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ABSTRACT Introduction: Hemoglobinopathy Sβ-thalassemia (HbSβ-thal) has a wide range of clinical and laboratory severity. There is limited information on the natural history of HbSβ-thal and its modulating factors. We described the molecular, hematological, and clinical characteristics of a cohort of children with HbSβ-thal and estimated its incidence in Minas Gerais, Brazil. Methods: Laboratory and clinical data were retrieved from medical records. Molecular analysis was performed by HBB gene sequencing, PCR-RFLP, gap-PCR, and MLPA. Results: Eighty-nine children were included in the study. Fourteen alleles of β-thal mutations were identified. The incidence of HbSβ-thal in the state was 1 per 22,250 newborns. The most common βS-haplotypes were CAR and Benin. The most frequent βthal-haplotypes were V, II, and I. Coexistence of 3.7 kb HBA1/HBA2 deletion was present in 21.3 % of children. β-thalassemia mutations were associated with several clinical and laboratory features. In general, the incidence of clinical events per 100 patient-years was similar for children with HbSβ0-thal, IVS-I-5 G>A, and IVS-I-110 G>A. Children with HbSβ+-intermediate phenotypes had a more severe laboratory and clinical profile when compared with those with HbSβ+-mild ones. βS-haplotypes and α-thalassemia did not meaningfully influence the phenotype of children with HbSβ-thal. Conclusion: The early identification of b-thalassemia alleles may help the clinical management of these children. © 2023 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier España, S.L.U. This is an open access article under the CC BY-NC-ND license Introduction Sβthalassemia Sβ thalassemia HbSβthal HbSβ thal (HbSβ-thal severity factors molecular hematological Gerais Brazil Methods records sequencing PCRRFLP, PCRRFLP PCR RFLP, RFLP PCR-RFLP gapPCR, gapPCR gap PCR, gap-PCR MLPA Results Eightynine Eighty nine study βthal β identified 22250 22 250 22,25 newborns βShaplotypes βS haplotypes Benin βthalhaplotypes V II I 37 3 7 3. HBA1HBA2 HBAHBA HBA1 HBA2 HBA HBA1/HBA 213 21 21. βthalassemia features general 10 patientyears patient years HbSβ0thal, HbSβ0thal HbSβ0 thal, HbSβ0-thal IVSI5 IVSI IVS 5 IVS-I- G&gtA, GgtA G&gt A, G gt A G>A IVSI110 110 IVS-I-11 G&gtA. A. HbSβ+intermediate HbSβintermediate HbSβ+ intermediate HbSβ+mild HbSβmild mild ones αthalassemia α HbSβthal. thal. Conclusion bthalassemia b 202 Hematologia Celular España SLU S L U S.L.U BYNCND BY NC ND 2225 2 25 22,2 HBA1HBA IVS-I gtA G&gtA Ggt IVSI11 11 IVS-I-1 20 222 22, IVSI1

https://doi.org/10.1016/j.htct.2023.11.002

Salt stress and potassium fertilization on the agronomic performance of peanut crop
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Abreu, Fernanda da S.

; Viana, Thales V. de A.

; Sousa, Geocleber G. de

; Baldé, Bubacar

; Lacerda, Claudivan F. de

; Goes, Geovana F.

; Gomes, Krishna R.

; Cambissa, Paulo B. C.

Revista Caatinga

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2024, Volume 37 elocation e11996

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Em regiões semiáridas, o uso de águas salobras na irrigação pode reduzir o rendimento das culturas. No entanto, a utilização da adubação mineral vem sendo testada para mitigar o estresse salino. Neste sentido, objetivou-se avaliar o efeito do estresse salino em diversos estágios fenológicos na produtividade do amendoim, sob adubação potássica. O experimento foi realizado no período de agosto a novembro de 2021, na área experimental da Universidade da Integração da Lusofonia Afro-Brasileira (UNILAB), Redenção, Ceará. O delineamento experimental foi o inteiramente casualizado (DIC), em um esquema fatorial 6 × 3, com 6 repetições. Foram utilizadas seis estratégias de irrigação com água salobra a partir das seguintes fases: vegetativa (S1); florescimento (S2); aparecimento dos ginóforos (S3); formação de vagens (S4); frutificação (S5) e sem estresse salino (S6) e três doses de potássio; 0, 50 e 100% da dose recomendada. O uso de água salobra na fase vegetativa evidenciou menor comprimento da vagem, massa das vagens, número de vagem, número de vagens comerciais e produtividade. A dose correspondente à 100% recomendada de potássio mitigou o estresse salino nas fases de formação de vagens e floração, proporcionando maior número de vagem comercial, não comercial e total e massa de vagem. O uso de água de menor salinidade durante todo o ciclo proporcionou maior massa de vagem, número de vagens comerciais e produtividade. semiáridas culturas entanto sentido objetivouse objetivou se amendoim potássica 2021 AfroBrasileira Afro Brasileira UNILAB, UNILAB , (UNILAB) Redenção Ceará DIC, DIC (DIC) 3 repetições S1 S (S1) S2 (S2) S3 (S3) S4 (S4) S5 (S5 S6 (S6 0 5 100 floração 202 (UNILAB (DIC (S1 (S2 (S3 (S4 (S 10 20 1 2

ABSTRACT In semi-arid regions, the use of brackish water for irrigation can reduce crop yields. However, the use of mineral fertilizer has been tested to mitigate salt stress. In this context, the objective was to evaluate the effect of salt stress at different phenological stages on the yield of peanut under potassium fertilization. The experiment was carried out from August to November 2021, in the experimental area of the Universidade da Integração da Lusofonia Afro-Brasileira (UNILAB), Redenção, Ceará, Brazil. The experimental design was completely randomized (CRD), in a 6 × 3 factorial scheme, with 6 replicates. Six strategies of irrigation with brackish water were applied from the following stages: vegetative (S1); flowering (S2); gynophore appearance (S3); pod formation (S4); fruiting (S5) and without salt stress (S6), and three doses of potassium: 0, 50 and 100% of the recommended dose. The use of brackish water in the vegetative stage led to lower pod length, pod mass, number of pods, number of marketable pods and yield. The dose corresponding to 100% of the recommended potassium dose mitigated salt stress in the pod formation and flowering stages, promoting a greater number of marketable pods, number of non-marketable pods, total number of pods and pod mass. The use of water with lower salinity throughout the cycle promoted greater pod mass, number of marketable pods and yield. semiarid semi arid regions yields However context fertilization 2021 AfroBrasileira Afro Brasileira UNILAB, UNILAB , (UNILAB) Redenção Ceará Brazil CRD, CRD (CRD) scheme replicates S1 S (S1) S2 (S2) S3 (S3) S4 (S4) S5 (S5 S6, S6 (S6) 0 5 100 length mass nonmarketable non 202 (UNILAB (CRD (S1 (S2 (S3 (S4 (S (S6 10 20 1 2

https://doi.org/10.1590/1983-21252024v3711996rc

Tecnografias líticas do Holoceno médio na região central da América do Sul: tesselas culturais para um mosaico paleo-histórico (primeira parte)
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Viana, Sibeli A.

; Ramos, Marcos Paulo de M.

; Carbonelli, Juan Pablo

; Costa, Kaira S. R.

Revista del Museo de Antropología

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apr 2023, Volume 16 N. 1 Pages 317 - 338

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract This work, subdivided into the first part and the second part, produced a technographic overview of the lithic material of middle Holocene sites, located in the central portion of South America, in the macro-region dominated by savannas in the lowlands of South America. This analysis was possible through reflection on available bibliographic information. The description of the modes of making lithic tools was based on the recognition of the three technical principles based on the techno-functional perspective: debitage, shaping and affordance; and on the considerations about relationship between the active and prehensive parts of the pieces (also called “techno-functional categories”). As a result, a synthesis of the technological peculiarities and variabilities was obtained in areas little known or documented with regard to the lithic materiality. In the first part of the article, this overview highlighted that there was, in the groupings of the sites of the Cratón Amazônico, a localized contribution to the relative technical cultures on the part of the principles of debitage and shaping, without being completely homogeneous. In reference to the management of raw materials, a local supply of lithic resources can be seen near these sites.

Resumen Este trabajo, subdividido em primera y segunda parte, presenta un panorama tecnográfico del material lítico proveniente de sitios del Holoceno medio, localizados en la región central de América del Sur, específicamente de la macro-región dominada por sabanas en las tierras bajas. Este análisis fue posible a través de una revisión y reflexión sobre la información bibliográfica disponible. En base a un enfoque tecno-funcional, la descripción de los modos de manufactura de útiles líticos se basó en el reconocimiento de tres principios técnicos desde el punto de vista tecno-funcional: débitage, façonnage y affordance, así como de la consideración de la relación entre las porciones activas y prehensivas de las piezas interpretadas como útiles (denominadas también “categorías tecno- funcionales”). Como resultado se obtuvo una síntesis de las particularidades y variabilidades tecnológicas en áreas poco conocidas o documentadas en lo que se refiere a la materialidad lítica. En la primera parte del artículo, esta síntesis puso en evidencia que en los agrupamientos de los sitios del Cratón Amazónico existió un conjunto de culturas tecnicas relativamente homogéneas concentradas alrededor de los principios de débitage y façonnage. En cuanto a la gestión de la materia prima, se observa en estos sitios un aprovisionamiento local de recursos líticos.

https://doi.org/10.31048/1852.4826.v16.n1.38770

Tecnografias líticas do Holoceno médio na região central da América do Sul: tesselas culturais para um mosaico paleo-histórico (segunda parte)
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Ramos, Marcos Paulo de M.

; Carbonelli, Juan Pablo

; Viana, Sibeli A.

; Costa, Kaira S. R.

Revista del Museo de Antropología

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apr 2023, Volume 16 N. 1 Pages 339 - 358

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract This article constitutes the second part of the lithic technographic analysis of Middle Holocene sites in a vast macro-region, the central portion of South America: it includes the groups of sites B, C and D. A common element in all the analyzed sets is the presence of the techno-functional category B tools. In reference to the production mode, it is observed that the principle of debitage predominates in the area of analysis. However, its application was diverse; there are assemblages in which there was a predetermination about the making of flakes, others in which the cores were reintroduced as blanks or presented edges and there are other places in which façonnage confection flakes were reintroduced as blanks for tools. Other production principles have also been recorded: the principles of affordance (both in the exclusive productional expression and in its productional and functional expression) and shaping are observed in sites in groups A, C and D. Recognizing the different production modes is the starting point for thinking about how groups with different technical traditions have occupied different spaces in the region.

Resumen Este artículo conforma la segunda parte del análisis de las tecnografías líticas de los sitios del Holoceno medio en una extensa macrorregión, el sector central de América del Sur: abarca los agrupamientos B, C y D de los sitios. Un elemento común en todos los conjuntos analizados en la presencia de herramientas de la categoría tecno-funcional B. En referencia a los modos de producción se observa que el principio de debitagem predomina en el área de análisis. No obstante su aplicación es diversa; hay conjuntos donde existió una predeterminación sobre la confección de lascas, otros donde los núcleos son reintroducidos como soportes o presentando filos y otros sitios en donde se reintrodujeron lascas de confección de façonage como herramientas de soporte. El resto de los principios de producción también fueron registrados: el de afordancia (tanto en la producción instrumental como en su expresión produccional) y el de façonage se observan en sitios de los agrupamientos A, C y D. El reconocimiento de los diferentes modos de producción, es el punto de inicio para pensar como grupos con tradiciones técnicas diferentes, ocuparon espacios diversos en la región.

https://doi.org/10.31048/1852.4826.v16.n1.38769

Emotional, hyperactivity and inattention problems in adolescents with immunocompromising chronic diseases during the COVID-19 pandemic Emotional COVID19 COVID 19 COVID-1 COVID1 1 COVID-
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Campos, Reinan T.

; Lindoso, Livia

; Sousa, Renan A. de

; Helito, Alberto C.

; Ihara, Bianca P.

; Strabelli, Claudia A.A.

; Paradelas, Levi M.V.

; Carneiro, Beatriz O.L.

; Cardoso, Maria Paula R.

; Souza, Jean Paulo V. de

; Freire, Marianna R. de M.

; Astley, Camilla

; Laurentino, Moisés F.

; Buscatti, Izabel M.

; Kozu, Katia

; Aikawa, Nadia E.

; Sallum, Adriana M.E.

; Ferreira, Juliana CO.

; Simon, Juliana R.

; Viana, Vivianne S.L.

; Queiroz, Ligia B.

; Gualano, Bruno

; Roschel, Hamilton

; Pereira, Rosa Maria R.

; Toma, Ricardo K.

; Watanabe, Andréia

; Grangeiro, Patricia M.

; Casella, Caio B.

; Farhat, Sylvia C.

; Polanczyk, Guilherme V.

; Campos, Lucia Maria A.

; Silva, Clovis A.

Clinics

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2023, Volume 78 elocation 100167

Abstract: En | Text: En | PDF: En

Abstract Objective: To assess factors associated with emotional changes and Hyperactivity/Inattention (HI) motivated by COVID-19 quarantine in adolescents with immunocompromising diseases. Methods: A cross-sectional study included 343 adolescents with immunocompromising diseases and 108 healthy adolescents. Online questionnaires were answered including socio-demographic data and self-rated healthcare routine during COVID-19 quarantine and validated surveys: Strengths and Difficulties Questionnaire (SDQ), Pittsburgh Sleep Quality Index (PSQI), Pediatric Quality of Life Inventory 4.0 (PedsQL4.0). Results: The frequencies of abnormal emotional SDQ scores from adolescents with chronic diseases were similar to those of healthy subjects (110/343 [32%] vs. 38/108 [35%], p = 0.548), as well as abnormal hyperactivity/inattention SDQ scores (79/343 [23%] vs. 29/108 [27%], p = 0.417). Logistic regression analysis of independent variables associated with abnormal emotional scores from adolescents with chronic diseases showed: female sex (Odds Ratio [OR = 3.76]; 95% Confidence Interval (95% CI) 2.00–7.05; p < 0.001), poor sleep quality (OR = 2.05; 95% CI 1.08–3.88; p = 0.028) and intrafamilial violence during pandemic (OR = 2.17; 95% CI 1.12–4.19; p = 0.021) as independently associated with abnormal emotional scores, whereas total PedsQL score was inversely associated with abnormal emotional scores (OR = 0.95; 95% CI 0.93–0.96; p < 0.0001). Logistic regression analysis associated with abnormal HI scores from patients evidenced that total PedsQL score (OR = 0.97; 95% CI 0.95–0.99; p = 0.010], changes in medical appointments during the pandemic (OR = 0.39; 95% CI 0.19–0.79; p = 0.021), and reliable COVID-19 information (OR = 0.35; 95% CI 0.16–0.77; p = 0.026) remained inversely associated with abnormal HI scores. Conclusion: The present study showed emotional and HI disturbances in adolescents with chronic immunosuppressive diseases during the COVID-19 pandemic. It reinforces the need to promptly implement a longitudinal program to protect the mental health of adolescents with and without chronic illnesses during future pandemics. Objective HyperactivityInattention Hyperactivity Inattention (HI COVID19 COVID 19 COVID-1 Methods crosssectional cross sectional 34 10 sociodemographic socio demographic selfrated self rated surveys SDQ, , (SDQ) PSQI, PSQI (PSQI) 40 4 0 4. PedsQL4.0. PedsQL40 PedsQL4.0 . PedsQL4 (PedsQL4.0) Results 110/343 110343 110 (110/34 32% 32 [32% vs 38108 38 38/10 35%, 35 35% [35%] 0.548, 0548 0.548 548 0.548) hyperactivityinattention hyperactivity inattention 79/343 79343 79 (79/34 23% 23 [23% 29108 29 29/10 27%, 27 27% [27%] 0.417. 0417 0.417 417 0.417) Odds OR 3.76 376 3 76 3.76] 95 (95 2.00–7.05 200705 2 00 7 05 0.001, 0001 0.001 001 0.001) 2.05 205 1.08–3.88 108388 1 08 88 0.028 0028 028 2.17 217 17 1.12–4.19 112419 12 0.021 0021 021 0.95 095 0.93–0.96 093096 93 96 0.0001. 00001 0.0001 0.0001) 0.97 097 97 0.95–0.99 095099 99 0.010, 0010 0.010 010 0.010] 0.39 039 39 0.19–0.79 019079 0.021, 0.35 035 0.16–0.77 016077 16 77 0.026 0026 026 Conclusion pandemics COVID1 COVID- (SDQ (PSQI PedsQL4. (PedsQL4.0 110/34 11034 11 (110/3 [32 3810 38/1 [35% 054 0.54 54 79/34 7934 (79/3 [23 2910 29/1 [27% 041 0.41 41 3.7 37 9 (9 2.00–7.0 20070 000 0.00 2.0 20 1.08–3.8 10838 8 0.02 002 02 2.1 21 1.12–4.1 11241 0.9 09 0.93–0.9 09309 0000 0.000 0.95–0.9 09509 0.01 01 0.3 03 0.19–0.7 01907 0.16–0.7 01607 (PedsQL4. 110/3 1103 (110/ [3 381 38/ [35 0.5 5 79/3 793 (79/ [2 291 29/ [27 04 0.4 3. ( 2.00–7. 2007 0.0 2. 1.08–3. 1083 1.12–4. 1124 0. 0.93–0. 0930 0.95–0. 0950 0.19–0. 0190 0.16–0. 0160 (PedsQL4 110/ (110 [ 79/ (79 2.00–7 200 1.08–3 1.12–4 112 0.93–0 093 0.95–0 0.19–0 019 0.16–0 016 (PedsQL (11 (7 2.00– 1.08– 1.12– 0.93– 0.95– 0.19– 0.16– (1 2.00 1.08 1.12 0.93 0.19 0.16 1.0 1.1 0.1 1.

https://doi.org/10.1016/j.clinsp.2023.100167

N-Methyl-(2S,4R)-trans-4-hydroxy-L-proline isolated Sideroxylon obtusifolium attenuates TPA-induced irritant contact dermatitis in mice NMethyl2S,4Rtrans4hydroxyLproline NMethyl2S4Rtrans4hydroxyLproline NMethylSRtranshydroxyLproline N Methyl 2S,4R trans 4 hydroxy L proline 2S 4R S R TPAinduced TPA induced NMethyl2S 4Rtrans4hydroxyLproline NMethyl Rtrans hydroxyLproline 2S4R SR NMethylS RtranshydroxyLproline
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NUNES, PAULO IURY G.

; VIANA, ANA FLÁVIA S.C.

; SASAHARA, GREYCE L.

; SANTOS, SABRINA M. DOS

; ALVES, ANA PAULA N.N.

; SILVEIRA, EDILBERTO R.

; SANTOS, FLÁVIA A.

Anais da Academia Brasileira de Ciências

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2023, Volume 95 N. 3 elocation e20220919

Abstract: En | Text: En | PDF: En

Abstract Dermatitis is defined as a set of inflammatory diseases that affect the skin, with varied causes. Among the different types of dermatitis, contact dermatitis is the most prevalent. Although the current therapy is often effective, it is associated with adverse effects and the possibility of drug tolerance. N-Methyl-(2S, 4R)-trans-4-hydroxy-L-proline is a L-proline amino acid derivative found in the leaves of Sideroxylon obtusifolium, a species traditionally used to treat inflammatory diseases. The aim of this study was to investigate the topical anti-inflammatory effect of N-methyl-(2S, 4R)-trans-4-hydroxy-L-proline (NMP) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced irritant contact dermatitis in mice. Topically administered NMP, at doses of 0.03 − 0.50 mg/ear, reduced TPA-induced ear edema and neutrophil migration, as evidenced by low tissue myeloperoxidase activity and verified by histological examination. In addition, NMP (0.06 mg/ear) reduced tissue levels of pro-inflammatory cytokines (TNF-α, IL-6, IL-1β, INF-γ and MCP-1) and of the anti-inflammatory cytokine IL-10, and reduced gene expression of TNF-α, IL-6 and IL-1β increased by TPA. The data suggest that N-methyl-(2S, 4R)-trans-4-hydroxy-L-proline acts as a topical anti-inflammatory agent that decreases the expression of inflammatory cytokines, making it useful for the treatment of skin inflammation. Further investigations are necessary for its development as a therapeutic agent. causes prevalent effective tolerance NMethyl2S, NMethyl2S NMethylS N Methyl 2S, 2S S N-Methyl-(2S 4Rtrans4hydroxyLproline RtranshydroxyLproline 4R trans 4 hydroxy L proline R Lproline obtusifolium antiinflammatory anti Nmethyl2S, Nmethyl2S NmethylS methyl N-methyl-(2S (NMP 12Otetradecanoylphorbol13acetate Otetradecanoylphorbolacetate 12 O tetradecanoylphorbol 13 acetate TPAinduced TPA induced mice 003 0 03 0.0 050 50 0.5 mgear mg mg/ear migration examination addition 0.06 006 06 (0.0 proinflammatory pro TNFα, TNFα TNF α, α (TNF-α IL6, IL6 IL 6, 6 IL1β, IL1β ILβ 1β, 1β β INFγ INF γ MCP1 MCP 1 MCP-1 IL10, IL10 10, 10 IL-10 TNF-α IL- inflammation NMethyl Rtrans hydroxyLproline Nmethyl Otetradecanoylphorbol 00 0. 05 5 (0. MCP- IL1 IL-1 (0 (

https://doi.org/10.1590/0001-3765202320220919

Enzymatic stoichiometry in tropical soil under pure and mixed plantations of eucalyptus with N2-fixing trees
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Pereira, Arthur Prudêncio de Araujo

; Araujo, Ademir Sérgio Ferreira

; Santana, Maiele Cintra

; Lima, Antonio Yan Viana

; Araujo, Victor Lucas Vieira Prudêncio de

; Verma, Jay Prakash

; Cardoso, Elke Jurandy Bran Nogueira

Scientia Agricola

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2023, Volume 80 elocation e20210283

Abstract: En | Text: En | PDF: En

ABSTRACT: Soil enzymes play a fundamental role in nutrient cycling in forest systems. The stoichiometry of C, N, and P–acquiring enzymes has been used to indicate nutrient limitation in the soil. However, the enzymatic stoichiometry remains poorly understood in pure and mixed eucalypt plantations. Thus, this study aims to assess the activity of enzymes in the soil to address the hypothesis that the introduction of N2-fixing trees could influence the enzymatic stoichiometry on C, N, and P cycling. The activity of β-glucosidase (BG), urease (U), and acid phosphatase (AP) was assessed in soil (0-20 cm depth) of pure Eucalyptus grandis without (E) and with N fertilization (E+N), and a mixed system with E. grandis and Acacia mangium (E+A), and a pure A. mangium (A) plantation at 27 and 39 months after planting. The activities of BG/U, BG/AP, and U/AP were used to calculate the enzyme C/N, C/P, and N/P ratios, respectively. Rates of N–acquiring enzymes were higher in E and E+N, while soil microorganisms invested in P–acquiring enzymes in A and E+A. The vector length and angle demonstrated that C demand by microorganisms does not change in relation to N and P, regardless of the treatment. However, N demand decreased in relation to P in A and E+A (mainly at 27 months). Our results suggest that enzymes activity in pure eucalypt systems is limited for their soil-litter nutrient contents. At the same time while acacia and mixed plantation seem to invest in P–acquiring enzymes to improve biological N2 fixation promoted by diazotrophic bacteria associated to acacia.

https://doi.org/10.1590/1678-992x-2021-0283

Gas exchange and growth of zucchini crop subjected to salt and water stress
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Sousa, Henderson C.

; Sousa, Geocleber G. de

; Cambissa, Paulo B. C.

; Lessa, Carla I. N.

; Goes, Geovana F.

; Silva, Fred D. B. da

; Abreu, Fernanda da S.

; Viana, Thales V. de A.

Revista Brasileira de Engenharia Agrícola e Ambiental

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nov 2022, Volume 26 N. 11 Pages 815 - 822

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A região semiárida apresenta o problema inerente de acúmulo de sais no solo devido ao uso de irrigação com água salobra, e o déficit hídrico que compromete o crescimento e os índices fisiológicos das culturas. Objetivou-se com este trabalho avaliar o efeito do estresse salino e hídrico no crescimento e nas trocas gasosas da cultura da abobrinha cv. Caserta. O trabalho foi realizado em área pertencente à Universidade da Integração Internacional da Lusofonia Afro-Brasileira, Redenção, Ceará, Brasil. O delineamento experimental utilizado foi inteiramente casualizado, em esquema fatorial 5 × 2 com cinco níveis de condutividade elétrica da água de irrigação - CEa (0,5, 1,0, 1,5, 2,0 e 2,5 dS m-1), e dois regimes hídricos (50 e 100% da evapotranspiração potencial da cultura - ETc) com cinco repetições. Aos 36 dias após a semeadura foram avaliadas as variaveis:taxa de assimilação de CO2, transpiração, condutância estomática, concentração interna de carbono, temperatura foliar, índice relativo de clorofila e a eﬁciência do uso da água. Aos 45 dias após a semeadura, foram avaliadas as seguintes variáveis: altura da planta, diâmetro do caule, número de folhas e área foliar. O uso de água salobra (1 a 2,5 dS m-1) reduz os parâmetros de crescimento da abobrinha cv. Caserta. O aumento da CEa ocasionou redução nas variáveis fisiológicas. A lâmina de 100% proporcionou maiores valores para as variáveis taxa de assimilação de CO2, transpiração, e eficiência instantânea no uso da água, e a lâmina de 50% para concentração interna de carbono, com o aumento da CEa.

ABSTRACT Semi-arid regions present the inherent problem of accumulation of salts in the soil due to the use of brackish water for irrigation, and water deficit compromises the growth and physiological indices of crops. This study evaluated the effect of salt and water stress on growth and gas exchange in the zucchini cv. Caserta crop. The study was conducted at the University of International Integration of Afro-Brazilian Lusophony, Redenção, Ceará State, Brazil. The experimental design was completely randomized, in a 5 × 2 factorial scheme with five levels of electrical conductivity of the irrigation water - ECw (0.5, 1.0, 1.5, 2.0, and 2.5 dS m-1) and two water regimes (50 and 100% of the potential crop evapotranspiration - ETc), with five replicates. At 36 days after sowing, the following traits were evaluated: CO2 assimilation rate, transpiration, stomatal conductance, internal carbon concentration, leaf temperature, relative chlorophyll index, and water use efficiency. At 45 days after sowing, the plant height, stem diameter, number of leaves, and leaf area were also evaluated. The use of brackish water (1 to 2.5 dS m-1) reduced the growth parameters of zucchini cv. Caserta. The increase in ECw caused a decline in the physiological traits. Under 100% ETc, higher values of CO2 assimilation rate, transpiration, and instantaneous water use efficiency were recorded, and there was 50% ETc for internal carbon concentration, even with the increase in ECw.

https://doi.org/10.1590/1807-1929/agriambi.v26n11p815-822

Natural vertical cotransmission of Dengue virus and Chikungunya virus from Aedes aegypti in Brumado, Bahia, Brazil
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Granger Neto, Henry Paul

; Rocha, Cínthya Viana Souza

; Correia, Thiago Macêdo Lopes

; Silva, Natalia Maria Pereira da

; Chaves, Bárbara Aparecida

; Secundino, Nágila Francinete Costa

; Pimenta, Paulo Filemon Paolucci

; Melo, Fabrício Freire de

Revista da Sociedade Brasileira de Medicina Tropical

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2022, Volume 55 elocation e0427-2021

Abstract: En | Text: En | PDF: En

ABSTRACT Background: Arthropod-borne viruses have recently emerged and are pathogens of various human diseases, including dengue, zika, and chikungunya viruses. Methods: We collectedAedes aegyptilarvae (N = 20) from Brumado, Bahia, Brazil, and treated and individually preserved the specimens. We analyzed the samples for dengue, zika, and chikungunya viruses using molecular biology methods. Results: We found that 25% (N = 5) and 15% (N = 3) were positive exclusively for dengue and chikungunya viruses, respectively; 15% (N = 3) were coinfected with both. Conclusions: This is the first report of dengue and chikungunya virus coinfection in A. aegypti larvae.

https://doi.org/10.1590/0037-8682-0427-2021

10.

Longitudinal measurement invariance of neuropsychological tests in a diverse sample from the ELSA-Brasil study
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Bertola, Laiss

; Benseñor, Isabela M.

; Gross, Alden L.

; Caramelli, Paulo

; Barreto, Sandhi Maria

; Moreno, Arlinda B.

; Griep, Rosane H.

; Viana, Maria Carmen

; Lotufo, Paulo A.

; Suemoto, Claudia K.

Brazilian Journal of Psychiatry

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jun 2021, Volume 43 N. 3 Pages 254 - 261

Abstract: En | Text: En | PDF: En

Objective: Longitudinal measurement invariance analyses are an important way to assess a test’s ability to estimate the underlying construct over time, ensuring that cognitive scores across visits represent a similar underlying construct, and that changes in test performance are attributable to individual change in cognitive abilities. We aimed to evaluate longitudinal measurement invariance in a large, social and culturally diverse sample over time. Methods: A total of 5,949 participants from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) were included, whose cognition was reassessed after four years. Longitudinal measurement invariance analysis was performed by comparing a nested series of multiple-group confirmatory factor analysis models (for memory and executive function factors). Results: Configural, metric, scalar and strict invariance were tested and supported over time. Conclusion: Cognitive temporal changes in this sample are more likely to be due to normal and/or pathological aging. Testing longitudinal measurement invariance is essential for diverse samples at high risk of dementia, such as in low- and middle-income countries.

https://doi.org/10.1590/1516-4446-2020-0978 184 downloads

11.

Práticas de ressuscitação volêmica em unidades de terapia intensiva brasileiras: uma análise secundária do estudo Fluid-TRIPS
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Freitas, Flavio Geraldo Rezende de

; Hammond, Naomi

; Li, Yang

; Azevedo, Luciano Cesar Pontes de

; Cavalcanti, Alexandre Biasi

; Taniguchi, Leandro

; Gobatto, André

; Japiassú, André Miguel

; Bafi, Antonio Tonete

; Mazza, Bruno Franco

; Noritomi, Danilo Teixeira

; Dal-Pizzol, Felipe

; Bozza, Fernando

; Salluh, Jorge Ibrahin Figueira

; Westphal, Glauco Adrieno

; Soares, Márcio

; Assunção, Murillo Santucci César de

; Lisboa, Thiago

; Lobo, Suzana Margarete Ajeje

; Barbosa, Achilles Rohlfs

; Ventura, Adriana Fonseca

; Souza, Ailson Faria de

; Silva, Alexandre Francisco

; Toledo, Alexandre

; Reis, Aline

; Cembranel, Allan

; Rea Neto, Alvaro

; Gut, Ana Lúcia

; Justo, Ana Patricia Pierre

; Santos, Ana Paula

; Albuquerque, André Campos D. de

; Scazufka, André

; Rodrigues, Antonio Babo

; Fernandino, Bruno Bonaccorsi

; Silva, Bruno Goncalves

; Vidal, Bruno Sarno

; Pinheiro, Bruno Valle

; Pinto, Bruno Vilela Costa

; Feijo, Carlos Augusto Ramos

; Abreu Filho, Carlos de

; Bosso, Carlos Eduardo da Costa Nunes

; Moreira, Carlos Eduardo Nassif

; Ramos, Carlos Henrique Ferreira

; Tavares, Carmen

; Arantes, Cidamaiá

; Grion, Cintia

; Mendes, Ciro Leite

; Kmohan, Claudio

; Piras, Claudio

; Castro, Cristine Pilati Pileggi

; Lins, Cyntia

; Beraldo, Daniel

; Fontes, Daniel

; Boni, Daniela

; Castiglioni, Débora

; Paisani, Denise de Moraes

; Pedroso, Durval Ferreira Fonseca

; Mattos, Ederson Roberto

; Brito Sobrinho, Edgar de

; Troncoso, Edgar M. V.

; Rodrigues Filho, Edison Moraes

; Nogueira, Eduardo Enrico Ferrari

; Ferreira, Eduardo Leme

; Pacheco, Eduardo Souza

; Jodar, Euzebio

; Ferreira, Evandro L. A.

; Araujo, Fabiana Fernandes de

; Trevisol, Fabiana Schuelter

; Amorim, Fábio Ferreira

; Giannini, Fabio Poianas

; Santos, Fabrício Primitivo Matos

; Buarque, Fátima

; Lima, Felipe Gallego

; Costa, Fernando Antonio Alvares da

; Sad, Fernando Cesar dos Anjos

; Aranha, Fernando G.

; Ganem, Fernando

; Callil, Flavio

; Costa Filho, Francisco Flávio

; Dall´Arto, Frederico Toledo Campo

; Moreno, Geovani

; Friedman, Gilberto

; Moralez, Giulliana Martines

; Silva, Guilherme Abdalla da

; Costa, Guilherme

; Cavalcanti, Guilherme Silva

; Betônico, Gustavo Navarro

; Reis, Hélder

; Araujo, Helia Beatriz N.

; Hortiz Júnior, Helio Anjos

; Guimaraes, Helio Penna

; Urbano, Hugo

; Maia, Israel

; Santiago Filho, Ivan Lopes

; Farhat Júnior, Jamil

; Alvarez, Janu Rangel

; Passos, Joel Tavares

; Paranhos, Jorge Eduardo da Rocha

; Marques, José Aurelio

; Moreira Filho, José Gonçalves

; Andrade, Jose Neto

; Sobrinho, José Onofre de C

; Bezerra, Jose Terceiro de Paiva

; Alves, Juliana Apolônio

; Ferreira, Juliana

; Gomes, Jussara

; Sato, Karina Midori

; Gerent, Karine

; Teixeira, Kathia Margarida Costa

; Conde, Katia Aparecida Pessoa

; Martins, Laércia Ferreira

; Figueirêdo, Lanese

; Rezegue, Leila

; Tcherniacovsk, Leonardo

; Ferraz, Leone Oliveira

; Cavalcante, Liane

; Rabelo, Ligia

; Miilher, Lilian

; Garcia, Lisiane

; Tannous, Luana

; Hajjar, Ludhmila Abrahão

; Paciência, Luís Eduardo Miranda

; Cruz Neto, Luiz Monteiro da

; Bley, Macia Valeria

; Sousa, Marcelo Ferreira

; Puga, Marcelo Lourencini

; Romano, Marcelo Luz Pereira

; Nobrega, Marciano

; Arbex, Marcio

; Rodrigues, Márcio Leite

; Guerreiro, Márcio Osório

; Rocha, Marcone

; Alves, Maria Angela Pangoni

; Rosa, Maria Doroti

; Dias, Mariza D’Agostino

; Martins, Miquéias

; Oliveira, Mirella de

; Moretti, Miriane Melo Silveira

; Matsui, Mirna

; Messender, Octavio

; Santarém, Orlando Luís de Andrade

; Silveira, Patricio Júnior Henrique da

; Vassallo, Paula Frizera

; Antoniazzi, Paulo

; Gottardo, Paulo César

; Correia, Paulo

; Ferreira, Paulo

; Torres, Paulo

; Silva, Pedro Gabrile M. de Barros e

; Foernges, Rafael

; Gomes, Rafael

; Moraes, Rafael

; Nonato filho, Raimundo

; Borba, Renato Luis

; Gomes, Renato V

; Cordioli, Ricardo

; Lima, Ricardo

; López, Ricardo Pérez

; Gargioni, Ricardo Rath de Oliveira

; Rosenblat, Richard

; Souza, Roberta Machado de

; Almeida, Roberto

; Narciso, Roberto Camargo

; Marco, Roberto

; waltrick, Roberto

; Biondi, Rodrigo

; Figueiredo, Rodrigo

; Dutra, Rodrigo Santana

; Batista, Roseane

; Felipe, Rouge

; Franco, Rubens Sergio da Silva

; Houly, Sandra

; Faria, Sara Socorro

; Pinto, Sergio Felix

; Luzzi, Sergio

; Sant’ana, Sergio

; Fernandes, Sergio Sonego

; Yamada, Sérgio

; Zajac, Sérgio

; Vaz, Sidiner Mesquita

; Bezerra, Silvia Aparecida Bezerra

; Farhat, Tatiana Bueno Tardivo

; Santos, Thiago Martins

; Smith, Tiago

; Silva, Ulysses V. A.

; Damasceno, Valnei Bento

; Nobre, Vandack

; Dantas, Vicente Cés de Souza

; Irineu, Vivian Menezes

; Bogado, Viviane

; Nedel, Wagner

; Campos Filho, Walther

; Dantas, Weidson

; Viana, William

; Oliveira Filho, Wilson de

; Delgadinho, Wilson Martins

; Finfer, Simon

; Machado, Flavia Ribeiro

Revista Brasileira de Terapia Intensiva

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apr 2021, Volume 33 N. 2 Pages 206 - 218

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Descrever as práticas de ressuscitação volêmica em unidades de terapia intensiva brasileiras e compará-las com as de outros países participantes do estudo Fluid-TRIPS. Métodos: Este foi um estudo observacional transversal, prospectivo e internacional, de uma amostra de conveniência de unidades de terapia intensiva de 27 países (inclusive o Brasil), com utilização da base de dados Fluid-TRIPS compilada em 2014. Descrevemos os padrões de ressuscitação volêmica utilizados no Brasil em comparação com os de outros países e identificamos os fatores associados com a escolha dos fluidos. Resultados: No dia do estudo, foram incluídos 3.214 pacientes do Brasil e 3.493 pacientes de outros países, dos quais, respectivamente, 16,1% e 26,8% (p < 0,001) receberam fluidos. A principal indicação para ressuscitação volêmica foi comprometimento da perfusão e/ou baixo débito cardíaco (Brasil 71,7% versus outros países 56,4%; p < 0,001). No Brasil, a percentagem de pacientes que receberam soluções cristaloides foi mais elevada (97,7% versus 76,8%; p < 0,001), e solução de cloreto de sódio a 0,9% foi o cristaloide mais comumente utilizado (62,5% versus 27,1%; p < 0,001). A análise multivariada sugeriu que os níveis de albumina se associaram com o uso tanto de cristaloides quanto de coloides, enquanto o tipo de prescritor dos fluidos se associou apenas com o uso de cristaloides. Conclusão: Nossos resultados sugerem que cristaloides são usados mais frequentemente do que coloides para ressuscitação no Brasil, e essa discrepância, em termos de frequências, é mais elevada do que em outros países. A solução de cloreto de sódio 0,9% foi o cristaloide mais frequentemente prescrito. Os níveis de albumina sérica e o tipo de prescritor de fluidos foram os fatores associados com a escolha de cristaloides ou coloides para a prescrição de fluidos.

Abstract Objective: To describe fluid resuscitation practices in Brazilian intensive care units and to compare them with those of other countries participating in the Fluid-TRIPS. Methods: This was a prospective, international, cross-sectional, observational study in a convenience sample of intensive care units in 27 countries (including Brazil) using the Fluid-TRIPS database compiled in 2014. We described the patterns of fluid resuscitation use in Brazil compared with those in other countries and identified the factors associated with fluid choice. Results: On the study day, 3,214 patients in Brazil and 3,493 patients in other countries were included, of whom 16.1% and 26.8% (p < 0.001) received fluids, respectively. The main indication for fluid resuscitation was impaired perfusion and/or low cardiac output (Brazil: 71.7% versus other countries: 56.4%, p < 0.001). In Brazil, the percentage of patients receiving crystalloid solutions was higher (97.7% versus 76.8%, p < 0.001), and 0.9% sodium chloride was the most commonly used crystalloid (62.5% versus 27.1%, p < 0.001). The multivariable analysis suggested that the albumin levels were associated with the use of both crystalloids and colloids, whereas the type of fluid prescriber was associated with crystalloid use only. Conclusion: Our results suggest that crystalloids are more frequently used than colloids for fluid resuscitation in Brazil, and this discrepancy in frequencies is higher than that in other countries. Sodium chloride (0.9%) was the crystalloid most commonly prescribed. Serum albumin levels and the type of fluid prescriber were the factors associated with the choice of crystalloids or colloids for fluid resuscitation.

https://doi.org/10.5935/0103-507x.20210028 273 downloads

12.

LEAF ANATOMY CHARACTERIZATION OF FOUR Apochloa SPECIES: A C3 GENUS RELATED TO EVOLUTION OF C4 PATHWAY IN GRASSES
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MENDONÇA, Ane Marcela das Chagas

; VIANA, Pedro Lage

; BARBOSA, João Paulo Rodrigues Alves Delfino

Acta Biológica Colombiana

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apr 2021, Volume 26 N. 1 Pages 12 - 18

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

RESUMEN Las características de la anatomía de la hoja proporcionan evidencias importantes sobre la transición entre las vías C3 y C4. La fotosíntesis C4 surgió para reducir la tasa de fotorrespiración C3, concentrando el CO2 alrededor del sitio de la Rubisco y utilizando estructuras y maquinaria ya presentes en las plantas C3. En monocotiledóneas, se observa un alto número de linajes C4, la mayoría de ellas filogenéticamente relacionadas con grupos C3. El género C3 Apochloa, que pertenece a la subtribu Arthropogoninae, está relacionado con dos géneros C4 Coleataenia and Cyphonanthus. En este contexto, el objetivo fue evaluar cuatro especies de Apochloa para establecer las características anatómicas relacionadas con la evolución de la via C4 en este grupo. Se colectaron hojas completamente expandidas de A. euprepes, A. lorea, A. molinioides y A. poliophylla y se determinaron las características de las células del mesófilo (M) y del haz de la vaina (HV) a partir de secciones transversales de la hoja. Las especies presentaron una anatomía rústica de Kranz con células HV agrandadas y de distribución radial, con pocas organelas organizadas en posición centrífuga. Aunque las modificaciones de las células HV están probablemente relacionadas con el mantenimiento del estado hídrico de la planta, se puede inferir que facilitan el establecimiento de la fotosíntesis en los géneros C4 relacionados.

ABSTRACT Leaf anatomy characteristics provide important evidences about the transition between C3 and C4 pathways. The C4 photosynthesis pathway allowed to reduce the C3 photorespiratory rate, concentrating CO2 around the Rubisco site and using structures and machinery already presented in C3 plants. In monocots, it is observed a high number of C4 lineages, most of them phylogenetically related to C3 groups. The genus Apochloa (C3), subtribe Arthropogoninae, is related to two C4 genera Coleataenia and Cyphonanthus. The aim of this study was to evaluate four Apochloa species in order to establish anatomical characteristics related to the evolution of C4 pathway in this group. By means of transverse sections fully expanded leaves of A. euprepes, A. lorea, A. molinioides, and A. poliophylla were collected and the characteristics of the mesophyll (M) and bundle sheath (BS) cells were determined. These species showed a rustic Kranz anatomy with enlarged and radial arranged BS cells, which have few organelles organized in a centrifugal position. Although the modifications of BS cells are probably related to the maintenance of plant water status, we also discuss the evolution for the establishment of C4 photosynthesis in the related C4 genera.

https://doi.org/10.15446/abc.v26n1.83228 425 downloads

13.

Diretrizes Brasileiras de Hipertensão Arterial – 2020
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Barroso, Weimar Kunz Sebba

; Rodrigues, Cibele Isaac Saad

; Bortolotto, Luiz Aparecido

; Mota-Gomes, Marco Antônio

; Brandão, Andréa Araujo

; Feitosa, Audes Diógenes de Magalhães

; Machado, Carlos Alberto

; Poli-de-Figueiredo, Carlos Eduardo

; Amodeo, Celso

; Mion Júnior, Décio

; Barbosa, Eduardo Costa Duarte

; Nobre, Fernando

; Guimarães, Isabel Cristina Britto

; Vilela-Martin, José Fernando

; Yugar-Toledo, Juan Carlos

; Magalhães, Maria Eliane Campos

; Neves, Mário Fritsch Toros

; Jardim, Paulo César Brandão Veiga

; Miranda, Roberto Dischinger

; Póvoa, Rui Manuel dos Santos

; Fuchs, Sandra C

; Alessi, Alexandre

; Lucena, Alexandre Jorge Gomes de

; Avezum, Alvaro

; Sousa, Ana Luiza Lima

; Pio-Abreu, Andrea

; Sposito, Andrei Carvalho

; Pierin, Angela Maria Geraldo

; Paiva, Annelise Machado Gomes de

; Spinelli, Antonio Carlos de Souza

; Nogueira, Armando da Rocha

; Dinamarco, Nelson

; Eibel, Bruna

; Forjaz, Cláudia Lúcia de Moraes

; Zanini, Claudia Regina de Oliveira

; Souza, Cristiane Bueno de

; Souza, Dilma do Socorro Moraes de

; Nilson, Eduardo Augusto Fernandes

; Costa, Elisa Franco de Assis

; Freitas, Elizabete Viana de

; Duarte, Elizabeth da Rosa

; Muxfeldt, Elizabeth Silaid

; Lima Júnior, Emilton

; Campana, Erika Maria Gonçalves

; Cesarino, Evandro José

; Marques, Fabiana

; Argenta, Fábio

; Consolim-Colombo, Fernanda Marciano

; Baptista, Fernanda Spadotto

; Almeida, Fernando Antonio de

; Borelli, Flávio Antonio de Oliveira

; Fuchs, Flávio Danni

; Plavnik, Frida Liane

; Salles, Gil Fernando

; Feitosa, Gilson Soares

; Silva, Giovanio Vieira da

; Guerra, Grazia Maria

; Moreno Júnior, Heitor

; Finimundi, Helius Carlos

; Back, Isabela de Carlos

; Oliveira Filho, João Bosco de

; Gemelli, João Roberto

; Mill, José Geraldo

; Ribeiro, José Marcio

; Lotaif, Leda A. Daud

; Costa, Lilian Soares da

; Magalhães, Lucélia Batista Neves Cunha

; Drager, Luciano Ferreira

; Martin, Luis Cuadrado

; Scala, Luiz César Nazário

; Almeida, Madson Q.

; Gowdak, Marcia Maria Godoy

; Klein, Marcia Regina Simas Torres

; Malachias, Marcus Vinícius Bolívar

; Kuschnir, Maria Cristina Caetano

; Pinheiro, Maria Eliete

; Borba, Mario Henrique Elesbão de

; Moreira Filho, Osni

; Passarelli Júnior, Oswaldo

; Coelho, Otavio Rizzi

; Vitorino, Priscila Valverde de Oliveira

; Ribeiro Junior, Renault Mattos

; Esporcatte, Roberto

; Franco, Roberto

; Pedrosa, Rodrigo

; Mulinari, Rogerio Andrade

; Paula, Rogério Baumgratz de

; Okawa, Rogério Toshiro Passos

; Rosa, Ronaldo Fernandes

; Amaral, Sandra Lia do

; Ferreira-Filho, Sebastião R.

; Kaiser, Sergio Emanuel

; Jardim, Thiago de Souza Veiga

; Guimarães, Vanildo

; Koch, Vera H.

; Oigman, Wille

; Nadruz, Wilson

Arquivos Brasileiros de Cardiologia

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mar 2021, Volume 116 N. 3 Pages 516 - 658

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20201238 10948 downloads

14.

Poor Sleep quality and health-related quality of life impact in adolescents with and without chronic immunosuppressive conditions during COVID-19 quarantine
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Helito, Alberto C.

; Lindoso, Livia

; Sieczkowska, Sofia M.

; Astley, Camilla

; Queiroz, Ligia B.

; Rose, Natalia

; Santos, Claudia Renata P.

; Bolzan, Thalis

; Peralta, Rita María I.A.

; Franco, Ruth R.

; Cominato, Louise

; Pereira, Rosa Maria R.

; Tannuri, Uenis

; Campos, Lucia Maria A.

; Lourenço, Benito

; Toma, Ricardo K.

; Medeiros, Karina

; Watanabe, Andréia

; Grangeiro, Patricia Moreno

; Farhat, Sylvia C.

; Casella, Caio B.

; Polanczyk, Guilherme V.

; Gualano, Bruno

; Silva, Clovis A.

; Sallum, Adriana M. E.

; Iraha, Amanda Y.

; Ihara, Bianca P.

; Mazzolani, Bruna C.

; Martinez, Claudia A.

; Strabelli, Claudia A. A.

; Fonseca, Claudia B.

; Lima, Dandara C. C.

; Setoue, Debora N. D.

; Roz, Deborah F. P.

; Smaira, Fabiana I.

; Roschel, Hamilton

; Miyatani, Helena T.

; Marques, Isabela G.

; Oba, Jane

; Ferreira, Juliana C. O.

; Simon, Juliana R.

; Kozu, Katia

; Saccani, Ligia P.

; Martiniano, Lorena V. M.

; Miranda, Luana C. A.

; Silva, Luiz E. V.

; Laurentino, Moisés F.

; Aikawa, Nadia E.

; Sakita, Neusa K.

; Tanigava, Nicolas Y.

; Pereira, Paulo R. A.

; Palmeira, Patrícia

; Angelo, Simone S.

; Lavorato, Sofia S. M.

; Bernardes, Tamires M.

; Franco, Tathiane C.

; Viana, Vivianne S. L.

; Barros, Vera P. M. F. R.

; Zheng, Yingying

Clinics

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2021, Volume 76 elocation e3501

Abstract: En | Text: En | PDF: En

OBJECTIVE: To assess the possible factors that influence sleep quality in adolescents with and without chronic immunosuppressive conditions quarantined during the coronavirus disease 2019 (COVID-19) pandemic. METHODS: This cross-sectional study included 305 adolescents with chronic immunocompromised conditions and 82 healthy adolescents. Online surveys were completed, which included questions on socio-demographic data and self-rated healthcare routine during COVID-19 quarantine and the following validated questionnaires: the Pittsburgh Sleep Quality Index (PSQI), Pediatric Quality of Life Inventory 4.0 (PedsQL4.0), and Pediatric Outcome Data Collection Instrument (PODCI). RESULTS: The median current age [14 (10-18) vs. 15 (10-18) years, p=0.847] and frequency of female sex (62% vs. 58%, p=0.571) were similar in adolescents with chronic conditions compared with healthy adolescents. The frequency of poor sleep quality was similar in both groups (38% vs. 48%, p=0.118). Logistic regression analysis, including both healthy adolescents and adolescents with chronic conditions (n=387), demonstrated that self-reported increase in screen time (odds ratio [OR] 3.0; 95% confidence interval [CI] 1.3-6.8; p=0.008) and intrafamilial violence report (OR 2.1; 95% CI 1.2-3.5; p=0.008) were independently associated with poor sleep quality in these adolescents. However, the PODCI global function score was associated with a lower OR for poor sleep quality (OR 0.97; 95% CI 0.94-0.99; p=0.001). Further logistic regression, including only adolescents with chronic conditions (n=305), demonstrated that self-reported increase in screen time (OR 3.1; 95% CI 1.4-6.8; p=0.006) and intrafamilial violence report (OR 2.0; 95% CI 1.2-3.4; p=0.011) remained independently associated with poor quality of sleep, whereas a lower PODCI global function score was associated with a lower OR for sleep quality (OR 0.96; 95% CI 0.94-0.98; p<0.001). CONCLUSION: Self-reported increases in screen time and intrafamilial violence report impacted sleep quality in both healthy adolescents and those with chronic conditions. Decreased health-related quality of life was observed in adolescents with poor sleep quality.

https://doi.org/10.6061/clinics/2021/e3501

15.

Challenges on participation in a cooperative group of childhood renal tumors in Brasil
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Viana, Lucian S.

; Silva, Neimar de Paula

; Balmant, Nathalie V.

; Faria, Paulo A.

; Santos, Marceli O.

; Reis, Rejane S.

; Camargo, Beatriz de

Revista da Associação Médica Brasileira

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- Sobre o periódico
- SciELO Analytics

mar 2020, Volume 66 N. 3 Pages 284 - 289

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO OBJETIVO Crianças com tumores renais incluídas em ensaios clínicos apresentam melhora significativa na sobrevida. No entanto, o envolvimento desses pacientes em ensaios clínicos continua sendo um desafio no Brasil. Nosso objetivo neste estudo é descrever a taxa de aderência e adesão no Grupo Cooperativo Brasileiro para tratamento de Tumor de Wilms (GCBTTW) e identificar barreiras na participação ao protocolo. MÉTODOS Identificamos o número de casos de tumores renais diagnosticados em 105 registros hospitalares de câncer no período de 2001 a 2009. O número total desses casos foi então comparado ao número de casos de tumores renais registrados no GCBTTW provenientes das mesmas unidades hospitalares e durante o mesmo período. Os membros da Sociedade Brasileira de Oncologia Pediátrica foram convidados para completar um questionário com escala do tipo likert com o objetivo de conhecer suas opiniões sobre a importância e as dificuldades na participação em ensaios clínicos de grupos cooperativos. RESULTADOS A aderência de pacientes por hospital variou de 25% a 76% e foi maior na região Sul. A adesão da participação do hospital também variou de acordo com a região (20-31%) e foi maior na região Sudeste. Com relação ao questionário referente à importância da participação em grupos cooperativos, as respostas mostraram concordância de mais de 75% em 10 das 13 afirmações. CONCLUSÃO Nossos resultados demonstraram uma baixa participação em grupos cooperativos no Brasil. Houve variações nas taxas de adesão e aderência de acordo com a região geográfica e unidade hospitalar, o que pode auxiliar em futuros esforços para a melhora dessas taxas. As respostas ao questionário demonstraram que os profissionais entendem a importância da participação em grupos cooperativos.

SUMMARY OBJECTIVE Children with renal tumors included in clinical trials have significantly better outcomes. In Brasil, the enrollment of patients in clinical trials remains challenging. Here we aimed to describe participation accrual in the Brazilian Wilms Tumor Study Group (BWTSG) and to identify barriers to trial registration of children with renal tumors. METHODS We determined the numbers of renal tumor diagnoses in 105 hospital-based cancer registries from 2001-2009. We then compared these totals with the numbers of renal tumor cases registered in the BWTSG from the same hospitals during the same time period. We also invited members of the Brazilian Pediatric Oncology Society to complete a 5-point Likert-type scale questionnaire regarding their opinions of the importance of participation in cooperative group trials. RESULTS The accrual rate of patient participation per hospital varied from 25% to 76%, and was highest in the South region. The accrual rate of hospital participation also varied according to the region (20-31%) and was highest in the Southeast region. For the questionnaire regarding the importance of participation in cooperative groups, the responses showed an agreement of >75% on 10 of the 13 statements. CONCLUSION Our results demonstrated low accrual of participation in a cooperative group trial in Brasil. We identified variations in registration rates according to geographic region and hospital, which may help targeted efforts to increase registration rates. The survey responses demonstrated that colleagues understand the importance of trial participation.

https://doi.org/10.1590/1806-9282.66.3.284 796 downloads

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