The present study analyzed the chemical composition and phytotoxic activity of Artemisia lancea essential oil (EO). Gas chromatography-mass spectrometry (GC-MS) results showed the presence of 55 compounds, representing 82.36% of the entire EO, with eucalyptol (18.7%) being the most abundant constituent. Phytotoxic bioassay results indicated that the EO (concentration ranging from 0.25-5 mg mL−1) inhibited the growth of Amaranthus retroflexus and Setaria viridis. Root length of A. retroflexus and S. viridis were reduced with the increasing concentration of the EO, especially when the EO was applied at 1-5 mg mL−1. When treated with 1-5 mg mL−1 EO, shoot length of A. retroflexus and S. viridis were also significantly suppressed. The half maximal inhibitory concentration (IC50) values for inhibiting root and shoot growth of A. retroflexus by the EO were 0.284 and 0.246 mg mL−1; for S. viridis, the EO showed IC50 values of 0.44 and 0.262 mg mL−1 for root and shoot inhibition, respectively. The most promising findings were observed when A. lancea EO concentration reached 1 mg mL−1 and higher, which completely inhibited seed germination of A. retroflexus and S. viridis. These findings suggest A. lancea EO has potential as an eco-friendly bioherbicide for agricultural weed control. EO. . (EO) chromatographymass chromatography mass GCMS GC MS (GC-MS 5 compounds 8236 82 36 82.36 18.7% 187 18 7 (18.7% constituent 0.255 0255 0.25 0 25 0.25- mL1 mL A S 15 1- mL− suppressed IC (IC50 0284 284 0.28 0246 246 0.24 IC5 044 44 0.4 0262 262 0.26 inhibition respectively higher ecofriendly eco friendly control (EO 823 8 3 82.3 18.7 (18.7 255 025 0.2 2 (IC5 028 28 024 24 04 4 0. 026 26 82. 18. (18. 02 (IC (18 (1 (

This research aims to develop a precise and efficient dispersive solid-phase microextraction (DSPE) technique using third-generation polyamidoamine (PAMAM) dendrimer-grafted nanoparticles to quantify benzoylurea pesticides in green tea, black tea, and oolong tea infusions. The extraction efficiency is optimized through single-factor adjustments of key parameters, including adsorbent quantity (5-20 mg), adsorption duration (5-20 min), desorbent identity (methanol, acetonitrile), volume (100-600 μL), sodium chloride concentration (0-10%, m/v), and sample solution pH (3-8). The optimized method demonstrates linearity in the range of 2-500 μg L-1, with limits of detection (LODs) ranging from 0.6-1.5 μg L-1 and limits of quantification (LOQs) from 2.0 5.0 μg L-1. Recovery rates of 81.2-96.0% are achieved, with intra-day relative standard deviations (RSDs) of 1.4-2.8% and inter-day relative standard deviations of 2.0-3.9%, indicating high accuracy and repeatability. The successful application of detecting residues in commercial tea samples underscores the strong potential of the technique to determine benzoylurea analyte levels. solidphase solid phase DSPE (DSPE thirdgeneration third generation PAMAM (PAMAM dendrimergrafted dendrimer grafted infusions singlefactor single factor parameters 520 5 20 (5-2 mg, mg , mg) min, min min) methanol, methanol (methanol acetonitrile, acetonitrile acetonitrile) 100600 100 600 (100-60 μL, μL μL) 010%, 010 0 10%, 10 (0-10% m/v, mv m/v m v m/v) 38. 38 3 8 . (3-8) 2500 2 500 2-50 L1, L1 L 1, 1 LODs (LODs 0.61.5 0615 0.6 1.5 6 0.6-1. L- LOQs (LOQs 2. 50 5. L1. 1. 81.296.0% 812960 81.2 96.0% 81 96 81.2-96.0 achieved intraday intra day RSDs (RSDs 1.42.8% 1428 1.4 2.8% 4 1.4-2.8 interday inter 2.03.9%, 2039 3.9%, 9 2.0-3.9% repeatability levels 52 (5- 10060 60 (100-6 010% 01 10% (0-10 (3-8 250 2-5 61 0.61. 061 06 0. 15 0.6-1 296 81.296.0 81296 812 81. 960 96.0 81.2-96. 42 1.42.8 142 14 28 2.8 1.4-2. 03 2.03.9% 203 39 3.9% 2.0-3.9 (5 1006 (100- (0-1 (3- 25 2- 0.61 0.6- 29 81.296. 8129 96. 81.2-96 1.42. 1.4-2 2.03.9 3.9 2.0-3. ( (100 (0- (3 81.296 81.2-9 1.42 1.4- 2.03. 3. 2.0-3 (10 (0 81.29 81.2- 2.03 2.0- (1

In order to extract hesperidin from Citrus aurantium L. through green and efficient ways, a novel method based on deep eutectic solvent (DES) assisted extraction has been developed. Compared to known alkali extraction and acid precipitation or organic solvent (ethanol, methanol) extraction, this new DES system of choline chloride/diethanolamine (DES-14) method exhibited excellent extraction efficiency for hesperidin. Under optimal conditions, the extraction yield of hesperidin reached 6.26 ± 0.05%. Further studies with infrared spectroscopy, 1H nuclear magnetic resonance, and density functional theory showed the DES-14 was formed mainly through the interaction of H-bond and van der Waals forces. In addition, scanning electron microscopy and density functional theory revealed the strong dissolving capacity, and the H-bond formation between DES-14 and hesperidin, as well as van der Waals forces all contributed to efficient extraction of hesperidin. The results provide a new strategy for efficient extraction and utilization of hesperidin in Citrus. L ways (DES developed ethanol, ethanol (ethanol methanol chloridediethanolamine chloride diethanolamine DES14 14 (DES-14 conditions 626 6 26 6.2 005 0 05 0.05% spectroscopy H resonance DES-1 Hbond bond addition capacity DES1 1 (DES-1 62 2 6. 00 0.05 DES- (DES- 0.0 0.

ABSTRACT Purpose: Ureteroplasty using buccal or lingual mucosa graft Is feasible for complex proximal ureteral stricture (1, 2). Ileal ureter replacement is considered as the last resort for ureteral reconstruction. Totally intracorporeal robot-assisted ileal ureter replacement can be performed safely and effectively (3). In China, the KangDuo Surgical Robot 2000 Plus (KD-SR-2000 Plus) has been developed featuring two surgeon consoles and five robotic arms. This study aims to share our experience with totally intracorporeal robot-assisted bilateral ileal ureter replacement using KD-SR-2000 Plus. Materials and Methods: A 59-year-old female patient underwent a complete intracorporeal robot-assisted bilateral ileal ureter replacement for the treatment of ureteral strictures using KD-SR-2000 Plus. The surgical procedure involved dissecting the proximal ends of the bilateral ureteral strictures, harvesting the ileal ureter, restoring intestinal continuity, and performing an anastomosis between the ileum and the ureteral end as well as the bladder. The data were prospectively collected and analyzed. Results: The surgery was successfully completed with single docking without open conversion. The length of the harvested ileal ureter was 25 cm. The docking time, operation time and console time were 3.4 min., 271 min and 231 min respectively. The estimated blood loss was 50 mL. The postoperative hospitalization was 6 days. No perioperative complications occurred. Conclusions: It is technically feasible to perform totally intracorporeal robot-assisted bilateral ileal ureter replacement for the treatment of ureteral strictures using KD-SR-2000 Plus. A longer follow-up and a larger sample size are required to evaluate its safety and effectiveness. Purpose 1, 1 (1 2. 2 . 2) reconstruction robotassisted robot assisted 3. 3 (3) China 200 KDSR2000 KDSR KD SR (KD-SR-200 arms KD-SR-200 Methods 59yearold yearold 59 year old continuity bladder analyzed Results conversion cm 34 4 min. 27 23 respectively 5 mL days occurred Conclusions followup follow up effectiveness ( (3 20 KDSR200 (KD-SR-20 KD-SR-20 KDSR20 (KD-SR-2 KD-SR-2 KDSR2 (KD-SR- KD-SR- (KD-SR KD-SR

ABSTRACT Objectives: To evaluate the safety and effectiveness of robot-assisted radical cystectomy (RARC), laparoscopic radical cystectomy (LRC), and open radical cystectomy (ORC) in bladder cancer. Methods: A literature search for network meta-analysis was conducted using international databases up to February 29, 2024. Outcomes of interest included baseline characteristics, perioperative outcomes and oncological outcomes. Results: Forty articles were finally selected for inclusion in the network meta-analysis. Both LRC and RARC were associated with longer operative time, smaller amount of estimated blood loss, lower transfusion rate, shorter time to regular diet, fewer incidences of complications, and fewer positive surgical margin compared to ORC. LRC had a shorter time to flatus than ORC, while no difference between RARC and ORC was observed. Considering lymph node yield, there were no differences among LRC, RARC and ORC. In addition, there were statistically significant lower transfusion rates (OR=-0.15, 95% CI=-0.47 to 0.17), fewer overall complication rates (OR=-0.39, 95% CI=-0.79 to 0.00), fewer minor complication rates (OR=-0.23, 95% CI=-0.48 to 0.02), fewer major complication rates (OR=-0.23, 95% CI=-0.68 to 0.21), fewer positive surgical margin rates (OR=0.22, 95% CI=-0.27 to 0.68) in RARC group compared with LRC group. Conclusion: LRC and RARC could be considered as a feasible and safe alternative to ORC for bladder cancer. Notably, compared with LRC, RARC may benefit from significantly lower transfusion rates, fewer complications and lower positive surgical margin rates. These data thus showed that RARC might improve the management of patients with muscle invasive or high-risk non-muscle invasive bladder cancer. Objectives robotassisted robot assisted RARC, , (RARC) (LRC) (ORC cancer Methods metaanalysis meta analysis 29 2024 characteristics Results metaanalysis. analysis. loss rate diet observed yield addition OR=0.15, OR015 OR OR= 0.15, 0 15 (OR=-0.15 95 CI=0.47 CI047 CI CI= 0.47 47 CI=-0.4 0.17, 017 0.17 17 0.17) OR=0.39, OR039 0.39, 39 (OR=-0.39 CI=0.79 CI079 0.79 79 CI=-0.7 0.00, 000 0.00 00 0.00) OR=0.23, OR023 0.23, 23 (OR=-0.23 CI=0.48 CI048 0.48 48 0.02, 002 0.02 02 0.02) CI=0.68 CI068 0.68 68 CI=-0.6 0.21, 021 0.21 21 0.21) OR=0.22, OR022 22 (OR=0.22 CI=0.27 CI027 0.27 27 CI=-0.2 068 Conclusion Notably highrisk high risk nonmuscle non (RARC (LRC 2 202 OR=0.15 OR01 015 0.15 1 (OR=-0.1 9 CI=0.4 CI04 047 0.4 4 CI=-0. 01 0.1 OR=0.39 OR03 039 0.39 3 (OR=-0.3 CI=0.7 CI07 079 0.7 7 0.0 OR=0.23 OR02 023 0.23 (OR=-0.2 048 CI=0.6 CI06 0.6 6 0.2 OR=0.22 (OR=0.2 CI=0.2 CI02 027 06 20 OR=0.1 OR0 (OR=-0. CI=0. CI0 04 0. CI=-0 OR=0.3 03 0.3 07 OR=0.2 (OR=0. OR=0. (OR=-0 CI=0 CI=- (OR=0 OR=0 (OR=- (OR= (OR

Abstract Objective To assess the outcome of patients with cancer-related sepsis requiring continuous renal replacement therapy (CRRT) in a single-center pediatric intensive care unit (PICU). Method Children with sepsis who necessitate CRRT from January 2017 to December 2021 were enrolled. The patients with leukemia/lymphoma or solid tumors were defined as underlying cancer. Multivariate logistic regression analysis was performed to identify the death risk factors in patients with cancer-related sepsis. Results A total of 146 patients were qualified for inclusion. Forty-six (31.5%) patients with cancer-related sepsis and 100 (68.5%) non-cancer-related sepsis. The overall PICU mortality was 28.1% (41/146), and mortality was significantly higher in cancer-related sepsis patients compared with non-cancer patients (41.3% vs. 22.0%, p = 0.016). Need mechanical ventilation, p-SOFA, acute liver failure, higher fluid overload at CRRT initiation, hypoalbuminemia, and high inotropic support were associated with PICU mortality in cancer-related sepsis patients. Moreover, levels of IL-6, total bilirubin, creatinine, blood urea nitrogen, and international normalized ratio were significantly higher in non-survivors than survivors. In multivariate logistic regression analysis, pediatric sequential organ failure assessment (p-SOFA) score (OR:1.805 [95%CI: 1.047-3.113]) and serum albumin level (OR: 0.758 [95%CI: 0.581 -0.988]) were death risk factors in cancer-related sepsis receiving CRRT, and the AUC of combined index of p-SOFA and albumin was 0.852 (95% CI: 0.730-0.974). Conclusion The overall PICU mortality is high in cancer-related sepsis necessitating CRRT. Higher p-SOFA and lower albumin were independent risk factors for PICU mortality. cancerrelated cancer related (CRRT singlecenter single center PICU. . (PICU) 201 202 enrolled leukemialymphoma leukemia lymphoma 14 inclusion Fortysix Forty six 31.5% 315 31 5 (31.5% 10 68.5% 685 68 (68.5% noncancerrelated non 281 28 1 28.1 41/146, 41146 41/146 , 41 (41/146) noncancer 41.3% 413 3 (41.3 vs 220 22 0 22.0% 0.016. 0016 0.016 016 0.016) ventilation pSOFA, pSOFA SOFA, SOFA initiation hypoalbuminemia Moreover IL6, IL6 IL 6, 6 IL-6 bilirubin creatinine nitrogen nonsurvivors survivors (p-SOFA OR1.805 OR1805 OR 1.805 805 (OR:1.80 95%CI 95CI CI 95 [95%CI 1.0473.113 10473113 1.047 3.113 047 113 1.047-3.113] (OR 0758 758 0.75 0581 581 0.58 0.988 0988 988 -0.988] 0852 852 0.85 95% (95 0.7300.974. 07300974 0.730 0.974 730 974 0.730-0.974) (PICU 20 31.5 (31.5 68.5 (68.5 2 28. 4114 41/14 4 (41/146 41.3 (41. 22.0 001 0.01 01 IL- OR1 OR1.80 OR180 1805 1.80 80 (OR:1.8 9 0473 1.0473.11 1047311 1047 1.04 3113 3.11 04 11 1.047-3.113 075 75 0.7 058 58 0.5 0.98 098 98 -0.988 085 85 0.8 (9 7300 0.7300.974 0730097 0730 0.73 0974 0.97 73 97 0.730-0.974 31. (31. 68. (68. 411 41/1 (41/14 41. (41 22. 00 0.0 OR1.8 OR18 180 1.8 8 (OR:1. 1.0473.1 104731 104 1.0 311 3.1 1.047-3.11 07 7 0. 05 0.9 09 -0.98 08 ( 0.7300.97 073009 073 097 0.730-0.97 (31 (68 41/ (41/1 (4 OR1. 18 1. (OR:1 1.0473. 10473 3. 1.047-3.1 -0.9 0.7300.9 07300 0.730-0.9 (3 (6 (41/ 1.0473 1.047-3. -0. 0.7300. 0.730-0. 1.047-3 -0 0.7300 0.730-0 1.047- - 0.730-

ABSTRACT Drought stress is a major limiting factor for soybean (Glycine max (L.) Merr.) growth and yield in arid and semi-arid regions. This study investigates the N content in different organs and the yield impact of two drought-tolerant soybean cultivars, Hei Nong44 and Hei Nong65, under varying drought intensities and re-watering at different growth stages. The results indicate that the effect of drought stress on N content varies with growth stage and organ. During the seedling and flowering stages, the ammoniacal N content in leaves and petioles of both cultivars generally decreased, with a reduction of 16.04%-21.95% during seedling stage and 6.46%-23.52% during flowering stage under severe drought (S), while it increased in stems. The nitrate N content in leaves peaked under moderate drought during the seedling stage and under severe drought during the flowering stage, increasing by 20.00% and 16.21%, 15.71% and 55.56% for ‘Hei Nong44’ and ‘Hei Nong65’, respectively, while it decreased in stems. During the pod-filling stage, ammoniacal N content increased in leaves and stems, with an increase of 20.99%-60.13% under S, while it showed a rising-then-falling trend in pods. Nitrate N content had the highest increase in leaves and stems, rising by 67.02%-69.31% under S, while it decreased in petioles with increasing drought severity. After re-watering, both cultivars showed some recovery in N content. Yield reduction was more significant during the flowering and pod-filling stages, decreasing by 17.45%-32.66% and 21.47%-35.63%, respectively.

Abstract Objective: To investigate the incidence, clinical and genetic characteristics of pediatric lymphoma patients of China with inborn errors of immunity (IEI)-related gene mutations, which have not been fully studied. Method: From Jan. 2020 to Mar. 2023, IEI-related genetic mutations were retrospectively explored in 108 children with lymphomas admitted to Beijing Children’s Hospital by NGS. Genetic rule and clinical characteristics as well as treatment outcomes were compared between patients with or without IEI-related gene mutations. Results: A total of 17 patients (15.7 %) harbored IEI-associated mutations, including 4 cases with X-linked lymphoproliferative syndrome (XLP), 3 cases had mutations in tumor necrosis factor receptor superfamily 13B (TNFRSF13B), 2 cases with Activated p110 syndrome (APDS). Patients with IEI all had alteration of immunocompetence with decreased levels of immunoglobulin and lymphocyte subsets. Recurrent infection existed in 41.2 % of patients. The 18-month event-free survival (EFS) and the overall response rate (ORR) of patients with IEI are significantly lower than those without IEI (33.86% vs. 73.26 %, p = 0.011; 52.94% vs. 87.91 %, p = 0.002, respectively). In addition, patients with IEI had a higher progression disease (PD) rate of 23.5 % than those without IEI of 4.4% (p = 0.006). Conclusion: The present study demonstrated that IEI-associated lymphomas were much more common than originally appreciated in pediatric lymphomas, and those were insensitive to treatment and more likely to progress or relapse. The genomic analysis and a thorough review of the medical history of IEI can be used to distinguish them from pediatric lymphomas without IEI, which are beneficial for the early diagnosis and direct intervention. Objective incidence IEIrelated related studied Method Jan 202 Mar 2023 10 Childrens Children s NGS Results 1 15.7 157 15 7 (15. IEIassociated associated Xlinked X linked XLP, XLP , (XLP) B TNFRSF13B, TNFRSF13B TNFRSFB TNFRSF (TNFRSF13B) p11 APDS. APDS . (APDS) subsets 412 41 41. 18month month 18 eventfree event free EFS (EFS ORR (ORR 33.86% 3386 33 86 (33.86 vs 7326 73 26 73.2 0.011 0011 0 011 5294 52 94 52.94 8791 87 91 87.9 0002 002 0.002 respectively. respectively respectively) addition PD (PD 235 23 5 23. 44 4.4 0.006. 0006 0.006 006 0.006) Conclusion relapse intervention 20 15. (15 (XLP (TNFRSF13B p1 (APDS 33.86 338 8 (33.8 732 73. 0.01 001 01 529 9 52.9 879 87. 000 00 0.00 4. (1 33.8 (33. 0.0 52. ( 33. (33 0. (3

Coal spontaneous combustion in longwall gobs is a major concern in coal mines. In comparison to other hazards, this phenomenon is difficult to detect. Fifteen factors influencing coal spontaneous combustion in longwall gobs were identified from the literature. The logical relationships between these factors were evaluated and quantified by decision-making trial and evaluation laboratory (DEMATEL) and interpretive structural modelling (ISM) methods. A four-level hierarchical structure model was established. The research shows that combining DEMATEL and ISM can reveal the key factors that influence coal spontaneous combustion in longwall gobs and establish the interactions and relationships among these factors. The results can provide the basis for preventing and controlling coal spontaneous combustion in longwall gobs.

Abstract Objectives: This study aimed to compare the intestinal and pancreatobiliary subtypes of ampullary adenocarcinoma in a large patient group due to limited data on survival and risk factors. Methods: A retrospective analysis of the clinical and pathological findings and the survival of 184 patients with ampullary adenocarcinoma who underwent curative operation between 2007 and 2018 was performed. Results: Pancreatobiliary subtype had a higher prevalence of jaundice before operation than the intestinal subtype (p < 0.05). Pancreatobiliary subtype had a larger tumor size (> 2 mm) (p < 0.01) and poorer differentiation (p < 0.05) than the intestinal subtype. Perineural invasion more frequently occurred in pancreatobiliary subtype than the intestinal subtype (p < 0.01) and pancreatobiliary subtype had a higher prevalence of positive dissected lymph nodes (p < 0.05) with an advanced disease stage (p < 0.01) than the intestinal subtype. Patients of the pancreatobiliary subtype had poorer disease-free and overall survival than patients of the intestinal subtype. No survival benefit of adjuvant chemotherapy was found in either patients of the intestinal subtype or pancreatobiliary subtype. No significant difference was found in any subtypes regarding the recurrent regions. Conclusions: Pancreatobiliary subtype exhibited a higher recurrence rate and a poorer overall survival rate with more unfavorable pathological characteristics than the intestinal subtype.

Resumen Objetivos: Los datos sobre la supervivencia y los factores de riesgo del adenocarcinoma ampular son limitados debido a su rareza. Este estudio buscó comparar el subtipo intestinal y el subtipo pancreático-biliar en pacientes con adenocarcinoma ampular. Métodos: Análisis retrospectivo de hallazgos clínicos y patológicos y la supervivencia de 184 pacientes con adenocarcinoma ampular tratados entre 2007 y 2018. Resultados: El subtipo pancreático-biliar tuvo una mayor prevalencia de ictericia antes de la operación y un tamaño de tumor mayor, y una peor diferenciación, que el subtipo intestinal. La invasión perineural fue más frecuente en el subtipo pancreático-biliar, con una mayor prevalencia de linfonodos disecados positivos y un estadio avanzado de la enfermedad. Los pacientes del subtipo pancreático-biliar tuvieron una supervivencia libre de enfermedad y una supervivencia general peores que los pacientes del subtipo intestinal. No se encontró ningún beneficio de la quimioterapia adyuvante en pacientes del subtipo intestinal o pancreático-biliar. No hubo diferencia significativa en las regiones recurrentes. Conclusión: El subtipo pancreático-biliar mostró una tasa de recurrencia y una tasa de supervivencia general peores, con características patológicas más desfavorables que el subtipo intestinal.

Abstract Excessive use of synthetic herbicides can cause environmental and public health problems, as well as herbicide-resistant weeds, so it is imperative to find a more sustainable method of weed management. In this study, twenty-nine accessions of two buckwheat species (Fagopyrum esculentum Moench (common buckwheat) and Fagopyrum tataricum (L.) Gaertn. (tartar buckwheat) were evaluated against two synthetic herbicide resistant weeds, the monocotyledonous Lolium rigidum Gaud. and the dicot Portulaca oleracea L. The results suggest that buckwheat accessions can sustainably manage both weed species through plant interference such as competition or allelopathy. We found that F. esculentum accessions were more effective against L. rigidum and F. tataricum accessions against both weeds. The study also included analysis of the chemical profile of the buckwheat accessions (plant polyphenol content) in order to relate it to the ability to sustainably manage weeds. Common buckwheat accessions showed more orietin, vitexin and hyperoside, while tartar buckwheat accessions showed higher amounts of rutin, quercetin and kaempferol which may be responsible for the different effects observed on weed growth. We propose that screening and selection of accessions with high polyphenol content and good growth may be a step towards organic farming due to their positive relationship with sustainable weed management.

Resumen El uso excesivo de herbicidas sintéticos puede generar problemas ambientales y de salud pública, además del desarrollo de malas hierbas resistentes, por lo que es imprescindible encontrar un método más sostenible de gestión de las malas hierbas. En este estudio se evaluó la capacidad de veintinueve cultivares pertenecientes a dos especies de trigo sarraceno Fagopyrum esculentum Moench (trigo sarraceno común) y Fagopyrum tataricum (L.) Gaertn. (trigo sarraceno tártaro) para controlar dos malas hierbas resistentes a herbicidas sintéticos, la monocotiledónea Lolium rigidum Gaud. y la dicotiledónea Portulaca oleracea L. Los resultados obtenidos sugieren que los cultivares de trigo sarraceno tiene un efecto sobre el crecimiento de ambas especies de malas hierbas a través de interferencias vegetales como la competencia y/o la alelopatía. En este estudio se encontró que los cultivares de F. esculentum fueron más efectivos frente a L. rigidum y los cultivares de F. tataricum frente a ambas malas hierbas. El estudio también incluyó el análisis del perfil químico de los cultivares de trigo sarraceno (contenido de polifenoles en la planta) para poder relacionarlo con su capacidad para manejar las malas hierbas de forma sostenible. Los cultivares de trigo sarraceno común mostraron más orientina, vitexina e hiperósido, mientras que los de trigo sarraceno tártaro presentaron mayores cantidades de rutina, quercetina y kaempferol, pudiendo ser responsables de los diferentes efectos observados sobre el crecimiento de las malas hierbas. Se propone así, a raíz de este estudio, el cribado y selección de cultivares con alto contenido en polifenoles y buen crecimiento para contribuir a un manejo sostenible de las malas hierbas en los sistemas agroecológicos

The transient infiltration and lubrication behaviour of slag during continuous casting of steel is important for billet quality. A two-dimensional coupled mathematical mould model was developed to investigate these phenomena. The accuracy of the model was verified by comparing the calculated slag consumption with measurements by the plant. The results show that the liquid slag is consumed from the middle and late period of positive strip time to the next early period of positive strip time, including the entire negative strip time. The maximum downward infiltration velocity and positive pressure in the slag channel is at the middle of the negative strip time. Increasing the positive pressure of the slag channel is conducive to lubrication. The shear stresses acting on the shell surface and at the mould side were determined by the lubrication slag consumption and total slag consumption, respectively, and gradually decreased with increasing slag consumption. The negative strip time was lengthened to increase the slag consumption and prolong the time near the maximum downward shear stress, so as to be conducive to the demould.

The lightly micro-polluted raw water of Yangtze River (YRW) in autumn was treated via enhanced coagulation by composite coagulants composed of polyaluminium chloride (PAC) and polydimethyldiallylammonium chloride (PDMDAAC), named PAC/PDMDAAC. Coagulation mechanism and removal efficiency were investigated by assessing the water quality parameters of the resulting supernatant, i.e. turbidity, COD Mn, and NH3-N, at the same dosage and supernatant turbidity (SDST) point as using PAC only, with controlled residual turbidity of 1.0-1.50 NTU to mimic drinking water production plant supernatant condition when using lightly micro-polluted water as raw water source . In addition, the zeta potential, floc morphology, and size analysis under the condition of SDST using PAC and composite coagulants PAC/PDMDAAC for getting insight about removal mechanism were done. The results showed that, firstly, most of the composite coagulants PAC/PDMDAAC with intrinsic viscosity [η] = 0.65, 1.60, and 2.6 dL/g; and mass ratio PAC:PDMDAAC of 5:1, 10:1, and 20:1 (mm)) could meet the requirements of controlled supernatant turbidity between 1.0 and 1.5 NTU to mimic drinking water production plant condition using YRW (Nanjing section) that comply with the new national drinking water standards. Secondly, the seven kinds of composite coagulants PAC/PDMDAAC can maintained the advantage of enhanced coagulation removal efficiency within the SDST point as using PAC only. The COD Mn and ammonia nitrogen removal rates using composite coagulants at SDST points were 0-6.19 %; 0-15.62%, respectively higher than using PAC only. Finally, this study deepened and expanded the existing research knowledge about composite coagulant PAC/PDMDAAC and offered the maximum limitations in removing the water quality parameters via enhanced coagulation treatment of lightly micro-polluted surface raw water in order to meet new national drinking water standards.

Resumo Fundamento A fibrilação atrial (FA) e a insuficiência cardíaca (IC) coexistem frequentemente, resultando em desfechos adversos. No entanto, permanecem controvérsias quanto à eficácia da ablação por cateter (AC) em pacientes com FA com disfunção ventricular esquerda grave. Objetivos O objetivo deste estudo foi realizar uma metanálise de ensaios prospectivos randomizados e controlados para avaliar a eficácia da AC versus terapia médica (TM) em pacientes com FA com fração de ejeção do ventrículo esquerdo (FEVE) ≤45%. Métodos Procuramos na literatura estudos que comparassem AC com TM em pacientes com FA com FEVE ≤45%. Foi realizada uma metanálise de 7 ensaios clínicos, incluindo 1.163 pacientes com FA e IC. A análise de subgrupo foi realizada com base na FEVE basal. Todos os testes foram bilaterais; apenas o valor p <0,05 foi considerado estatisticamente significativo. Resultados Descobrimos que a AC estava associada a menor mortalidade por todas as causas (taxa de risco: 0,52, IC 95%: 0,37 a 0,72; p<0,01) e maiores melhorias na FEVE (diferença média: 4,80%, IC 95%: 2,29% a 7,31%; p<0,01) em comparação com TM. Os pacientes do grupo AC apresentaram menor risco de hospitalização por IC e recorrência de FA e qualidade de vida significativamente melhor do que aqueles do grupo TM. Os resultados da análise de subgrupo indicaram que pacientes com disfunção ventricular esquerda mais leve melhoraram a FEVE após a ablação de FA (diferença média: 6,53%, IC 95%: 6,18% a 6,88%; p<0,01) em comparação com pacientes com doença mais grave (diferença média : 2,02%, IC 95%: 0,87% a 3,16%; p<0,01). Conclusões Nossa metanálise demonstrou que a AC foi associada a melhorias significativas nos resultados de pacientes com FA com FEVE ≤45%. Além disso, pacientes com FA com disfunção ventricular esquerda mais leve poderiam se beneficiar mais com a AC. (FA (IC frequentemente adversos entanto (AC (TM (FEVE 45 ≤45% clínicos 1163 1 163 1.16 basal bilaterais 005 0 05 <0,0 significativo taxa 052 52 0,52 95% 95 037 37 0,3 0,72 072 72 p<0,01 p001 01 diferença 480 4 80 4,80% 229 2 29 2,29 7,31% 731 31 653 6 53 6,53% 618 18 6,18 6,88% 688 88 202 02 2,02% 087 87 0,87 3,16% 316 3 16 p<0,01. . disso ≤45 116 1.1 00 <0, 5 0,5 9 03 0, 0,7 07 p<0,0 p00 48 8 4,80 22 2,2 7,31 73 65 6,53 61 6,1 6,88 68 20 2,02 08 0,8 3,16 ≤4 11 1. <0 p<0, p0 4,8 2, 7,3 6,5 6, 6,8 2,0 3,1 ≤ < p<0 4, 7, 3, p<

Abstract Background Atrial fibrillation (AF) and heart failure (HF) frequently coexist, resulting in adverse outcomes. However, controversies remain regarding the efficacy of catheter ablation (CA) in AF patients with severe left ventricular dysfunction. Objectives The purpose of this study was to perform a meta-analysis of prospective randomized controlled trials to evaluate the efficacy of CA versus medical therapy (MT) in AF patients with left ventricular ejection fraction (LVEF) ≤45%. Methods We searched the literature for studies that compared CA to MT in AF patients with LVEF ≤45%. A meta-analysis of 7 clinical trials was performed, including 1163 patients with AF and HF. Subgroup analysis was performed based on baseline LVEF. All tests were 2-sided; only the p-value <0.05 was considered statistically significant. Results We found that CA was associated with lower all-cause mortality (risk ratio: 0.52, 95% CI: 0.37 to 0.72; p<0.01) and greater improvements in LVEF (mean difference: 4.80%, 95% CI: 2.29% to 7.31%; p<0.01) compared to MT. Patients in the CA group had a lower risk of HF hospitalization and AF recurrence and a significantly better quality of life than those in the MT group. The results of subgroup analysis indicated that patients with milder left ventricular dysfunction improved LVEF after AF ablation (mean difference: 6.53%, 95% CI: 6.18% to 6.88%; p<0.01) compared to patients with more severe disease (mean difference: 2.02%, 95% CI: 0.87% to 3.16%; p<0.01). Conclusions Our meta-analysis demonstrated that CA was associated with significant improvements in outcomes of AF patients with LVEF ≤45%. Additionally, AF patients with milder left ventricular dysfunction could benefit more from CA. (AF (HF coexist However (CA metaanalysis meta (MT (LVEF 45 ≤45% 116 2sided sided 2 2-sided pvalue p value 005 0 05 <0.0 allcause all cause ratio 052 52 0.52 95 CI 037 37 0.3 0.72 072 72 p<0.01 p001 01 mean difference 480 4 80 4.80% 229 29 2.29 7.31% 731 31 653 6 53 6.53% 618 18 6.18 6.88% 688 88 202 02 2.02% 087 87 0.87 3.16% 316 3 16 p<0.01. . Additionally ≤45 11 00 <0. 5 0.5 9 03 0. 0.7 07 p<0.0 p00 48 8 4.80 22 2.2 7.31 73 65 6.53 61 1 6.1 6.88 68 20 2.02 08 0.8 3.16 ≤4 <0 p<0. p0 4.8 2. 7.3 6.5 6. 6.8 2.0 3.1 ≤ < p<0 4. 7. 3. p<