ABSTRACT Introduction: We aim to compare the safety and effectiveness of the KangDuo (KD)-Surgical Robot-01 (KD-SR-01) system and the da Vinci (DV) system for robot-assisted radical nephroureterectomy (RARNU). Materials and Methods: This multicenter prospective randomized controlled trial was conducted between March 2022 and September 2023. Group 1 included 29 patients undergoing KD-RARNU. Group 2 included 29 patients undergoing DV-RARNU. Patient demographic and clinical characteristics, perioperative data, and follow-up outcomes were collected prospectively and compared between the two groups. Results: There were no significant differences in patient baseline demographic and preoperative characteristics between the two groups. The success rates in both groups were 100% without conversion to open or laparoscopic surgery or positive surgical margins. No significant difference was observed in docking time [242 (120-951) s vs 253 (62-498) s, P = 0.780], console time [137 (55-290) min vs 105 (62-220) min, P = 0.114], operative time [207 (121-460) min vs 185 (96-305) min, P = 0.091], EBL [50 (10-600) mL vs 50 (10-700) mL, P = 0.507], National Aeronautics and Space Administration Task Load Index scores, and postoperative serum creatinine levels between the two groups. None of the patients showed evidence of distant metastasis, local recurrence, or equipment-related adverse events during the four-week follow-up. One (3.4%) patient in Group 2 experienced postoperative enterovaginal and enterovesical fistulas (Clavien-Dindo grade III). Conclusions: The KD-SR-01 system is safe and effective for RARNU compared to the DV Si or Xi system. Further randomized controlled studies with larger sample sizes and longer durations are required. Introduction KDSurgical KD Surgical Robot01 Robot 01 Robot-0 KDSR01 KDSR SR (KD-SR-01 (DV robotassisted robot assisted RARNU. . (RARNU) Methods 202 2023 KDRARNU. KDRARNU KD-RARNU DVRARNU. DVRARNU DV-RARNU data followup follow up Results 100 margins 242 [24 120951 120 951 (120-951 25 62498 62 498 (62-498 0.780, 0780 0.780 , 0 780 0.780] 137 [13 55290 55 290 (55-290 10 62220 220 (62-220 0.114, 0114 0.114 114 0.114] 207 [20 121460 121 460 (121-460 18 96305 96 305 (96-305 0.091, 0091 0.091 091 0.091] [5 10600 600 (10-600 5 10700 700 (10-700 0.507, 0507 0.507 507 0.507] scores metastasis recurrence equipmentrelated equipment related fourweek four week followup. up. 3.4% 34 3 4 (3.4% ClavienDindo Clavien Dindo III. III III) Conclusions KD-SR-0 required Robot0 Robot- KDSR0 (KD-SR-0 (RARNU 20 24 [2 12095 12 95 (120-95 6249 6 49 (62-49 078 0.78 78 13 [1 5529 (55-29 6222 22 (62-22 011 0.11 11 12146 46 (121-46 9630 9 30 (96-30 009 0.09 09 [ 1060 60 (10-60 1070 70 (10-70 050 0.50 3.4 (3.4 KD-SR- (KD-SR- 1209 (120-9 624 (62-4 07 0.7 7 552 (55-2 622 (62-2 0.1 1214 (121-4 963 (96-3 00 0.0 106 (10-6 107 (10-7 05 0.5 3. (3. KD-SR (KD-SR (120- (62- 0. (55- (121- (96- (10- (3 (120 (62 (55 (121 (96 (10 ( (12 (6 (5 (9 (1

Abstract In urban combat, sub-millimeter inert metal powder is used to replace fragments in explosive bombs, which can effectively reduce collateral damage. In order to investigate the damage effect of high-speed metal particles on the human body, a particle ring filled with a charge was designed to create an explosion-driven particle cloud for the penetration ballistic gelatin. The particle ring was made of polytetrafluoroethylene (PTFE) and sub-millimeter tungsten powder. The dispersion properties of the particle cloud driven by the explosion were studied with high-speed photography and ballistic gelatin. Furthermore, the numerical simulation models of particle-penetrating gelatin based on the experimental results were established with the finite element method. The influences of the particle size and velocity on the penetration depth and cavity diameter was obtained. The relationship between the critical interference distance of the cavity and the distance between particles was determined. This paper provides references and theoretical support for the design of low collateral damage ammunition based on inert metal powder. combat submillimeter sub millimeter bombs highspeed high speed body explosiondriven PTFE (PTFE Furthermore particlepenetrating penetrating method obtained determined

Abstract Background: Patients with Hematological Malignancies (HM) are at a high risk of mortality from Coronavirus disease 2019 (COVID-19). The available antivirals were different between China and other countries. In China, azvu-dine was obtained for emergency use to treat adult COVID-19 patients with moderate symptoms in July 2022. While nirmatrelvir-ritonavir was well-known and used in many countries. The purpose of the present study was to assess whether there was any difference in the efficacy and safety of the two drugs. Methods: This study was a prospective observational study of patients with HM who developed COVID-19. Patients were divided into three treatment groups: nirmatrelvir-ritonavir, azvudine, and observation. Treatment outcomes, first nucleic acid test negative time, hospitalization time, and the conversion rate of mild or moderate disease to severe disease were recorded. Results: First nucleic acid test negative time (23.5 days vs. 34 days, p = 0.015), hospitalization time (p = 0.015), and conversion rate (31.8 % vs. 8 %, p = 0.046) were statistically different between the nirmatrelvir-ritonavir and observation groups. First nucleic acid test negative time (20 days vs. 34 days, p = 0.009) and hospitalization time (p = 0.026) were statistically different between the azvudine and observation groups. ECOG score and liver disease were significantly associated with the conversion rate from mild or moderate disease to severe disease using multivariate analysis (p < 0.05). Conclusions: The authors found no significant differences existed in outcome measures between patients with HM and COVID-19 who were treated with nirmatrelvir-ritonavir or azvudine. Background (HM 201 COVID19. COVID19 COVID 19 . (COVID-19) countries azvu dine COVID-1 2022 nirmatrelvirritonavir nirmatrelvir ritonavir wellknown well known drugs Methods 19. groups nirmatrelvirritonavir, ritonavir, outcomes recorded Results 23.5 235 23 5 (23. vs 3 0.015, 0015 0.015 , 0 015 0.015) 31.8 318 31 (31. 0.046 0046 046 20 (2 0.009 0009 009 0.026 0026 026 0.05. 005 0.05 05 0.05) Conclusions COVID1 1 (COVID-19 COVID- 202 23. 2 (23 001 0.01 01 31. (31 0.04 004 04 ( 0.00 000 00 0.02 002 02 0.0 (COVID-1 (3 0. (COVID- (COVID

SUMMARY: At present, the anatomical relationship the mid-portion of popliteus tendon complex (PTC) and the surrounding tissues is still unclear, especially its relationship to the posterior cruciate ligament (PCL). It affected the anatomical reconstruction of the posterolateral complex (PLC) injury. A total of 30 cases of the adult human knee joint fixed with formalin were used. Sagittal sections were made in 14 knee joints by the P45 plastination technique and dissection of 16 cases of knee joints. The P45 section revealed that the popliteus muscle fascia ran superiorly over the posterior edge of the tibial intercondylar eminence, and turned forward to be integrated into the PCL. Laterally, near the posterior edge of the lateral tibial plateau, the popliteus tendon penetrates through the articular capsule (AC), where two dense fibrous bundles were given off upwards by the popliteus tendon: one was the ventral fiber bundle, which ran superiorly over the posterior edge of the tibial plateau and then moved forwards to connect with the lateral meniscus; the dorsal fibers bundle ascended directly and participated in the AC. Meanwhile, the popliteus muscle dissection showed that at the posterior edge of the platform of the lateral condyle of the tibia, at the tendon-muscle transition, the PTC and AC were anchored to PCL.

RESUMEN: En la actualidad, la relación anatómica entre la porción media del complejo tendinoso poplíteo (CTP) y los tejidos circundantes aún no está clara, especialmente su relación con el ligamento cruzado posterior (LCP). Esto afecta la reconstrucción anatómica de la lesión del complejo posterolateral (LCP). Se utilizaron un total de 30 casos de articulaciones de rodillas humanas de individuos adultos fijadas con formalina. Se realizaron cortes sagitales en 14 articulaciones de rodilla mediante la técnica de plastinación P45 y disección de 16 casos de articulaciones de rodilla. La sección P45 reveló que la fascia del músculo poplíteo discurría superiormente sobre el margen posterior de la eminencia intercondílea tibial y giraba hacia delante para integrarse en el LCP. Lateralmente, cerca del margen posterior de la platillo tibial lateral, el tendón poplíteo penetra a través de la cápsula articular (CA), donde el tendón poplíteo desprendió hacia arriba dos haces fibrosos densos: uno era el haz de fibras ventral, que corría superiormente sobre el margen posterior de la meseta tibial y luego se movió hacia adelante para conectar con el menisco lateral; el haz de fibras dorsales ascendía directamente y participaba en la CA. Por su parte, la disección del músculo poplíteo mostró que en el margen posterior del platillo del cóndilo lateral de la tibia, en la transición tendón-músculo, el CTP y el AC estaban anclados al LCP.

RESUMO Introdução: O treinamento de força do core concentra-se principalmente no grupo muscular e no sistema neuromuscular da área central do corpo humano, com o propósito de ganho de força e estabilidade para movimentos complexos. Estudos relatam o efeito do treinamento do core em atletas de alta capacidade, porém ainda há uma lacuna quanto aos impactos sobre a capacidade física em atletas de corrida. Objetivo: Estudar os efeitos resultantes do treinamento de força no core dos atletas e os impactos diretos na qualidade da corrida. Métodos: Os atletas da equipe masculina de corrida, no centro de treinamento de atletismo do Instituto de Educação Física, foram treinados com força fundamental por 10 a 12 semanas. Após o período, testes físicos, segundo protocolos pré-determinados, foram executados. Os dados foram comparados antes e após a intervenção, após o tratamento estatístico, os achados foram discutidos segundo a literatura cientifica. Resultados: Após 12 semanas de treinamento, entre as cinco habilidades esportivas, houve apenas diferença significativa antes e depois do treinamento de flexão lateral corporal (lado direito) (P<0,05), e não houve diferença significativa antes e depois do treinamento das outras quatro habilidades esportivas (P > 0,05). Conclusão: Através dos exercícios estáticos e dinâmicos do treinamento de força do core, podemos melhorar efetivamente a intervenção da propriocepção no movimento corporal, para que os corredores possam controlar com mais precisão as articulações e músculos, garantindo a precisão do movimento e postural. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.

ABSTRACT Introduction: Core strength training focuses mainly on the muscle group and neuromuscular system of the central area of the human body to gain strength and stability for complex movements. Studies have reported the effect of core training on high-capacity athletes, but there is still a gap regarding the impacts on physical capacity in running athletes. Objective: To study the effects of strength training on athletes’ core and the direct impacts on running quality. Methods: Athletes of the men’s running team at the athletic training center of the Institute of Physical Education were core strength trained for 10 to 12 weeks. After the period, physical tests, according to predetermined protocols. The data were compared before, after the intervention, and after statistical treatment, and the findings were discussed according to the scientific literature. Results: After 12 weeks of training, among the five sports skills, there was only a significant difference before and after training of body lateral flexion (right side) (P<0.05), and there was no significant difference before and after training of the other four sport skills (P > 0.05). Conclusions: Through the static and dynamic exercises of core strength training, we can effectively improve the proprioception intervention in body movement so that runners can more accurately control their joints and muscles, ensuring movement and postural accuracy. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.

RESUMEN Introducción: El entrenamiento de la fuerza del core se concentra principalmente en el grupo muscular y en el sistema neuromuscular de la zona central del cuerpo humano, con el fin de ganar fuerza y estabilidad para los movimientos complejos. Los estudios han informado sobre el efecto del entrenamiento del tronco en los atletas de alta capacidad, pero todavía hay un vacío en cuanto a los impactos en la capacidad física en los atletas que corren. Objetivo: Estudiar los efectos resultantes del entrenamiento de fuerza en el core de los atletas y los impactos directos en la calidad de la carrera. Métodos: Los atletas del equipo masculino de atletismo, en el centro de entrenamiento de atletismo del Instituto de Educación Física, fueron entrenados con fuerza central durante 10 a 12 semanas. Tras el periodo, se ejecutaron pruebas físicas, según protocolos predeterminados. Los datos se compararon antes y después de la intervención, tras el tratamiento estadístico, los resultados se discutieron de acuerdo con la literatura científica. Resultados: Después de 12 semanas de entrenamiento, entre las cinco habilidades deportivas, sólo hubo diferencia significativa antes y después del entrenamiento de la flexión lateral del cuerpo (lado derecho) (P<0,05), y no hubo diferencia significativa antes y después del entrenamiento de las otras cuatro habilidades deportivas (P > 0,05). Conclusiones: A través de ejercicios estáticos y dinámicos de entrenamiento de la fuerza del core, podemos mejorar eficazmente la intervención de la propiocepción en el movimiento del cuerpo, de modo que los corredores puedan controlar con mayor precisión las articulaciones y los músculos, asegurando la precisión del movimiento y la postura. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.

Abstract Background: The accuracy of diagnosis and the safety of treatment in colonoscopy depends largely on the quality of bowel cleansing. This study aimed to compare the efficacy and adverse reactions of Polyethylene Glycol (PEG) combined with lactulose with that of PEG alone in bowel preparation before colonoscopy. Methods: The authors searched a number of databases including EMBASE, MEDLINE, Cochrane Library, and China Academic Journals Full-text Database. The authors screened according to literature inclusion and exclusion criteria, assessed the quality of the included literature, and extracted the data. The meta-analysis of included literature used RevMan 5.3 and Stata 14.0 software. Results: A total of 18 studies, including 2274 patients, were enrolled. The meta-analysis showed that PEG combined with lactulose had a better efficacy (OR = 3.87, 95% CI 3.07‒4.87, p = 0.000, and I2 = 36.2% in the efficiency group; WMD = 0.86, 95% CI 0.69‒1.03, p = 0.032 and I2 = 0% in the BBPS score group) in bowel preparation for patients with or without constipation. Moreover, PEG combined with lactulose had fewer adverse reactions, including abdominal pain (OR = 1.42, 95% CI 0.94‒2.14, p = 0.094), nausea (OR = 1.60, 95% CI 1.13‒2.28, p = 0.009) and vomiting (OR = 1.77, 95% CI 1.14‒2.74, p = 0.011), than PEG alone. No significant reduction in the incidence of abdominal distention was observed. Conclusion: PEG combined with lactulose may be a better choice for bowel preparation before colonoscopy compared with PEG alone. Background cleansing (PEG Methods EMBASE MEDLINE Library Fulltext Full text Database criteria data metaanalysis meta analysis 53 5 3 5. 140 14 0 14. software Results 1 studies 227 enrolled OR 387 87 3.87 95 307487 07 4 3.07‒4.87 0000 000 0.000 I 362 36 2 36.2 group 086 86 0.86 069103 69 03 0.69‒1.03 0032 032 0.03 constipation Moreover 142 42 1.42 094214 94 0.94‒2.14 0.094, 0094 0.094 , 094 0.094) 160 60 1.60 113228 13 28 1.13‒2.28 0.009 0009 009 177 77 1.77 114274 74 1.14‒2.74 0.011, 0011 0.011 011 0.011) observed Conclusion 22 38 8 3.8 9 30748 3.07‒4.8 00 0.00 36. 08 0.8 06910 6 0.69‒1.0 003 0.0 1.4 09421 0.94‒2.1 0.09 09 16 1.6 11322 1.13‒2.2 17 7 1.7 11427 1.14‒2.7 001 0.01 01 3. 3074 3.07‒4. 0. 0691 0.69‒1. 1. 0942 0.94‒2. 1132 1.13‒2. 1142 1.14‒2. 307 3.07‒4 069 0.69‒1 0.94‒2 113 1.13‒2 114 1.14‒2 30 3.07‒ 06 0.69‒ 0.94‒ 11 1.13‒ 1.14‒ 3.07 0.69 0.94 1.13 1.14 3.0 0.6 0.9 1.1

Abstract Fruits will be subjected inevitably to various external forces in the process of harvesting, transportation, processing, and storage, which will cause mechanical damage. The research on mechanical properties and damage mechanisms of fruit can effectively control its loss. In this study, fruits are divided into different types according to their morphology and structure. The impact, vibration, static pressure, and other mechanical damage on fruits are studied. It is important to identify the damaged parts of fruit after damage quickly and accurately. Therefore, this study analyzes the application of nondestructive testing technologies such as spectral detection technology, NMR (nuclear magnetic resonance) detection technology, and acoustic and electrical characteristics detection technology in fruit damage detection. harvesting transportation processing storage loss structure impact vibration pressure studied accurately Therefore nuclear resonance

Pilot trials have suggested that repetitive transcranial magnetic stimulation (rTMS) may reduce limb spasticity in multiple sclerosis (MS). We carried out the current meta-analysis to synthesize currently available evidence regarding such correlation. Up to November 2022, five international electronic databases (Cochrane CENTRAL, PubMed, Embase, Web of Science, and CINAHL) and four Chinese electronic databases (CBM, CNKI, WanFang Data, and VIP) were systematically searched to identify randomized trials comparing active rTMS and sham stimulation in patients with MS-related spasticity. Two reviewers independently selected studies and extracted data on study design, quality, clinical outcomes, and time points measured. The primary outcome was clinical spasticity relief after intervention. Secondary outcomes included spasticity at the follow-up visit 2 weeks later and post-treatment fatigue. Of 831 titles found, we included 8 studies (181 participants) in the quantitative analysis. Pooled analyses showed that rTMS therapy was associated with significant spasticity relief in the early post-intervention period [standardized mean differences (SMD): -0.67; 95%CI: -1.12 to -0.21], but there was insufficient evidence for rTMS in reducing spasticity at the follow-up visit 2 weeks later (SMD: -0.17; 95%CI: -0.52 to 0.17) and fatigue (SMD: -0.26; 95%CI: -0.84 to 0.31). This evidence supports the recommendations to treat MS-related spasticity with rTMS, but underlines the need for further large randomized trials. (rTMS MS. MS . (MS) metaanalysis meta analysis correlation 2022 Cochrane CENTRAL PubMed Embase Science CINAHL CBM, CBM (CBM CNKI Data VIP MSrelated related design quality measured intervention followup follow up posttreatment post treatment 83 found 181 (18 participants postintervention standardized SMD (SMD) 0.67 067 0 67 -0.67 95%CI 95CI CI 95 1.12 112 1 12 -1.1 0.21, 021 0.21 , 21 -0.21] (SMD 0.17 017 17 -0.17 0.52 052 52 -0.5 0.26 026 26 -0.26 0.84 084 84 -0.8 0.31. 031 0.31 31 0.31) (MS 202 18 (1 0.6 06 6 -0.6 9 1.1 11 -1. 02 0.2 -0.21 0.1 01 -0.1 0.5 05 5 -0. -0.2 0.8 08 03 0.3 3 20 ( 0. 1. -1 -0 -

Abstract The fruit softening seriously affected the quality of Annona squamosa, and the edible coating combined with exogenous calcium had a positive effect on inhibiting the softening of A. squamosa. In this paper, the rheological properties of C-AeP-P solution and the effect of Ca2+ on the rheological properties of the solution were studied. Based on this, the indicators of fruit hardness, freshness and plumpness were used to monitor the softening effect of A. squamosa. The results show that: C-AeP-P solution showed non-Newtonian shear-thinning behavior over the range of 0.2-1.0%. With the increase of C-AeP-P concentration, the apparent viscosity and solids like properties increased. After the addition of Ca2+, C-AeP-P had apparent differences on apparent viscosity. The G′ and G″ of C-AeP-P were increased with increasing oscillation frequency. C-AeP-P and C-AeP-P+Ca2+ treatment can slow down rapidly decline of fruit hardness, increase of soluble solid content, loss of water, change peel color and regulate the expression of key enzyme genes AI and Ni. It was concluded that the coating treatment of C-AeP-P alleviates the adverse effects of quality changes during storage, so as to improve the quality and prolong the shelf life of A. squamosa. squamosa A paper CAePP C AeP P Ca2 Ca studied hardness nonNewtonian non Newtonian shearthinning shear thinning 0.21.0%. 0210 0.2 1.0%. 0 2 1 0.2-1.0% concentration G frequency CAePP+Ca2+ CAePPCa2 CAePPCa P+Ca2+ C-AeP-P+Ca2 content water Ni storage 21 0.21.0% 021 02 0. 10 1.0% 0.2-1.0 CAePP+Ca2 PCa2 PCa P+Ca2 C-AeP-P+Ca 0.21.0 1.0 0.2-1. CAePP+Ca P+Ca 0.21. 1. 0.2-1 0.21 0.2-

SUMMARY: For treating cruciate ligament injuries, especially for characterizing the mechanics of the tunnel in cruciate ligament reconstruction, correctly understanding the bony information of the attachment area of the cruciate ligaments is significant. We studied 31 knee joints of middle-aged Chinese adults using the P45 sheet plastination technique, focusing on the attachment areas of the cruciate ligaments, especially the bony structures. The trabeculae at the attachment area were distributed radially and extended deep into the medial wall of the lateral condyle of the femur. However, in the anterior part of the intercondylar eminence, the trabeculae of the anterior group were parallelly arranged along the tendinous fibers of the anterior cruciate ligament, while the trabeculae of the posterior group were parallelly arranged along the perpendicular direction of the anterior cruciate ligament fibers. Similarly, at the attachment area of the lateral wall of the medial condyle of the posterior cruciate ligament, the trabeculae extended radially toward the deep medial condyle. Deep in the posterior part of the intercondylar eminence, the trabeculae were arranged longitudinally. In the anterior part of the intercondylar eminence, the trabeculae were parallelly arranged along the perpendicular directions of ligament fibers. The distribution patterns of the trabecular at the attachment areas of the cruciate ligaments at the ends of the femur and tibia were different. This difference should be considered when orthopedic surgeons reconstruct anterior cruciate ligaments.

RESUMEN: Para el tratamiento de lesiones de los ligamentos cruzados, especialmente para caracterizar la mecánica del túnel en su reconstrucción, es importante comprender correctamente la información ósea del área de inserción de estos ligamentos. Estudiamos 31 articulaciones de rodilla de individuos chinos, adultos, de mediana edad, utilizando la técnica de plastinación de láminas P45, centrándonos en las áreas de unión de los ligamentos cruzados, especialmente en las estructuras óseas. Las trabéculas en el área de inserción se distribuyeron radialmente y se extendieron profundamente en la pared medial del cóndilo lateral del fémur. Sin embargo, en la parte anterior de la eminencia intercondílea, las trabéculas del grupo anterior estaban dispuestas paralelamente a lo largo de las fibras tendinosas del ligamento cruzado anterior, mientras que las trabéculas del grupo posterior estaban dispuestas paralelamente a lo largo de la dirección perpendicular de las fibras del ligamento cruzado anterior. De manera similar, en el área de inserción en la cara lateral del cóndilo medial del ligamento cruzado posterior, las trabéculas se extendían radialmente y profundas hacia el cóndilo medial. Profundamente en la parte posterior de la eminencia intercondílea, las trabéculas estaban dispuestas longitudinalmente. En la parte anterior de la eminencia intercondílea, las trabéculas estaban dispuestas paralelamente a lo largo de las direcciones perpendiculares de las fibras del ligamento. Los patrones de distribución del tejido óseo trabecular en las áreas de unión de los ligamentos cruzados en los extremos del fémur y la tibia eran diferentes. Estas diferencias deben tenerse en consideración cuando los cirujanos ortopédicos reconstruyen los ligamentos cruzados anteriores.

Abstract The present study was aimed to investigate the clinical significance of methyl-CpG binding protein 2 (MECP2) in patients with postherpetic neuralgia (PHN). This prospective case control study enrolled 319 cases of PHN patients from April 2017~December 2019. The patients’ sleep quality and quality of life were evaluated using the Pittsburgh sleep quality score and the SF- 36 scale, respectively. The serum levels of MECP2, CRP, IL -6 and TNF-α were tested using enzyme linked immunosorbent assay (ELISA). The pain condition of the patients was evaluated using the visual analogue scale (VAS). The levels of MECP2 were significantly increased in PHN patients compared with the patients without PHN. Serum MECP2 levels were the highest in patients with severe pain, and were the lowest in patients with mild pain. Similarly, the frequency of severe pain in patients with low expression of MECP2 was significantly lower than the patients with higher MECP2 expression. Besides, serum levels of inflammatory factors CRP, IL -6 and TNF-α were markedly increased in PHN patients, which were also increased with the increase of the severity of pain. CRP, IL -6 and TNF-α were positively correlated with serum levels of MECP2 in PHN patients. Before the study, patients with lower MECP2 levels showed a significantly higher SF-36 score and lower Pittsburgh and VAS scores than patients with higher levels of MECP2. However, after one month, no significant difference was found between the patients. ROC curve showed MECP2 had the potential as a diagnostic biomarker for PHN. In conclusion, higher serum MECP2 levels are associated with a more severe pain condition and increased release of inflammatory factors.

Resumen El objetivo de este estudio fue investigar la importancia clínica de la MECP2 en pacientes con neuralgia posherpética (NPH). Este estudio observacional prospectivo incluyó 319 pacientes con NPH entre abril de 2017 y diciembre de 2019. La calidad del sueño y la calidad de vida de los pacientes se evaluaron con la escala de calidad del sueño de Pittsburgh y la escala SF - 36, respectivamente. Los niveles séricos de MECP2, PCR, IL -6 y TNF-α fueron determinados por ELISA. Se utilizó la escala visual analógica (EVA) para evaluar la intensidad del dolor. Los niveles de MECP2 en pacientes con NPH aumentaron significativamente en comparación con los pacientes sin NPH. El nivel sérico de MECP2 fue más alto en pacientes con dolor grave y el más bajo en pacientes con dolor leve. Además, la incidencia de dolor grave en pacientes con baja expresión de MECP2 fue significativamente menor que en pacientes con alta expresión de MECP2. Además, los niveles séricos de PCR, IL -6 y TNF-α aumentaron significativamente en pacientes con NPH, y se incrementaron con el aumento del grado de dolor. Los niveles séricos de PCR, IL -6 y TNF-α en pacientes con NPH se correlacionaron positivamente con los niveles séricos de MECP2. Antes del estudio, los pacientes con niveles más bajos de MECP2 tenían puntuaciones significativamente más altas de SF - 36, y puntuaciones más bajas de Pittsburgh y EVA que los pacientes con niveles más altos de MECP2. Sin embargo, no se encontraron diferencias significativas entre los pacientes un mes después. Las curvas ROC mostraron que la MECP2 podría ser un biomarcador de diagnóstico para la NPH. En general, los niveles séricos más altos de la MECP2 se asociaron con condiciones de dolor más graves y un aumento de la liberación de factores inflamatorios.

Abstract Basic leucine zipper (bZIP) is a conserved transcription factor (TF) widely present in eukaryotes, and it plays an important role in regulating plant growth and stress responses. To better understand the white pear bZIP gene family, comprehensive bioinformatics analysis of the pear genome was performed. A total of 84 PbbZIP genes were identified, which were divided into 13 subfamilies by phylogenetic analysis. The 84 PbbZIP genes were all located in the nucleus, and 77 of those genes were unevenly distributed across the 17 chromosomes of white pear. The other 7 PbbZIP genes were located on the scaffold. Subsequent expression profile analysis showed that PbbZIP genes in exocarp were significantly upregulated or downregulated in ‘Huangguan’ pear with brown spot (BS) compared with healthy pear and in response to hormonal treatment with gibberellin A3 (GA3). These results provide helpful insights into the characteristics of PbbZIP genes and their responses to BS in ‘Huangguan’ pear.

Abstract Background This paper aims to assess the impact of antibiotic therapy management by clinical pharmacists on rational drug use (RDU) in the perioperative period of patients receiving retinal detachment surgery in China from the perspective of prescription structure. Methods: In this study, a retrospective study was used to compare the differences in the RDU between 233 patients (the experimental group) receiving medical treatment and 210 patients (the control group) without clinical pharmacist intervention. The data were collected with a set of indicators adjusted from the core medication use indicator proposed by the World Health Organization and the International Network of Rational Use of Drugs according to the background of China. Results: There were significant differences in average number of drugs per prescription (19.7 and 20.8, P = 0.001), percentage of drugs on the reimbursable list (98.32% and 72.4%, P = 0.003), and average treatment expenditure per prescription (555.3 yuan and 707 yuan) between the experimental group and the controlled group, while average number of antibiotics per prescription (4.2 and 4.3, P = 0.114), average number of injections per prescription (12.02 to 11.96, P = 0.804) were not changed significantly. Conclusions: More efforts are needed to improve the effectiveness of the antibiotic therapy management by clinical pharmacist on rational drug use, meanwhile the objective of cost-saving should be included in the service pattern of clinical pharmacy services.

Abstract The purpose of this paper is to determine the phytochemical composition and evaluate the nutritional value of qamgur (Brassica rapa L., a characteristic crop in Xinjiang). The fresh qamgur was processed with hot air drying and freeze drying and then sliced into FD qamgur slices and ground into qamgur powders. The results show that qamgur powders and FD qamgur slices are rich in the nutrients essential for human health, such as total sugar (41.4 and 44.8 g/100 g), polysaccharide (16.3 × 103 and 20.4 × 103 g/100 g), Vitamin C (39.3 and 46.5 g/100 g), flavonoids (45.0 and 33.0 g/100 g) and total saponins (46.0 and 30.0 g/100 g) compared with the fresh qamgur. Moreover, major elements and micro elements analysis were measured by inductively coupled plasma atomic emission spectrometry (ICP-AES), and the results showed that an abundant number of mineral elements (e.g. K, Na, Ca, Mg, Cu, Fe, Zn and Mn) were found in qamgur. The content of Ca was 4.5×103 mg/kg, 15.7 mg/kg for Zn, and 81.1 mg/kg for Fe. Similarly, the highest protein value was observed in the qamgur powders (12.4 g/100 g), whereas the fresh samples contained only 2.78 g/100 g. In addition, the proportion of essential amino acids (EAA) and nonessential amino acids (NEAA) of the powders were 59.7% and 40.3%, whereas for the FD slices, they were 61.0% and 39.0%. Overall, the nutritional value of qamgur was significantly improved through processing. So, in this paper, we provide the theoretical basis for the study on the nutritional value of qamgur and the development of medicinal foods and functional foods.