ABSTRACT Objective: The purpose of the present study was to examine the association of oxidative stress markers with sarcopenia in the general United States population under the age of 60. Methods: We used the National Health and Nutrition Examination Survey data from 2011‒2014 and performed Restricted Cubic Spline (RCS) plots, weighted multivariable logistic regression analysis to calculate ratio ratios and 95% Confidence Intervals, and subgroup analysis based on age, sex, hypertension, diabetes mellitus, and body mass index stratification to determine the association of markers of oxidative stress with the prevalence of sarcopenia. Results: The present analysis included a total of 8,782 participants. Firstly, the RCS plots showed a roughly L-shaped curve association of total bilirubin and serum iron with a prevalence of sarcopenia. Secondly, albumin was negatively and linearly associated with the risk of sarcopenia. Finally, with the increase in gamma-glutamyl transferase, the prevalence of sarcopenia showed a trend of first rising and then declining as a result of the iron increase. Conclusions: We demonstrated a nonlinear association between markers of oxidative stress and sarcopenia. The need to focus more on levels of oxidative stress in the body could provide better prevention strategies for sarcopenia. Objective 60 Methods 20112014 2011 2014 2011‒201 (RCS 95 Intervals sex hypertension mellitus Results 8782 8 782 8,78 participants Firstly Lshaped L shaped Secondly Finally gammaglutamyl gamma glutamyl transferase Conclusions 6 2011201 201 2011‒20 9 878 78 8,7 201120 20 2011‒2 87 7 8, 20112 2 2011‒

Abstract Objective This study investigated the relationship between PDZK1 expression and Dynamic Contrast-Enhanced MRI (DCE-MRI) perfusion parameters in High-Grade Glioma (HGG). Methods Preoperative DCE-MRI scanning was performed on 80 patients with HGG to obtain DCE perfusion transfer coefficient (Ktrans), vascular plasma volume fraction (vp), extracellular volume fraction (ve), and reverse transfer constant (kep). PDZK1 in HGG patients was detected, and its correlation with DCE-MRI perfusion parameters was assessed by the Pearson method. An analysis of Cox regression was performed to determine the risk factors affecting survival, while Kaplan-Meier and log-rank tests to evaluate PDZK1′s prognostic significance, and ROC curve analysis to assess its diagnostic value. Results PDZK1 was upregulated in HGG patients and predicted poor overall survival and progression-free survival. Moreover, PDZK1 expression distinguished grade III from grade IV HGG. PDZK1 expression was positively correlated with Ktrans 90, and ve_90, and negatively correlated with kep_max, and kep_90. Conclusion PDZK1 is upregulated in HGG, predicts poor survival, and differentiates tumor grading in HGG patients. PDZK1 expression is correlated with DCE-MRI perfusion parameters. PDZK ContrastEnhanced Contrast Enhanced DCEMRI (DCE-MRI HighGrade High Grade . (HGG) 8 Ktrans, , (Ktrans) vp, vp (vp) ve, ve (ve) kep. kep (kep) detected method KaplanMeier Kaplan Meier logrank log rank PDZK1s PDZKs s significance value progressionfree progression free Moreover 90 ve90 ve_90 kepmax max kep_max kep90 kep_90 (HGG (Ktrans (vp (ve (kep 9 ve9 ve_9 kep9 kep_9 ve_ kep_

Resumo Fundamento: O antibiótico quimioterápico antraciclina doxorrubicina (DOX) pode induzir cardiotoxicidade cumulativa e levar à disfunção cardíaca. RNAs não codificantes longos (lncRNAs) podem funcionar como importantes reguladores na lesão miocárdica induzida por DOX. Objetivo: Este estudo tem como objetivo investigar o papel funcional e o mecanismo molecular do RNA antisense lncRNA OXCT1 1 (OXCT1-AS1) na lesão celular miocárdica induzida por DOX in vitro. Métodos: Cardiomiócitos humanos (AC16) foram estimulados com DOX para induzir um modelo de lesão celular miocárdica. A expressão de OXCT1-AS1, miR-874-3p e BDH1 em células AC16 foi determinada por RT-qPCR. A viabilidade das células AC16 foi medida pelo ensaio XTT. A citometria de fluxo foi empregada para avaliar a apoptose de células AC16. Western blotting foi utilizado para avaliar os níveis proteicos de marcadores relacionados à apoptose. O ensaio repórter de luciferase dupla foi conduzido para verificar a capacidade de ligação entre miR-874-3p e OXCT1-AS1 e entre miR-874-3p e BDH1. O valor de p<0,05 indicou significância estatística. Resultados: A expressão de OXCT1-AS1 foi diminuída em células AC16 tratadas com DOX. A superexpressão de OXCT1-AS1 reverteu a redução da viabilidade celular e a promoção da apoptose celular causada pela DOX. OXCT1-AS1 está ligado competitivamente ao miR-874-3p para regular positivamente o BDH1. A superexpressão de BDH1 restaurou a viabilidade das células AC16 e suprimiu a apoptose celular sob estimulação com DOX. A derrubada do BDH1 reverteu a atenuação da apoptose de células AC16 mediada por OXCT1-AS1 sob tratamento com DOX. Conclusão: LncRNA OXCT1-AS1 protege células miocárdicas humanas AC16 da apoptose induzida por DOX através do eixo miR-874-3p/BDH1. Fundamento (DOX cardíaca lncRNAs (lncRNAs Objetivo OXCT OXCT1AS1 OXCTAS AS1 AS (OXCT1-AS1 vitro Métodos AC (AC16 OXCT1AS1, AS1, miR8743p miRp miR 874 3p p BDH AC1 RTqPCR. RTqPCR RT qPCR. qPCR RT-qPCR XTT OXCT1-AS p005 0 05 p<0,0 estatística Resultados Conclusão miR8743p/BDH1. miR8743pBDH1 miRpBDH 3p/BDH1. miR-874-3p/BDH1 OXCT1AS (OXCT1-AS (AC1 87 p00 p<0, miR8743p/BDH1 pBDH miR8743pBDH 3pBDH1 3p/BDH1 miR-874-3p/BDH (AC 8 p0 p<0 miR8743p/BDH 3pBDH 3p/BDH p<

Abstract Background: The anthracycline chemotherapeutic antibiotic doxorubicin (DOX) can induce cumulative cardiotoxicity and lead to cardiac dysfunction. Long non-coding RNAs (lncRNAs) can function as important regulators in DOX-induced myocardial injury. Objective: This study aims to investigate the functional role and molecular mechanism of lncRNA OXCT1 antisense RNA 1 (OXCT1-AS1) in DOX-induced myocardial cell injury in vitro. Methods: Human cardiomyocytes (AC16) were stimulated with DOX to induce a myocardial cell injury model. OXCT1-AS1, miR-874-3p, and BDH1 expression in AC16 cells were determined by RT-qPCR. AC16 cell viability was measured by XTT assay. Flow cytometry was employed to assess the apoptosis of AC16 cells. Western blotting was used to evaluate protein levels of apoptosis-related markers. Dual-luciferase reporter assay was conducted to verify the binding ability between miR-874-3p and OXCT1-AS1 and between miR-874-3p and BDH1. The value of p<0.05 indicated statistical significance. Results: OXCT1-AS1 expression was decreased in DOX-treated AC16 cells. Overexpression of OXCT1-AS1 reversed the reduction of cell viability and promotion of cell apoptosis caused by DOX. OXCT1-AS1 is competitively bound to miR-874-3p to upregulate BDH1. BDH1 overexpression restored AC16 cell viability and suppressed cell apoptosis under DOX stimulation. Knocking down BDH1 reversed OXCT1-AS1-mediated attenuation of AC16 cell apoptosis under DOX treatment. Conclusion: LncRNA OXCT1-AS1 protects human myocardial cells AC16 from DOX-induced apoptosis via the miR-874-3p/BDH1 axis. Background (DOX dysfunction noncoding non coding lncRNAs (lncRNAs DOXinduced induced Objective OXCT OXCT1AS1 OXCTAS AS1 AS (OXCT1-AS1 vitro Methods AC (AC16 model OXCT1AS1, AS1, miR8743p, miR8743p miRp miR 874 3p, 3p p BDH AC1 RTqPCR. RTqPCR RT qPCR. qPCR RT-qPCR apoptosisrelated related markers Dualluciferase Dual luciferase OXCT1-AS p005 0 05 p<0.0 significance Results DOXtreated treated stimulation OXCT1AS1mediated OXCTASmediated mediated treatment Conclusion miR8743p/BDH1 miR8743pBDH1 miRpBDH 3p/BDH1 miR-874-3p/BDH axis OXCT1AS (OXCT1-AS (AC1 87 p00 p<0. miR8743p/BDH pBDH miR8743pBDH 3pBDH1 3p/BDH (AC 8 p0 p<0 3pBDH p<

Abstract Background As a common disabling disease, irreversible neuronal death due to spinal cord injury (SCI) is the root cause of functional impairment; however, the capacity for neuronal regeneration in the developing spinal cord tissue is limited. Therefore, there is an urgent need to investigate how defective neurons can be replenished and functionally integrated by neural regeneration; the reprogramming of intrinsic cells into functional neurons may represent an ideal solution. Methods A mouse model of transection SCI was prepared by forceps clamping, and an adeno-associated virus (AAV) carrying the transcription factors NeuroD1 and Neurogenin-2(Ngn2) was injected in situ into the spinal cord to specifically overexpress these transcription factors in astrocytes close to the injury site. 5-bromo-2´-deoxyuridine (BrdU) was subsequently injected intraperitoneally to continuously track cell regeneration, neuroblasts and immature neurons marker expression, neuronal regeneration, and glial scar regeneration. In addition, immunoprotein blotting was used to measure the levels of transforming growth factor-β (TGF-β) pathway-related protein expression. We also evaluated motor function, sensory function, and the integrity of the blood-spinal cord barrier(BSCB). Results The in situ overexpression of NeuroD1 and Ngn2 in the spinal cord was achieved by specific AAV vectors. This intervention led to a significant increase in cell regeneration and the proportion of cells with neuroblasts and immature neurons cell properties at the injury site(p < 0.0001). Immunofluorescence staining identified astrocytes with neuroblasts and immature neurons cell properties at the site of injury while neuronal marker-specific staining revealed an increased number of mature astrocytes at the injury site. Behavioral assessments showed that the intervention did not improve The BMS (Basso mouse scale) score (p = 0.0726) and gait (p > 0.05), although the treated mice had more sensory sensitivity and greater voluntary motor ability in open field than the non-intervention mice. We observed significant repair of the BSCB at the center of the injury site (p < 0.0001) and a significant improvement in glial scar proliferation. Electrophysiological assessments revealed a significant improvement in spinal nerve conduction (p < 0.0001) while immunostaining revealed that the levels of TGF-β protein at the site of injury in the intervention group were lower than control group (p = 0.0034); in addition, P70 s6 and PP2A related to the TGF-β pathway showed ascending trend (p = 0.0036, p = 0.0152 respectively). Conclusions The in situ overexpression of NeuroD1 and Ngn2 in the spinal cord after spinal cord injury can reprogram astrocytes into neurons and significantly enhance cell regeneration at the injury site. The reprogramming of astrocytes can lead to tissue repair, thus improving the reduced threshold and increasing voluntary movements. This strategy can also improve the integrity of the blood-spinal cord barrier and enhance nerve conduction function. However, the simple reprogramming of astrocytes cannot lead to significant improvements in the striding function of the lower limbs.

Abstract Introduction: Propofol is a widely used anesthetic and its dose is closely related to aging. Telomere length (TL) is a unique heritable trait, and emerging as a biomarker of aging, health and disease. Telomerase RNA component (TERC) plays an important role in maintaining TL. We proposed a hypothesis that propofol dose in general anesthesia can be predicted by measuring TL before operation, which greatly reduced the risk of anesthesia, especially the elderly. Methods: The association between the propofol dose in anesthesia induction and: TL in the DNA of peripheral blood leukocytes; body weight; sex; difference of the Bispectral Index (BIS) before and after anesthesia induction in patients was evaluated by multivariable linear regression analyses. The mutation at the 5’end or 3’end of TERC was detected. We recruited 100 patients of elective surgery. Results: We found that propofol dose in anesthesia induction was clearly correlated significantly with TL (r = 0.78, p < 0.001), body weight (r = 0.84, p = 0.004), sex (r = 0.83, p= 0.84, p = 0.004), sex (r = 0.83, p = 0.004), and difference of BIS before and after anesthesia induction (r = 0.85, p = 0.029). By comparing the absolute values of standardized regression coefficients (0.58, 0.21, 0.19, and 0.12) of the four variables, it can be seen that TL contributes the most to the propofol dose in anesthesia induction. However, the mutation at the 5’ end or 3’ end of TERC was not found. Conclusions: These findings provide preliminary evidence that the propofol dose in anesthesia induction was clearly correlated with genetically determined TL. TL may be a promising predictor of the propofol dose, which is beneficial to improve the safety of anesthesia and reduce perioperative complications. Introduction aging (TL trait disease (TERC operation elderly Methods leukocytes (BIS analyses 5end 5 3end 3 detected 10 surgery Results r 078 0 78 0.78 0.001, 0001 0.001 , 001 0.001) 084 84 0.84 0.004, 0004 0.004 004 0.004) 083 83 0.83 085 85 0.85 0.029. 0029 0.029 . 029 0.029) 0.58, 058 58 (0.58 021 21 0.21 019 19 0.19 0.12 012 12 variables However Conclusions complications 1 07 7 0.7 000 0.00 00 08 8 0.8 002 0.02 02 0.58 05 (0.5 2 0.2 01 0.1 0. 0.0 0.5 (0. (0 (

ABSTRACT Purpose: To investigate the risk factors associated with adverse outcomes in patients with residual stones after percutaneous nephrolithotomy (PCNL) and to establish a nomogram to predict the probability of adverse outcomes based on these risk factors. Methods: We conducted a retrospective review of 233 patients who underwent PCNL for upper urinary tract calculi and had postoperative residual stones. The patients were divided into two groups according to whether adverse outcomes occurred, and the risk factors for adverse outcomes were explored by univariate and multivariate analyses. Finally, we created a nomogram for predicting the risk of adverse outcomes in patients with residual stones after PCNL. Results: In this study, adverse outcomes occurred in 125 (53.6%) patients. Multivariate logistic regression analysis indicated that the independent risk factors for adverse outcomes were the diameter of the postoperative residual stones (P < 0.001), a positive urine culture (P = 0.022), and previous stone surgery (P = 0.004). The above independent risk factors were used as variables to construct the nomogram. The nomogram model was internally validated. The calculated concordance index was 0.772. The Hosmer– Lemeshow goodness-of-fit test was performed (P > 0.05). The area under the ROC curve of this model was 0.772. Conclusions: Larger diameter of residual stones, positive urine culture, and previous stone surgery were significant predictors associated with adverse outcomes in patients with residual stones after PCNL. Our nomogram could help to assess the risk of adverse outcomes quickly and effectively in patients with residual stones after PCNL Purpose (PCNL Methods 23 analyses Finally Results study 12 53.6% 536 53 6 (53.6% P 0.001, 0001 0.001 , 0 001 0.001) 0.022, 0022 0.022 022 0.022) 0.004. 0004 0.004 . 004 0.004) validated 0772 772 0.772 Hosmer goodnessoffit goodness fit 0.05. 005 0.05 05 0.05) Conclusions 2 1 53.6 5 (53.6 000 0.00 00 002 0.02 02 077 77 0.77 0.0 53. (53. 07 7 0.7 0. (53 (5 (

Abstract Objective: To investigate the optimal timing of initial intravenous immunoglobulin (IVIG) treatment in Kawasaki disease (KD) patients. Methods: KD patients were classified as the early group (day 1-4), conventional group (day 5-7), conventional group (day 8-10), and late group (after day 10). Differences among the groups were analyzed by ANOVA and Chi-square analysis. Predictors of IVIG resistance and the optimal cut-off value were determined by multiple logistic regression analyses and receiver operating characteristic (ROC) curve analysis. Results: There were no significant differences in IVIG resistance among the 4 groups (p = 0.335). The sensitivity analysis also confirmed no difference in the IVIG resistance between those who started the initial IVIG ≤ day 7 of illness and those who received IVIG >day 7 of illness (p = 0.761). In addition, patients who received IVIG administration more than 7 days from the onset had a higher proportion of coronary artery abnormalities (p = 0.034) and longer length of hospitalization (p = 0.033) than those who started IVIG administration less than 7 days. The optimal cut-off value of initial IVIG administration time for predicting IVIG resistance was >7 days, with a sensitivity of 75.25% and specificity of 82.41%. Conclusions: IVIG therapy within 7 days of illness is found to be more effective for reducing the risk of coronary artery abnormalities than those who received IVIG >day 7 of illness. IVIG treatment within the 7 days of illness seems to be the optimal therapeutic window of IVIG. However, further prospective studies with long-term follow-up are required. Objective (IVIG (KD Methods 14, 14 1 , 1-4) 57, 57 5 5-7) 810, 810 8 10 8-10) after 10. . 10) Chisquare Chi square cutoff cut off ROC (ROC Results p 0.335. 0335 0.335 0 335 0.335) 0.761. 0761 0.761 761 0.761) addition 0.034 0034 034 0.033 0033 033 > 7525 75 25 75.25 8241 82 41 82.41% Conclusions However longterm long term followup follow up required 1-4 5-7 81 8-10 0.33 33 076 0.76 76 0.03 003 03 752 2 75.2 824 82.41 1- 5- 8-1 0.3 3 07 0.7 0.0 00 75. 82.4 8- 0. 82.

Resumen Objetivo. Investigar la seguridad y la eficacia de la discectomía endoscópica percutánea (DEP) y de la discectomía fenestrada (DF) en el tratamiento de la hernia de disco lumbar. Método. Se analizaron retrospectivamente los datos clínicos completos de 87 pacientes con hernia de disco lumbar. De acuerdo con el tratamiento prescrito, los pacientes fueron divididos en grupo control (DF, n = 39) y grupo de estudio (DEP, n = 48). Se compararon las condiciones básicas de funcionamiento de los dos grupos y se evaluaron los resultados de la cirugía, la incidencia de complicaciones y la calidad de vida al año de la operación. Resultados. Ambos grupos completaron la operación. En el grupo de estudio, las puntuaciones en la escala visual análoga y ODI disminuyeron significativamente, mientras que las puntuaciones JOA aumentaron significativamente. La tasa de éxito de la operación en el grupo de estudio fue significativamente mayor que en el grupo control, y la incidencia de complicaciones fue significativamente menor que en el grupo control. No hubo diferencia significativa en la calidad de vida entre los dos grupos (p > 0.05). Conclusiones. La tasa de éxito del tratamiento con DEP fue mayor, y el tiempo de recuperación fue más rápido y más seguro que con la DF.

Abstract Background. The aim of the study was to explore the safety and efficacy of percutaneous transforaminal endoscopic discectomy (PTED) and fenestration discectomy (FD) in the treatment of lumbar disc herniation (LDH). Material and methods. The complete clinical data from 87 patients with LDH from our hospital were retrospectively analyzed. Patients were divided into a control group (n = 39, treated with FD) and a research group (n = 48, treated with PTED) according to the prescribed treatments. The basic operation conditions were compared across the two groups. Surgical outcomes were assessed. The incidences of complications and the life quality of patients were evaluated 1 year after surgery. Results. The patients in both groups completed the operation. The visual analog scale and Oswestry Disability Index score of patients in the research group was significantly lower while the Orthopaedic Association Score was significantly higher after surgery. The success rate of the operation in the research group which was significantly higher and the rate of complications was significantly lower. No statistical differences in the quality of life were observed between the patients (p > 0.05). Conclusions. PTED and FD are effective in the treatment of LDH. However, our study showed that PTED has a higher rate of treatment success, faster recovery times and is safer than FD.

Abstract Flos Sophorae (FS) is medicinal and edible, while fresh FS is highly perishable. Thus, this study investigated the effects of different drying methods (hot air drying, HAD; vacuum drying, VD; freeze drying, FD) after steaming on the bioactive components and sensory quality of FS. The results indicated steaming for 1 min maximally retained the contents of total flavonoids, rutin, and quercetin in thermal drying (HAD and VD), meanwhile, the freeze-dried FS without steaming also had higher total flavonoids and rutin contents. Moreover, FD samples had the highest protein content and organoleptic properties, with closer color parameters to fresh FS, followed by the VD group. Considering comprehensively all data with processing cost, the sample of VD after steaming for 1 min was chosen to measure the antioxidant activity, which showed that FS extract was superior to Vc in ABTS• and •OH scavenging rates, and its DPPH• scavenging rate was stronger than Vc in the low concentration. These results demonstrated that vacuum drying after steaming for 1 min was suitable postharvest processing for fresh FS, which was beneficial to maintaining higher flavonoids, rutin, and sensory characteristics of FS, and its flavonoid extract had better antioxidant activity than Vc.

RESUMEN Introducción: El baloncesto contemporáneo se ha vuelto más competitivo y agresivo en el proceso de competición, aumentando también los correspondientes riesgos deportivos. Objetivo: Analizar los riesgos de lesiones derivados del baloncesto y estudiar los efectos que el entrenamiento del equilibrio postural tiene sobre ellos. Métodos: Se llevó a cabo un experimento controlado, en el que el grupo experimental empleó el entrenamiento del equilibrio y el grupo de control adoptó el entrenamiento físico general. Cada entrenamiento duró una hora, dos veces por semana, y el periodo experimental fue de 9 semanas. Resultados: Las puntuaciones totales de FMS de los dos grupos mejoraron antes y después del entrenamiento deportivo, y las puntuaciones de FMS del grupo de control aumentaron de 14,71 a 15,15, lo que demuestra que no hubo diferencias significativas (P>0,05). La puntuación total de FMS en el grupo experimental aumentó de 14,38 a 17,69, muy superior a la del grupo experimental. Se comprobó que había una diferencia muy significativa. Conclusión: El método propuesto en este trabajo puede aumentar eficazmente la capacidad de equilibrio postural de los atletas, reduciendo así el riesgo de lesiones deportivas en el desarrollo del deporte. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento. Introducción competición deportivos Objetivo ellos Métodos controlado general hora semana semanas Resultados deportivo 1471 14 71 14,7 1515 15 15,15 P>0,05. P005 P P>0,05 . 0 05 (P>0,05) 1438 38 14,3 1769 17 69 17,69 significativa Conclusión atletas deporte II tratamiento 147 1 7 14, 151 15,1 P00 P>0,0 (P>0,05 143 3 176 6 17,6 15, P0 P>0, (P>0,0 17, P>0 (P>0, P> (P>0 (P> (P

RESUMO Introdução: O basquetebol contemporâneo tornou-se mais competitivo e agressivo no processo de competição, aumentando também os riscos esportivos correspondentes. Objetivo: Analisar os riscos de lesão decorrentes do basquetebol e estudar os efeitos que o treinamento de equilíbrio postural tem sobre eles. Métodos: Foi realizado um experimento controlado, no qual o grupo experimental empregou treinamento de equilíbrio e o grupo de controle adotou treinamento físico geral. Cada treinamento durou uma hora, duas vezes por semana, e o período experimental foi de 9 semanas. Resultados: As pontuações totais de FMS dos dois grupos foram aperfeiçoadas antes e depois do treinamento esportivo, e as pontuações de FMS do grupo controle foram elevadas de 14.71 para 15.15, mostrando que não houve diferença significativa (P>0.05). A pontuação total do FMS no grupo experimental aumentou de 14.38 para 17.69, muito superior à do grupo experimental. Constatou-se que houve uma diferença muito significativa. Conclusão: O método proposto neste trabalho pode aumentar efetivamente a capacidade de equilíbrio postural dos atletas, reduzindo assim o risco de lesões esportivas no desenvolvimento do esporte. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento. Introdução tornouse tornou se competição correspondentes Objetivo eles Métodos controlado geral hora semana semanas Resultados esportivo 1471 14 71 14.7 1515 15 15.15 P>0.05. P005 P P>0.05 . 0 05 (P>0.05) 1438 38 14.3 1769 17 69 17.69 Constatouse Constatou Conclusão atletas esporte II tratamento 147 1 7 14. 151 15.1 P00 P>0.0 (P>0.05 143 3 176 6 17.6 15. P0 P>0. (P>0.0 17. P>0 (P>0. P> (P>0 (P> (P

ABSTRACT Introduction: Contemporary basketball has become more competitive and aggressive in the competition process, increasing the corresponding sport's risks. Objective: Analyze the injury risks arising from basketball and study the effects that postural balance training has on them. Methods: A controlled experiment was conducted, in which the experimental group used balance training and the control group used general physical training. Each training lasted one hour, twice a week, and the experimental period was nine weeks. Results: The total FMS scores of the two groups were improved before and after sports training, and the FMS scores of the control group were raised from 14.71 to 15.15, showing no significant difference (P>0.05). The total FMS score in the experimental group increased from 14.38 to 17.69, much higher than the experimental group. It was found that there was a very significant difference. Conclusion: The method proposed in this paper can effectively increase the postural balance ability of athletes, thus reducing the risk of sports injuries in the development of sports. Level of evidence II; Therapeutic studies - investigation of treatment results. Introduction process sport s Objective them Methods conducted hour week weeks Results 1471 14 71 14.7 1515 15 15.15 P>0.05. P005 P P>0.05 . 0 05 (P>0.05) 1438 38 14.3 1769 17 69 17.69 Conclusion athletes II results 147 1 7 14. 151 15.1 P00 P>0.0 (P>0.05 143 3 176 6 17.6 15. P0 P>0. (P>0.0 17. P>0 (P>0. P> (P>0 (P> (P

Abstract This study proposes a novel method for jujube maturity and water content determination incorporating fractal theory. Firstly, the tissue section images of winter jujube at different maturity and tissue section image images of winter jujube with different moisture content were preprocessed by grayscale, median filter, histogram equalization and binarization. Secondly, the fractal dimension of jujube tissue section images of jujube at different maturity, and the fractal dimension of tissue slice images of jujube with different moisture content were calculated based on the box dimension algorithm. Finally, the relationships of the fractal dimension-maturity and fractal dimension-moisture content were explored. The results showed that the fractal features had good discrimination performance, the fractal dimension decreased with the increase of maturity, and the fractal dimension decreased with the increase of moisture content. This study provides a new way of thinking about the detection of physical and chemical indicators of winter jujube and other fruits. theory Firstly grayscale filter binarization Secondly algorithm Finally dimensionmaturity dimensionmoisture explored performance fruits

Resumen: Debido a varias razones históricas y realistas, el desarrollo de la teoríeorlsica de la mlsica en China se queda atrátrra cuanto al sistema de enseñanza, el contenido de la enseñanza y otros aspectos. Es una tarea importante para los trabajadores chinos de la misica revisar o complementar la teoríeorteorntar sica actual y los libros de texto relacionados, y luego construir un sistema de disciplina de la teoríeorla teordesica en China. Este artículo sintetiza las teoríeorreorr educacióducacirr las tehistoria de la m sica, la cultura musical, la morfologíorfolog, la otras disciplinas relacionadas, utiliza valores científicos, objetivos y racionales y conceptos holísticos y comprensivos, toma el desarrollo de la educacióducaciedteoríeoracieducacsica de China como objeto de investigaciónvesttoma la historia como espejo para seguir considerando y prospectar la construccióonstrusistema de disciplina de la teoríeorla teordesica de China. Los fundamentos de la mtsica china pueden dividirse, a grandes rasgos, en tres periodos: (1) desde principios del siglo XX hasta la fundacióundacita la blica Popular China; (2) desde ese momento hasta el periodo de reforma y apertura; y (3) desde el periodo de reforma y apertura hasta la actualidad. La teoríeor teord. La teord. evolucionóvoluciond. La teord. Lfundacióundaciond. Lblica Popular China a travéravulun proceso de aceptaciócepasiva y absorcióbsactiva, como puede observarse en el desarrollo de la enseñanza de la teoríeorla teorde la ene lasica china y sus materiales didrcticos. La teoríeor teora teordidiales dpropagórprincipalmente desde el palacio a la iglesia, luego a las escuelas y finalmente a la sociedad. Como resultado, la enseñanza de la teoría musical china evolucionóvprogresivamente hacia un sistema menor mayor como modo dominante, y los fundamentos de la mtsica china se desviaron gradualmente. Tras el establecimiento de la Repiblica Popular China, la investigaciónvestigaciina, lprofundizado, lo que ha beneficiado el crecimiento de la disciplina de la teoríeorla teorbásica, que ahora se dirige hacia la diversificacióiversifprofundidad. El desarrollo de la teoríeorla teorde la teor teor de la tecontado con la ayuda de varios music musicusieducadores musicales de diversos campos académicos y puntos de vista de la investigaciónvestimodelo ideal de la construccióonstruccdisciplina de la teoríeorla teorde la teoconcibe sobre la base del principio de “combinar la historia con la teoríeor la tpeinar el desarrollo de la teoríeorla teordesica en China. Este modelo fomenta la integracióntegraciteoríeorgracirasica tradicional y la teoríeora teorlsica moderna desde una perspectiva diacrónica, refuerza la unidad del padel pal pmundo en la teoríeorla teorsica bcsica desde una perspectiva sincrónica, y presta atenciótenciiaconnotacióonnotacitecnología en su conjunto. Resumen realistas aspectos relacionados morfologíorfolog relacionadas científicos comprensivos dividirse rasgos periodos 1 (1 2 (2 3 (3 actualidad teord evolucionóvoluciond Lfundacióundaciond absorcióbsactiva didrcticos iglesia sociedad resultado dominante gradualmente investigaciónvestigaciina lprofundizado teorbásica diversificacióiversifprofundidad combinar diacrónica sincrónica conjunto (

Abstract: Due to various historical and realistic reasons, the development of basic music theory in China lags behind in the teaching system, teaching content and other aspects. It is an important task for Chinese music workers to revise or supplement the current basic music theory and related textbooks and then build a discipline system of basic music theory in China. This paper synthesizes the theories of music education and music history, music culture, music morphology and other related disciplines. It uses scientific, objective and rational values and holistic and comprehensive concepts. It takes the development of the basic music theory education of China as the research object and takes history as a mirror to further consider and prospect the construction of the basic music theory discipline system of China. The basic theory of Chinese Music can be roughly divided into three stages: (1) The basic music theory from the early 20th century to the founding of the People’s Republic of China; (2) From the founding of the People’s Republic of China to the period of reform and opening up; (3) Basic music theory compiled and published since the reform and opening up. It can be seen, from the development of the basic theory education of Chinese Music and its teaching materials, that the development of western music theory in China, before the founding of the People’s Republic of China, was a process from passive acceptance to active absorption. The scope of spreading western music theory was from the palace to the church, then to the school, and, finally, to the society, which made the music theory teaching in China gradually develop into a major and minor system as the leading mode. The basic theory of Chinese Music gradually deviated from its own track. With the deepening of music research after the founding of the People’s Republic of China, the discipline development of basic music theory has witnessed a prosperous situation, and the construction of basic music theory is moving towards the direction of diversification and deepening. Many musicologists and music educators have made contributions to the construction of basic music theory in China from different disciplines and research perspectives. Based on the principle of “combining history with the theory” and combing the development of basic music theory in China, the ideal model of Chinese music theory discipline construction is conceived to promote the integration between traditional music theory and modern music theory from a diachronic perspective What is relevant to strengthen the unity of the nation and the world in basic music theory from a synchronic perspective, and to pay attention to the connotation of technology and culture in music theory teaching. But also to strengthen the scientific and logical concept in music theory textbooks. Abstract reasons aspects concepts stages 1 (1 th Peoples People s 2 (2 up 3 (3 seen materials absorption church school finally society mode track situation perspectives combining (

RESUMEN Introducción: Las características del baloncesto exigen jugadores excelentes con habilidades atléticas como una gran fuerza explosiva para el salto instantáneo, movimientos flexibles y rápidos cambios de dirección, así como pases y tiros precisos. Son características que también se pueden encontrar en los juegos de playa y se cree que la práctica de estos juegos puede aportar algún beneficio a la práctica del baloncesto. Objetivo: Explorar el efecto del entrenamiento en la playa sobre la aptitud física de los jugadores de baloncesto. Métodos: Mediante un ensayo controlado aleatorio, se seleccionaron 24 jugadores de baloncesto para analizar la potencia explosiva de la extremidad inferior en la carrera de velocidad de 40 metros y en el salto vertical, dos indicadores representativos de la potencia explosiva de las extremidades inferiores. El experimento de enseñanza en grupo se llevó a cabo durante 17 semanas, cinco veces por semana. Resultados: La comparación en la prueba estadística del sprint de 40 metros y del salto vertical antes y después del experimento demuestra que, en comparación con la práctica tradicional del baloncesto, la práctica de los juegos de playa tiene un efecto beneficioso en la mejora de la potencia explosiva de los miembros inferiores. Conclusión: El entrenamiento deportivo en la playa aporta beneficios a la práctica del baloncesto, esto fue determinado por las características en la cancha de baloncesto en la playa y las características de jugabilidad de los atletas. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento. Introducción instantáneo dirección precisos Objetivo Métodos aleatorio 2 4 inferiores 1 semanas semana Resultados Conclusión atletas II tratamiento

RESUMO Introdução: As características do basquetebol exigem excelentes jogadores com habilidades atléticas como alta força explosiva para o salto instantâneo para cima, movimentos flexíveis e mudanças rápidas de direção, além de passes e tiros precisos. Essas são características que também podem ser encontradas nos jogos de praia e acredita-se que a prática desses jogos possa trazer algum benefício para a prática do basquetebol. Objetivo: Explorar o efeito do treinamento na praia sobre a aptidão física dos jogadores de basquetebol. Métodos: Através de um estudo randomizado controlado, foram selecionados 24 jogadores de basquetebol para analisar o poder explosivo da extremidade inferior no sprint de corrida de 40m e no salto vertical, dois indicadores representativos do poder explosivo dos membros inferiores, foram selecionados. O experimento de ensino em grupo foi realizado durante 17 semanas, cinco vezes por semana. Resultados: A comparação no teste estatístico dos 40m de sprint e do salto vertical antes e depois do experimento prova que, comparado com a prática tradicional do basquetebol, a prática dos jogos de praia tem um efeito benéfico na melhoria da potência explosiva dos membros inferiores. Conclusão: O treinamento com esporte de praia traz benefícios para a prática do basquetebol, isto foi determinado pelas características na quadra de basquetebol de praia e pelas características de jogabilidade dos esportistas. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento. Introdução cima direção precisos acreditase acredita se Objetivo Métodos controlado 2 m inferiores 1 semanas semana Resultados Conclusão esportistas II tratamento

ABSTRACT Introduction: The characteristics of basketball require excellent players with athletic abilities such as high explosive strength for the instantaneous jump up, flexible movements and quick changes of direction, and accurate passing and shooting. These characteristics can also be found in beach games, and it is believed that the practice of these games can benefit the practice of basketball. Objective: Explore the effect of beach training on the physical fitness of basketball players. Methods: Through a randomized controlled trial, 24 basketball players were selected to analyze the explosive power of the lower extremity in the 40m sprint race and in the vertical jump, two representative indicators of the explosive power of the lower limbs. The group teaching experiment was conducted for 17 weeks, five times a week. Results: The comparison in the statistical test of the 40m sprint, and the vertical jump before and after the experiment proves that, compared with the traditional practice of basketball, the practice of beach games has a beneficial effect on improving the explosive power of the lower limbs. Conclusion: Beach sports training has benefits for basketball practice; the characteristics on the beach basketball court and the playing characteristics of the athletes determined this. Level of evidence II; Therapeutic studies - investigation of treatment outcomes. Introduction up direction shooting Objective Methods trial 2 m limbs 1 weeks week Results Conclusion this II outcomes

Abstract Objective: To investigate the expression level and significance of T cell immunoglobulin and mucin-domain containing molecules-3 (Tim-3) and interleukin-7 (IL-7) in CD4+ T lymphocytes in peripheral blood of patients with coronary heart disease (CHD). Methods: 75 patients with CHD treated at our hospital were selected and classified as mild group (25 cases), moderate group (25 cases) and severe group (25 cases), according to the severity of illness. Twenty-five healthy volunteers who underwent a physical examination at our hospital during the same period were selected as the control group. The expression level of Tim-3 in CD4+ T lymphocytes in peripheral blood of patients in four groups was detected by flow cytometry and quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR). The expression level of IL-7 in peripheral blood serum was measured by enzyme-linked immunosorbent assay (ELISA). Correlation analyses of Tim-3 and IL-7, Tim-3 and disease severity and IL-7 and disease severity were performed, respectively. Results: Flow cytometry and qRT-PCR demonstrated that the expression of Tim-3 in CD4+ T lymphocytes in peripheral blood of patients with CHD increased with the aggravation of the disease. ELISA showed that the tendency of IL-7 expression in peripheral blood serum was consistent with the expression of Tim-3, and the expression of Tim-3 had a positive correlation with IL-7. The expression levels of both Tim-3 and IL-7 were positively correlated with the Gensini score. Conclusion: The expression of Tim-3 and IL-7 in peripheral blood of patients with CHD was upregulated and increased with the aggravation of CHD.

Abstract This paper explores the influence of the selection method of the region of interest (ROI) on the results in the total sugar of apple detection based on hyperspectral imaging technology. Taking Fuji apple as the detection object, the hyperspectral images of the samples were collected based on the 900~1750 nm hyperspectral imaging system, and the total sugar content of the samples was obtained based on the anthrone colorimetric method. The square ROI and circular ROI of different sizes were extracted. The average spectrum of the region was used to establish a quantitative analysis model of apple's total sugar content by partial least squares (PLS). The results show that apple's total sugar detection model established by extracting a circular ROI with a diameter of 25 pixels has the highest accuracy and strongest prediction ability(Rc = 0.8977, RMSEC = 0.6459, RP = 0.8836, RMSEP = 0.6627). The research shows that selecting ROI with a suitable shape and size for the research object is of great significance for improving the accuracy of the prediction model of apple's total sugar content and giving play to the advantages of hyperspectral images.