RESUMO: Objetivou-se avaliar o efeito da suplementação dietética de glutamina e ácido glutâmico (Gln+Glu) sobre o desempenho, a morfometria intestinal e as características de carcaça de codornas de corte. Foram utilizadas 800 aves, distribuídas em delineamento inteiramente casualizado, com cinco tratamentos (0,0; 0,2; 0,4; 0,6 e 0,8% de suplementação de Gln+Glu) e oito repetições com 20 aves por unidade experimental. Na fase de um a 21 dias, constatou-se menor (P < 0,05) consumo de ração aos níveis de 0,6 e 0,8% de Gln+Glu e menor ganho de peso ao nível 0,8% de Gln+Glu em comparação ao tratamento controle; e, pela análise de regressão, excluindo-se o tratamento controle, houve efeito linear crescente (P < 0,05) para consumo de ração na fase 22 a 42 dias de idade. Para morfometria intestinal, a suplementação de Gln+Glu apenas favoreceu o desenvolvimento vilos do íleo (P < 0,05), conferindo-lhe maior altura aos níveis de 0,2; 0,6 e 0,8% de suplementação. As características de carcaça, cortes e vísceras comestíveis das aves aos 42 dias não foram afetadas (P > 0,05) pelos níveis de suplementação de Gln+Glu. Assim, a suplementação de glutamina e ácido glutâmico influenciou o desempenho e a morfometria intestinal de codornas de corte aos 21 dias de idade, promovendo redução do consumo de ração e do ganho, associado ao aumento morfométrico do íleo; por outro lado, o desempenho das aves e as suas características de carcaça aos 42 dias não foram afetados pela suplementação dos aminoácidos. RESUMO Objetivouse Objetivou se GlnGlu Gln Glu (Gln+Glu 80 casualizado 0,0 00 0 (0,0 0,2 02 2 0,4 04 4 06 6 0, 08 8 0,8 experimental constatouse constatou P 0,05 005 05 controle regressão excluindose excluindo idade 0,05, , conferindolhe conferindo lhe Assim lado aminoácidos (0, (0 (

ABSTRACT: This study evaluated the effect of dietary supplementation with glutamine and glutamic acid (Gln+Glu) on performance, intestinal morphometry, and carcass characteristics of broiler quails. Eight hundred birds were used, distributed in an entirely randomized design with 20 birds per experimental unit, and given five treatments (0.0; 0.2; 0.4; 0.6; and 0.8% Gln+Glu supplementation) with eight replicates. At 1-21 days of age, lower (P < 0.05) feed intake at 0.6 and 0.8% Gln+Glu supplementation and lower weight gain at 0.8% Gln+Glu supplementation compared to the control treatment were observed. By regression analysis, excluding the control treatment, there was an increasing linear effect (P < 0.05) for feed intake at 22 to 42 days of age. For intestinal morphometry, Gln+Glu supplementation only favored the villus development of the ileum (P < 0.05), giving it greater height at 0.2, 0.6, and 0.8% supplementation. Carcass characteristics, cuts, and edible viscera of the birds at 42 days were not affected (P > 0.05) by Gln+Glu supplementation levels. Thus, the glutamine and glutamic acid supplementation affected the performance and intestinal morphology of 21-d-old quails, decreasing feed intake and weight gain associated with the improvement of ileum morphology; conversely, performance and carcass characteristics at 42 days were not affected by amino acid supplementation. ABSTRACT GlnGlu Gln Glu (Gln+Glu morphometry quails used 2 unit 0.0 00 0 (0.0 0.2 02 0.4 04 4 06 6 08 8 0.8 replicates 121 1 21 1-2 age P 0.05 005 05 0. observed analysis 0.05, , cuts levels Thus 21dold dold d old conversely (0. 12 1- (0 (

ABSTRACT Sporotrichosis is caused by fungi belonging to the genus Sporothrix, and is generally acquired by traumatic inoculation. A 26-year-old man developed pustular lesions and a 6-kg weight loss after developing a lesion on his right hand 6 months previously. He was diagnosed with acquired human immunodeficiency syndrome (AIDS) and disseminated sporotrichosis cultures of bone and muscle biopsy and blood samples grew Sporothrix schenckii. The patient underwent reconstructive surgery and 9 months of treatment with amphotericin B and itraconazole, and showed complete wound healing and improved hand functionality. Suspicion of the disease is necessary in immunosuppressed patients living in endemic areas. inoculation 26yearold yearold 26 year old 6kg kg previously AIDS (AIDS schenckii itraconazole functionality areas 2

Resumo As Unidades de Conservação possuem uma grande importância para a estabilidade do meio ambiente, havendo possibilidade de uso sustentável, a exemplo das Áreas de Proteção Ambiental (APAs). Nessas áreas, a vegetação remanescente configura um importante componente no monitoramento e avaliação da fragilidade ambiental. Assim, este estudo objetivou avaliar a dinâmica espaço-temporal na APA da Marituba do Peixe (APA-MP), com fins de diagnosticar a fragilidade ambiental da vegetação remanescente. Foi utilizada imagem do satélite RapidEye, para o ano de 2011, disponíveis gratuitamente no site do Ministério do Meio Ambiente (GeoCatálogo) e imagem de satélite disponibilizada no software Google Earth, para o ano de 2020. A vegetação foi vetorizada, e determinadas as métricas da paisagem com o uso de SIG. Na APA-MP, em 2011, foram mapeados 108 fragmentos de vegetação remanescente, com área total de 3.314 ha e um índice médio de forma de 1,843±0,638. Já em 2020, os fragmentos de vegetação remanescentes reduziram a 89 manchas, somando uma área de 2.684 ha, com índice médio de forma de 1,906±0,664. O número, o tamanho dos fragmentos e o índice de forma evidenciam que a vegetação remanescente apresenta fragilidade ambiental. Houve supressão de vegetação ao longo dos anos nas diferentes zonas. Não houve quadro de recuperação ambiental em nenhuma das zonas de proteção da APA-MP. O cenário requer a implementação de ações para a promoção da recuperação ambiental.

Abstract Conservation Units are of great importance for the stability of the environment, allowing the possibility of sustainable use, such as Environmental Protection Areas (EPA). In these areas, the remaining vegetation is an important component in monitoring and assessing the environmental fragility. Thus, this study aimed to evaluate the spatio-temporal dynamics in the EPA of Marituba do Peixe (EPA-MP), with the purpose to diagnose the environmental fragility of the remaining vegetation. The research used an image of the RapidEye satellite for the year 2011 available for free on the Ministry of the Environment website (Geo Catalog), and a satellite image available in the Google Earth software for the year 2020. The vegetation was vectorized, and the landscape metrics were determined using GIS. In 2011, in EPA-MP, 108 fragments of remaining vegetation with an area of 3,314 ha were mapped, with an average shape index of 1.84±0.638. In 2020, the remaining vegetation fragments reduced to 89 patches, adding up to an area of 2,684ha, with an average shape index of 1.906±0.664. The results point out that the remaining vegetation presents environmental fragility, as shown by the number, the size of fragments, and the shape index. The vegetation suppression has been occurring over the years in the different zones. There was no picture of environmental recovery in any of the EPA-MP protection zones. The scenario requires the implementation of actions to promote the environmental recovery.

RESUMO Relatamos o caso de um paciente com evolução e diagnóstico tardios de cisto de íris no olho direito, provavelmente secundário a trauma, com complicações importantes e baixa irreversível da visão, tendo sido admitido no Hospital Universitário Antônio Pedro já com leucoma total da córnea e câmara anterior indevassável. A biomicroscopia ultrassônica se mostrou imprescindível para o estudo anatômico, sendo o paciente finalmente submetido à enucleação, para melhora estética e elucidação diagnóstica. Concluímos que a atalamia e a desestruturação do segmento anterior, consequentes ao crescimento cístico, levaram a um gradativo aumento da pressão intraocular e lesão do nervo óptico, com consequente perda da visão.

ABSTRACT The authors report the case of a male adult presenting significant ocular complications and irreversible visual impairment, resulting from the long-term progression and late diagnosis of an iris cyst in the right eye, probably secondary to trauma. The patient was admitted to Hospital Universitário Antonio Pedro with a total corneal opacity that blocked direct visualization of the anterior chamber. Ultrasound biomicroscopy was crucial for the anatomic study, and the patient was submitted to enucleation for aesthetic improvement and clarifying diagnosis. We concluded athalamia and deformation of the anterior segment, due to expansion of the cyst, led to gradual elevation of the intraocular pressure and damage of the optic nerve, resulting in visual loss.

ABSTRACT CONTEXT: Central nervous system (CNS) infectious diseases have high prevalence in developing countries and their proper diagnosis and treatment are very important for public health planning. Cryptococcus neoformans is a fungus that may cause several CNS manifestations, especially in immunocompromised patients. Cryptococcal meningitis is the most common type of involvement. Mass-effect lesions are uncommon: they are described as cryptococcomas and their prevalence is even lower among immunocompetent patients. The aim here was to report an extremely rare case of cryptococcoma causing a mass effect and mimicking a brain tumor in an immunocompetent patient. The literature on CNS cryptococcal infections was reviewed with emphasis on cryptococcomas. Clinical, surgical and radiological data on a female patient with this rare presentation of cryptococcoma mimicking a brain tumor are described. Case Report: A 54-year-old female patient presented to the emergency department with a rapid-onset progressive history of confusion and completely dependency for basic activities. Neuroimaging showed a left occipital lesion and neurosurgical treatment was proposed. From histopathological evaluation, a diagnosis of cryptococcoma was established. She received clinical support with antifungals, but despite optimal clinical treatment, her condition evolved to death. CONCLUSIONS: Cryptococcal infections have several forms of presentation and, in immunocompetent patients, their manifestation may be even more different. Cryptococcoma is an extremely rare presentation in which proper surgical and clinical treatment should be instituted as quickly as possible, but even so, there is a high mortality rate.

Abstract Purpose: To evaluate the efficacy of the cellulosic exopolysaccharide membrane (CEM) as a urethral reinforcement for urethrovesical anastomosis. Methods: Twenty eight rabbits were submitted to urethrovesical anastomosis with or without CEM reinforcement. The animals were divided into 4 groups: C7, CEM7, C14 and CEM14: (C= only anastomosis or CEM = anastomosis + CEM), evaluated after 7 weeks, and 14 weeks. The biointegration and biocompatibility of CEM were evaluated according to stenosis, fistula, urethral wall thickness, urethral epithelium, rate of inflammation and vascularization. Results: Between the two experimental groups, the difference in the number of stenosis or urinary fistula was not statistically significant. The morphometric analysis revealed preservation of urethral lumen, well adhered CEM without extrusion, a controlled inflammatory process and implant vascularization. The urothelium height remained constant over time after CEM reinforcement and the membrane wall was thicker, statistically, after 14 weeks. Conclusion: The absence of extrusion, stenosis or urinary fistula after 14 weeks of urethrovesical anastomosis demonstrates cellulosic exopolysaccharide membrane biocompatibility and biointegration with tendency to a thicker wall.

ABSTRACT This work aimed to evaluate the performance and egg quality of lightweight laying hens supplemented with a high biological value mineral, carbo-amino-phospho-chelates (CAPC), compared with inorganic minerals (sulfates), at different recommended values. A total of 320 Dekalb White hens, between 53 and 77 weeks of age, were distributed in a completely randomized design into two treatments, 10 replicates of 16 birds each. The treatments consisted of a reference diet formulated according to breed manual recommendations, in which one group was supplemented with a trace mineral source, CAPC (Cu, 8.6; Fe, 43.7; Mn, 56.4; Se, 0.34; and Zn, 43.7 mg/kg) and the other with a sulfate source, using the levels recommended in the breed manual (Cu, 8; Fe, 60; Mn, 70; Se, 0.25; and Zn, 60 mg/kg). There was no effect of trace mineral supplementation on egg production variables, feed conversion ratio by mass or by dozen eggs, and eggs per housed bird. However, there was an increase in feed intake and weight and mass of eggs when birds fed diet supplemented with CAPC. Regarding egg quality, CAPC supplementation increased the albumen weight and percentage, shell weight, thickness, and strength, and Haugh unit. The eggs from birds fed CAPC supplementation showed higher levels of iron and zinc when compared with eggs from birds fed the sulfate source diet. Better quality rates were observed in variables related to shelf life for the group that received CAPC. Trace mineral sources and recommendations in the diets of high genetic potential laying hens need to be reassessed and allow us to conclude that totally replacing the sulfate for different recommendations of CAPC in laying hen diets helps to improve quality characteristics as well as the nutritional value of eggs.

Fundamento:A deficiência de testosterona na insuficiência cardíaca (IC) está associada à diminuição da capacidade de exercício e mortalidade, mas o seu impacto sobre as readmissões é incerto. Além disso, sua relação com a ativação simpática é desconhecida.Objetivo:O presente estudo investigou o papel dos níveis de testosterona nas reinternações hospitalares, na mortalidade e na atividade nervosa simpática em pacientes com IC.Métodos:A testosterona total (TT) e a testosterona livre (TL) foram medidas em 110 pacientes do sexo masculino hospitalizados, com fração de ejeção < 45% eclassificação funcional da New York Heart Association (NYHA) IV, qualificados em dois grupos: 66 com baixos níveis de testosterona (BT) e 44 com testosterona normal (TN). Hipogonadismo foi definido como TT < 300 ng/dL e TL < 131 pmol/L. A atividade nervosa simpática muscular (ANSM) foi gravada por microneurografia em uma subpopulação de 27 pacientes.Resultados:O tempo de permanência hospitalar foi maior em pacientes BT em comparação com pacientes TN (37 ± 4 vs. 25 ± 4 dias; p = 0,008). Da mesma forma, o risco cumulativo de readmissão no período de um ano foi maior em pacientes BT (44% vs. 22%, p = 0,001). Na análise de uma única variável preditora, a testosterona total (HR = 2,77, IC 95% 1,58-4,85, p = 0,02) previu readmissão hospitalar no prazo de 90 dias. Na análise de uma única variável preditora, testosterona total (HR = 4,65, IC 95% 2,67-8,10, p = 0,009) e readmissão dentro de 90 dias (HR = 3,27, IC 95% 1,23-8,69, p = 0,02) previram aumento de mortalidade. Ativação neuro-humoral, estimada pela ANSM, foi significativamente maior nos pacientes BT em comparação aos do grupo TN (65 ± 3 vs. 51 ± 4 disparos/100BC; p < 0,001).Conclusão:Estes resultados sustentam o conceito de que BT é um fator de risco independente para a readmissão hospitalar dentro de 90 dias e para aumento de mortalidade em pacientes com IC. Além disso, observou-se aumento da ANSM em pacientes com baixos níveis de testosterona.

Background:Testosterone deficiency in patients with heart failure (HF) is associated with decreased exercise capacity and mortality; however, its impact on hospital readmission rate is uncertain. Furthermore, the relationship between testosterone deficiency and sympathetic activation is unknown.Objective:We investigated the role of testosterone level on hospital readmission and mortality rates as well as sympathetic nerve activity in patients with HF.Methods:Total testosterone (TT) and free testosterone (FT) were measured in 110 hospitalized male patients with a left ventricular ejection fraction < 45% and New York Heart Association classification IV. The patients were placed into low testosterone (LT; n = 66) and normal testosterone (NT; n = 44) groups. Hypogonadism was defined as TT < 300 ng/dL and FT < 131 pmol/L. Muscle sympathetic nerve activity (MSNA) was recorded by microneurography in a subpopulation of 27 patients.Results:Length of hospital stay was longer in the LT group compared to in the NT group (37 ± 4 vs. 25 ± 4 days; p = 0.008). Similarly, the cumulative hazard of readmission within 1 year was greater in the LT group compared to in the NT group (44% vs. 22%, p = 0.001). In the single-predictor analysis, TT (hazard ratio [HR], 2.77; 95% confidence interval [CI], 1.58–4.85; p = 0.02) predicted hospital readmission within 90 days. In addition, TT (HR, 4.65; 95% CI, 2.67–8.10; p = 0.009) and readmission within 90 days (HR, 3.27; 95% CI, 1.23–8.69; p = 0.02) predicted increased mortality. Neurohumoral activation, as estimated by MSNA, was significantly higher in the LT group compared to in the NT group (65 ± 3 vs. 51 ± 4 bursts/100 heart beats; p < 0.001).Conclusion:These results support the concept that LT is an independent risk factor for hospital readmission within 90 days and increased mortality in patients with HF. Furthermore, increased MSNA was observed in patients with LT.

The objective of this study was to determine the chlorine nutritional requirement of Japanese Quails during the laying phase, based on performance and egg quality parameters. A total of 240 Japanese quails were distributed according to a randomized block design, with five treatments and six replicates, with 8 birds each. The experiment lasted 84 days, divided in four cycles of 21 days each. Treatments consisted of a basal diet formulated to meet the nutritional requirements, except for chlorine, and four supplementation levels with ammonium chloride, generating the levels 0.8; 1.6; 2.4; 3.2 and 4.0 g/kg. The parameters evaluated were: feed intake (g/bird/day), egg production (egg/bird/day), egg weight (g), egg mass (g), egg mass conversion (g/g), conversion per dozen eggs (kg/dz), weight of yolk (g/100 g of egg), albumen (g/100g of egg) and shell (g/100 g of egg), specific gravity (g/cm³) and shell thickness (mm). As a result of this study, feed intake, egg weight, weights of albumen, yolk, shell and specific gravity were not affected by treatments. There was a quadratic behavior for egg production, egg mass, egg mass conversion, conversion per dozen eggs and shell thickness according to the chlorine levels in the diets, with the requirements for those parameters established at 1.54; 1.37; 1.39 and 2.78 g/kg, respectively. The recommendation is 1.39 g/kg of chlorine and 244.22 mEq/kg of electrolyte balance in diets for Japanese quails.

The objective of this study was to evaluate the requirement of digestible tryptophan for white laying hens in the production stage fed diets of different digestible tryptophan:digestible lysine ratios, as well as animal performance and histological alterations in their reproductive and digestive systems. A total of 280 white laying hens at 29 weeks of age were distributed in a completely randomized design with five treatments and seven replications with eight birds in each. The treatments consisted of a base feed, formulated with corn, soybean meal and corn gluten meal, and supplemented with the synthetic amino acids L-lysine, DL-methionine, L-threonine, L-isoleucine, L-arginine, and L-valine, so as to meet the nutritional requirements for laying hens, except for digestible tryptophan. The basal diet was supplemented with 0.00; 0.017; 0.035; 0.052; and 0.069 g/kg of L-tryptophan in substitution for corn starch with the objective of reaching the levels of 0.151; 0.167; 0.183; 0.199; and 0.215 g/kg of digestible tryptophan in the feed. For the ratio between digestible amino acids and lysine, the recommendation of Brazilian Tables for Poultry and Swine was followed, except for the digestible tryptophan:digestible lysine ratios, which were 19, 21, 23, 25 and 27 for each treatment. The variation in the digestible tryptophan:digestible lysine ratio promoted changes in performance and in the histological characteristics, improving the results. The digestible tryptophan:digestible lysine ratio of 24.5% in the feed of white laying hens in production stage promotes better animal performance and histological results.

The objective of this study was to estimate the requirements for maintenance and gain of crude protein in Japanese and European quails aged 16-36 days. To determine the maintenance requirements, one experiment was conducted in a completely randomized design with four decreasing feeding levels (100, 75, 50 and 25%) and four replicates per treatment. The method of comparative slaughter was used, through a feeding assay. A total of 352 quails from each strain were housed by supply level in 16 pens measuring 1.0 × 1.5 m, totaling 22 birds per cage under ambient temperature conditions (26±0.5 ºC). To estimate the requirement gains, one experiment was conducted with five groups of quails fed ad libitum and housed under controlled temperature of 18 ºC. All poultry were slaughtered at 16, 21, 26, 31 and 36 days of testing for determination of body composition in protein throughout growth. The requirement for maintenance of the Japanese quail differs from that obtained with the European quail. The protein was retained at the proportion of 32% for European quails and 25% for the Japanese quails. This difference in retention promoted estimate of 0.65 g/g gain in European quails and 0.84 g/g gain in Japanese quails. Quails should be fed diets formulated considering the requirement for protein of each genotype.

As exigências nutricionais de codornas diferem das de frangos e de galinhas poedeiras. Igualmente, as exigências de codornas japonesas também são distintas das de codornas europeias. Codornas exigem mais proteína (aminoácidos), menos cálcio na ração e digerem melhor os aminoácidos dos alimentos em comparação e a energia de alimentos fibrosos. Esses animais ainda aproveitam a energia do milho e do farelo de soja na mesma proporção que os frangos. Da mesma forma que os frangos, as codornas exigem mais energia para mantença, quando alojadas no piso, e menos, quando submetidas às altas temperaturas ambiente. Conclui-se que rações formuladas para frangos e galinhas não devem ser usadas na alimentação de codornas europeias e japonesas.

The nutritional requirements differ between quail chickens and laying hens and between Japanese quail and European quails. Quail require more protein (amino acids), less calcium and digest better amino acids of food in comparison with chickens, however, quails digest better energy of food fibrous, but in the same proportion as the chickens from corn and soybean meal. Likewise the chickens, the quail require more energy when on the floor and less when subjected to high ambient temperatures. It is concluded that diets for broiler chickens and should not be used as feed for European quails and Japanese.

The objective was to evaluate the effect of electrolyte balance in diets with reduced protein for semi-weighted Bovans Goldline laying hens in the second production cycle. The design was completely randomized with five treatments and seven replicates of six birds per experimental unit. Treatment 1 consisted of a control diet containing 165.0 g/kg crude protein (CP), formulated with the addition of DL-methionine to meet birds requirements during the experimental period. To compose the treatments 2-5 (BE149, BE167, BE185 and BE203), a basal diet with reduced protein (135.0 g/kg CP) supplemented with synthetic amino acids DL-methionine, L-lysine, L- threonine, L-valine and L-tryptophan was formulated. This basal diet was supplemented with potassium carbonate, to replace the inert, so as to provide four levels of potassium (5.86, 6.56, 7.26 and 7.96 g/kg) corresponding to the electrolyte balance of 171, 149, 167, 185 and 203 meq/kg, respectively. There was increased linear effect for feed intake and decreasing linear effect for albumen weight and yolk percentage and quadratic effect for conversion per dozen and per egg mass. Crude protein is recommended at 135.0g/kg with 6.77 g/kg potassium and electrolyte balance of 172.51meq/kg in the diet of semi-weighted laying hens in the second production cycle.

O presente artigo discute a espetacularização e a utilização da violência pela mídia para captar audiência, citando casos brasileiros, assim como os possíveis papéis da mídia no incentivo ou redução da violência. O tema violência perpassa a configuração das sociedades e seus diversos elementos, dentre os quais a mídia se destaca. O debate considera que os meios de comunicação, como produtores de sentido, podem contribuir para a transformação de comportamentos e hábitos sociais a partir de uma abordagem que valorize a igualdade, a cidadania, a liberdade e a segurança dos sujeitos. Ao restringir a importância e a ênfase ao assunto violência, o discurso midiático pode contribuir para uma cultura mais equânime no sentido de promover a redução dos índices de violência.

The present paper discusses the sensationalization of violence by the media as a means to increase audience ratings, citing Brazilian cases, as well as the possible roles of the media in promoting or curtailing violence. The theme of violence permeates the patterning of and the various dimensions of society, with emphasis on the media. The debate surrounding this issue assumes that the means of communication, as producers of meaning, can contribute to transform behaviors and social habits based on an approach that values equality, citizenship, freedom, and the safety of individuals. By restricting the importance and emphasis on violence as a topic, the discourse of the media may contribute towards making cultures more egalitarian in their efforts to reduce violence rates.