RESUMO: A leptospirose é uma doença zoonótica que deve ser estudada sob o ponto de vista da Saúde Única. É possível que existam particularidades na epidemiologia da leptospirose no bioma Caatinga, onde o ambiente é muitas vezes desfavorável e desafia a adaptabilidade de Leptospira spp. No total, 100 cães (47 de abrigos e 53 errantes) selecionados com base em cálculo amostral foram utilizados para avaliar a soroprevalência de Leptospira spp. e os fatores associados. O teste de soroaglutinação microscópica (SAM) foi aplicado para detetar anticorpos anti-Leptospira spp. (título 50 como ponto de corte). Os fatores de risco foram identificados utilizando a análise de regressão de Poisson robusta. Vinte e quatro animais (24%; IC 95% = 15,6% - 32,4%) foram soropositivos, os títulos de anticorpos variaram de 50 a 200, e os serogrupos reagentes foram Ballum (17%), Autumnalis (6%) e Djasiman (1%). Os fatores/categorias associados à seropositividade foram o ambiente onde o animal se encontra/solo (razão de prevalência [RP] = 6,03; IC 95% para RP: 1,86 - 7,69; P < 0,001) e o acesso a água poluída/sim (RP = 3,79; IC 95% para RP: 1,85 - 24,22; P = 0,011). Os resultados sugerem a leptospirose como uma preocupação no contexto da Saúde Única em cães errantes e de abrigos no bioma Caatinga, apesar das condições adversas desse bioma para a sobrevivência de Leptospira spp. no ambiente. Além disso, apesar de serem questões sociais e governamentais, fatores como o ambiente onde o animal fica (solo) e o acesso à água poluída devem ser cuidadosamente analisados e corrigidos para evitar a transmissão de leptospiras para animais e humanos. RESUMO Caatinga spp total 10 47 (4 5 SAM (SAM antiLeptospira anti título corte. corte . corte) robusta 24% 24 (24% 95 156 15 6 15,6 32,4% 324 32 4 soropositivos 200 17%, 17 17% , (17%) 6% (6% 1%. 1 1% (1%) fatorescategorias categorias encontrasolo encontra solo razão RP [RP 6,03 603 03 186 86 1,8 7,69 769 7 69 0,001 0001 0 001 poluídasim sim 3,79 379 3 79 185 85 24,22 2422 22 0,011. 0011 0,011 011 0,011) disso governamentais (solo humanos ( 2 (24 9 15, 32,4 20 (17% (6 (1% 6,0 60 18 8 1, 7,6 76 0,00 000 00 3,7 37 24,2 242 0,01 01 (2 32, (17 (1 6, 7, 0,0 3, 24, 0,

ABSTRACT: Leptospirosis is a zoonotic disease that must be studied on the One Health point of view. It is possible that there are particularities in the epidemiology of leptospirosis in Caatinga biome, where the environment is often unfavorable and challenges the adaptability of Leptospira spp. Overall, 100 dogs (47 shelter and 53 stray dogs) selected based on sampling calculation were used to evaluate the Leptospira spp. seroprevalence and associated factors. The microscopic agglutination test (MAT) was applied to detect anti-Leptospira spp. antibodies (cut-off titer 50). Risk factors were identified using the robust Poisson regression analysis. Twenty-four animals (24%; 95% CI = 15.6% - 32.4%) were seroreactive, antibody titers ranged from 50 to 200, and the reacting serogroups were Ballum (17%), Autumnalis (6%) and Djasiman (1%). The factors/categories associated with seropositivity were the environment where the animal stay/soil (prevalence ratio [PR] = 6.03; 95% CI for PR: 1.86 - 7.69; P < 0.001) and access to polluted water/yes (PR = 3.79; 95% CI for PR: 1.85 - 24.22; P = 0.011). The results suggested leptospirosis as a concern in the One Health context in stray and shelter dogs from the Caatinga biome despite the adverse conditions of this biome for the survive of Leptospira spp. on the environment. Moreover, despite being social and government issues, factors such as environment where the animal stay (soil) and access to polluted water must be carefully deemed and corrected to avoid the transmission of leptospires to animals and humans. ABSTRACT view spp Overall 10 47 (4 5 MAT (MAT antiLeptospira anti cutoff cut off 50. . 50) analysis Twentyfour Twenty four 24% 24 (24% 95 156 15 6 15.6 32.4% 324 32 4 seroreactive 200 17%, 17 17% , (17%) 6% (6% 1%. 1 1% (1%) factorscategories categories staysoil soil prevalence PR [PR 6.03 603 03 186 86 1.8 7.69 769 7 69 0.001 0001 0 001 wateryes yes 3.79 379 3 79 185 85 24.22 2422 22 0.011. 0011 0.011 011 0.011) Moreover issues (soil humans ( 2 (24 9 15. 32.4 20 (17% (6 (1% 6.0 60 18 8 1. 7.6 76 0.00 000 00 3.7 37 24.2 242 0.01 01 (2 32. (17 (1 6. 7. 0.0 3. 24. 0.

Resumo Objetivou-se analisar os fatores associados ao policonsumo de álcool, tabaco e drogas ilícitas, entre adolescentes escolares brasileiros de 13 a 17 anos. Estudo transversal, com dados da Pesquisa Nacional de Saúde do Escolar (2019). A variável desfecho foi o relato de consumo das três substâncias nos últimos 30 dias. As variáveis independentes foram agrupadas em quatro blocos: características sociodemográficas; contexto familiar; situações estressoras; aspectos comportamentais. Foi realizada análise de regressão logística múltipla hierarquizada, permanecendo no modelo final as variáveis com p<0,05. A prevalência de policonsumo em adolescentes escolares foi 3,3%. No modelo final, sexo masculino, morar na região Centro-Oeste, Sul e Sudeste, faltar a escola sem permissão, pais não saberem o que fazem no tempo livre, ter pais fumantes, sofrer agressão física pelos pais, sentir que a vida não vale a pena ser vivida, experimentar bebida alcoólica e drogas ilícitas antes dos 13 anos, ter amigos que bebem bebida alcoólica, fumam e usam drogas na sua presença permaneceram associados ao desfecho. Os dados mostram alta prevalência de policonsumo de três substâncias entre adolescentes e sua associação a fatores sociodemográficos, familiares, comportamentais e a eventos estressantes.

Abstract The aim of this study was to analyze the factors associated with concurrent alcohol, tobacco and illicit drug use among Brazilian schoolchildren aged 13-17. We conducted a cross-sectional study using data from the 2019 National School-Based Health Survey. The outcome was use of the three substances during the last 30 days. Hierarchical multiple logistic regression was carried out with independent variables grouped into four blocks: sociodemographic characteristics; family context; behavioral aspects; and stressors. Variables with p<0.05 were retained in the final model. The prevalence of concurrent substance use was 3.3%. Being male, living in the Midwest, South and Southeast, skipping school without parent permission, parents not knowing what their children do in their free time, having parents who smoke, having experienced physical aggression from parents, feeling that life is not worth living, trying drinking and illicit drugs before the age of 13, and having friends who drink alcohol, smoke and use drugs in their presence remained associated with the outcome in the final model. The findings reveal high prevalence of concurrent alcohol, cigarette and illicit drug use among adolescents and that poly use is associated with sociodemographic, family, and behavioral factors and stressors.

Abstract Introduction: Methylene Blue (MB) has been shown to attenuate oxidative, inflammatory, myocardial, and neurological lesions during ischemia-reperfusion and has great potential during cardiac arrest. This study aimed to determine the effects of MB combined with epinephrine during cardiac arrest on myocardial and cerebral lesions. Method: Thirty-eight male Wistar rats were randomly assigned to four groups: the sham group (SH, n = 5), and three groups subjected to cardiac arrest (n = 11 /group) and treated with EPI 20 μg.kg−1 (EPI), EPI 20 μg.kg−1 + MB 2 mg.kg−1 (EPI + MB), or saline 0.9% 0.2 ml (CTL). Ventricular fibrillation was induced by direct electrical stimulation in the right ventricle for 3 minutes, and anoxia was maintained for 5 minutes. Cardiopulmonary Resuscitation (CPR) consisted of medications, ventilation, chest compressions, and defibrillation. After returning to spontaneous circulation, animals were observed for four hours. Blood gas, troponin, oxidative stress, histology, and TUNEL staining measurements were analyzed. Groups were compared using generalized estimating equations. Results: No differences in the Returning of Spontaneous Circulation (ROSC) rate were observed among the groups (EPI: 63%, EPI + MB: 45%, CTL: 40%, p = 0.672). The mean arterial pressure immediately after ROSC was higher in the EPI+MB group than in the CTRL group (CTL: 30.5 [5.8], EPI: 63 [25.5], EPI+MB: 123 [31] mmHg, p = 0.007). Serum troponin levels were high in the CTL group (CTL: 130.1 [333.8], EPI: 3.70 [36.0], EPI +MB: 43.7 [116.31] ng/mL, p < 0.05). Conclusion: The coadministration of MB and epinephrine failed to yield enhancements in cardiac or brain lesions in a rodent model of cardiac arrest. Introduction (MB inflammatory ischemiareperfusion ischemia reperfusion Method Thirtyeight Thirty eight SH, SH (SH 5, , 5) 1 /group μgkg1 μgkg μg kg μg.kg− EPI, (EPI) mgkg1 mgkg mg mg.kg− MB, MB) 09 0 9 0.9 02 0. CTL. . (CTL) minutes CPR (CPR medications ventilation compressions defibrillation circulation hours gas stress histology analyzed equations Results (ROSC 63% 45 45% 40 40% 0.672. 0672 0.672 672 0.672) EPIMB (CTL 305 30 30. 5.8, 58 5.8 8 [5.8] 6 25.5, 255 25.5 25 [25.5] 12 31 [31 mmHg 0.007. 0007 0.007 007 0.007) 1301 130 130. 333.8, 3338 333.8 333 [333.8] 370 70 3.7 36.0, 360 36.0 36 [36.0] +MB 437 43 7 43. 116.31 11631 116 [116.31 ngmL ng mL ng/mL 0.05. 005 0.05 05 0.05) Conclusion μg.kg mg.kg 4 067 0.67 67 5. [5.8 25. [25.5 [3 000 0.00 00 13 333. 33 [333.8 37 3. 36. [36.0 116.3 1163 [116.3 0.0 06 0.6 [5. [25. [ [333. [36. 116. [116. [5 [25 [333 [36 [116 [2 [33 [11 [1

RESUMO A desnutrição/sarcopenia é frequente em pacientes com doenças inflamatórias intestinais (DII), resultando em catabolismo muscular, com impacto nas respostas aos tratamentos, complicações cirúrgicas e na qualidade de vida. Objetivo: Este estudo tem como objetivo, avaliar se o ângulo de fase (AF) é um parâmetro para a predição de redução de massa muscular em pacientes com DII. Métodos: Pacientes adultos com DII foram incluídos neste estudo transversal. A estimativa da massa muscular e o cálculo do AF foram realizados a partir do exame de bioimpedância elétrica (BIA). As atividades da doença de Crohn e retocolite ulcerativa foram definidas pelo índice Harvey-Bradshaw e escore parcial de Mayo, respectivamente. A área de curva ROC foi calculada para identificar o ponto de corte do AF para a massa muscular reduzida. Resultados: A amostra foi composta por 145 pacientes, sendo 39 (26.9%) com DII em fase ativa. Houve correlação do AF com massa muscular esquelética (MME) (rs 0.35, P<0.001) e com o índice de massa muscular esquelética (IMME) (rs 0.427, P<0.001), mantendo-se as associações na forma mais ativa (moderada ou grave) da DII. A análise da curva ROC indicou que os pontos de corte de AF ≤5.042 para mulheres e ≤6.079 para homens podem ser usados para prever a redução da massa muscular. Conclusão: O AF pode ser considerado um preditor de redução de massa muscular nos pacientes com DII e ser utilizado para triagem e acompanhamento da evolução da desnutrição. desnutriçãosarcopenia desnutrição sarcopenia DII, , (DII) tratamentos vida Objetivo objetivo (AF Métodos transversal BIA. BIA . (BIA) HarveyBradshaw Harvey Bradshaw Mayo respectivamente reduzida Resultados 14 3 26.9% 269 26 9 (26.9% MME (MME rs 035 0 35 0.35 P<0.001 P0001 P 001 IMME (IMME 0427 427 0.427 P<0.001, mantendose mantendo moderada grave 5042 5 042 ≤5.04 6079 6 079 ≤6.07 Conclusão (DII (BIA 1 26.9 2 (26.9 03 0.3 P<0.00 P000 00 42 0.42 504 04 ≤5.0 607 07 ≤6.0 26. (26. 0. P<0.0 P00 4 0.4 50 ≤5. 60 ≤6. (26 P<0. P0 ≤5 ≤6 (2 P<0 ≤ ( P<

ABSTRACT Malnutrition/sarcopenia is frequent in patients with inflammatory bowel diseases (IBD), and results in muscle catabolism, impacting treatment response, postoperative complications, and quality of life. Objective: This study aims to assess whether the phase angle (PhA) is a parameter for predicting reduced muscle mass in patients with IBD. Methods: Adult patients with IBD were included in this cross-sectional study. For the estimation of muscle mass and the calculation of the PhA, we used bioelectrical impedance analysis (BIA). Crohn’s disease (CD) and ulcerative colitis (UC) activity scores were defined using the Harvey-Bradshaw index and partial Mayo score, respectively. The area under the ROC curve was calculated to identify the PhA cut-off point for reduced muscle mass. Results: The sample consisted of 145 patients, with 39 (26.9%) with IBD in the active phase. There was a correlation of the PhA with skeletal muscle mass (SMM) (rs 0.35, P<0.001) and with the skeletal muscle mass index (SMI) (rs 0.427, P<0.001), and the associations remained in the most active form (moderate or severe) of IBD. The ROC curve analysis indicated that the cut-offs points of the PhA ≤5.042 for female and PhA ≤6.079 for male can be used to predict muscle mass reduction. Conclusion: The PhA can be considered a predictor of muscle mass reduction in IBD patients, and we can use it for screening and monitoring the evolution of malnutrition. Malnutritionsarcopenia Malnutrition sarcopenia IBD, , (IBD) catabolism response complications life Objective (PhA Methods crosssectional cross sectional BIA. BIA . (BIA) Crohns Crohn s CD (CD UC (UC HarveyBradshaw Harvey Bradshaw score respectively cutoff cut off Results 14 3 26.9% 269 26 9 (26.9% SMM (SMM rs 035 0 35 0.35 P<0.001 P0001 P 001 SMI (SMI 0427 427 0.427 P<0.001, moderate severe cutoffs offs 5042 5 042 ≤5.04 6079 6 079 ≤6.07 Conclusion malnutrition (IBD (BIA 1 26.9 2 (26.9 03 0.3 P<0.00 P000 00 42 0.42 504 04 ≤5.0 607 07 ≤6.0 26. (26. 0. P<0.0 P00 4 0.4 50 ≤5. 60 ≤6. (26 P<0. P0 ≤5 ≤6 (2 P<0 ≤ ( P<

Objetivo: avaliar a eficácia de um programa no aumento das estratégias de coping focadas no problema e na emoção em bombeiros militares. Método: ensaio clínico randomizado, paralelo, com mascaramento simples. A amostra constituiu-se de 51 participantes no grupo intervenção e 49 no controle. O grupo intervenção recebeu o programa interventivo incluindo as estratégias de coping pautadas na Classificação das Intervenções de Enfermagem, com duração de seis semanas consecutivas, um dia por semana. O grupo controle seguiu a rotina da Unidade de Serviço. Para as análises utilizou-se estatística descritiva, teste T de Student com correção de Welch e o teste de Mann-Whitney. A magnitude do efeito da intervenção foi calculada com o índice d de Cohen. Considerou-se valor p ≤0,05%. Resultados: na análise da média da diferença entre os escores nos grupos, as médias do grupo intervenção aumentaram significativamente para as estratégias de coping : suporte social ( p = 0,009), aceitação da responsabilidade ( p = 0,03), resolução de problemas ( p = 0,05) e reavaliação positiva ( p = 0,05). O impacto da intervenção apresentou magnitude moderada para o suporte social (d = 0,54). Conclusão: o programa interventivo possibilitou o aumento de estratégias de coping focadas no problema e na emoção em bombeiros militares. ReBEC: RBR-8dmbzc. Objetivo militares Método randomizado paralelo simples constituiuse constituiu se 5 4 Enfermagem consecutivas semana Serviço utilizouse utilizou descritiva MannWhitney. MannWhitney Mann Whitney. Whitney Mann-Whitney Cohen Considerouse Considerou 005 0 05 ≤0,05% Resultados grupos 0,009, 0009 0,009 , 009 0,009) 0,03, 003 0,03 03 0,03) 0,05 0,05. . 0,54. 054 0,54 54 0,54) Conclusão ReBEC RBR8dmbzc. RBR8dmbzc RBRdmbzc RBR 8dmbzc. 8dmbzc dmbzc RBR-8dmbzc 00 ≤0,05 000 0,00 0,0 0,5 ≤0,0 0, ≤0, ≤0 ≤

Objective: to evaluate the effectiveness of a program in increasing coping strategies focused on military firefighters’ problems and emotions. Method: randomized, parallel, single-masked clinical trial. The sample consisted of 51 participants in the intervention group and 49 in the control group. The intervention group received the intervention program including coping strategies based on the Nursing Interventions Classification, lasting six consecutive weeks, one day a week. The control group followed the Service Unit routine. Descriptive statistics, Student’s T test with Welch’s correction and the Mann-Whitney test were used for the analyses. The magnitude of the intervention effect was calculated using Cohen’s d index. A p-value of ≤0.05% was considered. Results: in the analysis of the mean difference between the scores in the groups, the means of the intervention group increased significantly for the coping strategies: social support (p = 0.009), acceptance of responsibility (p = 0.03), problem solving (p = 0.05) and positive reappraisal (p = 0.05). The impact of the intervention was moderate in magnitude for social support (d = 0.54). Conclusion: the intervention program enabled the increase of coping strategies focused on military firefighters’ problems and emotions. ReBEC: RBR-8dmbzc. Objective firefighters emotions Method randomized parallel singlemasked single masked trial 5 4 Classification weeks week routine statistics Students Student s Welchs Welch MannWhitney Mann Whitney analyses Cohens Cohen index pvalue p value 005 0 05 ≤0.05 considered Results groups 0.009, 0009 0.009 , 009 0.009) 0.03, 003 0.03 03 0.03) 0.05 0.05. . 0.54. 054 0.54 54 0.54) Conclusion ReBEC RBR8dmbzc. RBR8dmbzc RBRdmbzc RBR 8dmbzc. 8dmbzc dmbzc RBR-8dmbzc 00 ≤0.0 000 0.00 0.0 0.5 ≤0. 0. ≤0 ≤

Objetivo: evaluar la eficacia de un programa en el aumento de las estrategias de coping enfocadas en el problema y en la emoción en bomberos militares. Método: ensayo clínico aleatorizado, paralelo, con enmascaramiento simple. La muestra se constituyó de 51 participantes en el grupo intervención y 49 en el control. El grupo intervención recibió el programa interventivo incluyendo las estrategias de coping basadas en la Clasificación de las Intervenciones de Enfermería, con una duración de seis semanas consecutivas, un día por semana. El grupo control siguió la rutina de la Unidad de Servicio. Para los análisis se utilizó estadística descriptiva, test T de Student con corrección de Welch y el test de Mann-Whitney. La magnitud del efecto de la intervención se calculó con el índice d de Cohen. Se consideró valor p≤0,05%. Resultados: en el análisis del promedio de la diferencia entre los puntajes en los grupos, los promedios del grupo intervención aumentaron significativamente para las estrategias de coping : soporte social ( p = 0,009), aceptación de la responsabilidad ( p = 0,03), resolución de problemas ( p = 0,05) y reevaluación positiva ( p = 0,05). El impacto de la intervención presentó magnitud moderada para el soporte social ( d = 0,54). Conclusión: el programa interventivo posibilitó el aumento de estrategias de coping enfocadas en el problema y en la emoción en bomberos militares. ReBEC: RBR-8dmbzc. Objetivo militares Método aleatorizado paralelo simple 5 4 Enfermería consecutivas semana Servicio descriptiva MannWhitney. MannWhitney Mann Whitney. Whitney Mann-Whitney Cohen p005 0 05 p≤0,05% Resultados grupos 0,009, 0009 0,009 , 009 0,009) 0,03, 003 0,03 03 0,03) 0,05 005 0,05. . 0,54. 054 0,54 54 0,54) Conclusión ReBEC RBR8dmbzc. RBR8dmbzc RBRdmbzc RBR 8dmbzc. 8dmbzc dmbzc RBR-8dmbzc p00 p≤0,05 000 0,00 00 0,0 0,5 p0 p≤0,0 0, p≤0, p≤0 p≤

Abstract Background: The optimal amount for initial fluid resuscitation is still controversial in sepsis and the contribution of non-resuscitation fluids in fluid balance is unclear. We aimed to investigate the main components of fluid intake and fluid balance in both survivors and non-survivor patients with septic shock within the first 72 hours. Methods: In this prospective observational study in two intensive care units, we recorded all fluids administered intravenously, orally, or enterally, and losses during specific time intervals from vasopressor initiation: T1 (up to 24 hours), T2 (24 to 48 hours) and T3 (48 to 72 hours). Logistic regression and a mathematical model assessed the association with mortality and the influence of severity of illness. Results: We included 139 patients. The main components of fluid intake varied across different time intervals, with resuscitation and non-resuscitation fluids such as antimicrobials and maintenance fluids being significant contributors in T1 and nutritional therapy in T2/T3. A positive fluid balance both in T1 and T2 was associated with mortality (p = 0.049; p = 0.003), while nutritional support in T2 was associated with lower mortality (p = 0.040). The association with mortality was not explained by severity of illness scores. Conclusions: Non-resuscitation fluids are major contributors to a positive fluid balance within the first 48 hours of resuscitation. A positive fluid balance in the first 24 and 48 hours seems to independently increase the risk of death, while higher amount of nutrition seems protective. This data might inform fluid stewardship strategies aiming to improve outcomes and minimize complications in sepsis. Background nonresuscitation non unclear nonsurvivor survivor 7 Methods units intravenously orally enterally initiation T up 2 hours, , (2 4 (4 . Results 13 T2T3 TT T2/T3 0.049 0049 0 049 0.003, 0003 0.003 003 0.003) 0.040. 0040 0.040 040 0.040) scores Conclusions Nonresuscitation Non death protective ( 1 T2T T2/T 0.04 004 04 000 0.00 00 0.0 0.

ABSTRACT Objective: Abdominal ultrasonography is widely used to evaluate suspected cases of appendicitis. Objective descriptions of the direct and indirect signs of appendicitis result in varied assessments of its likelihood. This study introduces the Appendix Imaging Reporting and Data System (APENDIC-RADS) to standardize the reporting of appendix ultrasound findings. Methods: This single-center retrospective study included consecutive patients of all ages who underwent abdominal ultrasonography for the investigation of acute appendicitis. The primary outcome was histopathological confirmation of acute appendicitis post-surgery. The imaging findings were classified into five categories: APENDIC-RADS 0, where the appendix cannot be visualized; APENDIC-RADS 1, indicating a normal appendix; APENDIC-RADS 2, describing an appendix that is likely normal but only partially visualized; APENDIC-RADS 3, appendicitis cannot be ruled out due to uncertain features and APENDIC-RADS 4, acute appendicitis. Results: A total of 747 patients were assessed for suspected acute appendicitis using ultrasonography. Of the diagnosed patients, 52% were male, primarily exhibiting symptoms such as nausea and/or vomiting (60%), right iliac fossa pain (54%), and sudden decompression in the right iliac fossa (24%). Stratification into APENDIC-RADS categories revealed a significant variation in the incidence of acute appendicitis, with incidence rates of 4.5% for category 0 and 0.7%, 2.2%, 11.5%, and 93.5% for categories 1 to 4, respectively (p<0.001). The APENDIC-RADS showed excellent discriminative ability, evidenced by an area under the receiver operating characteristic curve of 0.950 (95%CI=0.899-1). Conclusion: APENDIC-RADS categorization demonstrated excellent performance in standardizing the ultrasound-determined probability of acute appendicitis. Its implementation could improve physician communication and standardization of patient management. likelihood APENDICRADS APENDIC RADS (APENDIC-RADS Methods singlecenter single center postsurgery. postsurgery post surgery. surgery post-surgery visualized 2 3 4 Results 74 52 male andor or 60%, 60 60% , (60%) 54%, 54 54% (54%) 24%. 24 24% . (24%) 45 5 4.5 07 7 0.7% 22 2.2% 115 11 11.5% 935 93 93.5 p<0.001. p0001 p p<0.001 001 (p<0.001) ability 0950 950 0.95 95%CI=0.8991. 95CI08991 CI 95%CI=0.899 95 899 (95%CI=0.899-1) Conclusion ultrasounddetermined determined management 6 (60% (54% (24% 4. 0.7 2.2 11.5 9 93. p000 p<0.00 00 (p<0.001 095 0.9 8991 95%CI=0.8991 95CI0899 95%CI=0.89 89 (95%CI=0.899-1 (60 (54 (24 0. 2. 11. p00 p<0.0 (p<0.00 09 95CI089 95%CI=0.8 8 (95%CI=0.899- (6 (5 (2 p0 p<0. (p<0.0 95CI08 95%CI=0. (95%CI=0.899 ( p<0 (p<0. 95CI0 95%CI=0 (95%CI=0.89 p< (p<0 95CI 95%CI= (95%CI=0.8 (p< 95%CI (95%CI=0. (p (95%CI=0 (95%CI= (95%CI

RESUMO Objetivo: Avaliar o efeito de diferentes materiais restauradores para uso em CAD-CAM na resistência à flexão biaxial após envelhecimento mecânico e térmico acelerado. Métodos: Foram fabricadas amostras (n=10) por grupo: CL (cerâmica reforçada com leucita: IPS Empress CAD) e NR (resina nanocerâmica: Lava Ultimate). A análise morfológica da superfície foi realizada por Microscopia Eletrônica de Varredura, e a análise química foi realizada por Espectroscopia de Raios X por Dispersão de Energia em uma amostra de cada grupo. Todas as amostras foram submetidas a envelhecimento acelerado, inicialmente através de ensaio de fadiga utilizando máquina mecânica de carregamento cíclico (200.000 ciclos, força 15N, 1Hz) em água destilada à temperatura (37°C). O envelhecimento térmico foi realizado em termociclador (5.000 ciclos, banhos de 5°C-55°C). Resultados: A análise estatística 1 Fator Anova (p<0,05) O grupo CL apresentou superfície mais difusa e quimicamente apresentou presença de Silício, Oxigênio, Alumínio, Sódio, Potássio e Cálcio. O grupo NR apresentava superfície mais compacta e continha os seguintes elementos químicos: Oxigênio, Silício, Carbono, Zircônio, Nitrogênio, Alumínio e Sódio. O CL (193,1MPa) apresentou valor de resistência mecânica superior ao NR (52,45MPa), o que foi estatisticamente significativo (p=0,000). Porém, o NR (2,3) apresentou menor média de fragmentos após fratura em relação ao CL (5,6). Conclusão: Os materiais restauradores exibiram morfologia e composição química distintas. Esses materiais restauradores tiveram um efeito estatisticamente significativo na resistência à flexão biaxial, sendo a cerâmica reforçada com leucita mecanicamente superior à resina nanocerâmica. E a família de resinas de matriz cerâmica apresentou menor quantidade de fragmentos após fratura em comparação ao material representativo da família vitrocerâmica. Objetivo CADCAM CAD CAM acelerado Métodos n=10 n10 n 10 (n=10 nanocerâmica Ultimate. Ultimate . Ultimate) Varredura 200.000 200000 200 000 (200.00 ciclos 15N N 1Hz Hz 37°C. 37C C 37°C 37 (37°C) 5.000 5000 5 (5.00 5°C55°C. 5C55C CC 5°C 55°C 55 5°C-55°C) Resultados p<0,05 p005 p 0 05 (p<0,05 Silício Oxigênio Sódio Cálcio químicos Carbono Zircônio Nitrogênio 193,1MPa 1931MPa MPa 193 1MPa (193,1MPa 52,45MPa, 5245MPa 52,45MPa , 52 45MPa (52,45MPa) p=0,000. p0000 p=0,000 (p=0,000) Porém 2,3 23 2 3 (2,3 5,6. 56 5,6 6 (5,6) Conclusão distintas vitrocerâmica n=1 n1 (n=1 200.00 20000 20 00 (200.0 (37°C 5.00 500 (5.0 C55 5°C55°C 5C 55C 5°C-55°C p<0,0 p00 (p<0,0 19 (52,45MPa p000 p=0,00 (p=0,000 2, (2, 5, (5,6 n= (n= 200.0 2000 (200. 5.0 50 (5. C5 p<0, p0 (p<0, p=0,0 (p=0,00 (2 (5, (n 200. (200 5. (5 p<0 (p<0 p=0, (p=0,0 ( (20 p< (p< p=0 (p=0, (p p= (p=0 (p=

ABSTRACT Objective: The aim of this study was to evaluate the effect of different restorative materials for use in CAD-CAM on biaxial flexural strength after accelerated mechanical and thermal aging. Methods: Samples were fabricated and divided into two groups: CL (leucite-reinforced ceramic: IPS Empress CAD) and NR (nanoceramic resin: Lava Ultimate). Morphological analysis of the surface was performed using Scanning Electron Microscopy, and chemical analysis was conducted using Energy Dispersive X-ray Spectroscopy on one sample from each group. All samples underwent accelerated aging, initially through fatigue testing using a mechanical cyclic loading machine (200,000 cycles, 15N force, 1Hz rotation speed) in distilled water at room temperature (37°C). Subsequently, thermal aging was carried out in a thermocycler (5,000 cycles, baths at 5°C and 55°C). Results: The CL group exhibited a more diffuse surface, and chemically, it showed the presence of Silicon, Oxygen, Aluminum, Sodium, Potassium, and Calcium. The NR group had a more compact surface and contained the following chemical elements: Oxygen, Silicon, Carbon, Zirconium, Nitrogen, Aluminum, and Sodium. The CL (193.1MPa) showed a higher mechanical strength value than the NR (52.45MPa), which was statistically significant. However, the NR (2.3) exhibited a lower average number of fragments after fracture compared to the CL (5.6). Conclusion: Restorative materials exhibited distinct morphology and chemical composition. These restorative materials had a statistically significant effect on biaxial flexural strength, with leucite-reinforced ceramics being mechanically superior to nanoceramic resin. And the ceramic matrix resin family showed a lower quantity of fragments after fracture compared to the material representing the glass-ceramic family. Objective CADCAM CAD CAM Methods groups leucitereinforced leucite reinforced Ultimate. Ultimate . Ultimate) Microscopy Xray X ray 200,000 200000 200 000 (200,00 cycles N force Hz speed 37°C. 37C C 37°C 37 (37°C) Subsequently 5,000 5000 5 (5,00 5C 55°C. 55C 55°C 55 55°C) Results chemically Silicon Oxygen Aluminum Sodium Potassium Calcium elements Carbon Zirconium Nitrogen 193.1MPa 1931MPa MPa 193 1MPa (193.1MPa 52.45MPa, 5245MPa 52.45MPa , 52 45MPa (52.45MPa) However 2.3 23 2 3 (2.3 5.6. 56 5.6 6 (5.6) Conclusion composition glassceramic glass 200,00 20000 20 00 (200,0 (37°C 5,00 500 (5,0 19 (52.45MPa 2. (2. 5. (5.6 200,0 2000 0 (200, 5,0 50 (5, 1 (2 (5. 200, (200 5, (5 ( (20

Abstract This study presents a novel approach to obtaining nano-antimicrobial hybrid material by integrating electrospun nanofibers based on cellulosic biopolymer (BP) associated with antimicrobial agents, specifically silver nanoparticles (AgNPs) and Clavanin A (ClavA), an antimicrobial peptide obtained from the marine tunicate Styela clava. The electrospinning technique produced the blended polyvinyl alcohol:BP nanofibers. Chemical crosslinking was performed to ensure the stability of the nanofibers. The nanofibers had an average diameter of 568 nm for PVA nanofibers and 648 nm for PVA nanofibers functionalized with silver nanoparticles. The nanohybrid material demonstrates significant inhibition zones against Gram-positive (Bacillus subtilis, Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa, Klebsiella pneumoniae) bacteria. P. aeruginosa exhibits a substantial inhibition zone of 15 mm. Thus, the nanohybrid material was effective against this challenging pathogen. Combining electrospun nanofibers, bacterial cellulose hydrogel, and antimicrobial agents establishes a solution that could combat microbial threats in wound care. nanoantimicrobial nano BP (BP AgNPs (AgNPs ClavA, ClavA , (ClavA) clava alcoholBP alcohol 56 64 Grampositive Gram positive Bacillus subtilis aureus Gramnegative negative Pseudomonas pneumoniae bacteria P 1 mm Thus pathogen hydrogel care (ClavA 5 6

Resumo Objetivou-se analisar os fatores associados ao policonsumo de álcool, tabaco e drogas ilícitas, entre adolescentes escolares brasileiros de 13 a 17 anos. Estudo transversal, com dados da Pesquisa Nacional de Saúde do Escolar (2019). A variável desfecho foi o relato de consumo das três substâncias nos últimos 30 dias. As variáveis independentes foram agrupadas em quatro blocos: características sociodemográficas; contexto familiar; situações estressoras; aspectos comportamentais. Foi realizada análise de regressão logística múltipla hierarquizada, permanecendo no modelo final as variáveis com p<0,05. A prevalência de policonsumo em adolescentes escolares foi 3,3%. No modelo final, sexo masculino, morar na região Centro-Oeste, Sul e Sudeste, faltar a escola sem permissão, pais não saberem o que fazem no tempo livre, ter pais fumantes, sofrer agressão física pelos pais, sentir que a vida não vale a pena ser vivida, experimentar bebida alcoólica e drogas ilícitas antes dos 13 anos, ter amigos que bebem bebida alcoólica, fumam e usam drogas na sua presença permaneceram associados ao desfecho. Os dados mostram alta prevalência de policonsumo de três substâncias entre adolescentes e sua associação a fatores sociodemográficos, familiares, comportamentais e a eventos estressantes. Objetivouse Objetivou se álcool 1 anos transversal 2019. 2019 . (2019) 3 dias blocos sociodemográficas familiar estressoras hierarquizada p005 p 0 05 p<0,05 33 3,3% masculino CentroOeste, CentroOeste Centro Oeste, Oeste Centro-Oeste Sudeste permissão livre fumantes vivida sociodemográficos familiares estressantes 201 (2019 p00 p<0,0 3,3 20 (201 p0 p<0, 3, 2 (20 p<0 (2 p< (

Abstract The aim of this study was to analyze the factors associated with concurrent alcohol, tobacco and illicit drug use among Brazilian schoolchildren aged 13-17. We conducted a cross-sectional study using data from the 2019 National School-Based Health Survey. The outcome was use of the three substances during the last 30 days. Hierarchical multiple logistic regression was carried out with independent variables grouped into four blocks: sociodemographic characteristics; family context; behavioral aspects; and stressors. Variables with p<0.05 were retained in the final model. The prevalence of concurrent substance use was 3.3%. Being male, living in the Midwest, South and Southeast, skipping school without parent permission, parents not knowing what their children do in their free time, having parents who smoke, having experienced physical aggression from parents, feeling that life is not worth living, trying drinking and illicit drugs before the age of 13, and having friends who drink alcohol, smoke and use drugs in their presence remained associated with the outcome in the final model. The findings reveal high prevalence of concurrent alcohol, cigarette and illicit drug use among adolescents and that poly use is associated with sociodemographic, family, and behavioral factors and stressors. alcohol 1317. 1317 13 17. 17 13-17 crosssectional cross sectional 201 SchoolBased School Based Survey 3 days blocks characteristics context aspects stressors p005 p 0 05 p<0.0 model 33 3.3% male Midwest Southeast permission time 131 1 13-1 20 p00 p<0. 3.3 13- 2 p0 p<0 3. p<

Abstract The objective of this study was to analyze the influence of insertion torque, bone type, and peri-implant bone loss on implant stability quotient (ISQ) of cylindrical external hexagon (EH) and Morse Taper (MT) implants. Forty-four single implants were placed in the edentulous areas of 20 patients who met the inclusion and exclusion criteria. Immediately after implant placement (t1) and after osseointegration (four and six months for mandible and maxilla, respectively) (t2), insertion torque, resonance frequency, and peri-implant bone loss were measured using probing depths and digital periapical radiography. A significant difference was noted in the ISQ values between t1 and t2 in type III bone for EH and MT implants. No significant difference in bone loss values was observed when comparing bone types for EH or MT in all evaluated sites. Based on marginal bone loss assessed using radiography, there was no significant difference between the MT and EH groups. A positive correlation between torque and ISQ t1 value was observed for MT (correlation: 0.439; p = 0.041) and EH (correlation: 0.461; p = 0.031) implants. For EH and MT implants, the greater the insertion torque, the greater was the ISQ value (moderately positive correlation). A weak negative correlation was found between bone type and ISQ t1 for MT implants. Contrarily, no correlation was observed between bone type and ISQ t1 for EH implants. In all cases, bone loss around the implants was clinically normal. periimplant peri (ISQ (EH (MT Fortyfour Forty four 2 criteria t (t1 maxilla respectively t2, , (t2) frequency radiography sites groups (correlation 0.439 0439 0 439 0.041 0041 041 0.461 0461 461 0.031 0031 031 moderately correlation. . correlation) Contrarily cases normal (t (t2 0.43 043 43 0.04 004 04 0.46 046 46 0.03 003 03 0.4 4 0.0 00 0.

Abstract In low and middle-income countries such as Brazil, most maternal deaths are related to hypertensive complications. Preeclampsia is the leading cause of maternal mortality and morbidity. Significant proportion is associated with the following factors: lack of identification of high-risk women, lack of adequate prevention, difficulty in maintaining a high-risk prenatal follow-up, delayed diagnosis, insecurity and low use of magnesium sulphate, delayed pregnancy interruption and lack of postpartum follow-up of these high-risk cases. Four major actions are proposed to minimize this alarming clinical picture and reduce the mortality rates due to preeclampsia, called the "4 P Rule" (Adequate Prevention – Vigilant Prenatal Care – Timely Delivery (Parturition) – Safe Postpartum). From this simple "rule" we can open a range of important processes and reminders that may help in the guidance of preeclampsia management. middleincome middle income Brazil complications morbidity factors highrisk high risk women prevention followup, followup follow up, up diagnosis sulphate cases 4 " Rule Adequate Parturition (Parturition Postpartum. Postpartum . Postpartum) rule "rule management

Resumo Fundamento: A adesão à uma alimentação adequada em macronutrientes é fundamental para a prevenção secundária de doenças cardiovasculares. Objetivo: Avaliar a prevalência de adesão às recomendações de consumo de ácidos graxos para prevenção e tratamento de doenças cardiovasculares, e estimar se a presença de determinados fatores de risco cardiovascular estaria associada à adesão. Métodos: Estudo transversal com os dados de linha de base de 2358 participantes do estudo "Brazilian Cardioprotective Nutritional Program Trial". Dados de consumo alimentar, e fatores de risco cardiovascular foram avaliados. Foi considerada, de acordo com a Sociedade Brasileira de Cardiologia, uma ingestão adequada de ácidos graxos poli-insaturados (AGPI) ≥10% do consumo total de energia diária, para ácidos graxos monoinsaturados (AGM), 20% e para ácidos graxos saturados (AGS), <7%. Na análise estatística foi considerando nível de significância de 5%. Resultados: Nenhum participante aderiu a todas as recomendações de forma simultânea e mais da metade (1482 [62,9%]) não aderiu a nenhuma recomendação. A adesão exclusivamente à recomendação de AGS foi a mais prevalente, sendo cumprida por 659 (28%) dos participantes, seguida da adesão exclusivamente à recomendação de AGP (178 [7,6%]) e de AGM (5 [0,2%]). Não houve associação entre o número de comorbidades e a adesão às recomendações nutricionais (p =0,269). Os participantes da região Nordeste do país apresentaram maior proporção de adesão às recomendações para consumo de AGS (38,42%), e menor para ingestão de AGPI (3,52%) (p <0,001) em comparação às demais. Conclusões: Na amostra avaliada, evidenciou-se baixa adesão às recomendações nutricionais para consumo de ácidos graxos. Fundamento cardiovasculares Objetivo Métodos 235 Brazilian Trial. Trial . Trial" alimentar avaliados considerada Cardiologia poliinsaturados poli insaturados (AGPI 10 ≥10 diária AGM, , (AGM) 20 AGS, (AGS) 7 <7% 5 5% Resultados 1482 (148 62,9% 629 62 9 [62,9%] prevalente 65 28% 28 (28% 178 (17 7,6% 76 6 [7,6%] ( 0,2%. 02 0,2% 0 2 [0,2%]) p =0,269. 0269 =0,269 269 =0,269) 38,42%, 3842 38,42% 38 42 (38,42%) 3,52% 352 3 52 (3,52% <0,001 0001 001 demais Conclusões avaliada evidenciouse evidenciou 23 1 ≥1 (AGM (AGS <7 148 (14 62,9 [62,9% (28 17 (1 7,6 [7,6% 0,2 [0,2%] 026 =0,26 26 384 38,42 4 (38,42% 3,52 35 (3,52 <0,00 000 00 ≥ < 14 62, [62,9 (2 7, [7,6 0, [0,2% =0,2 38,4 (38,42 3,5 (3,5 <0,0 [62, [7, [0,2 =0, 38, (38,4 3, (3, <0, [62 [7 [0, =0 (38, (3 <0 [6 [ [0 = (38

Background: Adhering to a diet adequate in macronutrients is crucial for the secondary prevention of cardiovascular diseases. Objective: To assess the prevalence of adherence to recommendations for the consumption of dietary fatty acids for the prevention and treatment of cardiovascular diseases and to estimate whether the presence of certain cardiovascular risk factors would be associated with adherence. Methods: Cross-sectional study using baseline data from 2,358 participants included in the "Brazilian Cardioprotective Nutritional Program Trial". Dietary intake and cardiovascular risk factors were assessed. Adequate intake of polyunsaturated fatty acids (PUFA) was considered as ≥10% of total daily energy intake; for monounsaturated fatty acids (MUFA), 20%; and for saturated fatty acids (SFA), <7% according to the Brazilian Society of Cardiology. A significance level of 5% was considered in the statistical analysis. Results: No participant adhered to all recommendations simultaneously, and more than half (1,482 [62.9%]) did not adhere to any recommendation. Adherence exclusively to the SFA recommendation was the most prevalent, fulfilled by 659 (28%) participants, followed by adherence exclusively to the PUFA (178 [7.6%]) and MUFA (5 [0.2%]) recommendations. There was no association between the number of comorbidities and adherence to nutritional recommendations (p = 0.269). Participants from the Brazilian Northeast region showed a higher proportion of adherence to SFA consumption recommendations (38.42%) and lower adherence to PUFA intake (3.52%) (p <0.001) compared to other regions. Conclusions: Among the evaluated sample, there was low adherence to nutritional recommendations for dietary fatty acid consumption. Background Objective Methods Crosssectional Cross sectional 2358 2 358 2,35 Trial. Trial . Trial" assessed (PUFA 10 ≥10 MUFA, , (MUFA) 20% 20 SFA, (SFA) 7 <7 Cardiology 5 analysis Results simultaneously 1,482 1482 1 482 (1,48 62.9% 629 62 9 [62.9%] prevalent 65 28% 28 (28% 178 (17 7.6% 76 6 [7.6%] ( 0.2% 02 0 [0.2%] p 0.269. 0269 0.269 269 0.269) 38.42% 3842 38 42 (38.42% 3.52% 352 3 52 (3.52% <0.001 0001 001 regions Conclusions sample 235 35 2,3 ≥1 (MUFA (SFA < 1,48 148 48 (1,4 62.9 [62.9% (28 17 (1 7.6 [7.6% 0.2 [0.2% 026 0.26 26 38.42 384 4 (38.42 3.52 (3.52 <0.00 000 00 23 2, ≥ 1,4 14 (1, 62. [62.9 (2 7. [7.6 0. [0.2 38.4 (38.4 3.5 (3.5 <0.0 1, [62. [7. [0. 38. (38. 3. (3. <0. [62 [7 [0 (38 (3 <0 [6 [

ABSTRACT Objective To evaluate the prevalence of burnout among the intensive care unit team of a university hospital after the second wave of COVID-19 and identify the key factors associated with its development. Methods This single-center study included 395 employees from a multidisciplinary team. The participants completed a questionnaire based on the Maslach Burnout Inventory. Multivariate analysis was used to identify the factors associated with burnout. Results Of 395 participants, 220 responded to the questionnaire (response rate: 56%). The prevalence of Burnout syndrome, defined as a severe score in at least one dimension, was 64.5% (142/220). Emotional distress was the most prevalent dimension, with a severe score affecting 50.5% (111/220) of the participants, followed by depersonalization at 39.1% (86/220). Only 5.9% (13/220) had severe scores in all three dimensions. Multivariate analysis revealed that being a physician was significantly associated with severe burnout symptoms in at least one dimension (odds ratio (OR), 1.32; 95% confidence interval (95%CI): 1.57-9.05; p=0.003). Additionally, having two or more jobs was associated with burnout in the three dimensions (OR=1.65; 95%CI=1.39-19.59; p=0.01). Conclusion This study highlights the alarming prevalence of burnout among intensive care unit teams, particularly among physicians, following the second wave of COVID-19. This emphasizes the need for targeted interventions and support systems to mitigate burnout and reduce its negative impact on healthcare professionals’ well-being and patient care. COVID19 COVID 19 COVID-1 development singlecenter single center 39 Inventory 22 response rate 56%. 56 56% . 56%) syndrome 645 64 5 64.5 142/220. 142220 142/220 142 (142/220) 505 50 50.5 111/220 111220 111 (111/220 391 1 39.1 86/220. 86220 86/220 86 (86/220) 59 9 5.9 13/220 13220 13 (13/220 odds OR, OR , (OR) 1.32 132 32 95 95%CI 95CI CI (95%CI) 1.579.05 157905 1.57 9.05 57 05 1.57-9.05 p=0.003. p0003 p p=0.003 0 003 p=0.003) Additionally OR=1.65 OR165 65 (OR=1.65 95%CI=1.3919.59 95CI1391959 95%CI=1.39 19.59 95%CI=1.39-19.59 p=0.01. p001 p=0.01 01 p=0.01) teams physicians COVID19. 19. professionals wellbeing well COVID1 COVID- 3 2 6 64. 14222 142/22 14 (142/220 50. 111/22 11122 11 (111/22 39. 8622 86/22 8 (86/220 5. 13/22 1322 (13/22 (OR 1.3 (95%CI 579 1.579.0 15790 157 1.5 905 9.0 1.57-9.0 p000 p=0.00 00 OR=1.6 OR16 (OR=1.6 3919 95%CI=1.3919.5 95CI139195 95CI139 95%CI=1.3 1959 19.5 95%CI=1.39-19.5 p00 p=0.0 1422 142/2 (142/22 111/2 1112 (111/2 862 86/2 (86/22 13/2 (13/2 1. 1.579. 1579 15 90 9. 1.57-9. OR=1. OR1 (OR=1. 95%CI=1.3919. 95CI13919 95CI13 95%CI=1. 195 95%CI=1.39-19. p0 p=0. 142/ (142/2 111/ (111/ 86/ (86/2 13/ (13/ 1.579 1.57-9 OR=1 (OR=1 95%CI=1.3919 95CI1391 95CI1 95%CI=1 95%CI=1.39-19 p=0 (142/ (111 (86/ (13 1.57- OR= (OR= 95%CI=1.391 95%CI= 95%CI=1.39-1 p= (142 (11 (86 (1 95%CI=1.39- (14 (8 (

ABSTRACT This study aims to investigate the possible association between neutrophil/lymphocyte and platelet/lymphocyte ratio in women with HIV, undergoing antiretroviral treatment, with HPV coinfection. This is a cross-sectional study with HIV positive women; their biological samples were collected for laboratory tests (complete blood count) and oncotic cytology for detection of HPV DNA, by PCR-Nested (PGMY and GP primers). Viral load and CD4 and CD8 T-cells counts were obtained from medical records. The data were analyzed, comparing the two groups: those with coinfection and those without it. From 82 HIV seropositive women, 50% exhibited HPV coinfection and 12.2% of coinfected patients had cervical cell alterations. Quantification of viral load, CD4 and CD8 T-cells count, CD4 / CD8 ratio and neutrophil/lymphocyte (NLR) and platelet/lymphocyte (PLR) ratio presented significant differences between groups (p<0.05). The predicting power of NLR and PLR in differentiating HIV/HPV coinfection which demonstrated differences between groups (AUC of 0.882 and 0.776 for NLR and PLR, respectively). There is a relation between the neutrophil/lymphocyte and platelet/lymphocyte ratio with HIV/HPV coinfection in women undergoing antiretroviral treatment, suggesting a state of greater and persistent systemic inflammation, reflecting as a biomarker for screening and monitoring these patients. neutrophillymphocyte neutrophil lymphocyte plateletlymphocyte platelet treatment crosssectional cross sectional complete count DNA PCRNested PCR Nested PGMY primers. primers . primers) CD Tcells T cells records analyzed it 8 50 122 12 2 12.2 alterations (NLR (PLR p<0.05. p005 p p<0.05 0 05 (p<0.05) HIVHPV AUC 0882 882 0.88 0776 776 0.77 respectively. respectively respectively) inflammation 5 1 12. p00 p<0.0 (p<0.05 088 88 0.8 077 77 0.7 p0 p<0. (p<0.0 08 0. 07 7 p<0 (p<0. p< (p<0 (p< (p