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SUMMARY Hemangioblastomas associated with von Hippel-Lindau (VHL) disease are frequently multiple and recur during prolonged follow-up. Currently, no systemic treatment is available for these tumors. Recent studies have shown the expression of somatostatin receptors in these types of hemangioblastomas. Notably, increased somatostatin receptor expression in a tumor, as determined by peptide-receptor radionuclide imaging, is a predictive factor of response to treatment with somatostatin analogs and peptide-receptor radionuclide therapy. The aim of this study was to describe the case of a patient with increased expression of somatostatin receptors in a suprasellar hemangioblastoma associated with VHL disease and conduct a literature review on somatostatin receptor expression in patients with VHL-associated hemangioblastomas. We describe herein the case of a 51-year-old man with VHL disease who had a suprasellar hemangioblastoma detected on magnetic resonance imaging. Peptide-receptor radionuclide imaging using gallium-68-DOTATOC (68Ga-DOTATOC) identified increased expression of somatostatin receptors in the suprasellar hemangioblastoma, along with multiple pancreatic neuroendocrine tumors and bilateral pheochromocytomas. The patient was treated for 1 year with lanreotide, a somatostatin analog. A repeat 68Ga-DOTATOC 1 year after starting lanreotide revealed decreased radiotracer uptake by the hemangioblastoma, consistent with a metabolic response. The presence of somatostatin receptors in hemangioblastomas associated with VHL disease is a novel finding. The decreased expression of these receptors after treatment with a somatostatin analog, as described in the present case, positions the somatostatin receptor as a new target for novel diagnostic, therapeutic, and follow-up opportunities in patients with VHL disease. HippelLindau Hippel Lindau (VHL followup. followup follow up. up Currently Notably tumor peptidereceptor peptide therapy VHLassociated 51yearold yearold 51 old Peptidereceptor Peptide gallium68DOTATOC galliumDOTATOC gallium 68 DOTATOC 68GaDOTATOC GaDOTATOC 68Ga Ga (68Ga-DOTATOC pheochromocytomas analog finding diagnostic therapeutic 5 6

https://doi.org/10.20945/2359-4292-2023-0181

Preoperative evaluation of prostate cancer by 68Ga-PMSA positron emission tomography/computed tomography: comparison with magnetic resonance imaging and with histopathological findings
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Stasiak, Camila Edith Stachera

; Cardillo, Athos

; Almeida, Sergio Altino de

; Rodrigues, Rosana Souza

; Castro, Paulo Henrique Rosado de

; Parente, Daniella Braz

Radiologia Brasileira

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2023, Volume 56 N. 4 Pages 171 - 178

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Objective: To evaluate the accuracy of preoperative positron emission tomography/computed tomography with 68Ga-labeled prostate-specific membrane antigen (68Ga-PSMA PET/CT) for staging prostate cancer and compare it with magnetic resonance imaging (MRI) using histopathology of surgical specimens as the gold standard. Materials and Methods: In this retrospective study, 65 patients with prostate cancer were analyzed. Results: The accuracy of 68Ga-PSMA PET/CT for tumor detection was 95%, and that of MRI was 91%. There was no difference between 68Ga-PSMA PET/CT and MRI regarding localization of the lesion. The sensitivity of 68Ga-PSMA PET/CT for detecting extraprostatic extension was quite low (14%). For detection of seminal vesicle invasion, 68Ga-PSMA PET/CT showed a sensitivity of 57% and accuracy of 91%. There was a moderate correlation between the maximum standardized uptake value (SUVmax) and the serum level of prostate-specific antigen (p < 0.01; ρ = 0.368) and between the SUVmax and the International Society of Urological Pathology (ISUP) grade (p < 0.01; ρ = 0.513). Conclusion: 68Ga-PSMA PET/CT is a promising tool for detecting and evaluating the primary tumor, which can alter the staging and management of the disease.

Resumo Objetivo: Avaliar a acurácia da tomografia por emissão de pósitrons/tomografia computadorizada com PSMA (PET-PMSA) pré-operatória para estadiamento do câncer de próstata e compará-la com a ressonância magnética (RM) utilizando o histopatológico cirúrgico como padrão ouro. Materiais e Métodos: Neste estudo retrospectivo foram analisados 65 pacientes com câncer de próstata. Resultados: A acurácia da PET-PSMA para a detecção tumoral foi de 95% e a da RM foi de 91%. Não houve diferença entre a PET-PSMA e a RM quanto à localização da lesão. A PET-PSMA apresentou baixa sensibilidade (14%) para detecção de extensão extraprostática em comparação ao histopatológico. Para detecção de invasão de vesícula seminal, a PET-PSMA apresentou sensibilidade de 57% e acurácia de 91% em comparação ao histopatológico. Houve correlação moderada entre o SUVmax e o PSA (p < 0,01; ρ = 0,368) e entre o SUVmax e o ISUP (p < 0,01; ρ = 0,513). Conclusão: A PET-PSMA é uma ferramenta promissora para detecção e avaliação do tumor primário, alterando o estadiamento e a conduta do paciente.

https://doi.org/10.1590/0100-3984.2022.0122-en

Severe acute respiratory syndrome coronavirus 2 infection among healthcare workers in a tertiary public hospital in Curitiba, Brazil
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Spalanzani, Regiane Nogueira

; Genelhoud, Gustavo

; Raboni, Sonia Mara

; Almeida, Sergio Monteiro de

; Pereira, Luciane Aparecida

; Rotta, Indianara

; Cavalli, Barbara Maria

; Moreira, Francielli Brusco

; Dino, Carolina Lumi Tanaka

; Takahashi, Gislene Reche de Almeida

; Cognialli, Regielly Caroline Raimundo

; Spiri, Beatriz Sanada

; Bochnia-Bueno, Lucas

; Oliveira, Jaqueline Carvalho de

; Adamoski, Douglas

; Gradia, Daniela Fiori

; Bonatto, Ana Cláudia

; Wassem, Roseli

; Alves, Juliana Mazini

; Padilha, Raquel da Silva

; Brasil, Vitor Jorge Woytuski

; Almeida, Bernardo Montesanti Machado de

; Nogueira, Meri Bordignon

Revista da Sociedade Brasileira de Medicina Tropical

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2022, Volume 55 elocation e0265-2021

Abstract: En | Text: En | PDF: En

ABSTRACT BACKGROUND: We aimed to describe the clinical characteristics of coronavirus disease 2019 (COVID-19) among healthcare workers (HCWs) in Curitiba, Brazil. METHODS: Upper respiratory samples from 1077 HCWs were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using reverse transcription polymerase chain reaction from June 16, 2020 to December 9, 2020. RESULTS: Overall, 32.7% of HCWs were infected. The positivity rates in symptomatic and asymptomatic HCWs were 39.2% and 15.9%, respectively. Hospital departments categorized as high-risk for exposure had the highest number of infected HCWs. CONCLUSIONS: Early diagnosis and isolation of infected HCWs remain key in controlling SARS-CoV-2 transmission because HCWs in close contact with COVID-19 patients are more likely to be infected than those who are not.

https://doi.org/10.1590/0037-8682-0265-2021

Diagnostic characteristics of Xpert MTB/RIF assay for the diagnosis of tuberculous meningitis and rifampicin resistance in Southern Brazil MTBRIF MTB RIF
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de Almeida, Sergio Monteiro

; Kussen, Gislene Maria Botão

; Cogo, Laura

; Carvalho, José Henrique

; Nogueira, Keite

Arquivos de Neuro-Psiquiatria

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nov 2020, Volume 78 N. 11 Pages 700 - 707

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: O diagnóstico da meningite tuberculosa (TBM) é desafiador. Ferramentas de diagnóstico molecular são necessárias para esse diagnóstico, particularmente em países de baixa e média renda. Objetivos: Calcular as características diagnósticas do Xpert MTB/RIF para a detecção de Mycobacterium tuberculosis no líquido cefalorraquidiano (LCR) e a frequência de resistência à rifampicina (RIF) nas amostras do LCR. Métodos: Um total de 313 amostras consecutivas de LCR foram estudadas e categorizadas em casos de TBM definida, provável, possível ou não TBM, com base nos dados clínicos, laboratoriais e de imagem. Resultados: Para os casos definidos de TBM (n=7), sensibilidade, especificidade, eficiência e razão de verossimilhança positiva foram de 100, 97, 97 e 38%, respectivamente. No entanto, para os casos de TBM definidos associados aos prováveis (n=24), a sensibilidade diminuiu para 46%. Todas as amostras de LCR que foram positivas para Xpert MTB/RIF foram suscetíveis a RIF. Conclusão: O Xpert MTB/RIF mostrou alto valor discriminante entre os casos TBM comprovados por microbiologia, porém o valor nos casos prováveis e possíveis de TBM foram reduzidos. O Xpert MTB/RIF contribui significativamente para o diagnóstico de TBM, principalmente quando associado aos testes microbiológicos convencionais e algoritmos clínicos. Introdução (TBM desafiador renda Objetivos MTBRIF MTB RIF (LCR (RIF Métodos 31 definida provável clínicos imagem Resultados n=7, n7 n n=7 , 7 (n=7) especificidade 100 9 38 38% respectivamente entanto n=24, n24 n=24 24 (n=24) 46 46% Conclusão microbiologia reduzidos 3 n= (n=7 10 n2 n=2 2 (n=24 4 (n= 1 (n=2 (n

ABSTRACT Background: The timely diagnosis of tuberculous meningitis (TBM) is challenging. Molecular diagnostic tools are necessary for TBM, particularly in low- and middle-income countries. Objectives: We aimed to calculate the diagnostics characteristics of Xpert MTB/RIF for the detection of Mycobacterium tuberculosis in the cerebrospinal fluid (CSF) and the frequency of rifampicin (RIF)-resistance in the CSF samples. Methods: A total of 313 consecutive CSF samples were studied and categorized into TBM definite, probable, possible, or not TBM cases based on the clinical, laboratory, and imaging data. Results: For the definite TBM cases (n=7), the sensitivity, specificity, efficiency, and positive likelihood ratio were 100, 97, 97, and 38%, respectively. However, for the TBM definite associated with the probable cases (n=24), the sensitivity decreased to 46%. All CSF samples that were Xpert MTB/RIF-positive were RIF susceptible. Conclusion: Xpert MTB/RIF showed high discriminating value among the microbiology-proven TBM cases, although the values for the probable and possible TBM cases were reduced. Xpert MTB/RIF contributes significantly to the diagnosis of TBM, mainly when coupled with the conventional microbiological tests and clinical algorithms. Background (TBM challenging low middleincome middle income countries Objectives MTBRIF MTB (CSF RIFresistance resistance Methods 31 laboratory data Results n=7, n7 n n=7 , 7 (n=7) specificity efficiency 100 97 38 38% respectively However n=24, n24 n=24 24 (n=24) 46 46% MTB/RIFpositive MTBRIFpositive susceptible Conclusion microbiologyproven microbiology proven reduced algorithms 3 n= (n=7 10 9 n2 n=2 2 (n=24 4 RIFpositive (n= 1 (n=2 (n

https://doi.org/10.1590/0004-282x20200067 810 downloads

[SciELO Preprints] - Neurological complications in patients with SARS-CoV-2 infection: a systematic review
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Munhoz, Renato Puppi Pedroso, José Luiz Nascimento, Fábio Augusto Almeida, Sergio Monteiro de Barsottini, Orlando Graziani Povoas Cardoso, Francisco Eduardo Teive, Hélio A Ghizoni

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Publication date: 2020-05-15

Abstract: En Pt

Background: As the COVID-19 pandemic unfolds worldwide, different forms of reports have described its neurologic manifestations. Objective: To review the literature on neurological complications of SARS-CoV-2 infection. Methods: Literature search performed following systematic reviews guidelines, using specific keywords based on the COVID-19 neurological complications described up to May 10th, 2020. Results: A total of 43 articles were selected, including data ranging from common, non-specific symptoms, such as hyposmia and myalgia, to more complex and life-threatening conditions, such as cerebrovascular diseases, encephalopathies, and Guillain-Barré syndrome. Conclusion: Recognition of neurological manifestations of SARS-CoV-2 should be emphasized despite the obvious challenges faced by clinicians caring for critical patients who are often sedated and presenting other concurrent systemic complications.

Introdução: À medida que a pandemia da COVID-19 se desenvolve em todo o mundo, diferentes tipos de publicações descreveram suas manifestações neurológicas. Objetivo: Revisar a literatura sobre complicações neurológicas da infecção por SARS-CoV-2. Métodos: A pesquisa bibliográfica foi realizada seguindo diretrizes de revisões sistemáticas, usando palavras-chave específicas baseadas nas complicações neurológicas da COVID-19 descritas até 10 de maio de 2020. Resultados: Foram selecionados 43 artigos, incluindo descrições que variam de sintomas comuns e inespecíficos, como hiposmia e mialgia, a condições mais complexas e com risco de vida, como doenças cerebrovasculares, encefalopatias e síndrome de Guillain-Barré. Conclusão: O reconhecimento das manifestações neurológicas da SARS-CoV-2 deve ser enfatizado apesar dos óbvios desafios enfrentados pelos clínicos que cuidam de pacientes críticos, muitas vezes sedados e apresentando outras complicações sistêmicas concomitantes.

https://doi.org/10.1590/0004-282X20200051

Neurological complications in patients with SARS-CoV-2 infection: a systematic review
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MUNHOZ, Renato Puppi

; PEDROSO, José Luiz

; NASCIMENTO, Fábio Augusto

; ALMEIDA, Sergio Monteiro de

; BARSOTTINI, Orlando Graziani Povoas

; CARDOSO, Francisco Eduardo C

; TEIVE, Hélio A Ghizoni

Arquivos de Neuro-Psiquiatria

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may 2020, Volume 78 N. 5 Pages 290 - 300

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: À medida que a pandemia da COVID-19 se desenvolve em todo o mundo, diferentes tipos de publicações descreveram suas manifestações neurológicas. Objetivo: Revisar a literatura sobre complicações neurológicas da infecção por SARS-CoV-2. Métodos: A pesquisa bibliográfica foi realizada seguindo diretrizes de revisões sistemáticas, usando palavras-chave específicas baseadas nas complicações neurológicas da COVID-19 descritas até 10 de maio de 2020. Resultados: Foram selecionados 43 artigos, incluindo descrições que variam de sintomas comuns e inespecíficos, como hiposmia e mialgia, a condições mais complexas e com risco de vida, como doenças cerebrovasculares, encefalopatias e síndrome de Guillain-Barré. Conclusão: O reconhecimento das manifestações neurológicas da SARS-CoV-2 deve ser enfatizado apesar dos óbvios desafios enfrentados pelos clínicos que cuidam de pacientes críticos, muitas vezes sedados e apresentando outras complicações sistêmicas concomitantes.

ABSTRACT Background: As the COVID-19 pandemic unfolds worldwide, different forms of reports have described its neurologic manifestations. Objective: To review the literature on neurological complications of SARS-CoV-2 infection. Methods: Literature search performed following systematic reviews guidelines, using specific keywords based on the COVID-19 neurological complications described up to May 10th, 2020. Results: A total of 43 articles were selected, including data ranging from common, non-specific symptoms, such as hyposmia and myalgia, to more complex and life-threatening conditions, such as cerebrovascular diseases, encephalopathies, and Guillain-Barré syndrome. Conclusion: Recognition of neurological manifestations of SARS-CoV-2 should be emphasized despite the obvious challenges faced by clinicians caring for critical patients who are often sedated and presenting other concurrent systemic complications.

https://doi.org/10.1590/0004-282x20200051 11488 downloads

Do as I Do, Not as I Say: Incentivization and the Relationship Between Cognitive Ability and Risk Aversion
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Almeida, Sergio

Revista Brasileira de Economia

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oct 2019, Volume 73 N. 4 Pages 413 - 434

Abstract: En | Text: En | PDF: En

Abstract We study the relationship between cognitive ability and risk aversion under real and hypothetical choice conditions. Our experimental results suggest that the statistical relationship between cognitive ability and risk aversion is sensitive to incentive conditions of the choice problems used to elicit risk preferences. Individuals in the upper tail of the cognitive ability distribution are willing to take more risks. However, this holds only when choices involve hypothetical payoffs. When choices envolve monetary incentives, this correlation is not significant. Results are robust to using alternative measures of cognitive ability.

https://doi.org/10.5935/0034-7140.20190019 373 downloads

Evaluación del efecto de las tensiones térmicas residuales en el pandeo y post-pandeo de placas compuestas con refuerzos laterales
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Sánchez, Martha L de Almeida, Sergio F. M Carrillo, Julián

Revista Latinoamericana de Metalurgia y Materiales

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jun 2017, Volume 37 N. 1 Pages 45 - 59

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

En este artículo se evalúa experimentalmente el efecto de las tensiones térmicas residuales en el pandeo y post-pandeo de placas compuestas reforzadas. El estudio se centra en el análisis de placas cuadradas de carbono-epoxi, en las cuales fueron colocados refuerzos laterales. Para evaluar el efecto de las tensiones que surgen durante el proceso de curado del laminado se utilizaron dos metodologías diferentes en el proceso de pegado de los mismos: en el primer procedimiento los refuerzos fueron pegados a temperatura ambiente (22ºC), mientras que en el segundo procedimiento se curaron en autoclave a 177ºC, provocando un gradiente térmico de 155ºC. Para los ensayos de pandeo y post-pandeo se aplicó una fuerza de compresión y se midieron los desplazamientos transversales originados en la placa con ayuda de una técnica óptica llamada topogrametría. Los resultados experimentales fueron comparados con resultados numéricos obtenidos con el software comercial ABAQUS®. Los valores obtenidos demuestran el efecto de la inducción de tensiones residuales durante el proceso de manufactura de laminados compuestos, en el comportamiento mecánico de los mismos, específicamente en el pandeo y post-pandeo, el cual queda evidenciado en un aumento de la rigidez de las placas, al ser curadas a una temperatura de 177ºC.

The objective of this work is to evaluate experimentally the effects of the thermal residual stresses on the buckling and post-buckling behavior of plates manufactured with reinforced symmetrical laminates. This study presents the analysis of square carbon/epoxy plates reinforced using lateral reinforcements. The reinforcements were bonded using two different procedures. In the first procedure, the reinforcements were bonded at room temperature, whereas in the second procedure they were co-cured with the plate at 177ºC. The buckling and post-buckling tests were performed applying a compression and the transverse displacements caused by the load were also measured using the topogrametry technique. All the experimental results were compared with numerical results using commercial software ABAQUS®. The obtained values demonstrated the influence of the thermal residual stresses on the mechanical behavior of the plate, especially in the buckling and post-buckling behavior, which is evidenced by an increase on stiffness of the composite plates, to be cured at a temperature of 177ºC.

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Custos da ampliação da licença-paternidade no Brasil
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Almeida, Sergio Pereda, Paula Ferreira, Rafael

Revista Brasileira de Estudos de População

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dec 2016, Volume 33 N. 3 Pages 495 - 516

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Há uma crescente literatura empírica documentando que educação e cuidado parental de qualidade estão associados com um melhor desenvolvimento emocional e cognitivo da criança. Diante disso, governos de vários países vêm promovendo mudanças nas suas leis trabalhistas, com o objetivo de dar suporte financeiro e legal (proteção do emprego) para as mães e também os pais com crianças recém-nascidas. O Brasil aprovou recentemente o Marco Legal da Primeira Infância (Lei n. 13.257/2016), que ampliou a licença-paternidade de 5 para 20 dias. Pouco se sabe, entretanto, sobre o impacto econômico desse tipo de política pública. O presente trabalho procura quantificar os custos intertemporais do custo econômico direto da extensão da licença-paternidade para o Brasil. Para isso utilizam-se microdados da Pesquisa Nacional por Amostra de Domicílios, indicadores do mercado de trabalho brasileiro e uma série de projeções populacionais para construir cenários estáticos para estimativas da probabilidade de os pais solicitarem o uso da licença. Os resultados indicam que a extensão da licença-paternidade para 20 dias tem baixo custo – cerca de R$ 100 milhões por ano no cenário mais provável, o que representa 0,01% da arrecadação federal em 2014. Conquanto a magnitude dos benefícios seja ainda desconhecida no Brasil, os resultados sugerem que esse tipo de intervenção será provavelmente custo-efetiva.

Abstract There is a growing empirical literature documenting that quality in early education and parental care are associated with better emotional and cognitive development later in life. With this in mind, governments in several countries have changed labor laws in order to give more employment security for parents of the newborns aiming to give financial and legal support (employment protection). A law recently passed in Brazil has increased paternity leave from 5 to 20 working days of paid leave (Marco da Primeira Infância, Law 13.257/2016). Little is known, however, about the economic impacts of such a law. This paper aims at quantifying the costs of such increase in paternity leave. By utilizing the annual household survey microdata (Pesquisa Nacional por Amostra de Domicílios), some labor market indicators and a population projections series it is calculated fathers’ probability of claiming paternity benefits. Several long-range forecasts about the costs implementation produced. The results indicates that the increase in paid paternity leave, due to this change in the law, has relatively low cost – around 100 million Brazilian reais per year in the most likely scenario, an amount that is 0.01% of federal revenues in 2014. While the benefits of increasing paid paternity leave are still unknown in Brazil, the results suggest that this kind of intervention is likely to be cost-effective.

Resumen Existe una creciente documentación en la literatura empírica sobre la asociación entre la educación de calidad y el cuidado de los padres con un mejor desarrollo emocional y cognitivo de los niños. Por lo tanto, los gobiernos de varios países promueven cambios en sus leyes laborales destinadas al apoyo financiero y legal (protección del empleo) para madres y padres con hijos recién nacidos. Brasil aprobó recientemente el Marco da Primeira Infância (Ley 13.257/2016) que amplió el permiso parental de cinco a veinte días. Sin embargo, poco se sabe sobre el impacto económico de este tipo de política pública. Este artículo pretende cuantificar los costos de la extensión temporal del permiso de paternidad. A partir de datos de la Pesquisa Nacional por Amostra de Domicilios, de indicadores del mercado de trabajo y de las proyecciones de población, se estimó el costo de la extensión del permiso. Los resultados indican que el costo de esta ampliación de la licencia es bajo —cerca de R$ 100 millones por año en el escenario más probable, lo que representa 0,01% de los ingresos federales en 2014—. Aunque la magnitud de los beneficios de este tipo de intervención sea desconocida en Brasil, los resultados muestran que es probable que sea costo-efectiva.

https://doi.org/10.20947/s0102-30982016c0003 4040 downloads

10.

Melhora cognitiva durante tap test em pacientes com hidrocefalia de pressão normal
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Rocha, Samanta Almeida, Sergio M. Pizzanni, Luciana Romero, Bruna Perboni, Talita Krause, Ricardo M. Kowacs, Pedro A. Ramina, Ricardo

Psicologia, Saúde & Doenças

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apr 2016, Volume 17 N. 1 Pages 67 - 73

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A hidrocefalia de pressão normal (HPN) em geral ocorre entre 7ª e 8ª décadas de vida. Composta por uma tríade de sintomas (marcha, urinária e cognição), é uma das causas de demência potencialmente reversíveis, através do tratamento cirúrgico (implante de válvula cerebral). Exames complementares como o tap test em série (exame da punção lombar) podem melhorar o diagnóstico. O objetivo foi estudar o impacto do tap test sobre a cognição de portadores de HPN. 17 participante (sete homens e 10 mulheres), idade entre 76 e 41 anos e escolaridade de 9,1 anos, selecionados de um grupo de 53 sujeitos segundo critérios de Relkin foram avaliados em três etapas envolvendo domínio cognitivo e marcha: antes da punção (pré-tap); Após a primeira punção lombar (pós-tap 1); e no dia seguinte, após a nova punção (pós tap 2). Neste subgrupo análise estatística apontou diferença significativa entre os resultados pré-tap e póstap na prova de dígitos ordem direta (p<0,013), dígitos ordem inversa (p<0,013); fluência de animais (p<0,004) e na primeira etapa do teste de Stroop (p<0,033). Neste grupo os pacientes obtiveram melhora do desempenho em alguns testes de funções executivas, o que parece estar relacionado a melhora na velocidade de processamento mental.

Idiopathic normal pressure hydrocephalus (INPH) is a syndrome characterized by the classic triad of gait disturbance, potentially reversible dementia (progressive mental deterioration) and urinary incontinence. The dementia can involve executive dysfunction, memory failures and bradyphrenia. The criteria for referral for ventriculoperitoneal shunting are still controversial but include the results of a spinal tap, which is performed to simulate the effect of shunting and to analyze the impact of cerebrospinal fluid (CSF) drainage on the patient’s gait. Objective: To evaluate the immediate effect of a spinal tap on the executive functions of patients with a diagnosis of probable INPH. Methods: Seventeen participants (seven men and ten women) aged 76.41+6.24 years (mean+SD) with 9.01+4.40 years (mean+SD) of schooling were selected from a group of 130 individuals tested. The neuropsychological tests of executive functions used were the Stroop test, digit span task, verbal fluency (animals and letters) (FAR) and MMSE. Patients were evaluated in three stages: before the first CSF drainage and after the first and second CSF drainages. Results: Statistical analysis showed significant differences between the pre-spinal tap and post-spinal tap results in the forward (p<0.013) and backward (p<0.037) digit span task, the animal fluency (p<0.004) and the first stage of the Stroop test (p<0.033). Significant differences were not observed in the orientation test (WMS), mental control (WMS) or MMSE. Conclusion: Of the various tests performed, executive function tests most clearly showed changes resulting from CSF drainage in patients with normal pressure hydrocephalus (NPH). The improvement appears to be related to an improvement in mental processing speed.

https://doi.org/10.15309/16psd170110

11.

Effect of Thermal Residual Stresses on Buckling and Post-Buckling Properties of Laminated Composites Perimetrally Reinforced
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Sánchez Cruz, Martha L. Carrillo, Julián Almeida, Sergio F. Muller de

Latin American Journal of Solids and Structures

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mar 2016, Volume 13 N. 3 Pages 435 - 455

Abstract: En | Text: En | PDF: En

Abstract Several mechanical properties can be affected by the occurrence of residual stresses due to curing, and their effects are more pronounced in laminated composites. The effect of the thermal residual stresses on the buckling and post-buckling properties of perimetrally reinforced laminated composites is experimentally characterized. Carbon/epoxy laminates were prepared using two different techniques. One group of laminates was prepared by co-curing the reinforcement at 177 °C. The second group of laminates was prepared by secondary bonding of the reinforcement to the laminate at room temperature (22°C). Topogrammetry equipment was utilized in order to determine the buckling and post-buckling properties of these two groups of laminates. A numerical model was achieved using commercial software for comparison with the experimental results. Suitable accuracy was observed when comparing experimental and numerical results. The co-cured laminates developed considerably higher critical load for buckling values than those obtained for laminates produced with secondary bonding at room temperature. The experimental and numerical results of this study demonstrate the importance of curing-induced thermal residual stresses on the mechanical behavior of laminate composites.

https://doi.org/10.1590/1679-78251828 1912 downloads

12.

CHARACTERIZATION OF GLUED LAMINATED PANELS PRODUCED WITH STRIPS OF BAMBOO (Guadua magna) NATIVE FROM THE BRAZILIAN CERRADO
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Teixeira, Divino Eterno Bastos, Rodrigo Pinheiro Almeida, Sergio Alberto de Oliveira

CERNE

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dec 2015, Volume 21 N. 4 Pages 595 - 600

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Painéis foram produzidos com taliscas de bambu (Guadua magna) montados em três ou cinco camadas cruzadas entre si em ângulo de 90° e coladas com resina à base de fenol-formaldeído ou PVA. Os painéis foram testados e as propriedades físicas e mecânicas determinadas. Os testes foram quanto aos adesivos comerciais usados, bem como a quantidade de camadas dos painéis. A densidade variou entre 0,690 e 0,768 g.cm-3. Painéis colados com resina PVA mostraram baixa resistência mecânica, apresentando MOR entre 6,7 e 7,8 MPa. Os colados com resina fenol-formaldeído foram mais resistentes, com módulo de ruptura (MOR) entre 55,5 e 87,0 MPa, excelente para painéis similares à base de madeira. Painéis com resina fenólica apresentaram também reduzido inchamento em espessura, até 8,4%. Os painéis produzidos em três camadas apresentaram resistência maior à flexão que os com cinco camadas.

ABSTRACT Panels were produced with strips of bamboo (Guadua magna) in layers crossed at angles of 90° and bonded with phenol-formaldehyde or PVA based resin, glued in three and five plies. The panels were tested and the physical and mechanical properties determined. The tests were primarily related to the commercial adhesives used as well as the number of layers of bamboo used. The density ranged from 0.690 to 0.768 g.cm-3. Panels bonded with PVA resin showed low mechanical strength, with MOR between 6.7 and 7.8 MPa. Those bonded with phenol-formaldehyde adhesive showed high strength, with modulus of rupture (MOR) ranging from 55.5 to 87.0 MPa, which is excellent for boards similar to wood-based panels. Panels with phenolic resin also had reduced thickness swelling, up to 8.4%. The panels made with three layers showed higher resistance to bending than those made with five layers.

https://doi.org/10.1590/01047760201521041893 1731 downloads

13.

Assessment of subjective well-being and quality of life in patients with intestinal stoma
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Salomé, Geraldo Magela Almeida, Sergio Aguinaldo de Mendes, Bruno Carvalho, Maiume Roana Ferreira de Massahud Junior, Marcelo Renato

Journal of Coloproctology (Rio de Janeiro)

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sep 2015, Volume 35 N. 3 Pages 168 - 174

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMOObjetivo:Avaliar o bem-estar subjetivo e qualidade de vida nos pacientes com estoma intestinal.Método:Este estudo foi realizado no Polo dos Estomizados de Pouso Alegre. Os dados foram coletados no período compreendido entre dezembro de 2012 e maio de 2013, após aprovação pelo Comitê de Ética em Pesquisa da Universidade do Vale do Sapucaí sob parecer n◦ 23.277. A amostra foi selecionada de forma não probabilística, por conveniência. Foram utilizados sequentes instrumentos: questionário sobre os dados demográﬁcos e sobre o estoma; Escala de Bem-estar subjetivo e a Escala de Qualidade de Resultados.Resultados:Com relação à Escala de Qualidade de Vida de Flanagan, alcançou-se entre 16 a 22 pontos, revelando que esses pacientes apresentavam alteração na qualidade de vida. Com relação à escala de bem-estar subjetivo nos três domínios: afeto positivo-43 (61,40%) indivíduos; afeto negativo-31 (44,30%) indivíduos e satisfação com a vida 54 (77,10%), todos os indivíduos obtiveram pontuação 3, caracterizando alteração negativa nesses domínios. A média da Escala de Qualidade de Vida de Flanagan foi 26,16, e as médias dos domínios da Escala de Bem-estar subjetivo foram; Afeto positivo: 2,51; Afeto negativo: 2,23 e satisfação com a vida: 2,77, conﬁgurando que esses indivíduos com estoma intestinal que participaram do estudo apresentaram sentimentos negativos relacionados à própria autoestima e à queda na qualidade de vida.Conclusão:Os pacientes com estoma intestinal que participaram deste estudo apresentaram alteração na qualidade de vida e no bem-estar subjetivo.

ABSTRACTObjective:To investigate the subjective well-being and quality of life in patients with intestinal stoma.Method:This study was conducted at Ostomized People's Pole of Pouso Alegre. Data were collected in the period between December 2012 and May 2013, after approval by the Ethics Committee of the Universidade do Vale do Sapucaí under opinion No. 23,277. The participants were selected by a convenience non-probability sampling. The following instruments were used: a questionnaire on demographics and stoma; a Subjective Well-being Scale; and a Quality Outcome Scale.Results:Regarding the Flanagan Quality of Life Scale, 16-22 points were obtained, indicating that these patients suffered changes in their quality of life. Regarding the scale of subjective well-being in three domains: positive affect - 43 (61.40%) individuals; negative affect - 31 (44.30%) individuals; and life satisfaction - 54 (77.10%), all subjects obtained a score of 3, characterizing a negative change in these domains. The mean Flanagan Quality of Life Scale score was 26.16, and the means for the domains included in the Subjective Well-being Scale were: positive affect: 2.51; negative affect: 2.23 and life satisfaction: 2.77, indicating that the intestinal stoma users who participated in the study had negative feelings related to their own self-esteem and to the loss of quality of life.Conclusion:Patients with intestinal stoma who participated in this study had a change in their quality of life and in subjective well-being.

https://doi.org/10.1016/j.jcol.2015.03.002 2429 downloads

14.

Quality of life and self-esteem of patients with intestinal stoma
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Salomé, Geraldo Magela Almeida, Sergio Aguinaldo de Silveira, Maiko Moura

Journal of Coloproctology (Rio de Janeiro)

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dec 2014, Volume 34 N. 4 Pages 231 - 239

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O objetivo deste estudo foi investigar a qualidade de vida e a autoestima em pacientes com estoma intestinal. Trata-se de um estudo clínico, primário, descritivo e analítico. Este estudo foi realizado no Pólo dos ostomizados de Pouso Alegre, após aprovação pelo Comitê de Ética em Pesquisa da Faculdade de Ciências da Saúde “Dr. José Antônio Garcia Coutinho", sob o parecer no 23.277. Foram utilizados três instrumentos para a coleta de dados da pesquisa: questionário sobre os dados demográficos e estoma, Escala de Autoestima de Rosenberg/UNIFESP-EPM e Escala de Qualidade de Vida de Flanagan. Foram utilizados para a análise estatística os seguintes testes: Qui-quadrado e Kruskal-Wallis e correlação de Spearman. Para todos os testes estatísticos, foi considerado o nível de significância de 5% (p < 0,05). A maioria dos participantes tinha mais de 60 anos, eram do gênero masculino e partici-pavam de grupo de apoio. Vinte e um (30%) dos participantes da pesquisa eram analfabetos. Neoplasia foi a causa mais frequente para a aquisição da ostomia; o tipo de ostomia foi colostomia permanente. Os indivíduos não foram submetidos à demarcação do estoma e nem realizaram irrigação. Com relação ao tipo de complicação, 34 (48,60%) apresentavam dermatite; 14 (20%) retração. A média da Escala de Autoestima de Rosenberg/UNIFESP-EPM foi 10,81 e a média da Escala de Qualidade de Vida de Flanagan (EQVF) foi 26,16. Concluiu-se que os indivíduos com estoma intestinal que participaram da pesquisa apresentavam autoestima e qualidade de vida prejudicadas.

The aim of this study was to investigate the quality of life and self-esteem in patients with intestinal stoma. This is a clinical, primary, descriptive, analytical study, conducted at the Ostomized People's Pole of Pouso Alegre, after approval by the Ethics Committee of the Faculdade de Ciências da Saúde Dr. Jose Antonio Garcia Coutinho under opinion No. 23,227. Three instruments - a questionnaire on demographics and stoma, Rosenberg Self-Esteem Scale/UNIFESP-EPM and Flanagan Quality of Life Scale - were used in the data collection. The following tests were used for statistical analysis: chi-squared and Kruskal-Wallis tests and Spearman correlation. For all statistical tests, the level of significance of 5% (p<0.05) was considered. Most participants were older than 60 years, of male gender and attended support groups. Twenty-one (30%) of respondents were illiterate. Neoplasia was the most frequent of the causes that led patients to receive an ostomy; permanent colostomy was the type of ostomy used. Individuals were not submitted to stoma demarcation and did not make irrigation. Regarding the type of complication, 34 (48.60%) had dermatitis; 14 (20%) showed retraction.The mean of Rosenberg Self-Esteem Scale/UNIFESP-EPM was 10.81 and the mean of Flanagan Quality of Life Scale was 26.16. It was concluded that individuals with intestinal stoma participating in the survey showed impaired self-esteem/quality of life.

https://doi.org/10.1016/j.jcol.2014.05.009 6450 downloads

15.

Association of sociodemographic and clinical factors with the self-image and self-esteem of individuals with intestinal stoma
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Salomé, Geraldo Magela Almeida, Sergio Aguinaldo de

Journal of Coloproctology (Rio de Janeiro)

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sep 2014, Volume 34 N. 3 Pages 159 - 166

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Objetivo: Avaliar os fatores sociodemográficos e clínicos e correlacioná-los à autoimagem e autoestima. Métodos: Estudo realizado no Polo dos Estomizados de Pouso Alegre. Os dados foram coletados entre dezembro de 2012 e maio de 2013. A amostra foi por não probabilística, por conveniência. Para coleta de dados, foram utilizadas a Escala de Autoestima Rosenberg/UNIFESP-EPM e a escala BodyInvestmentScale. Para análise estatística, foram utilizados os testes do Qui-quadrado e de Kruskal-Wallise a correlação de Spearman. Foram considerados os níveis de significância 5% (p ≤ 0,05). Resultados: Os participantes apresentaram a média de 10,81 na Escala de Autoestima Rosenberg/UNIFESP-EPM. Com relaação à escala BodyInvestmentScale, a média do escore total foi 38,79; a médianos domínios imagem corporal foi de 7,74 e no toque pessoal, 21,31. Ao comparamos os dados relacionados ao estoma e sociodemográficos com a Escala de Autoestima Rosenberg/UNIFESP-EPM e com escala BodyInvestmentScale, percebemos que todos os pacientes apresentaram queda na autoestima e na autoimagem. Os indivíduos estavam na faixa etária acima de 60 anos, sexo masculino, eram aposentados e casados e não participavam de grupo de apoio/associação. Com relação às características do estoma, os indivíduos com colostomia permanente tinham como causas da realização do estoma doença inflamatória e neoplasia; os estomas mensuravam entre 20 a 40 mm; eles utilizavam dispositivo com duas peças. Pessoas que não foram comunicadas de que iriam ser submetidas ao estoma, e em que não foi realizada a demarcação apresentaram piora na autoestima e na autoimagem com relação às outras características relacionadas à lesão e às sociodemográficas. Conclusão: Pacientes que participaram deste estudo apresentaram baixa na autoimagem e autoestima em todas as características do estoma e nos dados sociodemográficos, significando que esses indivíduos tinham sentimentos negativos em relação ao próprio corpo.

Objective: To evaluate the clinical and sociodemographic factors and correlate them to the self-image and self-esteem. Methods: A study conducted at Ostomy Pole of PousoAlegre. The data were collected between December 2012 and May 2013. This was a non-probabilistic, by convenience, sample. For data collection, the Rosenberg Self-Esteem Scale/UNIFESP-EPM and Body Investment Scale were used. For statistical analysis, chi-squared test, Kruskal-Wallis test and Spearman correlation were used. Levels of significance of 5% (p ≤ 0.05) were considered. Results: Participants had a mean score of 10.81 in the Rosenberg Self-Esteem Scale/UNIFESP. Regarding Body Investment Scale results, the mean total score was 38.79; the mean in the domain of body image was 7.74, and for personal touch, 21.31. When comparing data related to the stoma and sociodemographic profiles with the Rosenberg Self-Esteem Scale/UNIFESP and Body Investment Scale, we realize that all patients demonstrated a decrease in self-esteem and self-image. Individuals were over 60 years old, male, retired, married and were not participants in support group/association. With regard to the characteristics of the stoma, those permanent colostomized had as causes of stoma implementation inflammatory disease and neoplasia; stomata measured between 20 and 40 mm; these people used two-piece devices. People who have not been notified that would be subjected to the stoma and in whom no demarcation was done showed worsening in self-esteem and self-image in relation to other features related to injury and sociodemographic data. Conclusion: Patients who participated in this study had low self-image and self-esteem in all characteristics of the stoma and in sociodemographic data, meaning that these individuals had negative feelings about their own bodies.

https://doi.org/10.1016/j.jcol.2014.05.005 2615 downloads

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