Resumen Introducción: La modulación de la fatiga post-entrenamiento en colegios y universidades es una parte importante de la educación física universitaria actual. El ajuste de la fatiga deportiva es un aspecto fundamental de la educación física universitaria moderna y su control es de gran importancia para la elevación del nivel deportivo de los atletas. Objetivo: Explorar los efectos de la intervención nutricional sobre la fatiga post-entrenamiento en atletas universitarios. Métodos: 40 atletas fueron seleccionados al azar como voluntarios para la investigación, divididos en grupo control y experimental, practicaron el mismo tipo de ejercicio físico y con la misma intensidad. Los atletas del grupo experimental tomaron alimentos siguiendo estrictamente la mezcla de alimentos descrita en el artículo, mientras que el grupo de control mantuvo su dieta habitual sin cambios. Tras el experimento, se llevó a cabo una sesión de entrenamiento deportivo, seguida de la medición de la enzima creatina muscular y el análisis de laboratorio de la urea en sangre. Estos datos se compararon y analizaron con los anteriores al experimento. Resultados: Tras ajustar la estructura dietética, los índices de CK y Bu de los atletas del grupo experimental mostraron una tendencia descendente, lo que indica que el ajuste de la estructura nutricional puede mejorar eficazmente la fatiga post-entrenamiento de los atletas universitarios. Conclusión: Se recomienda que los profesores de educación física y los entrenadores universitarios ajusten el estilo de vida y la estructura nutricional de acuerdo con la situación real de los estudiantes, con el objetivo de promover el desarrollo integral y la mejora del rendimiento deportivo. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.

ABSTRACT Introduction: The modulation of post-training fatigue in colleges and universities is an important part of today's physical education. The adjustment of sports fatigue is a fundamental aspect of modern college physical education, and its control is of great importance for the elevation in the sport level of athletes. Objective: Explore the effects of nutritional intervention on post-training fatigue in college athletes. Methods: 40 athletes were randomly selected as volunteers for the research, divided into control and experimental group, and practiced the same type of exercise and same intensity. The athletes in the experimental group took food in strict accordance with the food mixture described in the article, while the control group kept their regular diet unchanged. After the experiment, sports training was performed, followed by muscle creatine enzyme measurement and laboratory analysis of blood urea. These data were compared and analyzed with those before the experiment. Results: After adjusting the dietary structure, the CK and Bu indices of the athletes in the experimental group showed a downward trend, indicating that adjusting the nutritional structure can effectively improve the post-training fatigue of college athletes. Conclusion: It is recommended that physical education teachers and college coaches adjust the lifestyle and dietary structure according to the actual situation of the students, aiming to promote integral development and improved sports performance. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.

RESUMO Introdução: A modulação da fadiga pós-treino nas faculdades e universidades é uma parte importante da atual educação física universitária. O ajuste da fadiga esportiva é um aspecto fundamental da educação física universitária moderna e seu controle é de grande importância para a elevação no nível esportivo dos atletas. Objetivo: Explorar os efeitos da intervenção nutricional sobre a fadiga pós-treino dos atletas universitários. Métodos: Foram selecionados 40 atletas aleatoriamente como voluntários para a pesquisa, divididos em grupo controle e experimental, praticaram o mesmo tipo de exercício físico e com a mesma intensidade. Os atletas do grupo experimental tomaram alimentos em estrita conformidade com a mistura alimentar descrita no artigo, enquanto o grupo de controle manteve sua alimentação regular inalterada. Após o experimento, foi realizado um treinamento esportivo, seguido de aferição da enzima creatina muscular e análise laboratorial de ureia no sangue. Esses dados foram comparados e analisados com os anteriores ao experimento. Resultados: Após o ajuste da estrutura dietética, os índices de CK e Bu dos atletas do grupo experimental mostraram uma tendência descendente, indicando que o ajuste da estrutura nutricional pode efetivamente melhorar a fadiga pós-treino dos atletas universitários. Conclusão: Recomenda-se aos professores de educação física e treinadores universitários ajustarem os hábitos de vida e estrutura alimentar de acordo com a situação real dos alunos, visando a promoção do desenvolvimento integral e melhora no desempenho esportivo. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.

ABSTRACT Insulin antibodies (IAs) induced by exogenous insulin rarely cause hypoglycemia. However, insulin autoantibodies (IAAs) in insulin autoimmune syndrome (IAS) can cause hypoglycemia. The typical manifestations of IAS are fasting or postprandial hypoglycemia, elevated insulin level, decreased C-peptide levels, and positive IAA. We report a 45-year-old male with type 1 diabetes mellitus (T1DM) treated with insulin analogues suffering from recurrent hypoglycemic coma and diabetic ketoacidosis (DKA). His symptoms were caused by exogenous insulin and were similar to IAS. A possible reason was that exogenous insulin induced IA. IA titers were 61.95% (normal: < 5%), and the concentrations of insulin and C-peptide were > 300 mU/L and < 0.02 nmol/L when hypoglycemia occurred. Based on his clinical symptoms and other examinations, he was diagnosed with hyperinsulinemic hypoglycemia caused by IA. His symptoms improved after changing insulin regimens from insulin lispro plus insulin detemir to recombinant human insulin (Gensulin R) and starting prednisone.

Los anticuerpos contra la insulina (AI) inducidos por la insulina exógena raramente causan hipoglucemia. No obstante, los autoanticuerpos contra la insulina (AIA) en el síndrome autoinmune de insulina (SAI) pueden causar hipoglucemia. Las manifestaciones típicas del SAI son la hipoglucemia en ayunas o posprandial, niveles elevados de insulina, la disminución del nivel de péptido C y AIA positivos. Presentamos un paciente hombre de 45 años con diabetes mellitus de tipo 1 (DMT1) tratado con análogos de insulina, que sufría comas hipoglucémicos recurrentes y cetoacidosis diabética (CAD). Sus síntomas fueron causados por la insulina exógena y fueron similares al SAI. La posible razón fue que la insulina exógena indujo AI. El título de AI era del 61,95% (Normal: < 5%), y las concentraciones de insulina y péptido C eran > 300 mU/L y < 0,02 nmol/L cuando se producía la hipoglucemia. Basados en sus síntomas clínicos y otros exámenes, se le diagnosticó hipoglucemia hiperinsulinémica causada por la AI. Sus síntomas mejoraron después de cambiar el régimen de insulina de lispro más insulina detemir a insulina humana recombinante (Gensulin R) y de empezar a tomar prednisona.

Abstract Oxygen glucose deprivation/re-oxygenation (OGD/R)-mediated ischemia of kidney is frequently leads to enhanced apoptosis and amplified inflammatory response. Sappanchalcone (Sap) is a flavonoid compound that extracted from Caesalpinia sappan L. with a range of cell-protective activities. Herein, we primarily reconnoitered the influence of Sap in HK-2 cells under OGD/R treatment. In this research, the consequence revealed that Sap might linked with ischemia of kidney. Besides, Sap lessened OGD/R-mediated HK-2 cell injury by boosting cell viability, inhibiting apoptosis and inflammation. In addition, Sap hindered activation of the TNFRSF1A/NF-kB signaling. Moreover, upregulation of TNFRSF1A diminished the repressive influence of Sap on OGD/R-mediated apoptosis and inflammation. In conclusion, Sap declined the OGD/R-induced HK-2 cell injury by downregulation of TNFRSF1A/NF-kB signaling, thereby offered a theoretical basis for the handling of ischemia of kidney.

SnO2 nanofibers were fabricated by calcination of the electrospun PVP/SnCl4 composite nanofibers. For the first time, SnS nanofibers and SnSe nanofibers were successfully synthesized by double-crucible sulfurization and selenidation methods via inheriting the morphology of SnO2 nanofibers used as precursors, respectively. X-ray diffraction (XRD) analysis shows SnS nanofibers and SnSe nanofibers are respectively pure orthorhombic phase with space group of Pbnm and Cmcm. Scanning electron microscope (SEM) observation indicates that the diameters of SnS nanofibers and SnSe nanofibers are respectively 140.54±12.80 nm and 96.52±14.17 nm under the 95 % confidence level. The photocatalytic activities of samples were studied by using rhodamine B (Rh B) as degradation agent. When SnS or SnSe nanofibers are employed as the photocatalysts, the respective degradation rates of Rh B solution under the ultraviolet light irradiation after 200 min irradiation are 92.55 % and 92.86 %. The photocatalytic mechanism and formation process of SnS and SnSe nanofibers are also provided. More importantly, this preparation technique is of universal significance to prepare other metal chalcogenides nanofibers.

Although titanium (Ti) and its alloys have been widely used as implants in clinical settings, failures still occur mainly due to poor bioactivity and implant-associated infections. Here, we coated Ti implants with TiO2 nanotubes (TNTs) incorporated with the antibacterial agent Ag to produce Ag-TNTs, through anodization in AgNO3 and xenon light irradiation. We characterized surface morphology and composition of the coating with scanning electron microscopy (SEM) and X-ray diffraction (XRD), respectively. We investigated surface topography of the coatings by atomic force microscopy (AFM) operated in the tapping mode. The results indicate that Ag was successfully doped onto the TNTs, and that the nanoparticles were mainly distributed on the surface of TNTs. Finally, our antibacterial experiments reveal that Ag-TNTs on Ti implants exhibit excellent antibacterial activities, which promises to have significant clinical applications as implants.

OBJECTIVES:Our study aimed to investigate the impact of fatigue on the severity of stroke and to explore the underlying mechanisms.METHODS:Fatigued male rats underwent middle cerebral artery occlusion and the infarcted brain area was determined. Then, coagulation parameters were assessed in the fatigued group and a control group. In addition, the level of fibrinogen was determined in rats deprived of sleep for various numbers of days. To study whether interleukin-6 was involved in fibrinogen synthesis during fatigue, we also measured levels of interleukin-6 in rats deprived of sleep for various numbers of days. Furthermore, brain injury by middle cerebral artery occlusion was measured in wild-type mice, interleukin-6-/- mice and wild-type mice treated with bezafibrate.RESULTS:More severe cerebral infarction was observed in the fatigued rats, resulting in an infarct ratio of 23.4%. The infarct ratio was significantly increased in the fatigued rats compared with that in the control group (8%, p<0.05). The level of fibrinogen was increased significantly in the fatigued rats compared with that in the control group. In addition, a marked reduction in fibrinogen level was observed in the fatigued interleukin-6-/- mice compared to their wild-type counterparts, whereas no difference was observed between fatigued wild-type mice and interleukin-6-/- rats treated with recombinant human interleukin-6. The reduction in brain injury due to middle cerebral artery occlusion during fatigue was observed in interleukin-6-/- mice and wild-type mice treated with bezafibrate.CONCLUSION:Fatigue could increase stroke severity and was associated with the interleukin-6-induced expression of fibrinogen.

The polar amino acid, such as aspartic acid (L-Asp) and arginine(L-Arg) are the primary active molecules of the glycoprotein on the organic/inorganic interface of biomineralized tissue. In this study, aspartic acid and arginine were used as the organic template in inducing the nucleation and growth of calcium carbonate. With the analysis of X-ray diffraction we investigated the relationship between amino acid concentration and the precipitation phase crystal structure of calcium carbonate. SEM was employed in the analysis of the morphological characteristic of the precipitation. To interpret the cause of the hierarchic structure was proposed from the view of the small biomolecules polarity that can control over the growth of the crystals and the aggregation of the micro crystals. The conclusion also provides a new material synthesize strategy.

A normalized embryoid cDNA library (EON) was constructed based on reassociation kinetics reaction. Results from dot blot hybridization and sequencing of EON cDNA clones clearly indicated that the normalization process reduced the frequency of high abundance transcripts and increased the frequency of low abundance gene transcripts. A total of 553 non-redundant expressed sequence tags (ESTs) were identified, 325 of these were not observed in the standard oil palm cDNA libraries sequenced previously. A total of 10 EON cDNA clones were chosen for expression profiling across samples from different stages of the tissue culture process. Two of the genes exhibited promising expression patterns for predicting the embryogenic potential in callus. Some of these genes were also differentially expressed in the various tissues of oil palm. This study showed that normalization of the existing embryoid library improved the chances of identifying transcripts not captured in the standard libraries, some of which could be associated with embryogenesis. This collection of ESTs is particularly well suited for use as candidate genes for development of an oil palm DNA chip, which can be used to obtain a more comprehensive view of the molecular mechanism associated with oil palm tissue culture.