Abstract The expansion of cowpea (Vigna unguiculata (L.) Walp.) crop has created new demands for its breeding programs. Knowledge of its genetic base is fundamental for choosing progenitors when conducting crosses. This study aimed to estimate the genetic base of Brazilian cowpea cultivars released between 1960 and 2022, in addition to identifying the origin of their cytoplasmic genes. Seventy-three cultivars were released in this period; however, only 41 had information about their original crosses. The ancestors CNC0434, Pitiúba and Seridó were used more frequently in crosses. They have also contributed with the highest frequency to the cultivars’ cytoplasmic genes. Therefore, although we found that between 2005 and 2022 there was a 30.95% increase in the contribution of different genotypes, we conclude that the genetic base of cowpea is narrow, and it is necessary to avoid crosses involving CNC0434, Pitiúba and Seridó in future breeding programs of this legume in Brazil. Vigna L. L (L. Walp. Walp 196 genes Seventythree Seventy three period however 4 CNC0434 CNC Therefore 200 202 3095 30 95 30.95 genotypes narrow Brazil (L 19 CNC043 20 309 3 9 30.9 1 CNC04 2 30. CNC0

RESUMO As previsões de afluências em horizonte sub sazonal apresenta potencial para contribuições importantes na gestão de recursos hídricos em operações de barragens hidroelétricas. Estas previsões desafiam as limitações do horizonte de médio-prazo e o estende, preenchendo uma lacuna técnico-cientifica de longa data no ramo das previsões. No Brasil, o uso de previsões hidrológicas em horizonte sub sazonal apresenta potencial para alavancar a produção hidroelétrica do Sistema Interligado Nacional (SIN), uma vez que rotineiramente são empregadas previsões de afluências em reservatórios de até 2 semanas por meio de modelo chuva-vazão. Este estudo objetivou a avaliação estatística de previsões hidrológicas de até 6 semanas utilizando um modelo hidrológico-hidrodinâmico em escala continental associados a previsão de precipitação por conjunto geradas por modelo atmosférico para produzir vazões futuras nas bacias do continente, e consequentemente para as bacias das usinas hidroelétricas do SIN. A avaliação estatística se baseou em métricas determinísticas tipicamente utilizadas pelo agente operador do SIN, e adicionalmente a habilidade das previsões baseadas em modelo atmosférico em relação a previsões baseada na climatológica das vazões observadas nas usinas. A performance das previsões varia de acordo com a estação do ano e localização geográfica, isto é, dependente de regimes hidrológicos distintos. As melhores performances foram obtidas em usinas localizadas nas regiões sudoeste e centro-oeste que possuem sazonalidade bem definida, ao passo que usinas do sul apresentaram maior sensibilidade nas métricas de acordo com a estação do ano. O estudo apresentado servem como contribuição técnico-cientifica para agentes e tomadores de decisão que buscam aprimorar a gestão do recurso hídrico incorporando as previsões estendidas na cadeia operacional. médioprazo médio prazo estende técnicocientifica técnico cientifica Brasil SIN , (SIN) chuvavazão. chuvavazão chuva vazão. vazão chuva-vazão hidrológicohidrodinâmico hidrológico hidrodinâmico continente geográfica é distintos centrooeste centro oeste definida operacional (SIN

ABSTRACT Inflow prediction on sub-seasonal timescale have the potential for important contributions to the management of water resources in hydroelectric dam operations. These forecasts challenge the limitations of the medium-term and extend it, bridging a long-standing technical-scientific gap in the forecasting field. In Brazil, the use of sub-seasonal hydrological predictions can boost the hydroelectric production of the National Interconnected System (SIN), since inflow forecast in reservoirs of up to 2 weeks are routinely used using a rain-flow model. This study aimed at the statistical evaluation of hydrological forecasts of up to 6 weeks using a hydrological-hydrodynamic model on a continental scale associated with ensemble precipitation forecasts generated by an atmospheric model, producing future streamflow in the continent basins, and consequently at the SIN’s hydroelectric dams. The statistical evaluation was based on deterministic scores typically used by the SIN operating agent, and additionally we assessed the skill of forecasts based on atmospheric models in relation to simpler forecasts based on the climatology of observed inflows. The performance of the forecasts varies according to the season and geographic location, that is, depending on different hydrological regimes. The best performances were obtained in dams located in the southwest and central-west regions, which have well-defined seasonality, while dams in the south showed greater sensitivity in metrics according to the season. The study presented serves as a technical-scientific contribution for agents and decision makers who seek to improve water resource management by incorporating extended forecasts into the operational chain. subseasonal sub seasonal operations mediumterm medium term it longstanding long standing technicalscientific technical scientific field Brazil SIN, , (SIN) rainflow rain flow hydrologicalhydrodynamic hydrodynamic basins SINs s agent inflows location is regimes centralwest central west regions welldefined well defined seasonality chain (SIN

ABSTRACT Sickle Cell Disease (SCD) is a hereditary disease characterized by extravascular and intravascular hemolysis and clinical variability, from mild pain to potentially life-threatening. Arboviruses include mainly Zika (ZIKV), Chikungunya (CHKV), and Dengue (DENV) virus, and are considered a public and social health problem. The present cross-sectional observational study aimed to investigate the prevalence of arbovirus infection in SCD patients from two Brazilian cities, Salvador and Manaus located in Bahia and Amazonas states respectively. A total of409 individuals with SCD were included in the study, and 307 (75.06 %) patients tested positive for DENV-IgG, 161 (39.36 %) for ZIKV-IgG, and 60 (14.67 %) for CHIKV-IgG. Only one individual was positive for DENV-NS1 and another for DENV-IgM, both from Salvador. No individuals had positive serology for ZIKV-IgM or CHIKV-IgM. Arbovirus positivity by IgG testing revealed that the SCD group presented high frequencies in both cities. Interestingly, these differences were only statistically significant for ZIKV-IgG (p = 0.023) and CHIKV-IgG (p = 0.005) among SCD patients from Manaus. The reshaping of arbovirus from its natural habitat by humans due to disorderly urban expansion and the ease of international Mobility has been responsible for facilitating the spread of vector-borne infectious diseases in humans. We found the need for further studies on arboviruses in this population to elucidate the real association and impact, especially in acute infection. We hope that this study will contribute to improvements in the personalized clinical follow-up of SCD patients, identifying the influence of arbovirus infection in severe disease manifestations. (SCD variability lifethreatening. lifethreatening life threatening. threatening life-threatening ZIKV, ZIKV , (ZIKV) CHKV, CHKV (CHKV) DENV (DENV virus problem crosssectional cross sectional cities respectively of40 30 75.06 7506 75 06 (75.0 % DENVIgG, DENVIgG IgG, DENV-IgG 16 39.36 3936 39 36 (39.3 ZIKVIgG, ZIKVIgG 6 14.67 1467 14 67 (14.6 CHIKVIgG. CHIKVIgG CHIKV IgG. DENVNS1 DENVNS NS1 NS DENV-NS DENVIgM, DENVIgM IgM, IgM DENV-IgM ZIKVIgM CHIKVIgM. CHIKVIgM IgM. CHIKV-IgM Interestingly p 0.023 0023 0 023 0.005 0005 005 vectorborne vector borne impact followup follow up manifestations (ZIKV (CHKV of4 3 75.0 750 7 (75. 1 39.3 393 (39. 14.6 146 (14. 0.02 002 02 0.00 000 00 75. (75 39. (39 14. (14 0.0 (7 (3 (1 0. (

ABSTRACT Objective Glucagon-like peptide-1 (GLP1) and leptin (Lep) are afferent signals that regulate energy metabolism. Lactational hypernutrition results in hyperphagia and adiposity in adult life, and these events can be prevented by exercise. We evaluated the effects of swimming training on hypothalamic (GLP1-R) and Lep receptor (Lep-R) gene expressions in lactational hypernutrition-induced obesity. Methods On the 3rd postnatal day, the litter sizes of lactating dams were adjusted to small litters (SL; 3 pups/dams) or normal litters (NL; 9 pups/dams). After weaning (21 days), NL and SL male rats were randomly distributed to sedentary (Sed) and exercised (Exe) groups. Exercised mice swam (30 min/3 times/week) for 68 days. Food intake and body weight gain were registered. At 92 days, intraperitoneal glucose and insulin tolerance tests were performed and rats were euthanized at 93 days; adipose tissue depots were weighed, and blood counts and plasma biochemical analyses performed. Hypothalamus were isolated to evaluate Lep-R and GLP1-R gene expressions. Results Small litters sedentary rats presented increased body weight gain, adiposity, insulin sensibility and higher fasting values of glucose and triglycerides, besides higher hypothalamic gene expressions of Lep-R and GLP1-R, compared to NLSed animals. SLExe rats did not develop obesity or metabolic abnormalities and Lep-R and GLP1-R hypothalamic gene expressions were normalized. Conclusion Lactational hypernutrition induces obesity and metabolic dysfunction in adult life, in association with higher hypothalamic expressions of the Lep-R and GLP1-R genes. Exercise prevented obesity and improved metabolic state in SL overnourished rats, and normalized their hypothalamic Lep-R and GLP1-R gene expressions. Glucagonlike Glucagon like peptide1 peptide 1 peptide- GLP1 GLP (GLP1 (Lep metabolism life exercise GLP1R GLPR R (GLP1-R LepR (Lep-R hypernutritioninduced induced rd day (SL pups/dams pupsdams pups (NL pups/dams. . 21 (2 days , days) Sed (Sed Exe (Exe groups 30 (3 min3 min min/ times/week timesweek times week 6 registered weighed triglycerides GLP1R, R, animals genes (GLP 2 (

ABSTRACT Purpose: This study aimed to evaluate the effects of ozone therapy applied topically and/or by bagging on the healing of clean wounds induced in rat’s skin. Methods: One hundred and twenty male rats of about 16 weeks old was divided into five groups: G1) saline solution (0.9%); G2) sunflower oil; G3) ozonated sunflower oil; G4) ozone bagging; G5) association of ozonated sunflower oil and ozone bagging. The wounds were evaluated through macroscopic, morphometric, histopathologic, and tensile strength analyses. Results: Analysis among groups showed a lower percentage of wound contraction in G1 compared to G4 only in M7D. The tensile strength of the wounds showed differences among groups in the seventh (M7D) and the 14th (M14D) postoperative day, and among time points in G1 (M14D > M7D). The elongation of the wounds showed differences in G3 (M7D > M14D). Histological evaluation of the wounds showed significant change in bleeding, mixed to mononuclear infiltrate, congestion, and tissue disorganization for tissue organization between groups and time points. Conclusions: Ozone therapy applied topically and/or by bagging was not deleterious to the healing of clean wounds induced in rat’s skin, but ozone bagging showed the best contribution to the healing process. Purpose andor or rat s skin Methods 1 G 0.9% 09 0 9 (0.9%) G2 G5 macroscopic morphometric histopathologic analyses Results M7D MD M D th M14D day . M7D) M14D. M14D) bleeding infiltrate congestion Conclusions process 0.9 (0.9% 0. (0.9 (0. (0 (

Resumo As secas podem acarretar crise hídrica, que pode afetar a produção de alimento e causar impactos socioambientais. Esta pesquisa objetiva analisar o comportamento das secas meteorológica e hidrológica por meio do emprego de índices de seca padronizados, calculados a partir de projeções climáticas dos cenários RCP4.5 e RCP8.5. Foram utilizados os índices SPI e SPEI para secas meteorológica e o SSFI para secas hidrológica, a partir de vazões simuladas pelos modelos hidrológicos SWAT e VIC. Para o clima presente (1961a 2005) os índices SPEI e SPI apresentaram resultados semelhantes com relação a eventos extremos de seca. Para o clima futuro (2005 a 2099) o SPI apresentou resultados semelhantes de seca quando considerado os cenários RCP4.5 e RCP8.5. O SPEI apresentou resultados mais divergentes quando considerado cada cenário. No clima futuro o SSFI simulou secas extremas para os cenários, RCP4.5 e RCP8.5. Levando em consideração o comportamento dos índices de seca para uma mesma escala de tempo, a seca meteorológica pode ter influenciado a seca hidrológica, gerando redução das vazões do rio quase simultaneamente devido à pequena área da bacia considerada. Estes resultados podem ser utilizados no planejamento de políticas e estratégias que visem minimizar os impactos das secas na região. hídrica socioambientais padronizados RCP45 RCP RCP4 5 RCP4. RCP85 RCP8 RCP8.5 VIC 1961a 2005 (200 2099 cenário tempo considerada região RCP8. 200 (20 209 20 (2 2 (

Abstract Droughts can lead to a water crisis, which can affect food production and cause socio-environmental impacts. This research aims to analyze the behavior of meteorological and hydrological droughts through the use of standardized drought indices, calculated from climate projections of the RCP4.5 and RCP8.5 scenarios. The SPI and SPEI indices were used for meteorological droughts and the SSFI for hydrological droughts, based on discharge simulated by the SWAT and VIC hydrological models. For the current climate (1961 to 2005) the SPEI and SPI indices showed similar results regarding extreme drought events. For the future climate (2005 to 2099), the SPI presented similar drought results when considering the RCP4.5 and RCP8.5 scenarios. The SPEI presented more divergent results when considering each scenario. In the future climate, the SSFI simulated extreme droughts for the scenarios, RCP4.5 and RCP8.5. Taking into account the behavior of drought indices for the same time scale, meteorological drought may have influenced hydrological drought, generating a reduction in river discharges almost simultaneously due to the small area of the basin considered. These results can be used in planning policies and strategies that aim to minimize the impacts of droughts in the region. crisis socioenvironmental socio environmental RCP45 RCP RCP4 5 RCP4. RCP85 RCP8 RCP8. scenarios models 1961 (196 2005 events (200 2099, 2099 , 2099) scenario scale considered region 196 (19 200 (20 209 19 (1 20 (2 1 ( 2

RESUMO Espécies nativas plantadas em locais anteriormente ocupados por pastagem degradada podem desempenhar um papel importante no suprimento de biomassa e no sequestro de carbono atmosférico. Avaliar o desempenho das espécies nativas em diferentes espaçamentos de plantio se torna importante para a silvicultura e o manejo de novas espécies com potencial econômico. Schizolobium parahyba var. amazonicum é uma espécie não tradicional na região sudeste do Brasil, e foi estabelecida em área de pastagem com objetivo de avaliar o crescimento, a biomassa e o estoque de carbono. Foram testados cinco espaçamentos de plantio em monocultivo (3 m x 2 m, 3 m x 3 m, 4 m x 3 m, 4 m x 4 m e 5 m x 5 m) com 9 parcelas experimentais. A biomassa da parte aérea e radicular, bem como o teor de carbono foram obtidos por meio do método direto. A biomassa variou 31.4 and 52.9 kg árvore-1 nos espaçamentos 3 m x 2 m e 5 m x 5 m, repectivamente. O maior estoque de carbono foi observado no espaçamento mais adensado (19.43 Mg ha-1), sendo 50% maior do que no espaçamento menos adensado. O espaçamento não influenciou a biomassa e o estoque de carbono nas raízes por unidade de área. O desempenho da espécie deveria ser monitorado em idades avançadas dado as diferentes respostas ao espaçamento de plantio e competição entre plantas. atmosférico econômico var Brasil crescimento ( experimentais radicular direto 314 31 31. 529 52 52. árvore1 árvore 1 árvore- repectivamente 19.43 1943 19 43 (19.4 ha1, ha1 ha , ha-1) 50 plantas 19.4 194 (19. ha-1 19. (19 ha- (1

ABSTRACT Native species planted in areas previously occupied by degraded pasture can play an important role in biomass supply and atmospheric carbon sequestration. Evaluating the performance of native species in different planting spacings becomes important for forestry and the management of new species with economic potential. Schizolobium parahyba var. amazonicum is a non-traditional species in the southeastern region of Brazil and it was established in pasture areas to evaluate growth, biomass, and carbon stock. Five planting spacings (3 m x 2 m, 3 m x 3 m, 4 m x 3 m, 4 m x 4 m, and 5 m x 5 m, in monoculture) were tested in 9 experimental plots. The biomass of the shoot and root, as well as the carbon content, were obtained by the direct method. The biomass varied 31.4 and 52.9 kg tree-1 in the spacing 3 m x 2 m and 5 m x 5 m, respectively. The greater carbon stock was observed in the lower spacing (19.43 Mg ha-1), 50% higher than in the larger spacing. The spacing did not influence the biomass and carbon stock in the roots per unit area. The performance of the species should be monitored at advanced ages given the different responses to planting spacing and competition between plants. sequestration potential var nontraditional non traditional growth ( monoculture plots root content method 314 31 31. 529 52 52. tree1 tree 1 tree- respectively 19.43 1943 19 43 (19.4 ha1, ha1 ha , ha-1) 50 area plants 19.4 194 (19. ha-1 19. (19 ha- (1

Resumo Nas últimas décadas, houve progressos significativos no diagnóstico e no tratamento da distrofia muscular de Duchenne (DMD), considerada a distrofia muscular mais comum na infância. Diretrizes internacionais foram publicadas e revisadas recentemente. Um grupo de especialistas brasileiros desenvolveu um padrão de atendimento baseado em revisão de literatura, com recomendações graduadas pautadas em evidências compiladas em uma publicação dividida em duas partes. A implementação de melhores práticas de manejo ajudou a modificar a história natural desta doença crônica, progressiva, que, no passado, oferecia uma expectativa de vida muito limitada para crianças do sexo masculino. Desde a publicação desse consenso anterior, o diagnóstico, o tratamento com esteroides, a reabilitação e os cuidados sistêmicos ganharam novas possibilidades a partir da divulgação dos resultados de trabalhos originais em algumas dessas áreas. Além disso, as pesquisas e o desenvolvimento de novos fármacos estão em andamento, e algumas intervenções já foram aprovadas para uso em determinados países. Nesse contexto, identificamos a necessidade de rever as recomendações anteriores sobre o manejo dos pacientes brasileiros com DMD. Nosso objetivo principal foi elaborar uma atualização baseada em evidências sobre esses tópicos do consenso. décadas DMD, DMD , (DMD) infância recentemente literatura partes crônica progressiva que passado masculino anterior esteroides áreas disso andamento países contexto (DMD

Abstract In the last few decades, there have been considerable improvements in the diagnosis and care of Duchenne muscular dystrophy (DMD), the most common childhood muscular dystrophy. International guidelines have been published and recently reviewed. A group of Brazilian experts has developed a standard of care based on a literature review with evidence-based graded recommendations in a two-part publication. Implementing best practice management has helped change the natural history of this chronic progressive disorder, in which the life expectancy for children of the male sex in the past used to be very limited. Since the previous publication, diagnosis, steroid treatment, rehabilitation, and systemic care have gained more significant insights with new original work in certain fields. Furthermore, the development of new drugs is ongoing, and some interventions have been approved for use in certain countries. Therefore, we have identified the need to review the previous care recommendations for Brazilian patients with DMD. Our objective was to create an evidence-based document that is an update on our previous consensus on those topics. decades DMD, DMD , (DMD) reviewed evidencebased evidence twopart two part publication disorder limited treatment rehabilitation fields Furthermore ongoing countries Therefore topics (DMD

Abstract Forest fragments are susceptible to environmental shifts and this demands high phenotypic plasticity of the species growing in these areas. In this context, the objective of the present work was to study the phenotypic plasticity of copaíba (Copaifera langsdorffii Desf.) based on morphological and anatomical metrics of the leaflets of plants from six forest fragments. The leaflets of C. langsdorffii individuals of the different fragments did not show qualitative differences, nonetheless, they demonstrated quantitative plasticity. Stomatal density (p = 0.017), specific leaf area (p = 0.009), palisade parenchyma (p = 0.008) and relative water content (p = 0.002), indicated a high luminous, water and nutritional influence on the development of leaflets. Based on the dry mass of the leaflets and the thickness of the palisade parenchyma, the principal component analysis explained 57.43% of the differences found between the variables. The data presented here provides evidence of the phenotypic plasticity of C. langsdorffii which, although occurring in similar soils, showed significant quantitative differences in its morphoanatomical characters. areas context Copaifera Desf. Desf C nonetheless p 0.017, 0017 0.017 , 0 017 0.017) 0.009, 0009 0.009 009 0.009) 0.008 0008 008 0.002, 0002 0.002 002 0.002) luminous 5743 57 43 57.43 variables which soils characters 001 0.01 01 000 0.00 00 574 5 4 57.4 0.0 57. 0.

RESUMO Devido à frequente ocorrência de eventos hidrológicos extremos nos regimes de escoamento dos rios da América do Sul, o presente trabalho tem como objetivo o desenvolvimento de uma plataforma de monitoramento hidrológico aberta ao público, com um acesso amplo e intuitivo, utilizando recursos de um sistema de informação geográfica online, com o intuito de contribuir para um melhor entendimento acerca do comportamento desses desastres naturais. A plataforma de acompanhamento hidrológico dos rios da América do Sul (SARDIM - South America River Discharge Monitor) foi construída com auxílio de recursos de programação em linguagens como Python e Javascript. Os dados da plataforma são provenientes de resultados de um modelo de simulação hidrológica de escala continental (MGB - South America) que utiliza, entre outras informações, dados de precipitação da missão GPM (Global Precipitation Measurement) e do produto MSWEP (Multi-Source Weighted Ensemble Precipitation). Após uma análise estatística das informações resultantes do modelo, a plataforma é atualizada diariamente de forma operacional com novos dados de permanência e tempo de retorno das vazões dos rios, permitindo a identificação, o acompanhamento e a avaliação da intensidade de eventos hidrológicos extremos na América do Sul. público intuitivo online naturais SARDIM Monitor Javascript MGB utiliza Global Measurement MultiSource Multi Source Precipitation. . Precipitation) identificação

ABSTRACT Due to the frequent occurrence of extreme hydrological events in the South American rivers, this work aims to develop a hydrological monitoring platform open to the public, with a wide and intuitive access, using resources of an online geographic information system, in order to contribute to a better understanding of the behavior of these natural disasters. SARDIM (South America River DIscharge Monitor) has been developed using programming resources in languages such as Python and JavaScript. The data of the platform are derived from results of a continental scale hydrological simulation model (MGB - South America) that uses, among other information, precipitation data from the GPM (Global Precipitation Measurement) mission and from the MSWEP (Multi-Source Weighted Ensemble Precipitation) product. After a statistical analysis of the model results, the platform is updated daily and operationally, with new data on the flow duration and the return period of river flows, allowing the identification, monitoring and evaluation of the intensity of extreme hydrological events in South America. rivers public access system disasters Monitor JavaScript MGB uses Global Measurement MultiSource Multi Source product operationally flows identification

Resumen Objetivo Analizar la tendencia de la mortalidad por suicidio en el estado de Espírito Santo y en su Región Serrana en el período de 1996 a 2020. Métodos Estudio descriptivo y analítico de serie temporal con datos consolidados de las muertes por suicidio en la población mayor de 15 años obtenidos del Sistema de Información sobre Mortalidad. Las unidades de análisis fueron el estado de Espírito Santo y su Región Serrana. El análisis de la tendencia se verificó por regresión de Prais-Winsten y por cálculo de la variación porcentual anual. Resultados Se notificaron 3.922 muertes por suicidio en Espírito Santo, de las cuales 525 fueron en la Región Serrana. La tendencia de la mortalidad por suicidio en el estado fue creciente en la población general mayor de 15 años (APC= 5,1; IC95 %= 0,28-9,92; p=0,039). La tendencia de la mortalidad se mantuvo creciente en la población femenina, tanto con relación al estado (APC= 6;5; IC95 %= 1,55-14,46; p=0,012) como en la Región Serrana (APC= 15,2; IC95 %= 1,21-29,20; p=0,035). La mortalidad fue creciente en el grupo de edad de 30 a 59 años en el estado (APC= 3,4; IC95 %= 0,62-6,10; p=0,018) y en la Región Serrana (APC= 2,9; IC95 %= 2,02-3,86; p <0,001). Conclusión La tendencia fue creciente en la población general del estado de Espírito Santo y en su Región Serrana en adultos jóvenes y de sexo femenino. La relevancia de la violencia autoprovocada verificada en los índices analizados en este estudio indica la necesidad de emplear estrategias preventivas, específicamente en mujeres. 199 2020 1 Mortalidad PraisWinsten Prais Winsten anual 3922 3 922 3.92 52 APC= APC (APC 5,1 51 5 IC IC9 % 0,289,92 028992 0,28 9,92 0 28 9 92 0,28-9,92 p=0,039. p0039 p=0,039 . 039 p=0,039) femenina 65 6 6;5 1,5514,46 1551446 1,55 14,46 55 14 46 1,55-14,46 p=0,012 p0012 012 15,2 152 2 1,2129,20 1212920 1,21 29,20 21 29 20 1,21-29,20 p=0,035. p0035 p=0,035 035 p=0,035) 3,4 34 4 0,626,10 062610 0,62 6,10 62 10 0,62-6,10 p=0,018 p0018 018 2,9 2,023,86 202386 2,02 3,86 02 86 2,02-3,86 <0,001. 0001 <0,001 001 <0,001) femenino preventivas mujeres 19 202 392 3.9 5, 289 0,289,9 02899 028 0,2 992 9,9 0,28-9,9 p003 p=0,03 03 6; 5514 1,5514,4 155144 155 1,5 1446 14,4 1,55-14,4 p=0,01 p001 01 15, 2129 1,2129,2 121292 121 1,2 2920 29,2 1,21-29,2 3, 626 0,626,1 06261 062 0,6 610 6,1 0,62-6,1 2, 023 2,023,8 20238 2,0 386 3,8 8 2,02-3,8 000 <0,00 00 39 3. 0,289, 0289 0, 99 9, 0,28-9, p00 p=0,0 551 1,5514, 15514 1, 144 14, 1,55-14, 212 1,2129, 12129 12 292 29, 1,21-29, 0,626, 0626 06 61 6, 0,62-6, 2,023, 2023 38 2,02-3, <0,0 0,289 0,28-9 p0 p=0, 1,5514 1551 1,55-14 1,2129 1212 1,21-29 0,626 0,62-6 2,023 2,02-3 <0, 0,28- p=0 1,551 1,55-1 1,212 1,21-2 0,62- 2,02- <0 p= 1,55- 1,21- <

Resumo Objetivo Analisar a tendência da mortalidade por suicídio no estado do Espírito Santo e em sua Região Serrana no período de 1996 a 2020. Métodos Estudo descritivo e analítico de série temporal com dados consolidados dos óbitos por suicídio na população acima de 15 anos de idade obtidos no Sistema de Informações sobre Mortalidade. As unidades de análise foram o estado do Espírito Santo e sua Região Serrana. A análise da tendência foi verificada pela regressão de Prais-Winsten e pelo cálculo da variação percentual anual. Resultados Foram notificados 3.922 óbitos por suicídio no Espírito Santo e, destes, 525 na Região Serrana. A tendência da mortalidade por suicídio no estado foi crescente na população geral acima de 15 anos (APC= 5,1; IC95%= 0,28-9,92; p=0,039). A tendência da mortalidade se manteve crescente entre a população feminina, tanto em relação ao estado (APC= 6;5; IC95%= 1,55-14,46; p=0,012) como na região serrana (APC= 15,2; IC95%= 1,21-29,20; p=0,035). A mortalidade foi crescente na faixa etária de 30 a 59 anos no estado (APC= 3,4; IC95%= 0,62-6,10; p=0,018) e na Região Serrana (APC= 2,9; IC95%= 2,02-3,86; p <0,001). Conclusão A tendência foi crescente na população geral do estado do Espírito Santo e em sua Região Serrana entre adultos jovens e do sexo feminino. A relevância da violência autoprovocada verificada nas taxas analisadas neste estudo aponta para a necessidade do emprego de estratégias preventivas, especialmente entre as mulheres. 199 2020 1 Mortalidade PraisWinsten Prais Winsten anual 3922 3 922 3.92 destes 52 APC= APC (APC 5,1 51 5 IC95 IC IC95% 0,289,92 028992 0,28 9,92 0 28 9 92 0,28-9,92 p=0,039. p0039 p=0,039 . 039 p=0,039) feminina 65 6 6;5 1,5514,46 1551446 1,55 14,46 55 14 46 1,55-14,46 p=0,012 p0012 012 15,2 152 2 1,2129,20 1212920 1,21 29,20 21 29 20 1,21-29,20 p=0,035. p0035 p=0,035 035 p=0,035) 3,4 34 4 0,626,10 062610 0,62 6,10 62 10 0,62-6,10 p=0,018 p0018 018 2,9 2,023,86 202386 2,02 3,86 02 86 2,02-3,86 <0,001. 0001 <0,001 001 <0,001) feminino preventivas mulheres 19 202 392 3.9 5, IC9 289 0,289,9 02899 028 0,2 992 9,9 0,28-9,9 p003 p=0,03 03 6; 5514 1,5514,4 155144 155 1,5 1446 14,4 1,55-14,4 p=0,01 p001 01 15, 2129 1,2129,2 121292 121 1,2 2920 29,2 1,21-29,2 3, 626 0,626,1 06261 062 0,6 610 6,1 0,62-6,1 2, 023 2,023,8 20238 2,0 386 3,8 8 2,02-3,8 000 <0,00 00 39 3. 0,289, 0289 0, 99 9, 0,28-9, p00 p=0,0 551 1,5514, 15514 1, 144 14, 1,55-14, 212 1,2129, 12129 12 292 29, 1,21-29, 0,626, 0626 06 61 6, 0,62-6, 2,023, 2023 38 2,02-3, <0,0 0,289 0,28-9 p0 p=0, 1,5514 1551 1,55-14 1,2129 1212 1,21-29 0,626 0,62-6 2,023 2,02-3 <0, 0,28- p=0 1,551 1,55-1 1,212 1,21-2 0,62- 2,02- <0 p= 1,55- 1,21- <

Abstract Objective To analyze the trend of suicide mortality in the state of Espirito Santo and its Mountain Region from 1996 to 2020. Methods Descriptive and analytical time series study with consolidated data on deaths by suicide in the population over 15 years old obtained from the Mortality Information System. The units of analysis were the state of Espirito Santo and its Mountain Region. The trend analysis was verified by Prais-Winsten regression and by calculating the annual percentage change. Results A total of 3922 deaths by suicide were reported in Espirito Santo and of these, 525 in the mountain Region. The trend of suicide mortality in the state was increasing in the general population over 15 years old (APC= 5.1; 95%CI= 0.28-9.92; p=0.039). The mortality rate continued to grow among the female population, both in relation to the state (APC= 6.5; 95%CI= 1.55-14.46; p=0.012) and in the mountain region (APC= 15.2; 95%CI= 1.21-29.20; p=0.035). Mortality increased in the age group from 30 to 59 years old in the state (APC= 3.4; 95%CI= 0.62-6.10; p=0.018) and in the Mountain Region (APC= 2.9; 95%CI= 2.02-3.86; p<0.001). Conclusion The suicide trend was growing in the general population of the state of Espirito Santo and its Mountain Region among young and female adults. The relevance of self-inflicted violence verified in the rates analyzed in this study points to the need to use preventive strategies, especially among women. 199 2020 1 System PraisWinsten Prais Winsten change 392 these 52 APC= APC (APC 5.1 51 5 95CI CI 95 95%CI 0.289.92 028992 0.28 9.92 0 28 9 92 0.28-9.92 p=0.039. p0039 p p=0.039 . 039 p=0.039) 6.5 65 6 1.5514.46 1551446 1.55 14.46 55 14 46 1.55-14.46 p=0.012 p0012 012 15.2 152 2 1.2129.20 1212920 1.21 29.20 21 29 20 1.21-29.20 p=0.035. p0035 p=0.035 035 p=0.035) 3 3.4 34 4 0.626.10 062610 0.62 6.10 62 10 0.62-6.10 p=0.018 p0018 018 2.9 2.023.86 202386 2.02 3.86 02 86 2.02-3.86 p<0.001. p0001 p<0.001 001 p<0.001) adults selfinflicted self inflicted strategies women 19 202 39 5. 289 0.289.9 02899 028 0.2 992 9.9 0.28-9.9 p003 p=0.03 03 6. 5514 1.5514.4 155144 155 1.5 1446 14.4 1.55-14.4 p=0.01 p001 01 15. 2129 1.2129.2 121292 121 1.2 2920 29.2 1.21-29.2 3. 626 0.626.1 06261 062 0.6 610 6.1 0.62-6.1 2. 023 2.023.8 20238 2.0 386 3.8 8 2.02-3.8 p000 p<0.00 00 0.289. 0289 0. 99 9. 0.28-9. p00 p=0.0 551 1.5514. 15514 1. 144 14. 1.55-14. 212 1.2129. 12129 12 292 29. 1.21-29. 0.626. 0626 06 61 0.62-6. 2.023. 2023 38 2.02-3. p<0.0 0.289 0.28-9 p0 p=0. 1.5514 1551 1.55-14 1.2129 1212 1.21-29 0.626 0.62-6 2.023 2.02-3 p<0. 0.28- p=0 1.551 1.55-1 1.212 1.21-2 0.62- 2.02- p<0 p= 1.55- 1.21- p<

ABSTRACT In equatorial Brazil, the association of Burkitt lymphoma and Epstein–Barr virus manifests at high rates. Here, we report, for the first time, amplifications of aurora kinase genes (AURKA/B) in a patient with a history of periodontal abscess and the presence of a remaining nodule, diagnosed with Burkitt lymphoma and Epstein–Barr virus, and /HIV positive. The patient was a 38-year-old man who presented with a 2-week-old severe jaw pain and a 3-day-old severe bilateral headache. He had a history of human papilloma virus. Interphase FISH analysis showed AURKA and AURKB amplification. The patient’s condition worsened, progressing to death a month after the initial care. Changes in the MYCC and AURKA pathways are directly associated with genomic instability. Thus, MYCC rearrangements and higher expression of AURKA/B may be associated with therapy resistance, highlighting the importance of AURKA/B evaluation in Burkitt lymphoma. Brazil EpsteinBarr Epstein Barr rates Here report time AURKAB B (AURKA/B nodule HIV positive 38yearold yearold 38 year old 2weekold weekold 2 week 3dayold dayold 3 day headache amplification patients s worsened care instability Thus resistance

RESUMO Objetivos: Avaliar a eficácia e os efeitos da liberação das musculaturas de quadris subluxados de pacientes com SCZ. Métodos: Trata-se de um estudo do tipo retrospectivo com 29 pacientes CZS com subluxação do quadril, correspondendo a 55 quadris operados em um hospital público de Recife, Brasil. Foram avaliados os percentuais migratórios da cabeça femoral (PM) no pré-operatório e comparados com os resultados pós-operatórios de 6 e 12 meses. Resultados: Foram elegíveis 29 pacientes, representando 55 quadris avaliados. 19 eram do sexo feminino (65,5%), com média de idade de 31,45 meses (variando de 23 a 42 anos). 19 pacientes eram GMFCS nível V (65,5%), 34,5% eram nível IV e 20 dos 29 pacientes (69%) não apresentaram complicações. O PM teve redução absoluta de 11,6% (GMFCS IV) e de 13,31% (GMFCS V), nos primeiros seis meses. Após 12 meses, houve regressão do PM de 7,14% (GMFCS V) e de 11,25% (GMFCS IV) em relação aos valores pré-operatórios, sem diferença estatística entre os valores do PM apresentados entre 6 e 12 meses da cirurgia. Conclusões: A cirurgia foi eficaz em regredir o PM no período analisado e apresentou uma baixa taxa de complicações. Nível de Evidência III; Estudo retrospectivo comparativo. Objetivos SCZ Métodos Tratase Trata se 2 quadril 5 Recife Brasil (PM préoperatório pré operatório pósoperatórios pós operatórios 1 Resultados 65,5%, 655 65,5% , 65 (65,5%) 3145 31 45 31,4 variando 4 anos. anos . anos) 345 34 34,5 69% 69 (69% complicações 116 11 11,6 1331 13 13,31 V, 714 7 14 7,14 1125 25 11,25 préoperatórios, préoperatórios operatórios, pré-operatórios Conclusões III comparativo 65,5 (65,5% 314 3 31, 34, (69 11, 133 13,3 71 7,1 112 11,2 65, (65,5 (6 13, 7, (65, ( (65

ABSTRACT Objectives: Evaluate the efficacy and effects of releasing the muscles of subluxated hips of patients with SCZ. Methods: This is a retrospective study with 29 patients with subluxation of the hip, corresponding to 55 hips operated in a public hospital in Recife, Brazil. Preoperative femoral head migration (PM) percentages were evaluated and compared with 6- and 12-month postoperative results. Results: Twenty-nine patients were eligible, representing 55 hips evaluated. 19 were female (65.5%), with a mean age of 31.45 months (ranging from 23 to 42 years). 19 patients were GMFCS level V (65.5%), 34.5% were level IV, and 20 of the 29 patients (69%) had no complications. The PM had an absolute reduction of 11.6% (GMFCS IV) and 13.31% (GMFCS V) in the first six months. After 12 months, there was a regression of MP of 7.14% (GMFCS V) and 11.25% (GMFCS IV) compared to preoperative values, with no significant statistical difference among MP values presented between 6 and 12 months after surgery. Conclusions: The surgery was effective in PM regression during the analyzed period and presented a low complication rate. Level of Evidence III; Comparative retrospective study. Objectives SCZ Methods 2 hip 5 Recife Brazil (PM 12month month results Results Twentynine Twenty nine eligible 1 65.5%, 655 65.5% , 65 (65.5%) 3145 31 45 31.4 ranging 4 years. years . years) 345 34 34.5 IV 69% 69 (69% complications 116 11 11.6 1331 13 13.31 714 7 14 7.14 1125 25 11.25 Conclusions rate III 65.5 (65.5% 314 3 31. 34. (69 11. 133 13.3 71 7.1 112 11.2 65. (65.5 (6 13. 7. (65. ( (65

ABSTRACT Acute wound dressings can be based on PVA hydrogels, which present many characteristics of an ideal dressing, e.g., fluid uptake, a moisturized environment, etc. The lack of antimicrobial properties leads to the addition of natural active agents. The present work aims to manufacture and compare PVA gels loaded with Barbatimão bark extract, Leucaena bark extract, Aloe vera, and Lavender essential oil. They were characterized by FTIR, swelling tests, SEM, actives release. There were interactions between PVA and the active agents. The addition of Leucaena and Barbatimão increased the PVA ability to swell, but the opposite was found for Aloe vera and Lavender essential oil. PVA-Lavender essential oil samples presented interconnected pores, while samples with essential oil or extracts presented high crystallinity. Lavender essential oil and Aloe vera presented the highest release. The Barbatimão and Leucaena samples’ release may be related to the samples’ swelling, but the initial release of Aloe vera and Lavender samples was diffusion controlled by swelling. Their long-term release was dose-dependent for Aloe vera, while it was a non-Fickian diffusion for Lavender essential oil related to the hydrogel’s relaxation step. There is a synergistic effect when Aloe vera and Lavender essential oil are loaded in PVA hydrogels. hydrogels dressing eg e g e.g. uptake environment etc agents extract FTIR tests SEM swell PVALavender pores crystallinity longterm long term dosedependent dose dependent nonFickian non Fickian hydrogel s step e.g

Resumo As florestas desempenham um importante papel no ciclo do carbono. Dentre os fatores que podem afetar os estoques de carbono nos povoamentos florestais, o espaçamento de plantio tem grande relevância. O objetivo foi verificar o efeito do espaçamento na biomassa e no estoque de carbono em um povoamento de Anadenanthera peregrina (L.) Speg aos 56 meses de idade. O povoamento foi implantado nos espaçamentos 3 x 2 m, 3 x 3 m, 4 x 3 m, 4 x 4 m e 5 x 5 m. Quantificou-se a biomassa dos compartimentos acima do solo (madeira, galhos, folhas e casca) e da raiz, totalizando 16,42 e 6,68 Mg ha-1, respectivamente. A maior quantidade de biomassa e estoque de carbono ocorreu nos menores espaçamentos. A biomassa total foi duas vezes maior no espaçamento de 3 x 2 m em comparação com o espaçamento de 5 x 5 m. A biomassa abaixo do solo representou 40,93% da biomassa total. A ordem de participação dos componentes na biomassa aérea total foi galhos (44,99%), madeira (40,77%), folhas (13,99%) e casca (4,90%). Os espaçamentos mais densos (3 x 2 e 3 x 3 m) apresentaram maiores valores de biomassa e estoque de carbono do que os espaçamentos mais amplos (4 x 3 m, 4 x 4 m e 5 x 5 m). Não houve efeito do espaçamento de plantio sobre o estoque de carbono na necromassa e no solo. florestais relevância L. L (L. idade Quantificouse Quantificou se madeira, (madeira raiz 1642 16 42 16,4 668 6 68 6,6 ha1, ha1 ha 1, 1 ha-1 respectivamente 4093 40 93 40,93 44,99%, 4499 44,99% , 44 99 (44,99%) 40,77%, 4077 40,77% 77 (40,77%) 13,99% 1399 13 (13,99% 4,90%. 490 4,90% . 90 (4,90%) ( (L 164 16, 66 6, ha- 409 9 40,9 449 44,99 (44,99% 407 40,77 7 (40,77% 13,99 139 (13,99 49 4,90 (4,90% 40, 44,9 (44,99 40,7 (40,77 13,9 (13,9 4,9 (4,90 44, (44,9 (40,7 13, (13, 4, (4,9 (44, (40, (13 (4, (44 (40 (1

Abstract Forests play a crucial role in the global carbon cycle. Among the factors that can affect carbon stocks in forest stands, planting spacing stands out. This study verified the effect of spacing on biomass and carbon stock in a stand of Anadenanthera peregrina (L.) Speg at 56 months of age. They were planted with 3 x 2 m, 3 x 3 m, 4 x 3 m, 4 x 4 m and 5 x 5 m spacings. The biomass of the above-ground compartments (stem, branches, leaves and bark) and root biomass was quantified, totalling 16.42 and 6.68 Mg ha-1, respectively. The largest amount of biomass and carbon stock occurred in the denser spacings. Total biomass was twice as large at 3 x 2 m spacing compared to 5 x 5 m spacing. The root biomass represented 40.93% of the total biomass. The order of participation of the components in the total aboveground biomass was branches (44.99%), stem (40.77%), leaves (13.99%) and bark (4.90%). The denser spacings (3 x 2 m and 3 x 3 m) showed higher values of biomass and carbon stock than the wide spacings (4 x 3 m, 4 x 4 m and 5 x 5 m). There was no effect of planting spacing on carbon stock in necromass and soil. cycle out L. L (L. age above ground stem, (stem quantified 1642 16 42 16.4 668 6 68 6.6 ha1, ha1 ha 1, 1 ha-1 respectively 4093 40 93 40.93 44.99%, 4499 44.99% , 44 99 (44.99%) 40.77%, 4077 40.77% 77 (40.77%) 13.99% 1399 13 (13.99% 4.90%. 490 4.90% . 90 (4.90%) ( m. soil (L 164 16. 66 6. ha- 409 9 40.9 449 44.99 (44.99% 407 40.77 7 (40.77% 13.99 139 (13.99 49 4.90 (4.90% 40. 44.9 (44.99 40.7 (40.77 13.9 (13.9 4.9 (4.90 44. (44.9 (40.7 13. (13. 4. (4.9 (44. (40. (13 (4. (44 (40 (1