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Joint statement on evidence-based practices in mechanical ventilation: suggestions from two Brazilian medical societies
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Ferreira, Juliana Carvalho

; Vianna, Arthur Oswaldo de Abreu

; Pinheiro, Bruno Valle

; Maia, Israel Silva

; Baldisserotto, Sérgio Vasconcellos

; Isola, Alexandre Marini

; Cavalcanti, Alexandre Biasi Gama, Ana Maria Casati Nogueira da Rocha, Angelo Roncalli Miranda Oliveira, Antonio Gonçalves de Serpa Neto, Ary Farias, Augusto Manoel de Carvalho Orlando, Bianca Rodrigues Esteves, Bruno da Costa Mazza, Bruno Franco Silveira, Camila de Freitas Martins Soares Carvalho, Carlos Roberto Ribeiro de Toufen Junior, Carlos Barbas, Carmen Silvia Valente Teixeira, Cassiano Silveira, Débora Dutra da Medeiros, Denise Machado Parolo, Edino Costa, Eduardo Leite Vieira Caser, Eliana Bernadete Oliveira, Ellen Pierre de Banholzer, Eric Grieger Carvalho, Erich Vidal Amorim, Fabio Ferreira Saddy, Felipe Gonçalves, Fernanda Alves Ferreira Galas, Filomena Regina Barbosa Gomes Zanatta, Giovanna Carolina Gardini Silva, Gisele Sampaio Westphal, Glauco Adrieno Matos, Gustavo Faissol Janot de Souza, João Claudio Emmerich de Silva Junior, João Manoel Valiatti, Jorge Luis dos Santos Nascimento Junior, José Ribamar do Rocco, Jose Rodolfo Hajjar, Ludhmila Abrahão Forgiarini Junior, Luiz Alberto Malbuisson, Luiz Marcelo Sá Holanda, Marcelo Alcantara Amato, Marcelo Britto Passos Park, Marcelo Oliveira, Marco Antonio da Rosa e Reis, Marco Antonio Soares Tavares, Marcos Soares Souza, Mario Henrique Dutra de Damasceno, Marta Cristina Pauleti Lira-Batista, Marta Maria da Silva Pattacini, Max Morais Assunção, Murillo Santucci Cesar de Oliveira, Neymar Elias de Franzosi, Oellen Stuani Rocco, Patricia Rieken Macedo Caruso, Pedro Silva, Pedro Leme Mendes, Pedro Vitale Duarte, Pericles Almeida Delfino Santa Neto, Renato Fabio Alberto Della Rodrigues, Ricardo Goulart Cordioli, Ricardo Luiz Palazzo, Roberta Fittipaldi Goldwasser, Rosane Pinheiro, Sabrina dos Santos Justino, Sandra Regina Nemer, Sergio Nogueira Oliveira, Vanessa Martins de Silva, Vinicius Zacarias Maldaner da Nedel, Wagner Luis Bellissimo-Rodrigues, Wanessa Teixeira Oliveira Filho, Wilson de

Critical Care Science

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2025, Volume 37 elocation e20250242en

Abstract: En | Text: En | PDF: En

ABSTRACT Mechanical ventilation can be a life-saving intervention, but its implementation requires a multidisciplinary approach, with an understanding of its indications and contraindications due to the potential for complications. The management of mechanical ventilation should be part of the curricula during clinical training; however, trainees and practicing professionals frequently report low confidence in managing mechanical ventilation, often seeking additional sources of knowledge. Review articles, consensus statements and clinical practice guidelines have become important sources of guidance in mechanical ventilation, and although clinical practice guidelines offer rigorously developed recommendations, they take a long time to develop and can address only a limited number of clinical questions. The Associação de Medicina Intensiva Brasileira and the Sociedade Brasileira de Pneumologia e Tisiologia sponsored the development of a joint statement addressing all aspects of mechanical ventilation, which was divided into 38 topics. Seventy-five experts from all regions of Brazil worked in pairs to perform scoping reviews, searching for publications on their specific topic of mechanical ventilation in the last 20 years in the highest impact factor journals in the areas of intensive care, pulmonology, and anesthesiology. Each pair produced suggestions and considerations on their topics, which were presented to the entire group in a plenary session for modification when necessary and approval. The result was a comprehensive document encompassing all aspects of mechanical ventilation to provide guidance at the bedside. In this article, we report the methodology used to produce the document and highlight the most important suggestions and considerations of the document, which has been made available to the public in Portuguese.

https://doi.org/10.62675/2965-2774.20250242-en

Proton spectroscopy: a simple and useful tool in the investigation of mitochondrial disease
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NASSIF, Daniel Venturino

; VASCONCELLOS, Luiz Felipe Rocha

Arquivos de Neuro-Psiquiatria

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may 2022, Volume 80 N. 5 Pages 543 - 544

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/0004-282x-anp-2021-0422

Referral to immediate postoperative care in an intensive care unit from the perspective of anesthesiologists, surgeons, and intensive care physicians: a cross-sectional questionnaire
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Silva Jr, João Manoel

; Katayama, Henrique Tadashi Lopes, Felipe Manuel Vasconcellos Toledo, Diogo Oliveira Amendola, Cristina Prata Oliveira, Fernanda dos Santos Andraus, Leusi Magda Romano Carmona, Maria José C. Lobo, Suzana Margareth Malbouisson, Luiz Marcelo Sá

Brazilian Journal of Anesthesiology

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jun 2021, Volume 71 N. 3 Pages 265 - 270

Abstract: En | Text: En | PDF: En

Abstract Introduction and objective Due to the high cost and insufficient offer, the request for Intensive Care (ICU) beds for postoperative recovery needs adequate criteria. Therefore, we studied the characteristics of patients referred to postoperative care at an ICU from the perspective of anesthesiologists, surgeons, and intensive care physicians. Methods A questionnaire on referrals to postoperative intensive care was applied to physicians at congresses in Brazil. Anesthesiologists, surgeons, and intensive care physicians who agreed to fill out the questionnaire were included. The questionnaire consisted of hypothetical clinical scenarios and cases for participants to choose which would be the priority for referral to the ICU. Results 360 physicians participated in the study, with median time of 10 (5-18) years after graduation. Of the interviewees, 36.4% were anesthesiologists, 30.0% surgeons, and 33.6% intensive care physicians. We found that anesthesiologists were more conservative, and surgeons less conservative in ICU referrals. As to patients with risk of bleeding, 75.0% of the surgeons would refer them to the ICU, in contrast with 52.1% of the intensive care physicians, and 43.5% of the anesthesiologists (p< 0.001). As to elderly persons with limited reserve, 62.0% of the surgeons would refer them to the ICU, in contrast with 47.1% of the intensive care physicians, and 22.1% of the anesthesiologists (p< 0.001). As to patients with risk of respiratory complications, 64.5% of the surgeons would recommend the ICU, versus 43.0% of the intensive care physicians, and 32.1% of the anesthesiologists (p< 0.001). Intensive care physicians classified priorities better in indicating ICU, and the main risk indicator was the ASA physical status in all specialties (p< 0.001). There was no agreement among the specialties and surgeries on prioritizing post-operative intensive care. Conclusion Anesthesiologists, surgeons, and intensive care physicians presented different perspectives on postoperative referral to the ICU.

https://doi.org/10.1016/j.bjane.2021.03.025

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Silva Jr, João Manoel

Brazilian Journal of Anesthesiology

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2021, N. ahead

Abstract: En | Text: En | PDF: En

https://doi.org/10.1016/j.bjane.2021.03.025 12 downloads

Symptoms of depression in patients with mild cognitive impairment in Parkinson's disease
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Malak, Ana Lara Soares Blum Vasconcellos, Luiz Felipe Pereira, João Santos Greca, Denise Vieira Cruz, Manuela Alves, Heloisa Veiga Dias Sptiz, Mariana Charchat-Fichman, Helenice

Dementia & Neuropsychologia

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jun 2017, Volume 11 N. 2 Pages 145 - 153

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Investigar os sintomas depressivos mais frequentes e sua associação com a cognição de indivíduos com doença de Parkinson (DP) e declínio cognitivo leve (DCL) Métodos: Foram avaliados 48 pacientes com DP e 44 Controles (GC), com idade entre 50 e 80 anos e escolaridade superior a 4 anos, todos com DCL e sem diagnóstico de depressão. Pacientes e controles foram pareados quanto à idade, escolaridade e pontuação do Mini Exame do Estado Mental (MEEM). Os participantes foram submetidos à avaliação clínica com neurologista seguida de avaliação neuropsicológica com os instrumentos MEEM, Teste do Desenho do Relógio, Teste de Fluência Verbal Semântica e Fonêmica, Teste de Memória de Figuras (FMT), Teste Stroop de Cores e Palavras, Teste das Trilhas (TMT), Span de Dígitos WAIS III, Teste de Aprendizagem Auditivo-Verbal de Rey (RAVLT), Teste de Organização Visual de Hooper e Inventário de Depressão de Beck (BDI). Resultados: Os sintomas depressivos mais frequentes no grupo DP foram dificuldade para trabalhar, fatigabilidade e distúrbios do sono, sendo este comum ao grupo controle. A pontuação do BDI correlacionou-se negativamente com aprendizagem e memória de reconhecimento em ambos os grupos. Neste estudo, a memória episódica, avaliada pelos testes FMT e RAVLT, apresentou-se como a função cognitiva com maior comprometimento. Conclusão: Alguns sintomas depressivos prevalentes nos Parkinsonianos com DCL podem ser atribuídos à DP, dificultando o diagnóstico diferencial.

ABSTRACT Objective: To investigate the most frequent depressive symptoms and their association with cognition in Parkinson's disease (PD) patients with mild cognitive impairment (MCI). Methods: 48 patients with PD and 44 controls (CG), aged between 50 and 80 years and with at least 4 years of formal education, all with MCI and none diagnosed with depression, were assessed. Patients and controls were matched for age, education, and Mini-Mental State Examination (MMSE) score. Participants underwent clinical evaluation with a neurologist followed by neuropsychological assessment employing the instruments: MMSE, Clock Drawing Test, Verbal Fluency Test (semantic and phonemic), Figures Memory Test (FMT), Stroop Test, Trail Making Test, Digit Span (WAIS III), Rey Auditory Verbal Learning Test (RAVLT), Hooper Visual Organization Test, and Beck Depression Inventory (BDI). Results: The most frequent depressive symptoms in the PD group were: difficulty working, fatigue and sleep disorders (the latter also being present in CG). BDI score correlated negatively with learning and recognition memory in both groups. Episodic memory, evaluated by the FMT and RAVLT tests, was the cognitive function showing greatest impairment. Conclusion: Some of the depressive symptoms observed in PD patients with MCI seem to be attributable to complications of PD, while others are common to both PD and MCI, making differential diagnoses complex but crucial.

https://doi.org/10.1590/1980-57642016dn11-020007 2530 downloads

Percheron thalamopeduncular syndrome with cervical dystonia: A case report
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Vasconcellos, Luiz Felipe Tiel, Chan Sudo, Felipe Kenji Moreira, Denise Madeira Engelhardt, Eliasz

Dementia & Neuropsychologia

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dec 2016, Volume 10 N. 4 Pages 365 - 369

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Infartos talâmicos bilaterais são em geral ocasionados por oclusão da "Artéria de Percheron" (AdP). A síndrome talamopeduncular está entre as apresentações clínicas mais comuns da oclusão da AdP. Um homem de 59 anos apresentou rebaixamento abrupto do nível de consciência. Após algumas semanas, ao recobrar a consciência, apresentava anormalidades oculomotoras, marcha atáxica, distonia cervical e alterações cognitivas e comportamentais. A imagem por ressonância magnética evidenciou infartos talâmico, subtalâmico, mamilar e mesencefálico. O quadro clínico foi sugestivo de síndrome talamopeduncular. Além da presença de comprometimento cognitivo e transtornos de comportamento, estava presente distonia cervical, que pode resultar da interrupção das interconexões entre gânglios da base, tálamo, subtálamo, mesencéfalo e cerebelo.

ABSTRACT Bilateral thalamic infarctions are usually caused by occlusion of the "Artery of Percheron" (AoP). Thalamopeduncular syndrome is among the most common presentations of AoP occlusion. A 59-year-old male presented abrupt decreased level of consciousness. After several weeks, on regaining consciousness, he exhibited oculomotor abnormalities, ataxic gait, cervical dystonia, and cognitive and behavioral changes. Magnetic resonance imaging disclosed thalamic, subthalamic, mammillary and midbrain infarction. Clinical features suggestive of bilateral thalamopeduncular syndrome were identified. Besides the presence of cognitive impairment and behavioral symptoms, cervical dystonia was evident, possibly resulting from interruption of the interconnections among basal ganglia, thalamus, subthalamus, midbrain and cerebellum.

https://doi.org/10.1590/s1980-5764-2016dn1004019 1631 downloads

ERICA: leisure-time physical inactivity in Brazilian adolescents
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Cureau, Felipe Vogt Silva, Thiago Luiz Nogueira da Bloch, Katia Vergetti Fujimori, Elizabeth Belfort, Dilson Rodrigues Carvalho, Kênia Mara Baiocchi de Leon, Elisa Brosina de Vasconcellos, Mauricio Teixeira Leite de Ekelund, Ulf Schaan, Beatriz D

Revista de Saúde Pública

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2016, Volume 50 Suppl. 1 elocation 4s

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO OBJETIVO Avaliar a prevalência de inatividade física no lazer em adolescentes brasileiros e sua associação com variáveis geográficas e sociodemográficas. MÉTODOS A amostra foi composta por 74.589 adolescentes participantes do Estudo de Riscos Cardiovasculares em Adolescentes (ERICA). Esse estudo transversal de base escolar com abrangência nacional envolveu adolescentes brasileiros de 12 a 17 anos de municípios com mais de 100 mil habitantes. A prevalência de inatividade física no lazer foi categorizada de acordo com o volume de prática semanal (< 300; zero min). As prevalências foram estimadas para o total da amostra analisada e por sexo. Modelos de regressão de Poisson foram utilizados para avaliar fatores associados. RESULTADOS A prevalência de inatividade física no lazer foi de 54,3% (IC95% 53,4-55,2), superior no sexo feminino (70,7%, IC95% 69,5-71,9) comparado ao masculino (38,0%, IC95% 36,7-39,4). Mais de um quarto dos adolescentes (26,5%, IC95% 25,8-27,3) referiram não praticar atividade física no lazer, condição mais prevalente no sexo feminino (39,8%, IC95% 38,8-40,9) que no masculino (13,4%, IC95% 12,4-14,4). Para o sexo feminino, as variáveis que se associaram à inatividade física foram: residir nas regiões Nordeste (RP = 1,13, IC95% 1,08-1,19), Sudeste (RP = 1,16, IC95% 1,11-1,22) e Sul (RP = 1,12, IC95% 1,06-1,18); ter 16-17 anos (RP = 1,12, IC95% 1,06-1,15); e pertencer à classe econômica mais baixa (RP = 1,33, IC95% 1,20-1,48). Os mesmos fatores, exceto residir no Sudeste e Sul, também associaram-se com não praticar atividade física no lazer no mesmo grupo. No sexo masculino, além da região, ser mais velho (p < 0,001) e declarar-se indígena (RP = 0,37, IC95% 0,19-0,73) associaram-se à prevalência de não praticar atividade física no lazer. CONCLUSÕES A prevalência de inatividade física no lazer em adolescentes brasileiros é elevada, apresenta variações regionais e está associada à idade e ao baixo nível socioeconômico. Especial atenção deve ser dada às meninas e aos que não praticam nenhuma atividade física no lazer, a fim de que estes possam adotar estilo de vida mais ativo.

ABSTRACT OBJECTIVE To evaluate the prevalence of leisure-time physical inactivity in Brazilian adolescents and their association with geographical and sociodemographic variables. METHODS The sample was composed by 74,589 adolescents participating in the Study of Cardiovascular Risks in Adolescents (ERICA). This cross-sectional study of school basis with national scope involved adolescents aged from 12 to 17 years in Brazilian cities with more than 100 thousand inhabitants. The prevalence of leisure-time physical inactivity was categorized according to the volume of weekly practice (< 300; 0 min). The prevalences were estimated for the total sample and by sex. Poisson regression models were used to assess associated factors. RESULTS The prevalence of leisure-time physical inactivity was 54.3% (95%CI 53.4-55.2), and higher for the female sex (70.7%, 95%CI 69.5-71.9) compared to the male (38.0%, 95%CI 36.7-39.4). More than a quarter of adolescents (26.5%, 95%CI 25.8-27.3) reported not practicing physical activity in the leisure time, a condition more prevalent for girls (39.8%, 95%CI 38.8-40.9) than boys (13.4%, 95%CI 12.4-14.4). For girls, the variables that were associated with physical inactivity were: reside in the Northeast (RP = 1.13, 95%CI 1.08-1.19), Southeast (RP = 1.16, 95%CI 1.11-1.22) and South (RP = 1.12, 95%CI 1.06-1.18); have 16-17 years (RP = 1.06, 95%CI 1.12-1.15); and belong to the lower economic class (RP = 1.33, 95%CI 1.20-1.48). The same factors, except reside in the Southeast and South, were also associated with not practicing physical activity in the leisure time for the same group. In males, as well as the region, being older (p < 0.001) and declaring to be indigenous (RP = 0.37, 95%CI 0.19-0.73) were also associated with not practicing physical activities in the leisure time. CONCLUSIONS The prevalence of leisure-time physical inactivity in Brazilian adolescents is high. It presents regional variations and is associated with age and low socioeconomic status. Special attention should be given to girls and to those who do not engage in any physical activity during the leisure time, so that they can adopt a more active lifestyle.

https://doi.org/10.1590/s01518-8787.2016050006683 7440 downloads

ERICA: leisure-time physical inactivity in Brazilian adolescents
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Revista de Saúde Pública

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2016, Volume 50 Suppl. 1 elocation 4s

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/s01518-8787.2016050006683

Percutaneous treatment of complex biliary stone disease using endourological technique and literature review
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Korkes, Fernando Carneiro, Ariê Nasser, Felipe Affonso, Breno Boueri Galastri, Francisco Leonardo Oliveira, Marcos Belotto de Macedo, Antônio Luiz de Vasconcellos

einstein (São Paulo)

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dec 2015, Volume 13 N. 4 Pages 611 - 614

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A maioria das doenças litiásicas das vias biliares necessita de tratamento cirúrgico. No entanto, em casos especiais, que não permitem o acesso tradicional das vias biliares por via endoscópica, a abordagem multidisciplinar com técnica híbrida, que utiliza instrumentais endourológicos, apresenta-se como uma opção no tratamento. Relatamos aqui o caso de um paciente com litíase de via biliar complexa com múltiplas abordagens prévias, sem sucesso no tratamento com métodos convencionais, resolvido com abordagem híbrida com tecnologia endourológica. Realizamos uma extensa busca na literatura de artigos relacionados ao tratamento de litíase biliar complexa com técnica híbrida publicados no PubMed até outubro de 2012. A abordagem multidisciplinar com técnica híbrida, utilizando instrumental endourológico, representa uma opção segura e eficaz no tratamento de pacientes com litíase complexa de via biliar com impossibilidade de tratamento com métodos convencionais.

Most biliary stone diseases need to be treated surgically. However, in special cases that traditional biliary tract endoscopic access is not allowed, a multidisciplinary approach using hybrid technique with urologic instrumental constitute a treatment option. We report a case of a patient with complex intrahepatic stones who previously underwent unsuccessful conventional approaches, and who symptoms resolved after treatment with hybrid technique using an endourologic technology. We conducted an extensive literature review until October 2012 of manuscripts indexed in PubMed on the treatment of complex gallstones with hybrid technique. The multidisciplinary approach with hybrid technique using endourologic instrumental represents a safe and effective treatment option for patients with complex biliary stone who cannot conduct treatment with conventional methods.

https://doi.org/10.1590/S1679-45082015RC2935 1921 downloads

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Overlapping MRI findings in progressive supranuclear palsy ? corticobasal syndrome
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Prezzi, Eduardo Della Valle Vasconcellos, Luiz Felipe Marussi, Victor Hugo

Arquivos de Neuro-Psiquiatria

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jul 2014, Volume 72 N. 7 Pages 569 - 570

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/0004-282X20140065 2465 downloads

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Neuroimaging in Parkinsonism: a study with magnetic resonance and spectroscopy as tools in the differential diagnosis
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Vasconcellos, Luiz Felipe Rocha Novis, Sergio A. Pereira Moreira, Denise Madeira Rosso, Ana Lucia Z. Leite, Ana Claudia C.B.

Arquivos de Neuro-Psiquiatria

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mar 2009, Volume 67 N. 1 Pages 1 - 6

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O diagnóstico diferencial do parkinsonismo baseado em parâmetros clínicos pode ser difícil. Alguns exames complementares podem ser úteis, especialmente a ressonância magnética, um método não invasivo, de menor custo quando comparado a tomografia por emissão de pósitrons, proporcionando uma análise anatômica satisfatória. A ressonância por espectroscopia analisa o metabolismo cerebral, com resultados variáveis na literatura no estudo das síndromes parkinsonianas. Selecionamos 40 indivíduos para realização de ressonância magnética e espectroscopia, sendo 12 com doença de Parkinson, 11 com paralisia supranuclear progressiva, 7 com atrofia de múltiplos sistemas tipo parkinsoniana e 10 indivíduos sem manifestações neurológicas ou psiquiátricas (grupo controle). As escalas clínicas analisadas foram a de Hoenh e Yahr, unified Parkinson's disease rating scale e o mini-exame do estado mental. Os resultados encontrados revelaram que pacientes com doença de Parkinson e controle apresentavam em geral o mesmo aspecto por imagem enquanto os grupos paralisia supranuclear progressiva e atrofia de múltiplos sistemas com anormalidades, havendo significância estatística em algumas variáveis. A ressonância magnética e a espectroscopia podem ser úteis no diagnóstico diferencial do parkinsonismo.

The differential diagnosis of Parkinsonism based on clinical features, sometimes may be difficult. Diagnostic tests in these cases might be useful, especially magnetic resonance imaging, a noninvasive exam, not as expensive as positron emission tomography, and provides a good basis for anatomical analysis. The magnetic resonance spectroscopy analyzes cerebral metabolism, yielding inconsistent results in parkinsonian disorders. We selected 40 individuals for magnetic resonance imaging and spectroscopy analysis, 12 with Parkinson's disease, 11 with progressive supranuclear palsy, 7 with multiple system atrophy (parkinsonian type), and 10 individuals without any psychiatric or neurological disorders (controls). Clinical scales included Hoenh and Yahr, unified Parkinson's disease rating scale and mini mental status examination. The results showed that patients with Parkinson's disease and controls presented the same aspects on neuroimaging, with few or absence of abnormalities, and supranuclear progressive palsy and multiple system atrophy showed abnormalities, some of which statistically significant. Thus, magnetic resonance imaging and spectroscopy could be useful as a tool in differential diagnosis of Parkinsonism.

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12.

Interaction between estrogen receptor and retinol-binding protein-4 polymorphisms as a tool for the selection of prolific pigs
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Gonçalves, Iara Denise Vasconcellos Gonçalves, Paulo Bayard Dias Silva, Janandra Cortese da Portela Jr, Valério Valdetar Borges, Luiz Felipe Kruel Oliveira, João Francisco Coelho Lovatto, Paulo Alberto

Genetics and Molecular Biology

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2008, Volume 31 N. 2 Pages 481 - 486

Abstract: En | Text: En | PDF: En

The aim of the present study was to investigate the association of the estrogen receptor (ER-PvuII) and retinol-binding protein 4 (RBP4-MspI) gene polymorphisms and their interactions with prolificacy in a commercial synthetic pig line reared in Brazil. A total of 10,374 piglet records from 218 sows and 817 litters were used for litter size analysis. Only females with three or four farrowings were included in the analysis. The mean litter size ranged from 5.0 to 19.5 piglets. DNA was extracted from leukocytes by a standard method, and ER-PvuII and RBP4-MspI polymorphisms were characterized by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. The association between alleles or genotypes and reproductive performance was analyzed using a general linear model including the interaction between the ER-PvuII and RBP4-MspI genotypes. For the ER-PvuII gene, the allele frequencies of allele A and allele B were 0.56 and 0.44, respectively. For the RBP4-MspI gene, the frequencies of alleles A1 and A2 were 0.29 and 0.71, respectively. The total number of piglets born (TNB), born alive (NBA), or number of mummies and stillborn piglets (NMUM and NSB) per litter did not differ between the various ER-PvuII and RBP4-MspI genotypes. However, when the ER-PvuII and RBP4-MspI genotypes were considered together in each sow, TNB and NBA were 1.4 (p = 0.0026) and 0.9 (p = 0.019) higher in AA/A1 and AB/A1 animals, respectively, than in AA/A2 and BB/A1 animals. Likewise, TNB and NBA were 0.9 (p = 0.0258) and 0.8 (p = 0.0168) higher in BB/A2 and AB/A2 sows, respectively, than in AA/A2 and BB/A1 animals, but no difference was observed compared to AA/A1 and AB/A1 animals. The results showed larger litter sizes (TNB and NBA) for sows carrying the ER-PvuII allele A and the RBP4-MspI genotype A1, and for animals carrying the ER-PvuII allele B and the RBP4-MspI genotype A2. In conclusion, the interaction between genotypes ER-PvuII and RBP4-MspI is more efficient in the selection of prolific sows than each one of these molecular markers alone.

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13.

Síndrome psicótica evoluindo com demência como manifestação clinica de deleção do DNA mitocondrial
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Vasconcellos, Luiz Felipe Rocha Leite, Ana Claudia Celestino Cavalcanti, José Luis Sá Moreira, Denise Madeira Feijó, Denise Souza, Carolina Fischinger Moura de

Arquivos de Neuro-Psiquiatria

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mar 2007, Volume 65 N. 1 Pages 114 - 117

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

As manifestações das doenças mitocondriais são variadas, acometendo, mais freqüentemente, órgãos com alto metabolismo aeróbico em que são mais abundantes, como, por exemplo, o sistema nervoso. O início dos sintomas em geral é observado na infância havendo relatos de início na idade adulta. Apresentamos caso atípico de doença mitocondrial associada à deleção do DNA mitocondrial em um homem de 39 anos com sintomas psiquiátricos configuraram quadro clínico inicial e somente 12 anos após o início dos sintomas surgiram alterações neurológicas. O diagnóstico da doença mitocondrial foi confirmado por biópsia de músculo sendo documentada deleção do DNA mitocondrial.

The manifestations of mitochondrial disease are variable, affecting more frequently the organs with high aerobic metabolism in which they are more abundant, for example the nervous system. The beginning of symptoms in general is observed at chilhood, but some patients presented on adult age. We present an atypical case associated with mitochondrial DNA deletion. A 39-years-old man with psychiatric symptoms that configured initial clinical picture and only after 12 years of the beginning of symptoms neurological alterations became noticeable. The diagnosis of mitochondrial illness was confirmed by muscle biopsy being documented mitochondrial DNA deletion.

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14.

Magnetic resonance spectroscopy in the differential diagnosis of parkinsonism
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Vasconcellos, Luiz Felipe Rocha

Arquivos de Neuro-Psiquiatria

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jun 2005, Volume 63 N. 2a Pages 370 - 370

Abstract: En | Text: En | PDF: En

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15.

The influence of different screw tightening forces on the vertical misfit of implant-supported frameworks
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Vasconcellos, Diego Klee de Bottino, Marco Antonio Nishioka, Renato Sussumu Valandro, Luiz Felipe Costa, Elza Maria Valadares da

Journal of Applied Oral Science

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jun 2005, Volume 13 N. 2 Pages 120 - 125

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O presente estudo avaliou o efeito da força de aperto de parafusos de retenção na desadaptação marginal de próteses sobre implantes. A investigação foi conduzida baseada em resultados fornecidos por nove estruturas metálicas implanto-suportadas de seis elementos (02 retentores e 04 pônticos), retidas por parafusos. A mensuração da desadaptação marginal foi realizada com auxílio de microscópio óptico, nos seguintes momentos: M1: aperto com chave manual até a primeira resistência do parafuso; M2: aperto utilizando torquímetro mecânico com 10Ncm e M3: aperto utilizando torquímetro mecânico com 20Ncm. As médias de desadaptação foram submetidas à análise estatística (ANOVA e Tukey). O emprego de torquímetros mecânicos, independente do valor de torque, determinou redução significativa na abertura marginal (p<0,05). A desadaptação média na interface conexão/prótese em M1 foi de 41,56µm (DP±12,45µm). O emprego do torquímetro de 10Ncm (M2), reduziu 52% desta fenda marginal, para uma média de desadaptação de 19,71µm (DP±2,97µm); enquanto o torquímetro de 20Ncm (M3) reduziu 69% da desadaptação marginal, para uma média de 12,82µm (DP±4,0µm) os de retenção de próteses implanto-suportadas tem importante efeito na mensuração da desadaptação marginal, uma vez que pode modificar consideravelmente as aberturas na interface conexão/prótese.

OBJECTIVES: The present in vitro study was designed to compare the differences in the vertical misfit of implant-supported frameworks using three different forces for tightening the bridge locking screws: fastening by hand until first resistance, and using torque drivers with 10 and 20Ncm. METHODS: The investigation was conducted based on the results given by 9 six-unit nickel-chromium (2 abutments/ 4 pontics) screw-retained implant-supported frameworks. The structures were exposed to simulated porcelain firings. The marginal misfit measurements were made using a traveling measuring microscope at selected screw tightening forces: fastening by hand until first resistance, and using torque drivers with 10 and 20Ncm. The results were submitted to one-way ANOVA with repeated measures on one factor, and post hoc pairwise comparisons using Tukey test (5%). RESULTS: The mean marginal misfit of the frameworks, fastening the screws by hand until first resistance, was 41.56µm (SD±12.45µm). The use of torque driver devices caused a significant reduction in marginal opening (p<0.05). With the lowest torque available (10Ncm), the mean marginal discrepancy at the abutment-framework interface was reduced an average of 52% to a mean marginal opening of 19.71µm (SD±2.97µm). After the use of the 20Ncm torque driver, the mean marginal discrepancy of the frameworks was reduced an average of 69% to a mean marginal opening of 12.82µm (SD±4.0µm). Comparing the use of torque drivers with 10 and 20 Ncm torque, the means are not significantly different from one another. CONCLUSION: The seating force has an important effect on the vertical misfit measurements, once it may considerably narrow the vertical misfit gaps at the abutment-framework interface, thus leading to a misjudgment of the real marginal situation.

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