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Joint statement on evidence-based practices in mechanical ventilation: suggestions from two Brazilian medical societies
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Ferreira, Juliana Carvalho

; Vianna, Arthur Oswaldo de Abreu

; Pinheiro, Bruno Valle

; Maia, Israel Silva

; Baldisserotto, Sérgio Vasconcellos

; Isola, Alexandre Marini

; Cavalcanti, Alexandre Biasi Gama, Ana Maria Casati Nogueira da Rocha, Angelo Roncalli Miranda Oliveira, Antonio Gonçalves de Serpa Neto, Ary Farias, Augusto Manoel de Carvalho Orlando, Bianca Rodrigues Esteves, Bruno da Costa Mazza, Bruno Franco Silveira, Camila de Freitas Martins Soares Carvalho, Carlos Roberto Ribeiro de Toufen Junior, Carlos Barbas, Carmen Silvia Valente Teixeira, Cassiano Silveira, Débora Dutra da Medeiros, Denise Machado Parolo, Edino Costa, Eduardo Leite Vieira Caser, Eliana Bernadete Oliveira, Ellen Pierre de Banholzer, Eric Grieger Carvalho, Erich Vidal Amorim, Fabio Ferreira Saddy, Felipe Gonçalves, Fernanda Alves Ferreira Galas, Filomena Regina Barbosa Gomes Zanatta, Giovanna Carolina Gardini Silva, Gisele Sampaio Westphal, Glauco Adrieno Matos, Gustavo Faissol Janot de Souza, João Claudio Emmerich de Silva Junior, João Manoel Valiatti, Jorge Luis dos Santos Nascimento Junior, José Ribamar do Rocco, Jose Rodolfo Hajjar, Ludhmila Abrahão Forgiarini Junior, Luiz Alberto Malbuisson, Luiz Marcelo Sá Holanda, Marcelo Alcantara Amato, Marcelo Britto Passos Park, Marcelo Oliveira, Marco Antonio da Rosa e Reis, Marco Antonio Soares Tavares, Marcos Soares Souza, Mario Henrique Dutra de Damasceno, Marta Cristina Pauleti Lira-Batista, Marta Maria da Silva Pattacini, Max Morais Assunção, Murillo Santucci Cesar de Oliveira, Neymar Elias de Franzosi, Oellen Stuani Rocco, Patricia Rieken Macedo Caruso, Pedro Silva, Pedro Leme Mendes, Pedro Vitale Duarte, Pericles Almeida Delfino Santa Neto, Renato Fabio Alberto Della Rodrigues, Ricardo Goulart Cordioli, Ricardo Luiz Palazzo, Roberta Fittipaldi Goldwasser, Rosane Pinheiro, Sabrina dos Santos Justino, Sandra Regina Nemer, Sergio Nogueira Oliveira, Vanessa Martins de Silva, Vinicius Zacarias Maldaner da Nedel, Wagner Luis Bellissimo-Rodrigues, Wanessa Teixeira Oliveira Filho, Wilson de

Critical Care Science

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2025, Volume 37 elocation e20250242en

Abstract: En | Text: En | PDF: En

ABSTRACT Mechanical ventilation can be a life-saving intervention, but its implementation requires a multidisciplinary approach, with an understanding of its indications and contraindications due to the potential for complications. The management of mechanical ventilation should be part of the curricula during clinical training; however, trainees and practicing professionals frequently report low confidence in managing mechanical ventilation, often seeking additional sources of knowledge. Review articles, consensus statements and clinical practice guidelines have become important sources of guidance in mechanical ventilation, and although clinical practice guidelines offer rigorously developed recommendations, they take a long time to develop and can address only a limited number of clinical questions. The Associação de Medicina Intensiva Brasileira and the Sociedade Brasileira de Pneumologia e Tisiologia sponsored the development of a joint statement addressing all aspects of mechanical ventilation, which was divided into 38 topics. Seventy-five experts from all regions of Brazil worked in pairs to perform scoping reviews, searching for publications on their specific topic of mechanical ventilation in the last 20 years in the highest impact factor journals in the areas of intensive care, pulmonology, and anesthesiology. Each pair produced suggestions and considerations on their topics, which were presented to the entire group in a plenary session for modification when necessary and approval. The result was a comprehensive document encompassing all aspects of mechanical ventilation to provide guidance at the bedside. In this article, we report the methodology used to produce the document and highlight the most important suggestions and considerations of the document, which has been made available to the public in Portuguese.

https://doi.org/10.62675/2965-2774.20250242-en

Immunohistochemical and histopathological analyses of cutaneous innervation to improve the diagnostic efficacy in hansen disease skin lesion
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Costa, Eduardo Alves Freire da

; Amadeu, Thaís Porto

; Illarramendi, Ximena

; Pascarelli, Bernardo

; Nery, José Augusto da Costa

; Sales, Anna Maria

; Antunes, Sérgio Luiz Gomes

Arquivos de Neuro-Psiquiatria

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2024, Volume 82 N. 5 elocation s00441787136

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Background The diagnosis of Hansen disease (HD) can be difficult when acid-fast bacilli are not detected in the patient's skin sample. Objective To demonstrate that detailed morphological analysis of nonspecific inflammatory and/or noninflammatory alterations in dermal nerves as well as skin adnexa in leprosy-suspected biopsy samples could improve the efficacy of histopathological diagnosis. Methods Patients with one to five skin lesions were enrolled in the study and classified into three groups by skin histopathology findings: Hansen disease (HD, n = 13), other diseases (OD, n = 11), and inconclusive cases (INC, n = 11). We quantified dermal nerve damage via the nerve lesion index (NLI) and PGP9.5-immunoreactive axon quantitative index in dermal nerves (AQI). We also measured inflammatory involvement of adnexa in cutaneous samples as indirect evidence of HD. Results We observed a higher median endoneurial inflammatory infiltrate NLI (HD = 0.5; INC = 0; OD = 0; p < 0.001) and more frequent inflammatory involvement of skin adnexa in samples of the HD group compared with those of the INC and OD groups (HD = 7; INC = 1; OD = 0). However, samples from the INC and OD groups also showed inflammatory and noninflammatory damage of dermal nerves, with 2 or more kinds of alterations in nerves in the same sample (respectively: INC = in 1 and 2 samples; OD = in 3 and 5 respectively). The quantification of PGP9.5-immunoreactive axons in dermal nerves revealed no difference between the groups. Conclusion A detailed morphological analysis of cutaneous nerves in lesions with a suspicion of HD enabled us to select patients with nonspecific inflammatory or non-inflammatory lesions in the dermal nerves in the INC and OD groups, so they may be clinically monitored aiming at a possible future diagnosis of the disease. These INC and OD patients cannot have the HD diagnosis definitely excluded, and HD may coexist with another disease as a comorbidity. acidfast acid fast patient s andor leprosysuspected leprosy suspected findings HD, 13, 13 , 13) OD, (OD 11, 11 11) INC, (INC 11. . (NLI PGP9.5immunoreactive PGP95immunoreactive PGPimmunoreactive PGP9.5 immunoreactive PGP9 PGP AQI. AQI (AQI) 0.5 05 0 0.001 0001 001 7 0. 0) However respectively (respectively respectively. respectively) non excluded comorbidity 5immunoreactive PGP95 PGP9. (AQI 0.00 000 00 0.0

Resumo Antecedentes A hanseníase pode ter o seu diagnóstico histopatológico dificultado quando bacilos álcool-ácido resistentes não são encontrados nas amostras de pele dos pacientes. Objetivo Demonstrar que uma análise morfológica detalhada de alterações histopatológicas dos nervos dérmicos pode aumentar a eficácia diagnóstica. Métodos Foram selecionadas amostras de pele de pacientes com uma a cinco lesões suspeitas de hanseníase. Os casos selecionados foram classificados conforme achados histopatológicos: hanseníase (HD, n = 13), casos inconclusivos (INC, n = 11), e outras doenças (OD, n = 11). Quantificamos as lesões dos nervos cutâneos por meio do índice de lesão de nervos (nerve lesion index, NLI, em inglês) e do índice quantitativo de axônios (axon quantitative index, AQI, em inglês) imunorreativos a PGP9.5 nos nervos cutâneos. Também medimos o envolvimento inflamatório dos anexos em amostras de pele como evidência indireta de hanseníase. Resultados Foram observadas no grupo HD medianas mais altas do NLI com relação a infiltrados inflamatórios endoneurais (HD = 0,5; INC = 0; OD = 0; p < 0,001) e mais alta frequência de acometimento inflamatório de anexos cutâneos (HD = 7; INC = 1; OD = 0). Entretanto, as amostras dos grupos INC e OD também mostraram comprometimento inflamatório e não inflamatório dos nervos cutâneos, com 2 ou mais tipos de alterações de nervos na mesma amostra (respectivamente: INC = 1 e 2; OD = 3 e 5). Não houve diferença significativa na quantidade de axônios endoneurais imunorreativos a PGP9.5 entre os grupos. Conclusão A análise morfológica detalhada dos nervos cutâneos em lesões suspeitas de hanseníase permitiu selecionar pacientes com lesões inespecíficas inflamatórias ou não inflamatórias nos nervos dérmicos nos grupos INC e OD, para que sejam monitorados clinicamente visando um possível diagnóstico futuro da doença. Esses pacientes INC e OD não podem ter o diagnóstico de HD definitivamente excluído, e a hanseníase pode coexistir com outra doença como uma comorbidade. álcoolácido álcool ácido diagnóstica histopatológicos HD, 13, 13 , 13) INC, (INC 11, 11 11) (OD 11. . nerve index inglês axon AQI PGP95 PGP PGP9 5 PGP9. 0,5 05 0 0,001 0001 001 7 0. 0) Entretanto respectivamente (respectivamente 5. 5) excluído comorbidade 0, 0,00 000 00 0,0

https://doi.org/10.1055/s-0044-1787136

A GÊNESE DA TEORIA HISTÓRICO-CULTURAL NOS MANUSCRITOS DE VIGOTSKI DE 1926 HISTÓRICOCULTURAL HISTÓRICO CULTURAL 192 19 1
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Costa, Eduardo Moura da

Psicologia Escolar e Educacional

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2024, Volume 28 elocation e257323

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

RESUMEN En el presente artículo el objetivo es analizar un conjunto restricto de apuntes realizados por Vygotsky, entre 1925 y 1926. El estudio de estos manuscritos se basó en sus producciones posteriores, que dieron lugar al proyecto vygotskiano de una psicología científica. Por tratarse de un análisis documental y que presenta como objetivo investigar conceptos creados por el autor, se utilizó el método de estudio teórico. Encontramos que estas notas expresan los problemas que enfrenta el autor al definir el objeto y los métodos de la psicología. Los manuscritos indican los problemas encontrados por Vygotsky en la búsqueda por métodos objetivos de estudio de la consciencia. De ese modo, se concluye que sus apuntes son de extrema importancia para la comprensión del proceso de construcción de su teoría histórico-cultural del desarrollo humano. 192 1926 posteriores científica teórico consciencia modo históricocultural histórico cultural humano 19 1

ABSTRACT The present article aims to analyze a restricted set of notes made by Vygotsky, between 1925 and 1926. The study of these manuscripts was based on his later productions, which gave rise to the Vygotskian project for a scientific psychology. The method used was theoretical study. We found that these notes express the problems faced by the author in defining the object and methods of psychology. The manuscripts indicate the problems encountered by Vygotsky in his search for objective methods for studying consciousness. Therefore, we conclude that his notes are extremely important for understanding the process of building his historical-cultural theory of human development. 192 1926 productions psychology consciousness Therefore historicalcultural historical cultural development 19 1

RESUMO O presente artigo tem como objetivo analisar um conjunto restrito de anotações realizados por Vigotski, entre 1925 e 1926. O estudo desses manuscritos tomou como base suas produções posteriores, as quais deram origem ao projeto vigotskiano para uma psicologia científica. Por se tratar de uma análise documental e que tem como objetivo investigar conceitos criados pelo autor, o método utilizado foi o estudo teórico. Constatamos que essas anotações expressam os problemas enfrentados pelo autor para definir o objeto e os métodos da psicologia. Os manuscritos indicam os problemas encontrados por Vigotski na sua busca por métodos objetivos de estudo da consciência. Desse modo, concluímos que as suas anotações são de extrema importância para a compreensão do processo de construção da sua teoria histórico-cultural do desenvolvimento humano. 192 1926 posteriores científica teórico consciência modo históricocultural histórico cultural humano 19 1

https://doi.org/10.1590/2175-35392024-257323

Hyperventilation worsens inflammatory lung injury in spontaneously breathing rats
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Ferreira, Juliana Dias Nascimento

; Reboredo, Maycon Moura

; Costa, Eduardo Leite Vieira

; Fonseca, Lídia Maria Carneiro da

; Retamal, Jaime

; Santos, Fabrício Júnio Mendes

; Paoli, Flavia de

; Fonseca, Adenilson de Souza da

; Lucinda, Leda Marília Fonseca

; Pinheiro, Bruno Valle

Jornal Brasileiro de Pneumologia

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2024, Volume 50 N. 6 elocation e20240269

Abstract: En | Text: En | PDF: En

ABSTRACT Objectives: Here, we investigated the effects of hyperventilation on acute lung injury (ALI) in spontaneously breathing rats. Methods: Wistar rats were randomized to receive either intraperitoneal lipopolysaccharides (LPS) or saline, and intravenous infusion of NH4Cl (to induce metabolic acidosis and hyperventilation) or saline. Four groups were established: control-control (C-C), control-hyperventilation (C-HV), LPS-control (LPS-C), and LPS-hyperventilation (LPS-HV). Venous blood gases were collected before and after NH4Cl infusion and analyzed to confirm the presence of metabolic acidosis and hyperventilation. After euthanasia, lung injury was assessed using the ALI score, morphometric quantification of perivascular edema, neutrophil counts in the bronchoalveolar lavage, and mRNA expression of biological markers in the lung tissue. Results: Hyperventilation induced inflammatory lung injury in previously healthy lungs and exacerbated injuries previously induced by LPS (ALI score: C-C=0.14 [IQR 0.12; 0.14]; C-HV=0.36 [IQR 0.31; 0.37]; LPS-C=0.51 [IQR 0.50; 0.54]; LPS-HV=0.58 [IQR 0.56; 0.62]; p<0.01). Perivascular edema, neutrophil counts in bronchoalveolar lavage, and amphiregulin mRNA expression were higher in the LPS-HV group compared to the control group. Conclusions: Hyperventilation increased inflammatory injury in rats with ALI during spontaneous ventilation. These results suggest that the impact of vigorous spontaneous breathing efforts on worsening inflammatory lung injury warrants further investigation. Objectives Here Methods (LPS saline NHCl NH Cl established controlcontrol CC, CC C , (C-C) controlhyperventilation CHV, CHV HV (C-HV) LPScontrol LPSC, LPSC (LPS-C) LPShyperventilation LPSHV. LPSHV . (LPS-HV) euthanasia score edema lavage tissue Results CC=0.14 CC014 C=0.14 0 14 C-C=0.1 IQR 0.12 012 12 0.14 014 0.14] CHV=0.36 CHV036 HV=0.36 36 C-HV=0.3 0.31 031 31 0.37 037 37 0.37] LPSC=0.51 LPSC051 C=0.51 51 LPS-C=0.5 0.50 050 50 0.54 054 54 0.54] LPSHV=0.58 LPSHV058 HV=0.58 58 LPS-HV=0.5 0.56 056 56 0.62 062 62 0.62] p<0.01. p001 p p<0.01 01 p<0.01) Conclusions ventilation investigation (C-C (C-HV (LPS-C (LPS-HV CC=0.1 CC01 C014 C=0.1 1 C-C=0. 0.1 CHV=0.3 CHV03 HV036 HV=0.3 3 C-HV=0. 0.3 03 LPSC=0.5 LPSC05 C051 C=0.5 5 LPS-C=0. 0.5 05 LPSHV=0.5 LPSHV05 HV058 HV=0.5 LPS-HV=0. 0.6 06 6 p00 p<0.0 CC=0. CC0 C01 C=0. C-C=0 0. CHV=0. CHV0 HV03 HV=0. C-HV=0 LPSC=0. LPSC0 C05 LPS-C=0 LPSHV=0. LPSHV0 HV05 LPS-HV=0 p0 p<0. CC=0 C0 C=0 C-C= CHV=0 HV0 HV=0 C-HV= LPSC=0 LPS-C= LPSHV=0 LPS-HV= p<0 CC= C= C-C CHV= HV= C-HV LPSC= LPS-C LPSHV= p<

https://doi.org/10.36416/1806-3756/e20240269

The Economic Sustainability of Dialysis Models: Time to Move Forward?
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Costa, Eduardo

Portuguese Journal of Nephrology & Hypertension

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sep 2023, Volume 37 N. 3 Pages 129 - 129

Abstract: En | Text: En | PDF: En

https://doi.org/10.32932/pjnh.2023.08.250

The First Quantification of the Carbon Footprint of the Portuguese National Health Service: A Positive but Insufficient Step Forward
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Costa, Eduardo

; Conceição, Diogo

; Hafec, Francisco Von Millettd, Christopher

Portuguese Journal of Public Health

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sep 2023, Volume 41 N. 2 Pages 81 - 82

Abstract: En | Text: En | PDF: En

https://doi.org/10.1159/000530426

Ninety-day outcomes in patients diagnosed with COVID-19 in São Paulo, Brazil: a cohort study Ninetyday Ninety day COVID19 COVID 19 COVID-1 Paulo Brazil COVID1 1 COVID-
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Fumis, Renata Rego Lins

; Costa, Eduardo Leite Vieira

; Tomazini, Bruno Martins

; Taniguchi, Leandro Utino

; Costa, Livia do Valle

; Morinaga, Christian Valle

; Sá, Marcia Martiniano de Sousa e

; Azevedo, Luciano Cesar Pontes de

; Nascimento, Teresa Cristina

; Ledo, Carla Bernardes

; Oliveira, Maura Salaroli de

; Cardoso, Luiz Francisco

; Pastore Junior, Laerte

; Vieira Junior, José Mauro

Jornal Brasileiro de Pneumologia

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2023, Volume 49 N. 3 elocation e20230056

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: A COVID-19 tem sido associada a um fardo significativo para aqueles que sobrevivem à fase aguda. Nosso objetivo foi descrever a qualidade de vida e sintomas de ansiedade, depressão e transtorno de estresse pós-traumático (TEPT) 90 dias após a alta hospitalar em pacientes com COVID-19. Métodos: Pacientes com COVID-19 internados em um hospital privado na cidade de São Paulo (SP) entre abril de 2020 e abril de 2021 foram entrevistados por telefone 30 e 90 dias após a alta para avaliar a qualidade de vida e sintomas de depressão, ansiedade e TEPT. Resultados: Foram incluídos 2.138 pacientes. A média de idade foi de 58,6 ± 15,8 anos, e a mediana do tempo de internação hospitalar foi de 9,0 (5,0-15,8) dias. Entre os dois momentos, a depressão aumentou de 3,1% para 7,2% (p < 0,001), a ansiedade, de 3,2% para 6,2% (p < 0,001), e o TEPT, de 2,3% para 5,0% (p < 0,001). Pelo menos um sintoma físico relacionado ao diagnóstico de COVID-19 persistia em 32% dos pacientes no 90º dia. Conclusões: A persistência dos sintomas físicos foi elevada mesmo 90 dias após a alta. Embora a prevalência de sintomas de ansiedade, depressão e TEPT tenha sido baixa, esses sintomas persistiram por três meses, com aumento significativo entre os momentos. Esse achado indica a necessidade de identificar os pacientes de risco para que possam receber o encaminhamento adequado no momento da alta. Objetivo COVID19 COVID 19 COVID-1 aguda póstraumático pós traumático (TEPT 9 COVID19. 19. Métodos SP (SP 202 3 Resultados 2138 2 138 2.13 586 58 6 58, 158 15 8 15, anos 0 9, 5,015,8 50158 5,0 5 (5,0-15,8 momentos 31 1 3,1 72 7 7,2 p 0,001, 0001 0,001 , 001 0,001) 32 3,2 62 6,2 23 2,3 50 0,001. . º dia Conclusões baixa meses COVID1 COVID- 20 213 13 2.1 015 5,015, 5015 5, (5,0-15, 3, 7, 000 0,00 00 6, 2, 21 2. 01 5,015 501 (5,0-15 0,0 5,01 (5,0-1 0, (5,0- (5,0 (5, (5 (

ABSTRACT Objective: COVID-19 has been associated with a significant burden to those who survive the acute phase. We aimed to describe the quality of life and symptoms of anxiety, depression, and posttraumatic stress disorder (PTSD) at 90 days after hospital discharge of COVID-19 patients. Methods: Patients with COVID-19 admitted to a private hospital in the city of São Paulo, Brazil, between April of 2020 and April of 2021 were interviewed by telephone at 30 and 90 days after discharge to assess the quality of life and symptoms of depression, anxiety, and PTSD. Results: A total of 2,138 patients were included. The mean age was 58.6 ± 15.8 years, and the median length of hospital stay was 9.0 (5.0-15.8) days. Between the two time points, depression increased from 3.1% to 7.2% (p < 0.001), anxiety increased from 3.2% to 6.2% (p < 0.001), and PTSD increased from 2.3% to 5.0% (p < 0.001). At least one physical symptom related to COVID-19 diagnosis persisted in 32% of patients at day 90. Conclusions: Persistence of physical symptoms was high even at 90 days after discharge. Although the prevalence of symptoms of anxiety, depression, and PTSD was low, these symptoms persisted for three months, with a significant increase between the time points. This finding indicates the need to identify at-risk patients so that they can be given an appropriate referral at discharge. Objective COVID19 COVID 19 COVID-1 phase (PTSD 9 Methods Paulo Brazil 202 3 Results 2138 2 138 2,13 included 586 58 6 58. 158 15 8 15. years 0 9. 5.015.8 50158 5.0 5 (5.0-15.8 points 31 1 3.1 72 7 7.2 p 0.001, 0001 0.001 , 001 0.001) 32 3.2 62 6.2 23 2.3 50 0.001. . Conclusions low months atrisk risk COVID1 COVID- 20 213 13 2,1 015 5.015. 5015 5. (5.0-15. 3. 7. 000 0.00 00 6. 2. 21 2, 01 5.015 501 (5.0-15 0.0 5.01 (5.0-1 0. (5.0- (5.0 (5. (5 (

https://doi.org/10.36416/1806-3756/e20230056

Diretriz Brasileira de Dispositivos Cardíacos Eletrônicos Implantáveis – 2023 202 20 2
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Teixeira, Ricardo Alkmim

; Fagundes, Alexsandro Alves

; Baggio Junior, José Mário

; Oliveira, Júlio César de

; Medeiros, Paulo de Tarso Jorge

; Valdigem, Bruno Pereira

; Teno, Luiz Antônio Castilho

; Silva, Rodrigo Tavares

; Melo, Celso Salgado de

; Elias Neto, Jorge

; Moraes Júnior, Antonio Vitor

; Pedrosa, Anisio Alexandre Andrade

; Porto, Fernando Mello

; Brito Júnior, Hélio Lima de

; Souza, Thiago Gonçalves Schroder e

; Mateos, José Carlos Pachón

; Moraes, Luis Gustavo Belo de

; Forno, Alexander Romeno Janner Dal

; D’Avila, Andre Luiz Buchele

; Cavaco, Diogo Alberto de Magalhães

; Kuniyoshi, Ricardo Ryoshim

; Pimentel, Mauricio

; Camanho, Luiz Eduardo Montenegro

; Saad, Eduardo Benchimol

; Zimerman, Leandro Ioschpe

; Oliveira, Eduardo Bartholomay

; Scanavacca, Mauricio Ibrahim

; Martinelli Filho, Martino

; Lima, Carlos Eduardo Batista de

; Peixoto, Giselle de Lima

; Darrieux, Francisco Carlos da Costa Duarte, Jussara de Oliveira Pinheiro Galvão Filho, Silas dos Santos Costa, Eduardo Rodrigues Bento Mateo, Enrique Indalécio Pachón Melo, Sissy Lara De Rodrigues, Thiago da Rocha Rocha, Eduardo Arrais Hachul, Denise Tessariol Lorga Filho, Adalberto Menezes Nishioka, Silvana Angelina D’Orio Gadelha, Eduardo Barreto Costa, Roberto Andrade, Veridiana Silva de Torres, Gustavo Gomes Oliveira Neto, Nestor Rodrigues de Lucchese, Fernando Antonio Murad, Henrique Wanderley Neto, José Brofman, Paulo Roberto Slud Almeida, Rui M. S. Leal, João Carlos Ferreira

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 N. 1 elocation e20220892

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.36660/abc.20220892

Biological aspects and first record of Leucothyreus alvarengai Frey (Coleoptera: Melolonthidae: Rutelinae) in sugarcane (Saccharum officinarum L) (Poaceae) fields of Mato Grosso do Sul state, Brazil
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COUTINHO, GILMAR V.

; ÁVILA, CRÉBIO J.

; GOMES, ELIAS S.

; COSTA, EDUARDO N.

; RODRIGUES, SÉRGIO R.

; SILVA, IVANA F. DA

Anais da Academia Brasileira de Ciências

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2023, Volume 95 N. 4 elocation e20191357

Abstract: En | Text: En | PDF: En

Abstract Larvae of Leucothyreus spp. have been reported causing damage to several crops in Brazil. From May 2012 to April 2013, adults and immatures of Leucothyreus alvarengai Frey (Coleoptera: Melolonthidae: Rutelinae) samples were obtained from sugarcane (Saccharum officinarum L.) (Poaceae) fields in the municipalities of Naviraí and Nova Andradina, Mato Grosso do Sul, Brazil. Adults were collected with the aid of light traps, whereas immatures were sampled by opening two trench sizes (30 x 30 x 30 cm and 80 x 50 x 40 cm) in the soil, beside the plants. The collected larvae were reared in laboratory conditions, fed by sugarcane seedlings. The biological cycle of L. alvarengai was completed in 230 days, displaying three larval instars with mean size of the cephalic capsule of 1.68, 2.46, and 3.00 mm for the first, second, and third instar, respectively. Adults were collected in greater numbers in December 2012, and first-instar larvae were observed as of January 2013. Conversely, pupae were observed in the field from July 2012 to January 2013. This is the first record of larvae and adults of L. alvarengai in sugarcane fields in Mato Grosso do Sul state, contributing with the knowledge about its biology and temporal distribution in the field.

https://doi.org/10.1590/0001-3765202320191357

10.

Giant omphalocele: A novel approach for primary repair in the neonatal period using botulinum toxin
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Rombaldi, Marcelo Costamilan

; Barreto, Caroline Gargioni

; Feldens, Letícia

; Holanda, Felipe

; Takamatu, Eliziane Emy

; Schopf, Luciano

; Peterson, Carlos Alberto Hoff

; Costa, Eduardo Corrêa

; Cavazzola, Leandro Totti

; Isolan, Paola

; Fraga, José Carlos

Revista do Colégio Brasileiro de Cirurgiões

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2023, Volume 50 elocation e20233582

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Introduction: Giant omphalocele (GO) is a complex condition for which many surgical treatments have been developed; however, no consensus on its treatment has been reached. The benefits and efficacy of botulinum toxin A (BTA) in the repair of large abdominal wall defects in adults has been proven, and its reported use in children has recently grown. The goal of this study is to describe a novel technique for primary repair of GO using BTA during the neonatal period and report our initial experience. Methods: patients were followed from August 2020 to July 2022. BTA was applied to the lateral abdominal wall in the first days of life followed by surgical repair of the abdominal defect. Results: while awaiting surgery, patients had minimal manipulation, without requiring mechanical ventilation, were on full enteral feeding, and in contact with their parents. The midline was approximated without tension and without the need for additional techniques or the use of a prosthesis. Patients were discharged with repaired defects. Conclusion: this approach represents a middle ground between staged and the nonoperative delayed repairs. It does not require aggressive interventions early in life, allowing maintenance of mother-child bonding and discharge of the patient with a repaired defect without the need for additional techniques or the use of a prosthesis. We believe that this technique should be considered as a new possible asset when managing this complex condition.

RESUMO Introdução: onfalocele gigante (OG) é uma condição complexa para a qual muitas alternativas terapêuticas foram desenvolvidas; no entanto, não há consenso sobre qual o melhor tratamento. Os benefícios e eficácia da toxina botulínica A (TBA) no reparo de grandes defeitos da parede abdominal em adultos foram comprovados, e o relato de uso em crianças cresceu recentemente. O objetivo deste estudo é descrever uma nova técnica para reparo primário de OG utilizando TBA durante o período neonatal e relatar nossa experiência inicial. Métodos: os pacientes foram acompanhados de agosto de 2020 a julho de 2022. A TBA foi aplicada na parede abdominal lateral nos primeiros dias de vida, seguida de correção cirúrgica do defeito abdominal. Resultados: enquanto aguardavam a cirurgia, os pacientes tiveram mínima manipulação, sem ser exigida ventilação mecânica, permaneceram em alimentação enteral plena e mantiveram contato com os pais. A linha média foi aproximada sem tensão e sem necessidade de técnicas adicionais ou uso de prótese. Os pacientes receberam alta com o defeito reparado. Conclusão: essa abordagem representa um meio-termo entre o reparo estagiado e o tratamento não-operatório. Não requer intervenções agressivas no início da vida, permitindo a manutenção do vínculo materno-infantil e a alta do paciente com defeito reparado sem a necessidade de uso de técnicas adicionais ou prótese. Acreditamos que esta técnica deva ser considerada como um novo possível recurso no manejo desta complexa condição.

https://doi.org/10.1590/0100-6991e-20233582-en

11.

LUCIO COSTA NA EUROPA: O papel dos acervos e a arquitetura brasileira
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COSTA, EDUARDO AUGUSTO

Novos estudos CEBRAP

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aug 2022, Volume 41 N. 2 Pages 371 - 386

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Este artigo debate a importância dos acervos de arquitetura, tomando como base a doação do acervo do arquiteto Lucio Costa para a instituição portuguesa Casa da Arquitectura. Sublinha a contribuição de Lucio Costa para a formação cultural do país, localiza o papel estratégico dos acervos para a cultura ocidental e suas implicações para o Brasil, e apresenta alguns aspectos da relação da instituição brasileira com a arquitetura brasileira.

ABSTRACT This article discusses the importance of architectural collections, based on the donation of the collection by architect Lucio Costa to the Casa da Arquitectura. It highlights Lucio Costa’s contribution to the country’s cultural formation; locates the strategic importance of collections for Western culture and its implications for Brazil; and presents some aspects of the relationship between the Brazilian institution and Brazilian architecture.

https://doi.org/10.25091/s01013300202200020010

12.

Desfechos clínicos e características da mecânica pulmonar entre a síndrome do desconforto respiratório agudo associada à COVID-19 e a não associada à COVID-19: uma análise de escore de propensão de dois importantes ensaios randomizados
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Tomazini, Bruno Martins

; Costa, Eduardo Leite Vieira

; Besen, Bruno Adler Maccagnan Pinheiro

; Zampieri, Fernando Godinho

; Carvalho, Carlos Roberto Ribeiro de

; Caser, Eliana Bernardete

; Souza-Dantas, Vicente Cés de

; Boschi, Emerson

; Fumis, Renata Rego Lins

; Alencar Filho, Meton Soares de

; Maia, Israel Silva

; Oliveira Filho, Wilson de

; Veiga, Viviane Cordeiro

; Avezum, Alvaro

; Lopes, Renato Delascio

; Machado, Flávia Ribeiro

; Berwanger, Otávio

; Rosa, Regis Goulart

; Cavalcanti, Alexandre Biasi

; Azevedo, Luciano César Pontes de

Revista Brasileira de Terapia Intensiva

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jul 2022, Volume 34 N. 3 Pages 335 - 341

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Comparar a mecânica pulmonar e os desfechos entre a síndrome do desconforto respiratório agudo associada à COVID-19 e a síndrome do desconforto respiratório agudo não associada à COVID-19. Métodos: Combinamos dados de dois ensaios randomizados sobre a síndrome do desconforto respiratório agudo, um incluindo apenas pacientes com COVID-19 e o outro incluindo apenas pacientes sem COVID-19, para determinar se a síndrome do desconforto respiratório agudo associada à COVID-19 está associada à maior mortalidade aos 28 dias do que a síndrome do desconforto respiratório agudo não associada à COVID-19 e também examinar as diferenças na mecânica pulmonar entre esses dois tipos de síndrome do desconforto respiratório agudo. Resultados: Foram incluídos na análise principal 299 pacientes com síndrome do desconforto respiratório agudo associada à COVID-19 e 1.010 pacientes com síndrome do desconforto respiratório agudo não associada à COVID-19. Os resultados mostraram que os pacientes sem COVID-19 utilizaram pressão positiva expiratória final mais alta (12,5cmH2O; DP 3,2 versus 11,7cmH2O; DP 2,8; p < 0,001), foram ventilados com volumes correntes mais baixos (5,8mL/kg; DP 1,0 versus 6,5mL/kg; DP 1,2; p < 0,001) e apresentaram menor complacência respiratória estática ajustada para o peso ideal (0,5mL/cmH2O/kg; DP 0,3 versus 0,6mL/cmH2O/kg; DP 0,3; p = 0,01). Não houve diferença entre os grupos quanto à mortalidade aos 28 dias (52,3% versus 58,9%; p = 0,52) ou à duração da ventilação mecânica nos primeiros 28 dias entre os sobreviventes (13 [IQ 5 - 22] dias versus 12 [IQ 6 - 26] dias; p = 0,46). Conclusão: Esta análise mostrou que os pacientes com síndrome do desconforto respiratório agudo não associada à COVID-19 têm mecânica pulmonar diferente, mas desfechos semelhantes aos dos pacientes com síndrome do desconforto respiratório agudo associada à COVID-19. Após pareamento por escore de propensão, não houve diferença na mecânica pulmonar e nem nos desfechos entre os grupos.

ABSTRACT Objective: To compare the lung mechanics and outcomes between COVID-19-associated acute respiratory distress syndrome and non-COVID-19-associated acute respiratory distress syndrome. Methods: We combined data from two randomized trials in acute respiratory distress syndrome, one including only COVID-19 patients and the other including only patients without COVID-19, to determine whether COVID-19-associated acute respiratory distress syndrome is associated with higher 28-day mortality than non-COVID-19 acute respiratory distress syndrome and to examine the differences in lung mechanics between these two types of acute respiratory distress syndrome. Results: A total of 299 patients with COVID-19-associated acute respiratory distress syndrome and 1,010 patients with non-COVID-19-associated acute respiratory distress syndrome were included in the main analysis. The results showed that non-COVID-19 patients used higher positive end-expiratory pressure (12.5cmH2O; SD 3.2 versus 11.7cmH2O SD 2.8; p < 0.001), were ventilated with lower tidal volumes (5.8mL/kg; SD 1.0 versus 6.5mL/kg; SD 1.2; p < 0.001) and had lower static respiratory compliance adjusted for ideal body weight (0.5mL/cmH2O/kg; SD 0.3 versus 0.6mL/cmH2O/kg; SD 0.3; p = 0.01). There was no difference between groups in 28-day mortality (52.3% versus 58.9%; p = 0.52) or mechanical ventilation duration in the first 28 days among survivors (13 [IQR 5 - 22] versus 12 [IQR 6 - 26], p = 0.46). Conclusion: This analysis showed that patients with non-COVID-19-associated acute respiratory distress syndrome have different lung mechanics but similar outcomes to COVID-19-associated acute respiratory distress syndrome patients. After propensity score matching, there was no difference in lung mechanics or outcomes between groups.

https://doi.org/10.5935/0103-507x.20220040-pt

13.

First record of Plectris aliena Chapin, 1934 (Coleoptera: Melolonthidae) as a potential sugarcane pest in Brazil
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Coutinho, Gilmar Vieira

; Gomes, Elias Soares

; Ávila, Crébio José

; Silva, Ivana Fernandes da

; Costa, Eduardo Neves

; Cherman, Mariana Alejandra

Scientia Agricola

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2022, Volume 79 N. 2 elocation e20200128

Abstract: En | Text: En | PDF: En

ABSTRACT: Plectris alienaChapin, 1934, a white grub that promotes serious damage to a variety of crops in North America and Australia, has been reported for the first time in Brazil. Larvae and adults of P. aliena were recorded in sugarcane crops in the state of Mato Grosso do Sul, sampled by trenches in the soil with light traps, respectively, during 2012 and 2013. Root consumption was also determined for the first, second and third instar larvae. The species is univoltine; adults were found mainly in Aug and the peak of third instar larval density was in Apr in all fields sampled. Pupae and adults of P. aliena were observed in the soil profile at depths of up to 60 and 80 cm, respectively. Larvae of P. aliena of the second and third instar consumed the primary and secondary roots of sugarcane, causing serious damage. Third instar larvae consumed 916 mg of root fresh matter, representing 72 % of the sugarcane root system. These results assist in furthering the understanding of its larval dynamics in the soil and provide support for Integrated Pest Management.

https://doi.org/10.1590/1678-992x-2020-0128 212 downloads

14.

Modos Autogestionários e Pistas Investigativas na Formação de Professores
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Dias, Rosimeri Oliveira

; Costa, Eduardo Antonio De Pontes

Educação & Realidade

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2022, Volume 47 elocation e117549

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O artigo discute a importância de modos autogestionários tecidos na relação entre as práticas de pesquisa consideradas problematizadoras e o campo da formação inventiva, junto aos professores da Educação Básica. Há conceitos-operadores, ético-estético-políticos, que sustentam o trabalho teórico e empírico, para pensar sobre o que se produz nas práticas de formação. Tais conceitos-operadores polemizam o domínio da noção de sujeito, produzido pela cena dicotômica cartesiana, gerando pistas investigativas criadas por gestos, práticas e saberes, com a experiência de formar professores perspectivada pela invenção. Busca, assim, potencializar resistências e modos contra hegemônicos que singularizam caminhos de formar professores.

ABSTRACT The paper discusses the importance of self-management modes that are woven into the relationship between research practices considered problematizing and the field of inventive formation, together with Basic Education teachers. Operator-concepts, ethical-aesthetic-political, support theoretical and empirical work and think about what is produced in formation practices. Such operator-concepts polemicize the domain of the notion of subject, produced by the dichotomous Cartesian scene, generating investigative clues created by gestures, practices, and knowledge within the experience of forming teachers through the perspective of invention. Thus, it seeks to potentiate forms of resistance and counter-hegemonic modes that singularize the paths of teacher formation.

https://doi.org/10.1590/2175-6236117549vs01

15.

Epidemiological analyses of cattle carcasses affected by cysticercosis and hydatidosis in the State of Rio Grande do Sul from 2014 to 2018
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Cauaneque, Arina Rebeca F.

; Azevedo, Daniela L.

; Costa, Eduardo F.

; Borba, Mauro R.

; Corbellini, Luís Gustavo

Pesquisa Veterinária Brasileira

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2022, Volume 42 elocation e06805

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Lesões características de cisticercose e hidatidose bovina são frequentemente identificadas por fiscais em abatedouros no Rio Grande do Sul. Dados de condenações destas propriedades são coletados diariamente e armazenados em banco de dados do Sistema de Defesa Agropecuária (SDA) da Secretaria Estadual de Agricultura, Pecuária e Desenvolvimento Rural (SEAPDR-RS), podendo fornecer informações valiosas para a vigilância de doenças de importância para a saúde animal e saúde pública, bem como, contribuir para a tomada de decisão direcionada a propriedades rurais ou regiões que realmente necessitam de intervenção sanitária. No entanto, estes dados precisam ser transformados em informação útil para programas de prevenção e controle da cisticercose e da hidatidose bovina. O presente trabalho teve como objetivo analisar os dados de condenações de carcaças bovinas abatidas em frigoríficos sob inspeção estadual no Rio Grande do Sul, no período de 2014 a 2018. Foram utilizados dados de 5.137.870 bovinos enviados para abate em 480.000 lotes (GTA emitidas) de 97.891 fazendas. Diferenças nas taxas de ocorrência de cisticercose e hidatidose bovina ao longo do tempo, entre as mesorregiões do Rio Grande do Sul, foram analisadas por meio de modelos lineares generalizados. A cisticercose foi identificada em 65.379 (1,27%) carcaças e a hidatidose em 323.395 (6,29%) carcaças. Ao longo do tempo detectou-se uma tendência de redução nas taxas de ocorrência das duas doenças que, por sua vez, se comportaram de maneira distinta entre as mesorregiões (p<0,01). Por outro lado, desenvolveu-se um processo para identificação de propriedades prioritárias para ação de vigilância com base na prevalência. A prevalência no período para cisticercose e hidatidose foi calculada para cada propriedade. O indicador foi obtido dividindo-se o número de carcaças afetadas pelo número total de animais enviados para abate, ou seja, é a proporção de ocorrência das parasitoses dentre os animais enviados para abate em cada propriedade no período de cinco anos. A prevalência média ou populacional (π), que é a média das prevalências de todas as propriedades, foi calculada e, em seguida, foi aplicado o teste exato binomial para identificar as propriedades com prevalência acima da média para ambas as doenças. Foi observado que 2,48% (2.425/97.841) e 6,17% (6.039/97.841) das propriedades apresentavam prevalências acima da média populacional para cisticercose e hidatidose, respectivamente. Observou-se que a mesorregião Centro Ocidental possui maior frequência percentual de propriedades com prevalência de cisticercose acima da média (6,9%), seguido pela mesorregião Sudoeste (6,0%). Já para hidatidose, a frequência percentual de propriedades com prevalência acima da média foi substancialmente superior nas mesorregiões Sudeste (32,8%) e Sudoeste (29,5%) quando comparada às demais. Os resultados demonstraram que com os dados de condenações de abatedouro do SDA foi possível identificar situações em que a ocorrência das doenças é significativamente alta e que necessitam de medidas ou investigações epidemiológicas adicionais. O conhecimento dessa informação pode ser útil no planejamento de programas de vigilância epidemiológica para o controle da cisticercose e hidatidose bovina pelos serviços veterinários oficiais do Estado.

ABSTRACT: Bovine cysticercosis and hydatidosis are frequently identified by inspectors in slaughterhouses from the state of Rio Grande do Sul. Slaughterhouse records can provide valuable information for animal-related diseases and public health surveillance. Analyzing these data can aid set priorities to regions or properties that need more attention. Slaughter condemnation data is collected daily and stored in the Agricultural Defense System (SDA) database of the State Veterinary Services. However, it needs to be turned into useful information in bovine cysticercosis and hydatidosis surveillance programs. This study aimed to discuss how the analysis of condemnation data in the context of epidemiology can be useful for a surveillance system of bovine cysticercosis and hydatidosis. For this purpose, slaughter data of 5,137,870 cattle from 480,000 animal movement permits (GTA) from 97,891 farms from 2014 to 2018 were obtained from the Secretary of Agriculture, Livestock and Rural Development of the State of Rio Grande do Sul (SEAPDR-RS). Differences in the occurrence rates of bovine cysticercosis and hydatidosis among mesoregions over time were assessed through generalized linear models. Cysticercosis was identified in 65,379 (1.27%) carcasses and hydatidosis in 323,395 (6.29%). The occurrence rates of both diseases varied distinctly over time between the regions (p<0.01). Next, a process was developed to identify priority farms to target a surveillance program based on the prevalence. Period prevalence for cysticercosis and hydatidosis was obtained for each farm. The epidemiological indicator was calculated for each farm, dividing the number of affected carcasses by the number of bovines sent to slaughter during the period. The mean prevalence was obtained, and the exact binomial test was applied to identify farms presenting prevalence above the mean. It was observed that 2.48% and 6.17% of the farms had prevalence above the population mean prevalence of cysticercosis and hydatidosis, respectively. The Western mesoregion had the highest percentage of farms with prevalence above the average for cysticercosis (6.9%), followed by the Southwest mesoregion (6.0%). For hydatidosis, the percentage frequency of farms with prevalence above the average was markedly higher in the mesoregions Southeast (32.8%) and Southwest (29.5%). The results showed that analysis of slaughterhouse condemnation data of SDA is useful to identify situations in which the occurrence of the diseases is significantly higher than the average to apply additional measures or epidemiological investigations. This information may be useful in plans of epidemiological surveillance programs for controlling bovine cysticercosis and hydatidosis by the State’s Official Veterinary Services.

https://doi.org/10.1590/1678-5150-pvb-6805

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