ABSTRACT Purpose: To determine the clinical outcomes in patients after type 1 Boston keratoprosthesis surgery and the significance of ultrasound biomicroscopy imaging for postoperative follow-up. Methods: This retrospective analysis included 20 eyes of 19 patients who underwent corneal transplantation with type 1 Boston keratoprosthesis between April 2014 and December 2021. Data on patient demographics, preoperative diagnosis, visual acuity, and postoperative clinical findings were analyzed. Results: Type 1 Boston keratoprosthesis implantation resulted in intermediate- and long-term positive outcomes. However, blindness and other serious complications such as glaucoma, retroprosthetic membrane formation, endophthalmitis, or retinal detachment also occurred. The use of ultrasound biomicroscopy imaging allowed for better evaluation of the back of the titanium plate, anterior segment structures, and the relationship of the prosthesis with surrounding tissues, which provided valuable postoperative information. Conclusion: Regular lifetime monitoring and treatment are necessary in patients who undergo Boston type 1 keratoprosthesis implantation for high-risk corneal transplantation. ultrasound biomicroscopy imaging can be a valuable imaging technique for the evaluation of patients with Boston type 1 keratoprosthesis, providing important information on anterior segment anatomy and potential complications. Further studies and consensus on postoperative follow-up protocols are required to optimize the management of patients with Boston type 1 keratoprosthesis. Purpose followup. followup follow up. up Methods 2 201 2021 demographics diagnosis acuity analyzed Results intermediate longterm long term However glaucoma formation endophthalmitis occurred plate structures tissues Conclusion highrisk high risk 202

RESUMO: Este estudo avaliou diferentes atores de extensão na região do Egeu em termos de indicadores-chave que influenciam o sucesso das atividades de extensão. Junto com o objetivo principal, foram investigados os fatores que afetam a satisfação dos extensionistas com suas condições de trabalho. Os dados foram recolhidos através de questionários a 966 extensionistas que trabalham em empresas públicas, privadas, organizações de agricultores, comerciantes de insumos e consultoria em oito províncias da região. De acordo com os resultados, 80% dos agricultores recebem serviços de extensão de organizações públicas da região. Enquanto aqueles que trabalham no setor público estão mais satisfeitos economicamente, sua satisfação profissional é a mais baixa. Habilidades pessoais dos extensionistas, compartilhamento de ideias, criatividade e harmonia autoridade-responsabilidade, liberdade de trabalho, disponibilidade e apoio da equipe estão aumentando a satisfação com as condições de trabalho nas organizações. Enquanto as agricultoras são mais visadas pelo público e por consultores, as agricultoras educadas têm mais prioridade em empresas, revendedores e consultas. A internalização de valores inovadores é menor nas organizações públicas em relação às demais. Prevê-se que, o público realizará extensão em países em desenvolvimento por muito tempo. O sucesso nas organizações de extensão no processo de inovação e estrutura pluralista de hoje tornou-se muito mais dependente das relações com o setor privado, mecanismos de mercado nacional e internacional, aconselhamento orientado pela demanda e políticas governamentais sociais, econômicas e ambientais. RESUMO indicadoreschave indicadores chave principal 96 privadas resultados 80 economicamente baixa ideias autoridaderesponsabilidade, autoridaderesponsabilidade autoridade responsabilidade, responsabilidade autoridade-responsabilidade consultores consultas demais Prevêse Prevê se tempo tornouse tornou privado internacional sociais ambientais 9 8

ABSTRACT: This study assessed different extension actors in the Aegean region in terms of key indicators that influence the success of extension activities. Along with the primary goal, factors affecting extensionists’ satisfaction with their working conditions were investigated. The data were collected through questionnaires from 966 extensionists working in public, private firms, farmer organizations, input dealers and consultancy in eight provinces in the region. According to the results, 80% of the farmers received extension services from public organizations in the region. While those who work in the public sector are more satisfied economically, their professional satisfaction is the lowest. Extension workers’ personal skills, sharing ideas, creativity, and authority-responsibility harmony, working freedom, staff availability and support are increasing satisfaction with working conditions in organizations. While female farmers are targeting more by the public and consultants, educated farmers are more prioritized in firms, dealers, and consultations. The internalization of innovative values is lower in the public organizations compared to the others. It is foreseen that; the public will carry out extension in developing countries for a long time. The success in extension organizations, the innovation process and pluralistic structure became quite more dependent on the relations with the private sector, domestic and international market mechanisms, demand driven giving advice and government policies on social, economic, and environmental. ABSTRACT activities goal investigated 96 firms results 80 economically lowest workers skills ideas creativity authorityresponsibility authority responsibility harmony freedom consultants consultations others time mechanisms social economic environmental 9 8

SUMMARY OBJECTIVE: Cellular and humoral immunity plays a role in the pathogenesis of vitiligo. T lymphocytes and natural killer cells involved in cellular immunity carry out their cytotoxic activities through perforin/granzyme-dependent granule exocytosis, in which granulysin and cathepsin-L are also involved. The aim of this study was to investigate the possible role of serum granulysin and cathepsin-L in the etiopathogenesis of vitiligo and their association with disease activity and severity. METHODS: This randomized, prospective case-control study was conducted with 46 vitiligo patients admitted to the hospital for vitiligo between January and November 2021 and 46 healthy volunteers of similar age and gender. Serum levels of granulysin and cathepsin-L were measured by the enzyme-linked immunosorbent assay method. RESULTS: The mean serum levels of granulysin and cathepsin-L were statistically significantly higher in vitiligo patients compared with the control group (p=0.048 and p=0.024, respectively). There was no statistically significant correlation between serum granulysin and serum cathepsin-L levels and disease severity in the patient group (r=0.30, p=0.062 and r=0.268, p=0.071, respectively). Disease activity also showed no significant association with serum granulysin and cathepsin-L levels (p=0.986 and p=0.962, respectively). CONCLUSION: Although granulysin and cathepsin-L are molecules involved in the pathogenesis of vitiligo, the use of these molecules may not be helpful in assessing disease activity and severity. It may be helpful to conduct comprehensive and prospective studies to find new molecules to fill the gap in this area. OBJECTIVE perforin/granzymedependent perforingranzymedependent perforin/granzyme dependent perforin granzyme exocytosis cathepsinL cathepsin L METHODS randomized casecontrol case 4 202 gender enzymelinked enzyme linked method RESULTS p=0.048 p0048 p 0 048 (p=0.04 p0024 024 p=0.024 respectively. respectively . respectively) r=0.30, r030 r 30 (r=0.30 p0062 062 p=0.06 r0268 268 r=0.268 p0071 071 p=0.071 p=0.986 p0986 986 (p=0.98 p0962 962 p=0.962 CONCLUSION area granzymedependent perforingranzyme 20 p=0.04 p004 04 (p=0.0 p002 02 p=0.02 r=0.30 r03 3 (r=0.3 p006 06 p=0.0 r026 26 r=0.26 p007 07 p=0.07 p=0.98 p098 98 (p=0.9 p096 96 p=0.96 2 p00 (p=0. r=0.3 r0 (r=0. p=0. r02 r=0.2 p=0.9 p09 9 p0 (p=0 r=0. (r=0 p=0 (p= r=0 (r= p= (p r= (r

Abstract The current research intended to examine the impact of dietary lemon peel powder (LPP) on laying quail performance, egg quality criteria, and the antioxidant capacity of the yolk. A total of 120 female Japanese quails (272.6±9.3 g), aged 21 weeks, were allotted to 6 trial groups, each with 5 replicates of 4 quails. Additions of 0, 1, 2, 3, 4, or 5 g/kg of LPP to the basal diet were used to create the treatment groups. Quails were fed ad libitum for 70 days. Neither performance parameters nor egg production was affected by LPP. However, eggshell-breaking strength improved by adding 2 g/kg LPP to the diet, but worsened at 5 g/kg. Moreover, the relative weight of eggshell and yolk L* value decreased with the treatments. Dietary LPP enhanced oxidative stability, reducing malondialdehyde (MDA) and increasing 1,1-diphenyl-2-picrylhydrazyl (DPPH) yolk values. The current study demonstrated that LPP, a safe and easily accessible agricultural by-product, enhanced eggshell quality when it was included in the diet of laying quails at doses of 2 g/kg. In contrast, improvement of yolk antioxidant capacity required increased amounts of LPP (4 g/kg). LPP could be advantageous to animal nutrition as an adequate substitute to reduce waste by-products (LPP criteria 12 272.6±9.3 272693 272 9 3 (272.6±9. g, g , g) weeks groups 0 1 gkg kg 7 days However eggshellbreaking breaking Moreover L treatments stability MDA (MDA 1,1diphenyl2picrylhydrazyl 11diphenyl2picrylhydrazyl diphenylpicrylhydrazyl 1,1 diphenyl picrylhydrazyl DPPH (DPPH values byproduct, byproduct product, product by-product contrast ( . g/kg) byproducts products 272.6±9. 27269 27 (272.6±9 1diphenyl2picrylhydrazyl 11 272.6±9 2726 (272.6± 272.6± (272.6 272.6 (272. 272. (272 (27 (2

RESUMO Objetivo: Este estudo foi conduzido para determinar a relação entre a não aderência à restrição alimentar e hídrica, o índice de massa corporal e a severidade da fadiga em pacientes recebendo diálise. Método: Foi realizado um estudo descritivo e transversal com 42 pacientes recebendo diálise. Os dados foram coletados empregando o “Formulário de informações gerais”, Índice de Massa Corporal, “Escala de Severidade da Fadiga” e “Dieta da Diálise e Escala de Incompatibilidade Hídrica”. Os dados foram avaliados usando porcentagens, médias, ANOVA unidirecional, testes T e testes de correlação de Pearson. Resultados: O número médio de dias que os pacientes não cumpriram os requisitos da dieta foi de 3,69 ± 4,85 e o número médio de dias que não cumpriram os requisitos da restrição hídrica foi de 2,71 ± 5,02. Foi constatado que a idade e o estado civil dos pacientes afetavam a severidade da fadiga. Foi constatado que os casos estavam associados aos valores de creatinina e cálcio e ao número de dias que não cumpriam os requisitos da restrição hídrica. Conclusão: Foi determinado que não houve relação significativa entre o não cumprimento dos requisitos da dieta e da restrição hídrica e a severidade da fadiga. Foi constatado que a severidade da fadiga foi menor nos pacientes que cumpriram os requisitos da dieta e restrição hídrica, embora não significativamente menor em comparação àqueles que não cumpriram. Objetivo diálise Método 4 Formulário gerais, gerais , gerais” Corporal Fadiga Dieta Hídrica. Hídrica . Hídrica” porcentagens médias unidirecional Pearson Resultados 369 3 69 3,6 485 85 4,8 271 2 71 2,7 502 5 02 5,02 Conclusão 36 6 3, 48 8 4, 27 7 2, 50 0 5,0 5,

ABSTRACT Objective: This study was conducted to determine the relationship between non-compliance with dietary and fluid restriction, body mass index, and the severity of fatigue in dialysis patients. Method: A descriptive and cross-sectional study was conducted on 42 dialysis patients. The data were collected employing a “General Information Form”, Body Mass Index, “Fatigue Severity Scale”, and “Dialysis Diet and Fluid Non-Adherence Questionnaire.”. Data were evaluated using percentages, averages, one-way ANOVA, T-tests, and Pearson correlation tests. Results: The average number of days when the patients did not comply with their diet was 3.69 ± 4.85, and the average number of days when they did not comply with fluid restriction was 2.71 ± 5.02. The age and marital status of the patients were found to affect the fatigue severity. It was found that the cases were associated with creatinine and calcium values and the number of days they did not comply with fluid restriction. Conclusion: It was determined that there was no significant relationship between non-compliance with diet and fluid restriction and the severity of fatigue. It was found that the severity of fatigue was lower in patients who complied with diet and fluid restriction, although not significantly lower than in those who did not comply. Objective noncompliance non compliance index Method crosssectional cross sectional 4 General Form, Form , Form” Index Fatigue Scale, Scale Scale” Dialysis NonAdherence Non Adherence Questionnaire.. Questionnaire Questionnaire. . Questionnaire.” percentages averages oneway one way ANOVA Ttests, Ttests T tests, tests T-tests Results 369 3 69 3.6 485 85 4.85 271 2 71 2.7 502 5 02 5.02 Conclusion 36 6 3. 48 8 4.8 27 7 2. 50 0 5.0 4. 5.

RESUMEN Objetivo: Este estudio se realizó para determinar la relación entre el incumplimiento de la restricción dietética y de líquidos, el índice de masa corporal y la gravedad de la fatiga en pacientes en diálisis. Método: Se realizó un estudio descriptivo y transversal sobre 42 pacientes en diálisis. Los datos fueron recolectados mediante el “Formulario de información general”, Índice de Masa Corporal, “Escala de gravedad de la fatiga” y “Escala de incompatibilidad de líquidos y dieta de diálisis”. Los datos se evaluaron utilizando porcentajes, promedios, unidireccional ANOVA, Pruebas T y pruebas de correlación de Pearson. Resultados: El promedio de días que los pacientes no cumplieron con su dieta fue de 3,69 ± 4,85, y el promedio de días que no cumplieron con la restricción de líquidos fue de 2,71 ± 5,02. Se descubrió que la edad y el estado civil de los pacientes afectan la gravedad de la fatiga. Se encontró que los casos estuvieron asociados con los valores de creatinina y calcio y el número de días que no cumplieron con la restricción de líquidos. Conclusión: Se determinó que no existía una relación significativa entre el incumplimiento de la dieta y la restricción de líquidos y la gravedad de la fatiga. Se encontró que la gravedad de la fatiga era menor en los pacientes que cumplían con la dieta y la restricción de líquidos, aunque no significativamente menor que en aquellos que no la cumplían. Objetivo diálisis Método 4 Formulario general, general , general” Corporal Escala . diálisis” porcentajes promedios ANOVA Pearson Resultados 369 3 69 3,6 485 85 4,85 271 2 71 2,7 502 5 02 5,02 Conclusión 36 6 3, 48 8 4,8 27 7 2, 50 0 5,0 4, 5,

RESUMO Objetivo Analisar o impacto do período pandêmico na vida saudável, na nutrição e nos estados de ansiedade do pessoal acadêmico universitário. Métodos Estudo transversal com amostra probabilística de 507 acadêmicos da Bursa Uludag University, Turquia. As alterações nas quantidades de consumo de alimentos e bebidas, e no estilo de vida foram determinadas através de um questionário elaborado, e os estados de ansiedade foram determinados através do Inventário de Ansiedade de Beck. As análises estatísticas do estudo foram realizadas no programa IBM®SPSS® 23.0. O teste Qui-quadrado de Pearson, correção de Yates e o teste exato de Fisher foram utilizados para comparação das variáveis. Resultados Durante a pandemia, a taxa de alimentação e o uso de vitaminas e minerais adicionais foram significativamente maiores nas mulheres (p=0.03, p<0.001, respectivamente). Durante o período pandêmico, os participantes do sexo masculino consumiram mais peixe do que as mulheres (p=0.037), e as mulheres consumiram mais café do que os homens durante esse período (p=0.004). Em comparação com o período pré-pandemia, o número de pessoas que tomam regularmente o café da manhã aumentou, enquanto o número de pessoas que almoçam e jantam regularmente diminuiu. Foi determinado que à medida que o escore BAI aumentava, a duração do sono diminuía gradativamente (p=0.001), o consumo de alimentos enlatados e o uso de alimentos para viagem aumentavam (p=0.011, p=0.001, respectivamente). Afirmou-se que o peso dos participantes aumentou, exceto aqueles com ansiedade mínima. Conclusão Verificou-se que a maioria dos participantes tendeu a consumir mais alimentos durante o período pandêmico. Observou-se que o índice de quem engordou durante a pandemia foi maior. Apesar disso, constatou-se que escolhas mais saudáveis são feitas à medida que aumenta o consumo de alguns alimentos. O nível de ansiedade foi considerado mais positivo do que alguns estudos semelhantes. O nível de escolaridade pode ter um efeito parcial na escolha de alimentos saudáveis e no enfrentamento da ansiedade. saudável universitário 50 University Turquia bebidas elaborado Beck IBMSPSS IBM SPSS IBM®SPSS 230 23 0 23.0 Quiquadrado Qui quadrado Pearson variáveis p=0.03, p003 p 03 (p=0.03 p0001 001 p<0.001 respectivamente. respectivamente . respectivamente) p=0.037, p0037 p=0.037 , 037 (p=0.037) p=0.004. p0004 p=0.004 004 (p=0.004) prépandemia, prépandemia pré pré-pandemia aumentou diminuiu aumentava p=0.001 (p=0.001) p=0.011, p0011 011 (p=0.011 Afirmouse Afirmou se mínima Verificouse Verificou Observouse Observou maior disso constatouse constatou semelhantes 5 2 23. p=0.03 p00 (p=0.0 p000 00 p<0.00 (p=0.037 p=0.00 (p=0.004 (p=0.001 p=0.011 p001 01 (p=0.01 p=0.0 p0 (p=0. p<0.0 (p=0.00 p=0.01 p=0. (p=0 p<0. p=0 (p= p<0 p= (p p<

ABSTRACT Objective Analyze the impact of the pandemic period on the healthy living, nutrition and anxiety states of university academic personnel. Methods Cross-sectional study with a probabilistic sample of 507 academic personnel from Bursa Uludag University, Bursa, Türkiye. Changes in consumption amounts of food and beverages and lifestyle were determined through a prepared questionnaire, and anxiety states were determined through the Beck Anxiety Inventory. Statistical analyses of the study were performed with IBM®SPSS® 23.0 program. The Pearson Chi-square test, Yates correction, and Fisher’s exact test were used to compare variables. Results During the pandemic, the rate of eating and the use of additional vitamins and minerals were significantly higher in women (p=0.03, p<0.001, respectively). In the pandemic period, male participants consumed more fish than women (p=0.037), and women consumed more coffee than men during this period (p=0.004). Compared to the pre-pandemic period, those who regularly eat breakfast have increased, while those who regularly eat lunch and dinner have decreased. It was determined that as the BAI score increased, the sleep duration gradually decreased (p=0.001), and the consumption of canned food and the use of takeaway food increased (p=0.011, p=0.001, respectively). It was stated that the weight of the participants increased, except for those with minimal anxiety. Conclusion It was found that most of the participants tended to consume more food during the pandemic period. It was observed that the rate of those who gained weight during the pandemic was higher. Despite this, it has been determined that healthier choices are made as the consumption of some food increases. The level of anxiety was found to be more positive than in some similar studies. Education level may have a partial effect on choosing healthy food and coping with anxiety. living Crosssectional Cross sectional 50 University Türkiye questionnaire Inventory IBMSPSS IBM SPSS IBM®SPSS 230 23 0 23. program Chisquare Chi square correction Fishers Fisher s variables p=0.03, p003 p 03 (p=0.03 p0001 001 p<0.001 respectively. respectively . respectively) p=0.037, p0037 p=0.037 , 037 (p=0.037) p=0.004. p0004 p=0.004 004 (p=0.004) prepandemic pre p=0.001 (p=0.001) p=0.011, p0011 011 (p=0.011 increases studies 5 2 p=0.03 p00 (p=0.0 p000 00 p<0.00 (p=0.037 p=0.00 (p=0.004 (p=0.001 p=0.011 p001 01 (p=0.01 p=0.0 p0 (p=0. p<0.0 (p=0.00 p=0.01 p=0. (p=0 p<0. p=0 (p= p<0 p= (p p<

SUMMARY AIM: The aim of the study was to determine the respiratory muscle strength of stroke patients and compare them with healthy individuals. METHOD: The study was conducted with 171 patients who had a stroke between 2017 and 2021 and 32 healthy controls. Respiratory muscle strength and inspiratory and expiratory mouth pressure (MIP and MEP) were measured using the portable MicroRPM device (Micro Medical, Basingstoke, UK). RESULTS: The stroke group exhibited significantly lower values in both MIP for men (p<0.001) and women (p=0.013) and maximal expiratory pressure for men (p<0.001) and women (p=0.042), compared with the healthy control group. Notably, there was a significant difference in the MIPmen (p=0.026) and MEPmen (p=0.026) values when comparing the reference values, which were calculated based on age and sex, with those of the healthy group. The baseline values calculated according to age for stroke patients were as follows: MIPmen 31.68%, MIPwomen 63.58%, MEPmen 22.54%, and MEPwomen 42.30%. CONCLUSION: This study highlights the significant respiratory muscle weakness experienced by stroke patients, with gender-specific differences. It highlights the importance of incorporating respiratory assessments and interventions into stroke rehabilitation protocols to improve the overall health and well-being of stroke patients. AIM individuals METHOD 17 201 202 3 controls MEP Micro Medical Basingstoke UK. UK . UK) RESULTS p<0.001 p0001 p 0 001 (p<0.001 p=0.013 p0013 013 (p=0.013 p=0.042, p0042 p=0.042 , 042 (p=0.042) Notably p=0.026 p0026 026 (p=0.026 sex follows 3168 31 68 31.68% 6358 63 58 63.58% 2254 22 54 22.54% 4230 42 30 42.30% CONCLUSION genderspecific gender specific differences wellbeing well being 1 20 p<0.00 p000 00 (p<0.00 p=0.01 p001 01 (p=0.01 p004 p=0.04 04 (p=0.042 p=0.02 p002 02 (p=0.02 316 6 31.68 635 5 63.58 225 2 22.54 423 4 42.30 p<0.0 p00 (p<0.0 p=0.0 (p=0.0 (p=0.04 31.6 63.5 22.5 42.3 p<0. p0 (p<0. p=0. (p=0. 31. 63. 22. 42. p<0 (p<0 p=0 (p=0 p< (p< p= (p= (p

SUMMARY OBJECTIVE: This systematic review and meta-analysis aimed to investigate the effects of herbal treatments on cervicovaginal human papillomavirus infection. METHODS: A comprehensive literature search was conducted in PubMed, Scopus, Science Direct, and the Cochrane Library until December 2023, following Cochrane guidelines. Data were analyzed using the Review Manager computer program (Version 5.4.1). RESULTS: Five randomized controlled trials involving a total sample size of 662 women were included in the study. The pooled odds ratio for individuals testing negative for human papillomavirus after herbal intervention among human papillomavirus-positive patients was 1.86 (95% confidence interval (CI) 0.64–5.43), according to the fixed-effects model. Three out of the five studies indicated a significant relationship. The relationship between positive human papillomavirus infection and herbal treatments, measured by the fixed-effects model, resulted in a pooled odds ratio of 0.41 (95%CI 0.17–1.01), reporting a significant association (p=0.05). Subgroup analysis revealed a significant reduction in the relationship between herbal treatment and atypical squamous cells of undetermined significance (OR 0.16, 95%CI 0.03–0.88, p=0.04) but no significant impact on the relationship between herbal treatment and low-grade squamous intraepithelial lesion (OR 0.33, 95%CI 0.01–8.77, p=0.51). CONCLUSION: The meta-analysis suggests that herbal treatments reduce human papillomavirus infections. While herbal treatments show a significant reduction in atypical squamous cells of undetermined significance, they do not significantly impact the regression of low-grade squamous intraepithelial lesions. OBJECTIVE metaanalysis meta METHODS PubMed Scopus Direct 2023 guidelines Version 5.4.1. 541 5.4.1 . 5 4 1 5.4.1) RESULTS 66 study papillomaviruspositive 186 86 1.8 95% 95 (95 CI (CI 0.64–5.43, 064543 0.64–5.43 , 0 64 43 0.64–5.43) fixedeffects fixed model 041 41 0.4 95CI 0.17–1.01, 017101 0.17–1.01 17 01 0.17–1.01) p=0.05. p005 p p=0.05 05 (p=0.05) OR 016 16 0.16 003088 03 88 0.03–0.88 p=0.04 p004 04 lowgrade low grade 033 33 0.33 001877 8 77 0.01–8.77 p=0.51. p051 p=0.51 51 p=0.51) CONCLUSION infections lesions 202 54 5.4. 6 18 1. 9 (9 06454 0.64–5.4 0. 01710 0.17–1.0 p00 p=0.0 (p=0.05 0.1 00308 0.03–0.8 3 0.3 00187 7 0.01–8.7 p05 p=0.5 20 5.4 ( 0645 0.64–5. 0171 0.17–1. p0 p=0. (p=0.0 0030 0.03–0. 0018 0.01–8. 2 5. 064 0.64–5 017 0.17–1 p=0 (p=0. 003 0.03–0 001 0.01–8 06 0.64– 0.17– p= (p=0 00 0.03– 0.01– 0.64 0.17 (p= 0.03 0.01 0.6 (p 0.0

RESUMO Objetivo A síndrome metabólica é uma doença endócrina comum em todo o mundo. Medidas antropométricas e índices relacionados à obesidade podem ser utilizados de forma eficaz no diagnóstico. Este estudo investiga o uso de índices relacionados à obesidade na definição da síndrome metabólica. Métodos Analisamos os dados transversais de 2.720 indivíduos, jovens e de meia-idade. Utilizamos índice de forma corporal A, índice de volume abdominal, índice de adiposidade corporal, índice de redondeza corporal, índice de conicidade, Produto de acúmulo de lipídios, índice de adiposidade visceral, foi avaliado o índice de triglicerídeos Cintura. E também foi realizada uma análise receiver operating characteristic. Resultados Os valores de odds ratio e intervalo de confiança de 95% (IC 95%) para o risco de síndrome metabólica foram 1,035 (1,021-1,049) no índice de triglicerídeos cintura, 1,045 (1,012-1,079) no índice de adiposidade corporal (p0,05), 1,084 (1,051- 1,119) no produto de acúmulo de lipídios, 5,789 (4,536-7,388) no índice de adiposidade visceral (p0,001). Conclusão Concluiu-se que índice de triglicerídeos cinturas, índice de adiposidade corporal, produto de acúmulo de lipídios, índice de adiposidade visceral pode ser utilizados como alternativa para identificação de síndrome metabólica em adultos. Foram encontrados valores de corte dos índices índice de triglicerídeos cinturas, produto de acúmulo de lipídios e índice de adiposidade visceral para a presença de síndrome metabólica. mundo diagnóstico 2720 2 720 2.72 indivíduos meiaidade. meiaidade meia idade. idade meia-idade abdominal conicidade Cintura characteristic 95 IC 1035 1 035 1,03 1,0211,049 10211049 1,021 1,049 021 049 (1,021-1,049 cintura 1045 045 1,04 1,0121,079 10121079 1,012 1,079 012 079 (1,012-1,079 p0,05, p005 p p0,05 , p0 05 (p0,05) 1084 084 1,08 1,051 1051 051 (1,051 1,119 1119 119 5789 5 789 5,78 4,5367,388 45367388 4,536 7,388 4 536 7 388 (4,536-7,388 p0,001. p0001 p0,001 . 001 (p0,001) Concluiuse Concluiu se cinturas adultos 272 72 2.7 9 103 03 1,0 0211 1,0211,04 1021104 1021 1,02 1049 02 04 (1,021-1,04 104 0121 1,0121,07 1012107 1012 1,01 1079 1,07 01 07 (1,012-1,07 p00 p0,0 0 (p0,05 108 08 1,05 105 (1,05 1,11 111 11 578 78 5,7 5367 4,5367,38 4536738 4536 4,53 7388 7,38 53 38 (4,536-7,38 p000 p0,00 00 (p0,001 27 2. 10 1, 1,0211,0 102110 102 (1,021-1,0 1,0121,0 101210 101 107 (1,012-1,0 p0, (p0,0 (1,0 1,1 57 5, 4,5367,3 453673 453 4,5 738 7,3 3 (4,536-7,3 (p0,00 1,0211, 10211 (1,021-1, 1,0121, 10121 (1,012-1, (p0, (1, 4,5367, 45367 45 4, 73 7, (4,536-7, 1,0211 (1,021-1 1,0121 (1,012-1 (p0 (1 4,5367 (4,536-7 (1,021- (1,012- (p ( (4,536- (1,021 (1,012 (4,536 (1,02 (1,01 (4,53 (4,5 (4, (4

ABSTRACT Objective Metabolic syndrome is common endocrine disease worldwide. Anthropometric measurements and obesity-related indices can be used effectively in its diagnosis. This study investigates the use of obesity-related indices in defining metabolic syndrome. Methods Cross-sectional data from 2,720 young and middle-aged individuals were analyzed. A body shape index, abdominal volume index, body adiposity index, body roundness index, conicity index, lipid accumulation product, visceral adiposity index, and waist-triglyceride index were evaluated. Receiver operating characteristic analysis was performed. Results The odds ratio and 95% confidence interval (95% CI) values for the risk of metabolic syndrome were 1.035 (1.021-1.049) for waist-triglyceride index, 1.045 (1.012-1.079) for body adiposity index (p0.05), 1.084 (1.051-1.119) for lipid accumulation product, and 5.789 (4.536-7.388) for visceral adiposity index (No-BreakpNo-Break0.001). Conclusion It was concluded that waist-triglyceride index, body adiposity index, lipid accumulation product, and visceral adiposity index can be used as alternatives for identifying metabolic syndrome in adults. Cut-off values for waist-triglyceride index, lipid accumulation product, and visceral adiposity index indices were found for the presence of metabolic syndrome. worldwide obesityrelated obesity related diagnosis Crosssectional Cross sectional 2720 2 720 2,72 middleaged middle aged analyzed product waisttriglyceride waist triglyceride evaluated performed 95 (95 CI 1035 1 035 1.03 1.0211.049 10211049 1.021 1.049 021 049 (1.021-1.049 1045 045 1.04 1.0121.079 10121079 1.012 1.079 012 079 (1.012-1.079 p0.05, p005 p p0.05 , p0 05 (p0.05) 1084 084 1.08 1.0511.119 10511119 1.051 1.119 051 119 (1.051-1.119 5789 5 789 5.78 4.5367.388 45367388 4.536 7.388 4 536 7 388 (4.536-7.388 NoBreakpNoBreak0.001. NoBreakpNoBreak0001 NoBreakpNoBreak No BreakpNo Break0.001 . Break0 001 Break (No-BreakpNo-Break0.001) adults Cutoff Cut off 272 72 2,7 9 (9 103 03 1.0 0211 1.0211.04 1021104 1021 1.02 1049 02 04 (1.021-1.04 104 0121 1.0121.07 1012107 1012 1.01 1079 1.07 01 07 (1.012-1.07 p00 p0.0 0 (p0.05 108 08 0511 1.0511.11 1051111 1051 1.05 1119 1.11 11 (1.051-1.11 578 78 5.7 5367 4.5367.38 4536738 4536 4.53 7388 7.38 53 38 (4.536-7.38 NoBreakpNoBreak0 NoBreakpNoBreak0.001 NoBreakpNoBreak000 Break0001 Break0.00 00 (No-BreakpNo-Break0.001 27 2, ( 10 1. 1.0211.0 102110 102 (1.021-1.0 1.0121.0 101210 101 107 (1.012-1.0 p0. (p0.0 1.0511.1 105111 105 111 1.1 (1.051-1.1 57 5. 4.5367.3 453673 453 4.5 738 7.3 3 (4.536-7.3 NoBreakpNoBreak0.00 NoBreakpNoBreak00 Break000 Break0.0 (No-BreakpNo-Break0.00 1.0211. 10211 (1.021-1. 1.0121. 10121 (1.012-1. (p0. 1.0511. 10511 (1.051-1. 4.5367. 45367 45 4. 73 7. (4.536-7. NoBreakpNoBreak0.0 Break00 Break0. (No-BreakpNo-Break0.0 1.0211 (1.021-1 1.0121 (1.012-1 (p0 1.0511 (1.051-1 4.5367 (4.536-7 NoBreakpNoBreak0. (No-BreakpNo-Break0. (1.021- (1.012- (p (1.051- (4.536- (No-BreakpNo-Break0 (1.021 (1.012 (1.051 (4.536 (No-BreakpNo-Break (1.02 (1.01 (1.05 (4.53 (1.0 (4.5 (1. (4. (1 (4

SUMMARY OBJECTIVE: Endometriosis is a disease in which stromal cells and endometrial glands extend outside of the uterine cavity. Nevertheless, treatment failure and recurrence cause difficulties in management. This study aimed to evaluate the receptor-level components of bilateral endometriomas in the recurrence state. METHODS: Our retrospective cohort study was conducted with patients who underwent surgery for bilateral endometriomas between 2015 and 2021. In total, 113 patients were allocated. A total of 76 patients did not meet the eligibility criteria, and the data of 37 patients were evaluated. Medical treatments, recurrences, and postoperative follow-up data were collected. In archived tissue samples, measurements of progesterone receptor A and progesterone receptor B, histoscores and immunoreactivity scores, and their ratios were calculated in the group that received no postoperative medical treatment. Criteria for recurrence were a repeat operation and/or the detection of a new endometrioma>2 cm at the follow-up examination. RESULTS: No recurrence was observed in 73.0% (n=27) of the cases, whereas recurrence was observed in 27.0% (n=10) of the participants. Patients without recurrence had significantly higher progesterone receptor B histoscore/progesterone receptor A histoscore and progesterone receptor B immunoreactivity score/progesterone receptor A immunoreactivity score results (p=0.01). Nevertheless, when the histoscores and immunoreactivity scores for both receptors were contrasted separately, there was no appreciable difference between them. CONCLUSION: The dominance of progesterone receptor B over progesterone receptor A was inversely proportional to the recurrence status in bilateral endometriomas. Furthermore, our study revealed that assessing receptor levels alone did not result in a significant difference in recurrence. OBJECTIVE cavity Nevertheless management receptorlevel level state METHODS 201 2021 11 allocated 7 criteria 3 evaluated treatments recurrences followup follow up collected samples andor or endometrioma2 endometrioma 2 endometrioma> examination RESULTS 730 73 0 73.0 n=27 n27 n 27 (n=27 cases 270 27.0 n=10 n10 10 (n=10 participants histoscoreprogesterone scoreprogesterone p=0.01. p001 p p=0.01 . 01 (p=0.01) separately them CONCLUSION Furthermore 20 202 1 73. n=2 n2 (n=2 27. n=1 n1 (n=1 p00 p=0.0 (p=0.01 n= (n= p0 p=0. (p=0.0 (n p=0 (p=0. p= (p=0 (p= (p

SUMMARY OBJECTIVE: The objective of this study was to describe the single-surgeon experience on transvaginal natural orifice transluminal endoscopic surgery for uterosacral ligament suspension in patients with severe prolapse who had concomitant vaginal hysterectomy. METHODS: A total of 53 patients with severe uterine prolapse who underwent vaginal hysterectomy and transvaginal natural orifice transluminal endoscopic surgery for uterosacral ligament suspension between January 2021 and March 2023 were included in the study. Operation time, intraoperative and postoperative complications, de novo urinary continence, and duration of hospitalization were obtained from the patient records. Initial postoperative follow-up visits were scheduled for the first week of the month. Patients were followed up yearly, and they had the opportunity to reach the surgical team at any time. Symptomatic prolapse beyond the hymen is defined as recurrence. RESULTS: Patients had a mean age of 61.7 years ±7.7 SD. All patients received bilateral opportunistic salpingectomy and salpingo-oophorectomy. The total operation time was 162±31 min, with transvaginal natural orifice transluminal endoscopic surgery taking 32.3±5.37 min. There were no intraoperative complications. 12 patients had recurrence; 8 anterior, 3 apical, and 1 posterior prolapse. The mean recurrence time was 11.5 months (range 5–23 months). The reoperation rate was 13.2% (n:7). Three of the patients had obliterative vaginal surgery, three of the patients had anterior, and one patient had posterior repair. Overall failure of apical surgical procedure was 5.6%. Two patients had de novo incontinence postoperatively. CONCLUSIONS: Transvaginal natural orifice transluminal endoscopic surgery uterosacral ligament suspension is a feasible technique to treat severe pelvic organ prolapse with promising results for short-term efficacy and safety in patients who had concomitant vaginal hysterectomy. Longer follow-up periods are needed to evaluate the long-term efficacy profile of transvaginal natural orifice transluminal endoscopic surgery for uterosacral ligament suspension. OBJECTIVE singlesurgeon single surgeon METHODS 5 202 complications continence records followup follow month yearly RESULTS 617 61 7 61. 77 ±7. SD salpingooophorectomy. salpingooophorectomy salpingo oophorectomy. oophorectomy salpingo-oophorectomy 16231 162 31 162±3 min 323537 32 37 32.3±5.3 anterior 115 11 11. range 523 23 5–2 months. . months) 132 13 2 13.2 n7. n7 n (n:7) repair 56 6 5.6% postoperatively CONCLUSIONS shortterm short term longterm long 20 ±7 1623 16 162± 32353 32.3±5. 52 5– 13. (n:7 5.6 ± 3235 32.3±5 (n: 5. 323 32.3± (n 32.3 32.

Abstract Objective: This study was carried out to investigate the effect of autologous platelet-rich plasma (PRP) on intra-abdominal adhesion at the cesarean section incision line in the uterus. Material and methods: As experimental animals 16 white New Zealand rabbits, 5-months-old, unmated, were used. Animals were divided into two groups the control group and PRP application group. In each group, a transverse incision was made to the uterus to mimic the cesarean section and sutured. Relaparotomy was performed 21 days after the first operation. Results: When the groups were evaluated in terms of inflammation, there was a significant difference between the two groups. When the groups were evaluated in terms of Mason’s Trichrome staining and fibrosis, There was a significant difference between groups. When the groups were evaluated in terms of vascular endothelial growth factor-1, there was also a significant difference between the groups. In an experimental rabbit uterine horn adhesion model, PRP is effective in preventing post-operative adhesion formation. Conclusions: This result may guide clinical studies using autologous PRP to prevent post-operative adhesion formation after gynecological operations.

Resumen Objetivo: Este estudio se llevó a cabo para investigar el efecto del plasma rico en plaquetas (PRP) autólogo sobre la adhesión intraabdominal en la línea de incisión de la cesárea en el útero. Material y métodos: Como animales de experimentación se utilizaron 16 conejos blancos de Nueva Zelanda, de 5 meses de edad, sin aparear. Los animales se dividieron en dos grupos como grupo de control y grupo de aplicación de PRP. En cada grupo, se hizo una incisión transversal al útero para imitar la cesárea y se suturó. La relaparotomía se realizó 21 días después de la primera operación. Resultados: Cuando los grupos se evaluaron en términos de inflamación, hubo una diferencia significativa entre los dos grupos. Cuando los grupos se evaluaron en términos de tinción MT y fibrosis, hubo una diferencia significativa entre los grupos. Cuando los grupos se evaluaron en términos de VEGF-1, también hubo una diferencia significativa entre los grupos. En un modelo experimental de adherencia al cuerno uterino de conejo, el PRP es eficaz para prevenir la formación de adherencias posoperatorias. Conclusiones: Este resultado puede guiar los estudios clínicos que utilizan PRP autólogo para prevenir la formación de adherencias postoperatorias después de operaciones ginecológicas.

RESUMO Objetivo: Examinar a eficácia da ceratectomia fototerapêutica para o tratamento de patologias variáveis que apresentarem opacidades anteriores da córnea, e avaliar a distribuição das indicações de ceratectomia fototerapêutica nos últimos 10 anos. Métodos: Foram revisados retrospectivamente os prontuários de 276 pacientes, com 334 olhos tratados com ceratectomia fototerapêutica entre março de 2010 e o ano de 2020. As etiologias dos pacientes submetidos à ceratectomia fototerapêutica foram anotadas e suas alterações foram examinadas. Os resultados refrativos e de acuidade visual antes e após a operação foram registrados e analisados de acordo com a etiologia. Resultados: A idade média dos pacientes foi de 40,7 ± 16,2 anos (faixa: 19-84). O tempo médio de acompanhamento foi de 25,5 ± 19,1 meses (faixa: 3-96). A ceratectomia fototerapêutica foi aplicada com mais frequência para distrofias estromais corneanas (44%, 151 olhos de 111 pacientes); entre as distrofias corneanas como um todo, a distrofia granular foi a indicação terapêutica mais comum desse procedimento. Ao contrário de outras indicações, nos últimos 10 anos houve um aumento na aplicação de ceratectomia fototerapêutica em casos de opacidade subepitelial persistente causada por conjuntivite adenoviral. Houve um aumento significativo na acuidade visual em todos os grupos, exceto para o grupo com defeito epitelial recorrente (p<0,05). A maior melhora na acuidade visual foi detectada em casos de distrofia estromal, no subgrupo das distrofias granulares. Conclusão: Apesar das mudanças nas tendências de indicação, a ceratectomia fototerapêutica continua sendo uma abordagem terapêutica eficaz e confiável para tratar lesões da córnea anterior. Objetivo 1 Métodos 27 33 201 2020 examinadas etiologia Resultados 407 40 7 40, 162 16 2 16, faixa (faixa 1984. 1984 19 84 . 19-84) 255 25 5 25, 191 19, 396. 396 3 96 3-96) 44%, 44 (44% 15 11 pacientes) todo procedimento adenoviral grupos p<0,05. p005 p p<0,05 0 05 (p<0,05) estromal granulares Conclusão anterior 20 202 4 198 8 19-84 39 9 3-96 44% (44 p00 p<0,0 (p<0,05 19-8 3-9 (4 p0 p<0, (p<0,0 19- 3- ( p<0 (p<0, p< (p<0 (p< (p

ABSTRACT Purpose: To examine the efficacy of phototherapeutic keratectomy as a treatment for variable pathologies with anterior corneal opacities and evaluate the distribution of phototherapeutic keratectomy indications over the past 10 years. Methods: The records of 334 eyes from 276 patients who underwent phototherapeutic keratectomy between March 2010 and 2020 were retrospectively reviewed. Etiologies of the patients who underwent phototherapeutic keratectomy were noted, and their changes were examined. Refractive and visual acuity results before and after the operation were recorded and analyzed according to etiology. Results: The mean age of the patients was 40.7 ± 16.2 years (range: 19-84). The mean follow-up was 25.5 ± 19.1 months (range: 3-96). Phototherapeutic keratectomy was most frequently applied for corneal stromal dystrophies (44%, 151 eyes from 111 patients), and granular dystrophy was the most common phototherapeutic keratectomy indication among corneal dystrophies. Unlike other indications, there has been an increase in the application of phototherapeutic keratectomy for persistent subepithelial opacities due to adenoviral conjunctivitis in the past 10 years. There was a significant increase in visual acuity in all groups except for the recurrent epithelial defect group (p<0.05). The greatest improvement in visual acuity was detected for stromal dystrophies in the granular dystrophy subgroup. Conclusion: Despite changing indication trends, phototherapeutic keratectomy remains an effective and reliable treatment for anterior corneal lesions. Purpose 1 Methods 33 27 201 202 reviewed noted examined etiology Results 407 40 7 40. 162 16 2 16. range (range 1984. 1984 19 84 . 19-84) followup follow up 255 25 5 25. 191 19. 396. 396 3 96 3-96) 44%, 44 (44% 15 11 patients, , patients) p<0.05. p005 p p<0.05 0 05 (p<0.05) subgroup Conclusion trends lesions 20 4 198 8 19-84 39 9 3-96 44% (44 p00 p<0.0 (p<0.05 19-8 3-9 (4 p0 p<0. (p<0.0 19- 3- ( p<0 (p<0. p< (p<0 (p< (p