Abstract The Internet is a growing source of knowledge and can provide information about oral health. This ecological study aimed to characterize the interests in toothpaste among Google users from different countries. Our hypothesis was that there would be an increase in Google users’ interest in information about toothpaste. This retrospective longitudinal ecological study analyzed the toothpaste-related interest of Google users from 10 countries between January 2004 and December 2020. The monthly variation in relative search volume (RSV) and the main related queries were determined using Google Trends. Autoregressive integrated moving average (ARIMA) forecasting models were built to establish the predictive RSV values for toothpaste for an additional 12 months. Autocorrelation plots and the generalized additive model (GAM) were used to diagnose trends and seasonality in RSV curves. Additionally, the influence of social isolation related to the outbreak of COVID-19 was analyzed. Although not detected by autocorrelation function (ACF) and partial autocorrelation function (PACF) analyses, the heuristic analysis showed an increase in the interest in toothpaste-related information in all countries, with a stable trend observed in the 12-month forecasts, except for the increases in the United Kingdom and South Africa. Also, GAM analyses demonstrated a non-significant monthly or quarterly seasonal influence on data. In addition, social isolation during the COVID-19 pandemic did not influence the online information-seeking behavior of Google Search users linked to this topic. We confirmed the hypothesis that the interest of Google Search users in information about toothpaste increased in all of the 10 assessed countries. health toothpasterelated 1 200 2020 (RSV Trends ARIMA (ARIMA months (GAM curves Additionally COVID19 COVID 19 COVID-1 ACF (ACF PACF (PACF 12month month forecasts Africa Also nonsignificant non significant data addition informationseeking seeking topic 20 202 COVID1 COVID- 2

Objectives: To assess the oral health of patients waiting for a liver transplantation. Material and Methods: A total of 103 cirrhotic patients were evaluated for socio-demographic characteristics and medical history of liver cirrhosis (etiology, time of inclusion in the transplant list, MELD - Model for End Liver Disease - value, complications of cirrhosis and routine medications in use). In addition, simplified oral hygiene index (IHO-S), dental caries index (DMFT) and sialometry were performed to verify oral health. After tabulation of the data, descriptive analyzes were performed. Results: The mean age was 54 years, the male gender was the most prevalent and the elementary school was completed by only 44% of the studied population. Hepatitis C and alcoholic cirrhosis were the etiologies that, more frequently, led the patients to indication for liver transplantation. Esophageal varices, ascites and portal hypertension were the complications of cirrhosis most observed. The mean DMFT of the studied population was considered high (23.3 ). Conclusions: The oral health of cirrhotic patients in the waiting list for transplantation is not satisfactory. Longitudinal studies are needed to investigate the relationship between foci of oral infections and the occurrence of infections post-transplant liver.

Objetivo: Evaluar la salud bucal de pacientes con cirrosis hepática en fila de trasplante. Material y Métodos: Fueron evaluados 103 pacientes cirróticos en cuanto a las características sociodemográficas e historial médico de cirrosis hepática (etiología, tiempo de inclusión en fila de trasplante, valor del MELD - Model for End-Stage Liver Disease, complicaciones de la cirrosis y medicaciones en uso). Así mismo fueron realizados los siguientes índices para evaluación de la salud bucal: índice de higiene oral simplificado (IHO-S), índice de caries dental (CPOD) y sialometría. Fueron realizados análisis descriptivos después de la tabulación de datos. Resultados: La población estudiada presentaba edad media de 54 años, el sexo masculino era el más prevalente y sólo el 44% concluyeran la educacion fundamental. La hepatitis C y la cirrosis alcohólica fueron las etiologias que con más frecuencia, llevaron a los pacientes a indicación de trasplante hepático. Las complicaciones de la cirrosis más observadas fueron várices esofágicas, ascitis e hipertensión portal. El CPOD medio de la población estudiada fue considerado alto, comparado con personas normoreactivas del mismo grupo etáreo (23,3 y 16,75 respectivamente ). Conclusiones: La salud bucal de pacientes cirroticos en fila de trasplante no es satisfactoria. Estudios longitudinales son necesarios para investigar la relación entre focos de infección bucal y la ocurrencia de infecciones en el post transplante hepático.

Objetivo: Avaliar a saúde bucal de pacientes com cirrose hepática em fila de transplante. Materiais e Método: Foram avaliados 103 pacientes cirróticos quanto às características sócio-demográficas e histórico médico da cirrose hepática (etiologia, tempo de inclusão na fila de transplante, valor do MELD - Model for End-Stage Liver Disease, complicações da cirrose e medicações em uso). A avaliação da saúde oral foi feita através do índice de higiene oral simplificado (IHO-S), do índice de cárie dental (CPOD) e da sialometria. Foram realizadas análises descritivas após a tabulação dos dados. Resultados: A população estudada apresentava idade média de 54 anos, o sexo masculino era o mais prevalente e apenas 44% concluíram o ensino fundamental. Hepatite C e cirrose alcoólica foram as etiologias que, com mais frequência, levaram os pacientes a indicação de transplante hepático. Varizes esofágicas, ascite e hipertensão portal foram as complicações mais frequentes. O CPOD médio da população estudada foi considerado alto (23,3). Conclusão: A saúde bucal de pacientes cirróticos em fila de transplante não é satisfatória. Estudos longitudinais são necessários para investigar a relação entre focos de infecção oral e a ocorrência de infecções no pós-transplante hepático.