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Abstract The aim was to estimate the minimum number of plants required per plot to assess the anthracnose severity by artificial inoculation of V2 stage plants. Seventy-eight carioca common bean cultivars were inoculated in 13 experiments to assess its reaction to races 65, 73, 81, and 89 of Colletotrichum lindemuthianum. Sample sizes ranged from one to nine plants were adopted to setting the number of plants per plot. A total of 1000 samplings were performed for each sample size. The following parameters were estimated in each sampling: accuracy, coefficient of variation and Pearson's correlation. The mean values of each parameter in the 1000 samplings for each sample size were subjected to quadratic regression with a plateau as a function of sample size for each experiment. Six plants per plot were needed to assess the severity of anthracnose by artificially inoculating the pathogen on common bean plants at the V2 stage. V Seventyeight Seventy eight 1 65 73 81 8 lindemuthianum 100 sampling accuracy Pearsons Pearson s correlation experiment 6 7 10

https://doi.org/10.1590/1984-70332024v24n2a19

A novel fuzzy approach to identify the phenotypic adaptability of common bean lines
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Carneiro, Vinícius Quintão

; Mencalha, Jussara

; Sant’anna, Isabela de Castro

; Silva, Gabi Nunes

; Miguel, Júlio Augusto de Castro

; Carneiro, Pedro Crescêncio Souza

; Nascimento, Moysés

; Cruz, Cosme Damião

Acta Scientiarum. Agronomy

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2023, Volume 45 elocation e59854

Abstract: En | Text: En | PDF: En

ABSTRACT. The genotype by environment interaction is the main factor that influences the response of evaluated genotypes in trials of value for cultivation and use. Adaptability and stability analyses are fundamental to understanding the performance of genotypes in a growing region. Some of these methodologies incorporate previous information for recommending an extra group of genotypes denominated as specific ideotypes under certain cultivation conditions. Based on this strategy, the centroid method and its modifications have been widely used due to the simplicity of classification of the evaluated genotypes. However, these methodologies present problems in identifying adaptability patterns of some genotypes. Artificial intelligence techniques, such as fuzzy C-means, can be an alternative to reduce these difficulties, since they use, in addition to distance information between genotypes, memberships (measures quantifying how much an observation belongs to a particular class) to increase discriminatory power. Therefore, our aim was to propose and evaluate the phenotypic adaptability method by fuzzy clustering to assist cultivar recommendations. The adaptation of the fuzzy C-Means method to classify the genotypes was implemented in BioFuzzy software. The grain yield data of black common bean genotypes were used to evaluate the potential of the method. The results obtained by this method were compared with those obtained by the centroid method. The phenotypic adaptability method by fuzzy clustering was effective in identifying the adaptability patterns of common bean genotypes. Moreover, the discriminatory power was higher than that observed with the centroid method. ABSTRACT use region conditions strategy However techniques Cmeans, Cmeans C means, means C-means difficulties measures class Therefore recommendations CMeans Means software Moreover

https://doi.org/10.4025/actasciagron.v45i1.59854

Prevalence of subclinical systolic dysfunction in Takayasu's arteritis and its association with disease activity: a cross-sectional study Takayasus Takayasu s activity crosssectional cross sectional
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Figueiroa, Maria de Lourdes Castro de Oliveira

; Costa, Maria Carolina Moura

; Costa, Maria Clara Moura

; Lobo, Paulo Rocha

; Sanches, Leonardo Vinicius

; Martins, Katia Maria Alves

; Sousa, Anna Paula Mota Duque

; Pedreira, Ana Luisa Souza

; Santiago, Mittermayer Barreto

Advances in Rheumatology

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2023, Volume 63 elocation 41

Abstract: En | Text: En | PDF: En

Abstract Background Takayasu's arteritis (TA) is a vasculitis that affects the aorta and its branches and causes stenosis, occlusion, and aneurysms. Up to 60% of TA patients are associated with cardiac involvement which confers a poor prognosis. Global longitudinal strain (GLS) analysis is an echocardiographic technique that can detect the presence of subclinical systolic dysfunction. Hence, this study aimed to describe the prevalence of subclinical systolic dysfunction in patients with TA using the GLS method and to correlate this finding with disease activity using the ITAS-2010 (Indian Takayasu Activity Score). Methods Thirty patients over 18 years of age who met the American College of Rheumatology (ACR) 1990 criteria for TA were included. The sample was submitted for medical record review, clinical and echocardiographic evaluation, and application of ITAS-2010. The cutoff for systolic dysfunction was GLS > - 20%. Results Of the 30 patients analyzed, 25 (83.3%) were female, and the mean age was 42.6 years (± 13.2). The median time since diagnosis was 7.5 years [range, 3-16.6 years], and the type V angiographic classification was the most prevalent (56.7%). Regarding echocardiographic findings, the median ejection fraction (EF) was 66% [61-71%] and the GLS was - 19.5% [-21.3 to -15.8%]. Although half of the participants had reduced GLS, only two had reduced EF. Eleven patients (33.%) met the criteria for activity. An association was found between disease activity and reduced GLS in eight patients (P = 0.02) using the chi-square test. Conclusion GLS seems to be an instrument capable of the early detection of systolic dysfunction in TA. The association between GLS and disease activity in this study should be confirmed in a study with a larger sample size. Takayasus s (TA stenosis occlusion aneurysms 60 prognosis (GLS Hence ITAS2010 ITAS 2010 ITAS-201 Indian Score. Score . Score) 1 ACR (ACR 199 included review evaluation ITAS2010. 2010. 20 20% 3 analyzed 2 83.3% 833 83 (83.3% female 426 42 6 42. ± ( 13.2. 132 13.2 13 13.2) 75 7 5 7. range, range [range 316.6 3166 16.6 16 3-16. years, , years] 56.7%. 567 56.7% 56 (56.7%) findings EF (EF 66 6171% 6171 61 71% 71 [61-71% 195 19 19.5 21.3 213 21 [-21. 15.8%. 158 15.8% 15 8 -15.8%] 33.% 33 (33.% P 0.02 002 0 02 chisquare chi square test size ITAS201 201 ITAS-20 83.3 (83.3 4 13. 316 316. 166 16. 3-16 56.7 (56.7% 617 [61-71 19. 21. [-21 15.8 -15.8% 33. (33. 0.0 00 ITAS20 ITAS-2 83. (83. 31 3-1 56. (56.7 [61-7 [-2 15. -15.8 (33 0. ITAS2 ITAS- (83 3- (56. [61- [- -15. (3 (8 (56 [61 [ -15 (5 [6 -1

https://doi.org/10.1186/s42358-023-00322-2

Nomenclatural updates on names linked to the genus Axonopus for the Brazilian flora (Poaceae, Panicoideae, Paspaleae) Poaceae, Poaceae (Poaceae Panicoideae Paspaleae
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Delfini, Carolina

; Souza, Vinicius Castro

; Zuloaga, Fernando Omar

Rodriguésia

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2023, Volume 74 elocation e00502022

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A presente contribuição inclui uma atualização nomenclatural para 20 nomes relacionados ao gênero Axonopus para a flora do Brasil. Axonopus compreende aproximadamente 90 espécies, majoritariamente originárias das Américas, caracterizadas pelas espiguetas solitárias e em posição invertida. Com o objetivo de estabilizar a nomenclatura, e baseando-se no estudo minucioso de coleções originais e literatura pertinente, foram designados lectótipos para nove nomes, dos quais três são lectótipos de segundo passo. Aplicações errôneas do termo “holótipo” em contribuições anteriores também foram corrigidas a lectótipos (para quatro nomes), três casos em que a lectotipificação não é necessária foram esclarecidos, bem como discutidas quatro situações de incerteza. 2 Brasil 9 espécies Américas invertida nomenclatura baseandose baseando se pertinente passo holótipo “holótipo , nomes) esclarecidos incerteza

Abstract A nomenclatural update for 20 names related to the genus Axonopus for the Brazilian flora is here presented. Axonopus comprises around 90, mostly New World, species characterized by having solitary spikelets in an inverted position. In order to stabilize the nomenclature and, based on thorough study of original collections and pertinent literature, we designated lectotypes for nine names, of which three are second-step lectotypes. We also corrected to lectotypes erroneous applications, in previous contributions, of the term “holotype” (for four names), clarified three cases in which lectotypification is not required, as well as discussed four situations of uncertainty. 2 presented 90 World position literature secondstep second step applications contributions holotype “holotype , names) required uncertainty 9

https://doi.org/10.1590/2175-7860202374001

Recommendations by the Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology (DCNI/ABN) and the Brazilian Committee for Treatment and Research in Multiple Sclerosis and Neuroimmunological Diseases (BCTRIMS) on vaccination in general and specifically against SARS-CoV-2 for patients with demyelinating diseases of the central nervous system
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Becker, Jefferson

; Ferreira, Lis Campos

; Damasceno, Alfredo

; Bichuetti, Denis Bernardi

; Christo, Paulo Pereira

; Callegaro, Dagoberto

; Peixoto, Marco Aurélio Lana

; Sousa, Nise Alessandra De Carvalho

; Almeida, Sérgio Monteiro De

; Adoni, Tarso

; Santiago-Amaral, Juliana

; Junqueira, Thiago

; Pereira, Samira Luisa Apóstolos

; Gomes, Ana Beatriz Ayroza Galvão Ribeiro

; Pitombeira, Milena

; Paolilo, Renata Barbosa

; Grzesiuk, Anderson Kuntz

; Piccolo, Ana Claudia

; D´Almeida, José Arthur Costa

; Gomes Neto, Antonio Pereira

; Oliveira, Augusto Cesar Penalva De

; Oliveira, Bianca Santos De

; Tauil, Carlos Bernardo

; Vasconcelos, Claudia Ferreira

; Kaimen-Maciel, Damacio

; Varela, Daniel

; Diniz, Denise Sisterolli

; Oliveira, Enedina Maria Lobato De

; Malfetano, Fabiola Rachid

; Borges, Fernando Elias

; Figueira, Fernando Faria Andrade

; Gondim, Francisco De Assis Aquino

; Passos, Giordani Rodrigues Dos

; Silva, Guilherme Diogo

; Olival, Guilherme Sciascia Do

; Santos, Gutemberg Augusto Cruz Dos

; Ruocco, Heloisa Helena

; Sato, Henry Koiti

; Soares Neto, Herval Ribeiro

; Cortoni Calia, Leandro

; Gonçalves, Marcus Vinícius Magno

; Vecino, Maria Cecilia Aragón De

; Pimentel, Maria Lucia Vellutini

; Ribeiro, Marlise De Castro

; Boaventura, Mateus

; Parolin, Mônica Koncke Fiuza

; Melo, Renata Brant De Souza

; Lázaro, Robson

; Thomaz, Rodrigo Barbosa

; Kleinpaul, Rodrigo

; Dias, Ronaldo Maciel

; Gomes, Sidney

; Lucatto, Simone Abrante

; Alves-Leon, Soniza Vieira

; Fukuda, Thiago

; Ribeiro, Taysa Alexandrino Gonsalves Jubé

; Winckler, Thereza Cristina D’ávila

; Fragoso, Yara Dadalti

; Nascimento, Osvaldo José Moreira Do

; Ferreira, Maria Lucia Brito

; Mendes, Maria Fernanda

; Brum, Doralina Guimarães

; Glehn, Felipe Von

Arquivos de Neuro-Psiquiatria

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nov 2021, Volume 79 N. 11 Pages 1049 - 1061

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O DC de Neuroimunologia da ABN e o BCTRIMS trazem, nesse documento, as recomendações sobre vacinação da população com doenças desmielinizantes do sistema nervoso central (SNC) contra infecções em geral e contra o coronavírus da síndrome respiratória aguda grave 2 (SARS-CoV-2), causador da COVID-19. Destaca-se a gravidade do atual momento frente ao avanço da COVID-19 em nosso País, o que torna mais evidente e importante a criação de guia de referência para orientação aos médicos, pacientes e autoridades de saúde pública quanto à vacinação, meio efetivo e seguro no controle de determinadas doenças infecciosa. O DCNI/ABN e o BCTRIMS recomendam que os pacientes com doenças desmielinizantes do SNC (ex., EM e NMOSD) sejam constantemente monitorados, quanto a atualização do seu calendário vacinal, especialmente, no início ou antes da mudança do tratamento com uma droga modificadora de doença (DMD). É importante também salientar que as vacinas são seguras e os médicos devem estimular o seu uso em todos os pacientes. Evidentemente, deve ser dada especial atenção às vacinas com vírus vivos atenuados. Por fim, é importante que os médicos verifiquem qual DMD o paciente está em uso e quando foi feita a sua última dose, pois cada fármaco pode interagir de forma diferente com a indução da resposta imune.

ABSTRACT The Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology (DCNI/ABN) and Brazilian Committee for Treatment and Research in Multiple Sclerosis and Neuroimmunological Diseases (BCTRIMS) provide recommendations in this document for vaccination of the population with demyelinating diseases of the central nervous system (CNS) against infections in general and against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19. We emphasize the seriousness of the current situation in view of the spread of COVID-19 in our country. Therefore, reference guides on vaccination for clinicians, patients, and public health authorities are particularly important to prevent some infectious diseases. The DCNI/ABN and BCTRIMS recommend that patients with CNS demyelinating diseases (e.g., MS and NMOSD) be continually monitored for updates to their vaccination schedule, especially at the beginning or before a change in treatment with a disease modifying drug (DMD). It is also important to note that vaccines are safe, and physicians should encourage their use in all patients. Clearly, special care should be taken when live attenuated viruses are involved. Finally, it is important for physicians to verify which DMD the patient is receiving and when the last dose was taken, as each drug may affect the induction of immune response differently.

https://doi.org/10.1590/0004-282x-anp-2021-0162 1 downloads

Analgesic effects of Phα1β toxin: a review of mechanisms of action involving pain pathways
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Silva, Juliana Figueira da

; Binda, Nancy Scardua

; Pereira, Elizete Maria Rita

; Lavor, Mário Sérgio Lima de

; Vieira, Luciene Bruno

; Souza, Alessandra Hubner de

; Rigo, Flávia Karine

; Ferrer, Hèlia Tenza

; Castro Júnior, Célio José de

; Ferreira, Juliano

; Gomez, Marcus Vinicius

Journal of Venomous Animals and Toxins including Tropical Diseases

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2021, Volume 27 elocation e20210001

Abstract: En | Text: En | PDF: En

Abstract Phα1β is a neurotoxin purified from spider venom that acts as a high-voltage-activated (HVA) calcium channel blocker. This spider peptide has shown a high selectivity for N-type HVA calcium channels (NVACC) and an analgesic effect in several animal models of pain. Its activity was associated with a reduction in calcium transients, glutamate release, and reactive oxygen species production from the spinal cord tissue and dorsal ganglia root (DRG) in rats and mice. It has been reported that intrathecal (i.t.) administration of Phα1β to treat chronic pain reverted opioid tolerance with a safer profile than ω-conotoxin MVIIA, a highly selective NVACC blocker. Following a recent development of recombinant Phα1β (CTK 01512-2), a new molecular target, TRPA1, the structural arrangement of disulphide bridges, and an effect on glial plasticity have been identified. CTK 01512-2 reproduced the antinociceptive effects of the native toxin not only after the intrathecal but also after the intravenous administration. Herein, we review the Phα1β antinociceptive activity in the most relevant pain models and its mechanisms of action, highlighting the impact of CTK 01512-2 synthesis and its potential for multimodal analgesia.

https://doi.org/10.1590/1678-9199-jvatitd-2021-0001

Phosphorus supplementation does not affect the intake, digestibility, and meat quality of Nellore young bulls fed with high-grain diets
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Lima, Laís de Oliveira

; Souza, Vinícius Carneiro de

; Messana, Juliana Duarte

; Castagnino, Pablo de Souza

; Lima, Ana Rebeca Castro

; Berchielli, Telma Teresinha

Acta Scientiarum. Animal Sciences

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2021, Volume 43 elocation e50347

Abstract: En | Text: En | PDF: En

ABSTRACT. This study evaluated the effect of phosphorus (P) supplementation on the intake, digestibility, and quality of aged meat from Nellore young bulls fed on high-grain diets finished in feedlot. Forty young bulls (30 months old) with an initial body weight (IBW) of 296 ± 25 kg were used. It was distributed in a completely randomized experimental design. The treatments were: without P supplementation (CO), commercial mineral supplement (CM), and supplementation with dicalcium phosphate (DP) with 2.4, 4.2, or 5.0 g of P per kg of dry matter (DM), respectively. Diets were composed of sugarcane bagasse (200 g kg-1) plus concentrate (800 g kg-1) on a dry matter (DM) basis. The meat quality parameters analyzed were pH, color, cooking losses, shear force, and water-holding capacity. P supplementation did not affect the intake and digestibility of nutrients There was no interaction (p > 0.05%) between diets and the aging time for the meat quality parameters. However, bulls fed with DP exhibited lower pH (5.98) compared to CO and CM (6.19 and 6.14, respectively). The longer aging time increased the cooking losses and intensity of yellow (b*). Under Brazilian conditions, feedlot Nellore cattle fed with high-grain diets do not require additional mineral supplements.

https://doi.org/10.4025/actascianimsci.v43i1.50347 534 downloads

Buchnera nordestina (Orobanchaceae), an overlooked new species from Northeast Brazil, with an updated identification key for Buchnera of Brazil
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Scatigna, André Vito

; Saraiva, Raysa Valéria Carvalho

; Couto, Arthur Filipe Mendes

; Souza, Vinicius Castro

; Muniz, Francisca Helena

Acta Botanica Brasilica

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dec 2020, Volume 34 N. 4 Pages 789 - 795

Abstract: En | Text: En | PDF: En

ABSTRACT A new species of Buchnera (Orobanchaceae) from Northeast Brazil is described and illustrated. Buchnera nordestina was first collected by Dr. Francisco Freire Allemão e Cysneiro ca. 160 years ago and remained undescribed until now. We provide notes on morphology, geographic distribution, and conservation status of the new species. Additionally, we present an updated identification key to all species of Buchnera from Brazil. Buchnera nordestina is characterized by long bracts that are usually two times longer than the calyx tube and by the presence of axillary brachyblasts, both of which are unique features within the genus. The new species occurs in restinga and cerrado vegetation in the Brazilian states of Ceará, Maranhão, and Piauí, and is assessed as Endangered (EN).

https://doi.org/10.1590/0102-33062020abb0333 760 downloads

Health work in the context of a pandemic: For a research agenda
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Ramos, Flávia Regina Souza

; Lacerda, Marcus Vinicius Guimarães

; Ferreira, Darlisom Sousa

; Lima, Kássia Janara Veras

; Tavares, Igor Castro

; Monteiro, Wagner Ferreira

; Martins, Cleise Maria de Goes

; Silva, George Lucas Augusto Trindade da

; Andrade, Lucas Lorran Costa de

; Monteiro, Wuelton Marcelo

Revista da Sociedade Brasileira de Medicina Tropical

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2020, Volume 53 elocation e20200427

Abstract: En | Text: En | PDF: En

Abstract INTRODUCTION: The emergence of a pandemic highlights the translational demands regarding science. This communication aims to propose theoretical-methodological elements for research on health work in pandemic context. METHODS: This reflective essay sets an framework for a research project on health work in Manaus, Amazonas, Brazil. RESULTS: Three axes or subsidies are presented: the construction of work environments as an analytical component, the approach of ergology as a potential and the centrality of the experiences of the worker-subject. CONCLUSIONS: New health care challenges require attention to what workers have to say about their forms of confrontation and translation of knowledge.

https://doi.org/10.1590/0037-8682-0427-2020 433 downloads

10.

Brasil y la integración regional
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Castro Madureira, Vinícius de Carvalho

; de Souza, Carolina Paula

Estado & comunes, revista de políticas y problemas públicos

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dec 2019, Volume 2 N. 9 Pages 199 - 210

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Las iniciativas de integración política, física y comercial de América del Sur han recibido atención especial desde el último cuarto del siglo XX. La intelectualidad brasileña trata ampliamente dicho tema, pudiendo ser encontrado en los estudios de Mário Travassos, en la Política de Defensa Nacional y, de forma explícita, en el artículo n.º 4, de la Constitución Federal de 1988, que prevé el intento de la “integración económica, política, social y cultural de los pueblos de América Latina, buscando la formación de una comunidad latinoamericana de naciones” como uno de los objetivos de la República Federativa del Brasil. En este artículo, nuestro objetivo es discutir la relación del Brasil frente a la integración regional y hablar, brevemente, acerca del actual momento. Para eso, hemos hecho una investigación exploratoria por medio de revisión bibliográfica. Como resultados, pudimos notar que la integración es esencial para la proyección internacional brasileña, aunque todavía, en detrimento de su importancia, aún no ha sido consolidada.

Abstract The political, physical and commercial integration initiatives of South America have received special attention since the last quarter of the 20th century. The Brazilian scholars deals extensively with this topic, which can be found in the studies of Mário Travassos, in the National Defense Policy and, explicitly, in the sole paragraph of the article 4 of the Federal Constitution of 1988, which foresees the search for “economic, political, social and cultural integration of the peoples of Latin America, viewing the formation of a Latin-American community of nations”, as one of the objectives of the Federative Republic of Brazil. In this paper, our objective is to discuss Brazil’s relationship with regional integration and to discuss, briefly, the current moment. For that, we have done exploratory research through bibliographic review. As results, we could note that the regional integration is essential for the Brazilian international projection, however, despite of its importance, it has not yet been built up.

https://doi.org/10.37228/estado_comunes.v2.n9.2019.125 8 downloads

11.

Projeto Gestão e Gentileza nos plantões noturnos de um hospital universitário: relato de experiência
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Zocratto, Keli Bahia Felicíssimo

; Lopes, Tânia Assis Souza

; Costa, Marcus Vinícius da Silva

; Viana, Sônia Maria Nunes

; Camargos, Mirela Castro Santos

Saúde em Debate

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jun 2019, Volume 43 N. 121 Pages 636 - 644

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O presente estudo teve por objetivo descrever a experiência de implantação do Projeto de Extensão Gestão e Gentileza nos plantões noturnos de um hospital universitário, de janeiro a dezembro de 2017, explicitando a articulação entre o conhecimento teórico adquirido em diversas disciplinas do Curso de Gestão de Serviços de Saúde e a prática extensionista. O projeto, direcionado aos trabalhadores noturnos, buscou ressaltar a importância desses funcionários no ambiente hospitalar por meio de intervenções de gestão e gentileza em sete unidades do Hospital. A articulação entre teoria e prática perpassou pelas diversas etapas do projeto, contribuindo para a formação de profissionais capazes de intervir no cotidiano das organizações de saúde de maneira inovadora e efetiva. A vivência no projeto certificou a urgência de pensar intervenções permeadas por ações de gentileza em que todos os profissionais tenham condições de participar e se beneficiar com os resultados.

ABSTRACT The present study aims to describe the experience of implementing the Extension Project Management and Kindness in the night shifts of a university hospital, from January to December 2017, showing the articulation between the theoretical knowledge acquired in several subjects of the Health Services Management Course and the extension practice. The project, aimed at night workers, sought to highlight their importance in the hospital environment by means of management and kindness in seven hospital units. The articulation between theory and practice permeated the various stages of the project, contributing to the formation of professionals capable of intervening in the daily life of health organizations in an innovative and effective way. The experience in the project certified the urgency to think of interventions permeated by actions of kindness in which all professionals are able to participate and benefit from the results.

https://doi.org/10.1590/0103-1104201912127

12.

Movimentos de reforma do sistema de saúde do Distrito Federal: a conversão do modelo assistencial da Atenção Primária à Saúde
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Corrêa, Daniel Seabra Resende Castro

; Moura, Alexandra Gouveia de Oliveira Miranda

; Quito, Marcus Vinícius

; Souza, Heloiza Machado de

; Versiani, Luciana Martins

; Leuzzi, Sérgio

; Gottems, Leila Bernarda Donato

; Macinko, James

Ciência & Saúde Coletiva

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jun 2019, Volume 24 N. 6 Pages 2031 - 2041

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O Sistema Único de Saúde tem passado por constante evolução e ampliação desde a publicação da Constituição Federal de 1988. O Distrito Federal apresentou contribuições no campo da Política de Atenção Primária à Saúde, sobretudo entre os anos 2016 e 2018, ao definir a Estratégia Saúde da Família como forma definitiva de organização dos serviços na APS e estabelecer um conjunto de ações orientadas para a conversão ao modelo. Esse artigo descreve e analisa os principais processos dessa mudança. Utilizou-se o método de análise documental de portarias, resoluções, relatórios e outros documentos, bem como dados disponíveis nas bases oficiais. Destacam-se a elaboração de um arcabouço normativo que inclui a implantação das equipes, os processos de trabalho dos profissionais, mudanças nas especialidades médicas e reordenamento dos profissionais de saúde que já atuavam na APS. A experiência demonstra a viabilidade de mudanças incrementais nas políticas de saúde em prol da ampliação de acesso da população aos serviços de saúde, por meio da definição de prioridades, melhor gestão da força de trabalho, capacitação e planejamento descentralizado, repercutindo na elevação da cobertura populacional de Saúde da Família dos iniciais 28% para 69%, alcançados em um período de dois anos.

Abstract Conclusion The Unified Health System has undergone constant evolution and expansion since the publication of Brazil’s 1988 Federal Constitution. The Federal District has provided contributions to the field of Primary Health Care Policy, especially between 2016 and 2018, by defining the Family Health Strategy as the definitive way of organizing Primary Health Care (PHC) services and by establishing a set of actions aimed at conversion of existing PHC services to this model. This article describes and analyzes the key processes of this change. The method used was analysis of ordinances, resolutions, reports and other documents, as well as assessment of data from official databases. We emphasize the development of a normative structure that includes the teams’ implementation, the professionals’ work processes, changes in medical specialties and reorganization of the health professionals who already worked in PHC. with an effect of increasing the population’s Family Health Strategy coverage (in a population of approximately 3 million inhabitants) from 28% to 69% during a two-year period, the experience demonstrates the feasibility of incremental changes in health policies such as defining priorities, better management of the workforce, training and decentralized planning to increase access to health services.

https://doi.org/10.1590/1413-81232018246.08802019

13.

Movimentos de reforma do sistema de saúde do Distrito Federal: a conversão do modelo assistencial da Atenção Primária à Saúde
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Corrêa, Daniel Seabra Resende Castro

; Moura, Alexandra Gouveia de Oliveira Miranda

; Quito, Marcus Vinícius

; Souza, Heloiza Machado de

; Versiani, Luciana Martins

; Leuzzi, Sérgio

; Gottems, Leila Bernarda Donato

; Macinko, James

Ciência & Saúde Coletiva

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jun 2019, Volume 24 N. 6 Pages 2031 - 2041

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232018246.08802019 2837 downloads

14.

Projeto Gestão e Gentileza nos plantões noturnos de um hospital universitário: relato de experiência
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Zocratto, Keli Bahia Felicíssimo

; Lopes, Tânia Assis Souza

; Costa, Marcus Vinícius da Silva

; Viana, Sônia Maria Nunes

; Camargos, Mirela Castro Santos

Saúde em Debate

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apr 2019, Volume 43 N. 121 Pages 636 - 644

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/0103-1104201912127 629 downloads

15.

Antineoplastic Effect of Procyanidin-rich Extract of Lafoensia Pacari in Lung Carcinoma Cells
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Cordeiro, Yonara de Gouveia

; Rochetti, Arina Lázaro

; Souza, Vinicius Castro

; Silva, Edson Roberto da

; Scatolini, Antônio Márcio

; Genovese, Maria Inés

; Yasui, George Shigueki

; Fukumasu, Heidge

Brazilian Archives of Biology and Technology

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2019, Volume 62 elocation e19160638

Abstract: En | Text: En | PDF: En

Abstract Lafoensia pacari A. St. Hill has been used in traditional medicine as an anti-ulcerogenic and anti-inflammatory. Although there is an ethnopharmacological indication for cancer treatment, only a few studies have demonstrated its possible anticancer activity. Thus, the aims of this study were: (1) to evaluate the antineoplastic effect of L. pacari ethanolic extract (LPE) in lung carcinoma cells, (2) to determine the mode of action of LPE and (3) to identify the substances present in LPE. Human and murine lung cancer cell lines were grown in vitro and treated with different concentrations of LPE. Cell cycle and caspase-3 activity assays were performed in order to verify the mode of action. LC-ESI-MS screening was performed to detect the compounds present in LPE. LPE showed a dose-dependent cytotoxic effect, where neoplastic cells were more sensitive than non-neoplastic. The LPE induced sub-G1 cell cycle arrest in cancer cells suggesting cell death, which was confirmed as apoptosis by the activation of caspase-3. The LC-ESI-MS analysis indicated a high level of procyanidins, which could be responsible for the antineoplastic effect of LPE. Thus, we concluded that a Lafoensia pacari extract, rich in procyanidins, is cytotoxic against lung cancer cells through activation of caspase-3-dependent apoptosis.

https://doi.org/10.1590/1678-4324-2019160638 848 downloads

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