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Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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Boeger, Walter A.
; Valim, Michel P.
; Zaher, Hussam
; Rafael, José A.
; Forzza, Rafaela C.
; Percequillo, Alexandre R.
; Serejo, Cristiana S.
; Garraffoni, André R.S.
; Santos, Adalberto J.
; Slipinski, Adam
; Linzmeier, Adelita M.
; Calor, Adolfo R.
; Garda, Adrian A.
; Kury, Adriano B.
; Fernandes, Agatha C.S.
; Agudo-Padrón, Aisur I.
; Akama, Alberto
; Silva Neto, Alberto M. da
; Burbano, Alejandro L.
; Menezes, Aleksandra
; Pereira-Colavite, Alessandre
; Anichtchenko, Alexander
; Lees, Alexander C.
; Bezerra, Alexandra M.R.
; Domahovski, Alexandre C.
; Pimenta, Alexandre D.
; Aleixo, Alexandre L.P.
; Marceniuk, Alexandre P.
; Paula, Alexandre S. de
; Somavilla, Alexandre
; Specht, Alexandre
; Camargo, Alexssandro
; Newton, Alfred F.
; Silva, Aline A.S. da
; Santos, Aline B. dos
; Tassi, Aline D.
; Aragão, Allan C.
; Santos, Allan P.M.
; Migotto, Alvaro E.
; Mendes, Amanda C.
; Cunha, Amanda
; Chagas Júnior, Amazonas
; Sousa, Ana A.T. de
; Pavan, Ana C.
; Almeida, Ana C.S.
; Peronti, Ana L.B.G.
; Henriques-Oliveira, Ana L.
; Prudente, Ana L.
; Tourinho, Ana L.
; Pes, Ana M.O.
; Carmignotto, Ana P.
; Wengrat, Ana P.G. da Silva
; Dornellas, Ana P.S.
; Molin, Anamaria Dal
; Puker, Anderson
; Morandini, André C.
; Ferreira, André da S.
; Martins, André L.
; Esteves, André M.
; Fernandes, André S.
; Roza, André S.
; Köhler, Andreas
; Paladini, Andressa
; Andrade, Andrey J. de
; Pinto, Ângelo P.
; Salles, Anna C. de A.
; Gondim, Anne I.
; Amaral, Antonia C.Z.
; Rondón, Antonio A.A.
; Brescovit, Antonio
; Lofego, Antônio C.
; Marques, Antonio C.
; Macedo, Antonio
; Andriolo, Artur
; Henriques, Augusto L.
; Ferreira Júnior, Augusto L.
; Lima, Aurino F. de
; Barros, Ávyla R. de A.
; Brito, Ayrton do R.
; Romera, Bárbara L.V.
; Vasconcelos, Beatriz M.C. de
; Frable, Benjamin W.
; Santos, Bernardo F.
; Ferraz, Bernardo R.
; Rosa, Brunno B.
; Sampaio, Brunno H.L.
; Bellini, Bruno C.
; Clarkson, Bruno
; Oliveira, Bruno G. de
; Corrêa, Caio C.D.
; Martins, Caleb C.
; Castro-Guedes, Camila F. de
; Souto, Camilla
; Bicho, Carla de L.
; Cunha, Carlo M.
; Barboza, Carlos A. de M.
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; Barreto, Carlos
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; Mascarenhas, Carolina S.
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; Waichert, Cecilia
; Digiani, Celina
; Haddad, Célio F.B.
; Azevedo, Celso O.
; Benetti, Cesar J.
; Santos, Charles M.D. dos
; Bartlett, Charles R.
; Bonvicino, Cibele
; Ribeiro-Costa, Cibele S.
; Santos, Cinthya S.G.
; Justino, Cíntia E.L.
; Canedo, Clarissa
; Bonecker, Claudia C.
; Santos, Cláudia P.
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; Gonçalves, Clayton C.
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; Schwertner, Cristiano F.
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; Lucena, Daercio A. de A.
; Manfio, Daiara
; Amorim, Dalton de S.
; Queiroz, Dalva L. de
; Queiroz, Dalva L. de
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; Abbate, Daniel
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; Nogueira, David S.
; Marques, Dayse W.A.
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; Nishiyama, Eric Y.
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; Schunck, Fabio
; Godoi, Fábio S. P. de
; Machado, Fabrizio M.
; Barbo, Fausto E.
; Agrain, Federico A.
; Ribeiro, Felipe B.
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; Barbosa, Felipe F.
; Silva, Fenanda S.
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; Straube, Fernando C.
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; Mantellato, Fernando
; Vaz-de-Mello, Fernando Z.
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; Albuquerque, Flávio
; Molina, Flavio B.
; Passos, Flávio D.
; Shockley, Floyd W.
; Pinheiro, Francielly F.
; Mello, Francisco de A.G. de
; Nascimento, Francisco E. de L.
; Franco, Francisco L.
; Oliveira, Francisco L. de
; Melo, Francisco T. de V.
; Quijano, Freddy R.B.
; Salles, Frederico F.
; Biffi, Gabriel
; Queiroz, Gabriel C.
; Bizarro, Gabriel L.
; Hrycyna, Gabriela
; Leviski, Gabriela
; Powell, Gareth S.
; Santos, Geane B. dos
; Morse, Geoffrey E.
; Brown, George
; Mattox, George M.T.
; Zimbrão, Geraldo
; Carvalho, Gervásio S.
; Miranda, Gil F.G.
; Moraes, Gilberto J. de
; Lourido, Gilcélia M.
; Neves, Gilmar P.
; Moreira, Gilson R.P.
; Montingelli, Giovanna G.
; Maurício, Giovanni N.
; Marconato, Gláucia
; Lopez, Guilherme E.L.
; Silva, Guilherme L. da
; Muricy, Guilherme
; Brito, Guilherme R.R.
; Garbino, Guilherme S.T.
; Flores, Gustavo E.
; Graciolli, Gustavo
; Libardi, Gustavo S.
; Proctor, Heather C.
; Gil-Santana, Helcio R.
; Varella, Henrique R.
; Escalona, Hermes E.
; Schmitz, Hermes J.
; Rodrigues, Higor D.D.
; Galvão Filho, Hilton de C.
; Quintino, Hingrid Y.S.
; Pinto, Hudson A.
; Rainho, Hugo L.
; Miyahira, Igor C.
; Gonçalves, Igor de S.
; Martins, Inês X.
; Cardoso, Irene A.
; Oliveira, Ismael B. de
; Franz, Ismael
; Fernandes, Itanna O.
; Golfetti, Ivan F.
; S. Campos-Filho, Ivanklin
; Oliveira, Ivo de S.
; Delabie, Jacques H.C.
; Oliveira, Jader de
; Prando, Jadila S.
; Patton, James L.
; Bitencourt, Jamille de A.
; Silva, Janaina M.
; Santos, Jandir C.
; Arruda, Janine O.
; Valderrama, Jefferson S.
; Dalapicolla, Jeronymo
; Oliveira, Jéssica P.
; Hájek, Jiri
; Morselli, João P.
; Narita, João P.
; Martin, João P.I.
; Grazia, Jocélia
; McHugh, Joe
; Cherem, Jorge J.
; Farias Júnior, José A.S.
; Fernandes, Jose A.M.
; Pacheco, José F.
; Birindelli, José L.O.
; Rezende, José M.
; Avendaño, Jose M.
; Duarte, José M. Barbanti
; Ribeiro, José R. Inácio
; Mermudes, José R.M.
; Pujol-Luz, José R.
; Santos, Josenilson R. dos
; Câmara, Josenir T.
; Teixeira, Joyce A.
; Prado, Joyce R. do
; Botero, Juan P.
; Almeida, Julia C.
; Kohler, Julia
; Gonçalves, Julia P.
; Beneti, Julia S.
; Donahue, Julian P.
; Alvim, Juliana
; Almeida, Juliana C.
; Segadilha, Juliana L.
; Wingert, Juliana M.
; Barbosa, Julianna F.
; Ferrer, Juliano
; Santos, Juliano F. dos
; Kuabara, Kamila M.D.
; Nascimento, Karine B.
; Schoeninger, Karine
; Campião, Karla M.
; Soares, Karla
; Zilch, Kássia
; Barão, Kim R.
; Teixeira, Larissa
; Sousa, Laura D. do N.M. de
; Dumas, Leandro L.
; Vieira, Leandro M.
; Azevedo, Leonardo H.G.
; Carvalho, Leonardo S.
; Souza, Leonardo S. de
; Rocha, Leonardo S.G.
; Bernardi, Leopoldo F.O.
; Vieira, Letícia M.
; Johann, Liana
; Salvatierra, Lidianne
; Oliveira, Livia de M.
; Loureiro, Lourdes M.A. El-moor
; Barreto, Luana B.
; Barros, Luana M.
; Lecci, Lucas
; Camargos, Lucas M. de
; Lima, Lucas R.C.
; Almeida, Lucia M.
; Martins, Luciana R.
; Marinoni, Luciane
; Moura, Luciano de A.
; Lima, Luciano
; Naka, Luciano N.
; Miranda, Lucília S.
; Salik, Lucy M.
; Bezerra, Luis E.A.
; Silveira, Luis F.
; Campos, Luiz A.
; Castro, Luiz A.S. de
; Pinho, Luiz C.
; Silveira, Luiz F.L.
; Iniesta, Luiz F.M.
; Tencatt, Luiz F.C.
; Simone, Luiz R.L.
; Malabarba, Luiz R.
; Cruz, Luiza S. da
; Sekerka, Lukas
; Barros, Lurdiana D.
; Santos, Luziany Q.
; Skoracki, Maciej
; Correia, Maira A.
; Uchoa, Manoel A.
; Andrade, Manuella F.G.
; Hermes, Marcel G.
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; Lima, Sheila P.
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; Thiengo, Silvana C.
; Cohen, Simone C.
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; Pacheco, Thaynara L.
; Martins, Thiago F.
; Alvarenga, Thiago M.
; Carvalho, Thiago R. de
; Polizei, Thiago T.S.
; McElrath, Thomas C.
; Henry, Thomas
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; Amaral, Vanessa S. do
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; Wolff, Vera R. dos S.
; Slobodian, Verônica
; Silva, Vinícius B. da
; Espíndola, Vinicius C.
; Costa-Silva, Vinicius da
; Bertaco, Vinicius de A.
; Padula, Vinícius
; Ferreira, Vinicius S.
; Silva, Vitor C.P. da
; Piacentini, Vítor de Q.
; Sandoval-Gómez, Vivian E.
; Trevine, Vivian
; Sousa, Viviane R.
; Sant’Anna, Vivianne B. de
; Mathis, Wayne N.
; Souza, Wesley de O.
; Colombo, Wesley D.
; Tomaszewska, Wioletta
; Wosiacki, Wolmar B.
; Ovando, Ximena M.C.
; Leite, Yuri L.R.
.
ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7
2.
Evaluation of (-)-Fenchone antimicrobial activity against oral Candida albicans and toxicological parameters: an in silico, in vitro and ex vivo study Fenchone parameters silico
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SANTOS, ANDRÉ A. DOS
; OLIVEIRA-FILHO, ABRAHÃO A. DE
; TEIXEIRA, BRÁULIO A.
; GALVÃO, JOSÉ LUCAS F.M.
; MEDEIROS, MARIA ALICE A. DE
; ALVES, MILLENA S.
; BARBOSA, DAVID HENRIQUE X.
; MAFRA, RODRIGO P.
; VASCONCELOS, ULRICH
; LIMA, EDELTRUDES O.
.
Abstract Candida albicans is the primary species causing oral candidiasis. Its increasing drug resistance drives the search for more effective antifungal agents. Therefore, we assessed toxicological parameters and the antimicrobial activity and mechanisms of action of the monoterpene (-)-fenchone against oral C. albicans. We conducted an in silico study using PASS online and AdmetSAR, followed by evaluation of antifungal activity through Minimum Inhibitory Concentration (MIC), Minimum Fungicidal Concentration (MFC), association study with miconazole, and assays with sorbitol and ergosterol. Inhibition of biofilm formation and disruption of preformed biofilm were considered. Toxicity was also assessed through hemolysis assay. The in silico study revealed a higher likelihood of the compound being active for antifungal activity, as well as promising pharmacokinetic and toxicity characteristics. Subsequently, (-)-fenchone exhibited predominantly fungicidal activity (MIC90 = 8 μg/mL; MFC = 16 μg/mL), including against miconazole-resistant C. albicans isolates. The substance does not appear to act by damaging the fungal cell wall or plasma membrane, and exhibited synergy with miconazole. There was activity in inhibiting biofilm formation but not in disrupting preformed biofilm. Finally, the product exerted low hemolytic activity at more than MIC×10. Based on these results, (-)-fenchone may represent a promising therapeutic alternative for oral candidiasis. candidiasis agents Therefore fenchone C AdmetSAR MIC, MIC , (MIC) MFC, (MFC) miconazole ergosterol considered assay characteristics Subsequently MIC90 (MIC9 μg/mL μgmL μg mL 1 μg/mL, μg/mL) miconazoleresistant resistant isolates membrane Finally MIC10 10 MIC×10 results (MIC (MFC MIC9 MIC1 MIC×1 MIC×
3.
Narrow mycorrhizae and large non-mycorrhizal fungal diversity associated with roots of Cattleya milleri, an endemic and endangered orchid from a rupestrian hotspot in the “Quadrilátero Ferrífero” of Minas Gerais - Brazil nonmycorrhizal non mycorrhizal milleri Quadrilátero Ferrífero
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Pereira, Marlon Corrêa
; Cunha, Paloma Cavalcante
; Teixeira, Anita Fernanda dos Santos
; Silva, Leandro Israel da
; Valadares, Rafael Borges da Silva
; Dória, Joyce
; Costa, Paulo Henrique de Oliveira
; Moreira, Fatima Maria de Souza
.
Abstract The threatened orchid Cattleya milleri is a microendemic orchid of a Brazilian savanna hotspot. As endophytes and mycorrhizae may improve its propagation and conservation, we investigated its root fungal community. Cattleya milleri roots were sampled in five natural sites and at a greenhouse. Fungal root endophytes were isolated for characterization and molecular ITS (Internal Transcribed Spacer) identification. Total DNA was extracted from endorhiza and rhizosphere for ITS amplification and sequencing. Sixteen fungal isolates were clustered in 6 Operational Taxonomic Units (OTUs) and endorhizal and rhizospheric sequences were clustered in 327 OTUs. Endorhiza presented from 25 to 89 OTUs, and rhizosphere 56 OTUs. Cluster analysis showed high divergence between natural and greenhouse fungal communities, but similarity among natural samples. From the 94 genera, 24 were annotated as endophytes, two mycorrhizas, 33 pathotrophs, 40 saprotrophs, and 17 symbiotrophs based on the FunGuild database. Endophytes of the orders Capnodiales, Hypocreales, Pleosporales, and mycorrhizae of Sebacinales occurred in all sites. The mycorrhizae Tulasnella occurred in all natural samples. The interaction with only two mycorrhizal taxa may limit C. milleri distribution. However, the recruitment of many non-mycorrhizal endophytes is essential to natural development. Pleosporales, Tulasnella, and Sebacinalles may be considered for C. milleri propagation and conservation. hotspot conservation community Internal Spacer identification sequencing OTUs (OTUs 32 2 8 5 communities samples 9 genera mycorrhizas 3 pathotrophs 4 saprotrophs 1 database Capnodiales Hypocreales Pleosporales C distribution However nonmycorrhizal non development
4.
HIGH-DENSITY LIPOPROTEIN CHOLESTEROL AND SYSTEMIC ARTERIAL HYPERTENSION ARE ASSOCIATED WITH HEPATIC NECROINFLAMMATORY ACTIVITY IN PATIENTS WITH CHRONIC HEPATITIS C HIGHDENSITY HIGH DENSITY
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SOUZA, Gustavo Henrique De Puy e
; SILVA, Luciana Diniz
; VIEIRA, Diego Alves
; ROCHA, Gifone Aguiar
; LIMA, Agnaldo Soares
; VIDIGAL, Paula Vieira Teixeira
.
RESUMO Contexto: Aproximadamente 71 milhões de pessoas estão infectadas pelo vírus da hepatite C em todo o mundo. Um número significativo desses indivíduos desenvolverá cirrose hepática e/ou carcinoma hepatocelular. Além do fígado, há evidências científicas que associam doenças cardiovasculares e hepatite C crônica; no entanto, os mecanismos biológicos implicados na ocorrência dessas condições ainda não foram completamente esclarecidos. Objetivo: Avaliar a associação entre histologia hepática, comorbidades clínicas e perfil lipídico em pacientes com hepatite C crônica. Investigar associações entre histologia hepática e parâmetros demográficos, nutricionais, bioquímicos e virológicos. Métodos: Oitenta e cinco pacientes com hepatite C crônica foram prospectivamente submetidos à biópsia hepática. Biópsias hepáticas foram obtidas de cada paciente por via percutânea com agulha de Menghini. A fibrose foi avaliada de acordo com o sistema de pontuação METAVIR, como segue: F0, sem fibrose; F1, expansão portal fibrosa; F2, alargamento portal fibroso com poucos septos; F3, fibrose em ponte com distorção arquitetônica; e F4, cirrose hepática. A atividade foi classificada com base no grau de infiltração de linfócitos e necrose de hepatócitos, de A0 a A3. O diagnóstico da doença hepática foi baseado em métodos clínicos, bioquímicos, histológicos e radiológicos. Os dados foram analisados por modelos de regressão logística. Resultados: Neste estudo transversal, realizado em um ambulatório do hospital universitário, foram incluídos 85 pacientes que tinham média de idade de 57,2±10,7 anos, sendo 45 (52,9%) do sexo feminino. Havia 10 pacientes com cirrose. Os pacientes com METAVIR F3-F4 eram significativamente mais velhos (P=0,02) e tinham níveis mais elevados de ALT (P=0,0006), AST (P<0,0001), γ-GT (P=0,03) e bilirrubina (P=0,001) e, maior tempo de protrombina do que pacientes com escore F0-F2. Os níveis de albumina (P=0,01) foram significativamente mais baixos naqueles classificados como METAVIR F3-F4. Idade (OR=1,09; IC95%=1,02-1,16; P=0,02), esteatose (OR=4,03; IC95%=1,05-15,45; P=0,04) e HDL-C <60 mg/dL (OR=7,67; 95%IC=1,71-34,49; P=0,008) foram independentemente associados à fibrose. Hipertensão (OR=6,36; IC95%=1,31-30,85; P=0,02) e HDL-C <60 mg/dL (OR=9,85; IC95%=2,35-41,39; P=0,002) foram independentemente associados à atividade necroinflamatória. Hipertensão (OR=6,94; IC 95%=1,92-25,05; P=0,003) e HDL-C <60 mg/dL (OR=3,94; IC95%=1,27-12,3; P=0,02) foram associados à atividade inflamatória de interface. Os triglicerídeos (TG >150 mg/dL) permaneceram associados à atividade inflamatória lobular. Conclusão: Níveis de coleterol HDL <60 mg/dL foram independentemente associados à atividade necroinflamatória na hepatite C crônica. Pacientes com hipertensão têm risco aumentado de desenvolver atividade necroinflamatória. Contexto 7 mundo eou ou hepatocelular fígado entanto esclarecidos Objetivo demográficos nutricionais virológicos Métodos Menghini segue F0 F F1 fibrosa F2 septos F3 arquitetônica F4 hepatócitos A3 clínicos radiológicos logística Resultados transversal universitário 8 572107 57 2 57,2±10, anos 4 52,9% 529 52 9 (52,9% feminino 1 F3F4 FF F3-F P=0,02 P002 P 0 02 (P=0,02 P=0,0006, P00006 P=0,0006 , 0006 (P=0,0006) P<0,0001, P00001 P<0,0001 0001 (P<0,0001) γGT γ GT P=0,03 P003 03 (P=0,03 P=0,001 P0001 001 (P=0,001 F0F2. F0F2 F2. F0-F2 P=0,01 P001 01 (P=0,01 F3F4. F4. OR=1,09 OR109 OR 09 (OR=1,09 IC95%=1,021,16 IC95102116 IC95%=1,02 1,16 IC95 16 IC95%=1,02-1,16 P=0,02, OR=4,03 OR403 (OR=4,03 IC95%=1,0515,45 IC951051545 IC95%=1,05 15,45 05 15 IC95%=1,05-15,45 P=0,04 P004 04 HDLC 60 <6 mgdL mg dL OR=7,67 OR767 67 (OR=7,67 95%IC=1,7134,49 95IC1713449 95%IC=1,71 34,49 95 34 49 95%IC=1,71-34,49 P=0,008 P0008 008 OR=6,36 OR636 6 36 (OR=6,36 IC95%=1,3130,85 IC951313085 IC95%=1,31 30,85 31 30 IC95%=1,31-30,85 OR=9,85 OR985 (OR=9,85 IC95%=2,3541,39 IC952354139 IC95%=2,35 41,39 35 41 39 IC95%=2,35-41,39 P=0,002 P0002 002 OR=6,94 OR694 94 (OR=6,94 95%=1,9225,05 951922505 95%=1,92 25,05 92 25 95%=1,92-25,05 P=0,003 P0003 003 OR=3,94 OR394 3 (OR=3,94 IC95%=1,2712,3 IC95127123 IC95%=1,27 12,3 27 12 IC95%=1,27-12,3 interface TG 150 >15 lobular Conclusão 57210 5 57,2±10 52,9 (52,9 F3F P=0,0 P00 (P=0,0 P0000 P=0,000 000 (P=0,0006 P<0,000 (P<0,0001 P=0,00 P000 00 (P=0,00 F0F F0-F OR=1,0 OR10 (OR=1,0 021 IC95%=1,021,1 IC9510211 IC95102 IC95%=1,0 116 1,1 IC9 IC95%=1,02-1,1 OR=4,0 OR40 (OR=4,0 0515 IC95%=1,0515,4 IC95105154 IC95105 1545 15,4 IC95%=1,05-15,4 < OR=7,6 OR76 (OR=7,6 7134 95%IC=1,7134,4 95IC171344 95IC171 95%IC=1,7 3449 34,4 95%IC=1,71-34,4 OR=6,3 OR63 (OR=6,3 3130 IC95%=1,3130,8 IC95131308 IC95131 IC95%=1,3 3085 30,8 IC95%=1,31-30,8 OR=9,8 OR98 (OR=9,8 3541 IC95%=2,3541,3 IC95235413 IC95235 IC95%=2,3 4139 41,3 IC95%=2,35-41,3 OR=6,9 OR69 (OR=6,9 9225 95%=1,9225,0 95192250 95192 95%=1,9 2505 25,0 95%=1,92-25,0 OR=3,9 OR39 (OR=3,9 2712 IC95%=1,2712, IC9512712 IC95127 IC95%=1,2 123 12, IC95%=1,27-12, >1 5721 57,2±1 52, (52, P=0, P0 (P=0, (P=0,000 P<0,00 (P<0,000 OR=1, OR1 (OR=1, IC95%=1,021, IC951021 IC9510 IC95%=1, 11 1, IC95%=1,02-1, OR=4, OR4 (OR=4, 051 IC95%=1,0515, IC9510515 154 15, IC95%=1,05-15, OR=7, OR7 (OR=7, 713 95%IC=1,7134, 95IC17134 95IC17 95%IC=1, 344 34, 95%IC=1,71-34, OR=6, OR6 (OR=6, 313 IC95%=1,3130, IC9513130 IC9513 308 30, IC95%=1,31-30, OR=9, OR9 (OR=9, 354 IC95%=2,3541, IC9523541 IC9523 IC95%=2, 413 41, IC95%=2,35-41, 922 95%=1,9225, 9519225 9519 95%=1, 250 25, 95%=1,92-25, OR=3, OR3 (OR=3, 271 IC95%=1,2712 IC951271 IC9512 IC95%=1,27-12 > 572 57,2± (52 P=0 (P=0 P<0,0 (P<0,00 OR=1 (OR=1 IC95%=1,021 IC951 IC95%=1 IC95%=1,02-1 OR=4 (OR=4 IC95%=1,0515 IC951051 IC95%=1,05-15 OR=7 (OR=7 95%IC=1,7134 95IC1713 95IC1 95%IC=1 95%IC=1,71-34 OR=6 (OR=6 IC95%=1,3130 IC951313 IC95%=1,31-30 OR=9 (OR=9 IC95%=2,3541 IC952354 IC952 IC95%=2 IC95%=2,35-41 95%=1,9225 951922 951 95%=1 95%=1,92-25 OR=3 (OR=3 IC95%=1,271 IC95%=1,27-1 57,2 (5 P= (P= P<0, (P<0,0 OR= (OR= IC95%= IC95%=1,02- IC95%=1,051 IC95%=1,05-1 95%IC=1,713 95IC 95%IC= 95%IC=1,71-3 IC95%=1,313 IC95%=1,31-3 IC95%=2,354 IC95%=2,35-4 95%=1,922 95%= 95%=1,92-2 IC95%=1,27- 57, ( (P P<0 (P<0, (OR IC95% IC95%=1,05- 95%IC 95%IC=1,71- IC95%=1,31- IC95%=2,35- 95% 95%=1,92- P< (P<0 (P<
ABSTRACT Background: Approximately 71 million people are chronically infected with hepatitis C virus (HCV) worldwide. A significant number of these individuals will develop liver cirrhosis and/or hepatocellular carcinoma. Beyond the liver, there is a sizeable body of scientific evidence linking cardiovascular disease and chronic hepatitis C (CHC); however, the biological mechanisms behind the concurrence of these conditions have not been completely clarified yet. Objective: To evaluate associations between hepatic histology, clinical comorbidities and lipid profile in patients with CHC. To investigate associations between liver histology and demographic, nutritional, biochemical and virological parameters. Methods: Eight-five patients with CHC prospectively underwent hepatic biopsy. Liver fragments were obtained from each patient by percutaneous route using a Menghini needle. Fibrosis was evaluated according to the METAVIR scoring system, as follows: F0, no fibrosis; F1, fibrous portal expansion; F2, fibrous portal widening with few septa; F3, bridging fibrosis with architectural distortion; and F4, liver cirrhosis. The activity was classified based on the degree of lymphocyte infiltration and hepatocyte necrosis, from A0 to A3. The diagnosis of liver disease was based on clinical, biochemical, histological, and radiological methods. The data were analyzed by logistic regression models. Results: This cross-sectional study included 85 outpatients followed at the tertiary care ambulatory centre with a mean age of 57.2±10.7 years and 45 (52.9%) were females. There were 10 patients with cirrhosis. Patients with a METAVIR F3-F4 were significantly older (P=0.02) and had higher levels of ALT (P=0.0006), AST (P<0.0001), γ-GT (P=0.03) and bilirubin (P=0.001) and higher prothrombin time than patients with F0-F2 score. Albumin levels (P=0.01) were significantly lower in METAVIR F3-F4. Age (OR=1.09; 95%CI=1.02-1.16; P=0.02), steatosis (OR=4.03; 95%CI=1.05-15.45; P=0.04) and high-density lipoprotein cholesterol (HDL-C) <60 mg/dL (OR=7.67; 95%CI=1.71-34.49; P=0.008) were independently associated with fibrosis. Hypertension (OR=6.36; 95%CI=1.31-30.85; P=0.02) and HDL-C <60 mg/dL (OR=9.85; 95%CI=2.35-41.39; P=0.002) were independently associated with necroinflammatory activity. Hypertension (OR=6.94; 95%CI=1.92-25.05; P=0.003) and HDL-C <60 mg/dL (OR=3.94; 95%CI=1.27-12.3; P=0.02) were associated with interface inflammatory activity. Triglycerides (TG ≥150 mg/dL) remained associated with lobular inflammatory activity. Conclusion: cholesterol levels <60 mg/dL were independently associated with necroinflammatory activity in chronic hepatitis C. Patients with hypertension are at an increased risk of developing necroinflammatory activity. Background 7 HCV (HCV worldwide andor or carcinoma (CHC) however yet Objective demographic nutritional parameters Methods Eightfive Eight five biopsy needle system follows F0 F F1 expansion F2 septa F3 distortion F4 necrosis A3 histological methods models Results crosssectional cross sectional 8 572107 57 2 57.2±10. 4 52.9% 529 52 9 (52.9% females 1 F3F4 FF F3-F P=0.02 P002 P 0 02 (P=0.02 P=0.0006, P00006 P=0.0006 , 0006 (P=0.0006) P<0.0001, P00001 P<0.0001 0001 (P<0.0001) γGT γ GT P=0.03 P003 03 (P=0.03 P=0.001 P0001 001 (P=0.001 F0F2 F0-F score P=0.01 P001 01 (P=0.01 F3F4. F4. OR=1.09 OR109 OR 09 (OR=1.09 95%CI=1.021.16 95CI102116 CI 95%CI=1.02 1.16 95 16 95%CI=1.02-1.16 P=0.02, OR=4.03 OR403 (OR=4.03 95%CI=1.0515.45 95CI1051545 95%CI=1.05 15.45 05 15 95%CI=1.05-15.45 P=0.04 P004 04 highdensity high density HDLC HDL (HDL-C 60 <6 mgdL mg dL OR=7.67 OR767 67 (OR=7.67 95%CI=1.7134.49 95CI1713449 95%CI=1.71 34.49 34 49 95%CI=1.71-34.49 P=0.008 P0008 008 OR=6.36 OR636 6 36 (OR=6.36 95%CI=1.3130.85 95CI1313085 95%CI=1.31 30.85 31 30 95%CI=1.31-30.85 OR=9.85 OR985 (OR=9.85 95%CI=2.3541.39 95CI2354139 95%CI=2.35 41.39 35 41 39 95%CI=2.35-41.39 P=0.002 P0002 002 OR=6.94 OR694 94 (OR=6.94 95%CI=1.9225.05 95CI1922505 95%CI=1.92 25.05 92 25 95%CI=1.92-25.05 P=0.003 P0003 003 OR=3.94 OR394 3 (OR=3.94 95%CI=1.2712.3 95CI127123 95%CI=1.27 12.3 27 12 95%CI=1.27-12.3 TG 150 ≥15 Conclusion (CHC 57210 5 57.2±10 52.9 (52.9 F3F P=0.0 P00 (P=0.0 P0000 P=0.000 000 (P=0.0006 P<0.000 (P<0.0001 P=0.00 P000 00 (P=0.00 F0F OR=1.0 OR10 (OR=1.0 021 95%CI=1.021.1 95CI10211 95CI102 95%CI=1.0 116 1.1 95%CI=1.02-1.1 OR=4.0 OR40 (OR=4.0 0515 95%CI=1.0515.4 95CI105154 95CI105 1545 15.4 95%CI=1.05-15.4 < OR=7.6 OR76 (OR=7.6 7134 95%CI=1.7134.4 95CI171344 95CI171 95%CI=1.7 3449 34.4 95%CI=1.71-34.4 OR=6.3 OR63 (OR=6.3 3130 95%CI=1.3130.8 95CI131308 95CI131 95%CI=1.3 3085 30.8 95%CI=1.31-30.8 OR=9.8 OR98 (OR=9.8 3541 95%CI=2.3541.3 95CI235413 95CI235 95%CI=2.3 4139 41.3 95%CI=2.35-41.3 OR=6.9 OR69 (OR=6.9 9225 95%CI=1.9225.0 95CI192250 95CI192 95%CI=1.9 2505 25.0 95%CI=1.92-25.0 OR=3.9 OR39 (OR=3.9 2712 95%CI=1.2712. 95CI12712 95CI127 95%CI=1.2 123 12. 95%CI=1.27-12. ≥1 5721 57.2±1 52. (52. P=0. P0 (P=0. (P=0.000 P<0.00 (P<0.000 OR=1. OR1 (OR=1. 95%CI=1.021. 95CI1021 95CI10 95%CI=1. 11 1. 95%CI=1.02-1. OR=4. OR4 (OR=4. 051 95%CI=1.0515. 95CI10515 154 15. 95%CI=1.05-15. OR=7. OR7 (OR=7. 713 95%CI=1.7134. 95CI17134 95CI17 344 34. 95%CI=1.71-34. OR=6. OR6 (OR=6. 313 95%CI=1.3130. 95CI13130 95CI13 308 30. 95%CI=1.31-30. OR=9. OR9 (OR=9. 354 95%CI=2.3541. 95CI23541 95CI23 95%CI=2. 413 41. 95%CI=2.35-41. 922 95%CI=1.9225. 95CI19225 95CI19 250 25. 95%CI=1.92-25. OR=3. OR3 (OR=3. 271 95%CI=1.2712 95CI1271 95CI12 95%CI=1.27-12 ≥ 572 57.2± (52 P=0 (P=0 P<0.0 (P<0.00 OR=1 (OR=1 95%CI=1.021 95CI1 95%CI=1 95%CI=1.02-1 OR=4 (OR=4 95%CI=1.0515 95CI1051 95%CI=1.05-15 OR=7 (OR=7 95%CI=1.7134 95CI1713 95%CI=1.71-34 OR=6 (OR=6 95%CI=1.3130 95CI1313 95%CI=1.31-30 OR=9 (OR=9 95%CI=2.3541 95CI2354 95CI2 95%CI=2 95%CI=2.35-41 95%CI=1.9225 95CI1922 95%CI=1.92-25 OR=3 (OR=3 95%CI=1.271 95%CI=1.27-1 57.2 (5 P= (P= P<0. (P<0.0 OR= (OR= 95CI 95%CI= 95%CI=1.02- 95%CI=1.051 95%CI=1.05-1 95%CI=1.713 95%CI=1.71-3 95%CI=1.313 95%CI=1.31-3 95%CI=2.354 95%CI=2.35-4 95%CI=1.922 95%CI=1.92-2 95%CI=1.27- 57. ( (P P<0 (P<0. (OR 95%CI 95%CI=1.05- 95%CI=1.71- 95%CI=1.31- 95%CI=2.35- 95%CI=1.92- P< (P<0 (P<
5.
[SciELO Preprints] - Guideline of the Brazilian Society of Cardiology on Diagnosis and Treatment of Patients with Chagas Disease Cardiomyopathy
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Marin-Neto, José Antonio
Rassi Jr., Anis
Moraes Oliveira, Gláucia M.
Lemos Correia, Luís Claudio
Novaes Ramos Jr., Alberto
Hasslocher-Moreno, Alejandro Marcel
Luquetti Ostermayer, Alejandro
Sousa, Andréa Silvestre de
Amato Vincenzo de Paola, Angelo
Sobral de Sousa, Antonio Carlos
Pinho Ribeiro, Antonio Luiz
Correia Filho, Dalmo
Moraes de Souza, Dilma do Socorro
Cunha-Neto, Edecio
J. A. Ramires, Felix
Bacal, Fernando
Pereira Nunes, Maria do Carmo
Martinelli Filho, Martino
Ibrahim Scanavacca, Maurício
Magalhães Saraiva, Roberto
Alves de Oliveira Júnior, Wilson
M. Lorga-Filho, Adalberto
de Jesus Benevides de Almeida Guimarães, Adriana
Lopes Latado Braga, Adriana
Sarmento de Oliveira, Adriana
V. L. Sarabanda, Alvaro
Yecê das Neves Pinto, Ana
Assis Lopes do Carmo, André
Schmidt, André
Costa, Andréa Rodrigues da
Ianni, Barbara Maria
Markman Filho, Brivaldo
Eduardo Rochitte, Carlos
Thé Macedo, Carolina
Mady, Charles
Chevillard, Christophe
Bittencourt das Virgens, Cláudio Marcelo
Nery de Castro, Cleudson
De Paoli de Carvalho Britto, Constança Felícia
Pisani, Cristiano
do Carmo Rassi, Daniela
C. Sobral Filho, Dario
Rodrigues Almeida, Dirceu
A. Bocchi, Edimar
T. Mesquita, Evandro
de Souza Nogueira Sardinha Mendes, Fernanda
Pereira, Francisca Tatiana
Sperandio da Silva, Gilberto Marcelo
de Lima Peixoto, Giselle
Glotz de Lima, Gustavo
H. Veloso, Henrique
Turin Moreira, Henrique
Bellotti Lopes, Hugo
Masciarelli Francisco Pinto, Ibraim
Pinto Dias, João Carlos
Bemfica, João Marcos
Silva-Nunes, João Paulo
Soares Barreto-Filho, José Augusto
Kerr Saraiva, José Francisco
Lannes-Vieira, Joseli
Menezes Oliveira, Joselina Luzia
V. Armaganijan, Luciana
Martins, Luiz Cláudio
C. Sangenis, Luiz Henrique
Barbosa, Marco Paulo
Almeida-Santos, Marcos Antônio
Simões, Marcos Vinicius
Shikanai-Yasuda, Maria Aparecida
Vieira Moreira, Maria da Consolação
Higuchi, Maria de Lourdes
Costa Monteiro, Maria Rita de Cássia
Felix Mediano, Mauro Felippe
Maia Lima, Mayara
T. Oliveira, Maykon
Moreira Dias Romano , Minna
Nitz, Nadjar
de Tarso Jorge Medeiros, Paulo
Vieira Alves, Renato
Alkmim Teixeira, Ricardo
Coury Pedrosa, Roberto
Aras, Roque
Morais Torres, Rosália
dos Santos Povoa, Rui Manoel
Rassi, Sérgio Gabriel
Salles Xavier, Sérgio
Marinho Martins Alves , Silvia
B. N. Tavares, Suelene
Lima Palmeira, Swamy
da Silva Junior, Telêmaco Luiz
da Rocha Rodrigues, Thiago
Madrini Junior, Vagner
Maia da Costa , Veruska
Dutra, Walderez
This guideline aimed to update the concepts and formulate the standards of conduct and scientific evidence that support them, regarding the diagnosis and treatment of the Cardiomyopathy of Chagas disease, with special emphasis on the rationality base that supported it.nbsp;
Chagas disease in the 21st century maintains an epidemiological pattern of endemicity in 21 Latin American countries. Researchers and managers from endemic and non-endemic countries point to the need to adopt comprehensive public health policies to effectively control the interhuman transmission of T. cruzi infection, and to obtain an optimized level of care for already infected individuals, focusing on diagnostic and therapeutic opportunistic opportunities.
nbsp;
Pathogenic and pathophysiological mechanisms of the Cardiomyopathy of Chagas disease were revisited after in-depth updating and the notion that necrosis and fibrosis are stimulated by tissue parasitic persistence and adverse immune reaction, as fundamental mechanisms, assisted by autonomic and microvascular disorders, was well established. Some of them have recently formed potential targets of therapies.nbsp;
The natural history of the acute and chronic phases was reviewed, with enhancement for oral transmission, indeterminate form and chronic syndromes. Recent meta-analyses of observational studies have estimated the risk of evolution from acute and indeterminate forms and mortality after chronic cardiomyopathy. Therapeutic approaches applicable to individuals with Indeterminate form of Chagas disease were specifically addressed. All methods to detect structural and/or functional alterations with various cardiac imaging techniques were also reviewed, with recommendations for use in various clinical scenarios. Mortality risk stratification based on the Rassi score, with recent studies of its application, was complemented by methods that detect myocardial fibrosis.nbsp;
The current methodology for etiological diagnosis and the consequent implications of trypanonomic treatment deserved a comprehensive and in-depth approach. Also the treatment of patients at risk or with heart failure, arrhythmias and thromboembolic events, based on pharmacological and complementary resources, received special attention. Additional chapters supported the conducts applicable to several special contexts, including t. cruzi/HIV co-infection, risk during surgeries, in pregnant women, in the reactivation of infection after heart transplantation, and others.nbsp; nbsp;nbsp;
Finally, two chapters of great social significance, addressing the structuring of specialized services to care for individuals with the Cardiomyopathy of Chagas disease, and reviewing the concepts of severe heart disease and its medical-labor implications completed this guideline.
Esta diretriz teve como objetivo principal atualizar os conceitos e formular as normas de conduta e evidências científicas que as suportam, quanto ao diagnóstico e tratamento da CDC, com especial ênfase na base de racionalidade que a embasou.
A DC no século XXI mantém padrão epidemiológico de endemicidade em 21 países da América Latina. Investigadores e gestores de países endêmicos e não endêmicos indigitam a necessidade de se adotarem políticas abrangentes, de saúde pública, para controle eficaz da transmissão inter-humanos da infecção pelo T. cruzi, e obter-se nível otimizado de atendimento aos indivíduos já infectados, com foco em oportunização diagnóstica e terapêutica.
Mecanismos patogênicos e fisiopatológicos da CDC foram revisitados após atualização aprofundada e ficou bem consolidada a noção de que necrose e fibrose sejam estimuladas pela persistência parasitária tissular e reação imune adversa, como mecanismos fundamentais, coadjuvados por distúrbios autonômicos e microvasculares. Alguns deles recentemente constituíram alvos potenciais de terapêuticas.
A história natural das fases aguda e crônica foi revista, com realce para a transmissão oral, a forma indeterminada e as síndromes crônicas. Metanálises recentes de estudos observacionais estimaram o risco de evolução a partir das formas aguda e indeterminada e de mortalidade após instalação da cardiomiopatia crônica. Condutas terapêuticas aplicáveis aos indivíduos com a FIDC foram abordadas especificamente. Todos os métodos para detectar alterações estruturais e/ou funcionais com variadas técnicas de imageamento cardíaco também foram revisados, com recomendações de uso nos vários cenários clínicos. Estratificação de risco de mortalidade fundamentada no escore de Rassi, com estudos recentes de sua aplicação, foi complementada por métodos que detectam fibrose miocárdica.
A metodologia atual para diagnóstico etiológico e as consequentes implicações do tratamento tripanossomicida mereceram enfoque abrangente e aprofundado. Também o tratamento de pacientes em risco ou com insuficiência cardíaca, arritmias e eventos tromboembólicos, baseado em recursos farmacológicos e complementares, recebeu especial atenção. Capítulos suplementares subsidiaram as condutas aplicáveis a diversos contextos especiais, entre eles o da co-infecção por T. cruzi/HIV, risco durante cirurgias, em grávidas, na reativação da infecção após transplante cardíacos, e outros.nbsp;nbsp;nbsp;
Por fim, dois capítulos de grande significado social, abordando a estruturação de serviços especializados para atendimento aos indivíduos com a CDC, e revisando os conceitos de cardiopatia grave e suas implicações médico-trabalhistas completaram esta diretriz.nbsp;
6.
Morphological, physiological, and agronomic traits of crossings of 'Icatu' x 'Catimor' coffee tree subjected to water deficit
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Coelho, Larissa Sousa
; Tassone, Guilherme Augusto Teixeira
; Carvalho, Gladyston Rodrigues
; Silva, Vânia Aparecida
; Viana, Mariana Thereza Rodrigues
; Pereira, Fernanda Aparecida Castro
; Nadaleti, Denis Henrique Silva
; Silveira, Helbert Rezende de Oliveira
; Botelho, Cesar Elias
.
Resumo O objetivo deste trabalho foi selecionar genótipos de Coffea arabica com boa produtividade e potencial de tolerância ao deficit hídrico, além de tentar compreender os mecanismos fisiológicos e anatômicos envolvidos na adaptabilidade desses genótipos ao estresse hídrico. Avaliaramse características fisiológicas, anatômicas e agronômicas de 19 genótipos de C. arabica sob as duas seguintes condições hídricas: irrigação regular e sem irrigação (deficit hídrico no solo). Os genótipos 'IPR 100', 2, 5 e 7 apresentaram características agronômicas, fisiológicas e anatômicas que contribuíram para melhor manutenção do estado hídrico no desenvolvimento inicial do cafeeiro. Com base nesses resultados, esses genótipos são potencialmente tolerantes ao deficit hídrico. Os genótipos 4, 10, 11, 14, 15 e 'Bourbon Amarelo IAC J10' apresentam menor adaptabilidade das estruturas anatômicas em condições de deficit hídrico no solo. Os genótipos de cafeeiro apresentam plasticidade foliar, como a espessura do parênquima paliçádico e esponjoso, e o número, posição, dimensões e mobilidade dos estômatos em condições de deficiência hídrica.
Abstract The objective of this work was to select genotypes of Coffea arabica with good yield and potential tolerance to water deficit, as well as to try to understand the physiological and anatomical mechanisms involved in the adaptability of these genotypes to water stress. The physiological, anatomical, and agronomic traits of 19 genotypes of C. arabica were evaluated under the two following water conditions: regular irrigation and no irrigation (soil water deficit). The 'IPR 100', 2, 5, and 7 genotypes showed agronomic, physiological, and anatomical traits that contributed to a better water status maintenance in the initial development of coffee plants. Based on these results, these genotypes are potentially tolerant to water deficit. The 4, 10, 11, 14, 15, and 'Bourbon Amarelo IAC J10' genotypes show a lower adaptability of the anatomical structures under soil-water deficit conditions. The coffee tree genotypes display leaf plasticity, such as the thickness of palisade and spongy parenchyma, and the number, position, dimensions, and mobility of stomata under water deficit conditions.
7.
Does the faxinal system help to maintain the genetic diversity of Curitiba prismatica (D.Legrand) Salywon & Landrum?
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Silva, Richeliel Albert Rodrigues
; Vieira, Fábio de Almeida
; Tambarussi, Evandro Vagner
; Chagas, Kyvia Pontes Teixeira das
; Watzlawick, Luciano Farinha
; Koehler, Henrique Soares
.
ABSTRACT Background: Curitiba prismatica (D.Legrand) Salywon & Landrum belongs to the Myrtaceae family and it is popularly known as murta. Endemic to the Mixed Ombrophilous Forest of south Brazil, is predominant in Faxinal System, which is a traditional agricultural system in the State of Paraná. This species also has several uses and potentials, such as wood for fence posts and essential oils with pharmacological properties. For this reason, this study aimed to select molecular markers and assess whether the Faxinal System contributes to the maintenance of the genetic diversity of the species, helping in its management and conservation. As such, 120 adult reproductive individuals were sampled, 60 in two areas managed in the Faxinal System, and 60 in two conservation areas. Results: Initially, 30 ISSR markers were selected, but only eight showed considerable variability, resulting in 68 polymorphic loci. The results show that the average diversity within populations is 80.54%. The Shannon (I) and Nei’s (He) diversity indices were 0.53 and 0.36, respectively. According to Nei’s genetic identity, the populations form two groups. With the analysis of the genetic structure of the populations, which indicated the existence of two distinct genetic groups (K = 2). Conclusion: Thus, the populations in the Faxinal System had higher rates of genetic diversity, despite constant human activity within the system. Therefore, the Faxinal System contributes to the conservation of C. prismatica genetic diversity; however, considering the economic potential of the species and to minimize impacts on the existing fragments, there is a need to work with the local population to ensure sustainable forest management of the species.
8.
Polymeric micelles containing resveratrol: development, characterization, cytotoxicity on tumor cells and antimicrobial activity
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Almeida, Tamires Cunha
; Seibert, Janaina Brandão
; Almeida, Sávio Henrique de Souza
; Amparo, Tatiane Roquete
; Teixeira, Luiz Fernando de Medeiros
; Barichello, Jose Mario
; Postacchini, Bruna Bueno
; Santos, Orlando David Henrique dos
; Silva, Glenda Nicioli da
.
Antimicrobial and antitumor activities of resveratrol, a compound found mainly in grapes, have already been demonstrated. However, its low bioavailability is a limiting factor for therapeutic application. Polymeric micelles can be an approach to solve this problem since they can encapsulate hydrophobic substances. We developed and characterized micellar formulations containing resveratrol and evaluated their cytotoxic and antimicrobial effects. The formulations were prepared by the cold dispersion method with different concentrations of F127 (5 or 10% w/w) and resveratrol (500 or 5000 µM). The formulations were characterized according to size, polydispersity index, pH, encapsulation rate and in vitro release. Cytotoxic effect was evaluated on a bladder cancer cell line and antimicrobial effect was evaluated on E. coli, S. aureus and C. albicans. One of the formulations (10% w/w of F127 and 5000 µM of resveratrol) was a monodispersed solution with high encapsulation rate, thus it was chosen for the cytotoxicity and antimicrobial assays. MS- 10+RES-3 was able to preserve the antimicrobial and cytotoxic activity of resveratrol. This is the first study that evaluated antimicrobial potential and cytotoxicity of micelles containing resveratrol on bladder cancer cells and the results showed that micellar nanostructures could ensure the maintenance of the biological activity of resveratrol.
https://doi.org/10.1590/s2175-97902019000418401
652 downloads
9.
Elevated High-Sensitivity Troponin I in the Stabilized Phase after an Acute Coronary Syndrome Predicts All-Cause and Cardiovascular Mortality in a Highly Admixed Population: A 7-Year Cohort
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Castro, Leandro Teixeira de
; Santos, Itamar de Souza
; Goulart, Alessandra C.
; Pereira, Alexandre da Costa
; Staniak, Henrique Lane
; Bittencourt, Marcio Sommer
; Lotufo, Paulo Andrade
; Bensenor, Isabela Martins
.
Resumo Fundamento: A troponina cardíaca de alta sensibilidade I (TnI-as) tem desempenhado um papel importante na estratificação de risco dos pacientes durante a fase intra-hospitalar da síndrome coronariana aguda (SCA), mas poucos estudos determinaram seu papel como marcador prognóstico de longo prazo no ambiente ambulatorial. Objetivo: Investigar a associação entre os níveis de TnI-as medidos na fase subaguda após um evento de SCA e o prognóstico a longo prazo, em uma população altamente miscigenada. Métodos: Medimos os níveis de TnI-as em 525 pacientes em um período de 25 a 90 dias após a entrada em hospital por um evento de SCA; esses pacientes foram então divididos em tercis conforme os níveis de TnI-as, e acompanhados por até 7 anos. Comparamos as mortalidades por todas as causas e cardiovascular através de modelos de riscos proporcionais de Cox e adotando um nível de significância de 5%. Resultados: Após um acompanhamento médio de 51 meses, os pacientes no tercil mais alto apresentaram uma taxa de risco (HR) maior para mortalidade por todas as causas, após ajustes para idade, sexo, fatores de risco cardiovascular conhecidos, uso de medicação e fatores demográficos (HR: 3,84 IC 95%: 1,92-8,12). Esses achados persistiram após um ajuste adicional para uma taxa de filtração glomerular (TFG) estimada < 60 ml/min/1,73 m2 e uma fração de ejeção do ventrículo esquerdo < 0,40 (HR: 6,53; IC95%: 2,12-20,14). A mortalidade cardiovascular foi significativamente maior no tercil mais alto, após ajustes para idade e sexo (RR: 5,65; IC95%: 1,94-16,47) e tanto no primeiro modelo de ajuste multivariado (HR: 4,90; IC 95%: 1,35-17,82) quanto no segundo (HR: 5,89; IC95%: 1,08-32,27). Conclusões: Níveis elevados de TnI-as, medidos na fase estabilizada após um evento de SCA, são preditores independentes de mortalidade por todas as causas e de mortalidade cardiovascular em uma população altamente miscigenada.
Abstract Background: High-sensitivity cardiac troponin I (hs-cTnI) has played an important role in the risk stratification of patients during the in-hospital phase of acute coronary syndrome (ACS), but few studies have determined its role as a long-term prognostic marker in the outpatient setting. Objective: To investigate the association between levels of hs-cTnI measured in the subacute phase after an ACS event and long-term prognosis in a highly admixed population. Methods: We measured levels of hs-cTnI in 525 patients 25 to 90 days after admission for an ACS event; these patients were then divided into tertiles according to hs-cTnI levels and followed for up to 7 years. We compared all-cause and cardiovascular mortality using Cox proportional hazards models and adopting a significance level of 5%. Results: After a median follow-up of 51 months, patients in the highest tertile had a greater hazard ratio (HR) for all-cause mortality after adjustment for age, sex, known cardiovascular risk factors, medication use, and demographic factors (HR: 3.84, 95% CI: 1.92-8.12). These findings persisted after further adjustment for estimated glomerular filtration rate < 60 ml/min/1.73 m2 and left ventricular ejection fraction < 0.40 (HR: 6.53, 95% CI: 2.12-20.14). Cardiovascular mortality was significantly higher in the highest tertile after adjustment for age and sex (HR: 5.65, 95% CI: 1.94-16.47) and both in the first (HR: 4.90, 95% CI: 1.35-17.82) and second models of multivariate adjustment (HR: 5.89, 95% CI: 1.08-32.27). Conclusions: Elevated hs-cTnI levels measured in the stabilized phase after an ACS event are independent predictors of all-cause and cardiovascular mortality in a highly admixed population.
https://doi.org/10.5935/abc.20180268
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10.
Portable X-ray fluorescence (pXRF) spectrometry applied to the prediction of chemical attributes in Inceptisols under different land uses
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Teixeira, Anita Fernanda dos Santos
; Weindorf, David C.
; Silva, Sérgio Henrique Godinho
; Guilherme, Luiz Roberto Guimarães
; Curi, Nilton
.
RESUMO Espectrômetria portátil de fluorescência de raios-X (pXRF) tem sido crescentemente adotada para estudos sobre solos. Este trabalho objetivou caracterizar efeitos do manejo do solo no teor de elementos químicos detectados pelo pXRF em Cambissolos manejados e não manejados e avaliar o potencial de uso de dados do pXRF para gerar modelos de predição da fertilidade do solo. Amostras foram coletadas em floresta nativa, Cerrado nativo, cafeeiros com 1 e 5 anos de implantação e eucalipto, nos horizontes A, B e C. Atributos de fertilidade do solo foram determinados por análises laboratoriais, enquanto o teor dos elementos foi obtido pelo pXRF. Dados do pXRF foram utilizados para modelagem (regressões) e validação de atributos de fertilidade do solo, além da necessidade de calagem (NL), com ou sem distinção entre áreas manejadas e não manejadas. Práticas de manejo dos cafeeiros aumentaram os teores totais de Sr, CaO, P2O5, Cu e Zn. Os teores de CaO foram eficientes para predição de teores trocáveis de Ca2+ (R2 = 0,91), pH (R2 = 0,88) e saturação por bases (R2 = 0,89) nas áreas manejadas. Modelos gerais foram adequados para predizer teores trocáveis de Ca2+ (R2 = 0,92), pH (R2 = 0,85) e saturação por bases (R2 = 0,90). Modelos para áreas não manejadas foram menos eficazes. O pXRF detectou modificações no teor dos elementos causadas pelas práticas de manejo e possibilitou predições adequadas de atributos relacionados à fertilidade do solo.
ABSTRACT Portable X-ray fluorescence (pXRF) spectrometry has been increasingly adopted for varying studies worldwide. This work aimed at characterizing effects of soil management on the content of chemical elements detected by pXRF in managed and unmanaged areas of Inceptisols, and evaluating the potential of using pXRF data to generate prediction models for soil fertility attributes, evaluating the effect of land uses on such models. Samples were collected in A, B, and C horizons of soils under native forest, native Cerrado, coffee crops with 1 and 5 years of implantation and eucalyptus. Soil fertility attributes were determined through laboratory analyses, whereas, elemental contents were obtained through pXRF analysis. PXRF data were used for modeling (regressions) and validation of soil fertility attributes and necessity of lime (NL) application, with or without distinction between managed and unmanaged areas. Management practices on coffee crops increased the levels of Sr, CaO, P2O5, Cu, and Zn. CaO content was efficient for prediction of exchangeable Ca2+ contents (R2 = 0.91), pH (R2 = 0.88), base saturation (R2 = 0.89) in managed areas. General models presented adequate results to predict exchangeable Ca2+ (R2 = 0.92), pH (R2 = 0.85), and base saturation (R2 = 0.90). Models for unmanaged areas were less effective. PXRF detected modifications in elemental contents caused by management practices and provided reliable predictions of soil fertility attributes.
https://doi.org/10.1590/1413-70542018425017518
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11.
Molecular diagnosis of diarrheagenic Escherichia coli isolated from Psittaciformes of illegal wildlife trade
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Lopes, Elisângela S.
; Maciel, William C.
; Medeiros, Pedro Henrique Q.S.
; Bona, Mariana D.
; Bindá, Alexandre H.
; Lima, Suzan V.G.
; Gaio, Fernanda C.
; Teixeira, Régis S.C.
.
RESUMO: Escherichia coli diarreiogênicas (DEC) são consideradas uma das causas mais importantes de diarreia em países em desenvolvimento. Alguns estudos têm apontado aves silvestres como importantes reservatórios destes patógenos, entretanto, poucas espécies da ordem Psittaciformes têm sido investigada. O objetivo deste estudo foi analisar a presença de cepas de E. coli diarreiogênicas em Psittaciformes do tráfico de animais silvestres. Um total de 78 amostras de E. coli isoladas de suabes cloacais provenientes de 167 de Psittaciformes do Ceará, Brasil, foram avaliadas quanto a presença dos seguintes genes de virulência DEC por meio de reação em cadeia de polimerase (PCR): eaeA e bfpA (E. coli Enteropatogênica - EPEC); stx1 e stx2 (E. coli produtora de Shiga - STEC); estA e eltB (E. coli Enterotoxigênica - ETEC); ipaH (E. coli Enteroinvasiva - EIEC); aatA e aaiC (E. coli Enteroagregativa - EAEC). As cepas positivas para os genes eaeA e bfpA foram consideradas EPEC típicas, enquanto que as positivas exclusivamente para o gene eaeA foram classificadas como EPEC atípicas. O gene eaeA foi identificado em 20 cepas de E. coli e o gene bfpA em 22 dos isolados. Adicionalmente, 11 e 9 cepas foram classificadas como EPEC típicas e atípicas, respectivamente. Nenhuma cepa foi positiva para os genes stx1 e stx2. Um total de 47 cepas (60,3%) e um total de 136 aves (81,4%) foram negativas para os demais patotipos DEC pesquisados. Em conclusão, psitacídeos provenientes do tráfico de aves silvestres do estado do Ceará, Brasil, apresentaram relevante prevalência de EPEC típicas e atípicas, potencialmente participando como reservatórios de cepas DEC no ambiente. Portanto, medidas de controle devem ser adotadas para inibir a disseminação destes patógenos.
ABSTRACT: Diarrheagenic Escherichia coli (DEC) are considered one of the major causes of human diarrhea in developing countries. Some studies have pointed wild birds as important reservoirs for these pathogens. However, scarce species from the Psittaciformes order have been investigated. This study aimed to evaluate the presence of DEC strains in Psittaciformes from illegal wildlife trade. A total of 78 E. coli strains isolated from cloacal swab samples of 167 Psittaciformes in the Ceará State, Brazil, were evaluated regarding the presence of the following DEC virulence genes by polymerase chain reaction (PCR): eaeA and bfpA genes (Enteropathogenic E. coli - EPEC); stx1 and stx2 (Shiga toxin-producing E. coli - STEC); estA and eltB (Enterotoxigenic E. coli - ETEC); ipaH (Enteroinvasive E. coli - EIEC); aatA and aaiC (Enteroaggregative E. coli - EAEC). Positive strains for eaeA and bfpA genes were considered typical EPEC, while strain positive exclusively for the eaeA gene were classified as atypical EPEC. The eaeA gene was identified in 20 E. coli strains and bfpA in 22 isolates. In addition, 11 and 9 belonged to tEPEC and aEPEC, respectively. No strain was positive for stx1 or stx2. A total of 47 (60.3%) strains and a total of 136 birds (81.4%) were negative for the remaining DEC pathotypes investigated. In conclusion, psittacine from illegal wildlife trade in Ceará State, Brazil, presented a relevant prevalence of typical and atypical EPEC, potentially playing a role as reservoirs of DEC strains in the environment. Thus, proper control measures must be adopted to block the spread of these pathogens.
https://doi.org/10.1590/1678-5150-pvb-5083
1152 downloads
12.
Promoting fruit seedling growth by encapsulated microorganisms
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Santos, Carlos Henrique Barbosa
; Martins, Antonio Baldo Geraldo
; Rigobelo, Everlon Cid
; Teixeira, Gustavo Henrique de Almeida
.
Resumo A utilização de microrganismos capazes de promover o crescimento vegetal tem sido aceita como alternativa à redução do uso de adubos químicos. O objetivo deste trabalho foi avaliar a inoculação de microrganismos promotores do crescimento de plantas em substrato de mudas de espécies frutíferas, verificando a interação do inóculo com agentes encapsulantes: argila e alginato. O inóculo microbiano continha as seguintes espécies: Azospirillum brasilense, Burkolderia cepacia, Bacillus thuringienses, Bacillus megaterium,Bacillus cereus, Bacillus subtilis, Tricodermaspp. e isolado 411. As espécies frutíferas avaliadas foram: Myrciaria cauliflora(DC.) O. Berg (jabuticabeira); Myrciaria glazioviana (Kiaersk.) G. Barros &Sobral (cabeludinha); Myrciaria dubia (Kunth) Mc Vaugh (camu-camu); Eugenia brasiliensis Lam. (grumixama); Diospyros kaki L. (caqui); Garcinia brasiliensis Mart. (bacupari); Annona muricata L. (graviola); Duguetia lanceolata A. St. – Hil. (pindaíba); Chrysophyllum cainito L. (caimito); Anacardium occidentale L. (caju); Eriobotrya japonica (Thunb.) Lindl. (nêspera) e Litchi chinensis Sonn. (lichia). O delineamento experimental foi o inteiramente casualizado (DIC), em esquema fatorial 3 (controle, alginato de sódio e argila) x 2 (presença e ausência de inóculo microbiano), com cinco repetições (uma muda por repetição). As mudas foram mantidas em 50% de iluminação, à temperatura média de 22,5 °C, durante noventa dias, sendo avaliados a altura e o diâmetro do colo das plantas, e a massa seca da parte aérea e das raízes. Micro-organismos promotores de crescimento de plantas, independente do encapsulamento utilizado, promovem desenvolvimento superior de mudas de caimito e de lichia.
Abstract The use of microorganisms capable of promoting plant growth has been accepted as an alternative to reducing the use of chemical fertilizers. The aim of this study was to evaluate the inoculation of plant growth promoting microorganisms in seedlings of fruit species, verifying the interaction of the inoculums with encapsulating agents such as clay and alginate. Microbial inoculums contained the following species: Azospirillum brasilense, Burkolderia cepacia, Bacillus thuringienses, Bacillus megaterium, Bacillus cereus,Bacillus subtilis, Tricoderma spp. and isolate 411. The fruit species evaluated were: Myrciaria cauliflora (DC.) O. Berg; Myrciaria glazioviana (Kiaersk.) G. Barros &Sobral; Myrciaria dubia (Kunth) Mc Vaugh; Eugenia brasiliensis Lam.; Diospyroskaki L.; Garcinia brasiliensis Mart.; Annona muricata L.; Duguetia lanceolata A. St.-Hil.; Chrysophyllum cainito L.; Anacardium occidentale L.; Eriobotrya japonica (Thunb.) Lindl. and Litchi chinensis Sonn. The experimental design was completely randomized, in a factorial scheme 3 (control, sodium alginate and clay) x 2 (presence and absence of microbial inoculum) with five replicates (one seedling per replicate). Seedlings were maintained in 50% of illumination at an average temperature of 22.5 °C for ninety days, and plant height, diameter, root and shoot dry mass were evaluated. Plant growth promoting microorganisms, regardless of encapsulation used, promote higher development of C. cainito and L. chinensis seedlings.
https://doi.org/10.1590/0100-29452018179
1561 downloads
13.
No correlation was observed between vitamin D levels and disability of patients with multiple sclerosis between latitudes 18° and 30° South
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Fragoso, Yara Dadalti
; Adoni, Tarso
; Alves-Leon, Soniza Vieira
; Apostolos-Pereira, Samira L.
; Arruda, Walter Oleschko
; Brooks, Joseph B. Bidin
; Cal, Henrique S. Rodrigues
; Damasceno, Carlos A. Albuquerque
; Gama, Paulo Diniz
; Goncalves, Marcus V. Magno
; Jesus, Carlos A. da Silva de
; Machado, Suzana C. Nunes
; Mansur, Letícia Fezer
; Matta, Andre P. da Cunha
; Mendes, Maria Fernanda
; Morales, Rogerio Rizo
; Nobrega-Jr, Adaucto Wanderley da
; Parolin, Monica K. Fiuza
; Peres, Mario Pietro
; Ribeiro, Marlise de Castro
; Ruocco, Heloisa Helena
; Scherpenhuijzen, Simone
; Siquinelli, Fabio
; Stoney, Patrick N.
; Varela, Daniel Lima
; Eboni, Audred Cristina Biondo
; Spessotto, Caroline Vieira
; Rocha, Elisa Teixeira da
; Lacerda, Pamela Emanuele
.
RESUMO Objetivo: Vitamina D assumiu um papel central na pesquisa e tratamento da esclerose múltipla (EM). O objetivo deste estudo foi avaliar os níveis séricos de vitamina D de pacientes com EM e controles que residem em uma área tropical. Métodos: Foram analisados dados de 535 pacientes com EM e 350 indivíduos controle em 14 cidades próximas ao Trópico de Capricórnio. Resultados: O valor médio da determinação de 25-OH vitamina D foi 26,07 ± 10,27 ng/mL para controles e 28,03 ± 12,19 ng/mL para pacientes com EM. Não houve correlação entre os níveis de vitamina D e o grau de incapacidade ao longo da duração da doença. Conclusão: Pelo menos na região que cerca o Trópico de Capricórnio, os níveis séricos de vitamina D estão entre valores de 20 a 30 ng/mL tanto para controles quanto para pacientes com EM.
ABSTRACT Objective: Vitamin D has taken center stage in research and treatment of multiple sclerosis (MS). The objective of the present study was to assess the serum vitamin D levels of a large population of patients with MS and controls living in a restricted tropical area. Methods: Data from 535 patients with MS and 350 control subjects were obtained from 14 cities around the Tropic of Capricorn. Results: The mean serum 25-OH vitamin D level was 26.07 ± 10.27 ng/mL for the control subjects, and 28.03 ± 12.19 ng/mL for patients with MS. No correlation was observed between vitamin D levels and the disability of patients over the disease duration. Conclusion: At least for the region around the Tropic of Capricorn, serum levels of vitamin D typically are within the range of 20 to 30 ng/mL for controls and patients with MS.
https://doi.org/10.1590/0004-282x20160173
3011 downloads
14.
Genetic predisposition to higher production of interleukin-6 through -174 G > C polymorphism predicts global cognitive decline in oldest-old with cognitive impairment no dementia
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Fraga, Vanessa G.
; Guimarães, Henrique C.
; Teixeira, Antônio L.
; Barbosa, Maira T.
; Mateo, Elvis C. C.
; Carvalho, Maria G.
; Caramelli, Paulo
; Gomes, Karina B.
.
Interleucina 6 (IL-6) é uma citocina pró-inflamatória cuja produção acentua-se em contextos neurodegenerativos. O polimorfismo IL-6 -174 G > C influencia os níveis secretados deste mediador inflamatório. Nós objetivamos avaliar a influência de IL-6 -174 G > C sobre o escore cognitivo global de um grupo com comprometimento cognitivo não demência em um ano de seguimento.Métodos Os participantes foram categorizados em dois grupos: com declínio em escore cognitivo global em curto prazo e aqueles com melhora ou estabilidade do escore cognitivo global.Resultados Nós observamos que indivíduos com comprometimento cognitivo não demência carreadores do genótipo GGbaixa foram mais frequentes entre pacientes com escore cognitivo global não declinante, enquanto carreadores de no mínimo um alelo Caltaforam mais frequentes no grupo que apresentou declínio no escore cognitivo global (p = 0,012; RR = 3,095 IC95%= 1,087-8,812).Conclusão Estes resultados sugerem que a alta expressão do gene IL-6 pode ser um fator de risco independente para declínio cognitivo entre pacientes com comprometimento cognitivo não demência.
Interleukin 6 (IL-6) is a pro-inflammatory cytokine upregulated in neurodegenerative contexts. The polymorphism IL-6 -174 G > C influences release levels of this cytokine. We aimed to evaluate the influence of IL-6 -174 G > C on global cognitive score of a group with cognitive impairment no dementia in one year of follow-up.Methods The subjects were categorized in two groups: short-term decline in global cognitive score and those with short-term stability or improvement. IL-6 174 G > C information were compared among these groups.Results We observed that individuals with cognitive impairment no dementia with GGlowergenotype were more frequent among global cognitive score non-decliners while carriers of at least one Chigherallele were more frequent in the group with global cognitive score decliners (p = 0.012; RR = 3.095 IC95%= 1.087-8.812).Conclusion These results suggest that the higher expression of IL-6 gene may be an independent risk factor for cognitive decline among individuals with cognitive impairment no dementia.
https://doi.org/10.1590/0004-282X20150137
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15.
A new Amphisbaena (Squamata: Amphisbaenidae) from southern Espinhaço Range, southeastern Brazil
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Costa, Henrique C.
; Resende, Flávia C.
; Teixeira Jr., Mauro
; Vechio, Francisco Dal
; Clemente, Cinara A.
.
Uma nova espécie de Amphisbaena é descrita de uma floresta semidecidual em Conceição do Mato Dentro, sul da Cadeia do Espinhaço, Minas Gerais, Brasil. A seguinte combinação de caracteres permite diagnosticar a nova espécie das demais congêneres: cabeça arredondada; dois ou três poros pré-cloacais dispostos em sequência; 190-199 annuli corporais; 2-3 annuli laterais; 23-25 annuli caudais; plano de autotomia nos annuli caudais 7-9; 12-14 segmentos dorsais no annulus do meio do corpo; 14-16 segmentos ventrais no annulus do meio do corpo; três supralabiais; três infralabiais; fileira pós-malar presente ou ausente; dorso marrom-claro, com suturas intersegmentares creme; ventre creme. Até o momento a nova espécie é conhecida apenas para a Cadeia do Espinhaço, ressaltando a importância de ações de conservação para essas montanhas.
A new species of Amphisbaena is described from a semi-deciduous forest in Conceição do Mato Dentro, southern Espinhaço Range, Minas Gerais, Brazil. The following combined characters can diagnose the new species from all congeners: head round-shaped; two or three precloacal pores sequentially arranged; 190-199 body annuli; 2-3 lateral annuli; 23-25 caudal annuli; autotomy sites on caudal annuli 7-9; 12-14 dorsal segments on midbody annulus; 14-16 ventral segments on midbody annulus; three supralabials; three infralabials; postmalar row present or absent; dorsum light brown, with cream intersegmental sutures; venter cream. To date, the new species is known only from the Espinhaço Range, highlighting the importance of conservation actions for these mountains.
https://doi.org/10.1590/0001-3765201520140088
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