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Estrategia de cierre con Tecnosoles para la recuperación ambiental de la Mina de São Domingos
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Arán, Diego

; Abreu, Maria Manuela

; Diamantino, Catarina

; Carvalho, Edgar

; Santos, Erika

Revista de Ciências Agrárias

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dec 2022, Volume 45 N. 4 Pages 811 - 820

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen La existencia de minas abandonadas sin gestión ni responsabilidad ambiental, principalmente explotadas antes de los años 80, son un gran problema para las administraciones públicas, cuya prioridad estratégica es minimizar los impactos generados. Bajo este contexto, en la mina de São Domingos (Portugal), la EDM - Empresa de Desemvolvimento Mineiro (EDM) desarrolló un proyecto de recuperación ambiental con aplicación de Tecnosoles, integrando las intervenciones de rehabilitación ambiental definidas en el Plan Director para esta área. Este proyecto permitió evaluar, en un ensayo piloto de 1,5 ha en condiciones de campo, la efectividad a largo plazo (tras 12 meses) de esta tecnología en la mejora de materiales sujetos al lavado contínuo por drenaje ácido. Se implementó una cobertura de 35 cm de Tecnosol, el cual fue diseñado con las propiedades alcalinas y eutróficas en respuesta de la necesidad determinada de los materiales en estudios previos. Tras la aplicación del Tecnosol y siembra de una cobertura de herbáceas, se evaluó la mejora de la calidad físico-química de los Tecnosoles, material de una area control (sin aplicación de Tecnosol) y material subyacente al Tecnosol. También la cobertura vegetal fue evaluada a lo largo del tiempo. Los resultados mostraron que los Tecnosoles son una alternativa eficaz que permite aumentar el pH y la fertilidad, soportar una cobertura vegetal estable y densa, así como reducir en más del 80% la disponibilidad de contaminantes de los materiales contaminados permitiendo obtener zonas para futuros aprovechamientos sin riesgos para el ambiente.

Abstract The existence of abandoned mines without management or environmental responsibility, mainly exploited before the 1980s, is an important problem for public administrations, whose strategic priority is to minimize the impacts generated. In this context, in the São Domingos minining area (Portugal), the EDM - Empresa de Desemvolvimento Mineiro developed a project of environmental rehabilitation with Technosols integrating the environmental rehabilitation interventions defined in the Master Plan for this large area. This project allowed the evaluation, in pilot assay with 1.5 ha and under field conditions, the long-term effectiveness (after 12 months) of this technology. A layer with 35 cm of Technosol, which was designed with alkaline and eutrophic properties due to the needs of the materials, was applied. After the Technosol application and herbaceous sowing, the physical-chemical quality of the Technosols, material from a control area (without Technosol application) and contaminated material located below the Technosol was evaluated. The results showed that Technosols are an effective alternative that allows the increasing of the pH and fertility, support a dense and stable plant cover as well as the diminution (more than 80 %) of the availability of contaminants from the contaminated materials, allowing future land uses (agricultural, forestry, etc.) without environmental risk.

https://doi.org/10.19084/rca.28634

Radiographic aspects in individuals infected by human T-lymphotropic virus type 1 (HTLV-1) with joint pain
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Carvalho, João Marcos da Silva

; Campos, Eugênia Maria Teixeira de Araújo

; Ferreira, José Luiz Nunes

; Carvalho, Huliana Mourão

; Carneiro Neto, José Abraão

; Carneiro, Tássila de Oliveira

; Carvalho, Edgar Marcelino

Advances in Rheumatology

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2022, Volume 62 elocation 31

Abstract: En | Text: En | PDF: En

Abstract Background: Joint pain in the absence or with little synovitis is observed in a large percentage of HTLV-1 infected subjects. As the virus infect CD4 +and CD8 +positive, macrophages and B cells an exaggerated production of pro-inflammatory cytokines is detected in these patients. However, the possible association of HTLV-1 infection with autoimmune diseases has not been documented definitively and the clinical characteristics of HTLV-1 associated arthropathy has not been defined. The objective this study is to describe clinic and radiographic features in HTLV-1-infected individuals with complaints of joint pain. Methods: Cross-sectional study enrolling HTLV-1-infected individuals with chronic joint pain, aged up to 75 years, both genders and seronegative controls with osteoarthritis. All participants underwent conventional radiography of the hips, knees and ankles. Results: Eighty-one HTLV-1 infected patients and 30 subjects with osteoarthritis participated in the study. Polyarticular and symmetrical arthritis prevailed in the HTLV-1 positive group (54%), while oligoarticular and asymmetrical (44%) were more common in controls ( p < 0.05). The frequency of enthesophytes (90%) in HTLV-1-infected patients was greater than in the control group (73%) ( p < 0.05). Radiographic features were similar in HTLV-1 carriers and in patients with probable or definite HTLV-1 associated myelopathy. The presence of enthesophytes in the absence of joint space reduction or osteophytes was only observed in HTLV-1-infected individuals ( p < 0.001). Magnetic resonance imaging of the ankles of five HTLV-1-infected patients and five controls demonstrated a higher frequency of enthesitis, bursitis and osteitis in the HTLV-1 infected group. Conclusion: HTLV-1-associated arthropathy is clinically characterized by symmetrical polyarthralgia and the main radiological finding is the presence of enthesophytes in the absence of osteophytes and joint space narrowing.

https://doi.org/10.1186/s42358-022-00259-y

Prevalence of Bowel Symptoms in Patients Infected with Human T-Lymphotropic type 1 Virus
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Oliveira, Tatiane Souza Soares

; Andrade, Rosana Cristina Pereira de

; Santos, Dislene Nascimento dos

; Orrico, Keith Froes

; Abraão Neto, José

; Oliveira, Cassius José Vitor de

; Rocha, Paulo Novis

; Carvalho, Edgar Marcelino de

Revista da Sociedade Brasileira de Medicina Tropical

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2019, Volume 52 elocation e20180486

Abstract: En | Text: En | PDF: En

Abstract INTRODUCTION: Bowel dysfunction is frequent in patients with spinal cord diseases, but little is known about the prevalence of bowel symptoms in human T-lymphotropic virus-(HTLV-1) infected individuals. The purpose of this study is to determine the frequency of bowel symptoms in HTLV-1 infected individuals and their correlation with the degree of neurologic disease. METHODS: This is a cross-sectional study comparing the frequency of bowel symptoms in HTLV-1-infected individuals* and seronegative donors (controls). Patients answered a questionnaire, the Rome III Criteria was applied, and stool consistency was evaluated by the Bristol Stool Form Scale. The individuals were classified as HTLV-1 carriers, probable HTLV-1 myelopathy and definitive HTLV-1 associated myelopathy or tropical spastic paraparesis (definitive HAM / TSP)**. RESULTS: We studied 72 HTLV-1 infected individuals and 72 controls with equal age and gender distribution. Constipation was the most frequent complaint, occurring in 38 % of HTLV-1 individuals and in 15 % of the controls. In comparison to the seronegative controls, the probability of constipation occurrence was approximately 18 times higher in definitive HAM / TSP patients. Straining, lumpy or hard stools, sensation of anorectal obstruction/blockage, fewer than 3 defecations per week, flatulence, soiling, evacuation pain, and bleeding were also more frequent in the HTLV-1 patients than in the controls. Moreover, bowel symptoms were more frequent in patients with definitive or probable HAM / TSP than in carriers. CONCLUSIONS: Bowel symptoms were more frequent in HTLV-1-infected patients than in seronegative controls and the frequency of bowel symptoms correlated with the severity of neurologic disease.

https://doi.org/10.1590/0037-8682-0486-2018 926 downloads

Increasing awareness of human T-lymphotropic virus type-1 infection: a serious, invisible, and neglected health problem in Brazil
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Puccioni-Sohler, Marzia

; Grassi, Maria Fernanda Rios

; Galvão-Castro, Bernardo

; Caterino, Adele

; Proietti, Anna Bárbara de Freitas Carneiro

; Vicente, Ana Carolina Paulo

; Galvão-Castro, Ana Verena

; Vallinoto, Antonio Carlos

; Paiva, Arthur

; Penalva, Augusto

; Rosadas, Carolina

; Miyashiro, Denis

; Barbosa, Edel Figueiredo

; Carvalho, Edgar Marcelino de

; Batista, Everton da Silva

; Smid, Jerusa

; Casseb, Jorge

; Vidal, Jose

; Sousa, Maisa Silva

; Viana, Maria Graça de Castro

; Bastos, Michele de Souza

; Lírio, Monique

; Boa-Sorte, Ney

; Ferreira Jr, Orlando C.

; Takayanagui, Osvaldo

; Moura, Patrícia

; Rocco, Regina

; Cunha, Rodrigo Guimaraes

; Haddad, Simone Kashima

; Assone, Tatiane

; Araújo, Thessika Hialla Almeida

Revista da Sociedade Brasileira de Medicina Tropical

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2019, Volume 52 elocation e20190343

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/0037-8682-0343-2019 953 downloads

Polymorphism in the interleukin-10 gene is associated with overactive bladder phenotype associated with HTLV-1 infection
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Braz, Marcos

; Oliveira, Joyce Moura

; Rêgo, Jamile Leão

; Carvalho, Edgar Marcelino de

; Santos, Silvane Maria Braga

; Castellucci, Léa Cristina

Revista da Sociedade Brasileira de Medicina Tropical

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2019, Volume 52 elocation e20180481

Abstract: En | Text: En | PDF: En

Abstract INTRODUCTION Human T-cell lymphotropic virus type 1 (HTLV-1)-associated inflammatory diseases are not well understood; however, their clinical manifestations may be influenced by the host genetic background. METHODS We genotyped 298 individuals with HTLV-1 and 380 controls for interleukin-10 (IL10) gene variants-rs3024496, rs1800871, rs1800896-and used logistic regression analysis to determine their association with clinical phenotypes. RESULTS No association with HTLV-1 infection was observed. However, allele A of rs1800896 (1082bp upstream) was associated with protection against neurological impairment, specifically overactive bladder (OR=0.447, 95% CI 0.28-0.70, p=0.001). CONCLUSIONS Our data suggests that IL10 regulation ameliorates neurological damage in HTLV-1 infections.

https://doi.org/10.1590/0037-8682-0481-2018 637 downloads

The relationship between atopy and neurological manifestations in HTLV-1 infection
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Verde, Raquel Crisóstomo Lima

; Carneiro Neto, José Abraão

; Santos, Silvane Maria Braga

; Carvalho, Edgar Marcelino

; Lessa, Marcus Miranda

Revista da Sociedade Brasileira de Medicina Tropical

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apr 2018, Volume 51 N. 2 Pages 207 - 211

Abstract: En | Text: En | PDF: En

Abstract INTRODUCTION: Human T-cell lymphotropic virus type 1 (HTLV-1)induces exaggerated Th1 responses, whereas atopy is associated with exacerbated Th2 responses. METHODS: Here, a cross-sectional study compared the prevalence of atopy in HTLV-1 carriers and HAM/TSP patients. It also compared the spontaneous cytokine production in HTLV-1-infected individuals. A retrospective cohort study evaluated the development of neurological manifestations in atopic and non-atopic carriers. RESULTS: Atopic HAM/TSP patients with high IFN-γ production exhibited higher IL-5 levels than non-atopic patients. Allergic rhinitis accelerated the development of Babinski signals and overactive bladders. CONCLUSIONS: Abnormal Th1 and Th2 responses coexist in HTLV-1-infected individuals and allergic diseases may worsen the clinical course of HTLV-1 infections.

https://doi.org/10.1590/0037-8682-0162-2017 847 downloads

Onabotulinumtoxin type A improves lower urinary tract symptoms and quality of life in patients with human T cell lymphotropic virus type 1 associated overactive bladder
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Carneiro Neto, Jose Abraão

; Santos, Silvane Braga

; Orge, Gloria Orge

; Tanajura, Davi

; Passos, Lucia

; Oliveira, Cassius José

; Andrade, Rosana

; Melo, Cláudio Galeno de

; Barroso Jr, Ubirajara

; Carvalho, Edgar M.

Brazilian Journal of Infectious Diseases

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mar 2018, Volume 22 N. 2 Pages 79 - 84

Abstract: En | Text: En | PDF: En

ABSTRACT Aim: To evaluate the efficacy of the onabotulinum toxin type A in the treatment of HTLV-1 associated overactive bladder and its impact on quality of life (QoL). Methods: Case series with 10 patients with overactive bladder refractory to conservative treatment with anticholinergic or physical therapy. They received 200Ui of onabotulinumtoxin type A intravesically and were evaluated by overactive bladder symptoms score (OABSS) and King's Health Questionnaire. Results: The mean (SD) of the age was 52 + 14.5 years and 60% were female. All of them had confirmed detrusor overactivity on urodynamic study. Seven patients had HAM/TSP. The median and range of the OABSS was 13 (12–15) before therapy and decreased to 1.0 (0–12) on day 30 and to 03 (0–14) on day 90 (p < 0.0001). There was a significant improvement in 8 of the 9 domains of the King's Health Questionnaire after the intervention. Hematuria, urinary retention and urinary infection were the complications observed in 3 out of 10 patients. The mean time to request retreatment was 465 days. Conclusion: Onabotulinum toxin type A intravesically reduced the OABSS with last long effect and improved the quality of life of HTLV-1 infected patients with severe overactive bladder.

https://doi.org/10.1016/j.bjid.2017.10.009 545 downloads

Mucosal leishmaniasis: urgent need for more research
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Carvalho, Edgar Marcelino

; Llanos-Cuentas, Alejandro

; Romero, Gustavo Adolfo Sierra

Revista da Sociedade Brasileira de Medicina Tropical

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feb 2018, Volume 51 N. 1 Pages 120 - 121

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/0037-8682-0463-2017 1884 downloads

Inflammatory and immunological profiles in patients with COPD: relationship with FEV 1 reversibility
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Queiroz, Cleriston Farias

; Lemos, Antonio Carlos Moreira

; Bastos, Maria de Lourdes Santana

; Neves, Margarida Célia Lima Costa

; Camelier, Aquiles Assunção

; Carvalho, Natália Barbosa

; Carvalho, Edgar Marcelino de

Jornal Brasileiro de Pneumologia

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aug 2016, Volume 42 N. 4 Pages 241 - 247

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Determinar se a gravidade da DPOC se correlaciona com a contagem de células no escarro, atopia e asma. Métodos: Estudo transversal com 37 pacientes com DPOC e 22 indivíduos saudáveis com função pulmonar normal (controles). As contagens de células no escarro foram determinadas por microscopia após a centrifugação das amostras. Foram realizados testes cutâneos de puntura, e as citocinas séricas foram determinadas por ELISA. Resultados: Os pacientes foram estratificados pela resposta ao broncodilatador: o grupo de limitação ao fluxo aéreo não reversível (LFAnr) envolveu 24 pacientes sem alteração significativa do VEF1 pós-broncodilatador, e o grupo de limitação ao fluxo aéreo parcialmente reversível (LFApr) envolveu 13 pacientes com reversibilidade do VEF1 (aumento do VEF1 pós-broncodilatador ≥ 12%). A proporção de eosinófilos no escarro foi maior no grupo LFApr do que no LFAnr (p < 0,01), e houve uma correlação inversa entre a proporção de eosinófilos e VEF1 (p < 0,05). Entretanto, nenhum dos pacientes apresentou histórico de asma e os resultados dos testes cutâneos não diferiram entre os dois grupos. Nas amostras de escarro dos pacientes, os neutrófilos predominaram. Os níveis séricos de TNF, IL-6, IL-8 e RANTES (CCL5) foram maiores nos pacientes que nos controles (p < 0,001), mas não diferiram entre os dois grupos de pacientes. Conclusões: Pacientes com DPOC e reversibilidade parcial do VEF1 parecem apresentar maiores contagens de eosinófilos no escarro e maior hiper-responsividade das vias aéreas que aqueles sem reversibilidade do VEF1. Entretanto, a gravidade da DPOC não se correlacionou com atopia ou perfil das citocinas.

ABSTRACT Objective: To determine whether COPD severity correlates with sputum cell counts, atopy, and asthma. Methods: This was a cross-sectional study involving 37 patients with COPD and 22 healthy subjects with normal lung function (controls). Sputum cell counts were determined by microscopy after centrifugation of samples. Skin prick tests were performed, and serum cytokines were determined by ELISA. Results: Patients were stratified by bronchodilator response: a non-reversible airflow limitation (nonRAL) group comprised 24 patients showing no significant post-bronchodilator change in FEV1; and a partially reversible airflow limitation (partialRAL) group comprised 13 patients showing FEV1 reversibility (post-bronchodilator FEV1 increase ≥ 12%). The proportion of eosinophils in sputum was higher in the partialRAL group than in the nonRAL group (p < 0.01), and there was an inverse correlation between the proportion of eosinophils and FEV1 (p < 0.05). However, none of the patients had a history of asthma and skin prick test results did not differ between the two groups. In the patient sputum samples, neutrophils predominated. Serum levels of TNF, IL-6, IL-8, and RANTES (CCL5) were higher in patients than in controls (p < 0.001) but did not differ between the two patient groups. Conclusions: COPD patients with partial FEV1 reversibility appear to have higher sputum eosinophil counts and greater airway hyperresponsiveness than do those with no FEV1 reversibility. However, we found that COPD severity did not correlate with atopy or with the cytokine profile.

https://doi.org/10.1590/s1806-37562015000000122 5621 downloads

10.

The microbiological signature of human cutaneous leishmaniasis lesions exhibits restricted bacterial diversity compared to healthy skin
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Salgado, Vanessa R

; Queiroz, Artur TL de

; Sanabani, Sabri S

; Oliveira, Camila I de

; Carvalho, Edgar M

; Costa, Jackson ML

; Barral-Netto, Manoel

; Barral, Aldina

Memórias do Instituto Oswaldo Cruz

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apr 2016, Volume 111 N. 4 Pages 241 - 251

Abstract: En | Text: En | PDF: En

Localised cutaneous leishmaniasis (LCL) is the most common form of cutaneous leishmaniasis characterised by single or multiple painless chronic ulcers, which commonly presents with secondary bacterial infection. Previous culture-based studies have found staphylococci, streptococci, and opportunistic pathogenic bacteria in LCL lesions, but there have been no comparisons to normal skin. In addition, this approach has strong bias for determining bacterial composition. The present study tested the hypothesis that bacterial communities in LCL lesions differ from those found on healthy skin (HS). Using a high throughput amplicon sequencing approach, which allows for better populational evaluation due to greater depth coverage and the Quantitative Insights Into Microbial Ecology pipeline, we compared the microbiological signature of LCL lesions with that of contralateral HS from the same individuals.Streptococcus, Staphylococcus,Fusobacterium and other strict or facultative anaerobic bacteria composed the LCL microbiome. Aerobic and facultative anaerobic bacteria found in HS, including environmental bacteria, were significantly decreased in LCL lesions (p < 0.01). This paper presents the first comprehensive microbiome identification from LCL lesions with next generation sequence methodology and shows a marked reduction of bacterial diversity in the lesions.

https://doi.org/10.1590/0074-02760150436 2258 downloads

11.

The use of botulinum toxin type A in the treatment of HTLV-1-associated overactive bladder refractory to conventional therapy
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Carneiro Neto, José Abraão

; Bittencourt, Valéria Gusmão

; de Oliveira, Cassius

; Andrade, Rosana

; de Carvalho, Edgar Marcelino

Revista da Sociedade Brasileira de Medicina Tropical

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aug 2014, Volume 47 N. 4 Pages 528 - 532

Abstract: En | Text: En | PDF: En

Urinary symptoms occur in 19% of human T-cell lymphotropic virus type 1 (HTLV-1)-infected patients who do not fulfill criteria for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and in almost 100% of HAM/TSP patients. Few studies have evaluated therapies for overactive bladder (OAB) caused by HTLV-1 infection. This case report describes the effect of onabotulinum toxin A on the urinary manifestations of three patients with HAM/TSP and OAB symptoms. The patients were intravesically administered 200 units of Botox®. Their incontinence episodes improved, and their OAB symptoms scores (OABSS) reduced significantly. These data indicate that Botox® should be a treatment option for OAB associated with HTLV-1 infection.

https://doi.org/10.1590/0037-8682-0029-2014 2601 downloads

12.

Host genetic factors in American cutaneous leishmaniasis: a critical appraisal of studies conducted in an endemic area of Brazil
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Castellucci, Léa Cristina

; Almeida, Lucas Frederico de

; Jamieson, Sarra Elisabeth

; Fakiola, Michaela

; Carvalho, Edgar Marcelino de

; Blackwell, Jenefer Mary

Memórias do Instituto Oswaldo Cruz

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jun 2014, Volume 109 N. 3 Pages 279 - 288

Abstract: En | Text: En | PDF: En

American cutaneous leishmaniasis (ACL) is a vector-transmitted infectious disease with an estimated 1.5 million new cases per year. In Brazil, ACL represents a significant public health problem, with approximately 30,000 new reported cases annually, representing an incidence of 18.5 cases per 100,000 inhabitants. Corte de Pedra is in a region endemic for ACL in the state of Bahia (BA), northeastern Brazil, with 500-1,300 patients treated annually. Over the last decade, population and family-based candidate gene studies were conducted in Corte de Pedra, founded on previous knowledge from studies on mice and humans. Notwithstanding limitations related to sample size and power, these studies contribute important genetic biomarkers that identify novel pathways of disease pathogenesis and possible new therapeutic targets. The present paper is a narrative review about ACL immunogenetics in BA, highlighting in particular the interacting roles of the wound healing gene FLI1 with interleukin-6 and genes SMAD2 and SMAD3 of the transforming growth factor beta signalling pathway. This research highlights the need for well-powered genetic and functional studies on Leishmania braziliensis infection as essential to define and validate the role of host genes in determining resistance/susceptibility regarding this disease.

https://doi.org/10.1590/0074-0276140028 2455 downloads Cited 2 times in SciELO

13.

Comparative analysis of the tissue inflammatory response in human cutaneous and disseminated leishmaniasis
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Dantas, Marina Loyola

; Oliveira, Juliana Menezes Gomes Cabral de

; Carvalho, Lucas

; Passos, Sara Timóteo

; Queiroz, Adriano

; Guimarães, Luiz Henrique

; Machado, Paulo

; Carvalho, Edgar

; Arruda, Sérgio

Memórias do Instituto Oswaldo Cruz

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apr 2014, Volume 109 N. 2 Pages 202 - 209

Abstract: En | Text: En | PDF: En

Cutaneous leishmaniasis (CL) is the most frequent clinical form of tegumentary leishmaniasis and is characterised by a single or a few ulcerated skin lesions that may disseminate into multiple ulcers and papules, which characterise disseminated leishmaniasis (DL). In this study, cells were quantified using immunohistochemistry and haematoxylin and eosin staining (CD4+, CD68+, CD20+, plasma cells and neutrophils) and histopathology was used to determine the level of inflammation in biopsies from patients with early CL, late CL and DL (ulcers and papules). The histopathology showed differences in the epidermis between the papules and ulcers from DL. An analysis of the cells present in the tissues showed similarities between the ulcers from localised CL (LCL) and DL. The papules had fewer CD4+ T cells than the DL ulcers. Although both CD4+ cells and macrophages contribute to inflammation in early CL, macrophages are the primary cell type associated with inflammation intensity in late ulcers. The higher frequency of CD20+ cells and plasma cells in lesions demonstrates the importance of B cells in the pathogenesis of leishmaniasis. The number of neutrophils was the same in all of the analysed groups. A comparison between the ulcers from LCL and DL and the early ulcers and papules shows that few differences between these two clinical forms can be distinguished by observing only the tissue.

https://doi.org/10.1590/0074-0276130312 2586 downloads

14.

Comment: seroprevalence of HTLV-1/2 among blood donors in the state of Maranhão, Brazil
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Carvalho, Edgar M.

Revista Brasileira de Hematologia e Hemoterapia

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jan 2014, Volume 36 N. 1 Pages 12 - 13

Abstract: En | Text: En | PDF: En

https://doi.org/10.5581/1516-8484.20140006 699 downloads

15.

CD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasis
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Dantas, Marina Loyola

; Oliveira, Juliana Cabral de

; Carvalho, Lucas

; Passos, Sara Timoteo

; Queiroz, Adriano

; Machado, Paulo

; Carvalho, Edgar

; Arruda, Sergio

Revista da Sociedade Brasileira de Medicina Tropical

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dec 2013, Volume 46 N. 6 Pages 728 - 734

Abstract: En | Text: En | PDF: En

Introduction Leishmania braziliensis infection induces a large spectrum of lesions that clinically manifest as nodules or papules that progress to ulcers. Although it is already known that T helper cells predominate in the lesions, cytotoxic T cells have also been reported to be present, and their role in leishmaniasis immunopathogenesis is not well known. This study investigated the amounts of CD8+ and granzyme B+ cells in different clinical forms of human cutaneous leishmaniasis (CL). Methods Forty tissue fragments from early (E-CL) and late CL (L-CL) lesions and from disseminated leishmaniasis (DL) - papules and ulcers - were characterized. The inflamed area per fragment was calculated, and the CD8 and granzyme B expression levels in the infiltrates were quantified by counting positive cells in 15 fields. The localization of CD8 and granzyme B was graded subjectively. Results Inflammation was higher in L-CL and DL ulcers. CD8 expression was increased in late ulcerated lesions compared to recent lesions. The increase in CD8+ cells also correlated with the duration of the lesion. Papules had a higher frequency of granzyme B+ cells than E-CL lesions, although the frequency was similar to those for late and DL ulcers. CD8+ cells were mostly found in the papillary dermis. Conclusions CD8+ T and granzyme B+ cells are present in the inflammatory infiltrates of CL and DL and may participate in the immunopathogenesis of Leishmania infection.

https://doi.org/10.1590/0037-8682-0174-2013 3730 downloads Cited 1 time in SciELO

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