Abstract Aim The purpose of this study was to evaluate DHA’s effect and relative mechanisms in diabetic keratopathy (DK) treatment by vitro study. Methods and materials: Using high glucose to make DK cell model; measuring cell apoptosis by flow cytometry and Hoechst 33342 staining; evaluating cell migration abilities by wound healing assay; relative gene and proteins including PEDF, VEGF, Caspase-3, Caspase-9 and NF-κB(p65) expression by RT-qPCR and WB assay; And evaluatign PDEF and p-NF-κB(p65) protein expression by immunofluorescence detection. Results: After high glucose treatment, TKE-2 cell apoptosis was significantly increased and cell migration ability was significantly depressed with PEDF, Caspase-3, Caspase-9 and NF-κB(p65) gene and protein significantly increasing and VEGF expression significantly depressing (P < 0.001, respectively); with DHA supplement, TKE-2 cell biological activities were significantly improved with relative gene and proteins significantly changed; However, with DHA and PEDF supplement, DHA’s treatment was disappeared with PEDF, Caspase-3, Caspase-9 and NF-κB(p65) gene and protein significantly increasing and VEGF expression significantly depressing (P < 0.001, respectively). Conclusion: DHA had effects to improved DK by regulation PEDF pathway in vitro study.

Abstract The fat mass- and obesity-associated gene (FTO) is significantly associated with obesity, but the associations of FTO with obesity-related traits are not fully described. We aimed to investigate the association of the FTO single nucleotide polymorphism (SNP) rs6499640 with lipid levels in Chinese children. A total of 3503 children aged 6-18 years were included in the present study. Lipid levels were analyzed and the SNP rs6499640 was genotyped using the TaqMan Allelic Discrimination Assay. Statistically significant associations were found between rs6499640 and low-density lipoprotein cholesterol (LDL-C) (p = 0.008), total cholesterol (TC) (p = 0.005), and triglycerides (TG) (p < 0.001) in girls under a dominant model adjusted for age and BMI. No statistical significance was found between the SNP and lipid levels in boys. We demonstrated for the first time that the SNP rs6499640 in FTO is associated with LDL-C, TC, and TG in Chinese girls. Our study identified a new risk locus for lipid levels in children.

Using four volume-limited Main galaxy samples of the Sloan Digital Sky Survey Data Release 8 (SDSS DR8), we have investigated the environmental dependences of the SFR, SSFR and stellar mass at fixed luminosity. At fixed luminosity, we still observe strong environmental dependences of the SFR, SSFR and stellar mass of galaxies: galaxies in the lowest density regime preferentially have a higher SFR or SSFR and lower stellar mass than galaxies in the densest regime. This result suggests that the limitation or fixation of luminosity does not exert substantial influence on the environmental dependences of the SFR, SSFR and stellar mass of galaxies, which further shows that luminosity is not a fundamental parameter in correlations between galaxy properties and the environment.

Empleamos cuatro muestras limitadas en volumen de galaxias principales del Sloan Digital Sky Survey, versión 8 (SDSS DR8) para investigar la dependencia del medio ambiente de la tasa de formación estelar (SFR), la tasa específica de formación estelar (SSFR) y la masa en estrellas a una luminosidad fija. Aún fijando la luminosidad, se observa una fuerte dependencia ambiental de la SFR, la SSFR y de la masa en estrellas: las galaxias en la región de más baja densidad tienden a tener mayores SFR y SSFR, y masa en estrellas menores que las galaxias en la región de más alta densidad. Este resultado sugiere que al fijar la luminosidad no se altera apreciablemente la dependencia ambiental de la SFR, la SSFR y la masa en estrellas de las galaxias, lo cual muestra que la luminosidad no es un parámetro fundamental en las correlaciones entre las propiedades galácticas y el ambiente.

Using the volume-limited main galaxy sample constructed from the Sloan Digital Sky Survey Data Release 7 (SDSS DR7), we have explored the environmental dependence of the fraction of 'unconventional' galaxies: luminous late-types and faint early-types. It is found that the fraction of faint early-types increases substantially with increasing local density, and that the fraction of luminous late-types weakly decreases with increasing local density. This shows that there is an environmental dependence for morphology beyond that for luminosity.

Usamos la muestra principal, limitada en volumen, del Sloan Digital Sky Survey Data Release 7 (SDSS DR7), para explorar la dependencia ambiental de la fracción de galaxias 'no convencionales', esto es, galaxias luminosas de tipo tardío, y galaxias débiles de tipo temprano. Encontramos que la fracción de galaxias tempranas débiles aumenta significativamente al aumentar la densidad local, y que la fracción de galaxias tardías luminosas decrece un poco al aumentar la densidad local. Esto muestra que existe una dependencia ambiental de la morfología, además de la luminosidad.

Muitos habitats costeiros vêm sendo alterados substancialmente pela invasão de Spartina alterniflora no leste da China. Em 2007, em uma planície de maré situada em Wenzhou Bay, foram analisadas riqueza de espécies, densidade e diversidade da macrofauna bêntica em relação a diferentes estágios da invasão da gramínea e à estação do ano. Para as medidas de diversidade foram usados os índices de Margalef (R) e de Shannon (H'). Foram detectados efeitos significativos do estágio de invasão e época do ano sobre a macrofauna. As comunidades macrofaunais foram mais complexas nas manchas onde a invasão de S. alterniflora estava no seu início, quando considerados os locais onde as manchas estavam em estágios mais avançados. Através das análises de agrupamento e ordenação as comunidades puderam ser classificadas pelo tipo de habitat formado em cada estágio de invasão da Spartina. Os resultados indicaram que a biodiversidade aumentou no estágio de invasão inicial (idade de invasão de 1 a 2 anos), mas diminuiu gradativamente com os estágios intermediário (idade de invasão de 3 a 4 anos) e completo (idade de invasão de 5 a 6 anos), mostrando assim o efeito deletério de S. alterniflora sobre a estrutura da macrofauna presente no local.

Many coastal habitats in eastern China are being substantially altered by the invasion of Spartina alterniflora. The species richness, density, Margalef's diversity index (R) and Shannon's diversity index (H') of macrobenthic communities on a tidal flat in Wenzhou Bay, China, were analyzed with the factors of invasion stage and season, in 2007. A significant effect of invasion stage, season, and the interaction between them on communities was detected. The macrobenthic community was more complex in the patch of initial S. alterniflora invasion than in the patches of some other invasion stages. Macrobenthic communities were classified by cluster and ordination in accordance with the habitat character of the S. alterniflora invasion stage. Our research demonstrated that the S. alterniflora invasion stage affected the macrobenthic communities significantly. The results indicated that biodiversity increased in the initial stage of invasion (invasion age 1-2 years) and then decreased in the stage of invasion underway (invasion age 3-4 years) and in the stage of invasion completed (invasion age 5-6 years); this phenomenon was related to the change in the S. alterniflora canopy which accompanied the invasion stages.