RESUMO: O peixe-boi amazônico (Trichechus inunguis) é um mamífero aquático ameaçado de extinção. Apesar disso, poucos estudos investigaram patógenos nessa espécie que podem impactar a saúde animal e humana. O objetivo deste estudo foi avaliar a frequência, distribuição e padrões de suscetibilidade antimicrobiana de Staphylococcus sp. e Escherichia coli pertencentes à microbiota nasal e retal de peixes-bois da Amazônia mantidos em cativeiro no Instituto Nacional de Pesquisas da Amazônia (INPA) (Amazonas, Brasil). Foram utilizados suabes retais e nasais de 44 peixes-boi de diferentes idades. O gênero Staphylococcus foi isolado do swab nasal de 32 (72,7%) animais, sendo que dois indivíduos apresentaram mais de uma espécie de Staphylococcus. S. sciuri foi a espécie mais comumente isolada. A resistência à penicilina foi observada em 13 (40,6%) isolados, sendo mais frequente do que os outros antimicrobianos testados (P = 0,01). Escherichia coli foi isolada dos suabes retais de todos os animais, sendo o filogrupo B1 o mais frequente entre as cepas obtidas (P = 0,0008). Quatro isolados (6,8%) foram positivos para fatores de virulência, três dos quais foram classificados como E. coli enterotoxigênica (ETEC) e um isolado como E. coli enteropatogênica (EPEC). Este é o primeiro estudo a avaliar Staphylococcus spp. e E. coli de amostras de peixe-boi da Amazônia. O estudo revelou colonização nasal por Staphylococcus sp., principalmente S. sciuri, e por isolados diarreiogênicos de E. coli, incluindo cepas resistentes a antimicrobianos. RESUMO peixeboi peixe boi Trichechus inunguis extinção disso humana frequência sp peixesbois peixes bois INPA (INPA Amazonas, Amazonas (Amazonas Brasil. Brasil . Brasil) 4 peixesboi idades 3 72,7% 727 72 7 (72,7% animais S 1 40,6% 406 40 6 (40,6% P 0,01. 001 0,01 0 01 0,01) B 0,0008. 00008 0,0008 0008 0,0008) 6,8% 68 8 (6,8% virulência E ETEC (ETEC EPEC. EPEC (EPEC) spp 72,7 (72,7 40,6 (40,6 00 0,0 0000 0,000 000 6,8 (6,8 (EPEC 72, (72, 40, (40, 0, 0,00 6, (6, (72 (40 (6 (7 (4 (

ABSTRACT: The Amazonian manatee (Trichechusinunguis) is an aquatic mammal threatened with extinction. However, few studies have investigated the pathogens in this species, which may affect both animal and human health. This study aimed to evaluate the frequency, distribution, and patterns of antimicrobial susceptibility of Staphylococcus spp. and Escherichiacoli colonizing the nasal and rectal cavities of Amazonian manatees kept in captivity at the National Institute for Amazonian Research (INPA) in the state of Amazonas, Brazil. Rectal and nasal swabs from 44 manatees of different ages were used in this study. The genus Staphylococcus was isolated from the nasal swabs of 32 (72.7%) animals, with two individuals harboring more than one species of Staphylococcus. S. sciuri was the most commonly isolated species. Resistance to penicillin was observed in 13 (40.6%) isolates, more frequent than the other antimicrobials tested (P = 0.01). E. coli was isolated from the rectal swabs of all animals, with phylogroup B1 being the most frequent among the strains obtained (P = 0.0008). Four isolates (6.8%) were positive for virulence factors, three of which were classified as enterotoxigenicE. coli (ETEC) and one as enteropathogenicE. coli (EPEC). To our knowledge, this is the first study to evaluate Staphylococcus spp. and E. coli in Amazonian manatee samples. This study revealed nasal colonization by Staphylococcus spp., mainly S. sciuri, and diarrheagenicE. coli isolates, including antimicrobial-resistant strains. ABSTRACT Trichechusinunguis (Trichechusinunguis extinction However health frequency distribution spp INPA (INPA Amazonas Brazil 4 3 72.7% 727 72 7 (72.7% animals S 1 40.6% 406 40 6 (40.6% P 0.01. 001 0.01 . 0 01 0.01) E B 0.0008. 00008 0.0008 0008 0.0008) 6.8% 68 8 (6.8% factors enterotoxigenicE ETEC (ETEC enteropathogenicE EPEC. EPEC (EPEC) knowledge samples diarrheagenicE antimicrobialresistant resistant 72.7 (72.7 40.6 (40.6 00 0.0 0000 0.000 000 6.8 (6.8 (EPEC 72. (72. 40. (40. 0. 0.00 6. (6. (72 (40 (6 (7 (4 (

Abstract From the new scenario of globalization and permanent criminal problems, the following research problem arises: how does criminal selectivity manifests in financial totalitarism? Aiming to build an answer, the theory of human criminal law elaborated by Eugenio Raúl Zaffaroni in the book Human Criminal Law and Power in the XXI Century was adopted as a theoretical firework. The developed research belongs to the legal-sociological aspect. Furthermore, the juridical-projective type was adopted as the type of investigation. The study starts from a fundamentally problematizing approach, whose focus is transdisciplinary. As a result achieved, the hypothesis was confirmed that human criminal law emerges as a proposal able to deal with the ills of financial totalitarianism, starting from the following steps: overcoming idealism, constitutionalization and the human being as the center of criminal law.

Resumo Do novo cenário de globalização e de permanentes problemas penais, surge o seguinte problema de pesquisa: de que forma a seletividade penal se manifesta em tempos de totalitarismo financeiro? Almejando construir uma resposta, adotou-se, como marco teórico, a teoria do Direito Penal humano elaborada por Eugenio Raúl Zaffaroni na obra Direito Penal humano e poder no século XXI. A pesquisa desenvolvida pertence à vertente metodológica jurídico-sociológica. Por sua vez, no que concerne ao tipo de investigação, foi adotado o tipo jurídico-projetivo. Ademais, o estudo parte de uma abordagem precipuamente problematizante, cujo foco é transdisciplinar. Como resultado alcançado, confirma-se a hipótese de que o Direito Penal humano surge como proposta apta a lidar com as mazelas do totalitarismo financeiro, partindo dos seguintes passos: a superação do idealismo, a constitucionalização e o ser humano como centro do Direito Penal.

Abstract The number of antral follicles is considered an important fertility trait because animals with a high follicle count (HFC) produce more oocytes and embryos per cycle. Identification of these animals by genetic markers such as single nucleotide polymorphisms (SNPs) can accelerate selection of future generations. The aim of this study was to perform a genome wide association study (GWAS) on Nelore and Angus heifers with HFC and low (LFC) antral follicle counts. The groups HFC and LFC for genotyping were formed based on the average of total follicles (≥ 3 mm) counted in each breed consistently ± standard deviation. A total of 72 Nelore heifers (32 HFC and 40 LFC) and 48 Angus heifers (21 HFC and 27 LFC) were selected and the DNA was extracted from blood and hair bulb. Genotyping was done using the Illumina Bovine HD 770K BeadChip. The GWAS analysis showed 181 and 201 SNPs with genotype/phenotype association (P ≤ 0.01) in Nelore and Angus heifers, respectively. Functional enrichment analysis was performed on candidate genes that were associated with SNPs. A total of 97 genes were associated to the 181 SNPs in the Nelore heifers and the functional analysis identified genes (ROBO1 and SLIT3) in the ROBO-SLIT pathway that can be involved in the control of germ cell migration in the ovary as it is involved in lutheal cell migration and fetal ovary development. In the Angus heifers, 57 genes were associated with the 201 SNPs, highlighting Fribilin 1 (FBN1) gene, involved in regulation of growth factors directly involved in follicle activation and development. In summary, GWAS for Nelore and Angus heifers showed SNPs associated with higher follicle count phenotype. Furthermore, these findings offer valuable insights for the further investigation of potential mechanism involved in follicle formation and development, important for breeding programs for both breeds. (HFC cycle (SNPs generations (GWAS (LFC counts ≥ ( mm deviation 7 32 (3 4 21 (2 2 bulb K BeadChip 18 20 genotypephenotype genotype phenotype P 0.01 001 0 01 respectively 9 ROBO1 ROBO (ROBO SLIT3 SLIT ROBOSLIT development 5 FBN1 FBN (FBN1 gene summary Furthermore breeds 0.0 00 (FBN 0.

Abstract In February 2023, anomalously heavy rainfall caused widespread landslides in the coastal city of São Sebastião (Southeastern Brazil). This report describes the first version of a landslide inventory dataset for this event. The inventory is primarily based on the analysis of aerial images with 10 cm spatial resolution acquired immediately after the event, as well as archive images from Google Earth and PlanetScope. Delimitation of the landslides relied on a comparison of the images along with the area’s Digital Surface Model (DSM) and hydrography. The spatial vector dataset (shapefile and geopackage) contains points representing the landslide’s crowns and polygons indicating the affected area and is openly available in Zenodo. 2023 Southeastern Brazil. Brazil . Brazil) event 1 PlanetScope areas s DSM (DSM hydrography shapefile geopackage Zenodo 202 20 2

Abstract: Cultivar Magnus grano is made up of five genotypes that were selected by coffee growers in the state of Espírito Santo, Brazil. The cultivar shows good adaptation to growing conditions, high yield potential, and the largest beans among the studied genotypes. Abstract Santo Brazil conditions potential

Resumo O objetivo deste trabalho foi avaliar os efeitos da aplicação de diferentes doses de hidrogel e diferentes níveis de irrigação no comportamento morfofisiológico e produtivo de uma cultivar de pimentão, em ambiente protegido. Foram utilizadas quatro doses de hidrogel (0,0, 0,6, 1,2 e 2,4 g por planta) e quatro níveis de irrigação (50, 75, 100 e 125%), com base na evapotranspiração diária do cultivo de pimentão plantado em solo arenoso. A altura, diâmetro do caule e área foliar foram medidos aos 70 e 100 dias. Ao final do experimento, foram estimados o rendimento e a eficiência do uso da água da cultivar de pimentão. O hidrogel associado à irrigação aumenta a área foliar, a produtividade e a eficiência do uso da água de irrigação. O deficit hídrico aplicado (132,8 e 199,26 mm), associado às doses de hidrogel, não afeta morfologicamente as plantas. protegido 0,0, 00 0 (0,0 06 6 0,6 12 1 2 1, 24 4 2, planta 50, 50 (50 75 10 125%, 125 125% , 125%) arenoso altura 7 dias experimento 132,8 1328 132 8 (132, 19926 199 26 199,2 mm, mm mm) plantas 0,0 (0, 0, 5 (5 132, 13 (132 1992 19 199, (0 ( (13 (1

Abstract The objective of this work was to evaluate the effect of the application of different doses of hydrogel and irrigation levels on the morphophysiological and productive behavior of a bell pepper cultivar, in a protected environment. Four doses of hydrogel (0.0, 0.6, 1.2, and, 2.4 g per plant) and four irrigation levels (50, 75, 100, and, 125%) were used, on the basis of the daily evapotranspiration of a bell pepper crop grown in a sandy soil. Height, stem diameter, and leaf area were measured at 70 and 100 days. At the end of the experiment, bell pepper yield and water use efficiency were estimated. Hydrogel associated with irrigation increases leaf area, productivity, and irrigation-water use efficiency. The applied water deficit (132.8 and 199.26 mm), associated with the hydrogel doses, does not affect the plants morphologically. cultivar environment 0.0, 00 0 (0.0 06 6 0.6 12 1 2 1.2 24 4 2. plant 50, 50 (50 75 125% 125 used soil Height diameter 7 10 days experiment estimated productivity irrigationwater 132.8 1328 132 8 (132. 19926 199 26 199.2 mm, mm , mm) morphologically 0.0 (0. 0. 1. 5 (5 132. 13 (132 1992 19 199. (0 ( (13 (1

RESUMO Num cenário de mudanças climáticas, um produtor que decidisse investir em um sistema de integração Lavoura-Floresta, ao invés de investir na produção convencional, se beneficiaria. O presente trabalho, que é um modelo de agricultura de baixa emissão de carbono, teve como objetivo avaliar o efeito do sombreamento e a dependência espacial dos índices da cultura da soja em integração com floresta de eucalipto. O delineamento adotado foi o de blocos ao acaso com seis repetições e tratamentos compostos por diferentes distâncias horizontais sobre eucalipto (30, 34, 38, 42 e 46 m), em duas áreas distintas, uma com presença de eucalipto nas regiões norte e oeste e outra sem a presença do eucalipto na parte norte da área de cultivo da soja. Avaliaram-se os fótons fotossinteticamente ativos em quatro épocas diferentes, o estande de plantas, a altura de plantas e o índice de vegetação após 30 e 60 dias de germinação e por fim a massa de mil grãos e a produtividade. Como resultados, todos atributos apresentaram dependência espacial, exceto produtividade da soja. Como considerações finais, o espaçamento de 34 m entre os eucaliptos promove menor sombreamento. A maior produção média de grãos na área foi encontrada na presença de eucalipto nas laterais oeste e norte da área de cultivo. climáticas LavouraFloresta, LavouraFloresta Lavoura Floresta, Floresta Lavoura-Floresta convencional beneficiaria trabalho carbono 30, (30 38 4 m, , m) distintas Avaliaramse Avaliaram 3 6 resultados finais (3 (

ABSTRACT In a climate change scenario, a producer who decides to invest in a Crop-Forest integration system, instead of investing in conventional production, benefits. The objective the present work, which is a low carbon emission agriculture model, aimed to evaluate the effect of shading and the spatial dependence of soybean crop indices in integration with eucalyptus forest. The design adopted was that of randomized blocks with six replications and treatments composed of different horizontal distances about eucalyptus (30, 34, 38, 42 and 46 m), in two distinct areas, one with the presence of eucalyptus forest in the north and west phase and another one without the presence of eucalyptus in the northern part of the soybean cultivation area. Evaluated the photosynthetically active photons at four different times, the plant stand, plant height, and the vegetation index after 30 and 60 days of germination and finally the mass of a thousand grains and productivity. As a result, all attributes showed spatial dependence, except soybean productivity. As final considerations, the spacing of 34 m between the eucalyptus trees promote less shading. The highest average grain production in the area was found in the presence of eucalyptus on the west and north sides of the cultivation area. scenario CropForest Crop Forest system benefits work model 30, (30 38 4 m, , m) areas times stand height 3 6 productivity result considerations (3 (

RESUMO Introdução: a medição da gravidade das lesões traumáticas é essencial para prever os desfechos clínicos. Enquanto o Injury Severity Score (ISS) tem limitações ao atribuir pontuações às lesões no mesmo local, o New Injury Severity Score (NISS) corrige esse problema ao considerar as três lesões mais graves independentemente da região corporal. Este estudo visa entender o perfil clínico-epidemiológico dos pacientes traumatizados, comparando a eficácia das escalas para prever mortalidade. Métodos: estudo descritivo, observacional e retrospectivo utilizando registros de pacientes submetidos à toracotomia no Hospital das Clínicas da Universidade Federal do Triângulo Mineiro entre 2000 e 2019. Dados demográficos, mecanismos de lesão, órgãos afetados, tempo de internação e mortalidade foram analisados. A gravidade das lesões foi avaliada usando o ISS e NISS, e as análises estatísticas foram conduzidas no MedCalc e SigmaPlot. Resultados: Foram avaliados 101 pacientes, em média com 29,6 anos, sendo 86,13% homens. A média da internação foi de 10,9 dias e a taxa de mortalidade foi de 28,7%. A análise da curva ROC revelou uma sensibilidade de 68,97%, especificidade de 80,56% e área sob a curva de 0,837 para o ISS, e 58,62%, 94,44% e 0,855 para o NISS, respectivamente. O índice de Youden indicou 0,49 para o ISS e 0,53 para o NISS. Conclusão: o estudo demonstrou semelhante eficácia entre o NISS e o ISS na previsão de mortalidade. Esses resultados geram implicações importantes na aplicação dessas escalas no ambiente hospitalar. É essencial que os profissionais conheçam tais escalas para aplica-las adequadamente no contexto de cada paciente. Introdução clínicos (ISS local (NISS corporal clínicoepidemiológico clínico epidemiológico traumatizados Métodos descritivo 200 2019 demográficos lesão afetados analisados SigmaPlot Resultados 10 296 29 6 29, anos 8613 86 13 86,13 homens 109 9 10, 287 28 7 28,7% 6897 68 97 68,97% 8056 80 56 80,56 0837 0 837 0,83 5862 58 62 58,62% 9444 94 44 94,44 0855 855 0,85 respectivamente 049 49 0,4 053 53 0,5 Conclusão hospitalar aplicalas aplica las paciente 20 201 1 2 861 8 86,1 28,7 689 68,97 805 5 80,5 083 83 0,8 586 58,62 944 4 94,4 085 85 04 0, 05 86, 28, 68,9 80, 08 58,6 94, 68, 58,

ABSTRACT Introduction: measuring the severity of traumatic injuries is crucial for predicting clinical outcomes. Whereas the Injury Severity Score (ISS) has limitations in assigning scores to injuries at the same site, the New Injury Severity Score (NISS) corrects for this problem by taking into account the three most severe injuries regardless of the region of the body. This study seeks to comprehend the clinical and epidemiological profile of trauma patients while comparing the effectiveness of scales for predicting mortality. Methods: a descriptive, observational and retrospective study using records of patients who underwent thoracotomy at the Hospital das Clínicas of the Federal University of Triângulo Mineiro between 2000 and 2019. Demographic data, mechanisms of injury, affected organs, length of stay and mortality were analyzed. Injury severity was assessed using the ISS and NISS, and statistical analyses were conducted using MedCalc and SigmaPlot. Results: 101 patients were assessed, on average 29.6 years old, 86.13% of whom were men. The average duration of hospitalization was 10.9 days and the mortality rate was 28.7%. The ROC curve analysis revealed a sensitivity of 68.97%, specificity of 80.56% and area under the curve of 0.837 for the ISS, and 58.62%, 94.44% and 0.855 for the NISS, respectively. The Youden index was 0.49 for the ISS and 0.53 for the NISS. Conclusion: the study demonstrated comparable efficacy of NISS and ISS in predicting mortality. These findings hold significance in the hospital setting. Professionals must be familiar with these scales to utilize them competently for each patient. Introduction outcomes (ISS site (NISS body Methods descriptive 200 2019 data injury organs analyzed SigmaPlot Results 10 296 29 6 29. old 8613 86 13 86.13 men 109 9 10. 287 28 7 28.7% 6897 68 97 68.97% 8056 80 56 80.56 0837 0 837 0.83 5862 58 62 58.62% 9444 94 44 94.44 0855 855 0.85 respectively 049 49 0.4 053 53 0.5 Conclusion setting patient 20 201 1 2 861 8 86.1 28.7 689 68.97 805 5 80.5 083 83 0.8 586 58.62 944 4 94.4 085 85 04 0. 05 86. 28. 68.9 80. 08 58.6 94. 68. 58.

RESUMO A doença de Madelung é caracterizada pelo acúmulo simétrico e difuso de tecido adiposo com crescimento tumoral lento e progressivo. Neste relato de caso, um paciente portador dessa síndrome foi atendido no Hospital das Clínicas, em Recife, PE, com o objetivo de realizar uma redução do conteúdo lipomatoso através de lipectomia. O paciente apresentava volumosas massas de tecido adiposo elástico ao redor do pescoço e região supraclavicular e a proposta terapêutica consistiu em uma cirurgia em dois tempos, com lipoaspiração e lipectomia cervical anterior, seguida de lipoaspiração e lipectomia cervical posterior. Antes da cirurgia, foi solicitado um parecer cardiológico, que indicou um risco intermediário, mas não contraindicou o procedimento. Após 4 dias da cirurgia, o paciente apresentou equimoses e edema periférico na ferida operatória cervical, porém estava assintomático. As técnicas de lipectomia e lipoaspiração são consideradas os métodos de tratamento mais eficazes para a doença de Madelung. No entanto, a escolha da cirurgia deve ser baseada em uma avaliação abrangente da gravidade da doença, localização da massa e expectativas do paciente, uma vez que ambas as técnicas possuem vantagens e desvantagens. progressivo caso Clínicas Recife PE tempos anterior posterior cardiológico intermediário procedimento assintomático entanto desvantagens

ABSTRACT Madelung’s disease is characterized by the symmetric and diffuse accumulation of adipose tissue with slow and progressive tumor growth. In this case report, a patient with this syndrome was treated at Hospital das Clínicas, in Recife, PE, to reduce the lipomatous content through a lipectomy. The patient presented large masses of elastic adipose tissue around the neck and supraclavicular region and the therapeutic proposal consisted of a two-stage surgery, with liposuction and anterior cervical lipectomy, followed by liposuction and posterior cervical lipectomy. Before surgery, a cardiological opinion was requested, which indicated an intermediate risk but did not contraindicate the procedure. Four days after surgery, the patient presented bruises and peripheral edema in the cervical surgical wound but was asymptomatic. Lipectomy and liposuction techniques are considered the most effective treatment methods for Madelung disease. However, the choice of surgery should be based on a comprehensive assessment of the severity of the disease, location of the mass, and patient expectations, as both techniques have advantages and disadvantages. Madelungs s growth report Clínicas Recife PE lipectomy twostage two stage requested procedure asymptomatic However mass expectations disadvantages

RESUMO A abobrinha pode apresentar diferentes respostas à presença de sais nas suas fases fenológicas e a oferta de K pode interferir na dinâmica de alocação de assimilados, maximizando a produção. Neste sentido, objetivou-se avaliar o efeito de estratégias de irrigação com água salobra em diferentes estágios fenológicos sob adubação potássica na produtividade e qualidade de frutos de abobrinha italiana. Adotou-se o delineamento inteiramente aleatorizado em esquema fatorial 4 x 3, sendo aplicação de estratégias de irrigação (S1, S2, S3 e S4) com base na fenologia da cultura utilizando duas condutividades elétricas (ECw) (W1: 0,3 dS/m e W2: 2,6 dS/m), (S1= W1 em todo o ciclo da cultura; S2 = W1 até o florescimento e início da frutificação e W2 nas fases de plena frutificação e colheita; S3 = W2 no florescimento e início da frutificação e W1 nas fases de plena frutificação e colheita; S4 = W1 até o florescimento e início da frutificação, W2 na fase de plena frutificação e W1 na colheita), com três doses de potássio (K1= 0, K2= 7,5 e K3= 15 g/planta), e quatro repetições. O estresse salino em qualquer fase reduz a qualidade dos frutos, além de ocasionar menor produtividade e eficiência no uso da água. As doses de 50 (K2) e 100% (K3) de potássio proporcionaram menor produtividade e eficiência no uso da água. São necessárias maiores análises e pesquisas com intuito de determinar a dose ideal para cultivos em condições similares às do presente estudo. assimilados produção sentido objetivouse objetivou se italiana Adotouse Adotou 3 S1, S1 S (S1 ECw (ECw W (W1 03 0 dSm dS m 26 2 6 2, dS/m, , dS/m) S1= colheita colheita, colheita) K1= K1 (K1 K2 75 7 5 7, K3 1 g/planta, gplanta g/planta g planta g/planta) repetições (K2 100 (K3 estudo (S (W (K 10

ABSTRACT Zucchini may present different responses to the presence of salts in its phenological phases, and the supply of potassium can interfere with assimilate allocation dynamics, maximizing production. In this context, the aim of this study was to evaluate the effect of brackish water irrigation strategies at different phenological stages under potassium fertilization on the yield and quality of italian zucchini fruits. A completely randomized design was adopted in a 4 x 3 factorial scheme, with the application of different irrigation strategies (S1, S2, S3 and S4) based on crop phenology using two electrical conductivities (ECw) (W1: 0.3 dS/m; W2: 2.6 dS/m). (S1= W1 throughout the crop cycle; S2= W1 up to flowering and early fruiting, and W2 during the full fruiting and harvesting phases; S3= W2 during flowering and early fruiting, and W1 during full fruiting and harvesting; S4= W1 up to flowering and early fruiting, W2 during the full fruiting phase, and W1 during harvesting), with three potassium doses (K1= 0, K2= 7.5, and K3= 15 g/plant), and four replications. Saline stress at any stage reduces fruit quality, in addition to resulting in lower productivity and water use efficiency. Doses of 50 (K2) and 100% (K3) potassium provided lower productivity and water use efficiency. Further analyses and research are required to determine the ideal dose for crops under similar conditions of this study. phases dynamics production context fruits scheme S1, S1 S (S1 S2 S4 ECw (ECw W (W1 03 0 0. dS/m dSm dS m 26 2 6 2. dS/m. . dS/m) S1= cycle phase harvesting, , harvesting) K1= K1 K (K1 K2 75 7 5 7.5 K3 1 g/plant, gplant g/plant g plant g/plant) replications efficiency (K2 100 (K3 (S (W (K 7. 10

Abstract With the development of in vitro technologies, embryos can be produced using oocytes retrieved directly from the ovaries, i.e., regardless of ovulation. This has allowed the use of different animal categories as oocyte donors, including prepubertal cattle. The advantages of using this strategy to shorten the generation interval and accelerate genetic gain over time were soon recognized, and the first offspring generated using oocytes collected from calves were born in the early 1990s. Nevertheless, embryo production from calves and prepubertal heifers remains a challenge. The oocytes collected before puberty present low in vitro developmental potential, and the subsequent blastocyst rates are consistently lower than those from pubertal females. The acquisition of developmental competence by the oocytes occurs progressively throughout the prepubertal period, which can be subdivided into an early, intermediate, and late prepubertal (or peripubertal) phases, each characterized by different physiological and endocrine features. Therefore, embryo yield increases with age but will only achieve its maximum after puberty. The most common strategy to improve oocyte developmental potential before puberty is the use of gonadotrophic stimulation prior to oocyte retrieval. The results with superstimulation, however, vary among studies, depending on the source, dose, and length of FSH treatment, as well as the age and breed of the donors. The use of calves and prepubertal heifers as oocyte donors should also consider the possible impacts of the oocyte retrieval technique (LOPU or OPU) and the use of exogenous hormones on their subsequent fertility and productive life. technologies ovaries ie i e i.e. ovulation cattle recognized 1990s s Nevertheless challenge females period intermediate peripubertal phases features Therefore superstimulation however studies source dose treatment LOPU OPU life i.e

Resumo Questionando algumas narrativas sobre o pioneirismo e as inovações conceituais do grupo Modernidade/Colonialidade, o objetivo deste artigo é discutir algumas formulações teóricas de Celso Furtado que se aproximam do que se entende atualmente nas ciências sociais latino-americanas como uma análise da “colonialidade” e que são anteriores ao trabalho do grupo. Discutindo a teoria da dependência desenvolvida pelo autor nos anos de 1970, examinamos os seus elementos de crítica ao eurocentrismo, à racionalidade instrumental, à ideologia moderna do progresso e às formas de vida associadas à civilização industrial. ModernidadeColonialidade Modernidade Colonialidade Modernidade/Colonialidade latinoamericanas latino americanas colonialidade “colonialidade 1970 eurocentrismo instrumental industrial 197 19 1

Abstract Questioning some narratives about the pioneering spirit and conceptual innovations of the Modernity/Coloniality group, the aim of this article is to discuss some of Celso Furtado's theoretical formulations that are close to what is currently understood in Latin American social sciences as an analysis of "coloniality" and that predate the group's work. Discussing the theory of dependency developed by the author in the 1970s, we examine its elements of criticism of Eurocentrism, instrumental rationality, the modern ideology of progress and the ways of life associated with industrial civilization. ModernityColoniality Modernity Coloniality group Furtados Furtado s coloniality "coloniality groups work 1970s Eurocentrism rationality civilization

Abstract The aim of this study was to evaluate the expression of the EZH2 protein and describe the clinical and microscopic characteristics of adenoid cystic carcinoma (ACC) and pleomorphic adenoma (PA). The study included 16 ACC cases and 12 PA. All ACC and PA cases were positive for EZH2 and the ACC samples showed significantly higher EZH2 expression. The clinical and microscopic covariates were described in relation to EZH2 staining in ACC samples. The highest mean values of EZH2 were observed in cases with local metastasis, recurrence, perineural invasion, and predominantly cribriform growth pattern without solid areas. EZH2 is a potential marker of malignancy. EZH (ACC . (PA) 1 metastasis recurrence invasion areas malignancy (PA

RESUMO A exploração das potencialidades das espécies Amazônicas, como o Guadua weberbaueripopularmente conhecido como bambu, é verificada em diversos segmentos. Tendo seu grande potencial na aplicação para a construção civil, ainda pode ser maximizado com a aplicação da nanotecnologia. Este estudo tem como objetivo verificar as pesquisas de aplicações da fibra de bambu Guadua weberbaueri, para a construção civil, nos últimos cinco anos. Através de quatro bases de dados indexadas de estudos, aplicando para seis descritores, e os catalogando, ao longo de suas áreas de exploração e ano de vinculação, foi possível tecer os dados e resultados obtidos. Esses resultados apontaram para 10 estudos que utilizaram a espécie, sendo que esses estudos eram, majoritariamente, na área de caracterização das propriedades biológicas ou físico-químicas e nenhum corresponde à área de construção civil. Também percebeu que ao longo dos últimos cinco anos, a curva de estudos realizados é crescente. Assim, verificou-se a carência na exploração do potencial, tanto da espécie Guadua weberbaueri, como da sua fibra, como componente estrutural, dentro da engenharia civil. Amazônicas segmentos civil nanotecnologia weberbaueri anos descritores catalogando vinculação obtidos 1 eram majoritariamente físicoquímicas físico químicas crescente Assim verificouse verificou se estrutural

ABSTRACT The exploration of the potential of Amazonian species, such as Guadua weberbaueri, popularly known as bamboo, is verified in several segments. Having its great potential in the application for civil construction, it can still be maximized with the application of nanotechnology. The objective of this study is to verify the research on applications of Guadua weberbaueri bamboo fiber for civil construction in the last five years. Through four indexed databases of studies, applying to six descriptors, and cataloguing them, throughout their areas of exploration and year of affiliation, it was possible to weave the data and results obtained. These results pointed to 10 studies that used the species, and these studies were mostly in the area of characterization of biological or physicochemical properties and none corresponded to the area of civil construction. He also noticed that over the last five years, the curve of studies carried out has been increasing. Thus, there was a lack of exploration of the potential of both the Guadua weberbaueri species and its fiber as a structural component within civil engineering. segments nanotechnology years descriptors them affiliation obtained 1 increasing Thus engineering

Abstract Cereus jamacaru DC. (Cactaceae) is used in folk medicine for treating pain and inflammation. However, the therapeutic potential of C. jamacaru extracts has not been assessed experimentally. This study aimed to characterize the effect of both aqueous (CAECJ) and ethanolic (CEECJ) extracts of C. jamacaru in mouse models of pain and inflammation. CAECJ and CEECJ were chemically characterized by qualitative methods. Toxicity of extracts was evaluated in vitro against J774.A1 macrophages and in vivo by monitoring mice for 14 days following a single oral treatment at 2000 mg/kg. The antinociceptive activity of the extracts was assessed in models of pain in mice: acetic acid-induced writhing test, formalin test, hot plate test, and glutamate-induced nociception assay. The anti-inflammatory activity of the extracts was assessed following zymosan-induced peritonitis and in the model of arthritis induced by Complete Freund’s Adjuvant (CFA). Phytochemical analyses revealed alkaloids, condensed tannins, flavonoids, and anthraquinones in both extracts; saponins were present in CEECJ only. Neither extract was cytotoxic in vitro or induced toxicity in mice. Both extracts reduced nociception in all models of nociception without impairing motor function. Both extracts reduced leucocyte migration during experimental peritonitis and reduced paw edema during experimental arthritis. The effects of the extracts can be both due to anti-inflammatory and centrally-mediated mechanisms. This paper corroborates the traditional use of C. jamacaru extracts and demonstrates their therapeutic potential in the development of new analgesic and anti-inflammatory drugs with a good safety profile. DC Cactaceae (Cactaceae inflammation However C experimentally (CAECJ (CEECJ methods J774A1 JA J774 A1 J A J774.A 1 200 mgkg mg kg mg/kg acidinduced acid test glutamateinduced glutamate assay antiinflammatory anti inflammatory zymosaninduced zymosan Freunds Freund s CFA. CFA . (CFA) alkaloids tannins flavonoids only function centrallymediated centrally mediated mechanisms profile J774A J77 20 (CFA J7 2