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RESUMO O presente artigo tem como objetivo analisar, sob a perspectiva bakhtiniana, a construção grotesca do corpo fridiano por meio de uma cosmovisão religiosa. Para tanto, são analisados dois autorretratos produzidos pela pintora mexicana Frida Kahlo, levando em consideração as relações dialógicas construídas entre as representações grotescas e as simbologias católicas. Nos enunciados analisados, nos quais são depreendidas as especificidades da competência criativa da autora-criadora em sua atividade estética, percebe-se o correlacionamento entre a pintura El venado herido e a narrativa do santo católico São Sebastião e o diálogo entre a tela Las dos fridas e a imagem do Sagrado Coração de Jesus. analisar bakhtiniana religiosa tanto Kahlo católicas autoracriadora autora criadora estética percebese percebe se Jesus

ABSTRACT This article aims to analyze, from a Bakhtinian perspective, the grotesque construction of Mexican artist Frida Kahlo’s body through a religious worldview. Therefore, we analyze two of her self-portraits, taking into account the dialogic relations constructed between the grotesque representations and Catholic symbology. The analyzed utterances, in which the specificities of the creative competence of the author-creator in her aesthetic activity are inferred, showed that a dialogue is established between the painting El venado herido and Catholic Saint Sebastian and between the painting Las dos fridas and the image of the Sacred Heart of Jesus. perspective Kahlos Kahlo s worldview Therefore selfportraits, selfportraits self portraits, portraits self-portraits symbology utterances authorcreator author creator inferred Jesus

https://doi.org/10.1590/2176-4573p63572

Prevalence and antimicrobial resistance profile of pathogens isolated from patients with urine tract infections admitted to a university hospital in a medium-sized Brazilian city mediumsized medium sized
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Negri, Mariana

; Lima, Bárbara Martins

; Woloszynek, Renata dos Santos Batista Reis

; Molina, Roberto Augusto Silva

; Germano, Carla Maria Ramos

; Melo, Débora Gusmão

; Souza, Leandro Cândido de

; Avó, Lucimar Retto da Silva de

Revista do Instituto de Medicina Tropical de São Paulo

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2024, Volume 66 elocation e3

Abstract: En | Text: En | PDF: En

ABSTRACT This study aimed to determine the antibiotic profile of microorganisms isolated from urine samples of patients with community urine tract infections (UTI) admitted to the University Hospital of the Federal University of Sao Carlos to support an appropriate local empirical treatment. A retrospective cross-sectional study was conducted from October 2018 to October 2020. Data from 1,528 positive urine cultures for bacterial pathogens and antibiograms were tabulated. Bacterial species prevalence and their resistance profile were analyzed and compared by sex and age. For Gram-negative fermenting bacteria, resistance rates were compared between patients with previous hospitalization and the total of infections caused by this group. For comparisons, the Chi-square test was performed, using Fisher’s exact test when necessary (BioEstat program, adopting p ≤ 0.05). A multivariate analysis was applied to assess the effect of the studied variables in predicting multidrug resistance. Infections were more prevalent in women and older adults. Gram-negative bacteria represented 90.44% of total cultures. In both sexes, E. coli prevalence was significantly higher in adults compared with older adults (p < 0.0001). For several antibiotics, resistance rates were higher in the older adults compared with other ages and in patients with Gram-negative fermenting infections and previous hospitalization compared with the total of infections by this group of bacteria. The closer to the hospitalization, the higher the number of antibiotics with superior resistance rates. Resistance rates for aminoglycosides, carbapenems, ceftazidime, nitrofurantoin, piperacillin+tazobactam, and fosfomycin were less than 20%, considered adequate for empirical treatment. Only hospitalization in the previous 90 days was statistically significant in predicting infections by multidrug-resistant bacteria. UTI (UTI treatment crosssectional cross sectional 201 2020 1528 1 528 1,52 tabulated age Gramnegative Gram negative comparisons Chisquare Chi square performed Fishers Fisher s BioEstat program 0.05. 005 0.05 . 0 05 0.05) 9044 44 90.44 sexes E 0.0001. 00001 0.0001 0001 0.0001) aminoglycosides carbapenems ceftazidime nitrofurantoin piperacillintazobactam piperacillin tazobactam piperacillin+tazobactam 20 20% 9 multidrugresistant resistant 202 152 52 1,5 00 0.0 904 4 90.4 0000 0.000 000 2 15 5 1, 0. 90. 0.00

https://doi.org/10.1590/s1678-9946202466003

Effect of Dioscorea villosa extract and the phytoestrogen diosgenin on ovariectomized mice with zymosan-induced arthritis zymosaninduced zymosan induced
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Silva, Luiz André Santos

; Araújo, Jéssica Maria Dantas

; Almeida, Damião Rabelo de

; Araújo, Luiz Felipe Lobo Mascarenhas Fratel de

; Souza, Eloísa Portugal Barros Silva Soares de

; Matos, Saulo Santos

; Lima, Cláudio Moreira de

; Araújo, Adriano Antunes de Souza

; Camargo, Enilton Aparecido

; Grespan, Renata

Brazilian Journal of Pharmaceutical Sciences

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2024, Volume 60 elocation e23203

Abstract: En | Text: En | PDF: En

Abstract Humans are exposed to natural compounds such as phytoestrogens primarily through diet and supplements. These compounds promote health by alleviating the symptoms and illnesses associated with menopause and arthritis. Diosgenin (DSG) occurs naturally in plants such as Dioscorea villosa (DV) and binds to estrogen receptors, so it may have similar effects to this hormone, including against arthritis. Thus, we investigated the effect of chronic treatment with dry extract of DV and its phytoestrogen DSG on ovariectomized mice with arthritis. We found that dry extract of Dioscorea villosa (DV) contains the phytoestrogen diosgenin (DSG) in its composition. Furthermore, arthritic mice treated with DV and DSG showed reduced neutrophil accumulation in the articular cartilage. Also, the dry extract of DV administered orally (v.o) did not alter the leukocyte count in the joints or promote changes in the reproductive tract. However, DSG altered these parameters, with possible beneficial effects by reducing symptoms related to reproductive aging. Thus, oral treatment with dry extract of DV and subcutaneous (s.c) treatment with DSG showed promise by acting against inflammation caused by arthritis and reducing symptoms in the reproductive tract due to menopause. supplements (DSG (DV receptors hormone Thus composition Furthermore cartilage Also v.o vo v o (v.o However parameters aging s.c sc s c (s.c

https://doi.org/10.1590/s2175-97902024e23203

Efeitos da bandagem elástica na dor orofacial e nos movimentos mandibulares após 24 horas de uso: ensaio clínico randomizado 2 uso
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Faria, Marília dos Santos

; Teodoro, Gabriela Carolina Silva

; Silva, Júlia Ana Soares

; Emérito, Tatyana Meneses

; Motta, Andréa Rodrigues

; Amaral, Mariana Souza

; Furlan, Renata Maria Moreira Moraes

CoDAS

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2024, Volume 36 N. 3 elocation e20230066

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo Analisar a sensação de dor e amplitude dos movimentos mandibulares de indivíduos adultos com disfunção temporomandibular, antes e após aplicação da bandagem elástica por 24 horas. Método Trata-se de um ensaio clínico randomizado duplo-cego, do qual participaram 22 sujeitos adultos com disfunção temporomandibular, alocados aleatoriamente em dois grupos, sendo grupo A composto por 10 mulheres e um homem (média de idade de 28,2±8,3 anos) e grupo B por nove mulheres e dois homens (média de idade de 26,2±3,9 anos). Todos os participantes foram submetidos à aplicação do Diagnostic Criteria for Temporomandibular Disorders (DC/TMD). Foi realizada a avaliação do limiar da dor, com uso de um algômetro, para aplicação da pressão no masseter e temporal e medição dos movimentos mandibulares, com paquímetro. O grupo A foi submetido à aplicação da bandagem sobre o músculo masseter com estiramento de 40% e o grupo B sem estiramento. A colagem da bandagem foi realizada, com corte em “I”, com ponto fixo sobre a inserção e ponto móvel sobre a origem do músculo masseter. Os participantes permaneceram com a bandagem por 24 horas e foram reavaliados. Resultados Houve alívio da dor no grupo A na articulação temporomandibular à direita e na origem do masseter à esquerda. O grupo B apresentou redução da dor em região de temporal anterior à esquerda. Não foram encontradas diferenças nos movimentos mandibulares após intervenção, bem como não houve diferença na comparação entre os grupos. Conclusão O uso da bandagem sobre o masseter, por 24 horas, com estiramento, produziu alívio da dor na origem do masseter direito e na região da articulação temporomandibular direita e, sem estiramento, no temporal anterior esquerdo. Não houve diferença na amplitude de movimentos mandibulares. 2 Tratase Trata se duplocego, duplocego duplo cego, cego duplo-cego grupos 1 média 28283 28 8 3 28,2±8, anos 26239 26 9 26,2±3, anos. . DC/TMD. DCTMD DC/TMD DC TMD (DC/TMD) algômetro paquímetro 40 I, I , “I” reavaliados esquerda intervenção esquerdo 2828 28,2±8 2623 26,2±3 (DC/TMD 4 “I 282 28,2± 262 26,2± 28,2 26,2 28, 26,

ABSTRACT Purpose To analyze the sensation of pain and the range of mandibular movements of adult individuals with temporomandibular disorder, before and after the application of the athletic tape. Method This is a double-blind randomized clinical trial, in which 22 adults with temporomandibular disorder participated, randomly allocated into two groups, with group A comprising 10 women and one man (mean age 28.2±8.3 years) and group B comprising nine women and two men (mean age 26.2±3.9 years). Group A was submitted to the application of the athletic tape on the masseter with 40% stretch and the group B to the application of the athletic tape on the masseter without stretching. All participants underwent the application of the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD). Pain threshold assessment was performed using an algometer to apply pressure to measurement points. The measurement of mandibular movements was performed using a caliper. The athletic tape was glued using the I technique, with a fixed point over the insertion and a movable point over the origin of the masseter muscle. Participants remained with the athletic tape for 24 hours and were re-evaluated. Results There was pain relief in the group A in the temporomandibular joint on the right and at the origin of the masseter on the left. The group B showed a reduction in pain in the left anterior temporal region. No differences were found in mandibular movements after intervention, as well as no difference was found in the comparison by groups. Conclusion The use of the athletic tape over the masseter muscle, with stretching, for 24 hours produced relief from the sensation of pain, on the origin of the right masseter and in the right temporomandibular joint, and, without stretching, in the left anterior temporal muscle. There was no difference in the range of mandibular movements. doubleblind double blind trial 2 participated groups 1 mean 28283 28 8 3 28.2±8. years 26239 26 9 26.2±3. years. . 40 stretching DC/TMD. DCTMD DC/TMD DC TMD (DC/TMD) points caliper technique muscle reevaluated. reevaluated re evaluated. evaluated re-evaluated region intervention 2828 28.2±8 2623 26.2±3 4 (DC/TMD 282 28.2± 262 26.2± 28.2 26.2 28. 26.

https://doi.org/10.1590/2317-1782/20242023066pt

Effect of curcumin and three analogues on pre-osteoblast cells’ viability, differentiation, and gene expression preosteoblast pre osteoblast cells viability differentiation
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Sá, Ana Flor

; Diniz, Ivana Márcia Alves

; Oliveira, Renata Barbosa de

; Diniz, Marina Gonçalves

; Cortés, Maria Esperanza

; Souza, Letícia Lopes de

; Olórtegui, Carlos Delfin Chávez

; Lages, Frederico Santos

Brazilian Oral Research

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2024, Volume 38 elocation e123

Abstract: En | Text: En | PDF: En

Abstract Curcumin, found in turmeric rhizomes (Curcuma longa L.), has been widely studied for its potential health benefits, including anti-inflammatory, antioxidant, and wound-healing properties. However, due to its low bioavailability and unfavorable pharmacokinetics, analogous compounds have been developed to obtain better biopharmaceutical characteristics and enhanced biological effects. In this study, we evaluated the activity of curcumin and three of its synthetic analogues (DMAD, DMAM, and RI75) on the viability and differentiation of a pre-osteoblastic cell line (MC3T3-E1). We also assessed the expression of key genes involved in tissue regeneration: vascular endothelial growth factor (vegf), stromal-derived growth factor 1 (SDF-1/CXCL12), and runt-related transcription factor 2 (runx2). The cells were treated with curcumin and the three analogues at concentrations of 10, 30, or 50 μM. All tested analogues and curcumin exhibited moderate to no cell toxicity compared to the cells treated under standard conditions across all concentrations after 24, 48, and 72 hours. Only the RI75 analogue showed upregulation of SDF-1, a crucial factor in tissue regeneration. Compared to curcumin, the DMAM and RI75 analogues also upregulated runx2 and vegf, both associated with osteodifferentiation. The RI75 analogue demonstrated greater mineralization than curcumin, and both promoted more nodule formation than the untreated control. Our data suggest that the curcumin analogue RI75 at 50 μM presents similar toxicity but enhanced biological activity compared to natural curcumin, making it a promising substance for material biomodifications. Curcumin Curcuma L., L L. , L.) benefits antiinflammatory, antiinflammatory anti inflammatory, inflammatory anti-inflammatory antioxidant woundhealing wound healing properties However pharmacokinetics effects study DMAD, DMAD (DMAD RI preosteoblastic pre osteoblastic MC3T3E1. MC3T3E1 MCTE MC3T3 E1 . MC T E (MC3T3-E1) regeneration vegf (vegf) stromalderived stromal derived SDF1/CXCL12, SDF1CXCL12 SDFCXCL SDF 1/CXCL12 CXCL12 CXCL (SDF-1/CXCL12) runtrelated runt related runx2. runx (runx2) 10 30 5 24 48 7 hours RI7 SDF1, SDF1 1, SDF-1 osteodifferentiation control biomodifications MC3T3E MCT MC3T (MC3T3-E1 (vegf SDF1/CXCL12 SDF1CXCL1 1CXCL12 1/CXCL1 CXCL1 (SDF-1/CXCL12 (runx2 3 4 SDF- (MC3T3-E SDF1/CXCL1 SDF1CXCL 1CXCL1 1/CXCL (SDF-1/CXCL1 (runx SDF1/CXCL 1CXCL (SDF-1/CXCL

https://doi.org/10.1590/1807-3107bor-2024.vol38.0123

Adequação do Consumo de Ácidos Graxos entre Pacientes em Prevenção Cardiovascular Secundária
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Marcadenti, Aline

; Machado, Rachel H. Vieira

; Santos, Renato Hideo Nakagawa

; Kasai, Caio Cesar dos Santos

; Kovacs, Cristiane

; Bello, Annie

; de Matos, Cristina H.

; Bertacco, Renata Torres Abib

; Souza, Gabriela C.

; Schirmann, Gabriela da S.

; Nagano, Francisca Eugenia Zaina

; Poloni, Soraia

; Kik, Raquel Milani El

; Feres, Naoel Hassan

; Rodrigues, Isa G.

; Sousa, Antônio Carlos Sobral

; Pinheiro, Josilene M. F.

; Vasconcelos, Sandra Mary Lima

; Carlos, Daniele Maria de Oliveira

; Souza, Viviane Sahade

; Gomes, Adriana Barros

; Figueiredo Neto, José Albuquerque de

; Moriguchi, Emilio Hideyuki

; Izar, Maria Cristina

; Pinto, Sônia Lopes

; Bressan, Josefina

; de Souza, Simone Raimondi

; Kumbier, Magali C.

; de Araújo, Celme Barroncas Passos

; Torreglosa, Camila R.

; Weber, Bernardete

; Bersch-Ferreira, Ângela Cristine

Arquivos Brasileiros de Cardiologia

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2024, Volume 121 N. 3 elocation e20230487

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamento: A adesão à uma alimentação adequada em macronutrientes é fundamental para a prevenção secundária de doenças cardiovasculares. Objetivo: Avaliar a prevalência de adesão às recomendações de consumo de ácidos graxos para prevenção e tratamento de doenças cardiovasculares, e estimar se a presença de determinados fatores de risco cardiovascular estaria associada à adesão. Métodos: Estudo transversal com os dados de linha de base de 2358 participantes do estudo "Brazilian Cardioprotective Nutritional Program Trial". Dados de consumo alimentar, e fatores de risco cardiovascular foram avaliados. Foi considerada, de acordo com a Sociedade Brasileira de Cardiologia, uma ingestão adequada de ácidos graxos poli-insaturados (AGPI) ≥10% do consumo total de energia diária, para ácidos graxos monoinsaturados (AGM), 20% e para ácidos graxos saturados (AGS), <7%. Na análise estatística foi considerando nível de significância de 5%. Resultados: Nenhum participante aderiu a todas as recomendações de forma simultânea e mais da metade (1482 [62,9%]) não aderiu a nenhuma recomendação. A adesão exclusivamente à recomendação de AGS foi a mais prevalente, sendo cumprida por 659 (28%) dos participantes, seguida da adesão exclusivamente à recomendação de AGP (178 [7,6%]) e de AGM (5 [0,2%]). Não houve associação entre o número de comorbidades e a adesão às recomendações nutricionais (p =0,269). Os participantes da região Nordeste do país apresentaram maior proporção de adesão às recomendações para consumo de AGS (38,42%), e menor para ingestão de AGPI (3,52%) (p <0,001) em comparação às demais. Conclusões: Na amostra avaliada, evidenciou-se baixa adesão às recomendações nutricionais para consumo de ácidos graxos. Fundamento cardiovasculares Objetivo Métodos 235 Brazilian Trial. Trial . Trial" alimentar avaliados considerada Cardiologia poliinsaturados poli insaturados (AGPI 10 ≥10 diária AGM, , (AGM) 20 AGS, (AGS) 7 <7% 5 5% Resultados 1482 (148 62,9% 629 62 9 [62,9%] prevalente 65 28% 28 (28% 178 (17 7,6% 76 6 [7,6%] ( 0,2%. 02 0,2% 0 2 [0,2%]) p =0,269. 0269 =0,269 269 =0,269) 38,42%, 3842 38,42% 38 42 (38,42%) 3,52% 352 3 52 (3,52% <0,001 0001 001 demais Conclusões avaliada evidenciouse evidenciou 23 1 ≥1 (AGM (AGS <7 148 (14 62,9 [62,9% (28 17 (1 7,6 [7,6% 0,2 [0,2%] 026 =0,26 26 384 38,42 4 (38,42% 3,52 35 (3,52 <0,00 000 00 ≥ < 14 62, [62,9 (2 7, [7,6 0, [0,2% =0,2 38,4 (38,42 3,5 (3,5 <0,0 [62, [7, [0,2 =0, 38, (38,4 3, (3, <0, [62 [7 [0, =0 (38, (3 <0 [6 [ [0 = (38

Background: Adhering to a diet adequate in macronutrients is crucial for the secondary prevention of cardiovascular diseases. Objective: To assess the prevalence of adherence to recommendations for the consumption of dietary fatty acids for the prevention and treatment of cardiovascular diseases and to estimate whether the presence of certain cardiovascular risk factors would be associated with adherence. Methods: Cross-sectional study using baseline data from 2,358 participants included in the "Brazilian Cardioprotective Nutritional Program Trial". Dietary intake and cardiovascular risk factors were assessed. Adequate intake of polyunsaturated fatty acids (PUFA) was considered as ≥10% of total daily energy intake; for monounsaturated fatty acids (MUFA), 20%; and for saturated fatty acids (SFA), <7% according to the Brazilian Society of Cardiology. A significance level of 5% was considered in the statistical analysis. Results: No participant adhered to all recommendations simultaneously, and more than half (1,482 [62.9%]) did not adhere to any recommendation. Adherence exclusively to the SFA recommendation was the most prevalent, fulfilled by 659 (28%) participants, followed by adherence exclusively to the PUFA (178 [7.6%]) and MUFA (5 [0.2%]) recommendations. There was no association between the number of comorbidities and adherence to nutritional recommendations (p = 0.269). Participants from the Brazilian Northeast region showed a higher proportion of adherence to SFA consumption recommendations (38.42%) and lower adherence to PUFA intake (3.52%) (p <0.001) compared to other regions. Conclusions: Among the evaluated sample, there was low adherence to nutritional recommendations for dietary fatty acid consumption. Background Objective Methods Crosssectional Cross sectional 2358 2 358 2,35 Trial. Trial . Trial" assessed (PUFA 10 ≥10 MUFA, , (MUFA) 20% 20 SFA, (SFA) 7 <7 Cardiology 5 analysis Results simultaneously 1,482 1482 1 482 (1,48 62.9% 629 62 9 [62.9%] prevalent 65 28% 28 (28% 178 (17 7.6% 76 6 [7.6%] ( 0.2% 02 0 [0.2%] p 0.269. 0269 0.269 269 0.269) 38.42% 3842 38 42 (38.42% 3.52% 352 3 52 (3.52% <0.001 0001 001 regions Conclusions sample 235 35 2,3 ≥1 (MUFA (SFA < 1,48 148 48 (1,4 62.9 [62.9% (28 17 (1 7.6 [7.6% 0.2 [0.2% 026 0.26 26 38.42 384 4 (38.42 3.52 (3.52 <0.00 000 00 23 2, ≥ 1,4 14 (1, 62. [62.9 (2 7. [7.6 0. [0.2 38.4 (38.4 3.5 (3.5 <0.0 1, [62. [7. [0. 38. (38. 3. (3. <0. [62 [7 [0 (38 (3 <0 [6 [

https://doi.org/10.36660/abc.20230487

Streptococcus suis meningitis: An emerging zoonotic disease in Brazil meningitis
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Ramos, Geisa Santos Souza

; Rego, Renata Ferreira da Silva

; Oliveira, Maria Fernanda Feltrin de

; Rocha, Verônica de França Diniz

; Oliveira, Ernesto Pereira de

; Reis, Joice Neves

Revista da Sociedade Brasileira de Medicina Tropical

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2024, Volume 57 elocation e00805-2024

Abstract: En | Text: En | PDF: En

ABSTRACT Streptococcus suis has been widely reported as a pathogen in animals, especially pigs. In terms of human health implications, it has been characterized as a zoonosis associated with the consumption of pork products and occupational exposure, particularly in Southeast Asian countries. Here, we present a rare case of human S. suis infection in Brazil, diagnosed in an older adult swine farmer, a small rural producer residing in the semi-arid region of Bahia, Brazil. animals pigs implications exposure countries Here S Brazil farmer semiarid semi arid Bahia

https://doi.org/10.1590/0037-8682-0610-2023

10.

MEMÓRIA E ANCORAGEM NA CONSTRUÇÃO DE REPRESENTAÇÕES SOCIAIS SOBRE EDIÇÃO GENÉTICA DE EMBRIÕES HUMANOS
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Eskinazi, Renan Harmes

; Aléssio, Renata Lira dos Santos

; Santos, Maria de Fátima de Souza

Psicologia & Sociedade

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2024, Volume 36 elocation e278088

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo: As representações sociais são elaboradas a partir da inserção de determinado objeto em um sistema de conhecimentos preexistentes, processo este, denominado de ancoragem. Este estudo buscou analisar a relação entre memória e ancoragem nas representações sociais da edição genética de embriões humanos. Foram conduzidas 40 entrevistas com pessoas adultas maiores de 18 anos sobre opiniões acerca da edição genética de embriões humanos. Realizou-se uma Análise de Conteúdo Temática a partir das entrevistas. As memórias evocadas discutem os avanços da ciência e o surgimento de outras biotecnologias no passado. O risco de práticas eugenistas e erros da ciência também foram rememorados. As memórias mostram duas tendências concomitantes entre os entrevistados: a busca pela familiarização da edição genética e/ou o distanciamento deste objeto. Os posicionamentos revelam um pensamento condicional, apontando para os aspectos controversos e esperançosos e as consequências positivas e negativas que podem ocorrer a partir da aplicação dessa tecnologia. Resumo preexistentes este humanos 4 1 Realizouse Realizou se passado rememorados entrevistados eou ou condicional tecnologia

Abstract: Social representations are developed by inserting a given object into a system of preexisting knowledge, a process known as anchoring. This study sought to analyze the relationship between memory and anchoring in social representations of human embryo genetic editing. Forty interviews were conducted with adults over 18 years of age about their opinions about human embryo genetic editing. A Thematic Content Analysis was carried out based on the interviews. The memories evoked discuss scientific advances and the emergence of other biotechnologies in the past. The risk of eugenic practices and scientific errors were also recalled. The memories show two concomitant trends among the interviewees: the search for familiarization with genetic editing and/or distancing from this object. The positions reveal conditional thinking, pointing to the controversial and hopeful aspects and the positive and negative consequences that may occur from the application of this technology. Abstract knowledge 1 past recalled interviewees andor or thinking technology

Resumen: Las representaciones sociales se crean a partir de la inserción de un determinado objeto en un sistema de conocimientos preexistentes, proceso llamado anclaje. Este estudio buscó analizar la relación entre la memoria y anclaje en las representaciones sociales de la edición genética de embriones humanos. Se realizaron 40 entrevistas a adultos mayores de 18 años sobre sus opiniones acerca de la edición genética de embriones humanos. Se realizó un análisis de contenido temático a partir de las entrevistas. Las memorias evocadas discuten los avances de la ciencia e el surgimiento de otras biotecnologías en el pasado. También se recordó el riesgo de prácticas eugenésicas y de errores en la ciencia. Las memorias muestran dos tendencias concomitantes entre los entrevistados: la búsqueda de familiarización con la edición genética y/o el distanciamiento de ese objeto. Las posturas revelan un pensamiento condicional, señalando los aspectos controvertidos y esperanzadores y las consecuencias positivas y negativas que pueden surgir del uso de esta tecnología. Resumen preexistentes humanos 4 1 pasado entrevistados yo o condicional tecnología

https://doi.org/10.1590/1807-0310/2024v36278088

11.

[SciELO Preprints] - What is the influence of lifestyle habits and socioeconomic factors on the occurrence of prostate cancer in Brazil?
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Souza, Marco Antonio de Monteiro, Camila Nascimento Barros, Cláudia Renata dos Santos

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Publication date: 2023-12-08

Abstract: En Es Pt

Objective: the investigation of physical, lifestyle and socioeconomic features that may be associated with the occurrence of prostate cancer in Brazil. Methods: a microdata base referring to the 2019 National Health Survey in Brazil was used, with the selection of 42,799 male individuals; this group was analyzed using statistical methods and machine learning modeling (logistic regression and decision tree). Results: the models applied allowed us to identify with a good level of accuracy individuals with prostate cancer diagnosis (DCP), in addition to groups with specific features more strongly associated with such a disease. Conclusion: the models indicate a significant influence of socioeconomic, physical and dietary factors on the frequency of DCP in the analyzed group. The high level of accuracy and sensitivity of the models demonstrates the potential of machine learning methods for predicting DCP.

Objetivo: investigar características físicas, de estilo de vida y socioeconómicas que pueden estar asociadas con la aparición de cáncer de próstata en Brasil. Métodos: se utilizó una base de microdatos referente a la Encuesta Nacional de Salud de 2019, con la selección de 42.799 individuos del sexo masculino; este grupo fue analizado mediante métodos estadísticos y modelado de machine learning (regresión logística y árbol de decisión). Resultados: los modelos aplicados permitieron identificar con buen nivel de exactitud a los individuos con diagnóstico de cáncer de próstata (DCP), además de grupos con características específicas más fuertemente asociadas a esta enfermedad. Conclusión: los modelos indican influencia significativa de factores socioeconómicos, físicos y dietéticos sobre la frecuencia de DCP en el grupo analizado. El alto nivel de exactitud y sensibilidad de los modelos demuestra el potencial de los métodos de machine learning para predecir la DCP.

Objetivo: investigar características físicas, de hábitos de vida e socioeconômicas que podem estar associadas à ocorrência de câncer de próstata no Brasil. Métodos: uma base de microdados referente à Pesquisa Nacional de Saúde 2019 foi utilizada, com a seleção de 42.799 indivíduos do sexo masculino; este grupo foi analisado por meio de métodos estatísticos e modelagem por machine learning (regressão logística e árvore de decisão). Resultados: os modelos aplicados permitiram identificar com bom nível de acurácia os indivíduos que receberam o diagnóstico de câncer de próstata (DCP), além de grupos com características específicas mais fortemente associados a esta doença. Conclusão: os modelos indicam uma influência significativa de fatores socioeconômicos, físicos e alimentares na frequência de DCP no grupo analisado. O alto nível de acurácia e sensibilidade dos modelos demonstra o potencial dos métodos de machine learning para a previsão de DCP.

https://doi.org/10.1590/SciELOPreprints.7566

12.

COVID-Inconfidentes - SARS-CoV-2 seroprevalence in two Brazilian urban areas in the fourth quarter 2020: study protocol and initial results
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Meireles, Adriana Lúcia

; Garcia Lourenção, Luciano

; Alves de Menezes Júnior, Luiz Antônio

; Nascimento Coletro, Hillary

; Sousa Justiniano, Irene Carolina

; Silva de Moura, Samara

; Popolino Diniz, Amanda

; da Silva Sabião, Thaís

; Sampaio Rocha, Ana Maria

; Batista, Aline Priscila

; Nunes Lage, Nara

; dos Santos Simões, Bárbara

; Ali Santos, Carolina

; de Deus Mendonça, Raquel

; de Souza Andrade, Amanda Cristina

; Furbino Barbosa, Keila

; Zumerle Masioli, Cássio

; Cardoso Carraro, Júlia Cristina

; Carvalho de Menezes, Mariana

; Rezende Macedo Nascimento, Renata Cristina

; Roever, Leonardo

; Teixeira Caiaffa, Waleska

; Lins Machado Coelho, George Luiz

Población y Salud en Mesoamérica

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dec 2023, Volume 21 N. 1 Pages 15 - 37

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Objective: To describe study protocol and initial results of research project COVID-Inconfidentes. Method: This paper described the methodological procedures adopted and the prevalence of the SARS-CoV-2 infection in the population. A household survey was conducted between October and December 2020, in two historic cities of Brazil's mining region. Anti-SARS-CoV-2 antibody was detected using the Wondfo® rapid test. The face-to face interview consisted of administration of a questionnaire containing registration data, sociodemographic and economic variables, living habits, general health condition, mental health, sleep habits, and eating and nutrition. Results: We evaluated 1,762 residents, of which 764 (43.4 %) were in Mariana and 998 (56.6 %) in Ouro Preto. For both cities, 51.9 % of the interviewees were female, with a predominance of the age range 35 to 59 years old (47.2 %). The prevalence of the SARS-CoV-2 infection was 5.5 % in both cities, 6.2 % in Ouro Preto, and 4.7 % in Mariana (p-value > 0.05). Conclusion: The study was effective to estimate the seroprevalence of infection by the virus and its findings will enable further analyses of the health conditions of the population related to social isolation and the risk of infection with SARS-CoV-2.

Resumen Describir el protocolo de estudio y los resultados iniciales del proyecto de investigación COVID Inconfidentes. Método: Este artículo describe los procedimientos metodológicos adoptados y la prevalencia de la infección por SARS-CoV-2 en la población. Se realizó una encuesta domiciliaria entre octubre y diciembre de 2020, en dos ciudades históricas de la región minera de Brasil. El anticuerpo anti-SARS-CoV-2 se detectó mediante la prueba rápida Wondfo®. La entrevista cara a cara consistió en la administración de un cuestionario que contenía datos de registro, variables sociodemográficas y económicas, hábitos de vida, estado general de salud, salud mental, hábitos de sueño, alimentación y nutrición. Resultados: Se evaluaron 1.762 habitantes, de los cuales 764 (43,4 %) estaban en Mariana y 998 (56,6 %) en Ouro Preto. Para ambas ciudades, el 51,9 % de los entrevistados eran del sexo femenino, con predominio del rango de edad de 35 a 59 años (47,2 %). La prevalencia de la infección por SARS-CoV-2 fue del 5,5 % en ambos municipios, del 6,2 % en Ouro Preto y del 4,7 % en Mariana (p > 0,05). Conclusión: El estudio fue efectivo para estimar la seroprevalencia de infección por el virus y sus hallazgos permitirán analizar más las condiciones de salud de la población relacionadas con el aislamiento social y el riesgo de infección por SARS-CoV-2.

https://doi.org/10.15517/psm.v21i1.53127

13.

Reply to the letter regarding the article entitled: “Access to rehabilitation after stroke in Brazil (AReA study): multicenter study protocol” entitled Access AReA study) protocol
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Cacho, Roberta de Oliveira

; Moro, Carla Heloisa Cabral

; Bazan, Rodrigo

; Guarda, Suzete Nascimento Farias da

; Pinto, Elen Beatriz

; Andrade, Suellen Mary Marinho dos Santos

; Valler, Lenise

; Almeida, Kelson James

; Ribeiro, Tatiana Souza

; Jucá, Renata Viana Brígido de Moura

; Minelli, Cesar

; Piemonte, Maria Elisa Pimentel

; Paschoal, Eric Homero Albuquerque

; Pedatella, Marco Túlio Araújo

; Pontes-Neto, Octávio Marques

; Fontana, Ana Paula

; Pagnussat, Aline de Souza

; Conforto, Adriana Bastos

Arquivos de Neuro-Psiquiatria

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jul 2023, Volume 81 N. 7 Pages 703 - 704

Abstract: En | Text: En | PDF: En

https://doi.org/10.1055/s-0043-1771266

14.

Increased expression of matrix metalloproteinases 2 and 9 as poor prognosis factor for Hodgkin’s lymphoma patients Hodgkins Hodgkin s
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Silva, Bárbara de Oliveira

; Medeiros, Jonathan Wagner

; Albuquerque, Giwellington Silva

; Valderrama, Pavel Medina

; Barbosa, Athos Henrique de Quevedo

; Souza, Juliana Maria de

; Oliveira, Renata Santos

; Morais, Adriana Lins

; Silva Neto, Jacinto da Costa

; Muniz, Maria Tereza Cartaxo

Jornal de Pediatria

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jan 2023, Volume 99 N. 1 Pages 59 - 64

Abstract: En | Text: En | PDF: En

Abstract Objective: The aim of our study was to evaluate the expression of MMP-2 and MMP-9 as a prognostic factor in patients diagnosed with Hodgkin Lymphoma (HL). Methods: In the present study, 45 paraffin biopsies from patients up to 19 years old diagnosed with HL were used in two referral hospitals in the state of Pernambuco, Brazil. Risk groups were classified into favorable and unfavorable, according to Ann Arbor. The expression of matrix metalloproteinases 2 and 9 and their inhibitors was performed by immunohistochemistry (IHC). Data were analyzed using the GraphPad Prism 5 program. Results: MMP-2 intensity pattern was stronger (> 10% of the total field) in patients with stage III/ IV and B symptoms. MMP-2 showed an association with the risk group (p = 0.0388). That is, the stronger the MMP-2 marking, the greater the unfavorable risk. However, for MMP-9 there was no difference in the stronger intensity pattern in relation to stages I/II and III/IV, only in the presence of B symptoms. MMP-9 showed an association with B Symptoms (p = 0.0411). Therefore, patients with B symptoms have higher MMP-9 expression. Conclusion: Our results suggest that MMP-2 expression is associated with HL progression. While MMP-9 expression is related to the clinical worsening of these patients. However, further studies are needed to evaluate the exact role of these proteins in hematologic malignancies. Objective MMP2 MMP MMP- MMP9 HL. . (HL) Methods 4 1 Pernambuco Brazil Arbor IHC. IHC (IHC) program Results > ( 10 field III p 0.0388. 00388 0.0388 0 0388 0.0388) marking However I II IIIIV III/IV 0.0411. 00411 0.0411 0411 0.0411) Therefore Conclusion progression malignancies (HL (IHC 0038 0.038 038 0041 0.041 041 003 0.03 03 004 0.04 04 00 0.0 0.

https://doi.org/10.1016/j.jped.2022.05.004

15.

Reproductive behavior of Pantaneiros sheep, Mato Grosso do Sul, Brazil
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Martins, Charles Ferreira

; Santiago Filho, Arnaldo

; Ferreira, Marcos Barbosa

; Fernandes, Carlos Eurico dos Santos

; Monreal, Antonio Carlos Duenhas

; Souza, Carla Giselly de

; Chagas, Renata Alves das

; Vargas Junior, Fernando Miranda de

Acta Scientiarum. Animal Sciences

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2023, Volume 45 elocation e57518

Abstract: En | Text: En | PDF: En

ABSTRACT. The objective was to evaluate fertility, cyclicality behavior, and sexual performance of Pantaneiro sheep throughout the year’s photoperiods in Mato Grosso do Sul - Brazil. Two experiments were conducted. In experiment one, the ewes used aged between 2 and 4 years, distributed in three homogeneous groups of 54 animals and subjected to reproductive evaluation in three different predefined luminosity periods, consisting of autumn (11h 45 min.), spring (12h 30 min.), and summer (12h 55 min.). The characteristics studied were body weight (BW), body condition score (BCC), estrus distribution (EST), percentage of pregnant females per cycle (%P), plasma progesterone (PP), and fertility (F) in the three predefined seasons. The mating system used was controlled natural nocturnal and lasted for 45 days. Experiment two, evaluated the ram sexual activity. The males (10) were individually exposed to four ovariectomized ewes. The ewes cycled during evaluated seasons, and the highest fertility was observed in animals with BCC >2.75. The PP concentration differed among periods, and higher conception rates (F) were observed in autumn and spring. The rams (75%) had a medium of sexual performance when they performed more than two ejaculations in 20 min throughout the seasons. Pantaneiro sheep of both genders had a similar fertility index, with early and constant activity throughout the year, displaying no photoperiodism or seasonality.

https://doi.org/10.4025/actascianimsci.v45i1.57518

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