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Impact of a research-action on vaccination indicators in the state of Minas Gerais, Brazil
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Souza, Janaina Fonseca Almeida

; Silva, Thales Philipe Rodrigues da

; Oliveira, Thais Moreira

; Vimieiro, Aline Mendes

; Teixeira, Antônia Maria da Silva

; Soares, Adriana Coelho

; Ribeiro, Elice Eliane Nobre

; Freitas, Giselle Lima de

; Gaspar, Eduarda Dantas

; Matozinhos, Fernanda Penido

Revista de Saúde Pública

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2024, Volume 58 elocation 09

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO OBJETIVO Analisar o impacto do projeto estadual de pesquisa-ação nos indicadores de imunização (coberturas vacinais – CV, homogeneidade de cobertura vacinal – HCV, taxa de abandono – TA e classificação de risco) antes e após a intervenção em municípios e Gerências Regionais de Saúde/Superintendências Regionais de Saúde (GRS/SRS) prioritários. MÉTODOS O projeto estadual de pesquisa-ação foi um ensaio clínico comunitário, do tipo antes-depois, realizado em 212 municípios pertencentes a oito GRS/SRS do estado de Minas Gerais, Brasil. Compuseram a amostra do estudo as SRS/GRS com tendência decrescente para a cobertura vacinal de rotina em crianças menores de 1 ano, no período de 2015 a 2020. Neste estudo, foram utilizados dados secundários de CV e TA de 10 imunobiológicos recomendados para crianças menores de 2 anos, no período de janeiro a dezembro de 2021 (período pré-intervenção, anterior ao projeto estadual de pesquisa-ação) e de janeiro a dezembro de 2022 (período pós-intervenção). As variáveis categóricas foram apresentadas em proporções e, inicialmente, realizou-se a comparação entre as de TA, HCV e a classificação de risco para a transmissão de doenças imunopreveníveis, segundo os dois períodos (2021 e 2022), utilizando-se o teste McNemar. RESULTADOS Observou-se um aumento de todos os indicadores de imunização após a realização do projeto de pesquisa-ação. No ano de 2021, 80,66% dos municípios do estado tiveram a classificação de risco para transmissão de doenças imunopreveníveis como “alto e muito alto risco”. Em 2022, o valor foi reduzido para 68,40%. CONCLUSÕES A classificação de risco para transmissão de doenças imunopreveníveis é um mecanismo importante para auxiliar os gestores na definição de prioridades. O projeto estadual de pesquisa-ação empregou um método que possibilitou a construção e a execução de planos de ação singulares a cada município, direcionando a melhoria dos indicadores de imunização no estado.

ABSTRACT OBJECTIVE Analyze the impact of the state research-action project on immunization indicators (vaccination coverage – VC, homogeneity of vaccination coverage – HVC, dropout rate – DR, and risk rating) before and after the intervention in municipalities and priority Regional Health Administrations/Regional Health Superintendencies (RHA/RHS). METHODS The state research-action project was a before-after community clinical trial conducted in 212 municipalities belonging to eight RHA/RHS in the state of Minas Gerais, Brazil. The study sample comprised RHA/RHS with a decreasing trend for routine vaccination coverage in children under one year from 2015 to 2020. This study used secondary VC and DR data from 10 immunobiologicals recommended for children younger than two years from January to December 2021 (pre-intervention period, prior to the state research-action project) and from January to December 2022 (post-intervention period). The categorical variables were presented in proportions, and initially, a comparison was made between those of DR, HVC, and the risk rating for the transmission of vaccine-preventable diseases, according to the two periods (2021 and 2022), using the McNemar test. RESULTS All immunization indicators increased after conducting the research-action project. In 2021, 80.66% of the state’s municipalities had a risk rating for the transmission of vaccine-preventable diseases as “high and very high.” In 2022, the value reduced to 68.40%. CONCLUSIONS Risk rating for the transmission of vaccine-preventable diseases is an important mechanism to assist managers in defining priorities. The state research-action project used a method that enabled the construction and execution of unique action plans for each municipality, directing the improvement of immunization indicators in the state.

https://doi.org/10.11606/s1518-8787.2024058005484

Leishmania (Sauroleishmania) tarentolae versus pathogenic species: comparative evaluation of protease activity, glycoconjugates, resistance to complement and metabolome composition Sauroleishmania (Sauroleishmania species activity glycoconjugates
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Andrade, Filipe Fideles Duarte

; Vitório, Jéssica Gardone

; Canuto, Gisele André Baptista

; Nunes, Fernanda Freire Campos

; Rodrigues, Isabela Aurora

; Almeida, Ana Paula Martins Morais

; Nascimento, Frederico Crepaldi

; Costa, Adriana Oliveira

; Vieira, Tamara da Silva

; Silva, Ana Carolina Carvalho

; André, Leiliane Coelho

; Gontijo, Célia Maria Ferreira

; Junqueira, Caroline

; Toledo, Juliano Simões de

; Fernandes, Ana Paula

; Soares, Rodrigo Pedro

Memórias do Instituto Oswaldo Cruz

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2024, Volume 119 elocation e230243

Abstract: En | Text: En | PDF: En

BACKGROUND Leishmania tarentolae is a non-pathogenic species found in lizards representing an important model for Leishmania biology. However, several aspects of this Sauroleishmania remain unknown to explain its low level of virulence. OBJECTIVES We reported several aspects of L. tarentolae biology including glycoconjugates, proteolytic activities and metabolome composition in comparison to pathogenic species (Leishmania amazonensis, Leishmania braziliensis, Leishmania infantum and Leishmania major). METHODS Parasites were cultured for extraction and purification of lipophosphoglycan (LPG), immunofluorescence probing with anti-gp63 and resistance against complement. Parasite extracts were also tested for proteases activity and metabolome composition. FINDINGS Leishmania tarentolae does not express LPG on its surface. It expresses gp63 at lower levels compared to pathogenic species and, is highly sensitive to complement-mediated lysis. This species also lacks intracellular/extracellular activities of proteolytic enzymes. It has metabolic differences with pathogenic species, exhibiting a lower abundance of metabolites including ABC transporters, biosynthesis of unsaturated fatty acids and steroids, TCA cycle, glycine/serine/threonine metabolism, glyoxylate/dicarboxylate metabolism and pentose-phosphate pathways. MAIN CONCLUSIONS The non-pathogenic phenotype of L. tarentolae is associated with alterations in several biochemical and molecular features. This reinforces the need of comparative studies between pathogenic and non-pathogenic species to elucidate the molecular mechanisms of virulence during host-parasite interactions. nonpathogenic non However L glycoconjugates amazonensis braziliensis major. major . major) LPG, , (LPG) antigp63 antigp anti gp anti-gp6 complement surface gp6 complementmediated mediated lysis intracellularextracellular intracellular extracellular enzymes transporters steroids cycle glycineserinethreonine glycine serine threonine glyoxylatedicarboxylate glyoxylate dicarboxylate pentosephosphate pentose phosphate pathways features hostparasite host parasite interactions (LPG antigp6 anti-gp

https://doi.org/10.1590/0074-02760230243

Impact of a research-action on vaccination indicators in the state of Minas Gerais, Brazil researchaction research action Gerais
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Souza, Janaina Fonseca Almeida

; Silva, Thales Philipe Rodrigues da

; Oliveira, Thais Moreira

; Vimieiro, Aline Mendes

; Teixeira, Antônia Maria da Silva

; Soares, Adriana Coelho

; Ribeiro, Elice Eliane Nobre

; Freitas, Giselle Lima de

; Gaspar, Eduarda Dantas

; Matozinhos, Fernanda Penido

Revista de Saúde Pública

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2024, Volume 58 elocation 09

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.11606/s1518-8787.2024058005484

MACRONUTRIENTS OF MOTHERS’ MILK OF VERY LOW BIRTH WEIGHT INFANTS: ANALYSIS ACCORDING TO GESTATIONAL AGE AND MATERNAL VARIABLES
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Moreira, Maria Elisabeth Lopes

; Lucena, Sabrina Lopes

; Magalhães, Patrícia Sffeir Coelho de

; Rocha, Adriana Duarte

; Costa, Ana Carolina Carioca

; Soares, Fernanda Valente Mendes

Revista Paulista de Pediatria

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2021, Volume 39 elocation e2019097

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Analisar a composição dos macronutrientes presentes no leite de mães de recém-nascidos pré-termo (RNPT) - gorduras, carboidratos e calorias - por idade gestacional (IG), idade cronológica (IC) e variáveis maternos. Métodos: Estudo longitudinal para analisar 215 amostras de leite de 51 mães de RNPT admitidos em três unidades neonatais do Rio de Janeiro de maio/2013 a janeiro/2014. A coleta de leite foi realizada por bomba coletora, em dia fixo a cada semana até a alta. Utilizou-se a técnica espectrofotométrica com análise de infravermelho (MilkoScan Minor 104) para a análise quantitativa. Uma amostra de 7 mL de leite humano foi retirada do volume total de leite extraído pela mãe. Os dados foram agrupados por IG (25-27, 28-31, 32-36 e 37-40 semanas) e por IC (0-4, 5-8, 9-12 e 13-16 semanas). Resultados: Proteínas, carboidratos, gorduras e calorias não apresentaram nenhum padrão de mudança, não havendo diferença entre os grupos de IG. Quando os macronutrientes foram analisados por grupos de IC, a proteína diminuiu, com diferença significante entre os dois primeiros grupos de IC. Carboidratos, gorduras e calorias apresentaram valores crescentes em todos os grupos, sem diferença estatística. O ganho de peso durante a gestação, a presença de hipertensão arterial e a idade materna foram associados a alterações de gordura e calorias no primeiro momento da análise do leite. Conclusões: Observou-se redução estatisticamente significante nos níveis de proteína durante as primeiras oito semanas após o nascimento. A IC pode ser um fator importante na composição do leite humano.

ABSTRACT Objective: To analyze the composition of macronutrients present in the milk of mothers of preterm newborn infants (PTNB) - protein, fat, carbohydrate, and calories - by gestational age (GA), chronological age (CA) and maternal variables. Methods: Longitudinal study that analyzed 215 milk samples from the 51 mothers of PTNB admitted in three Neonatal Intensive Care Units of Rio de Janeiro from May/2013-January/2014. Milk collection was performed by pickup pump, on a fixed day of each week until discharge. The spectrophotometric technique with Infrared Analysis (MilkoScan Minor 104) was used for the quantitative analysis. A sample of 7 mL of human milk was taken from the total volume of milk extracted by the mother. The data was grouped by GA (25-27, 28-31, 32-36, 37-40 weeks) and by CA (zero to 4, 5-8, 9-12, 13-16 weeks). Results: Protein, carbohydrate, fat and calories did not show any pattern of change, with no difference among groups of GA. When the macronutrients were analyzed by groups of CA, protein decreased, with significant difference between the first two groups of CA. Carbohydrates, fat and calories presented increasing values in all groups, without significant differences. Weight gain during pregnancy, maternal hypertension and maternal age were associated with changes in fat and calories in the first moment of the analysis of milk. Conclusions: There was a significant decrease in the levels of protein during the first eight weeks after birth. CA may be an important factor in the composition of human milk.

https://doi.org/10.1590/1984-0462/2021/39/2019097 2588 downloads

Interobserver analysis of safety practices and behaviors adopted by elderly people to prevent falls
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Baixinho, Cristina Rosa Soares Lavareda

; Dixe, Maria dos Anjos Coelho Rodrigues

; Madeira, Carla

; Alves, Silvia

; Henriques, Maria Adriana

Revista Latino-Americana de Enfermagem

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2020, Volume 28 elocation e3268

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Objective: determine the psychometric properties of the safety practices and behaviors dimension of the Scale of Practices and Behaviors of Institutionalized Elderly People to Prevent Falls in a sample of elderly people with cognitive decline. Method: methodological study, with a quantitative approach, to assess the psychometric properties of the mentioned scale in a sample with 102 elderly people with cognitive decline who lived in two long-term care institutions for the public in this age group. Internal consistency evaluation was carried out by calculating the Cronbach’s alpha coefficient; interobserver reliability was expressed by Cohen’s kappa coefficient; and temporal stability, by obtaining Spearman correlation. Compliance with all ethical procedures was observed. Results: the dimension of safety practices and behaviors showed α = 0.895 for its 11 items. Seven out of the 11 items reached good to excellent agreement among the experts for interobserver reliability. Kappa index values indicated that the instrument is valid and reliable. Safety practices and behaviors were influenced by institutionalization time, being at least 85 years old, and gait skills. Conclusion: the results pointed out that the instrument has good reproducibility and is valid and reliable, which allows its use in clinical practice in elderly people with cognitive decline as well as in research.

Objetivo: determinar las propiedades psicométricas de la dimensión de prácticas y conductas de seguridad de la Escala de prácticas y comportamientos de los ancianos institucionalizados para prevenir las caídas, sobre una muestra de ancianos con deterioro cognitivo. Método: estudio metodológico de abordaje cuantitativo para evaluar las propiedades psicométricas de la escala sobre muestra de 102 ancianos con deterioro cognitivo, residentes en dos hogares para ancianos. Evaluación de consistencia interna verificada por α de Cronbach, confiabilidad interobservadores calculada por coeficiente de concordancia Kappa de Cohen, estabilidad temporal comprobada por correlación de Spearman. Fueron contemplados todos los procedimientos éticos. Resultados: la dimensión de prácticas y comportamientos de seguridad de la escala expresa α=0,895 para sus 11 ítems. En confiabilidad interobservadores, 7 de los 11 ítems obtienen buena o excelente concordancia entre los evaluadores. Los valores del índice Kappa evidencian que el instrumento es válido y fidedigno. Las prácticas de comportamiento de seguridad están influidas por el tiempo de institucionalización, edad superior a 85 años y capacidad de marcha. Conclusión: los resultados demuestran buena reproductividad, el instrumento es válido y confiable, pudiéndoselo utilizar en la clínica con ancianos con deterioro cognitivo y en la investigación.

Objetivo: determinar as propriedades psicométricas da dimensão das práticas e dos comportamentos de segurança da Escala de Práticas e Comportamentos dos Idosos Institucionalizados para Prevenir Quedas numa amostra de idosos com declínio cognitivo. Método: estudo metodológico, com abordagem quantitativa, para a avaliação das propriedades psicométricas da escala numa amostra de 102 idosos com declínio cognitivo, residentes em duas Instituições de Longa Permanência para Idosos. A avaliação da consistência interna foi efetuada pelo α de Cronbach, a confiabilidade interobservadores, calculada pelo coeficiente de concordância Kappa de Cohen e a estabilidade temporal, pela correlação de Spearman. Todos os procedimentos éticos foram contemplados no estudo. Resultados: a dimensão das práticas e dos comportamentos de segurança da escala apresentou um α=0,895 para os seus 11 itens. Na confiabilidade interobservador, 7 dos 11 itens obtiveram de boa a excelente concordância entre os juízes. Os valores do Índice Kappa evidenciam que o instrumento é válido e fidedigno. As práticas e os comportamentos de segurança são influenciados pelo tempo de institucionalização, idade superior a 85 anos e capacidade de marcha. Conclusão: os resultados indicam uma boa reprodutibilidade, o instrumento é válido e fidedigno, permitindo a utilização do instrumento na clínica em idosos com declínio cognitivo e na investigação.

https://doi.org/10.1590/1518-8345.3209.3268 53 downloads

Interobserver analysis of safety practices and behaviors adopted by elderly people to prevent falls
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Baixinho, Cristina Rosa Soares Lavareda

; Dixe, Maria dos Anjos Coelho Rodrigues

; Madeira, Carla

; Alves, Silvia

; Henriques, Maria Adriana

Revista Latino-Americana de Enfermagem

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2020, Volume 28 elocation e3268

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/1518-8345.3209.3268 1602 downloads

Falls in long-term care institutions for elderly people: protocol validation
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Baixinho, Cristina Rosa Soares Lavareda

; Dixe, Maria dos Anjos Coelho Rodrigues

; Henriques, Maria Adriana Pereira

Revista Brasileira de Enfermagem

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aug 2017, Volume 70 N. 4 Pages 740 - 746

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivos: Validar o conteúdo de um protocolo para a gestão do risco de queda em Instituições de Longa Permanência para Idosos. Método: Estudo metodológico, de abordagem quantiqualitativa, utilizando a técnica de Delphi. O instrumento, construído com base na literatura, foi enviado por via electrónica, para obter consenso entre os 14 peritos que respeitam os critérios de inclusão definidos. Resultados: Os 27 indicadores do protocolo estão organizados em três dimensões: Preparar a Institucionalização (IRA=,88); Gerir o Risco de Queda ao longo da Institucionalização (IRA=,9) e Liderar a comunicação e formação (IRA=1), com um CVI=,91. Foram efetuadas duas rodadas para se obter consenso superior a 80% em todos os itens. Conclusão: Os valores obtidos no teste de fidedignidade (>0,8) atestam que o protocolo pode ser utilizado para atingir o fim que se pretende. A próxima etapa é a validação clínica do protocolo com idosos residentes em Instituições de Longa Permanência para Idosos.

ABSTRACT Objectives: To validate the content of a fall management risk protocol in long-term institutions for elderly people. Methods: Methodological, quanti-qualitative study using the Delphi technique. The tool, based on the literature, was sent electronically to obtain consensus among the 14 experts that meet the defined inclusion criteria. Results: The 27 indicators of the protocol are organized in three dimensions: prepare for the institutionalization (IRA=.88); manage the risk of falls throughout the institutionalization (IRA=.9); and lead the communication and formation (IRA=1), with a CVI=.91. Two rounds were performed to get a consensus superior to 80% in every item. Conclusion: The values obtained in the reliability test (>0.8) show that the protocol can be used to meet the intended goal. The next step is the clinic validation of the protocol with residents of long-term care institutions for elderly people.

RESUMEN Objetivos: Validar el contenido de un protocolo para gestión de riesgo de caídas en Residencias Geriátricas. Método: Estudio metodológico, de abordaje cualicuantitativo, utilizando técnica de Delphi. El instrumento elaborado con base en la literatura fue enviado por vía electrónica para obtener consenso entre los 14 peritos que observan los criterios de inclusión definidos. Resultados: Los 27 indicadores del protocolo están organizados en tres dimensiones: Preparar la Institucionalización (IRA=,88); Gerenciar el Riesgo de Caída durante la institucionalización (IRA=,9); y Liderar la comunicación y formación (IRA=1), con un CVI=,91. Fueron efectuadas dos rondas para obtener consenso superior al 80% en todos los ítems. Conclusión: Los valores obtenidos en el test de fidelidad (>0,8) certifican que el protocolo puede utilizarse para alcanzar el fin pretendido. La siguiente etapa será la validación clínica del protocolo con ancianos que moren en Residencias Geriátricas.

https://doi.org/10.1590/0034-7167-2017-0109 5102 downloads

Falls in long-term care institutions for elderly people: protocol validation
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Baixinho, Cristina Rosa Soares Lavareda

; Dixe, Maria dos Anjos Coelho Rodrigues

; Henriques, Maria Adriana Pereira

Revista Brasileira de Enfermagem

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aug 2017, Volume 70 N. 4 Pages 740 - 746

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

https://doi.org/10.1590/0034-7167-2017-0109 32 downloads

Clinical outcomes of medication therapy management services in primary health care
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Mendonça, Simone de Araújo Medina

; Melo, Angelita Cristine

; Pereira, Gabriela Cristina Coelho

; Santos, Danielle Maria de Souza Serio dos

; Grossi, Elisa Brandão

; Sousa, Maria do Carmo Vilas Boas

; Oliveira, Djenane Ramalho de

; Soares, Adriana Cristina

Brazilian Journal of Pharmaceutical Sciences

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sep 2016, Volume 52 N. 3 Pages 365 - 373

Abstract: En | Text: En | PDF: En

ABSTRACT This study evaluates whether the integration of pharmacists into health-care teams through the delivery of pharmaceutical care-based medication therapy management (MTM) services can improve the clinical outcomes of patients with chronic health conditions in the primary health-care setting. A retrospective descriptive study of 92 outpatients assisted by MTM pharmacists in primary health-care units was carried out over 28 months (median follow-up: 05 months). Patients were followed up by MTM pharmacists, with a total of 359 encounters and a ratio of 3.9 encounters per patient. The prevalence of hypertension, diabetes mellitus and dyslipidaemia was 29.5%, 22.0% and 19.4%, respectively. There was a high prevalence of drug-related problems with a ratio of 3.4 per patient. Pharmacists performed a total of 307 interventions to prevent or resolve drug-related problems. With regard to control of the most prevalent chronic medical conditions, a high percentage of patients reached their therapy goals by the last encounter with the pharmacist: 90.0% for hypertension, 72.3% for diabetes mellitus and 90.3% for dyslipidaemia. MTM services provided by pharmacists resolved drug therapy problems and improved patients' clinical outcomes. This study provides evidence for health-care managers of the need to expand the clinical role of pharmacists within the Brazilian public health-care system.

https://doi.org/10.1590/s1984-82502016000300002 4204 downloads

10.

Porokeratosis ptychotropica: a rare manifestation with typical histological exam
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Veasey, John Verrinder

; Dalapicola, Monique Coelho

; Lellis, Rute Facchini

; Campaner, Adriana Bittencourt

; Manzione, Thiago da Silveira

; Rodrigues, Maria Clarissa de Faria Soares

Anais Brasileiros de Dermatologia

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aug 2016, Volume 91 N. 4 Pages 496 - 498

Abstract: En | Text: En | PDF: En

Abstract: Porokeratosis is a disorder of epidermal keratinization characterized clinically by a distinctive ridge-like border, and histologically by cornoid lamellae. The known clinical variants of porokeratosis are: classic porokeratosis of Mibelli, disseminated superficial (actinic) porokeratosis (DSAP), porokeratosis palmaris et plantaris disseminata, linear porokeratosis and punctate porokeratosis. In 1995, a seventh form was described as porokeratosis ptychotropica: a verrucous form resembling psoriasis involving the gluteal cleft presenting on the histological exam multiple cornoid lamellae. There are very few reports in the literature of this clinical variant. The present study describes the case of a healthy male presenting gluteal hyperkeratotic plaques for 22 years. He had been to several dermatologists, none of them had achieved a definitive diagnosis. We present a typical clinical presentation and its dermoscopy findings, in addition to histological examination that confirmed the diagnosis.

https://doi.org/10.1590/abd1806-4841.20164397 1756 downloads

11.

Leptospira spp. em bovinos leiteiros do estado do Maranhão, Brasil: frequência, fatores de risco e mapeamento de rebanhos reagentes
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Paixão, Adriana Prazeres

; Santos, Hamilton Perreira

; Alves, Lúcia Maria Coêlho

; Pereira, Helder de Moraes

; Carvalho, Robert Ferreira Barroso de

; Costa Filho, Valter Marchão

; Oliveira, Emerson Antônio Araújo de

; Soares, Diego Moraes

; Beserra, Priscila Alencar

Arquivos do Instituto Biológico

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2016, Volume 83 elocation e1022014

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: O presente estudo teve como objetivo determinar a frequência, os fatores de risco e o mapeamento de focos em rebanhos leiteiros do estado do Maranhão, Brasil, associados à Leptospira spp. Foram colhidas 420 amostras de soros sanguíneos de fêmeas com idade ≥24 meses selecionadas de forma aleatória simples, distribuídas em 70 rebanhos provenientes de 14 municípios. Foi aplicado um questionário epidemiológico para investigar os principais fatores de riscos associados à infecção. As amostras foram submetidas à prova de soroaglutinação microscópica (SAM), sendo utilizados 24 sorovares de Leptospira spp. Das amostras analisadas, 70 (100%) para rebanhos e 420 (100%) para animais foram reagentes a pelo menos um dos sorovares de Leptospira spp., com títulos variáveis entre 100 e 800. Os sorovares mais prevalentes foram Patoc (410/420; 97%), Castellonis (351/420; 84%), Hardjo (347/420; 83%), Hebdomadis (335/420; 80%), Sentot (328/420; 78%), Wolffi (330/420; 79%), Icterohaemorrhagiae (300/420; 71%) e Pomona (286/420; 69%). As variáveis não realização de inseminação artificial, criação conjunta de caprinos, ovinos, equinos e caninos e maior taxa de nascimento de bezerros no período seco apresentaram associação estatística significativa (p<0,05) à ocorrência de animais sororreagentes para Leptospira interrogans e foram considerados fatores de risco. Os resultados revelaram elevados títulos aglutinantes para diversos sorovares de Leptospira no rebanho bovino leiteiro do estado do Maranhão. Esses resultados demonstram a necessidade de implementação de estratégias que consistem na realização de vacinações, preferencialmente com sorovares regionais, exames sorológicos, aquisição de animais de propriedades idôneas, efetivação de quarentena ao ingresso de novos animais e notificação da doença na Agência de Defesa Agropecuária do Estado.

ABSTRACT: The present study's aim was to determine frequency, risk factors and mapping outbreaks in dairy cattle of Maranhão state, Brazil, associated to Leptospira spp. Four hundred and twenty samples of blood serum from females were analyzed, age ≥24 months, selected in a random way, distributed in 70 herds from 14 townships. An epidemiological questionnaire was applied to investigate possible factors that could have been associated to the infection. Serum samples were submitted to the serum agglutination test (SAT). It was used 24 serovars from the Leptospira spp. complex. From the analyzed samples, 70 (100%) for herds and 420 (100%) for animals were reagent to at least one of the Leptospira spp. serovar, reaching titles between 100 and 800. The most prevalent serovars were Patoc (410/420; 97%), Castellonis (351/420; 84%), Hardjo (347/420; 83%), Hebdomadis (335/420; 80%), Sentot (328/420; 78%), Wolffi (330/420; 79%), Icterohaemorrhagiae (300/420; 71%) and Pomona (286/420; 69%). From the variables considered as risk factors, the not utilization of artificial insemination, mixed herds of goats, sheeps, equines and canines in the properties, and the birth of calves in the non-rainy period showed significant statistical association (p<0.05) to the risk of infection with Leptospira interrogans . The results show elevated levels of leptospirosis frequency in dairy cattle herd from Maranhão state. Therefore, there is a necessity to implement strategies consisting of vaccinations with region serovares and serological exams, establishment of quarantine for arrival of new animals, monitoring existent herds in the properties and notification of the disease to the State Animal Health Agency.

https://doi.org/10.1590/1808-1657001022014 3593 downloads

12.

I Diretriz brasileira de cardio-oncologia pediátrica da Sociedade Brasileira de Cardiologia
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Seber, Adriana

; Miachon, Adriana Siviero

; Tanaka, Ana Cristina Sayuri

; Castro, Ângela Maria Spínola e

; Carvalho, Antônio Carlos

; Petrilli, Antônio Sergio

; Macedo, Carla Renata Donato Pacheco

; Nars, Clarissa Carvalho Fongaro

; Terzian, Claudia Naufel

; Castro Junior, Claudio Galvão de

; Santos, Cleusa Cavalcanti Lapa

; Guerra, Cristina Chaves dos Santos

; Silva, Dafne Cardoso Bourguignon da

; Bassi, Débora Ugayama

; Azeka, Estela

; Feitosa, Fabiana Aragão

; Hamamoto, Fernando

; Szarf, Gilberto

; Lederman, Henrique Manoel

; Rigon Junior, Humberto João

; Jatene, Ieda Biscegli

; Mota, Isabele Coelho Fonseca da

; Perrud, Jeferson Adriano

; Soares Junior, José

; Gutierrez, Julián Arango

; Perin, Juliana Pepe Marinho

; Soares, Juliana dos Santos

; Catani, Liane Hulle

; Tsai, Liliana Yu

; Vianna, Livia Cristina

; Paiva, Marcelo Goulart

; Santos, Marcelo José

; Ishigai, Marcia Marcelino de Souza

; Diógenes, Maria Suely Bezerra

; Alves, Maria Teresa de Seixas

; Piedade, Maria Tereza Castro

; Parreiras, Mariana

; Cypriano, Mônica

; Negrini, Nilce da Silva

; Campos Filho, Orlando

; Figueiredo, Paula Andrade

; Novaes, Paulo Eduardo

; Camargo, Paulo Roberto

; Maia, Priscila dos Santos

; Petrilli, Renata

; Arduini, Rodrigo Genaro

; Gouveia, Roseane Vasconcelos

; Teruya, Suzana Barbosa Miranda

; Moisés, Valdir Ambrosio

; Morais, Vera Lúcia Lins de

Arquivos Brasileiros de Cardiologia

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may 2013, Volume 100 N. 5 Pages 1 - 68

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.5935/abc.2013S005 17336 downloads

13.

Convivendo com o portador de Alzheimer: perspectivas do familiar cuidador
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Freitas, Iara Cristina Carvalho

; Paula, Kelvia Coelho Campos de

; Soares, Juliana Lima

; Parente, Adriana da Cunha Menezes

Revista Brasileira de Enfermagem

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aug 2008, Volume 61 N. 4 Pages 508 - 513

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

O presente estudo teve como objetivo descrever e analisar a convivência com o portador de Alzheimer sob a perspectiva do familiar cuidador. Foi utilizada a abordagem qualitativa. A coleta de dados deu-se através de entrevistas semi-estruturadas, a onze familiares cuidadores de portadores da doença de Alzheimer. Para a análise dos dados utilizou-se o referencial de análise de conteúdo, modalidade temática. Nos resultados os depoimentos obtidos foram categorizados como: a convivência com a sintomatologia e a convivência com as limitações. Considerou-se que a doença de Alzheimer é uma doença familiar e para tanto necessita de uma abordagem singular do enfermeiro que deve assumir seu papel de educador, pesquisador e envolver-se diretamente na assistência prestada.

The present study aimed at describing and analyzing the fliving of the patient with Alzheimer's Disease under the perspective of the caregiver relative. It was used a qualitative approach. The data was collected by semi-structured interviews with eleven caregiver relatives of patients with Alzheimer's disease. The data was analyzed by the method of content analysis, thematic modality. In the results, the obtained reports were categorized like: the familiarity with the symptomatology and the familiarity with the limitations. It was considered that the Alzheimer's Disease is a familiar disease and, therefore, it is necessary a singular approach of the nurse who must to assume an educator and researcher role, and must to involve himself directly on the invested assistance.

El presente estudio tuvo como objetivo describir y analizar la convivencia con el portador de Alzheimer bajo la perspectiva del familiar cuidador. Fue usado el abordaje cualitativo, con forma exploratoria y descriptiva. La colecta de datos se dio a través de entrevistas semi-estructuradas, a once familiares cuidadores de portadores de la enfermedad de Alzheimer. Para el análisis de los datos se utilizó el referencial de análisis de contenido, modalidad temática. En los resultados los testimonios obtenidos fueron categorizados como: la convivencia con la sintomatología y la convivencia con las limitaciones. Se consideró que la enfermedad de Alzheimer es una dolencia familiar y para tanto necesita un abordaje singular del enfermero que debe asumir su papel de educador, investigador e involucrarse directamente en la asistencia prestada.

31302 downloads

14.

Convivendo com o portador de Alzheimer: perspectivas do familiar cuidador
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Freitas, Iara Cristina Carvalho

; Paula, Kelvia Coelho Campos de

; Soares, Juliana Lima

; Parente, Adriana da Cunha Menezes

Revista Brasileira de Enfermagem

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aug 2008, Volume 61 N. 4 Pages 508 - 513

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

3 downloads

15.

Schistosomiasis in a low prevalence area: incomplete urbanization increasing risk of infection in Paracambi, RJ, Brazil
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Soares, Marisa S.

; Barreto, Magali G. M.

; Silva, Cesar Luiz P. A. Coelho da

; Pereira, José B.

; Moza, Patrícia G.

; Rey, Luis

; Calçado, Mônica S.

; Lustoza, Adriana

; Maspero, Renato

Memórias do Instituto Oswaldo Cruz

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aug 1995, Volume 90 N. 4 Pages 451 - 458

Abstract: En | Text: En | PDF: En

The risk of schistosomiais infection and heavy infection in the locality of Sabugo was evaluated in relation to housing in areas with different urbanization development and to residential supply with snail-infested water. Critical sanitary conditions were found in areas of incomplete urbanization, where healthy water supply sources were scarce, and draining of sewage, without previous treatment, was made directly to the water-bodies used for domestic and leisure activities, despite being Biomphalaria tenagophila snail breeding-places. Stool examinations (Kato-Katz and Lutz methods) showed prevalence of 2.9%, mean intensity of 79 eggs per gram of stool and 47% of positive cases presenting intense infection. The use of snail-contaminated water for domestic purposes was considered a risk factor for infection. It is concluded that incomplete urbanization would facilitate transmission, probably enhancing the intensity of infection and that a low prevalence could hide a highly focal transmission. The relevance of these facts upon the efficiency of epidemiologic study methods and disease control planning are then discussed.

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