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ABSTRACT This study aimed to evaluate the productive and reproductive performance and the nutritional metabolic condition of ewes supplemented at different stages of gestation in a synchronized reproduction system. Fourty Santa Inês × Dorper crossbreed ewes, pregnant with an average age of ten months and two previous births, were distributed in a completely randomized design, with four treatments: mineral salt, supplementation started 20 days before the estrus synchronization (ES) protocol, supplementation from confirmation of pregnancy (60 days after ES), and supplementation in the final third of gestation (90 days after ES). The adoption of supplementation strategies during the beginning, middle, or end of pregnancy changed the intake and digestibility of dry matter (g/day), with a reduction of 10.53 and 9.14%, respectively, for the mineral salt treatment, in addition to organic matter, crude protein, neutral detergent fiber, acid detergent fiber, non-fibrous carbohydrates, ether extract, and total digestible nutrients, as well as protein, energy, and mineral profiles. There was no difference in the number of ovulations and reproductive and productive performance using supplementation alternatives. Supplementation strategies during the gestation stages influence the intake and digestibility of nutrients, as well as the animal metabolic profiles. However, it does not change reproductive and productive performance. system births design treatments 2 ES (ES protocol 60 (6 ES, , ES) 90 (9 ES. . beginning middle g/day, gday g/day g day (g/day) 1053 10 53 10.5 914 9 14 9.14% respectively treatment protein fiber nonfibrous non fibrous carbohydrates extract nutrients energy profiles alternatives However 6 ( (g/day 105 1 5 10. 91 9.14 9.1 9.