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au:Souza, Ana Maria Alves de

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Entre as ruas e a RAPS: Revisão integrativa sobre acesso das pessoas em situação de rua aos Serviços de Saúde Mental
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Fraga, Priscilla Victória Rodrigues

; Araújo, Maria Cecília Assis de

; Souza, Anelise Andrade de

; Martins, Ana Luísa Jorge

; Dantas, Ana Carolina de Moraes Teixeira Vilela

; Marinho, Rafaela Alves

; Rodrigues, Diadorim Maria

; Paes-Sousa, Rômulo

Ciência & Saúde Coletiva

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2025, Volume 30 N. 1 elocation e07752024

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Esta revisão integrativa sistematizou os fatores que influenciam o acesso da População em Situação de Rua (PSR) que faz uso prejudicial de álcool e outras drogas aos serviços de saúde mental na Rede de Atenção Psicossocial (RAPS) no Brasil, a partir da categorização dos fatores em “barreiras” e “facilitadores” de acesso. Selecionou-se 13 artigos correspondentes, com avaliação posterior de sua qualidade metodológica. Foram encontradas 19 barreiras e 22 facilitadores de acesso, observando uma convergência e complementaridade dos fatores identificados, sem dissensos entre autores. Embora existam barreiras e facilitadores específicos relacionados ao uso de substâncias, a maioria são vinculadas às condições e modos da vida da PSR, ou às formas dos serviços de lidar com a PSR. A discriminação, rigidez burocrática dos serviços, e a falta de integração intra e intersetorial foram identificadas como barreiras significativas. Por outro lado, os Consultórios na Rua e práticas como a redução de danos e o matriciamento emergiram como facilitadores notáveis, adaptando-se às necessidades dos usuários. Há necessidade de estudos futuros que se aprofundem em fatores específicos e nas relações entre estes fatores.

Abstract This integrative review systematized the factors that influence access to mental health services for the Homeless Population (HP) in harmful use of alcohol and other drugs in the Psychosocial Care Network (RAPS) in Brazil by categorizing the factors into access “barriers” and “facilitators”. We selected 13 corresponding articles and subsequently assessed their methodological quality. We identified 19 access barriers and 22 access facilitators, observing a convergence and complementarity of the factors identified, with no disagreements between authors. Although there are specific barriers and facilitators related to substance use, most are connected to HP’s conditions and lifestyles or how services address the HP. Discrimination, bureaucratic rigidity of services, and a lack of intra- and intersectoral integration were identified as significant barriers. On the other hand, Street Outreach Clinics and practices such as harm reduction and matrix-based support emerged as notable facilitators, adapting to patients’ needs. Future studies should explore specific factors and the relationships between these factors.

Resumen Esta revisión integradora sistematizó los factores que influyen en el acceso de la Población Sin Hogar (PSH) que hace uso nocivo de alcohol y otras drogas a los servicios de salud mental en la Red de Atención Psicosocial (RAPS) en Brasil, a partir de la categorización de factores en “barreras” y “facilitadores” del acceso. Se seleccionaron 13 artículos correspondientes, con posterior evaluación de su calidad metodológica. Se encontraron 19 barreras y 22 facilitadores de acceso, observándose una convergencia y complementariedad de los factores identificados, sin disensos entre autores. Aunque existen barreras y facilitadores específicos relacionados con el uso de sustancias, la mayoría están vinculados a las condiciones y estilos de vida de la PSH, o a las formas en que los servicios abordan la PSH. Se identificaron como barreras importantes la discriminación, la rigidez burocrática de los servicios y la falta de integración intra e intersectorial. Por otro lado, las Clínicas en la Calle y prácticas como la reducción de daños y el apoyo matricial emergieron como facilitadores notables, adaptándose a las necesidades de los usuarios. Es necesario realizar estudios futuros que profundicen en factores específicos y las relaciones entre estos factores.

https://doi.org/10.1590/1413-81232025301.07752024

Transformando práticas em modelo: caminhos para uma Rede de Atenção à Saúde da População em Situação de Rua
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Dantas, Ana Carolina de Moraes Teixeira Vilela

; Fernandes, Luísa da Matta Machado

; Martins, Ana Luísa Jorge

; Marinho, Rafaela Alves

; Rodrigues, Diadorim Maria

; Silva, Gabriela Drummond Marques da

; Souza, Anelise Andrade de

; Paes-Sousa, Rômulo

Ciência & Saúde Coletiva

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2025, Volume 30 N. 1 elocation e03102024

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo A População em Situação de Rua (PSR) apresentou um crescimento exponencial na última década acarretando diferentes desafios para o Sistema Único de Saúde, especialmente durante a pandemia de COVID-19. Estudo transversal, descritivo e exploratório, com triangulação de métodos quantitativos e qualitativos, de 2020 a 2022, que explorou as práticas de cuidado no município de Belo Horizonte voltadas à PSR. Na etapa quantitativa utilizou-se bancos oficiais das secretarias de saúde e assistência social, e na etapa qualitativa foram realizadas 48 entrevistas semiestruturadas e 4 grupos focais, totalizando 86 participantes. Os resultados apontam para a necessidade de uma Rede de Atenção à Saúde (RAS PSR) poliárquica e multiprofissional, com apoio intersetorial, orientada pela territorialização e longitudinalidade do cuidado, integrada aos sistemas de informação, visando a complexidade da abordagem e pautada na lógica da clínica ampliada. A atualização cadastral da PSR nos sistemas de saúde e qualificação dos serviços são cruciais para a eficácia da RAS PSR. Compreender a dinâmica das ações implementadas e/ou ampliadas no município e lições aprendidas localmente possibilita auxiliar na elaboração de políticas de cuidado efetivas.

Abstract The Homeless Population (HP) has grown exponentially in the last decade, causing different challenges for the Brazilian Unified Health System, especially during the COVID-19 pandemic. A cross-sectional, descriptive, and exploratory study, with triangulated quantitative and qualitative methods, was conducted from 2020 to 2022, exploring care practices geared to the HP in Belo Horizonte. The quantitative stage adopted official datasets from the health and social assistance secretariats, and 48 semi-structured interviews and four focus groups were conducted in the qualitative stage, totaling 86 participants. The results point to the need for implementing a polyarchic and multidisciplinary Healthcare Network (RAS-PSR) with intersectoral support, guided care territorialization and longitudinality integrated with information systems to address the complex approach and based on the logic of the expanded clinic. Updating HP records in health systems and qualifying services is needed to achieve RAS-PSR efficacy. Understanding the dynamics of actions developed or broadened by the municipality and lessons learned locally can assist the development of effective social care and health policies that can be upscaled to the national level.

Resumen La Población Sin Hogar (PSH) ha mostrado un crecimiento exponencial en la última década, provocando diferentes desafíos para el Sistema Único de Salud brasileño, especialmente durante la pandemia de COVID-19. Se ha implementado un estudio transversal, descriptivo y exploratorio con triangulación de métodos cuantitativos y cualitativos de 2020 a 2022, que exploró las prácticas de atención en la ciudad de Belo Horizonte dirigidas a la PSH. En la etapa cuantitativa se utilizaron bancos oficiales de las secretarías de salud y asistencia social, y se realizaron 48 entrevistas semiestructuradas y cuatro grupos focales en la etapa cualitativa, totalizando 86 participantes. Los resultados apuntan a la necesidad de una Red de Atención de Salud (RAS-PSR) poliárquica y multiprofesional, con apoyo intersectorial, orientada por la territorialización y longitudinalidad de la atención, integrada con sistemas de información, apuntando a la complejidad del abordaje y basada en la lógica de la clínica expandida. La actualización de los registros de la PSH en los sistemas de salud y los servicios de calificación son cruciales para la eficacia de la RAS-PSR. Comprender la dinámica de las acciones implementadas y/o ampliadas en el municipio y las lecciones aprendidas localmente permite coadyuvar en el desarrollo de políticas de cuidado efectivas y escalables a nivel nacional.

https://doi.org/10.1590/1413-81232025301.03102024

‘De repente, tudo fechou’: rede de cuidado à População em Situação de Rua na pandemia de covid-19 De repente fechou fechou’ covid19 covid 19 covid-1 covid1 1 covid-
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Marinho, Rafaela Alves

; Martins, Ana Luisa Jorge

; Souza, Anelise Andrade de

; Fernandes, Luísa da Matta Machado

; Dantas, Ana Carolina de Moraes Teixeira Vilela

; Oliveira, Ana Maria Caldeira

; Paes-Sousa, Rômulo

Saúde em Debate

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aug 2024, Volume 48 N. spe1 elocation e8554

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A pandemia de covid-19 se impôs de modo mais agudo e dramático aos grupos políticos e socialmente mais vulnerabilizados, como a População em Situação de Rua (PSR). A literatura sobre as respostas às demandas de saúde e de assistência social dos mais vulnerabilizados, durante a pandemia, ainda é escassa. Neste artigo, descreve-se a rede de cuidado à PSR, considerando os caminhos formalmente instituídos e aqueles produzidos durante a pandemia de covid-19, no município de Belo Horizonte. Para tanto, realizaram-se análise documental, visitas técnicas a serviços assistenciais, entrevistas em profundidade e grupos focais com atores que compõem a rede de cuidado. Os resultados mostraram que a rede é composta por quatro componentes com interseções: pela rede da saúde, da assistência social, da Pastoral Nacional do Povo da Rua (sociedade civil organizada) e a rede criada para cuidado de sintomáticos respiratórios. As mudanças de fluxos impostas pela pandemia repercutiram em dificuldades no acesso aos serviços de cuidado da PSR. Contudo, observou-se a potencialidade para a oferta da integralidade do cuidado, mediante articulações realizadas na pandemia entre a saúde, a assistência social e a sociedade civil organizada. covid19 covid 19 covid-1 vulnerabilizados PSR . (PSR) escassa artigo descrevese descreve covid19, 19, Horizonte tanto realizaramse realizaram documental assistenciais interseções organizada respiratórios Contudo observouse observou covid1 1 covid- (PSR

ABSTRACT The COVID-19 pandemic has imposed itself in a acutely and dramatically way, particularly on politically and socially vulnerable groups, such as the homeless population (HP). The literature on health emergency and response and social care needs of the most vulnerable during the pandemic is scarce. This article describes the network of care for HP, including formally instituted pathways of care and those produced during the pandemic of COVID-19, in the city of Belo Horizonte. The methodological path used documentary analysis, technical visits to care services, in-depth interviews and focus groups with the care network stakeholders. The results showed that the network is composed of four components with intersections: the health network, the social care network, the ‘National Pastoral Care of the Homeless People’ (non-governmental organization) and the network created to care for people with respiratory symptoms. The workflow changes imposed by the pandemic resulted in access barriers in different centers offering care for HP. However, it was observed the potentiality of the integral care offer, through the connections built during the pandemic between health, social care, and the non-governmental organizations. COVID19 COVID 19 COVID-1 way HP . (HP) scarce COVID19, 19, Horizonte analysis services indepth depth stakeholders intersections National People nongovernmental non governmental organization symptoms However offer organizations COVID1 1 COVID- (HP

https://doi.org/10.1590/2358-28982024e18554p

Consensus of the Brazilian Association of Hematology, Hemotherapy and Cellular Therapy (ABHH) and the Brazilian Ministry of Health - General management of blood and blood products on the tests necessary for the release of exceptional medicines for sickle cell disease Hematology ABHH (ABHH
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Lobo, Clarisse

; Araújo, Aderson Antunes, Alexandre de Albuquerque Pinto, Ana Cristina Silva Godinho, Ariadne Carvalho Pires, Cassia Silvestre Mariano Matheus, Cinthia Cristina Albuquerque, Xerez de Neves, Daniele Campos Fontes Moreno, Fábio de Lima Baldanzi, Giorgio Siufi, Grazziella Curado Miranda, Heloisa Helena Pereira Hankins, Jane Aragão, Joice Braga, Josefina Aparecida Pellegrini Martins, Juliana Touguinha Neves Souza, Luciana Campos Costa Machado de Figueiredo, Maria Stella Oliveira, Mirella Rodrigues Cardoso, Patricia Santos Resende Pinto, Patricia Costa Alves Moura, Patricia Gomes Cançado, Rodolfo Delfini Araujo, Paulo Ivo Cortez de Saad, Sara Olalla Loggetto, Sandra Regina Fonseca, Teresa Cristina Cardoso

Hematology, Transfusion and Cell Therapy

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mar 2024, Volume 46 N. 1 Pages 67 - 71

Abstract: En | Text: En | PDF: En

Abstract To date, hydroxyurea is the only effective and safe drug that significantly reduces morbidity and mortality of individuals with Sickle cell disease. Twenty years of real-life experience has demonstrated that hydroxyurea reduces pain attacks, vaso-occlusive events, including acute chest syndrome, the number and duration of hospitalizations and the need for transfusion. The therapeutic success of hydroxyurea is directly linked to access to the drug, the dose used and adherence to treatment which, in part, is correlated to the availability of hydroxyurea. This consensus aims to reduce the number of mandatory exams needed to access the drug, prioritizing the requesting physician's report, without affecting patient safety. date disease reallife real life attacks vasoocclusive vaso occlusive events syndrome transfusion which part physicians physician s report safety

https://doi.org/10.1016/j.htct.2024.01.001

Resin infiltrant with antibacterial activity: effects of incorporation of DMAHDM monomer and NACP on physical and antimicrobial properties activity
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SOUZA, Ana Ferreira

; FRAGA, May Anny Alves

; CORRER, Américo Bortolazzo

; AGUIAR, Flávio Henrique Baggio

; MARCHI, Giselle Maria

Journal of Applied Oral Science

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2024, Volume 32 elocation e20240263

Abstract: En | Text: En | PDF: En

Abstract Objectives Considering the fact that resin infiltrants lack antibacterial activity, this study assessed the influence of the quaternary ammonium monomer dimethylaminohexadecyl methacrylate (DMAHDM) and amorphous calcium phosphate nanoparticles (NACP) on the physical and antibacterial properties of an experimental resin infiltrant (ERI). Methodology The following groups were established: ERI (75/25 wt.% TEGDMA/BISEMA), ERI + 2.5% DMAHDM (2.5DM), ERI + 5% DMAHDM (5DM), ERI + 2% NACP (NACP), ERI + 2.5% DMAHDM + 2% NACP (2.5DM_NACP), ERI + 5% DMAHDM + 2% NACP (5DM_NACP), and Icon® (IC), a commercial resin infiltrant. Degree of conversion (DC; n=4), sorption and solubility (SO/SOL; n=8), and contact angle (CA; n=10) tests were conducted. Biofilm biomass (BB; n=6) and bacterial metabolism (BM; n=8) were evaluated after Streptococcus mutans (UA159) cultivation for 48 h on material samples. Data were evaluated by one-way ANOVA and Tukey or Games-Howell post hoc tests (α=0.05). Results IC exhibited the highest DC, with no difference from 2.5DM and 5DM. IC showed the lowest CA. IC had the lowest SO, followed by ERI, which had the lowest SOL, with no difference from IC. 5DM_NACP showed the lowest biofilm biomass, similar to 2.5DM and 5DM. Resin infiltrants containing DMAHDM showed reduced bacterial metabolism. Conclusions DMAHDM, with or without NACP, demonstrated significant antibacterial activity, while NACP impaired DC. Both DMAHDM and NACP increased the contact angle, sorption, and solubility of the resin infiltrant, which may affect the material’s clinical performance. activity (DMAHDM (NACP ERI. . (ERI) established 75/25 7525 75 25 (75/2 wt wt. TEGDMA/BISEMA, TEGDMABISEMA TEGDMA/BISEMA , TEGDMA BISEMA TEGDMA/BISEMA) 2 5 2.5 2.5DM, 25DM DM 5DM (2.5DM) 5DM, (5DM) 2.5DM_NACP, 25DMNACP DMNACP 2.5DM_NACP (2.5DM_NACP) 5DM_NACP, 5DMNACP (5DM_NACP) Icon IC, (IC) DC (DC n=4, n4 n n=4 4 n=4) SO/SOL SOSOL SO SOL (SO/SOL n=8, n8 n=8 8 CA (CA n=10 n10 10 conducted BB (BB n=6 n6 6 BM (BM UA159 UA (UA159 samples oneway one way GamesHowell Games Howell α=0.05. α005 α α=0.05 0 05 (α=0.05) materials s performance (ERI 75/2 752 7 (75/ 2. (2.5DM (5DM (2.5DM_NACP (5DM_NACP (IC n= n=1 n1 1 UA15 (UA15 α00 α=0.0 (α=0.05 75/ (75 UA1 (UA1 α0 α=0. (α=0.0 (7 (UA α=0 (α=0. ( α= (α=0 (α= (α

https://doi.org/10.1590/1678-7757-2024-0263

Vaccination coverage according to race or skin color in children born in 2017-2018 in Natal, Rio Grande do Norte, Brazil: a population survey 20172018 2017 2018 2017-201 Natal Norte Brazil 2017201 201 2017-20 201720 20 2017-2 20172 2 2017-
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Santos, Eliene Roberta Alves dos

; Barbosa, Isabelle Ribeiro

; Moraes, José Cássio de

; França, Ana Paula

; Domingues, Carla Magda Allan Santos

; Teixeira, Maria da Gloria

; Bezerra, Héllyda de Souza

; Medeiros, Nayre Beatriz Martiniano de

; Araújo, Mayonara Fabíola Silva

; Fernandes, Fábia Cheyenne Gomes de Morais

; Alexandrino, Arthur

; Bezerra, Ricardo Andrade

; Silva, Adriana Ilha da

; Ramos Jr., Alberto Novaes

; França, Ana Paula

; Oliveira, Andrea de Nazaré Marvão

; Boing, Antonio Fernando

; Domingues, Carla Magda Allan Santos

; Oliveira, Consuelo Silva de

; Maciel, Ethel Leonor Noia

; Guibu, Ione Aquemi

; Barbosa, Isabelle Ribeiro

; Barbosa, Jaqueline Caracas

; Lima, Jaqueline Costa

; Moraes, José Cássio de

; Luhm, Karin Regina

; Caetano, Karlla Antonieta Amorim

; Lima, Luisa Helena de Oliveira

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria da Gloria

; Teixeira, Maria Denise de Castro

; Borges, Maria Fernanda de Sousa Oliveira

; Queiroz, Rejane Christine de Sousa

; Gurgel, Ricardo Queiroz

; Barata, Rita Barradas

; Azevedo, Roberta Nogueira Calandrini de

; Oliveira, Sandra Maria do Valle Leone de

; Teles, Sheila Araújo

; Gama, Silvana Granado Nogueira da

; Mengue, Sotero Serrate

; Simões, Taynãna César

; Nascimento, Valdir

; Araújo, Wildo Navegantes de

Epidemiologia e Serviços de Saúde

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2024, Volume 33 N. spe2 elocation e20231310

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo Analisar a cobertura vacinal até os 24 meses de vida, segundo raça/cor da pele, na coorte de nascidos vivos em 2017-2018 em Natal, Rio Grande do Norte. Métodos Inquérito de base populacional realizado em 2020 e 2021. Estimaram-se as coberturas vacinais até os 24 meses de idade, segundo doses aplicadas, válidas e oportunas. A associação bruta da raça/cor da pele foi estimada pelo cálculo da razão de prevalência bruta e respectivos intervalos de confiança de 95% (IC95%), utilizando-se regressão de Poisson. Resultados Das 688 crianças da coorte selecionadas, houve maior cobertura entre as crianças negras para as doses aplicadas (brancas 30,5%; negras 47,8%; IC95%) e válidas (brancas 25,8%; negras 40,1%; IC95%), sem significância estatística, e menor cobertura para as doses oportunas, no esquema completo sem febre amarela (RP = 0,21; IC95% 0,04;0,90). Conclusão Evidenciou-se menor cobertura oportuna entre crianças negras, comparadas com crianças brancas. 2 vida raçacor raça cor 20172018 2017 2018 2017-201 Natal Norte 202 2021 Estimaramse Estimaram se idade oportunas 95 IC95%, IC95 IC , (IC95%) utilizandose utilizando Poisson 68 selecionadas brancas 30,5% 305 30 5 47,8% 478 47 8 25,8% 258 25 40,1% 401 40 1 estatística RP 0,21 021 0 21 0,040,90. 004090 0,04 0,90 . 04 90 0,04;0,90) Evidenciouse Evidenciou 2017201 201 2017-20 20 9 IC9 (IC95% 6 30,5 3 47,8 4 25,8 40,1 0,2 02 040 0,040,90 00409 004 0,0 090 0,9 0,04;0,90 201720 2017-2 (IC95 30, 47, 25, 40, 0, 0,040,9 0040 00 09 0,04;0,9 20172 2017- (IC9 0,040, 0,04;0, (IC 0,040 0,04;0 0,04;

ABSTRACT Objective To analyze vaccination coverage up to 24 months of age according to race/ skin color in the 2017-2018 live birth cohort in Natal, Rio Grande do Norte, Brazil. Methods Population-based survey conducted in 2020 and 2021. Vaccination coverage up to 24 months of age was estimated according to administered, valid and timely doses. Crude association of race/skin color was estimated by calculating the crude Prevalence Ratio and respective 95% Confidence Intervals, using Poisson regression. Results Of the 688 children in the selected cohort, there was greater coverage among Black children for administered doses (White 30.5%; Black 47.8%; 95%CI) and valid doses (White 25.8%; Black 40.1%; 95%CI), although without statistical significance, and lower coverage for timely doses, in the full schedule excluding yellow fever (PR = 0.21; 95%CI 0.04;0.90). Conclusion There was lower timely coverage among Black children compared to White children. 2 race 20172018 2017 2018 2017-201 Natal Norte Brazil Populationbased Population based 202 2021 raceskin 95 Intervals regression 68 30.5% 305 30 5 47.8% 478 47 8 95CI CI 25.8% 258 25 40.1% 401 40 1 95%CI, , significance PR 0.21 021 0 21 0.040.90. 004090 0.04 0.90 . 04 90 0.04;0.90) 2017201 201 2017-20 20 9 6 30.5 3 47.8 4 25.8 40.1 0.2 02 040 0.040.90 00409 004 0.0 090 0.9 0.04;0.90 201720 2017-2 30. 47. 25. 40. 0. 0.040.9 0040 00 09 0.04;0.9 20172 2017- 0.040. 0.04;0. 0.040 0.04;0 0.04;

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https://doi.org/10.1590/s2237-96222024v33e20231310.especial2.en

Safety of CoronaVac and ChAdOx1 vaccines against SARS-CoV-2 in patients with rheumatoid arthritis: data from the Brazilian multicentric study safer ChAdOx SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- arthritis SARS-CoV
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Cruz, Vitor Alves

; Guimarães, Camila Rêgo, Jozelia Machado, Ketty Lysie Libardi Lira Miyamoto, Samira Tatiyama Burian, Ana Paula Neves Dias, Laiza Hombre Pretti, Flavia Zon Batista, Danielle Cristina Filgueira Alves Mill, José Geraldo Oliveira, Yasmin Gurtler Pinheiro de Gadelha, Carolina Strauss Estevez Gouveia, Maria da Penha Gomes Moulin, Anna Carolina Simões Souza, Bárbara Oliveira Aguiar, Laura Gonçalves Rodrigues Vieira, Gabriel Smith Sobral Grillo, Luiza Lorenzoni Lima, Marina Deorce de Pasti, Laís Pizzol Surlo, Heitor Filipe Faé, Filipe Moulaz, Isac Ribeiro Macabú, Mariana de Oliveira Ribeiro, Priscila Dias Cardoso Magalhães, Vanessa de Oliveira Aguiar, Mariana Freitas de Biegelmeyer, Erika Peixoto;, Flávia Maria Matos Melo Campos Kayser, Cristiane Souza, Alexandre Wagner Silva de Castro, Charlles Heldan de Moura Ribeiro, Sandra Lúcia Euzébio Telles, Camila Maria Paiva França Bühring, Juliana Lima, Raquel Lima de Santos, Sérgio Henrique Oliveira Dos Dias, Samuel Elias Basualto Melo, Natália Seixas de Sanches, Rosely Holanda da Silva Boechat, Antonio Luiz Sartori, Natália Sarzi Hax, Vanessa Dória, Lucas Denardi Rezende, Rodrigo Poubel Vieira de Baptista, Katia Lino Fortes, Natália Rodrigues Querido Melo, Ana Karla Guedes de Melo, Tâmara Santos Vieira, Rejane Maria Rodrigues de Abreu Vieira, Adah Sophia Rodrigues Kakehasi, Adriana Maria Tavares, Anna Carolina Faria Moreira Gomes Landa, Aline Teixeira de Costa, Pollyana Vitoria Thomaz da Azevedo, Valderilio Feijó Martins-Filho, Olindo Assis Peruhype-Magalhães, Vanessa Pinheiro, Marcelo de Medeiros Monticielo, Odirlei André Reis-neto, Edgard Torres Dos Ferreira, Gilda Aparecida Souza, Viviane Angelina de Teixeira-Carvalho, Andréa Xavier, Ricardo Machado Sato, Emilia Inoue Valim, Valeria Pileggi, Gecilmara Salviato Silva, Nilzio Antonio da

Advances in Rheumatology

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2024, Volume 64 elocation 58

Abstract: En | Text: En | PDF: En

Abstract Background Patients with immune-mediated rheumatic diseases (IMRDs) have been prioritized for COVID-19 vaccination to mitigate the infection severity risks. Patients with rheumatoid arthritis (RA) are at a high risk of severe COVID-19 outcomes, especially those under immunosuppression or with associated comorbidities. However, few studies have assessed the safety of the COVID-19 vaccine in patients with RA. Objective To evaluate the safety of vaccines against SARS-CoV-2 in patients with RA. Methods This data are from the study “Safety and Efficacy on COVID-19 Vaccine in Rheumatic Diseases,” a Brazilian multicentric prospective phase IV study to evaluate COVID-19 vaccine in IMRDs in Brazil. Adverse events (AEs) in patients with RA of all centers were assessed after two doses of ChAdOx1 (Oxford/AstraZeneca) or CoronaVac (Sinovac/Butantan). Stratification of postvaccination AEs was performed using a diary, filled out daily and returned at the end of 28 days for each dose. Results A total of 188 patients with RA were include, 90% female. CoronaVac was used in 109 patients and ChAdOx1 in 79. Only mild AEs were observed, mainly after the first dose. The most common AEs after the first dose were pain at the injection (46,7%), headache (39,4%), arthralgia (39,4%), myalgia (30,5%) and fatigue (26,6%), and ChAdOx1 had a higher frequency of pain at the injection (66% vs 32 %, p < 0.001) arthralgia (62% vs 22%, p < 0.001) and myalgia (45% vs 20%, p < 0.001) compared to CoronaVac. The more common AEs after the second dose were pain at the injection (37%), arthralgia (31%), myalgia (23%), headache (21%) and fatigue (18%). Arthralgia (41,4% vs 25%, p = 0.02) and pain at injection (51,4% vs 27%, p = 0.001) were more common with ChAdOx1. No serious AEs were related. With Regard to RA activity level, no significant difference was observed between the three time periods for both COVID-19 vaccines. Conclusion In the comparison between the two immunizers in patients with RA, local reactions and musculoskeletal symptoms were more frequent with ChAdOx1 than with CoronaVac, especially after the first dose. In summary, the AE occurred mainly after the first dose, and were mild, like previous data from others immunizing agents in patients with rheumatoid arthritis. Vaccination did not worsen the degree of disease activity. immunemediated immune mediated (IMRDs COVID19 COVID 19 COVID-1 risks (RA outcomes comorbidities However SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- Safety Diseases, Diseases Brazil (AEs ChAdOx Oxford/AstraZeneca OxfordAstraZeneca Oxford AstraZeneca (Oxford/AstraZeneca Sinovac/Butantan. SinovacButantan Sinovac/Butantan . Sinovac Butantan (Sinovac/Butantan) diary 18 include 90 female 10 79 46,7%, 467 46,7% , 46 7 (46,7%) 39,4%, 394 39,4% 39 4 (39,4%) 30,5% 305 30 5 (30,5% 26,6%, 266 26,6% 26 6 (26,6%) 66% 66 (66 3 % 0.001 0001 0 001 62% 62 (62 22 22% 45% 45 (45 20 20% 37%, 37 37% (37%) 31%, 31 31% (31%) 23%, 23 23% (23%) 21% 21 (21% 18%. 18% (18%) 41,4% 414 41 (41,4 25 25% 0.02 002 02 51,4% 514 51 (51,4 27 27% related level summary COVID1 1 COVID- SARS-CoV (Sinovac/Butantan 9 46,7 (46,7% 39,4 (39,4% 30,5 (30,5 26,6 (26,6% (6 0.00 000 00 (4 (37% (31% (23% (21 (18% 41,4 (41, 0.0 51,4 (51, 46, (46,7 39, (39,4 30, (30, 26, (26,6 ( (37 (31 (23 (2 (18 41, (41 0. 51, (51 (46, (39, (30 (26, (3 (1 (5 (46 (39 (26

https://doi.org/10.1186/s42358-024-00397-5

A comprehensive physical functional assessment of survivors of critical care unit stay due to COVID-19 COVID19 COVID 19 COVID-1 COVID1 1 COVID-
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Volpe, Marcia Souza

; Santos, Ana Carolina Cardoso dos

; Gaspar, Sílvia

; Melo, Jade Lara de

; Harada, Gabriela

; Ferreira, Patrícia Rocha Alves

; Silva, Karina Ramiceli Soares da

; Souza, Natália Tiemi Simokomaki

; Toufen Junior, Carlos

; Chiavegato, Luciana Dias

; Amato, Marcelo Britto Passos

; Feltrim, Maria Ignez Zanetti

; Carvalho, Carlos Roberto Ribeiro de

Critical Care Science

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2024, Volume 36 elocation e20240284en

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Examinar a função física e a força muscular respiratória de pacientes que se recuperaram da COVID-19 grave após a alta da unidade de terapia intensiva para a enfermaria nos Dias 1 e 7 e investigar as variáveis associadas ao comprometimento funcional. Métodos: Trata-se de estudo de coorte prospectivo de pacientes adultos com COVID-19 que necessitaram de ventilação mecânica invasiva, ventilação mecânica não invasiva ou cânula nasal de alto fluxo e tiveram alta da unidade de terapia intensiva para a enfermaria. Os participantes foram submetidos aos testes Medical Research Council sum-score, força de preensão manual, pressão inspiratória máxima, pressão expiratória máxima e short physical performance battery. Os participantes foram agrupados em dois grupos conforme a necessidade de ventilação mecânica invasiva: o Grupo Ventilação Mecânica Invasiva (Grupo VMI) e o Grupo Não Ventilação Mecânica Invasiva (Grupo Não VMI). Resultados: Os pacientes do Grupo VMI (n = 31) eram mais jovens e tinham pontuações do Sequential Organ Failure Assessment mais altas do que os do Grupo VMI (n = 33). As pontuações do short physical performance battery (intervalo de zero a 12) nos Dias 1 e 7 foram 6,1 ± 4,3 e 7,3 ± 3,8, respectivamente para o Grupo Não VMI, e 1,3 ± 2,5 e 2,6 ± 3,7, respectivamente para o Grupo VMI. A prevalência de fraqueza adquirida na unidade de terapia intensiva no Dia 7 foi de 13% para o Grupo Não VMI e de 72% para o Grupo VMI. A pressão inspiratória máxima, a pressão expiratória máxima e a força de preensão manual aumentaram no Dia 7 em ambos os grupos, porém a pressão expiratória máxima e a força de preensão manual ainda eram fracas. Apenas a pressão inspiratória máxima foi recuperada (ou seja, > 80% do valor previsto) no Grupo Não VMI. As variáveis sexo feminino, e necessidade e duração da ventilação mecânica invasiva foram associadas de forma independente e negativa à pontuação do short physical performance battery e à força de preensão manual. Conclusão: Os pacientes que se recuperaram da COVID-19 grave e receberam ventilação mecânica invasiva apresentaram maior incapacidade do que aqueles que não foram ventilados invasivamente. No entanto, os dois grupos de pacientes apresentaram melhora funcional marginal durante a fase inicial de recuperação, independentemente da necessidade de ventilação mecânica invasiva. Esse resultado pode evidenciar a gravidade da incapacidade causada pelo SARS-CoV-2. Objetivo COVID19 COVID 19 COVID-1 Métodos Tratase Trata sumscore, sumscore sum score, score sum-score . Resultados n 31 33. 33 33) intervalo 12 61 6 6, 43 4 3 4, 73 7, 38 8 3,8 13 1, 25 2 5 2, 26 37 3,7 72 fracas seja 80 previsto feminino Conclusão invasivamente entanto recuperação SARSCoV2. SARSCoV2 SARSCoV SARS CoV 2. SARS-CoV-2 COVID1 COVID- 3, SARS-CoV- SARS-CoV

ABSTRACT Objective: To examine the physical function and respiratory muscle strength of patients - who recovered from critical COVID-19 – after intensive care unit discharge to the ward on Days one (D1) and seven (D7), and to investigate variables associated with functional impairment. Methods: This was a prospective cohort study of adult patients with COVID-19 who needed invasive mechanical ventilation, non-invasive ventilation or high-flow nasal cannula and were discharged from the intensive care unit to the ward. Participants were submitted to Medical Research Council sum-score, handgrip strength, maximal inspiratory pressure, maximal expiratory pressure, and short physical performance battery tests. Participants were grouped into two groups according to their need for invasive ventilation: the Invasive Mechanical Ventilation Group (IMV Group) and the Non-Invasive Mechanical Ventilation Group (Non-IMV Group). Results: Patients in the IMV Group (n = 31) were younger and had higher Sequential Organ Failure Assessment scores than those in the Non-IMV Group (n = 33). The short physical performance battery scores (range 0 - 12) on D1 and D7 were 6.1 ± 4.3 and 7.3 ± 3.8, respectively for the Non-Invasive Mechanical Ventilation Group, and 1.3 ± 2.5 and 2.6 ± 3.7, respectively for the IMV Group. The prevalence of intensive care unit-acquired weakness on D7 was 13% for the Non-IMV Group and 72% for the IMV Group. The maximal inspiratory pressure, maximal expiratory pressure, and handgrip strength increased on D7 in both groups, but the maximal expiratory pressure and handgrip strength were still weak. Only maximal inspiratory pressure was recovered (i.e., > 80% of the predicted value) in the Non-IMV Group. Female sex, and the need and duration of invasive mechanical were independently and negatively associated with the short physical performance battery score and handgrip strength. Conclusion: Patients who recovered from critical COVID-19 and who received invasive mechanical ventilation presented greater disability than those who were not invasively ventilated. However, they both showed marginal functional improvement during early recovery, regardless of the need for invasive mechanical ventilation. This might highlight the severity of disability caused by SARS-CoV-2. Objective COVID19 COVID 19 COVID-1 D (D1 D7, , (D7) impairment Methods noninvasive non highflow high flow sumscore, sumscore sum score, sum-score tests NonInvasive Non NonIMV . Results n 31 33. 33 33) range 12 61 6 1 6. 43 4 3 4. 73 7 7. 38 8 3.8 13 1. 25 2 5 2. 26 37 3.7 unitacquired acquired 72 weak i.e., ie i e (i.e. 80 value sex Conclusion ventilated However recovery SARSCoV2. SARSCoV2 SARSCoV SARS CoV SARS-CoV-2 COVID1 COVID- (D (D7 3. i.e. (i.e SARS-CoV- i.e SARS-CoV

https://doi.org/10.62675/2965-2774.20240284-en

How can we reduce maternal mortality due to preeclampsia? The 4P rule preeclampsia P
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Korkes, Henri Augusto

; Cavalli, Ricardo Carvalho

; Oliveira, Leandro Gustavo De

; Ramos, José Geraldo Lopes

; Martins Costa, Sérgio Hofmeister de Almeida

; Sousa, Francisco Lázaro Pereira de

; Vieira da Cunha Filho, Edson

; de Souza Mesquita, Maria Rita

; Dias Corrêa Júnior, Mário

; Pinheiro Fernandes Araújo, Ana Cristina

; Zaconeta, Alberto Carlos Moreno

; Freire, Carlos Henrique Esteves

; Poli de Figueiredo, Carlos Eduardo

; Rocha Filho, Edilberto Alves Pereira da

; Sass, Nelson

; Peraçoli, José Carlos

; Costa, Maria Laura

Revista Brasileira de Ginecologia e Obstetrícia

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2024, Volume 46 elocation e-rbgo43

Abstract: En | Text: En | PDF: En

Abstract In low and middle-income countries such as Brazil, most maternal deaths are related to hypertensive complications. Preeclampsia is the leading cause of maternal mortality and morbidity. Significant proportion is associated with the following factors: lack of identification of high-risk women, lack of adequate prevention, difficulty in maintaining a high-risk prenatal follow-up, delayed diagnosis, insecurity and low use of magnesium sulphate, delayed pregnancy interruption and lack of postpartum follow-up of these high-risk cases. Four major actions are proposed to minimize this alarming clinical picture and reduce the mortality rates due to preeclampsia, called the "4 P Rule" (Adequate Prevention – Vigilant Prenatal Care – Timely Delivery (Parturition) – Safe Postpartum). From this simple "rule" we can open a range of important processes and reminders that may help in the guidance of preeclampsia management. middleincome middle income Brazil complications morbidity factors highrisk high risk women prevention followup, followup follow up, up diagnosis sulphate cases 4 " Rule Adequate Parturition (Parturition Postpartum. Postpartum . Postpartum) rule "rule management

https://doi.org/10.61622/rbgo/2024rbgo43

10.

População em situação de rua: comunicação e (des)informação no contexto da pandemia de Covid-19 rua desinformação des informação Covid19 Covid 19 Covid-1 Covid1 1 Covid-
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Oliveira, Ana Maria Caldeira

; Dantas, Ana Carolina de Moraes Teixeira Vilela

; Souza, Anelise Andrade de

; Marinho, Rafaela Alves

; Martins, Ana Luísa Jorge

; Paes-Sousa, Rômulo

Interface - Comunicação, Saúde, Educação

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2024, Volume 28 elocation e230433

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

O estudo objetivou identificar os sentidos produzidos pela comunicação dirigida à população em situação de rua (PSR) durante a pandemia de Covid-19 na cidade de Belo Horizonte. Por meio da técnica de análise de conteúdo, analisaram-se 48 entrevistas realizadas com a PSR; gestores e trabalhadores do Sistema Único de Saúde e do Sistema Único de Assistência Social; e representantes da Pastoral do Povo da Rua e da Defensoria Pública. Cinco temáticas identificadas respaldam os resultados e a discussão: pandemia e seu surgimento; fechamento da cidade e consequências para PSR; desinformação e reprodução de estigmas; desinformação e vacinação; e infodemia. Os resultados indicaram que a comunicação relacionada à pandemia foi considerada como fator de menor importância no planejamento público, ocasionando impacto negativo no enfrentamento social da doença. Destaca-se a importância de estratégias de comunicação públicas, inclusivas, dialógicas – com identificação e escuta dos grupos populacionais vulneráveis – e adaptadas às suas necessidades. PSR (PSR Covid19 Covid 19 Covid-1 Horizonte conteúdo analisaramse analisaram se 4 Social Pública discussão surgimento estigmas vacinação infodemia público doença Destacase Destaca públicas inclusivas necessidades Covid1 1 Covid-

This study aimed to identify meanings produced by communication directed at the homeless population during the Covid-19 pandemic in Belo Horizonte. Forty-eight interviews with homeless people, Brazilian National Health System and Brazilian National Social Assistance System managers and workers, and representatives of the Pastoral Ministry for the Homeless and Public Defender’s Office were analyzed using content analysis. The results and discussion are structured around five core themes: the pandemic and its onset; closure of the city and the consequences for homeless people; disinformation and reproduction of stigmas; disinformation and vaccination; and the infodemic. The results suggest that communication related to the pandemic was seen as a minor factor in public planning that negatively impacted coping with the disease. The findings highlight the importance of identifying and listening to vulnerable groups and promoting inclusive and dialogical public communication strategies tailored to their specific needs. Covid19 Covid 19 Covid-1 Horizonte Fortyeight Forty eight people workers Defenders Defender s analysis themes onset stigmas vaccination infodemic disease needs Covid1 1 Covid-

El objetivo del estudio fue identificar los sentidos producidos por la comunicación dirigida a la Población que Vive en la Calle (PSR) durante la pandemia de Covid-19 en la ciudad de Belo Horizonte. Por medio de la técnica de análisis de contenido se analizaron 48 entrevistas realizadas con esa población, gestores y trabajadores del Sistema Brasileño de Salud y Sistema Brasileño de Asistencia Social, representantes de la Pastoral de la Población que vive en la Calle y la Defensoría Pública. Cinco temáticas identificadas respaldan los resultados y la discusión: la pandemia y su aparición; cierre de la ciudad y consecuencias para la Población que vive en la Calle; desinformación y reproducción de estigmas; desinformación y vacunación; e infodemia. Los resultados indicaron que la comunicación relacionada con la pandemia se consideró como factor de menor importancia en la planificación pública, ocasionando impacto negativo en el enfrentamiento social de la enfermedad. Se destaca la importancia de estrategias de comunicación públicas, incluyentes y dialógicas, con identificación y escucha de los grupos poblacionales vulnerables y adaptadas a sus necesidades. PSR (PSR Covid19 Covid 19 Covid-1 Horizonte 4 población Social Pública discusión aparición estigmas vacunación infodemia pública enfermedad públicas dialógicas necesidades Covid1 1 Covid-

https://doi.org/10.1590/interface.230433

11.

Kidney care in patients with cancer: perspectives from the onconephrology committee of the Brazilian Society of Nephrology cancer
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Brito, Germana Alves de

; Caires, Renato Antunes

; Coelho, Fernanda Oliveira

; Campos, Mariana Fontes Turano

; Cunha, Danielle Figueiredo da

; Costalonga, Elerson Carlos

; Pereira, Benedito Jorge

; Durão Júnior, Marcelino de Souza

; Amorim, Fernanda

; Santos, Ana Maria Emrich dos

; Guedes, Felipe Leite

; Silva, Verônica Torres Costa e

Revista da Associação Médica Brasileira

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2024, Volume 70 Suppl. 1 elocation e2024S121

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/1806-9282.2024s121

12.

Factors associated with vaccination coverage in children up to 15 months old, born in 2017-2018 in the city of Natal/RN, Brazil: a population-based survey 1 old 20172018 2017 2018 2017-201 NatalRN Natal RN Natal/RN Brazil populationbased population based 2017201 201 2017-20 201720 20 2017-2 20172 2 2017-
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Medeiros, Nayre Beatriz Martiniano de

; Barbosa, Isabelle Ribeiro

; Barata, Rita Barradas

; França, Ana Paula

; Guibu, Ione Aquemi

; Moraes, José Cássio de

; Domingues, Carla Magda Allan Santos

; Teixeira, Maria da Gloria

; Souza, Ana Clara Dantas de

; Santos, Eliene Roberta Alves Dos

; Araújo, Mayonara Fabíola Silva

; Pereira, Clebson Verissimo da Costa

; Bezerra, Ricardo Andrade

; Alexandrino, Arthur

; Fernandes, Fábia Cheyenne Gomes de Morais

; Silva, Adriana Ilha da

; Ramos Jr., Alberto Novaes

; França, Ana Paula

; Oliveira, Andrea de Nazaré Marvão

; Boing, Antonio Fernando

; Domingues, Carla Magda Allan Santos

; Oliveira, Consuelo Silva de

; Maciel, Ethel Leonor Noia

; Guibu, Ione Aquemi

; Mirabal, Isabelle Ribeiro Barbosa

; Barbosa, Jaqueline Caracas

; Lima, Jaqueline Costa

; Moraes, José Cássio de

; Luhm, Karin Regina

; Caetano, Karlla Antonieta Amorim

; Lima, Luisa Helena de Oliveira

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria da Gloria

; Teixeira, Maria Denise de Castro

; Borges, Maria Fernanda de Sousa Oliveira

; Queiroz, Rejane Christine de Sousa

; Gurgel, Ricardo Queiroz

; Barata, Rita Barradas

; Azevedo, Roberta Nogueira Calandrini de

; Oliveira, Sandra Maria do Valle Leone de

; Teles, Sheila Araújo

; Gama, Silvana Granado Nogueira da

; Mengue, Sotero Serrate

; Simões, Taynãna César

; Nascimento, Valdir

; Araújo, Wildo Navegantes de

Epidemiologia e Serviços de Saúde

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2024, Volume 33 N. spe2 elocation e20231307

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo Estimar as coberturas vacinais e analisar os fatores associados à vacinação completa de crianças com até 15 meses de vida em Natal, Rio Grande do Norte. Métodos Utilizou-se inquérito de base populacional com dados registrados na caderneta de vacinação e entrevistas realizadas em 2020 e 2021. A análise de fatores associados à vacinação completa foi realizada pelo cálculo das razões de prevalência (RP) e intervalos de confiança de 95% (IC95%) pela regressão de Poisson. Resultados Entre as 688 crianças estudadas, a cobertura vacinal foi de 45,4% (IC95% 37,2;53,9), e de 15,5% (IC95% 10,6;22,2) para as doses válidas e oportunas. O sexo feminino (RP=1,08; IC95% 0,78;1,48) e os estratos socioeconômicos C e D (RP=1,44; IC95% 1,03;2,02) foram os que tiveram a maior cobertura vacinal. Conclusões Os resultados mostraram baixas coberturas vacinais para todos os imunobiológicos em Natal. 1 Natal Norte Utilizouse Utilizou se 202 2021 RP (RP 95 IC95 IC Poisson 68 estudadas 454 45 4 45,4 (IC95 37,253,9, 372539 37,2 53,9 , 37 2 53 9 37,2;53,9) 155 5 15,5 10,622,2 106222 10,6 22,2 10 6 22 10,6;22,2 oportunas RP=1,08 RP108 08 (RP=1,08 0,781,48 078148 0,78 1,48 0 78 48 0,78;1,48 RP=1,44 RP144 44 (RP=1,44 1,032,02 103202 1,03 2,02 03 02 1,03;2,02 20 IC9 45, (IC9 253 37,253,9 37253 372 37, 539 53, 3 37,2;53,9 15, 622 10,622, 10622 106 10, 222 22, 10,6;22, RP=1,0 RP10 (RP=1,0 781 0,781,4 07814 078 0,7 148 1,4 7 0,78;1,4 RP=1,4 RP14 (RP=1,4 032 1,032,0 10320 103 1,0 2,0 1,03;2,0 (IC 25 37,253, 3725 37,2;53, 62 10,622 1062 10,6;22 RP=1, RP1 (RP=1, 0,781, 0781 07 0, 14 1, 0,78;1, 1,032, 1032 2, 1,03;2, 37,253 37,2;53 10,62 10,6;2 RP=1 (RP=1 0,781 0,78;1 1,032 1,03;2 37,25 37,2;5 10,6; RP= (RP= 0,78; 1,03; 37,2;

ABSTRACT Objective To estimate vaccination coverage and analyze factors associated with full vaccination among children up to 15 months old in the city of Natal-RN, Brazil. Methods Population-based survey with data recorded on children’s vaccination cards and interviews conducted in 2020 and 2021. Analysis of factors associated with complete vaccination was performed by calculating prevalence ratios (PR) and 95% confidence intervals (95%CI) using Poisson regression. Results Among 688 children studied, vaccination coverage was 45.4% (95%CI 37.2;53.9) and 15.5% (95%CI 10.6;22.2) for valid and on-time doses, respectively. Higher vaccination coverage was associated with females (PR=1.08; 95%CI 0.78;1.48) and socioeconomic strata C and D (PR=1.44; 95%CI 1.03;2.02). Conclusions The results demonstrate that the city of Natal has low vaccination coverage for all immunobiologicals. 1 NatalRN, NatalRN RN, RN Natal-RN Brazil Populationbased Population based childrens s 202 2021 PR (PR 95 95CI CI regression 68 studied 454 45 4 45.4 37.253.9 372539 37.2 53.9 37 2 53 9 37.2;53.9 155 5 15.5 10.622.2 106222 10.6 22.2 10 6 22 10.6;22.2 ontime time doses respectively PR=1.08 PR108 08 (PR=1.08 0.781.48 078148 0.78 1.48 0 78 48 0.78;1.48 PR=1.44 PR144 44 (PR=1.44 1.032.02. 103202 1.03 2.02 . 03 02 1.03;2.02) immunobiologicals 20 45. 253 37.253. 37253 372 37. 539 53. 3 37.2;53. 15. 622 10.622. 10622 106 10. 222 22. 10.6;22. PR=1.0 PR10 (PR=1.0 781 0.781.4 07814 078 0.7 148 1.4 7 0.78;1.4 PR=1.4 PR14 (PR=1.4 032 1.032.02 10320 103 1.0 2.0 1.03;2.02 25 37.253 3725 37.2;53 62 10.622 1062 10.6;22 PR=1. PR1 (PR=1. 0.781. 0781 07 0. 14 1. 0.78;1. 1.032.0 1032 2. 1.03;2.0 37.25 37.2;5 10.62 10.6;2 PR=1 (PR=1 0.781 0.78;1 1.032. 1.03;2. 37.2; 10.6; PR= (PR= 0.78; 1.032 1.03;2 1.03;

resumen está disponible en el texto completo

https://doi.org/10.1590/s2237-96222024v33e20231307.especial2.en

13.

Effect of curcumin and three analogues on pre-osteoblast cells’ viability, differentiation, and gene expression preosteoblast pre osteoblast cells viability differentiation
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Sá, Ana Flor

; Diniz, Ivana Márcia Alves

; Oliveira, Renata Barbosa de

; Diniz, Marina Gonçalves

; Cortés, Maria Esperanza

; Souza, Letícia Lopes de

; Olórtegui, Carlos Delfin Chávez

; Lages, Frederico Santos

Brazilian Oral Research

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2024, Volume 38 elocation e123

Abstract: En | Text: En | PDF: En

Abstract Curcumin, found in turmeric rhizomes (Curcuma longa L.), has been widely studied for its potential health benefits, including anti-inflammatory, antioxidant, and wound-healing properties. However, due to its low bioavailability and unfavorable pharmacokinetics, analogous compounds have been developed to obtain better biopharmaceutical characteristics and enhanced biological effects. In this study, we evaluated the activity of curcumin and three of its synthetic analogues (DMAD, DMAM, and RI75) on the viability and differentiation of a pre-osteoblastic cell line (MC3T3-E1). We also assessed the expression of key genes involved in tissue regeneration: vascular endothelial growth factor (vegf), stromal-derived growth factor 1 (SDF-1/CXCL12), and runt-related transcription factor 2 (runx2). The cells were treated with curcumin and the three analogues at concentrations of 10, 30, or 50 μM. All tested analogues and curcumin exhibited moderate to no cell toxicity compared to the cells treated under standard conditions across all concentrations after 24, 48, and 72 hours. Only the RI75 analogue showed upregulation of SDF-1, a crucial factor in tissue regeneration. Compared to curcumin, the DMAM and RI75 analogues also upregulated runx2 and vegf, both associated with osteodifferentiation. The RI75 analogue demonstrated greater mineralization than curcumin, and both promoted more nodule formation than the untreated control. Our data suggest that the curcumin analogue RI75 at 50 μM presents similar toxicity but enhanced biological activity compared to natural curcumin, making it a promising substance for material biomodifications. Curcumin Curcuma L., L L. , L.) benefits antiinflammatory, antiinflammatory anti inflammatory, inflammatory anti-inflammatory antioxidant woundhealing wound healing properties However pharmacokinetics effects study DMAD, DMAD (DMAD RI preosteoblastic pre osteoblastic MC3T3E1. MC3T3E1 MCTE MC3T3 E1 . MC T E (MC3T3-E1) regeneration vegf (vegf) stromalderived stromal derived SDF1/CXCL12, SDF1CXCL12 SDFCXCL SDF 1/CXCL12 CXCL12 CXCL (SDF-1/CXCL12) runtrelated runt related runx2. runx (runx2) 10 30 5 24 48 7 hours RI7 SDF1, SDF1 1, SDF-1 osteodifferentiation control biomodifications MC3T3E MCT MC3T (MC3T3-E1 (vegf SDF1/CXCL12 SDF1CXCL1 1CXCL12 1/CXCL1 CXCL1 (SDF-1/CXCL12 (runx2 3 4 SDF- (MC3T3-E SDF1/CXCL1 SDF1CXCL 1CXCL1 1/CXCL (SDF-1/CXCL1 (runx SDF1/CXCL 1CXCL (SDF-1/CXCL

https://doi.org/10.1590/1807-3107bor-2024.vol38.0123

14.

COVID-Inconfidentes - SARS-CoV-2 seroprevalence in two Brazilian urban areas in the fourth quarter 2020: study protocol and initial results
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Meireles, Adriana Lúcia

; Garcia Lourenção, Luciano

; Alves de Menezes Júnior, Luiz Antônio

; Nascimento Coletro, Hillary

; Sousa Justiniano, Irene Carolina

; Silva de Moura, Samara

; Popolino Diniz, Amanda

; da Silva Sabião, Thaís

; Sampaio Rocha, Ana Maria

; Batista, Aline Priscila

; Nunes Lage, Nara

; dos Santos Simões, Bárbara

; Ali Santos, Carolina

; de Deus Mendonça, Raquel

; de Souza Andrade, Amanda Cristina

; Furbino Barbosa, Keila

; Zumerle Masioli, Cássio

; Cardoso Carraro, Júlia Cristina

; Carvalho de Menezes, Mariana

; Rezende Macedo Nascimento, Renata Cristina

; Roever, Leonardo

; Teixeira Caiaffa, Waleska

; Lins Machado Coelho, George Luiz

Población y Salud en Mesoamérica

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dec 2023, Volume 21 N. 1 Pages 15 - 37

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Describir el protocolo de estudio y los resultados iniciales del proyecto de investigación COVID Inconfidentes. Método: Este artículo describe los procedimientos metodológicos adoptados y la prevalencia de la infección por SARS-CoV-2 en la población. Se realizó una encuesta domiciliaria entre octubre y diciembre de 2020, en dos ciudades históricas de la región minera de Brasil. El anticuerpo anti-SARS-CoV-2 se detectó mediante la prueba rápida Wondfo®. La entrevista cara a cara consistió en la administración de un cuestionario que contenía datos de registro, variables sociodemográficas y económicas, hábitos de vida, estado general de salud, salud mental, hábitos de sueño, alimentación y nutrición. Resultados: Se evaluaron 1.762 habitantes, de los cuales 764 (43,4 %) estaban en Mariana y 998 (56,6 %) en Ouro Preto. Para ambas ciudades, el 51,9 % de los entrevistados eran del sexo femenino, con predominio del rango de edad de 35 a 59 años (47,2 %). La prevalencia de la infección por SARS-CoV-2 fue del 5,5 % en ambos municipios, del 6,2 % en Ouro Preto y del 4,7 % en Mariana (p > 0,05). Conclusión: El estudio fue efectivo para estimar la seroprevalencia de infección por el virus y sus hallazgos permitirán analizar más las condiciones de salud de la población relacionadas con el aislamiento social y el riesgo de infección por SARS-CoV-2.

Abstract Objective: To describe study protocol and initial results of research project COVID-Inconfidentes. Method: This paper described the methodological procedures adopted and the prevalence of the SARS-CoV-2 infection in the population. A household survey was conducted between October and December 2020, in two historic cities of Brazil's mining region. Anti-SARS-CoV-2 antibody was detected using the Wondfo® rapid test. The face-to face interview consisted of administration of a questionnaire containing registration data, sociodemographic and economic variables, living habits, general health condition, mental health, sleep habits, and eating and nutrition. Results: We evaluated 1,762 residents, of which 764 (43.4 %) were in Mariana and 998 (56.6 %) in Ouro Preto. For both cities, 51.9 % of the interviewees were female, with a predominance of the age range 35 to 59 years old (47.2 %). The prevalence of the SARS-CoV-2 infection was 5.5 % in both cities, 6.2 % in Ouro Preto, and 4.7 % in Mariana (p-value > 0.05). Conclusion: The study was effective to estimate the seroprevalence of infection by the virus and its findings will enable further analyses of the health conditions of the population related to social isolation and the risk of infection with SARS-CoV-2.

https://doi.org/10.15517/psm.v21i1.53127

15.

Estudo do nível de atividade física, grau de resiliência e risco coronariano de acadêmicos do curso de Educação Física da Universidade do Estado do Pará
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Souza, Divaldo Martins de

; Saraiva, Arianne Camile Silva

; Dias, Letícia Alves

; Rocha, Ana Vitória Travassos

; Luz, Lorenzo Marcley Ramos

; Silva, Jennifer Fabiana Santos da

Motricidade

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sep 2023, Volume 19 N. 3 Pages 351 - 357

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Physical Activity (PA) is a predictive factor of diseases and health promotion. Resilience (R) is a positive reaction in the face of a catastrophe, threat or stressful situation, and coronary risk (CR) is important in the study of health. This study aimed to analyse and correlate the levels of PA, R and CR in the students of the Physical Education Course of the UEPA. In addition to the field, analytic, comparative and correlational, conducted from March to May 2022 with 60 students, the data were collected through the Baecke PA Level Questionnaire, the R Scale questionnaire and the UFSM RC assessment questionnaire, treated using absolute and relative values, mean and standard deviation, χ2 test, Student t, ANOVA one way and Pearson correlation. The results indicate a higher prevalence of Good Grade of R, Level of Regular PA and Level of Remote CR, higher PA index in women and CR in men, correlation between age and R and negative between PA and CR, which suggests adequate R and CR, but lower PA; men need to improve their PA and decrease CR.

RESUMO Atividade Física (AF) é fator preventivo de doenças e de promoção de saúde. Resiliência (R) é reação positiva diante de uma catástrofe, ameaça ou situação estressante e risco coronariano (RC) é importante no estudo da saúde. O objetivo do estudo foi analisar e correlacionar os níveis de AF, R e RC nos acadêmicos do Curso de Educação Física da UEPA. Estudo de campo, analítico, comparativo e correlacional, realizado de março a maio de 2022 com 60 acadêmicos. Os dados foram coletados através do Questionário de Nível de AF de Baecke, Burema e Frijters (1982), do questionário da Escala de R adaptado por Pesce et al. (2005) e do questionário de avaliação do RC da Universidade Federal de Santa Maria (2000), tratados através dos valores absolutos e relativos, média e desvio padrão, teste χ2, t de Student, ANOVA one way e correlação de Pearson. Os resultados indicam maior prevalência de grau Bom de R, nível de AF Regular e nível de RC Remoto, índice de AF maior nas mulheres e RC nos homens, correlação entre a idade e R e negativa entre a AF e o RC, o que sugere R e RC adequados, porém AF inferior; os homens precisam melhorar sua AF e diminuir o RC.

https://doi.org/10.6063/motricidade.31564

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