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Resumo A glomerulopatia colapsante (GC) apresenta um curso grave, tipicamente associado a infecções virais, especialmente HIV e parvovírus B19, lúpus eritematoso sistêmico (LES), entre outras etiologias. Uma mulher de 35 anos, com uso recente de um inibidor de JAK devido à artrite reumatoide, apresentou histórico de duas semanas de febre, adenopatia cervical e eritema facial. Após a admissão, observou-se anemia, hipoalbuminemia, proteinúria e injúria renal aguda grave. Foi diagnosticado LES e o DNA do parvovírus B19 foi detectado em amostras de soro. A biópsia renal revelou GC sem quaisquer características típicas de nefrite lúpica. A paciente foi tratada com prednisona e apresentou melhora acentuada da anemia e da função renal após algumas semanas. Neste caso, a paciente com LES apresentou GC possivelmente causada por infecção por parvovírus B19 associada ao genótipo homozigoto G1 da apolipoproteína 1 (APOL1), que tem sido descrito como um fator de risco determinante para essa glomerulopatia. Não está claro se o LES teve uma relação causal com a doença glomerular ou se foi uma causa concomitante. O tratamento pode ser desafiador nesse contexto, uma vez que nenhum medicamento antiviral é eficaz e a imunossupressão não apresenta benefícios perceptíveis, embora o uso de esteroides tenha sido eficaz no tratamento das manifestações renais nesse caso.

Abstract Collapsing glomerulopathy (CG) has a severe course typically associated with viral infections, especially HIV and parvovirus B19, systemic lupus erythematosus (SLE), among other etiologies. A 35-year-old woman with recent use of a JAK inhibitor due to rheumatoid arthritis presented with a 2-week history of fever, cervical adenopathy, and facial erythema. After admission, anemia, hypoalbuminemia, proteinuria, and severe acute kidney injury were noted. SLE was diagnosed and parvovirus B19 DNA was detected in serum samples. Kidney biopsy showed CG without any typical features of lupus nephritis. The patient was treated with prednisone and presented marked improvement of anemia and kidney function after a few weeks. In this case, the patient with SLE presented CG possibly caused by parvovirus B19 infection associated with homozygous apolipoprotein 1 (APOL1) G1 genotype, which has been described as a determinant risk factor for this glomerulopathy. It is not clear whether SLE had a causal relationship with glomerular disease or was a concurrent cause. Treatment can be challenging in such a context, as no antiviral drug is efficient and immunosuppression has no discernable benefit, although steroid use was efficient in treating renal manifestations in this case.

https://doi.org/10.1590/2175-8239-jbn-2024-0104en

Atenção nutricional no enfrentamento da obesidade na Atenção Primária à Saúde: proposta de modelo avaliativo
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Souza, Rafaela

; Lacerda, Josimari Telino de

; Machado, Patrícia Maria de Oliveira

Saúde em Debate

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mar 2025, Volume 49 N. 144 elocation e9435

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT The article aims to propose an evaluative model for nutritional care to address obesity in Primary Health Care. It is based on the model proposed by Machado and Lacerda for evaluating Nutritional Care. Official documents and scientific articles related to the subject were analyzed, and input from a group of stakeholders guided the development of the Theoretical Model, Logical Model, and the Analysis and Judgment Matrix. To validate the evaluative model, a consensus conference technique was used, involving 11 experts in the fields of nutrition and health evaluation. The matrix consists of twenty-four indicators and sixty measures, organized into seven subdimensions and two dimensions: Management and Care. The evaluative model operates on the assumption that municipal management bears the responsibility of providing the necessary structural and organizational conditions for the implementation of nutrition and food-related actions to combat obesity in an intersectoral, multiprofessional, and interdisciplinary manner, following the principles of comprehensive Primary Health Care.

RESUMO O artigo tem como objetivo apresentar uma proposta de modelo avaliativo da atenção nutricional para o enfrentamento da obesidade na Atenção Primária à Saúde. Utilizou como base o modelo proposto por Machado e Lacerda para avaliar a atenção nutricional. Foram analisados documentos oficiais e artigos científicos relacionados ao tema, além da consulta a um grupo de interessados que orientaram a elaboração do Modelo Teórico, Modelo Lógico e da Matriz de Análise e Julgamento. Para a validação do modelo avaliativo foi utilizada a técnica de conferência de consenso com 11 especialistas na área de nutrição e avaliação em saúde. A matriz é composta por vinte e quatro indicadores e sessenta medidas, organizadas em sete subdimensões e duas dimensões: Gestão e Assistência. O modelo avaliativo parte do pressuposto da responsabilidade da gestão municipal em fornecer condições estruturais e organizacionais necessárias para a execução das ações de Alimentação e Nutrição para o enfrentamento da obesidade de forma intersetorial, multiprofissional e interdisciplinar, seguindo os preceitos da Atenção Primária à Saúde abrangente.

https://doi.org/10.1590/2358-289820251449435p

Safety of two-dose schedule of COVID-19 adsorbed inactivated vaccine (CoronaVac; Sinovac/Butantan) and heterologous additional doses of mRNA BNT162b2 (Pfizer/BioNTech) in immunocompromised and immunocompetent individuals
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Miyaji, Karina Takesaki

; Ibrahim, Karim Yaqub

; Infante, Vanessa

; Moreira, Raquel Megale

; Santos, Carolina Ferreira dos Belizário, Juliana de Cássia Pinto, Maria Isabel de Moraes Marinho, Ana Karolina Barreto Berselli Pereira, Juliana Marquezi Mello, Liliane Saraiva de Silva, Vitor Gabriel Lopes da Sato, Paula Keiko Strabelli, Tânia Mara Varejão Ragiotto, Lucas Pacheco, Pedro Henrique Theotonio de Mesquita Braga, Patricia Emilia Loch, Ana Paula Precioso, Alexander Roberto Sartori, Ana Marli Christovam França, João Ítalo Lima, Marcos Alves de Ando, Mauricio Cesar Sampaio Rodrigues, Camila Cristina Martini Song, Alice Tung Wan Lara, Amanda Nazareth Belizário, Ana Cristina Lima, Anna Helena Simões Bortulucci de Zanetti, Ariane Cristina Barboza Paulo, Audrey Rose da Silveira Amancio de Rosa, Barbara Miranda dos Santos Moraes, Bruna Del Guerra de Carvalho Oliveira, Bruna Ribeiro de Picone, Camila de Melo Aranda, Carolina Sanches Troli, Carolinne Paioli Kokron, Cristina M. Terrabuio, Debora Raquel Benedita Abdala, Edson David Neto, Elias Nakanishi, Érika Yoshie Shimoda Lima, Fabiana Mascarenhas Souza Firmino, Fabio Batista Santos, Fernanda Barone Alves dos Bacal, Fernando Fatobene, Giancarlo Santana, Jaqueline Oliveira Kalil, Jorge Barbosa, Julia Gonçalves, Leandro Peres Otuyama, Leonardo Jun Pierrotti, Ligia Camera Compte, Livia Caroline Mariano Marinho, Livia Chaer, Livia Netto Seguro, Luis Fernando Azevedo, Luiz Sergio Ueda, Márcia Aiko Terreri, Maria Teresa Barros, Myrthes Anna Maragna Toledo Grecco, Octávio Sejas, Odeli Nicole Encinas Musqueira, Priscila Tavares Ito, Raquel Keiko de Luca Teixeira, Samia Silveira Souza Fidalgo, Serafim Costa, Silvia Figueiredo Campos, Silvia Vidal Fernandes, Tamiris Hinsching Rocha, Vanderson Geraldo Coelho, Vivian Caso

Revista do Instituto de Medicina Tropical de São Paulo

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2025, Volume 67 elocation e2

Abstract: En | Text: En | PDF: En

ABSTRACT Immunocompromised individuals were considered high-risk for severe disease due to SARS COV-2 infection. This study aimed to describe the safety of two doses of COVID-19 adsorbed inactivated vaccine (CoronaVac; Sinovac/Butantan), followed by additional doses of mRNA BNT162b2 (Pfizer/BioNTech) in immunocompromised (IC) adults, compared to immunocompetent/healthy (H) individuals. This phase 4, multicenter, open label study included solid organ transplant and hematopoietic stem cell transplant recipients, cancer patients and people with inborn errors of immunity with defects in antibody production, rheumatic, end-stage chronic kidney or liver disease, who were enrolled in the IC group. Participants received two doses of CoronaVac and additional doses of mRNA BNT162b2. Adverse reactions (AR) data were collected within seven days after each vaccination. Serious adverse events and of special interest (AESI) were monitored throughout the study. We included 241 immunocompromised and 100 immunocompetent subjects. Arthralgia, fatigue, myalgia, and nausea were more frequent in the IC group after CoronaVac. Following the first additional dose of mRNA BNT162, pain, induration, and tenderness at injection site, fatigue and myalgia were more frequent in the H group. A heart transplant recipient had a graft rejection temporally associated with the second CoronaVac dose, but there was no literature evidence of causal association. Four cases of AESI were considered related to the vaccine: three erythema multiforme after CoronaVac, all in IC participants, and one paresthesia after mRNA, in a H participant. Our findings were comparable to other studies that evaluated the safety of COVID-19 vaccines in different immunocompromised populations. Both vaccines were safe for immunocompromised participants.

https://doi.org/10.1590/s1678-9946202567002

Agronomic performance of ‘BRS Cora’ grapevines grown under different training systems, rootstocks and growing seasons in a semi-arid region
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Leão, Patrícia Coelho de Souza

; Oliveira, Carlos Roberto Silva de

Bragantia

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2025, Volume 84 elocation e20240167

Abstract: En | Text: En | PDF: En

ABSTRACT Producing grapes for juice has been gaining prominence in the Northeast region of Brazil with diversification of grape cultivars for juice production over the past decade. The aim of this study was to estimate the effect of different vine training systems and rootstocks on the vigor, yield, and morpho-agronomic traits of ‘BRS Cora’ grapes over six production cycles. The experiment was conducted in Petrolina, PE, Brazil, from 2017 to 2020. A randomized block experimental design was used with four replications in split-split plots in time, with evaluation of the espalier, pergola, and lyre training systems combined with the rootstocks IAC 572 and IAC 766. The variables studied were the following: bud fertility index; yield per plant; number of clusters per plant; weight, width and length of cluster and berry; soluble solids (SS); titratable acidity (TA); and ratio SS/TA. The response of the ‘BRS Cora’ vines were different depending on the training system, rootstock, production cycle, or interaction among them. The bud fertility index varied only as a result of the production cycle. The pergola training system increased yield in relation to espalier and lyre systems, also favoring a larger number and size of clusters. The IAC 766 rootstock increased berry size and TA, whereas IAC 572 favored higher sugar/SS content and SS/TA ratio. The fourth production cycle (harvest on 9 May 2019) led to the best agronomic performance of ‘BRS Cora’ grapevines under the conditions of the Submédio do Vale do São Francisco region.

https://doi.org/10.1590/1678-4499.20240167

Joint statement on evidence-based practices in mechanical ventilation: suggestions from two Brazilian medical societies
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Ferreira, Juliana Carvalho

; Vianna, Arthur Oswaldo de Abreu

; Pinheiro, Bruno Valle

; Maia, Israel Silva

; Baldisserotto, Sérgio Vasconcellos

; Isola, Alexandre Marini

; Cavalcanti, Alexandre Biasi Gama, Ana Maria Casati Nogueira da Rocha, Angelo Roncalli Miranda Oliveira, Antonio Gonçalves de Serpa Neto, Ary Farias, Augusto Manoel de Carvalho Orlando, Bianca Rodrigues Esteves, Bruno da Costa Mazza, Bruno Franco Silveira, Camila de Freitas Martins Soares Carvalho, Carlos Roberto Ribeiro de Toufen Junior, Carlos Barbas, Carmen Silvia Valente Teixeira, Cassiano Silveira, Débora Dutra da Medeiros, Denise Machado Parolo, Edino Costa, Eduardo Leite Vieira Caser, Eliana Bernadete Oliveira, Ellen Pierre de Banholzer, Eric Grieger Carvalho, Erich Vidal Amorim, Fabio Ferreira Saddy, Felipe Gonçalves, Fernanda Alves Ferreira Galas, Filomena Regina Barbosa Gomes Zanatta, Giovanna Carolina Gardini Silva, Gisele Sampaio Westphal, Glauco Adrieno Matos, Gustavo Faissol Janot de Souza, João Claudio Emmerich de Silva Junior, João Manoel Valiatti, Jorge Luis dos Santos Nascimento Junior, José Ribamar do Rocco, Jose Rodolfo Hajjar, Ludhmila Abrahão Forgiarini Junior, Luiz Alberto Malbuisson, Luiz Marcelo Sá Holanda, Marcelo Alcantara Amato, Marcelo Britto Passos Park, Marcelo Oliveira, Marco Antonio da Rosa e Reis, Marco Antonio Soares Tavares, Marcos Soares Souza, Mario Henrique Dutra de Damasceno, Marta Cristina Pauleti Lira-Batista, Marta Maria da Silva Pattacini, Max Morais Assunção, Murillo Santucci Cesar de Oliveira, Neymar Elias de Franzosi, Oellen Stuani Rocco, Patricia Rieken Macedo Caruso, Pedro Silva, Pedro Leme Mendes, Pedro Vitale Duarte, Pericles Almeida Delfino Santa Neto, Renato Fabio Alberto Della Rodrigues, Ricardo Goulart Cordioli, Ricardo Luiz Palazzo, Roberta Fittipaldi Goldwasser, Rosane Pinheiro, Sabrina dos Santos Justino, Sandra Regina Nemer, Sergio Nogueira Oliveira, Vanessa Martins de Silva, Vinicius Zacarias Maldaner da Nedel, Wagner Luis Bellissimo-Rodrigues, Wanessa Teixeira Oliveira Filho, Wilson de

Critical Care Science

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2025, Volume 37 elocation e20250242en

Abstract: En | Text: En | PDF: En

ABSTRACT Mechanical ventilation can be a life-saving intervention, but its implementation requires a multidisciplinary approach, with an understanding of its indications and contraindications due to the potential for complications. The management of mechanical ventilation should be part of the curricula during clinical training; however, trainees and practicing professionals frequently report low confidence in managing mechanical ventilation, often seeking additional sources of knowledge. Review articles, consensus statements and clinical practice guidelines have become important sources of guidance in mechanical ventilation, and although clinical practice guidelines offer rigorously developed recommendations, they take a long time to develop and can address only a limited number of clinical questions. The Associação de Medicina Intensiva Brasileira and the Sociedade Brasileira de Pneumologia e Tisiologia sponsored the development of a joint statement addressing all aspects of mechanical ventilation, which was divided into 38 topics. Seventy-five experts from all regions of Brazil worked in pairs to perform scoping reviews, searching for publications on their specific topic of mechanical ventilation in the last 20 years in the highest impact factor journals in the areas of intensive care, pulmonology, and anesthesiology. Each pair produced suggestions and considerations on their topics, which were presented to the entire group in a plenary session for modification when necessary and approval. The result was a comprehensive document encompassing all aspects of mechanical ventilation to provide guidance at the bedside. In this article, we report the methodology used to produce the document and highlight the most important suggestions and considerations of the document, which has been made available to the public in Portuguese.

https://doi.org/10.62675/2965-2774.20250242-en

Factors associated with the dietary total antioxidant capacity of pregnant Brazilian women
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Carvalho, Roberta Rejane Santos de

; Viola, Poliana Cristina de Almeida Fonseca

; Crispim, Sandra Patrícia

; França, Ana Karina Teixeira da Cunha

; Navarro, Anderson Marliere

; Souza, Bruno Feres de

; Faria, Franciane Rocha de

; Sperandio, Naiara

; Pizato, Nathalia

; Macedo, Mariana de Souza

; Pereira, Renata Junqueira

; Franceschini, Sylvia do Carmo Castro

; Carvalho, Carolina Abreu de

; Navarro, Anderson Marliere

; Carvalho, Carolina Abreu de

; Silva, Danielle Góes da

; Faria, Franciane Rocha de

; Sperandio, Naiara

; Meléndez, Jorge Gustavo Velásquez

; Barbosa, Míriam do Carmo Rodrigues

; Pizato, Nathalia

; Macedo, Mariana de Souza

; Pereira, Renata Junqueira

; Crispim, Sandra Patrícia

; Priore, Silvia Eloiza

; Franceschini, Sylvia do Carmo Castro

Revista Brasileira de Epidemiologia

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2025, Volume 28 elocation e250002

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Investigar os fatores sociodemográficos, maternos e gestacionais associados à capacidade antioxidante total da dieta em gestantes brasileiras. Métodos: Estudo transversal com 2.232 gestantes com 18 anos ou mais, no primeiro, segundo e terceiro trimestres de gestação de onze cidades das cinco regiões brasileiras. Foi aplicado um questionário semiestruturado para avaliação dos dados socioeconômicos, demográficos e de saúde, e o recordatório de 24h (R24h) para avaliação do consumo alimentar e análise da Capacidade Antioxidante Total da Dieta (CATd), estimada usando o método Ferric Reducing Antioxidant Power (FRAP). Resultados: A mediana de CATd foi de 5,32 mmol/dia. Aracaju (SE) apresentou a maior mediana de CATd (6,44 mmol/dia) e Palmas (TO) a menor (4,71 mmol/dia). As gestantes de 20 a 34 anos (OR 1,86; IC95% 1,26-2,76), 35 anos ou mais (OR 3,68; IC95% 2,21-6,14) e que estavam no segundo trimestre de gestação (OR 1,50; IC95%; 1,11-2,01) tiveram mais chances de estarem acima da mediana de CATd, enquanto as gestantes com maior escolaridade tinham 67% menos chance de estarem acima da mediana de CATd (OR 0,67; IC95% 0,48-0,92). Conclusão: O estudo demonstrou que há diferenças no consumo de antioxidantes em diferentes cidades do Brasil e que fatores associados, como idade, escolaridade e trimestre gestacional podem impactar na ingestão de alimentos ricos em antioxidantes. O perfil encontrado chama atenção para a importância de uma alimentação adequada e rica em antioxidantes durante o pré-natal.

ABSTRACT Objective: To investigate the sociodemographic, maternal, and gestational factors associated with the dietary total antioxidant capacity in pregnant Brazilian women. Methods: A cross-sectional study with 2,232 pregnant women aged 18 years old or older, in the first, second, and third trimesters of pregnancy, from eleven cities in the five Brazilian regions. A semi-structured questionnaire was applied to assess socioeconomic, demographic, and health data, and a 24-hour dietary recall (R24h) was used to assess food consumption and analyze the dietary total antioxidant capacity (DTAC), estimated using the ferric reducing antioxidant power (FRAP) method. Results: The median of DTAC was 5.32 mmol/day. Aracaju, Sergipe (SE) had the highest median of DTAC (6.44 mmol/day) and Palmas, Tocantins (TO) had the lowest (4.71 mmol/day). Pregnant women aged 20 to 34 years (OR 1.86; 95%CI 1.26-2.76), 35 years old or older (OR 3.68; 95%CI 2.21-6.14) and who were in the second trimester of pregnancy (OR 1.50; 95%CI 1.11-2.01) were more likely to be above the median DTAC. While pregnant women with higher education had a 67% lower chance of being above the median DTAC (OR 0.67; 95%CI 0.48-0.92). Conclusion: The study demonstrated that there are differences in antioxidant consumption in different cities in Brazil and that associated factors such as age, education, and gestational trimester can impact the intake of foods rich in antioxidants. The profile found draws attention to the importance of an adequate diet rich in antioxidants during prenatal care.

https://doi.org/10.1590/1980-549720250002

Effects of iron and copper on emergence and physiology of Canavalia ensiformis (l.) DC l. l (l. (l
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Carvalho, Isabella F. de

; Alves, Patrícia B.

; Ferreira, Tássia C.

; Santos, Beatriz S. dos

; Cozin, Bruno B.

; Souza, Roberta P. de

; Camargos, Liliane S.

Revista Caatinga

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2025, Volume 38 elocation e12686

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO As plantas necessitam de ferro (Fe) e cobre (Cu) em baixas concentrações para realizar funções metabólicas. Porém, o excesso de Fe e Cu no solo pode causar toxicidade e afetar o desenvolvimento das plantas. O objetivo desse estudo foi avaliar os efeitos das concentrações de Cu e Fe no solo na emergência das plântulas, bem como no metabolismo dos principais compostos de reserva e na biomassa de raízes, caules, folhas e cotilédones de Canavalia ensiformis. O experimento foi conduzido em casa de vegetação, em delineamento inteiramente casualizado; os tratamentos de Cu e Fe no solo foram: (controle, 50, 150, 250 e 350 mg dm-3) durante um período de 10 dias. A emergência das plântulas não foi afetada pelos tratamentos avaliados; entretanto, os resultados mostraram aumento do índice de velocidade de emergência (EVI) para o tratamento com Fe na dose de 150 mg dm-3 de solo em comparação com 350 mg dm-3 de solo. O tratamento com Cu na dose de 350 mg dm-3 de solo reduziu o comprimento das raízes. Os tratamentos com Cu reduziram a massa seca das raízes. Os tratamentos com Fe afetaram o conteúdo de aminoácidos solúveis nos caules, folhas e cotilédones, bem como as proteínas solúveis totais nos cotilédones e o conteúdo de carboidrato nas folhas. Os tratamentos com Cu aumentaram os teores de proteínas e carboidratos nas folhas e o teor de amido nos cotilédones. Altas concentrações de Cu e Fe modificam a produção de compostos nitrogenados na planta e diminuem a biomassa radicular. (Fe (Cu metabólicas Porém raízes caules ensiformis vegetação casualizado foram controle, controle (controle 50 25 35 dm3 dm 3 1 dias avaliados entretanto EVI (EVI 15 dm- radicular 5 2

ABSTRACT Plants require iron (Fe) and copper (Cu) at low concentrations for metabolic functions; however, excess soil Fe and Cu can cause toxicity and affect plant development. The objective of this study was to assess the effects of soil Cu and Fe concentrations on seedling emergence, as well as on the metabolism of the main reserve compounds and the biomass in roots, stems, leaves, and cotyledons of Canavalia ensiformis. A greenhouse experiment was conducted in a completely randomized design; the Cu and Fe treatments in the soil were: (control, 50, 150, 250 and 350 mg dm-3) over a period of 10 days. Seedling emergence was not affected by the evaluated treatments; however, the results showed an increase in the emergence speed index (EVI) for the Fe treatment at a dose of 150 mg dm-3 of soil compared to 350 mg dm-3 of soil. Treatment with Cu at a dose of 350 mg dm-3 of soil reduced root length. Cu treatments reduced root dry mass. Fe treatments affected the content of soluble amino acids in the stems, leaves and cotyledons, as well as the total soluble proteins in the cotyledons and the carbohydrate content in the leaves. Cu treatments increased protein and carbohydrate content in leaves and starch content in cotyledons. High concentrations of Cu and Fe modify the production of nitrogenous compounds in the plant and reduce root biomass. (Fe (Cu functions however development roots stems ensiformis design were control, control (control 50 25 35 dm3 dm 3 1 days EVI (EVI 15 dm- length mass 5 2

https://doi.org/10.1590/1983-21252025v3812686rc

Non-destructive method for extracting DNA from cashew seeds Nondestructive Non destructive
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Castro, Érika Beatriz de Lima

; Souza Filho, Men de Sá Moreira de

; Bordallo, Patricia do Nascimento

Revista Ciência Agronômica

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2025, Volume 56 elocation e202392001

Abstract: En | Text: En | PDF: En

ABSTRACT The characterisation and evaluation of accessions are important steps in both the management of a germplasm collection and in a plant genetic improvement program. Carrying out characterisation and evaluation, whether morphological or molecular, requires observing the overall features of plants in the field, or collecting leaves for DNA extraction, which is time consuming and costly; whereas DNA extracted directly from the seeds allows access to the genome without the need for planting the seeds, which speeds up the selection of genotypes of interest and information on genetic variability. The aim was to develop a non-destructive method for extracting DNA from cashew seeds. The seeds were mechanically perforated using a mini-grinder, and a sample of the endosperm was removed. Various protocols and commercial kits for DNA extraction were tested, as well as materials to seal the opening made in the seed. It is possible to extract cashew tree DNA from the endosperm, preferably using commercial kits with cementitious adhesive as the sealing material, offering a germination percentage of 60% of the perforated seeds. program molecular field costly variability nondestructive non destructive minigrinder, minigrinder mini grinder, grinder mini-grinder removed tested seed material 60 6

https://doi.org/10.5935/1806-6690.20250008

Food insecurity and water insecurity measurement in Brazil: Sustainable Development Goals monitoring through experiential scales
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Salles-Costa, Rosana

; Cherol, Camilla Christine de Souza

; Palmeira, Poliana de Araújo

; Segall-Corrêa, Ana Maria

; Young, Sera Lewise

; Pérez-Escamilla, Rafael

; Lignani, Juliana de Bem

; Vianna, Rodrigo Pinheiro de Toledo

; Mata, Mayline Menezes da

; Medeiros, Maria Angélica Tavares de

; Pasquim, Elaine Martins

; Barbosa, Juliana Chaves

; Lima, Thainá Ferreira de

; García-Obregón, Olga Patrícia

; Gaitán-Rossi, Pablo

; Lima, Juliana Schober Gonçalves

; Grossi, Mauro Eduardo Del

; Voci, Silvia Maria

; Santos, Sandra Maria Chaves dos

; Melgar-Quiñonez, Hugo Ramiro

Cadernos de Saúde Pública

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2025, Volume 41 N. 2 elocation e00153524

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/0102-311xen153524

10.

Direct Methylation Method for Quantification of Fatty Acids in Lyophilized Human Milk by Gas Chromatography with Flame Ionization Detector
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Souza, Patrícia M.

; Santos, Patrícia D. S. Ponhozi, Isadora B. Cruz, Victor Hugo M. Pizzo, Jessica S. Alves, Eloize S. Santos, Oscar O. Visentainer, Jesuí V.

Journal of the Brazilian Chemical Society

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2025, Volume 36 N. 1 elocation e-20240077

Abstract: En | Text: En | PDF: En

This study aims to propose a new method for derivatizing fatty acids (FAs) from human milk (HM), eliminating the lipid extraction step, and simplifying the preparation for gas chromatography with a flame ionization detection (GC-FID) analysis to quantify the FAs. The Design Expert software optimized the reaction times, concentrations, and sample amount. The proposed method (PM) was validated for lyophilized HM and results for the figures of merit for precision in relative standard deviation (RSD) (RSDintra-day 1.34-4.03% and RSDinter day 2.08 5.16%), accuracy (99.87-102.16%), and robustness are within a linear range of 3 to 38% lipids in HM samples. The atmospheric solids analysis probe tandem mass spectrometry (ASAP-MS/MS) technique confirmed the efficiency of PM by expressing the molecular composition of triacylglycerol formed by FAs from the GC-FID technique. The PM requires a small sample size and conducts derivatization directly in the sample matrix, minimizing extraction errors. (FAs HM, , (HM) step GCFID GC FID (GC-FID times concentrations amount (PM RSD (RSD RSDintraday RSDintra 1.344.03% 134403 1.34 4.03% 1 34 4 03 1.34-4.03 208 2 08 2.0 5.16%, 516 5.16% 5 16 5.16%) 99.87102.16%, 998710216 99.87 102.16% 99 87 102 (99.87-102.16%) 38 samples ASAPMS/MS ASAPMSMS ASAP MS/MS MS (ASAP-MS/MS matrix errors (HM 344 1.344.03 13440 134 1.3 403 4.03 0 1.34-4.0 20 2. 51 5.16 87102 99.87102.16% 99871021 9987 99.8 10216 102.16 9 8 10 (99.87-102.16% ASAPMS MSMS 1.344.0 1344 13 1. 40 4.0 1.34-4. 5.1 8710 99.87102.16 9987102 998 99. 1021 102.1 (99.87-102.16 1.344. 4. 1.34-4 5. 871 99.87102.1 998710 102. (99.87-102.1 1.344 1.34- 99.87102. 99871 (99.87-102. 99.87102 (99.87-102 99.8710 (99.87-10 99.871 (99.87-1 (99.87- (99.87 (99.8 (99. (99 (9 (

https://doi.org/10.21577/0103-5053.20240077

11.

MAJOR INORGANIC IONS IN BULK PRECIPITATION FROM COASTAL URBAN AND MONTANE ATLANTIC FOREST SITES IN SOUTHEASTERN BRAZIL
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Souza, Patricia A. de

; Mello, William Z. de

Química Nova

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2025, Volume 48 N. 3 elocation e-20250044

Abstract: En | Text: En | PDF: En

Bulk precipitation (BP) samples were collected at two coastal urban sites and two montane Atlantic Forest (400 and 1000 m altitude) areas in southeastern Brazil from August 2008 to August 2009. These samples were analyzed for the major inorganic ions (H+, Na+, K+, Ca2+, Mg2+, Cl- and SO42-) found in rainwater. The concentrations of inorganic nitrogen species (NH4+, NO3- and NO2-) were compiled from a previous study. The volume-weighted mean (VWM) concentrations of inorganic ions differed spatially, with higher values at the coastal urban and coastal periurban sites. On a molar basis, Cl- and Na+ together comprised 60% of the total inorganic constituents at the coastal urban site and 34-42% at the other three sites, as it is the closest to the ocean. Magnesium was also primarily associated with sea-salt aerosol. Non-sea-salt (nss) fractions of K+, Ca2+ and SO42- comprised 68-93% of their VWM concentrations, indicating the contribution of natural (mostly biogenic) and anthropogenic (SO2 oxidation for the latter) sources. Finally, we found that the acidity of BP at the four sampling sites is primarily controlled by the NH4+, nss-Ca2+, nss-SO42-, and NO3- ions, resulting in VWM pH values ranging from 5.60 (lower montane forest) to 5.98 (coastal periurban site). (BP 400 (40 100 altitude 200 2009 H+, H (H+ Na K K+ Ca2 Ca Mg2 Mg Mg2+ Cl SO42 SO rainwater NH4 NH (NH4+ NO3 NO NO2 NO2- study volumeweighted volume weighted (VWM spatially basis 60 3442% 3442 34 42% 42 34-42 ocean seasalt sea salt aerosol Nonseasalt Non nss (nss 6893% 6893 68 93% 93 68-93 mostly biogenic SO2 (SO latter sources Finally NH4+ nssCa2+, nssCa2 nssCa nss-Ca2+ nssSO42, nssSO42 nssSO , nss-SO42- 560 5 5.6 lower forest 598 98 5.9 site. . site) 40 (4 10 20 H+ (H SO4 (NH4 6 344 3 4 34-4 689 9 68-9 nssCa2+ nss-Ca2 nssSO4 nss-SO42 56 5. 59 ( 1 2 (NH 34- 68- nss-Ca nss-SO4 nss-SO

https://doi.org/10.21577/0100-4042.20250044

12.

UMA PROPOSTA DIDÁTICO-PEDAGÓGICA UTILIZANDO UM SOFTWARE LIVRE PARA INTERPRETAR A PCA DIDÁTICOPEDAGÓGICA DIDÁTICO PEDAGÓGICA
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Silva, Rebeca Fernanda de Souza e

; Deimling, Natália Neves Macedo Valderrama, Patrícia

Química Nova

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2025, Volume 48 N. 2 elocation e-20250027

Abstract: Pt | Text: Pt | PDF: Pt

Chemometrics is gaining more and more space in universities and industry. To contribute to the development and expansion of principal component analysis (PCA) teaching proposals, this work evaluated the answers of the students to a questionnaire and presented a didactic-pedagogical proposal that can contribute to solving the principal doubts achieved by students in the PCA interpretation. Based on data collected in a semi-open questionnaire, the proposal was developed based on methodological principles of historical-critical pedagogy, containing the objectives, the problems surrounding the topic, and the cultural instruments necessary for understanding and interpreting PCA in the discipline of chemometrics by using new resources and instruments, especially free software, Chemostat. This proposal covers topics related to the concept of chemometrics and PCA, the explanation of the data set, pre-processing, use of Chemostat software, and analysis of principal components. It is hoped that this proposal can promote a better understanding concerning PCA on the part of students, as well as effective incorporation of the phenomena that involve this tool and its applications, and interpretation. Likewise, it is expected that this didactic-pedagogical proposal can support new teaching practices in chemometrics subjects in higher education. industry (PCA proposals didacticpedagogical didactic pedagogical interpretation semiopen semi open historicalcritical historical critical pedagogy objectives topic software set preprocessing, preprocessing pre processing, processing pre-processing components applications Likewise education

https://doi.org/10.21577/0100-4042.20250027

13.

Ecoeficiência de concretos autoadensáveis com resíduo de louça sanitária
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Souza, Régis Marciano de

; Ortigara, Yuri Vilas Boas

; Gomes, Carlos Eduardo Marmorato

; Magalhães, Ricardo Rodrigues

; Fontanini, Patrícia Stella Pucharelli

; Campos, Alessandro Torres

Ambiente Construído

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dec 2024, Volume 24 elocation e128733

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O resíduo de louça sanitária (RLS) é alvitrado como uma alternativa ecologicamente ambiental, em substituição aos agregados finos e pedriscos, empregados na produção de concretos autoadensáveis (CAA). A eficiência ambiental nos ciclos de vida energético e das emissões de dióxido de carbono de CAA com diferentes misturas de RLS, foram comparadas com o concreto autoadensável sem RLS (CAA_REF). A Análise do Ciclo de Vida (ACV) evidenciou que a substituição de agregados de RLS em CAA_REF, pode gerar uma redução absoluta de aproximadamente 34,70 MJ/m³ e 2,07 kg de CO2/m³, respectivamente, o que corresponde a reduções de 1,5% e 0,5%. Verificou-se ainda que o uso de um indicador de ecoeficiência do comportamento ambiental em relação ao parâmetro resistência mecânica à compressão, pode contribuir e ser adequado em projetos de dosagens de CAA. Assim, observou-se que o uso de RLS, pode colaborar para a sustentabilidade ambiental, reduzindo a disposição inadequada dos RLS no meio ambiente e implementado um reuso adequado. (RLS pedriscos . (CAA) CAA_REF. CAAREF CAA_REF REF (CAA_REF) ACV (ACV 3470 34 70 34,7 MJm³ MJm MJ m³ m MJ/m 207 2 07 2,0 CO2m³ COm CO2 CO CO2/m³ respectivamente 15 1 5 1,5 05 0 0,5% Verificouse Verificou se compressão Assim observouse observou (CAA (CAA_REF 347 3 7 34, 20 2, CO2m CO2/m 1, 0,5 0,

Abstract Sanitary ware waste (RLS) is proposed as an ecologically environmental alternative, replacing fine aggregates and gravel, used in the production of self-compacting concrete (SCC). The environmental efficiency in energy life cycles and carbon dioxide emissions of SCC with different mixtures of RLS, were compared with the self-compacting concrete without RLS (CAA_REF). The Life Cycle Assessment (LCA) showed that the replacement of RLS aggregates in CAA_REF, can generate an absolute reduction of approximately 45.42 MJ/m³ and 2.67 kg of CO2/m³ respectively, which corresponds to reductions of 2.2% and 0.6%. It was also verified that the use of an indicator of eco-efficiency of the environmental behavior in relation to the parameter mechanical resistance to compression, can contribute and be adequate in projects of dosages of SCC. Thus, it was observed that the use of RLS can contribute to environmental sustainability, reducing the inadequate disposal of RLS in the environment and implementing an adequate reuse. (RLS alternative gravel selfcompacting self compacting . (SCC) CAA_REF. CAAREF CAA_REF CAA REF (CAA_REF) LCA (LCA 4542 45 42 45.4 MJm³ MJm MJ m³ m MJ/m 267 2 67 2.6 CO2m³ COm CO2 CO CO2/m respectively 22 2.2 06 0 6 0.6% ecoefficiency eco compression Thus sustainability reuse (SCC (CAA_REF 454 4 45. 26 2. CO2m 0.6 0.

https://doi.org/10.1590/s1678-86212024000100739

14.

A REALIDADE AUMENTADA NO ENSINO E APRENDIZAGEM DE VOCABULÁRIO EM LÍNGUA INGLESA
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Ferreira, Maria Cristina

; Ribeiro, Patrícia Nora de Souza

Trabalhos em Linguística Aplicada

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dec 2024, Volume 63 N. 3 Pages 632 - 643

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Considerando a carência de trabalhos sobre as potencialidades dos ambientes imersivos na educação, este artigo busca investigar a relevância da Realidade Aumentada no ensino e aprendizagem de vocabulário em inglês como língua estrangeira a curto e longo prazo. Investiga-se também os efeitos deste ambiente imersivo em alunos com diferentes níveis de proficiência, a saber: níveis elementar e intermediário. No âmbito teórico, o estudo é fundamentado nos pressupostos da Teoria da Cognição Corporifica que concebe a mente e nossas experiências corporais com o mundo externo elementos centrais no processamento e aquisição de conhecimento. No âmbito metodológico, o ambiente em Realidade Aumentada usado na presente pesquisa foi aplicado a 15 alunos do Ensino Técnico Integrado ao Ensino Médio do IFRJ, campus Eng. Paulo de Frontin e os dados obtidos foram gerados por meio de testes de vocabulário e questionário. Os resultados indicam que o ambiente em Realidade Aumentada pode contribuir significativamente para o aprendizado de vocabulário tanto a curto quanto a longo prazo, com destaque para os alunos de nível intermediário que foram os que mais se beneficiaram do ambiente testado. educação prazo Investigase Investiga proficiência saber teórico conhecimento metodológico 1 IFRJ Eng questionário testado

ABSTRACT Considering the need for studies on the potential of immersive environments in education, this paper aims to investigate the relevance of Augmented Reality in ESL/EFL in the shortand long-term vocabulary learning. It also investigates the effects of this immersive environment on students with different proficiency levels, elementary and intermediate levels. Theoretically, the study is based on the assumptions of the Embodied Cognition theory, which considers the mind and our bodily experiences with the external world as central elements in the processing and acquisition of knowledge. In the methodological scope, the Augmented Reality environment used in this research was applied to 15 students of Ensino Técnico Integrado ao Ensino Médio do IFRJ, campus Eng. Paulo de Frontin and the data collected were generated through vocabulary tests and a questionnaire. The results indicate that the Augmented Reality environment can significantly contribute to vocabulary learning in the short and long term, especially for intermediate level students who benefited the most from the tested environment. education ESLEFL ESL EFL longterm term levels Theoretically theory knowledge scope 1 IFRJ Eng questionnaire

https://doi.org/10.1590/01031813v63320248671423

15.

An extraskeletal Ewing’s sarcoma: a challenging diagnosis with several approaches in a young woman
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Oliveira, Carolina Souza-de Mendes-Alexandre, Isabella C. Hollanda, Laísa Ezaguy-de Oliveira-Alves-Melo-Martins, Rebeca de Ribeiro-Ferreira, Vanessa Chagas-Rossin, João V. Babani, Hitesh Melo, Patricia Chicre-Bandeira-de Santos, Luciana Mendes-dos

Portuguese Journal of Dermatology and Venereology

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sep 2024, Volume 82 N. 3 Pages 183 - 186

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O sarcoma de Ewing extraesquelético (SEE) é um tumor primário incomum dos tecidos moles profundos. Clinicamente, as lesões cutâneas costumam ter crescimento rápido, agressivo, com risco de metástase, sendo mais comum na região paravertebral e nos membros inferiores. O diagnóstico definitivo é feito através do estudo anatomopatológico. Apresenta-se neste relato o caso de uma paciente de 21 anos, com tumoração em flanco direito há 2 meses, submetida a abordagens cirúrgicas em serviço de pronto atendimento, evoluindo com piora progressiva do quadro.

Abstract Extraskeletal Ewing’s sarcoma is an unusual primary tumor of the deep soft tissues. Clinically, skin lesions are usually fast-growing and aggressive, with a risk of metastasis, and are more common in the paravertebral region and lower limbs. The ultimate diagnosis is made by anatomopathological study. This report describes the case of a 21-year-old patient with a tumor on her right flank that had been present for the past 2 months. She underwent surgery in an emergency department and progressively became more ill.

https://doi.org/10.24875/pjdv.24000020

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