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Abstract We hypothesized that the hCG modulates the expression of IFNT-pathway and ISGs in bovine endometrium during early pregnancy. The aim of the current study is to evaluate the effect of hCG on IFNT-pathway signals and ISGs expression in endometrial cells. For this, 29 non-lactating cross-bread cows were used in the study and submitted to a 9-day fixed-time artificial insemination (FTAI) protocol. The day of the AI was considered Day 0 (D0), and five days (D5) after the FTAI, the cows were allocated into two groups: Control and hCG group, when a hCG group received a single dose of 2.500UI of hCG. On day 18 after FTAI (D18) cows were slaughtered and endometrial tissue samples were collected. There was no difference between the embryo recovery rate of the cows in C compared to the hCG. The hCG group increased the accessory corpus luteum formation rate. The hCG resulted in greater serum progesterone concentration in the hCG group compared to the C on Day 14. Only the expression of IFNAR2 and STAT1 were upregulated on pregnant cows of the hCG group compared to the C group. The pathway genes (JAK1, STAT2, and IRF9) were not regulated. The mRNA abundance of ISG15, MX1, MX2, and OAS1 was upregulated in pregnant cows for hCG group, compared to C group. The results show that the administration of hCG, 5 days after AI, in addition to increasing the serum progesterone, modulates the expression of IFNT-pathway and ISGs on bovine endometrium on Day 18 of pregnancy. IFNTpathway IFNT pregnancy cells this 2 nonlactating non lactating crossbread cross bread 9day 9 fixedtime fixed time (FTAI protocol D0, D0 D , (D0) D5 (D5 groups 2500UI UI 500UI 1 D18 (D18 collected 14 IFNAR STAT JAK1, JAK1 JAK (JAK1 STAT2 IRF9 IRF regulated ISG15 ISG MX1 MX MX2 OAS (D0 (D D1 (D1 (JAK ISG1

https://doi.org/10.1590/1984-3143-ar2023-0130

Relationship between energy balance and key blood metabolites in primiparous dairy cows at different calving conception interval
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Stefanello, Simone

; Amaral, Carolina dos Santos

; Cantarelli, Camila

; Kozloski, Gilberto Vilmar

; Cajarville, Cecilia

; Capello, Jose Luis Repetto

; Mendoza, Alejandro

; Portela, Valério Marques

; Antoniazzi, Alfredo Quites

Ciência Rural

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2024, Volume 54 N. 9 elocation e20230385

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: O objetivo deste estudo foi avaliar a relação entre balanço energético e concentração sanguínea de alguns metabólitos relevantes durante o início da lactação em vacas leiteiras primíparas com diferentes desempenhos reprodutivos. Vinte vacas leiteiras holandesas primíparas foram agrupadas de acordo com o intervalo parto-concepção em precoce (<100 dias), intermediário (100 - 150 dias) e tardio (> 150 dias); e foram avaliados no dia -7 pré-parto, e nos dias 28, 56 e 90 dias pós-parto. Todos os grupos apresentaram balanço energético positivo, concentrações séricas de HDL, N-uréia e progesterona sem diferença nos dias 28 e 56 de lactação. Aos 90 dias de lactação todas vacas apresentaram o balanço energético negativo, porém o grupo de vacas precoce foi menos intenso (P < 0.05) (-1.09 versus -2.15 e -1.86 Mcal/dia), menor concentração sérica de N-uréia (3.28 versus 4.22 e 4.88 mg/dL) e colesterol-HDL (0.84 versus 1.59 e 1.46 mmol/L) e maior concentração sérica de progesterona (8.13 versus 4.54 e 1.83 ng/mL), que vacas dos grupos intermediário e tardio, respectivamente. Em conclusão, diferente do observado usualmente em vacas multíparas, o balanço energético durante as primeiras semanas de lactação não foi um fator determinante do intervalo parto concepção das vacas primíparas do presente estudo. De fato, a condição nutricional e as concentrações séricas de N-ureia e progesterona após 56 dias de lactação sugere ter impacto no atraso da concepção destas vacas. RESUMO reprodutivos partoconcepção <100 100 (<10 dias, , (10 15 > ( 7 préparto, préparto pré parto, pré-parto 5 9 pósparto. pósparto pós parto. pós-parto positivo HDL Nuréia N uréia 2 negativo P 0.05 005 0 05 1.09 109 1 09 (-1.0 2.15 215 -2.1 1.86 186 86 -1.8 Mcal/dia, Mcaldia Mcal/dia Mcal Mcal/dia) 3.28 328 3 (3.2 422 4 22 4.2 488 88 4.8 mg/dL mgdL mg dL colesterolHDL colesterol 0.84 084 84 (0.8 159 59 1.5 146 46 1.4 mmol/L mmolL mmol L 8.13 813 8 13 (8.1 454 54 4.5 183 83 1.8 ng/mL, ngmL ng/mL ng mL ng/mL) respectivamente conclusão multíparas fato Nureia ureia <10 10 (<1 (1 0.0 00 1.0 (-1. 2.1 21 -2. 18 -1. 3.2 32 (3. 42 4. 48 0.8 08 (0. 1. 14 8.1 81 (8. 45 <1 (< 0. (-1 2. -2 -1 3. (3 (0 8. (8 (-

ABSTRACT: This study identified the relationship between energy balance and some blood metabolites in primiparous dairy cows with different calving conception interval. Twenty primiparous Holstein-Friesian dairy cows were grouped according to the interval (days) from calving to conception into early-conception (early-c; <100 days), mid-conception group (mid-c; 100 - 150 days) or late-conception (late-c; >150 days) group; and evaluated on day -7 prior to parturition, and days 28, 56 and 90 postpartum. All groups presented positive energy balance, serum concentrations of HDL, urea-N and progesterone with no difference on days 28 and 56 of lactation. On day 90 of lactation all the cows presented negative energy balance; however, the early-c group presented a less intense (P < 0.05) net energy balance (-1.09 versus -2.15 and -1.86 Mcal/day), lower concentrations of serum urea-N (3.28 versus 4.22 and 4.88 mg/dL) and HDL cholesterol (0.84 versus 1.59 and 1.46 mmol/L) and greater serum concentration of progesterone (8.13 versus 4.54 and 1.83 ng/mL) than cows of mid-c and late-c groups, respectively. In conclusion, different from those usually observed for multiparous dairy cows, the energy balance during the first weeks of lactation was not a determining factor affecting the calving conception interval of primiparous dairy cows in the present study. Instead, the nutritional status and the serum concentration of urea-N and progesterone at a later stage, after 56 days of lactation, suggest having a role in delaying these cows’ pregnant status. ABSTRACT HolsteinFriesian Holstein Friesian (days earlyconception early earlyc c (early-c <10 days, , midconception mid midc (mid-c 10 15 lateconception late latec (late-c >15 7 parturition 5 9 postpartum ureaN urea N 2 however P 0.05 005 0 05 1.09 109 1 09 (-1.0 2.15 215 -2.1 1.86 186 86 -1.8 Mcal/day, Mcalday Mcal/day Mcal Mcal/day) 3.28 328 3 (3.2 422 4 22 4.2 488 88 4.8 mg/dL mgdL mg dL 0.84 084 84 (0.8 159 59 1.5 146 46 1.4 mmol/L mmolL mmol L 8.13 813 8 13 (8.1 454 54 4.5 183 83 1.8 ng/mL ngmL ng mL respectively conclusion Instead stage <1 >1 0.0 00 1.0 (-1. 2.1 21 -2. 18 -1. 3.2 32 (3. 42 4. 48 0.8 08 (0. 1. 14 8.1 81 (8. 45 > 0. (-1 2. -2 -1 3. (3 (0 8. (8 (- (

https://doi.org/10.1590/0103-8478cr20230385

Nicotinamide and phytohormones as biostimulants in common bean
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Bernardo, Vitória Fátima

; Lima, Sebastião Ferreira de

; Santos, Gleciane Aparecida Valério dos

; Alves, Vitória Carolina Dantas

; Vendruscolo, Eduardo Pradi

; Nunes, Rita de Cássia Barros

Revista Ceres

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2024, Volume 71 elocation e71035

Abstract: En | Text: En | PDF: En

ABSTRACT The cultivation of beans (Phaseolus vulgaris L.) is of great importance to the national economy since they are grown in almost all regions of Brazil and the use of biostimulants based on phytohormones and plant vitamins can improve the yield of the crop. This work aimed to evaluate the effects of the application of the vitamin nicotinamide and phytohormones as biostimulants on bean plants. The experimental design was carried out in randomized blocks in a 2 x 5 factorial scheme with 4 replicates. The treatments consisted of the application of five doses of nicotinamide (0, 200, 400, 600 and 800 mg L-1) in the presence or absence of phytohormones containing auxin, gibberellin and cytokinin. The growth characteristics, production components and productivity of the bean grains were evaluated. The use of phytohormones and nicotinamide alone or together favored the growth, production components and grain productivity of the bean plant. The range of 366 to 469 mL L-1 nicotinamide achieved the highest values for the growth variables, production components and grain productivity of the bean plant, with 414 mL L-1 being the most suitable to achieve higher grain productivity. Phaseolus L. L crop plants replicates 0, 0 (0 200 400 60 80 L1 1 auxin cytokinin characteristics evaluated 36 46 L- variables 41 ( 20 40 6 8 3

https://doi.org/10.1590/0034-737x2024710035

Operação Suposição de Sujeito no contexto de Terapia Semi-Intensiva Neonatal: relato de caso SemiIntensiva Semi Intensiva Neonatal
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Souza, Beatriz Torres Chebel de

; Barros, Carolina Valério

Revista Latinoamericana de Psicopatologia Fundamental

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oct 2022, Volume 25 N. 4 Pages 668 - 689

L’opération d’“assomption sujet” comprend l’un des quatre axes qui sous-tendent la recherche utilisant les indicateurs cliniques de risque pour le développement de l’enfant (IRDI) et consiste en une anticipation effectuée par l’agent maternel pour le compte d’un sujet qui n’est pas encore constitué. Cet article présente un rapport de cas qui visait à étudier comment cette opération se déroule dans une unité de soins semi-intensifs néonatals. Pour ce faire, un entretien semi-directif a été mené, suivi de l’application du protocole IRDI et de l’instrument Denver II. Les résultats ont montré que l’hypothèse du sujet peut se produire, mais, dans ce cas clinique, elle était insoutenable et non opérationnelle, puisque la relation mère-enfant était probablement influencée par la limitation physique du bébé, son hospitalisation prolongée et les aspects émotionnels de la mère. Lopération L dassomption d assomption lun l soustendent sous tendent lenfant enfant (IRDI lagent agent dun nest n est constitué semiintensifs semi intensifs néonatals faire semidirectif directif mené lapplication application linstrument instrument II lhypothèse hypothèse produire mais clinique opérationnelle mèreenfant mère bébé

La operación de la suposición del sujeto es uno de los cuatro ejes que sostienen el estudio con indicadores clínicos de riesgo para el desarrollo infantil (IRDI) y consiste en una anticipación realizada por el agente de la función materna de un sujeto en el bebé, que todavía no se encuentra constituido. Este trabajo propone presentar el reporte de caso con el objetivo de investigar cómo la operación de suposición de sujeto ocurre en el contexto de hospitalización en una Unidad de Cuidados Semiintensivos Neonatal. Para eso, se realizaron una entrevista semiestruturada, la aplicación del protocolo IRDI y el instrumento Denver II. Se ha notado que la suposición de sujeto puede ocurrir, pero todavía en este caso clínico se muestran dificultades para que se sustente y opere, una vez que la relación madre-bebé posiblemente fue influenciada por limitaciones físicas del bebé, su hospitalización prolongada y aspectos emocionales de la madre. (IRDI bebé constituido Neonatal eso semiestruturada II ocurrir opere madrebebé madre

A operação de suposição de sujeito compreende um dos quatro eixos que fundamentam a pesquisa IRDI e consiste em uma antecipação realizada pelo agente da função materna de um sujeito no bebê, que não se encontra ainda constituído. Este trabalho se propõe a apresentar um relato de caso que teve como objetivo investigar como a operação de suposição de sujeito ocorre em um contexto de internação em uma Unidade de Terapia Semi-Intensiva Neonatal. Para isso, foram realizadas uma entrevista semiestruturada, a aplicação do protocolo IRDI (Indicadores Clínicos de Risco para o Desenvolvimento Infantil) e do instrumento Denver II. Observou-se que a suposição de sujeito pode ocorrer, mas neste caso clínico apresenta dificuldades para se sustentar e operar, já que a relação mãe-bebê possivelmente foi influenciada pela limitação física do bebê, sua internação prolongada e aspectos emocionais da mãe. bebê constituído SemiIntensiva Semi Intensiva Neonatal isso semiestruturada Indicadores Infantil II Observouse Observou ocorrer operar mãebebê mãe

Subject assumption operation is one of the four axes that underlie research using Clinical Indicators of Risk for Child Development (IRDI) and consists of an anticipation performed by the maternal agent on the behalf of a not yet constituted subject - the baby. This paper presents a case report that aimed to investigate how the subject assumption operation occurs in a neonatal semi intensive care unit. To do so, a semi-structured interview was conducted followed by application of the IRDI protocol and the Denver II instrument. Results showed that the subject assumption can occur, but, in this clinical case, it was unsustainable and non-operational, since the mother-child relation was possibly influenced by the physical limitation of the baby, their prolonged hospitalization, and emotional aspects of the mother. (IRDI baby unit so semistructured structured instrument occur but nonoperational, nonoperational non operational, operational non-operational motherchild mother child hospitalization

https://doi.org/10.1590/1415-4714.2022v25n4p668.9

The Pterygospinous Foramen (Civinini) and the Pterygoalar (Crotaphitico-Buccinatorius). Laboratory Findings
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Oliveira, Kennedy Martinez de

; de-Almeida, Valério Landim

; López, Carlos Alberto Carranza

; Brandão, Guilherme Tatagiba

; Trancoso, Marcos Guilherme Bedim

; Oliveira, Maísa de Fátima Satiro

; Morais, Isabela Coimbra Ladeira

; Soares, Daniele Cristina Barbosa

; Costa, Luana Carolina Maletta

International Journal of Morphology

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feb 2021, Volume 39 N. 1 Pages 198 - 204

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

SUMMARY: The Pterygospinous foramen and pterygoalar foramen (crotaphitico-buccinatorius) are variant and atavic formations of the skull base and arise respectively from complete or incomplete idiopathic ossifications of the pterygospinous and pterygoalar ligaments. By proximity with areas of relevance for diagnosis and surgery, such as access pathways to the parapharyngeal and retropharyngeal spaces, it is necessary to be aware of these conditions due to the difficulties generated in surgical maneuvers and the promotion of compressive syndromes of mandibular nerve branches. This study was conducted on 45 samples of dry skulls and disarticulated sphenoid bones belonging to the collection of the Federal University of Juiz de Fora, Governador Valadares campus, Minas Gerais, Brazil. Our results indicated a total incidence of complete and incomplete pterygospinous and pterygoalar foramen (crotaphitico- buccinatorius) in 15, 5 % (7 skulls), with a higher incidence for the incomplete form of pterygospinous foramen (Civinini foramen) in 4 skulls (8.8 %), with 3 presenting unilaterally and 3 presenting bilaterally. The pterygoalar foramen (crotaphitico-buccinatorius or Hyrtl) was noted bilaterally in 1 of the skulls (2.2 %). The pterygospinous foramen and pterygoalar foramen are important findings, sometimes incidental, of an area of great anatomical expressiveness and pathological occurrences, besides the indispensable and unclear studies of phylogenetic order.

RESUMEN: El foramen pterigoespinoso y el foramen pterigoalar (crotafítico-buccinatorius) son formaciones variantes y atávicas de la base del cráneo y surgen respectivamente de osificaciones idiopáticas completas o incompletas, de los ligamentos pterigoespinoso y pterigoalar. Debido a la proximidad con áreas de relevancia para el diagnóstico y la cirugía, como las vías de acceso a los espacios parafaríngeo y retrofaríngeo, es necesario conocer estas condiciones por las dificultades que se generan en las maniobras quirúrgicas. Este estudio se realizó en 45 muestras de cráneos secos y huesos esfenoides desarticulados pertenecientes a la colección de la Universidad Federal de Juiz de Fora, campus Governador Valadares, Minas Gerais, Brasil. Nuestros resultados indicaron una incidencia total de foramen pterigoespinoso y pterigoalar completo e incompleto (crotafítico-buccinatorius) en el 15,5 % (7 cráneos), con una mayor incidencia de la forma incompleta de foramen pterigoespinoso (agujero de Civinini) en 4 cráneos (8,8 %), con 3 de presentación unilateral y 3 de presentación bilateral. El foramen pterigoalar (crotaphitico-buccinatorius o Hyrtl) se observó bilateralmente en 1 de los cráneos (2,2 %). El foramen pterigoespinoso y pterigoalar son hallazgos importantes, a veces incidentales, de un área de gran expresividad anatómica y ocurrencias patológicas, además de los estudios indispensables y poco claros de orden filogenético.

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Evaluation of interferon-stimulated gene 15 (ISG15) expression in blood neutrophils in beef cattle poisoned by Senecio spp.
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Stefanello, Simone

; Amaral, Carolina S.

; Zappe, Igor G.

; Mujica, Lady K.S.

; Emanuelli, Mauren P.

; Portela, Valério M.

; Ramos, Adriano T.

; Antoniazzi, Alfredo Q.

Pesquisa Veterinária Brasileira

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2021, Volume 41 elocation e06880

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: O objetivo deste estudo foi avaliar a lesão hepática e a expressão sanguínea do gene estimulado por interferon 15 (ISG15) durante a sinalização embrionária, no reconhecimento materno da gestação, em bovinos de corte apresentando ingestão natural de Senecio spp. Fatores epidemiológicos, como a presença da planta, associados à atividade da gama glutamil transferase (GGT) podem ser utilizados como diagnóstico da intoxicação por Senecio spp. O reconhecimento materno da gestação ocorre quando o embrião secreta interferon tau (IFNT) para sinalizar sua presença à mãe. Em nosso estudo, a lesão hepática foi determinada pela concentração sérica de GGT, pelos exames citológicos e histopatológicos. O estado reprodutivo foi avaliado pela concentração de progesterona, diâmetro de corpo lúteo (CL) e expressão de mRNA ISG15 no Dia 19 após a inseminação artificial em tempo fixo (IATF). As vacas foram separadas em dois grupos com base na concentração de GGT sanguíneo: Grupo 1 (GGT<30U/L) e Grupo 2 (GGT>31U/L). Não foi observada nenhuma diferença no escore de condição corporal entre os grupos. Na citologia e nos exames histopatológicos todas as vacas apresentaram lesão hepática. As vacas do Grupo 1 apresentaram maior taxa de prenhez, maior diâmetro do CL e maior concentração de progesterona. Diferente do esperado, a expressão do mRNA ISG15 não foi diferente entre os Grupos 1 e 2, mesmo apresentando diferença na taxa de prenhez. Esses achados sugerem perda embrionária após o Ddia 19. Isso demonstra que a mortalidade embrionária tardia pode estar associada à insuficiência hepática. Dessa forma, conclui-se que a lesão hepática e/ou concentração de GGT não altera a expressão de ISG15 nos neutrófilos sanguíneos, porém vacas com menor concentração de GGT (<30U/L) apresentaram maiores taxas de prenhez. Assim, a concentração de GGT nos permite avaliar a saúde hepática e prever uma gestação bem-sucedida em bovinos de corte.

ABSTRACT: This study aimed to assess liver damage and interferon-stimulated gene 15 (ISG15) blood expression as a consequence of embryonic signaling on maternal recognition of pregnancy in beef cattle presenting natural ingestion of Senecio spp. Epidemiological aspects, as the presence of the plant, associated to gamma glutamyl transferase (GGT) activity can be used as Senecio spp. poisoning diagnosis. Maternal recognition of pregnancy period occurs when the embryo secretes interferon tau (IFNT) to signal its presence to the mother and eventually extend corpus luteum (CL) lifespan. In our study, liver damage was determined by concentration serum GGT, cytological and histopathological examinations. Reproductive status was evaluated by concentration of progesterone, CL diameter and ISG15 mRNA expression on Day 19 following fixed-time artificial insemination (FTAI). Cows were categorized into two groups based on concentration of GGT: Group 1 (GGT<30U/L) and 2 (GGT>31U/L). No difference on body condition scores was observed. All the cows presented liver damage based on cytology and histopathological exams. Cows from the Group 1 had higher pregnancy rate, presenting larger CL diameter and greater concentration of progesterone. Interestingly, ISG15 mRNA expression had no difference between Groups 1 and 2, even presenting difference in pregnancy status. These findings suggest embryonic loss beyond Day 19. It suggests late embryonic mortality may be associated to liver insufficiency. In conclusion, liver injury and/or concentration of GGT does not alter ISG15 expression on blood neutrophils, however cows presenting lower concentration of GGT (<30U/L) had increased pregnancy status. Therefore, the concentration of GGT allow us to screen liver status and foresee a successful pregnancy in beef cattle.

https://doi.org/10.1590/1678-5150-pvb-6880 114 downloads

Possible impact of neutrophils on immune responses during early pregnancy in ruminants
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Fiorenza, Mariani Farias

; Amaral, Carolina dos Santos

; Anunciação, Adriana Raquel de Almeida da

; Portela, Valério Valdetar Marques

; Marey, Mohammed Ali

; Miyamoto, Akio

; Antoniazzi, Alfredo Quites

Animal Reproduction

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2021, Volume 18 N. 3 elocation e20210048

Abstract: En | Text: En | PDF: En

Abstract The interaction between early embryo and maternal immune system for the establishment of pregnancy is the focus of several studies; however, it remains unclear. The maternal immune response needs to keep a balance between avoiding any damage to the conceptus and maintaining its function in combating microbes as well. When conceptus-maternal crosstalk cannot achieve this balance, pregnancy losses might occur. Intercommunication between mother and conceptus is fundamental during early pregnancy to dictate the outcome of pregnancy. In ruminants, the embryo reacts with the maternal system mainly via interferon tau (IFNT) release. IFNT can act locally on the embryo and endometrial cells and systemically in several tissues and cells to regulate their response via the expression of interferon-stimulated genes (ISGs). Also, IFNT can induce the expression of inflammatory-related genes in immune cells. Day 7 embryo induces a shift in the maternal immune response towards anti-inflammatory (Th2) immune responses. During maternal recognition of pregnancy, peripheral mononuclear cells (PBMCs) and polymorphonuclear cells (PMNs) express markers that configure an anti-inflammatory response. However, PMNs response is more sensitive to the effects of IFNT. PMNs are more likely to express interferon-stimulated genes (ISGs), transforming growth factor-beta (TGFB), interleukin 10 (IL10), and arginase-1 (ARG1), configuring one of the most rapid immune responses to early pregnancy. This review focus on the local and peripheral immune responses during early pregnancy in ruminants, mainly the PMNs function in the immune system.

https://doi.org/10.1590/1984-3143-ar2021-0048 61 downloads

The Program for Biodiversity Research in Brazil: The role of regional networks for biodiversity knowledge, dissemination, and conservation
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ROSA, CLARISSA

; BACCARO, FABRICIO

; CRONEMBERGER, CECILIA

; HIPÓLITO, JULIANA

; BARROS, CLAUDIA FRANCA

; RODRIGUES, DOMINGOS DE JESUS

; NECKEL-OLIVEIRA, SELVINO

; OVERBECK, GERHARD E.

; DRECHSLER-SANTOS, ELISANDRO RICARDO

; ANJOS, MARCELO RODRIGUES DOS

; FERREGUETTI, ÁTILLA C.

; AKAMA, ALBERTO

; MARTINS, MARLÚCIA BONIFÁCIO

; TOMAS, WALFRIDO MORAES

; SANTOS, SANDRA APARECIDA

; FERREIRA, VANDA LÚCIA

; CUNHA, CATIA NUNES DA

; PENHA, JERRY

; PINHO, JOÃO BATISTA DE

; SALIS, SUZANA MARIA

; DORIA, CAROLINA RODRIGUES DA COSTA

; PILLAR, VALÉRIO D.

; PODGAISKI, LUCIANA R.

; MENIN, MARCELO

; BÍGIO, NARCÍSIO COSTA

; ARAGÓN, SUSAN

; MANZATTO, ANGELO GILBERTO

; VÉLEZ-MARTIN, EDUARDO

; SILVA, ANA CAROLINA BORGES LINS E

; IZZO, THIAGO JUNQUEIRA

; MORTATI, AMANDA FREDERICO

; GIACOMIN, LEANDRO LACERDA

; ALMEIDA, THAÍS ELIAS

; ANDRÉ, THIAGO

; SILVEIRA, MARIA AUREA PINHEIRO DE ALMEIDA

; SILVEIRA, ANTÔNIO LAFFAYETE PIRES DA

; MESSIAS, MARILUCE REZENDE

; MARQUES, MARCIA C.M.

; PADIAL, ANDRE ANDRIAN

; MARQUES, RENATO

; BITAR, YOUSZEF O.C.

; SILVEIRA, MARCOS

; MORATO, ELDER FERREIRA

; PAGOTTO, RUBIANI DE CÁSSIA

; STRUSSMANN, CHRISTINE

; MACHADO, RICARDO BOMFIM

; AGUIAR, LUDMILLA MOURA DE SOUZA

; FERNANDES, GERALDO WILSON

; OKI, YUMI

; NOVAIS, SAMUEL

; FERREIRA, GUILHERME BRAGA

; BARBOSA, FLÁVIA RODRIGUES

; OCHOA, ANA C.

; MANGIONE, ANTONIO M.

; GATICA, AILIN

; CARRIZO, MARÍA CELINA

; RETTA, LUCÍA MARTINEZ

; JOFRÉ, LAURA E.

; CASTILLO, LUCIANA L.

; NEME, ANDREA M.

; RUEDA, CARLA

; TOLEDO, JOSÉ JULIO DE

; GRELLE, CARLOS EDUARDO VIVEIROS

; VALE, MARIANA M.

; VIEIRA, MARCUS VINICIUS

; CERQUEIRA, RUI

; HIGASHIKAWA, EMÍLIO MANABU

; MENDONÇA, FERNANDO PEREIRA DE

; GUERREIRO, QUÊZIA LEANDRO DE MOURA

; BANHOS, AUREO

; HERO, JEAN-MARC

; KOBLITZ, RODRIGO

; COLLEVATTI, ROSANE GARCIA

; SILVEIRA, LUÍS FÁBIO

; VASCONCELOS, HERALDO L.

; VIEIRA, CECÍLIA RODRIGUES

; COLLI, GUARINO RINALDI

; CECHIN, SONIA ZANINI

; SANTOS, TIAGO GOMES DOS

; FONTANA, CARLA S.

; JARENKOW, JOÃO A.

; MALABARBA, LUIZ R.

; RUEDA, MARTA P.

; ARAUJO, PUBLIO A.

; PALOMO, LUCAS

; ITURRE, MARTA C.

; BERGALLO, HELENA GODOY

; MAGNUSSON, WILLIAM E.

Anais da Academia Brasileira de Ciências

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2021, Volume 93 N. 2 elocation e20201604

Abstract: En | Text: En | PDF: En

Abstract The Program for Biodiversity Research (PPBio) is an innovative program designed to integrate all biodiversity research stakeholders. Operating since 2004, it has installed long-term ecological research sites throughout Brazil and its logic has been applied in some other southern-hemisphere countries. The program supports all aspects of research necessary to understand biodiversity and the processes that affect it. There are presently 161 sampling sites (see some of them at Supplementary Appendix), most of which use a standardized methodology that allows comparisons across biomes and through time. To date, there are about 1200 publications associated with PPBio that cover topics ranging from natural history to genetics and species distributions. Most of the field data and metadata are available through PPBio web sites or DataONE. Metadata is available for researchers that intend to explore the different faces of Brazilian biodiversity spatio-temporal variation, as well as for managers intending to improve conservation strategies. The Program also fostered, directly and indirectly, local technical capacity building, and supported the training of hundreds of undergraduate and graduate students. The main challenge is maintaining the long-term funding necessary to understand biodiversity patterns and processes under pressure from global environmental changes.

https://doi.org/10.1590/0001-3765202120201604 1034 downloads

Reaction of soybean cultivars to Meloidogyne javanica and Meloidogyne incognita
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Mazzetti, Valéria Cecília Ghissi

; Visintin, Gustavo Luiz

; Valério, Igor Pirez

; Camera, Juliane Nicolodi

; Deuner, Carolina Cardoso

; Soares, Pedro Luiz Martins

Revista Ceres

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jun 2019, Volume 66 N. 3 Pages 220 - 225

Abstract: En | Text: En | PDF: En

ABSTRACT Nematodes of the genus Meloidogyne are associated with soybean cultivation, unknown the reaction of cultivars. The objective of this work was to determine the reaction of soybean cultivars to M. javanica and M. incognita. Twenty-seven soybean cultivars were sown in plastic pots, in a completely randomized experimental design with eight replicates. Ten days after emergence of the seedlings, in a separate experiment, M. javanica and M. incognita were inoculated. For M. javanica, cultivars classified as susceptible were BMX Lança IPRO, AMS Tibagi RR, BMX Vanguarda IPRO, NS 6700 IPRO, BMX Ativa RR, FPS Solimões RR, TEC 6702 IPRO, NS 5909 RR, NS 5445 IPRO, 54i52 RSF IPRO, M 6410 IPRO and NS 5959 IPRO and BMX Elite IPRO, NA 6211 RR, BMX Valente RR, FPS Júpter RR, FPS Iguaçú RR, BMX Tornado RR, GMX Cancheiro RR, TMG 7161 IPRO, TMG 7062 IPRO, FPS Solar RR, M 5730 IPRO, DM5958 RSF IPRO, NS 6006 IPRO, SYN 1163 RR and M 5947 IPRO were resistant. Regarding M. incognita, the resistant cultivars were FPS Iguaçú RR, FPS Solar IPRO, SYN 1163 RR and TMG 7062 IPRO. The cutlivars FPS Júpter RR, SYN 1163 RR e TMG 7062 IPRO were resistant to both nematodes.

https://doi.org/10.1590/0034-737x201966030008 799 downloads

10.

Characterization of 'Sabará' Jabuticabas at different maturation stages
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Becker, Fernanda Salamoni

; Vilas Boas, Ana Carolina

; Sales, Adones

; Tavares, Lucas Silveira

; Siqueira, Heloisa Helena de

; Vilas Boas, Eduardo Valério de Barros

Acta Scientiarum. Agronomy

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dec 2015, Volume 37 N. 4 Pages 457 - 462

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O presente trabalho teve como objetivo avaliar as características físico-químicas e de atividade enzimática de jabuticabas 'Sabará' cultivadas em Lavras, Estado de Minas Gerias, Brasil, em diferentes estádios de maturação. Os frutos foram colhidos e separados em cinco diferentes estádios: frutos totalmente verdes; frutos com início de pigmentação; frutos com predominância roxo claro; frutos totalmente roxos e frutos totalmente roxo-escuro. Em seguida, os frutos foram submetidos às análises físico-químicas e a atividade da enzima poligalacturonase. Foi possível observar a degradação da clorofila e a síntese de antocianinas na casca dos frutos, bem como a degradação da parede celular e o conseqüente amaciamento dos mesmos. Na polpa, observou-se um aumento de sólidos solúveis, pH e açúcares, bem como uma diminuição da acidez à medida que o grau de maturação foi aumentando.

ABSTRACT This work aimed to evaluate the physicochemical characteristics and enzymatic activity of "Sabará" jabuticaba fruits, which were cultivated in Lavras, Minas Gerais State, Brazil, at different maturation stages. The fruits were harvested and separated into five different stages: totally green fruit, fruit with incipient pigmentation, fruit with a light purple predominance, totally purple fruit and totally dark purple fruit. These fruits were physicochemically analyzed and evaluated for polygalacturonase enzymatic activity. Chlorophyll degradation and the synthesis of anthocyanin on fruit rinds were observed, as well as the degradation of the cell wall and its consequent softening. In the pulp, increased soluble solids, pH and sugars were observed, while acidity decreased as maturation progressed.

https://doi.org/10.4025/actasciagron.v37i4.19499 1302 downloads

11.

In vitro evaluation of Biosilicate® dissolution on dentin surface: a SEM analysis
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Pinheiro, Michele Carolina

; Lopes, Beatriz Maria Valério

; Cavassim, Rodrigo

; Pinto, Shelon Cristina Souza

; Sampaio, José Eduardo Cezar

Revista de Odontologia da UNESP

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aug 2013, Volume 42 N. 4 Pages 251 - 258

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

INTRODUÇÃO: Biomateriais, tais como vidros bioativos e vidros cerâmicos têm sido propostos para o tratamento da hipersensibilidade dentinária. OBJETIVO: Avaliar por microscopia eletrônica de varredura (SEM), a dissolução de uma nova vitrocerâmica bioativa (Biosilicato®, partículas de 1-20 µm) na superfície de amostras de dentina, com diferentes métodos de aplicação e de meio de diluição diferente, usado para aplicação de Biosilicato®. MATERIAL E MÉtODO: 280 amostras de dentina foram divididas aleatoriamente em quatro grupos: (1) Biosilicato® mais flúor gel aplicado com escova de Robinson, (2) Biosilicato® mais flúor gel aplicado com microbrush, (3) Biosilicato® mais água destilada aplicado com escova de Robinson; (4) Biosilicato® mais água destilada aplicado com microbrush. Após o tratamento, as amostras foram imersas em saliva, em diferentes períodos (0, 30 e 15 minutos, 1, 2, 12 e 24 horas). Duas fotomicrografias foram obtidas a partir de cada amostra e foram analisadas por um examinador calibrado cego de acordo com um "Índice de Dissolução de Partículas", criado para este estudo. RESULTADO: Os dados foram analisados usando o teste de Mann-Whitney, Kruskal-Wallis e Dunn. Não houve diferença estatística entre os graus de dissolução entre os quatro grupos em qualquer período. CONCLUSÃO: Biosilicato® pode ser incorporado em ambas às substâncias, sem diferenças no grau de dissolução das partículas em qualquer dos períodos de avaliação e a aplicação sobre da dentina pode ser realizada com os dois métodos avaliados.

INTRODUCTION: Biomaterials such as bioactive glasses and glass-ceramics have been proposed for the treatment of dentinal hypersensitivity. OBJECTIVE: to evaluate by scanning electron microscopy (SEM), the dissolution of a novel bioactive glass-ceramic (Biosilicate® 1-20 µm particles) on dentin surface samples, with different application methods and different dilution medium used for applying Biosilicate®. MATERIAL AND METHOD: 280 dentin samples were randomly divided into four groups: (1) Biosilicate® plus fluoride gel applied with Robinson brush; (2) Biosilicate® plus fluoride gel applied with microbrush; (3) Biosilicate® plus distilled water applied with Robinson brush; (4) Biosilicate® plus distilled water applied with microbrush. After treatment, the samples were immersed in saliva at different periods (0, 15 and 30 minutes, 1, 2, 12 and 24 hours). Two photomicrographs were obtained from each sample and were further analyzed by a blind calibrated examiner according to a "Particle Dissolution Index" created for this study. RESULT: The data were analyzed using the Mann-Whitney, Kruskal-Wallis and Dunn's tests. There was no statistical difference among the degrees of dissolution between the 4 groups in any period. CONCLUSION: Biosilicate® can be incorporated in both substances without differences in the degree of dissolution of the particles in any of the evaluated periods and the application of dentine can be performed with both methods evaluated.

1530 downloads

12.

pH e umidade dos resíduos finos de beneficiamento de rochas ornamentais
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Neves, Mirna Aparecida

; Nadai, Carolina Peterle de

; Fonseca, Arthur Bazoni da

; Prado, Ana Candida de Almeida

; Giannotti, Juliana Di Giorgio

; Raymundo, Valério

Rem: Revista Escola de Minas

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jun 2013, Volume 66 N. 2 Pages 239 - 244

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Apresenta-se um estudo do comportamento do pH e da taxa de umidade dos resíduos finos de beneficiamento de rochas ornamentais. Amostras foram coletadas durante a serragem de blocos e polimento das chapas e,ainda, após passarem pelo filtro-prensa. Foram coletadas de depósitos de diferentes idades, incluindo um depósito temporário de 3 meses, um depósito de 5 anos e outro de 20 anos. O pH e a taxa de umidade foram medidos de acordo com as NBR 10.004/2004 e 10.006/2004. No que se refere ao pH, os resíduos não se enquadraram na classe dos perigosos, em nenhum dos casos estudados. Esse parâmetro decai com o tempo, mesmo em condições inadequadas de armazenamento. O estudo mostrou que o uso do filtro-prensa diminui o pH e a umidade do resíduo conforme as exigências normativas e que o mesmo resultado pode ser obtido em leitos de secagem construídos corretamente. Problemas de umidade foram observados no depósito antigo, onde os valores aumentam com a profundidade, chegando aos níveis do resíduo recém-gerado mesmo após 20 anos de armazenamento. Esses resíduos estão situados em planície aluvionar e próximos a um canal de drenagem.

The aim of this work was to analyze pH and humidity variations of fine wastes from processing dimension stones. Samples were collected during block cutting; plate polishing; after filter press and at deposits of different ages, including a temporary deposit 3 months old, a deposit of wastes 5 years old and another 20 years old. The pH and humidity were measured according to NBR 10.004/2004 and NBR 10.006/2004. Regarding pH values, wastes are not classified as dangerous in any case. Such parameter decays with time, even at inadequate storing conditions. This research showed that the use of a filter press decreases the pH and humidity of wastes according to regulatory requirements and the same results can be reached using correctly built pond drying. Humidity problems were found in the ancient deposit, where values increased at depth, reaching levels similar to newly generated wastes even after 20 year of storing. These wastes are located at alluvial plain, near a drainage channel.

2175 downloads Cited 2 times in SciELO

13.

Tratamento cirúrgico e conservador da agenesia vaginal: análise de uma série de casos
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Marin, Juliana Straehl

; Lara, Lúcia Alves da Silva

; Silva, Adriana Valério da

; Reis, Rosana Maria dos

; Junqueira, Flávia Raquel

; Rosa-e-Silva, Ana Carolina Japur de Sá

Revista Brasileira de Ginecologia e Obstetrícia

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jun 2012, Volume 34 N. 6 Pages 274 - 277

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVO: Avaliar os resultados do tratamento da agenesia vaginal pela técnica cirúrgica de McIndoe-Bannister modificada e pela técnica de Frank. MÉTODOS: Este estudo retrospectivo foi conduzido com uma amostra de conveniência de 25 mulheres portadoras de agenesia vaginal em seguimento no Ambulatório de Ginecologia Infanto Puberal. Quinze mulheres foram submetidas à cirúrgica modificada de McIndoe-Bannister Grupo Cirúrgico e 10 fora tratadas com a técnica de Frank Grupo Frank. Para a análise comparativa entre essas duas amostras, foram considerados os seguintes parâmentros: vaginometria final, efeitos adversos e satisfação sexual após o tratamento. Esses dados foram obtidos por meio dos registros nos prontuários médicos. A satisfação sexual foi aferida por questão simples: como está sua vida sexual? RESULTADOS: Houve diferença em relação ao comprimento da vagina tanto naquelas submetidas à técnica de Frank (comprimento inicial 2,4±2,0 cm, após o tratamento 6,9±1,1 cm, p<0,0001), quanto naquelas submetidas à técnica cirúrgica (comprimento inicial 0,9±1,4 cm, após o tratamento 8,0±0,8 cm, p<0,0001). A vaginometria foi maior no Grupo Cirúrgico (Grupo Frank=7,0±0,9 cm versus Grupo Cirúrgico=8,0±0,8 cm, p=0,0005). Quarenta por cento do Grupo Cirúrgico tiveram complicações cirúrgicas. Não foram registradas complicações pela técnica de Frank. A satisfação sexual foi referida pela totalidade das pacientes. CONCLUSÃO: Os dados do presente estudo indicam que ambas as técnicas, cirúrgica e conservadora são eficientes para o tratamento da agenesia vaginal, resultando na construção da vagina favorável à realização do coito e com satisfação sexual. Os aspectos favoráveis da técnica de Frank estão relacionados com o baixo custo e baixos índices de complicações.

PURPOSE: This study aimed to evaluate the results of neovaginoplasty by a modified McIndoe-Bannister technique and by the non-surgical Frank technique. METHODS: This retrospective study was conducted on a convenience sample of 25 women with vaginal agenesis undergoing surgical or conservative treatment at an Infant-Pubertal Gynecology Outpatient Clinic. Data were obtained from the medical records. Fifteen women underwent the surgical McIndoe-Bannister modified technique Surgical Group, and 10 women underwent the non-surgical Frank technique Frank Group. The following parameters were considered for comparative analysis between the two samples: vaginometry, surgical and non-surgical complications, and sexual satisfaction after treatment. Sexual satisfaction was assessed by a simple question: How is your sex life? RESULTS: There were differences related to vaginal length before and after performing exercises in both Frank Group (initial vaginal length 2.4±2.0 cm versus 6.9±1.1 cm after treatment, p<0.0001) and Surgical Group (initial vaginal length 0.9±1.4 cm versus 8.0±0.8 cm after treatment, p<0.0001). Increased vaginal length was observed in Surgical Group compared to Frank Group (Frank Group=7.0±0.9 cm versus Surgical Group=8.0±0.8 cm, p=0.0005). Forty percent of Surgical Group women had surgical complications versus no complications with the Frank technique. All women reported to be satisfied with their sexual life. CONCLUSION: The present data indicate that both the surgical and Frank techniques are effective for the treatment of vaginal agenesis, resulting in the construction of a vagina that pewrmits sexual intercourse and sexual satisfaction. The favorable aspects of the Frank technique are related to its low cost and to the low rates of major complications.

5334 downloads

14.

Anticoagulation monitored by nursing consultations: thromboembolism and dyscrasia - prospective cohort
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Bosa, Maria Cecilia Pereira

; Lima, Dalmo Valério Machado de

; Espírito Santo, Fatima Helena do

; Câmara, Ana Carolina Gurgel

; Vidigal, Paula Dias

; Reis, Fernanda Faria

Online Brazilian Journal of Nursing

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dec 2011, Volume 10 N. 3 Pages 01 - 04

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Observational study, prospective cohort type with quantitative approach for occurrence analysis of hemorrhagic and thromboembolism outcomes on cardiopath patients carriers of metallic mechanical valves or chronic atrial fibrillation with warfarin in use, accompanied at an oral anticoagulation ambulatory of a Cardiology Institute in Rio de Janeiro City. OBJECTIVE: Evaluate the impact of orientations from Nursing Consultation as the occurrence of thrombotic or hemorrhagic effects. METHOD: Prospective non-probabilistic cohort sample of limited convenience to the temporal cutting between August 2011 and February 2012. The data treatment will be based on descriptive statistics and risk calculation for analysis of correlated variables: International Normalized Ratio, hemorrhagic and thromboembolism events.

Estudio observacional, tipo corte prospectivo con enfoque cuantitativo para análisis de la aparición de los resultados tromboembolicos y hemorrágicos de pacientes con enfermedades del corazón portadores de válvulas metálicas o fibrilación auricular crónica con warfarina, acompañados en una clínica de consulta externa seguido en la clínica de anticoagulación oral de un Instituto de Cardiología en el municipio de Rio de Janeiro. OBJETIVO: evaluar el impacto de las directrices en cuanto a su consulta de enfermería y a la ocurrencia d efectos trombólicos o hemorrágicos. MÉTODO: corte prospectiva muestra no probabilística de conveniencia para el periodo de tiempo limitado entre agosto de 2011 y febrero de 2012. El tratamiento de los datos estará basado en estadística descriptiva y el cálculo de riesgos para análisis de las variables correlacionadas: razón Normalizada Internacional, eventos hemorrágicos y tromboembolicos.

Estudo observacional, tipo coorte prospectivo com abordagem quantitativa para análise da ocorrência dos desfechos tromboembólicos e hemorrágicos de pacientes cardiopatas portadores de válvulas metálicas ou fibrilação atrial crônica em uso de varfarina, acompanhados no ambulatório de anticoagulação oral de um Instituto de Cardiologia no município do Rio de Janeiro. OBJETIVO: avaliar o impacto das orientações da Consulta de Enfermagem quanto à ocorrência dos efeitos trombóticos ou hemorrágico. MÉTODO: coorte prospectiva amostra não probabilística de conveniência limitada ao recorte temporal entre agosto de 2011 e fevereiro de 2012. O tratamento dos dados estará baseado em estatística descritiva e cálculo de riscos para análise das variáveis correlacionadas: Razão Normalizada Internacional, eventos hemorrágicos e tromboembólicos.

https://doi.org/10.5935/1676-4285.20113592 5 downloads

15.

The Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders: recruitment, assessment instruments, methods for the development of multicenter collaborative studies and preliminary results
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Miguel, Euripedes Constantino

; Ferrão, Ygor Arzeno

; Rosário, Maria Conceição do

; Mathis, Maria Alice de

; Torres, Albina Rodrigues

; Fontenelle, Leonardo Franklin

; Hounie, Ana Gabriela

; Shavitt, Roseli Gedanke

; Cordioli, Aristides Volpato

; Gonzalez, Christina Hojaij

; Petribú, Kátia

; Diniz, Juliana Belo

; Malavazzi, Dante Marino

; Torresan, Ricardo C

; Raffin, Andréa Litvin

; Meyer, Elisabeth

; Braga, Daniela T

; Borcato, Sonia

; Valério, Carolina

; Gropo, Luciana N

; Prado, Helena da Silva

; Perin, Eduardo Alliende

; Santos, Sandro Iêgo

; Copque, Helen

; Borges, Manuela Corrêa

; Lopes, Angélica Prazeres

; Silva, Elenita D da

Brazilian Journal of Psychiatry

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sep 2008, Volume 30 N. 3 Pages 185 - 196

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVO: Descrever o recrutamento de pacientes, instrumentos de avaliação, métodos para o desenvolvimento de estudos colaborativos multicêntricos e os resultados preliminares do Consórcio Brasileiro de Pesquisa em Transtornos do Espectro Obsessivo-Compulsivo, que inclui sete centros universitários. MÉTODO: Este estudo transversal incluiu entrevistas semi-estruturadas (dados sociodemográficos, histórico médico e psiquiátrico, curso da doença e diagnósticos psiquiátricos comórbidos) e instrumentos que avaliam os sintomas do transtorno obsessivo-compulsivo (Escala para Sintomas Obsessivo-Compulsivos de Yale-Brown e Escala Dimensional para Sintomas Obsessivo-Compulsivos de Yale-Brown), sintomas depressivos (Inventário de Depressão de Beck), sintomas ansiosos (Inventário de Ansiedade de Beck), fenômenos sensoriais (Escala de Fenômenos Sensoriais da Universidade de São Paulo), juízo crítico (Escala de Avaliação de Crenças de Brown), tiques (Escala de Gravidade Global de Tiques de Yale) e qualidade de vida (questionário genérico de avaliação de qualidade de vida, Medical Outcome Quality of Life Scale Short-form-36 e Escala de Avaliação Social). O treinamento dos avaliadores consistiu em assistir cinco entrevistas filmadas e entrevistar cinco pacientes junto com um pesquisador mais experiente, antes de entrevistar pacientes sozinhos. A confiabilidade entre todos os líderes de grupo para os instrumentos mais importantes (Structured Clinical Interview for DSM-IV, Dimensional Yale-Brown Obsessive-Compulsive Scale, Universidade de São Paulo Sensory Phenomena Scale ) foi medida após seis entrevistas completas. RESULTADOS: A confiabilidade entre avaliadores foi de 96%. Até março de 2008, 630 pacientes com transtorno obsessivo-compulsivo tinham sido sistematicamente avaliados. A média de idade (±SE) foi de 34,7 (±0,51), 56,3% eram do sexo feminino e 84,6% caucasianos. Os sintomas obsessivo-compulsivos mais prevalentes foram os de simetria e os de contaminação. As comorbidades psiquiátricas mais comuns foram depressão maior, ansiedade generalizada e transtorno de ansiedade social. O transtorno de controle de impulsos mais comum foi escoriação neurótica. CONCLUSÃO: Este consórcio de pesquisa, pioneiro no Brasil, permitiu delinear o perfil sociodemográfico, clínico e terapêutico do paciente com transtorno obsessivo-compulsivo em uma grande amostra clínica de pacientes. O Consórcio Brasileiro de Pesquisa em Transtornos do Espectro Obsessivo-Compulsivo estabeleceu uma importante rede de colaboração de investigação clínica padronizada sobre o transtorno obsessivo-compulsivo e pode abrir o caminho para projetos semelhantes destinados a integrar outros grupos de pesquisa no Brasil e em todo o mundo.

OBJECTIVE: To describe the recruitment of patients, assessment instruments, implementation, methods and preliminary results of The Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders, which includes seven university sites. METHOD: This cross-sectional study included a comprehensive clinical assessment including semi-structured interviews (sociodemographic data, medical and psychiatric history, disease course and comorbid psychiatric diagnoses), and instruments to assess obsessive-compulsive (Yale-Brown Obsessive-Compulsive Scale and Dimensional Yale-Brown Obsessive-Compulsive Scale), depressive (Beck Depression Inventory) and anxious (Beck Anxiety Inventory) symptoms, sensory phenomena (Universidade de São Paulo Sensory Phenomena Scale), insight (Brown Assessment Beliefs Scale), tics (Yale Global Tics Severity Scale) and quality of life (Medical Outcome Quality of Life Scale Short-form-36 and Social Assessment Scale). The raters' training consisted of watching at least five videotaped interviews and interviewing five patients with an expert researcher before interviewing patients alone. The reliability between all leaders for the most important instruments (Structured Clinical Interview for DSM-IV, Dimensional Yale-Brown Obsessive-Compulsive Scale, Universidade de São Paulo Sensory Phenomena Scale) was measured after six complete interviews. RESULTS: Inter-rater reliability was 96%. By March 2008, 630 obsessive-compulsive disorder patients had been systematically evaluated. Mean age (±SE) was 34.7 (±0.51), 56.3% were female, and 84.6% Caucasian. The most prevalent obsessive compulsive symptom dimensions were symmetry and contamination. The most common comorbidities were major depression, generalized anxiety and social anxiety disorder. The most common DSM-IV impulsive control disorder was skin picking. CONCLUSION: The sample was composed mainly by Caucasian individuals, unmarried, with some kind of occupational activity, mean age of 35 years, onset of obsessive-compulsive symptoms at 13 years of age, mild to moderate severity, mostly of symmetry, contamination/cleaning and comorbidity with depressive disorders. The Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders has established an important network for standardized collaborative clinical research in obsessive-compulsive disorder and may pave the way to similar projects aimed at integrating other research groups in Brazil and throughout the world.

10828 downloads Cited 12 times in SciELO

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