Abstract This article aims to estimate the underreporting of violence against women (VAW) in the Notifiable Diseases Information System (SINAN), based on data from the National Survey of Health (NSH), in Brazil and subnational units (SU). This work was an ecological study using SINAN and NSH, both from 2019. In SINAN, reports of sexual, physical, and psychological VAW, aged 18 years or older, were selected. In the NSH, women of the same age group who reported psychological, physical, or sexual violence, and who had sought health care due to consequences of the violence were selected. SINAN underreporting was calculated in reference to the NSH’s estimated population, for Brazil and each SU. Underreporting of VAW in Brazil was 98.5%, 75.9%, and 89.4% for psychological, physical, and sexual violence, respectively. The North and Northeast states presented the lowest reporting rates among the states. VAW in Brazil is highly underreported by the health sector, showing the need for adequate training of health professionals to recognize situations of violence and raise awareness of the importance of reporting.

Resumo O objetivo do artigo é estimar a subnotificação da violência contra as mulheres (VCM) no Sistema de Informação de Agravos de Notificação (SINAN) a partir de dados da Pesquisa Nacional de Saúde (PNS), para o Brasil e as unidades federadas (UF). Estudo ecológico utilizando o SINAN e a PNS, ambos do ano de 2019. No SINAN, foram selecionadas as notificações de casos de violências sexual, física e psicológica contra mulheres com idade igual ou superior a 18 anos. Na PNS, foram selecionadas as mulheres da mesma faixa etária com relato de violência psicológica, física ou sexual que tenham procurado atendimento em saúde em razão de consequência relacionada à violência vivida. Calculou-se a subnotificação do SINAN a partir da estimativa da população da PNS para o Brasil e cada UF. A subnotificação de VCM no Brasil foi de 98,5%, 75,9% e 89,4% para as violências psicológica, física e sexual, respectivamente. Os estados do Norte e Nordeste apresentaram os menores índices de notificação entre as UF. A VCM no Brasil apresenta grande subnotificação no setor saúde, demonstrando a necessidade de capacitação dos profissionais de saúde para o reconhecimento de situações de violência e conscientização da importância da notificação.

Abstract This article aims to estimate the underreporting of violence against women (VAW) in the Notifiable Diseases Information System (SINAN), based on data from the National Survey of Health (NSH), in Brazil and subnational units (SU). This work was an ecological study using SINAN and NSH, both from 2019. In SINAN, reports of sexual, physical, and psychological VAW, aged 18 years or older, were selected. In the NSH, women of the same age group who reported psychological, physical, or sexual violence, and who had sought health care due to consequences of the violence were selected. SINAN underreporting was calculated in reference to the NSH’s estimated population, for Brazil and each SU. Underreporting of VAW in Brazil was 98.5%, 75.9%, and 89.4% for psychological, physical, and sexual violence, respectively. The North and Northeast states presented the lowest reporting rates among the states. VAW in Brazil is highly underreported by the health sector, showing the need for adequate training of health professionals to recognize situations of violence and raise awareness of the importance of reporting. (VAW , (SINAN) NSH (NSH) SU . (SU) 2019 physical 1 older selected NSHs s population 985 98 5 98.5% 759 75 9 75.9% 894 89 4 89.4 respectively sector (SINAN (NSH (SU 201 98.5 7 75.9 8 89. 20 98. 75. 2

Resumo O objetivo do artigo é estimar a subnotificação da violência contra as mulheres (VCM) no Sistema de Informação de Agravos de Notificação (SINAN) a partir de dados da Pesquisa Nacional de Saúde (PNS), para o Brasil e as unidades federadas (UF). Estudo ecológico utilizando o SINAN e a PNS, ambos do ano de 2019. No SINAN, foram selecionadas as notificações de casos de violências sexual, física e psicológica contra mulheres com idade igual ou superior a 18 anos. Na PNS, foram selecionadas as mulheres da mesma faixa etária com relato de violência psicológica, física ou sexual que tenham procurado atendimento em saúde em razão de consequência relacionada à violência vivida. Calculou-se a subnotificação do SINAN a partir da estimativa da população da PNS para o Brasil e cada UF. A subnotificação de VCM no Brasil foi de 98,5%, 75,9% e 89,4% para as violências psicológica, física e sexual, respectivamente. Os estados do Norte e Nordeste apresentaram os menores índices de notificação entre as UF. A VCM no Brasil apresenta grande subnotificação no setor saúde, demonstrando a necessidade de capacitação dos profissionais de saúde para o reconhecimento de situações de violência e conscientização da importância da notificação. (VCM (SINAN , (PNS) UF . (UF) 2019 1 anos vivida Calculouse Calculou se 985 98 5 98,5% 759 75 9 75,9 894 89 4 89,4 respectivamente (PNS (UF 201 98,5 7 75, 8 89, 20 98, 2

Abstract: Undergraduate students are often impacted by depression, anxiety, and stress. In this context, machine learning may support mental health assessment. Based on the following research question: “How do machine learning models perform in the detection of depression, anxiety, and stress among undergraduate students?”, we aimed to evaluate the performance of these models. PubMed, Embase, PsycINFO, and Web of Science databases were searched, aiming at studies meeting the following criteria: publication in English; targeting undergraduate university students; empirical studies; having been published in a scientific journal; and predicting anxiety, depression, or stress outcomes via machine learning. The certainty of evidence was analyzed using the GRADE. As of January 2024, 2,304 articles were found, and 48 studies met the inclusion criteria. Different types of data were identified, including behavioral, physiological, internet usage, neurocerebral, blood markers, mixed data, as well as demographic and mobility data. Among the 33 studies that provided accuracy assessment, 30 reported values that exceeded 70%. Accuracy in detecting stress ranged from 63% to 100%, anxiety from 53.69% to 97.9%, and depression from 73.5% to 99.1%. Although most models present adequate performance, it should be noted that 47 of them only performed internal validation, which may overstate the performance data. Moreover, the GRADE checklist suggested that the quality of the evidence was very low. These findings indicate that machine learning algorithms hold promise in Public Health; however, it is crucial to scrutinize their practical applicability. Further studies should invest mainly in external validation of the machine learning models.

Resumen: Los estudiantes de grado suelen verse afectados por la depresión, la ansiedad y el estrés. El aprendizaje automático puede respaldar la evaluación de la salud mental. Con base en la siguiente pregunta de investigación “¿Cuál es el rendimiento de los modelos de aprendizaje automático en la detección de depresión, ansiedad y estrés entre estudiantes universitarios?”, nuestro objetivo fue evaluar el rendimiento de estos modelos. Se realizaron búsquedas en PubMed, Embase, PsycINFO y Web of Science. Se buscaron estudios que cumplieran con los siguientes criterios: se hubieran publicado en inglés, tuvieran a estudiantes universitarios como población objetivo, fueran empíricos, publicados en una revista científica y que predijeran resultados de ansiedad, depresión o estrés mediante aprendizaje automático. La calidad de las evidencias se analizó mediante GRADE. En enero del 2024 se encontraron 2.304 artículos, y 48 estudios cumplieron con los criterios de inclusión. Se identificaron diferentes tipos de datos, incluidos datos conductuales, fisiológicos, de uso de internet, neurocerebrales, marcadores sanguíneos, datos mixtos, demográficos y de movilidad. Entre los 33 estudios que proporcionaron datos de precisión, 30 reportaron valores superiores al 70%. La precisión en la detección del estrés osciló entre el 63% y el 100%, la ansiedad del 53,69% al 97,9% y la depresión del 73,5% al 99,1%. Aunque la mayoría de los modelos presenta un rendimiento adecuado, cabe señalar que 47 de ellos realizaron únicamente validación interna, lo que puede sobrestimar los datos de rendimiento. Además, la evaluación GRADE indicó que la calidad de la evidencia es muy baja. Los resultados indican que los algoritmos de aprendizaje automático son prometedores en el campo de la Salud Pública; sin embargo, es crucial examinar su aplicabilidad práctica. Los estudios futuros deberían invertir principalmente en la validación externa de los modelos de aprendizaje automático.

Resumo: Os alunos de graduação são frequentemente afetados por depressão, ansiedade e estresse. O aprendizado de máquina pode apoiar a avaliação da saúde mental. Com base na seguinte questão de pesquisa “Qual é o desempenho dos modelos de aprendizado de máquina na detecção de depressão, ansiedade e estresse entre estudantes de graduação?”, objetivou-se avaliar o desempenho desses modelos. As pesquisas foram realizadas no PubMed, Embase, PsycINFO e Web of Science. Foram pesquisados estudos que atendessem aos seguintes critérios: publicados em inglês, estudantes universitários de graduação como população alvo, empíricos, publicados em uma revista científica e que previssem resultados de ansiedade, depressão ou estresse via aprendizado de máquina. A qualidade das evidências foi analisada usando o GRADE. Em janeiro de 2024, foram encontrados 2.304 artigos, e 48 estudos atenderam aos critérios de inclusão. Foram identificados diferentes tipos de dados, incluindo dados comportamentais, fisiológicos, de uso da Internet, neurocerebrais, marcadores sanguíneos, dados mistos, demográficos e de mobilidade. Entre os 33 estudos que forneceram dados de precisão, 30 relataram valores superiores a 70%. A acurácia na detecção de estresse variou de 63% a 100%, ansiedade de 53,69% a 97,9% e depressão de 73,5% a 99,1%. Embora a maioria dos modelos apresente desempenho adequado, deve-se notar que 47 deles realizaram apenas validação interna, o que pode superestimar os dados de desempenho. Além disso, a avaliação GRADE indicou que a qualidade da evidência é muito baixa. Os resultados indicam que os algoritmos de aprendizado de máquina são promissores no campo da Saúde Pública; no entanto, é crucial examinar sua aplicabilidade prática. Estudos futuros devem investir principalmente na validação externa dos modelos de aprendizado de máquina.

ABSTRACT The diagnostic criteria for gestational diabetes mellitus (GDM), a transient hyperglycemic state during pregnancy, has varied remarkably over time, resulting in a diversity of prevalence rates. The aim of this systematic literature review was to provide estimates of prevalence rates of GDM in Brazil according to different diagnostic criteria. We identified, reviewed, and extracted data from the scientific literature on studies estimating the prevalence of diabetes in pregnant women living in Brazil. The databases searched were PubMed, LILACS, SciELO, Embase, Web of Science, and Cochrane Library. We grouped studies by the source of information assessing GDM, patients’ age, and criteria used to diagnose GDM. When three or more studies were available in a group, we calculated the pooled prevalence. The Joanna Briggs Institute (JBI) appraisal tool was used to assess the risk of bias. The data were reported according to the 2020 PRISMA recommendations. The study protocol was registered in PROSPERO. We identified 1,328 records and selected 21 studies involving 122,635 pregnant women. Studies in adults only, with primary data and laboratory measurements, and using the IADPSG criteria (n = 3) had a GDM prevalence of 18.0% (95% confidence interval [CI]: 16.0-20.1%) and included 6,243 participants. Estimates of self-reported GDM (n = 3; 10,136 participants of all ages) had a pooled GDM prevalence of 2.1% (95% CI: 1.5-5.2%), with high heterogeneity (I2 = 85.0%, p < 0.01). Studies including adolescents had consistently low prevalences. The prevalence of GDM in Brazil varied, was greater when the IADPSG criteria were applied, and depended on the methods used to obtain the GDM information and the age structure of the sample. , (GDM) pregnancy time reviewed PubMed LILACS SciELO Embase Science Library patients group JBI (JBI bias 202 recommendations PROSPERO 1328 1 328 1,32 2 122635 122 635 122,63 only measurements n 3 180 18 0 18.0 95% 95 (95 CI [CI] 16.020.1% 160201 16.0 20.1% 16 20 16.0-20.1% 6243 6 243 6,24 selfreported self 10136 10 136 10,13 ages 2.1 1.55.2%, 1552 1.5 5.2% 5 1.5-5.2%) I2 I (I 850 85 85.0% 0.01. 001 0.01 . 01 0.01) prevalences applied sample (GDM 132 32 1,3 12263 12 63 122,6 18. 9 (9 [CI 020 16.020.1 16020 160 16. 201 20.1 16.0-20.1 624 24 6,2 1013 13 10,1 2. 55 1.55.2% 155 15 1. 52 5.2 1.5-5.2% 8 85.0 00 0.0 1, 1226 122, ( 02 16.020. 1602 20. 16.0-20. 62 6, 101 10, 1.55.2 5. 1.5-5.2 85. 0. 16.020 16.0-20 1.55. 1.5-5. 16.02 16.0-2 1.55 1.5-5 16.0- 1.5-

Abstract Objective: Changes in the epidemiology of respiratory infections during the restrictions imposed as a response to the coronavirus disease 2019 (COVID-19) pandemic have been reported elsewhere. The present study’s aim was to describe the prevalence of a large array of respiratory pathogens in symptomatic children and adolescents during the pandemic in Southern Brazil. Methods: Hospitalized and outpatients aged 2 months to 18 years with signs and symptoms of acute COVID-19 were prospectively enrolled in the study from May to November 2020 in two hospitals in a large metropolitan area in a Brazilian city. All participants performed a real-time PCR panel assessing 20 respiratory pathogens (three bacteria and 17 viruses). Results: 436 participants were included, with 45 of these hospitalized. Rhinovirus was the most prevalent pathogen (216/436) followed by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, 97/436), with a coinfection of these two viruses occurring in 31/436 participants. The remaining pathogens were found in 24 symptomatic participants (adenovirus, n = 6; Chlamydophila pneumoniae, n = 1; coronavirus NL63, n = 2; human enterovirus, n = 7; human metapneu-movirus, n = 2; Mycoplasma pneumoniae, n = 6). Hospitalization was more common among infants (p = 0.004) and those with pathogens other than SARS-CoV-2 (p = 0.001). Conclusion: During the period of social distancing in response to COVID-19, the prevalence of most respiratory pathogens was unusually low. Rhinovirus remained as the main virus co-circulating with SARS-CoV-2. COVID-19 in symptomatic children was less associated with hospitalization than with other respiratory infections in children and adolescents.

ABSTRACT Objective: To evaluate the association between obesity and hospitalization in mild COVID-19 adult outpatients in Brazil. Subjects and methods: Adults with signs and symptoms suggestive of acute SARS-CoV-2 infection who sought treatment in two hospital (public and private) emergency departments were prospectively enrolled. Patients with confirmed COVID-19 at inclusion were followed by phone calls at days D7, D14 and D28. Multivariable logistic regression models were employed to explore the association between obesity and other potential predictors for hospitalization. Results: A total of 1,050 participants were screened, and 297 completed the 28-day follow-up and were diagnosed with COVID-19 by RT-PCR. The median age was 37.2 (IQR 29.7-44.6) years, and 179 (60.0%) were female. The duration of symptoms was 3.0 (IQR 2.0-5.0) days, and 10.0 (IQR 8.0-12.0) was the median number of symptoms at inclusion. Ninety-five (32.0%) individuals had obesity, and 233 (78.5%) had no previous medical conditions. Twenty-three participants (7.7%) required hospitalization during the follow-up period. After adjusting, obesity (BMI ≥ 30.0 kg/m2) (OR = 2.69, 95% CI 1.63-4.83, P < 0.001) and older age (OR = 1.05, 95% CI 1.01-1.09, P < 0.001) were significantly associated with higher risks of hospitalization. Conclusion: Obesity, followed by aging, was the main factor associated with hospital admission for COVID-19 in a young population in a low-middle income country. Our findings highlighted the need to promote additional protection for individuals with obesity, such as vaccination, and to encourage lifestyle changes.

Abstract Objective: to evaluate the accuracy of an antibody point-of-care lateral flow immunoassay (LFI -Wondfo Biotech Co., Guangzhou, China) in a pediatric population. Methods: children and adolescents (2 months to 18 years) with signs and symptoms suggestive of acute SARS-CoV-2 infection were prospectively investigated with nasopharyngeal RT-PCR and LFI at the emergency room. RT-PCR was performed at baseline, and LFI at the same time or scheduled for those with less than 7 days of the clinical picture. Overall accuracy, sensitivity and specificity were assessed, as well as according to the onset of symptoms (7-13 or ≥14 days) at the time of the LFI test. Results: In 175 children included, RT-PCR and LFI were positive in 51 (29.14%) and 36 (20.57%), respectively. The overall sensitivity, specificity, positive and negative predictive value was 70.6% (95%CI 56.2-82.5), 96.8% (95%CI 91.9-99.1), 90.0% (95%CI 77.2-96.0), and 88.9% (95%CI 83.9-92.5), respectively. At 7-13 and ≥14 days after the onset of symptoms, sensitivity was 60.0% (95%CI 26.2-87.8) and 73.2% (95%CI 57.1-85.8) and specificity was 97.9% (95%CI 88.7-99.9) and 96.1% (95%CI 89.0-99.2), respectively. Conclusion: Despite its high specificity, in the present study the sensitivity of LFI in children was lower (around 70%) than most reports in adults. Although a positive result is informative, a negative LFI test cannot rule out COVID-19 in children.

Os testes sorológicos no local de atendimento (point-of-care) para a infecção pelo SARS-CoV-2 têm sidos utilizados para o diagnóstico da COVID-19. Entretanto, não está plenamente elucidada a acurácia dos testes ao longo do tempo em relação ao início dos sintomas. Nosso objetivo foi de avaliar a acurácia, no local de atendimento, do imunoensaio de fluxo lateral (LFI). Pacientes com ≥ 18 anos de idade que apresentavam sintomas clínicos sugestivos de infecção aguda pelo SARS-CoV-2 foram testados uma vez com RT-PCR da nasofaringe e orofaringe, além do LFI. A acurácia do LFI foi avaliada com intervalos periódicos de 3 dias a partir do início dos sintomas. O ponto de corte ótimo foi definido como o número necessário de dias para atingir a melhor sensibilidade e especificidade. Esse ponto foi utilizado também para comparar a acurácia do LFI de acordo com a situação do paciente (ambulatorial ou hospitalizado). Foram incluídos 959 pacientes, dos quais 379 (39,52%) testaram positivos para SARS-CoV-2 pelo RT-PCR e 272 (28,36%) pelo LFI. Foi atingido o melhor desempenho para o LFI com 10 dias a partir do início dos sintomas, com sensibilidade e especificidade de 84,9% (IC95%: 79,8-89,1) e 94,4% (IC95%: 91,0-96,8), respectivamente. Embora a especificidade não tenha sido diferente entre os grupos de pacientes (94,6% vs. 88,9%, p = 0,051), a sensibilidade foi mais alta nos pacientes hospitalizados que nos ambulatoriais (91,7% vs. 82,1%, p = 0,032) no dia 10 depois do início dos sintomas. A melhor sensibilidade do LFI no local de atendimento ocorre 10 dias depois do início dos sintomas, o que pode limitar seu uso no atendimento agudo. A especificidade permanece alta, independentemente do número de dias desde o início dos sintomas.

Point-of-care serological tests for SARS-CoV-2 have been used for COVID-19 diagnosis. However, their accuracy over time regarding the onset of symptoms is not fully understood. We aimed to assess the accuracy of a point-of-care lateral flow immunoassay (LFI). Subjects, aged over 18 years, presenting clinical symptoms suggestive of acute SARS-CoV-2 infection were tested once by both nasopharyngeal and oropharyngeal RT-PCR and LFI. The accuracy of LFI was assessed in periodic intervals of three days in relation to the onset of symptoms. The optimal cut-off point was defined as the number of days required to achieve the best sensitivity and specificity. This cut-off point was also used to compare LFI accuracy according to participants’ status: outpatient or hospitalized. In total, 959 patients were included, 379 (39.52%) tested positive for SARS-CoV-2 with RT-PCR, and 272 (28.36%) tested positive with LFI. LFI best performance was achieved after 10 days of the onset of symptoms, with sensitivity and specificity of 84.9% (95%CI: 79.8-89.1) and 94.4% (95%CI: 91.0-96.8), respectively. Although the specificity was similar (94.6% vs. 88.9%, p = 0.051), the sensitivity was higher in hospitalized patients than in outpatients (91.7% vs. 82.1%, p = 0.032) after 10 days of the onset of symptoms. Best sensitivity of point-of-care LFI was found 10 days after the onset of symptoms which may limit its use in acute care. Specificity remained high regardless of the number of days since the onset of symptoms.

Los puestos de atención para pruebas serológicas del SARS-CoV-2 han sido usado para la diagnosis de la COVID-19. No obstante, su precisión a lo largo del tiempo, en lo que respecta a la aparición de los síntomas, no se ha comprendido completamente. Nuestro objetivo fue evaluar la precisión de un puesto de atención de inmunoanálisis de flujo lateral (LFI). Se hizo pruebas a individuos ≥ 18 años, presentando síntomas clínicos compatibles con una infección aguda de SARS-CoV-2, tanto vía nasofaríngea y orofaríngea RT-PCR, como LFI. La precisión de LFI fue evaluada en intervalos periódicos de 3 días con respecto a la aparición de los síntomas. El punto óptimo de corte se definió como el número de días requerido para alcanzar la mejor sensibilidad y especificidad. Este punto también se usó para comparar la precisión del LFI, según el estatus de los participantes: ambulatorios u hospitalizados. Se incluyeron a 959 pacientes, 379 (39,52%) dieron positivo en las pruebas de SARS-CoV-2 RT-PCR, y 272 (28,36%) fueron positivos en los LFI. Se alcanzó el mejor rendimiento de los LFI tras 10 días de la aparición de los síntomas, con una sensibilidad y especificidad de un 84,9% (IC95%: 79,8-89,1) y 94,4% (IC95%: 91,0-96,8), respectivamente. A pesar de que la especificidad no fue diferente (94,6% vs. 88,9%, p = 0,051), la sensibilidad fue mayor en pacientes hospitalizados que en los ambulatorios (91,7% vs. 82,1%, p = 0,032) tras 10 días desde la aparición de los síntomas. La mejor sensibilidad LFI del puesto de cuidado se produce tras 10 días de la aparición de los síntomas, lo que quizás limite su uso en el cuidado de urgencias. La especificidad permanece alta independientemente del número de días desde la aparición de los síntomas.

Os testes sorológicos no local de atendimento (point-of-care) para a infecção pelo SARS-CoV-2 têm sidos utilizados para o diagnóstico da COVID-19. Entretanto, não está plenamente elucidada a acurácia dos testes ao longo do tempo em relação ao início dos sintomas. Nosso objetivo foi de avaliar a acurácia, no local de atendimento, do imunoensaio de fluxo lateral (LFI). Pacientes com ≥ 18 anos de idade que apresentavam sintomas clínicos sugestivos de infecção aguda pelo SARS-CoV-2 foram testados uma vez com RT-PCR da nasofaringe e orofaringe, além do LFI. A acurácia do LFI foi avaliada com intervalos periódicos de 3 dias a partir do início dos sintomas. O ponto de corte ótimo foi definido como o número necessário de dias para atingir a melhor sensibilidade e especificidade. Esse ponto foi utilizado também para comparar a acurácia do LFI de acordo com a situação do paciente (ambulatorial ou hospitalizado). Foram incluídos 959 pacientes, dos quais 379 (39,52%) testaram positivos para SARS-CoV-2 pelo RT-PCR e 272 (28,36%) pelo LFI. Foi atingido o melhor desempenho para o LFI com 10 dias a partir do início dos sintomas, com sensibilidade e especificidade de 84,9% (IC95%: 79,8-89,1) e 94,4% (IC95%: 91,0-96,8), respectivamente. Embora a especificidade não tenha sido diferente entre os grupos de pacientes (94,6% vs. 88,9%, p = 0,051), a sensibilidade foi mais alta nos pacientes hospitalizados que nos ambulatoriais (91,7% vs. 82,1%, p = 0,032) no dia 10 depois do início dos sintomas. A melhor sensibilidade do LFI no local de atendimento ocorre 10 dias depois do início dos sintomas, o que pode limitar seu uso no atendimento agudo. A especificidade permanece alta, independentemente do número de dias desde o início dos sintomas.

Point-of-care serological tests for SARS-CoV-2 have been used for COVID-19 diagnosis. However, their accuracy over time regarding the onset of symptoms is not fully understood. We aimed to assess the accuracy of a point-of-care lateral flow immunoassay (LFI). Subjects, aged over 18 years, presenting clinical symptoms suggestive of acute SARS-CoV-2 infection were tested once by both nasopharyngeal and oropharyngeal RT-PCR and LFI. The accuracy of LFI was assessed in periodic intervals of three days in relation to the onset of symptoms. The optimal cut-off point was defined as the number of days required to achieve the best sensitivity and specificity. This cut-off point was also used to compare LFI accuracy according to participants’ status: outpatient or hospitalized. In total, 959 patients were included, 379 (39.52%) tested positive for SARS-CoV-2 with RT-PCR, and 272 (28.36%) tested positive with LFI. LFI best performance was achieved after 10 days of the onset of symptoms, with sensitivity and specificity of 84.9% (95%CI: 79.8-89.1) and 94.4% (95%CI: 91.0-96.8), respectively. Although the specificity was similar (94.6% vs. 88.9%, p = 0.051), the sensitivity was higher in hospitalized patients than in outpatients (91.7% vs. 82.1%, p = 0.032) after 10 days of the onset of symptoms. Best sensitivity of point-of-care LFI was found 10 days after the onset of symptoms which may limit its use in acute care. Specificity remained high regardless of the number of days since the onset of symptoms.

Los puestos de atención para pruebas serológicas del SARS-CoV-2 han sido usado para la diagnosis de la COVID-19. No obstante, su precisión a lo largo del tiempo, en lo que respecta a la aparición de los síntomas, no se ha comprendido completamente. Nuestro objetivo fue evaluar la precisión de un puesto de atención de inmunoanálisis de flujo lateral (LFI). Se hizo pruebas a individuos ≥ 18 años, presentando síntomas clínicos compatibles con una infección aguda de SARS-CoV-2, tanto vía nasofaríngea y orofaríngea RT-PCR, como LFI. La precisión de LFI fue evaluada en intervalos periódicos de 3 días con respecto a la aparición de los síntomas. El punto óptimo de corte se definió como el número de días requerido para alcanzar la mejor sensibilidad y especificidad. Este punto también se usó para comparar la precisión del LFI, según el estatus de los participantes: ambulatorios u hospitalizados. Se incluyeron a 959 pacientes, 379 (39,52%) dieron positivo en las pruebas de SARS-CoV-2 RT-PCR, y 272 (28,36%) fueron positivos en los LFI. Se alcanzó el mejor rendimiento de los LFI tras 10 días de la aparición de los síntomas, con una sensibilidad y especificidad de un 84,9% (IC95%: 79,8-89,1) y 94,4% (IC95%: 91,0-96,8), respectivamente. A pesar de que la especificidad no fue diferente (94,6% vs. 88,9%, p = 0,051), la sensibilidad fue mayor en pacientes hospitalizados que en los ambulatorios (91,7% vs. 82,1%, p = 0,032) tras 10 días desde la aparición de los síntomas. La mejor sensibilidad LFI del puesto de cuidado se produce tras 10 días de la aparición de los síntomas, lo que quizás limite su uso en el cuidado de urgencias. La especificidad permanece alta independientemente del número de días desde la aparición de los síntomas.

Abstract INTRODUCTION: The goal of reducing the burden of non-communicable diseases (NCDs) requires close monitoring. Our objective is to characterize the decline of premature NCD mortality in Brazil based on Global Burden of Diseases (GBD) Study 2019 estimates. METHODS: We used GBD 2019 data to estimate death rates of the four main NCDs - cardiovascular diseases, neoplasms, diabetes, and chronic respiratory diseases. We estimated the unconditional probability of death between ages 30 to 69, as recommended by the World Health Organization, as well as premature crude- and age-standardized death rates and disability-adjusted life years (DALYs) lost for these conditions. We also estimated trends in suicide (self-harm) death rates. RESULTS: From 2010 to 2019, the age-standardized unconditional probability of premature death declined -1.4%/year (UI: -1.7%;-1.0%) . Age-standardized death rates declined -1.5%/year (UI: -1.9%; -1.2%), and crude death rates -0.6%/year (UI: (-1.0%; -0.2%). Level of development correlated strongly with the rate of decline, with greatest declines occurring in the Southeast, Center West and South regions. Age-standardized mortality from self-harm declined, most notably in the elderly. CONCLUSIONS: Premature mortality due to the main NCDs has declined from 1990 in Brazil, although at a diminishing rate over time. The unconditional probability of death and the age-standardized mortality rate produced similar estimates of decline for the four main NCDs, and mirror well decline in mortality from all NCDs. Declines, especially more recent ones, fall short of the international goals. Strategic public health actions are needed. The challenge to implement them will be great, considering the political and economic instability currently faced by Brazil.

Abstract INTRODUCTION: Non-Communicable Diseases (NCDs) have become the main cause of disease burden in Brazil. Our objective was to describe trends (1990 to 2019) in prevalence and attributable burden of five modifiable risk factors and related metabolic risk factors in Brazil and its states. METHODS: In Global Burden of Disease 2019 analyses, we described trends in prevalence of modifiable risk factors and their metabolic mediators as percentage change in Summary Exposure Value (SEV). We estimated deaths and disability-adjusted life years (DALYs) attributable to the risk factors. RESULTS: Age-adjusted exposures to alcohol [41.0%, Uncertainty Interval (UI): 24.2 - 63.4], red meat (61.2%, UI: 42.4-92.3), low physical activity (3.9%, UI: -5-17.5) and ambient particulate matter pollution (3.3%, UI: -48.9-128.0) have worsened. Those for smoking (-51.4%, UI: -54.7- - 47.8), diet low in fruits (-28.1%, UI: -39.1- -18.7) and vegetables (-19.6%, UI: -32.7 - -8.7), and household air pollution (-85.3%, UI: -92.9- -74.3) have improved. All mediating metabolic risk factors, except high blood pressure (0.7%, UI: -6.9-8.3), have worsened: BMI (110.2%, UI: 78.6-161.7), hyperglycemia (15.1%, UI: 9.3-21.2), kidney dysfunction (12.0%, UI: 8.4-17.2), and high LDL-c (11.8%, UI: 6.9-17.2). CONCLUSIONS: A variable pattern of progress and failure in controlling modifiable risk factors has been accompanied by major worsening in most metabolic risk factors. The mixed success in public health measures to control modifiable risk factors for NCDs, when gauged by the related trends in metabolic risk factors, alert to the need for stronger actions to control NCDs in the future.

Abstract INTRODUCTION: Cancers are the second main cause of morbidity worldwide, but robust information on lip, oral cavity, and pharynx cancers in Brazil is lacking. This study aimed to analyze the trends of incidence and mortality caused by lip, oral cavity, and pharynx cancers and age-period-cohort effects in the Brazilian population of 30 years of age and over, in the period of 1990 to 2019. METHODS: A time series study of the incidence and mortality rates for oral cavity and pharynx cancer (“Lip and oral cavity cancer”, “Nasopharynx cancer”, and “Other pharynx cancer”) was conducted, with corrected data from the Global Burden of Disease Study (GBD) 2019. Age-standardized rates per 100,000 inhabitants, for the global population, were gathered according to the individuals’ sex. The annual average percentage change (AAPC) was estimated, as was the age-period-cohort effects. RESULTS: The incidence and mortality rates were higher for men in the studied anatomical regions. The cancers tended to decrease for men, except for nasopharynx cancer, which increased in individuals of both sexes. Mortality tended to present a decline in most of the groups studied. For men and women, the age-period-cohort model presented a better adjustment for both incidence and mortality. CONCLUSIONS: Incidence and mortality caused by the main head and neck cancers showed a tendency to decline over the past 30 years in Brazil, except for nasopharynx cancer, which showed an increase in incidence and mortality in some segments of the population. Higher rates were found for lip and oral cavity cancers in men.

Abstract INTRODUCTION Epidemiological surveys revealed that Brazil has a high burden of oral diseases. However, no prior study has reported estimates of untreated dental caries, periodontitis, and edentulism over a three-decade period. The objective of this study is to report the trends of prevalence, incidence, and years-lived with disability (YLDs) due to untreated dental caries in primary and permanent teeth, periodontitis, and edentulism in Brazil between 1990 and 2019. METHODS Estimates of prevalence, incidence, and YLDs due to dental caries in primary and permanent teeth, periodontitis, and edentulism were produced for Brazil, by sex and age, between 1990 and 2019, using Dismod-MR 2.1, as part of the Global Burden of Disease Study 2019 (GBD 2019). Trends of oral disorders were analyzed using generalized linear regression models applying the Prais-Winsten method. RESULTS Almost 100 million Brazilians presented at least one oral disorder in 2019, which was equivalent to a prevalence of 45.3%. All oral diseases combined ranked eighth among all causes of disability, causing more than 970,000 YLDs. Untreated dental caries in primary teeth were estimated to affect 13.5 million children, and untreated dental caries in permanent teeth affected more than 52 million people. Periodontitis affected 29.5 million people, and edentulism affected almost 22 million. The generalized linear regression models revealed a trend of stability of oral disorders between 1990 and 2019. CONCLUSIONS The burden of oral diseases in Brazil is extremely high. Oral disorders, edentulism in particular, caused disability at levels that are comparable to other important chronic diseases.

Resumo Objetivo Conhecer a percepção de acolhimento e ambiência para profissionais de saúde, na perspectiva de referenciais da humanização. Métodos Trata-se de um estudo qualitativo realizado entre fevereiro e junho de 2019, com 18 profissionais de uma instituição hospitalar filantrópica de médio porte, localizada na região central do estado do Rio Grande do Sul. Os dados foram coletados com base na técnica de grupo focal e submetidos à análise de conteúdo. Resultados As duas categorias temáticas Acolhimento: da rotina à escuta qualificada; e Ambiência: da individualidade à interatividade denotam compreensões complementares. O acolhimento associa-se aos processos dialógicos e a ambiência relaciona-se às questões de conforto e aos espaços propícios à interação entre usuários, familiares e equipe de colaboradores. Conclusão O acolhimento e a ambiência hospitalar vão além de melhorias físicas e vínculos utilitaristas ou funcionais. Os mesmos podem ser considerados indutores e ampliadores de promoção da saúde, tanto de gestores e colaboradores quanto de usuários. Pressupõe-se, para tanto, processos interativos e dialógicos construídos com base em gestos simples, em atitudes respeitosas e em práticas motivadoras e potencializadoras de cuidado.

Abstract Objective To assess healthcare professionals’ perception of care and ambience, from the perspective of humanization references. Method This is a qualitative study carried out between February and June 2019, with 18 professionals from a medium-sized philanthropic hospital in the central region of the state of Rio Grande do Sul. Data were collected with the focus group technique and submitted to content analysis. Results The two thematic categories Care: from routine to qualified listening; and Ambience: from individuality to interactivity demonstrated complementary understandings. Care is associated with dialogic processes and ambience is related to comfort and to spaces that allow interaction between users, family members and staff. Conclusion Care and hospital environment go beyond physical improvements and professional or functional bonds. They can induce and enhance health promotion for managers, employees and users. They require, therefore, interactive and dialogic processes with simple gestures, respectful attitudes and motivating and health-enhancing practices.

Resumen Objetivo Conocer la percepción de acogida y ambientación para profesionales de la salud, desde la perspectiva del marco referencial de la humanización. Métodos Se trata de un estudio cualitativo realizado entre febrero y junio de 2019, con 18 profesionales de una institución hospitalaria filantrópica de porte mediano, localizada en la región central de estado de Rio Grande do Sul. Los datos fueron recopilados con base en la técnica de grupo focal y fueron sometidos al análisis de contenido. Resultados Las dos categorías temáticas Acogida: de la rutina a la escucha cualificada y Ambientación: de la individualidad a la interactividad denotan comprensiones complementarias. La acogida está asociada a los procesos dialógicos y la ambientación está relacionada con cuestiones de bienestar y con espacios propicios para la interacción entre usuarios, familiares y equipo de colaboradores. Conclusión La acogida y la ambientación hospitalaria van más allá de mejoras físicas y vínculos utilitaristas o funcionales. Estos pueden considerarse inductores y ampliadores de la promoción de la salud, tanto de administradores y colaboradores, como de usuarios. Para eso, se presupone que existan procesos interactivos y dialógicos construidos con base en gestos simples, actitudes respetuosas y prácticas motivadoras y fortalecedoras del cuidado.

Resumo O IPTU Verde constitui uma política urbana que visa estimular o desenvolvimento de ações ambientalmente sustentáveis. Com o intuito de conhecer a aplicação desse instrumento, neste trabalho analisaram-se as legislações sobre o IPTU Verde dos municípios de Minas Gerais com mais de 500 mil habitantes: Belo Horizonte, Uberlândia, Contagem e Juiz de Fora. A partir da análise dessas legislações quanto aos objetivos, critérios e benefícios, observou-se que Belo Horizonte é o único município com IPTU Verde cujo objetivo é voltado somente à conservação da biota nativa. No que tange às exigências e forma de avaliação, foram encontradas semelhanças nas leis de Belo Horizonte e Uberlândia para a proteção da flora nativa, e nas leis de Juiz de Fora e Contagem para a adoção de ações e práticas sustentáveis. Nas legislações analisadas, o benefício ocorre mediante isenção e/ou desconto no IPTU, com descontos maiores direcionados a uma proteção mais intensa da flora. Embora Belo Horizonte seja mais populoso que Uberlândia, possui menor quantidade de beneficiários, o que pode estar associado aos critérios estabelecidos em sua lei. Ademais, notou-se que os objetivos, critérios e benefícios do IPTU Verde variam conforme os interesses dos municípios, e inexistem diretrizes para a elaboração dessa política pública.

Abstract The Green IPTU is an urban policy that aims to encourage the development of environmentally sustainable actions. In order to know the application of this instrument, in this work we analyzed the legislation of the Green IPTU on the municipalities of Minas Gerais with more than 500 thousand inhabitants: Belo Horizonte, Uberlândia, Contagem and Juiz de Fora. From the analysis of these legislations regarding to objectives, criteria and benefits, it was observed that Belo Horizonte is the only municipality whose objective of the Green IPTU is aimed only at the conservation of native biota. Regarding to the requirements and form of assessment, similarities were found in the laws of Belo Horizonte and Uberlândia, for the protection of native flora, and in the laws of Juiz de Fora and Contagem, for the adoption of sustainable actions and practices. In the analyzed legislation, the benefit occurs through fiscal exemption or discount in the IPTU, with larger discounts directed to a more intense protection of the flora. Although Belo Horizonte is more populous than Uberlândia, it has a smaller number of beneficiaries, which may be associated with the criteria established in its law. In addition, it was noted that the objectives, criteria and benefits of the Green IPTU changed according to the interests of the municipalities and there are no guidelines for the elaboration of this public policy.