em ordem de ocorrência, no esôfago, estômago e intestino delgado. Do total de tartarugas parasitadas, 33% (29/88) das mortes ocorreram em consequência de múltiplas causas como fraturas, interação com pesca, predação e fibropapilomas. As outras 67% (59/88) apresentaram como causa de morte a doença granulomatosa multissistêmica causada pela infecção por trematódeo da família Spirorchiidae. São apresentadas evidências de que a espiroquidiase é altamente prevalente em tartarugas verdes jovens no Rio de Janeiro, responsável por extensas lesões crônicas, quadro clínico de debilidade e mortalidade significativas. RESUMO coração fígado pulmão gastrointestinal Chelonia mydas Campos 9 Chelonidae 2021 SIMBA. SIMBA . (SIMBA) Realizouse Realizou se SAP (SAP UFRuralRJ. UFRuralRJ (UFRuralRJ) papila bucal esôfago traqueia rim bexiga intestinos gônadas adrenal tireoides sal pele 10 tamponada histológico 89 88/99 8899 (88/99 casos tartarugasverdes parasitária 8 99%, 99% , (99%) 75 66/88 6688 66 (66/88 fêmeas 25 22/88 2288 22 (22/88 machos 14 12/88 1288 12 (12/88 864 86 4 86,4 76/88 7688 76 (76/88 delgado pulmões histológicas ocorrência parasitadas 33 29/88 2988 29 (29/88 fraturas pesca fibropapilomas 67 59/88 5988 59 (59/88 crônicas significativas 202 (SIMBA (UFRuralRJ 1 88/9 889 (88/9 (99% 7 66/8 668 6 (66/8 2 22/8 228 (22/8 12/8 128 (12/8 86, 76/8 768 (76/8 3 29/8 298 (29/8 59/8 598 5 (59/8 20 88/ (88/ (99 66/ (66/ 22/ (22/ 12/ (12/ 76/ (76/ 29/ (29/ 59/ (59/ (88 (9 (66 (22 (12 (76 (29 (59 (8 ( (6 (2 (1 (7 (5

ABSTRACT: We report a case of a free-ranging five-month wildcat with bilateral hind limbs paralysis since birth due to a segmental lumbar spinal cord aplasia. The species confirmation of the southern tiger cat (Leopardus guttulus) was determined by genetic sequencing. This southern tiger cat native to Brazil had autophagy in both pelvic limbs during the initial phase of hospitalization, followed by a right tibial fracture with bone exposition. Euthanasia was chosen due to animal welfare and submitted for postmortem examination. Grossly, there was an 8.5cm in-length segmental interruption of the spinal cord between the third and fifth lumbar vertebrae, with a lack of spinal cord tissue and collapsed associated dura mater. Microscopically, the representative sections of the L3 to L5 spinal cord had only .an irregular trace of gray matter adhered to the meninges (lumbar spinal cord aplasia) In the region of L6, a focally extensive, cystic, and well-defined tubular cavitation was noted dorsally to the central canal, replacing and compressing the adjacent nervous tissue (syringomyelia). Metagenomics examination did not detect any virus responsible for the presented spinal cord malformations. This seems to be the first description of segmental spinal cord aplasia reported in a wild feline. ABSTRACT freeranging free ranging fivemonth five month Leopardus guttulus sequencing hospitalization exposition Grossly 85cm cm 8 5cm inlength length vertebrae mater Microscopically L L6 extensive cystic welldefined well defined canal syringomyelia. syringomyelia . (syringomyelia) malformations feline (syringomyelia

RESUMO: O objetivo do presente relato foi descrever um caso de aplasia segmentar da medula espinhal lombar em um felino silvestre, com aproximadamente cinco meses, resgatado de seu ambiente natural, apresentando paralisia bilateral dos membros posteriores. A espécie gato-do-mato-pequeno (Leopardus guttulus) foi determinada por sequenciamento genético. Após curto período de hospitalização, iniciou autofagia de ambos os membros pélvicos, seguido de fratura com exposição óssea. Optou-se pela eutanásia e o cadáver foi encaminhado ao Setor de Anatomia Patológica da Universidade Federal Rural do Rio de Janeiro para necropsia. Macroscopicamente, havia uma interrupção segmentar grave da medula espinhal entre a terceira e a quinta vértebras lombares, medindo 8,5cm de comprimento, com resquícios de tecido nervoso e com meninges colapsadas. Ao exame histológico, em seções da medula espinhal na região de L3 a L5, .havia apenas vestígio de tecido nervoso aderido às meninges, morfologicamente compatível com substância cinzenta (aplasia de medula espinhal lombar). Na região de L6 notou-se áreas multifocais com cavitações tubulares, císticas e bem delimitadas, dorsalmente ao canal central substituindo e comprimindo o tecido nervoso adjacente (siringomielia). O exame de metagenômica não detectou qualquer vírus responsável pelas malformações da medula espinhal. Com base no histórico, sinais clínicos, necropsia e achados histológicos, o diagnóstico de aplasia segmentar grave com siringomielia foi estabelecido em um L. guttulus. RESUMO silvestre meses natural posteriores gatodomatopequeno gato mato pequeno Leopardus guttulus genético hospitalização pélvicos óssea Optouse Optou se Macroscopicamente lombares 85cm cm 8 5cm comprimento colapsadas histológico L L5 lombar. . lombar) notouse notou tubulares delimitadas siringomielia. (siringomielia) histórico clínicos histológicos (siringomielia

ABSTRACT: Mesotheliomas in cattle are often described as isolated case reports, and investigations of multiple cases within the same bovine herd are lacking. A series of cases of malignant epithelial mesothelioma, tubulopapilary type, is described in five 15 to 21-year-old Red Sindhi cows from the same herd. Clinical signs included three to eight months of progressive emaciation, dehydration, subcutaneous edema of the lower extremities, and abdominal distension. Grossly, severe subcutaneous edema and hydroperitoneum were noted. Multiple organs’ parietal and visceral serosal surfaces had multifocal to coalescing yellow, firm, sessile nodules ranging from 0.1 to 29.0cm. Similar free nodules floated in the peritoneal fluid. Histologically, the masses comprised a layer of cubic to columnar neoplastic cells forming papillary or cystic proliferation supported by a dense fibrovascular stroma. Neoplastic cells had strong and diffuse cytoplasmic immunolabeling for pan-cytokeratin but were negative for cytokeratin 7 and vimentin. Ultrastructurally, neoplastic cells had delicate microvilli and tight and anchoring junctions. Within the cytoplasm, a moderate amount of loose aggregate of intermediary filament with small mitochondria was observed. Epidemiological investigation evidenced endogamy in this herd. Asbestos exposure was not detected. The diagnosis was based on clinical, gross, histological, and immunohistochemical findings and confirmed by transmission electron microscopy features. A definitive underlying etiology remains unknown. ABSTRACT reports lacking mesothelioma type 1 21yearold yearold 21 year old emaciation dehydration extremities distension Grossly noted organs yellow firm 01 0 0. 290cm cm 29 0cm 29.0cm fluid Histologically stroma pancytokeratin pan vimentin Ultrastructurally junctions cytoplasm observed detected clinical gross histological features unknown 2

RESUMO: Mesotelioma em bovinos são frequentemente relatados como casos isolados, descrições de múltiplos casos no mesmo rebanho bovino não foram encontrados. Descreve-se uma série de casos de mesotelioma epitelial maligno, tipo tubulopapilar, em cinco vacas Red Sindi de 15 a 21 anos de idade do mesmo rebanho. Os sinais clínicos incluíram emagrecimento progressivo, desidratação, edema subcutâneo das extremidades dos membros e distensão abdominal em um curso clínico que variou de três a oito meses. Macroscopicamente, observou-se edema subcutâneo acentuado e hidroperitônio. Nas serosas parietais e viscerais de múltiplos órgãos haviam nódulos multifocais a coalescentes amarelo-claros, firmes e sésseis que variavam de 0,1 a 29,0 centímetros de diâmetro. Nódulos livres semelhantes também flutuavam no líquido peritoneal. Histologicamente, as massas eram compostas por uma camada de células cúbicas a colunares formando proliferação papilar ou cística sustentada por estroma fibrovascular denso. As células neoplásicas apresentavam imunomarcação citoplasmática forte e difusa para pan-citoqueratina, mas eram negativas para citoqueratina 7 e vimentina. Ultraestruturalmente, as células neoplásicas apresentavam delicadas microvilosidades e junções comunicantes e de ancoragem. No citoplasma observou-se moderada quantidade de agregados de filamentos intermediários soltos e pequenas mitocôndrias. A investigação epidemiológica revelou que não houve inserção de bovinos de outros rebanhos por mais de 30 anos e evidenciou endogamia. Não foram encontradas possíveis fontes de amianto para os bovinos deste rebanho. O diagnóstico de mesotelioma foi baseado em características clínicas, macroscópicas, histológicas, imuno-histoquímicas e confirmado pelos achados de microscopia eletrônica. A etiologia permanece desconhecida. RESUMO isolados encontrados Descrevese Descreve se maligno tubulopapilar 1 2 progressivo desidratação meses Macroscopicamente observouse observou hidroperitônio amareloclaros, amareloclaros amarelo claros, claros amarelo-claros 01 0 0, 290 29 29, diâmetro peritoneal Histologicamente denso pancitoqueratina, pancitoqueratina pan citoqueratina, pan-citoqueratina vimentina Ultraestruturalmente ancoragem mitocôndrias 3 endogamia clínicas macroscópicas histológicas imunohistoquímicas imuno histoquímicas eletrônica desconhecida

Resumen Objetivo: A pesar de los esfuerzos para reducir la desigualdad de género, el sexismo persiste. Todavía son escasos los estudios sobre este fenómeno que contemplen variables como el deseo sexual o los antecedentes migratorios. El objetivo del estudio es analizar las circunstancias sociales (individuales y del contexto inmediato) asociadas al sexismo y su relación con la conducta violenta en la pareja en población adolescente. Método: Estudio transversal con 1421 estudiantes de 13 a 17 años de Alicante y Terrassa (2019-2020). El sexismo se midió mediante el Ambivalent Sexism Inventory, que valora el sexismo ambivalente, hostil y benevolente. Se utilizaron modelos lineales generalizados estratificados por sexo para identificar variables asociadas al sexismo, y regresión logística para analizar la asociación del sexismo con la conducta violenta en la pareja. Resultados: La probabilidad de puntuar alto en sexismo ambivalente fue mayor en migrantes (chicas y chicos: p <0,01) e hijos/as de migrantes (chicas: p <0,01; chicos: p <0,05). El deseo no heterosexual se asoció negativamente con el sexismo en chicas (benevolente: p <0,01) y en chicos (ambivalente y hostil: p <0,01; benevolente: p <0,05). El sexismo hostil mostró asociación con cometer violencia de pareja, independientemente del resto de las variables, tanto en chicas (odds ratio [OR]: 1,07; intervalo de confianza del 95% [IC95%]: 1,00-1,14) como en chicos (OR: 1,11; IC95%: 1,03-1,20). Conclusiones: El sexismo está presente entre adolescentes y se confirma su relación con la conducta violenta en la pareja. El deseo sexual y los antecedentes migratorios son variables a tener en cuenta en su prevención.

Abstract Objective: Despite the efforts to reduce gender inequality, sexism persists. There are still few studies on this matter that consider variables such as sexual desire or migration background. The aim of this study is to analyse the social circumstances (individual and from the immediate context) associated with sexism as well as its relationship with intimate partner violence perpetration amongst adolescents. Method: Cross-sectional study with 1421 students aged 13-17 from Alicante and Terrassa (2019-2021). Sexism was measured with the Ambivalent Sexism Inventory, which assesses ambivalent, hostile and benevolent sexism. Generalized linear models were carried out and stratified by sex to identify variables associated with sexism. A logistic regression model was used to assess the association between sexism and intimate partner violence. Results: The likelihood of a high score in ambivalent sexism was higher in migrants (girls and boys: p<0.01) and adolescents with migrant parents (girls: p<0.01; boys: p<0.05). Non-heterosexual desire was negatively associated with sexism in girls (benevolent: p<0.01) and boys (ambivalent and hostile: p<0.01; benevolent: p<0.05). Hostile sexism showed association with intimate partner violence perpetration, independently of the rest of the adjustment variables included in the model, for both girls (odds ratio [OR]: 1.07; 95% confidence interval [95% CI]: 1.00-1.14) and boys (OR: 1.11; 95% CI: 1.03-1.20). Conclusions: Sexism is present amongst teenagers and its relationship with intimate partner violence is confirmed. Sexual desire and migration background should be taken into account for intimate partner violence prevention.

Resumen Objetivo: A pesar de los esfuerzos para reducir la desigualdad de género, el sexismo persiste. Todavía son escasos los estudios sobre este fenómeno que contemplen variables como el deseo sexual o los antecedentes migratorios. El objetivo del estudio es analizar las circunstancias sociales (individuales y del contexto inmediato) asociadas al sexismo y su relación con la conducta violenta en la pareja en población adolescente. Método: Estudio transversal con 1421 estudiantes de 13 a 17 años de Alicante y Terrassa (2019-2020). El sexismo se midió mediante el Ambivalent Sexism Inventory, que valora el sexismo ambivalente, hostil y benevolente. Se utilizaron modelos lineales generalizados estratificados por sexo para identificar variables asociadas al sexismo, y regresión logística para analizar la asociación del sexismo con la conducta violenta en la pareja. Resultados: La probabilidad de puntuar alto en sexismo ambivalente fue mayor en migrantes (chicas y chicos: p <0,01) e hijos/as de migrantes (chicas: p <0,01; chicos: p <0,05). El deseo no heterosexual se asoció negativamente con el sexismo en chicas (benevolente: p <0,01) y en chicos (ambivalente y hostil: p <0,01; benevolente: p <0,05). El sexismo hostil mostró asociación con cometer violencia de pareja, independientemente del resto de las variables, tanto en chicas (odds ratio [OR]: 1,07; intervalo de confianza del 95% [IC95%]: 1,00-1,14) como en chicos (OR: 1,11; IC95%: 1,03-1,20). Conclusiones: El sexismo está presente entre adolescentes y se confirma su relación con la conducta violenta en la pareja. El deseo sexual y los antecedentes migratorios son variables a tener en cuenta en su prevención.

Abstract Objective: Despite the efforts to reduce gender inequality, sexism persists. There are still few studies on this matter that consider variables such as sexual desire or migration background. The aim of this study is to analyse the social circumstances (individual and from the immediate context) associated with sexism as well as its relationship with intimate partner violence perpetration amongst adolescents. Method: Cross-sectional study with 1421 students aged 13-17 from Alicante and Terrassa (2019-2021). Sexism was measured with the Ambivalent Sexism Inventory, which assesses ambivalent, hostile and benevolent sexism. Generalized linear models were carried out and stratified by sex to identify variables associated with sexism. A logistic regression model was used to assess the association between sexism and intimate partner violence. Results: The likelihood of a high score in ambivalent sexism was higher in migrants (girls and boys: p<0.01) and adolescents with migrant parents (girls: p<0.01; boys: p<0.05). Non-heterosexual desire was negatively associated with sexism in girls (benevolent: p<0.01) and boys (ambivalent and hostile: p<0.01; benevolent: p<0.05). Hostile sexism showed association with intimate partner violence perpetration, independently of the rest of the adjustment variables included in the model, for both girls (odds ratio [OR]: 1.07; 95% confidence interval [95% CI]: 1.00-1.14) and boys (OR: 1.11; 95% CI: 1.03-1.20). Conclusions: Sexism is present amongst teenagers and its relationship with intimate partner violence is confirmed. Sexual desire and migration background should be taken into account for intimate partner violence prevention.