Abstract One of the crucial aspects to be considered for successful in vitro production (IVP) of embryos is the composition of the various media used throughout the stages of this reproductive biotechnology. The cell culture media employed should fulfill the metabolic requirements of both gametes during oocyte maturation and sperm development, as well as the embryo during its initial cell divisions. Most IVP protocols incorporate blood serum into the media composition as a source of hormones, proteins, growth factors, and nutrients. Numerous studies have suggested Platelet-Rich Plasma (PRP) as a substitute for fetal sera in cell culture, particularly for stem cells. Therefore, the objective of this study is to assess the potential use of PRP as a replacement for fetal bovine serum (FBS) during oocyte maturation for in vitro production of bovine embryos. During in vitro maturation (IVM), cumulus-oocyte complexes (COCs) were allocated into the following experimental groups: Group G1 (IVM medium with 5% PRP); Group G2 (MIV medium with 5% PRP and 5% SFB); Group G3 (MIV medium with 5% SFB); and Group G4 (MIV medium without either PRP or SFB). Subsequently, the cumulus-oocyte complexes were fertilized with semen from a single bull, and the resulting zygotes were cultured for seven days. Cleavage and blastocyst formation rates were assessed on days 2 and 7 of embryonic development, respectively. The quality of matured COCs was also evaluated by analyzing the gene expression of HSP70, an important protein associated with cellular stress. The results demonstrated that there were no significant differences among the experimental groups in terms of embryo production rates, both in the initial cleavage stages and blastocyst formation (except for the G4 group, which exhibited a lower blastocyst formation rate on D7, as expected). This indicates that PRP could be a cost-effective alternative to SFB in the IVP of embryos. (IVP biotechnology development divisions hormones proteins factors nutrients PlateletRich Platelet Rich (PRP cells Therefore FBS (FBS IVM, IVM , (IVM) cumulusoocyte cumulus (COCs G 5 PRP) MIV SFB) SFB. . Subsequently bull respectively HSP70 HSP stress except group D7 D expected. expected expected) costeffective cost effective HSP7

Abstract This study evaluated the survival probabilities of two lithia-based glass-ceramics after final crystallization in a microwave furnace using conventional crystallization as a reference. Disc-shaped samples of a lithium silicate (LS, Celtra Duo) and a lithium disilicate (LD, e.max CAD) were prepared and divided into two groups according to the crystallization method (n = 30): microwave (M) or conventional furnaces (C). The biaxial flexural strength test was used to determine the fatigue test profile and its parameters. Then, specimens were submitted to an accelerated life test (step stress) using three profile levels – mild, moderate, and aggressive – varying the load increments and the number of cycles until fracture (4 Hz). Survival data were used to calculate Weibull’s beta (β) value and reliability of the assigned missions. Scanning electron microscopy was employed to analyze surface morphology, fracture characteristics, and failure patterns. Beta (β) values for the LS-C, LS-M, LD-C, and LD-M groups were 2.65, 0.25, 0.62, and 0.3, respectively. Similar reliability was observed in all groups after 50,000 cycles at 100 and 150 Mpa. At 200 Mpa, the crystallization method did not affect the reliability within LS or LD. However, LD showed greater reliability than LS when crystallized by microwave energy. Thus, microwave energy can be suggested as an alternative to the process of conventional lithia-based glass-ceramics crystallization without damaging their survival probabilities. lithiabased lithia based glassceramics glass ceramics reference Discshaped Disc shaped LS, (LS Duo LD, (LD emax e max CAD n 30 30) M (M C. C . (C) parameters Then step stress mild moderate 4 ( Hz. Hz Hz) Weibulls Weibull s β (β missions morphology characteristics patterns LSC, LSC C, LS-C LSM, LSM M, LS-M LDC, LDC LD-C LDM 265 2 65 2.65 025 0 25 0.25 062 62 0.62 03 3 0.3 respectively 50000 50 000 50,00 10 15 Mpa 20 However Thus (C 26 6 2.6 02 0.2 06 0.6 0. 5000 5 00 50,0 1 2. 500 50,

Abstract In reproductive technologies, uncovering the molecular aspects of oocyte and embryo competence under different conditions is crucial for refining protocols and enhancing efficiency. RNA-seq generates high-throughput data and provides transcriptomes that can undergo additional computational analyses. This study presented the transcriptomic profiles of in vitro matured oocytes and blastocysts produced in vitro from buffalo crossbred (Bubalus bubalis), coupled with gene co-expression and module preservation analysis. Cumulus Oophorus Complexes, obtained from slaughterhouse-derived ovaries, were subjected to in vitro maturation to yield metaphase II oocytes (616) or followed in vitro fertilization and culture to yield blastocysts for sequencing (526). Oocyte maturation (72%, ±3.34 sd) and embryo development (21.3%, ±4.18 sd) rates were obtained from three in vitro embryo production routines following standard protocols. Sequencing of 410 metaphase II oocytes and 70 hatched blastocysts (grade 1 and 2) identified a total of 13,976 genes, with 62% being ubiquitously expressed (8,649). Among them, the differentially expressed genes (4,153) and the strongly variable genes with the higher expression (fold-change above 11) were highlighted in oocytes (BMP15, UCHL1, WEE1, NLRPs, KPNA7, ZP2, and ZP4) and blastocysts (APOA1, KRT18, ANXA2, S100A14, SLC34A2, PRSS8 and ANXA2) as representative indicators of molecular quality. Additionally, genes exclusively found in oocytes (224) and blastocysts (2,200) with specific biological functions were identified. Gene co-expression network and module preservation analysis revealed strong preservation of functional modules related to exosome components, steroid metabolism, cell proliferation, and morphogenesis. However, cell cycle and amino acid transport modules exhibited weak preservation, which may reflect differences in embryo development kinetics and the activation of cell signaling pathways between buffalo and bovine. This comprehensive transcriptomic profile serves as a valuable resource for assessing the molecular quality of buffalo oocytes and embryos in future in vitro embryo production assays. technologies efficiency RNAseq RNA seq highthroughput high throughput analyses Bubalus bubalis, bubalis , bubalis) coexpression co Complexes slaughterhousederived slaughterhouse derived ovaries 616 (616 526. 526 . (526) 72%, 72 (72% 334 3 34 ±3.3 sd 21.3%, 213 21 (21.3% 418 4 18 ±4.1 41 7 grade 2 13976 13 976 13,97 62 8,649. 8649 8,649 8 649 (8,649) them 4,153 4153 153 (4,153 foldchange fold change 11 BMP15, BMP15 BMP (BMP15 UCHL1 UCHL WEE1 WEE NLRPs KPNA7 KPNA ZP2 ZP ZP4 APOA1, APOA1 APOA (APOA1 KRT18 KRT ANXA2 ANXA S100A14 SA S A SLC34A2 SLCA SLC PRSS Additionally 224 (224 2,200 2200 200 (2,200 components metabolism proliferation morphogenesis However bovine assays 61 (61 52 (526 72% (72 33 ±3. 21.3% (21.3 ±4. 1397 97 13,9 6 864 8,64 64 (8,649 4,15 415 15 (4,15 BMP1 (BMP1 (APOA KRT1 S100A1 SLC34A 22 (22 2,20 220 20 (2,20 (6 5 (52 (7 ±3 21.3 (21. ±4 139 9 13, 86 8,6 (8,64 4,1 (4,1 (BMP S100A (2 2,2 (2,2 ( (5 ± 21. (21 8, (8,6 4, (4, 2, (2, (8, (4 (8

Abstract Introduction: Postoperative nausea and vomiting is still a common complication. Serotonin receptor antagonists are commonly used in clinical practice for antiemetic prophylaxis. Interin-dividual variations in drug response, including single nucleotide polymorphisms, are related to pharmacokinetic and pharmacodynamic changes in these drugs and may lead to a poor therapeutic response. This study aimed to evaluate the influence of CYP2D6 isoenzyme and ABCB1 gene polymorphisms on the frequency of postoperative nausea and vomiting with the use of ondansetron or palonosetron. Methods: A randomized, double-blind clinical trial including 82 women aged 60 years or over undergoing laparoscopic cholecystectomy was conducted. Patients were randomized to receive either ondansetron or palonosetron for postoperative nausea and vomiting prophylaxis. DNA was extracted from saliva. Genetic polymorphisms were analyzed by real-time polymerase chain reaction. The following polymorphisms were analyzed: rs3892097 C/T, rs1128503 A/G, rs16947A/G, rs1065852 A/G, rs1045642 A/G, rs2032582 C/A, and rs20325821 C/A. Results: Overall, vomiting, and severe nausea occurred in 22.5% and 57.5% of patients, respectively. In the palonosetron group, patients with the GG genotype (rs16947 A/G) experienced more severe nausea (p = 0.043). In the ondansetron group, patients with the M genotype (rs16947 A/G) presented mild nausea (p = 0.034), and those with the AA genotype (rs1065852 A/G) experienced more vomiting (p = 0.034). Conclusion: A low antiemetic response was observed with ondansetron in the presence of the AA genotype (rs16947 A/G) and the AA genotype (rs1065852 A/G), and a low therapeutic response was found with palonosetron in the presence of the GG genotype (rs16947 A/G) in laparoscopic cholecystectomy. Register: ClinicalTrials.gov. Introduction complication prophylaxis Interindividual Interin dividual CYPD CYP D CYP2D ABCB Methods doubleblind double blind 8 6 conducted saliva realtime real time reaction rs rs389209 CT C T C/T rs112850 AG G A/G rs16947AG rsAG rs16947A rs16947A/G rs106585 rs104564 rs203258 CA C/A Results Overall 225 22 5 22.5 575 57 57.5 respectively group rs16947 (rs1694 p 0.043. 0043 0.043 . 0 043 0.043) 0.034, 0034 0.034 , 034 0.034) (rs106585 0.034. Conclusion Register ClinicalTrialsgov ClinicalTrials gov ClinicalTrials.gov rs38920 rs11285 rsA rs10658 rs10456 rs20325 2 22. 57. rs1694 (rs169 004 0.04 04 003 0.03 03 (rs10658 rs3892 rs1128 rs1065 rs1045 rs2032 rs169 (rs16 00 0.0 (rs1065 rs389 rs112 rs106 rs104 rs203 rs16 (rs1 0. (rs106 rs38 rs11 rs10 rs20 rs1 (rs (rs10 rs3 rs2

Resumo O estudo realizou uma revisão do perfil parasitológico de vegetais, de 2001 a 2021, considerando o tipo, consumo e cultivo, global. Foram pesquisadas as bases MEDLINE, SciELO, Web of Science, Science Direct e Scopus com os termos "Detection OR Prevalence OR Incidence OR occurrence OR contamination AND vegetable OR fruit AND Helminth OR egg OR Parasite OR cysts OR protozoa". Foram encontrados 16.600 artigos, 117 dos quais foram revisados. Das 391.291 amostras, 3,85% (15.095) estavam contaminadas por parasitos. Entre as positivas, 30,10% (4.543/15.095) continham enteroparasitos comumente de origem humana e 58,78% (8.873/15.095) eram originadas de mercados. Poucos artigos mencionaram o tipo de cultivo, mas entre esses, o convencional apresentou maior contaminação (42,34%; 224/529). Vegetais herbáceos foram os mais contaminados (56,84%; 8.580/15.095). Ascaris lumbricoides foi encontrado em 10,16% (1.535/15.095) das amostras. Alface foi o vegetal mais contaminado (20,43%; 3.084/15.095). vegetais 200 2021 cultivo global MEDLINE SciELO Detection protozoa. protozoa . protozoa" 16600 16 600 16.60 11 revisados 391291 391 291 391.29 amostras 385 3 85 3,85 15.095 15095 15 095 (15.095 parasitos positivas 3010 30 10 30,10 4.543/15.095 454315095 4 543 (4.543/15.095 5878 58 78 58,78 8.873/15.095 887315095 8 873 (8.873/15.095 mercados esses 42,34% 4234 42 34 (42,34% 224/529. 224529 224/529 224 529 224/529) 56,84% 5684 56 84 (56,84% 8.580/15.095. 858015095 8.580/15.095 580 8.580/15.095) 1016 10,16 1.535/15.095 153515095 1 535 (1.535/15.095 20,43% 2043 20 43 (20,43% 3.084/15.095. 308415095 3.084/15.095 084 3.084/15.095) 202 1660 60 16.6 39129 39 29 391.2 38 3,8 15.09 1509 09 (15.09 301 30,1 4.543/15.09 45431509 54 (4.543/15.09 587 5 7 58,7 8.873/15.09 88731509 87 (8.873/15.09 42,34 423 (42,34 22452 224/52 22 52 56,84 568 (56,84 85801509 8.580/15.09 101 10,1 1.535/15.09 15351509 53 (1.535/15.09 20,43 204 2 (20,43 30841509 3.084/15.09 08 166 6 16. 3912 391. 3, 15.0 150 0 (15.0 30, 4.543/15.0 4543150 (4.543/15.0 58, 8.873/15.0 8873150 (8.873/15.0 42,3 (42,3 2245 224/5 56,8 (56,8 8580150 8.580/15.0 10, 1.535/15.0 1535150 (1.535/15.0 20,4 (20,4 3084150 3.084/15.0 15. (15. 4.543/15. 454315 (4.543/15. 8.873/15. 887315 (8.873/15. 42, (42, 224/ 56, (56, 858015 8.580/15. 1.535/15. 153515 (1.535/15. 20, (20, 308415 3.084/15. (15 4.543/15 45431 (4.543/15 8.873/15 88731 (8.873/15 (42 (56 85801 8.580/15 1.535/15 15351 (1.535/15 (20 30841 3.084/15 (1 4.543/1 4543 (4.543/1 8.873/1 8873 (8.873/1 (4 (5 8580 8.580/1 1.535/1 1535 (1.535/1 (2 3084 3.084/1 ( 4.543/ 454 (4.543/ 8.873/ 887 (8.873/ 858 8.580/ 1.535/ 153 (1.535/ 308 3.084/ 4.543 45 (4.543 8.873 88 (8.873 8.580 1.535 (1.535 3.084 4.54 (4.54 8.87 (8.87 8.58 1.53 (1.53 3.08 4.5 (4.5 8.8 (8.8 8.5 1.5 (1.5 3.0 4. (4. 8. (8. 1. (1. 3. (8

Abstract The study conducted a review of the parasitological profile of vegetables from 2001 to 2021, considering the type, consumption, and cultivation, globally. The databases searched included MEDLINE, SciELO, Web of Science, Science Direct, and Scopus using the terms "Detection OR Prevalence OR Incidence OR occurrence OR contamination AND vegetable OR fruit AND Helminth OR egg OR Parasite OR cysts OR protozoa". A total of 16,600 articles were found, 117 of which were reviewed. Of the 391,291 samples, 3.85% (15,095) were contaminated by parasites. Among those positive, 30.10% (4,543/15,095) contained enteroparasites commonly of human origin and 58.78% (8,873/15,095) came from markets. Few articles mentioned the cultivation type, but among those, conventional cultivation showed more contamination (42.34%; 224/529). Herbaceous vegetables were the most contaminated (56.84%; 8,580/15,095. Ascaris lumbricoides was found in 10.16% (1,535/15,095) of the samples. Lettuce was the most contaminated (20.43%; 3,084/15,095). 200 2021 type consumption globally MEDLINE SciELO Direct Detection protozoa. protozoa . protozoa" 16600 16 600 16,60 11 reviewed 391291 391 291 391,29 samples 385 3 85 3.85 15,095 15095 15 095 (15,095 parasites positive 3010 30 10 30.10 4,543/15,095 454315095 4 543 (4,543/15,095 5878 58 78 58.78 8,873/15,095 887315095 8 873 (8,873/15,095 markets 42.34% 4234 42 34 (42.34% 224/529. 224529 224/529 224 529 224/529) 56.84% 5684 56 84 (56.84% 858015095 580 8,580/15,095 1016 10.16 1,535/15,095 153515095 1 535 (1,535/15,095 20.43% 2043 20 43 (20.43% 3,084/15,095. 308415095 3,084/15,095 084 3,084/15,095) 202 1660 60 16,6 39129 39 29 391,2 38 3.8 15,09 1509 09 (15,09 301 30.1 4,543/15,09 45431509 54 (4,543/15,09 587 5 7 58.7 8,873/15,09 88731509 87 (8,873/15,09 42.34 423 (42.34 22452 224/52 22 52 56.84 568 (56.84 85801509 8,580/15,09 101 10.1 1,535/15,09 15351509 53 (1,535/15,09 20.43 204 2 (20.43 30841509 3,084/15,09 08 166 6 16, 3912 391, 3. 15,0 150 0 (15,0 30. 4,543/15,0 4543150 (4,543/15,0 58. 8,873/15,0 8873150 (8,873/15,0 42.3 (42.3 2245 224/5 56.8 (56.8 8580150 8,580/15,0 10. 1,535/15,0 1535150 (1,535/15,0 20.4 (20.4 3084150 3,084/15,0 15, (15, 4,543/15, 454315 (4,543/15, 8,873/15, 887315 (8,873/15, 42. (42. 224/ 56. (56. 858015 8,580/15, 1,535/15, 153515 (1,535/15, 20. (20. 308415 3,084/15, (15 4,543/15 45431 (4,543/15 8,873/15 88731 (8,873/15 (42 (56 85801 8,580/15 1,535/15 15351 (1,535/15 (20 30841 3,084/15 (1 4,543/1 4543 (4,543/1 8,873/1 8873 (8,873/1 (4 (5 8580 8,580/1 1,535/1 1535 (1,535/1 (2 3084 3,084/1 ( 4,543/ 454 (4,543/ 8,873/ 887 (8,873/ 858 8,580/ 1,535/ 153 (1,535/ 308 3,084/ 4,543 45 (4,543 8,873 88 (8,873 8,580 1,535 (1,535 3,084 4,54 (4,54 8,87 (8,87 8,58 1,53 (1,53 3,08 4,5 (4,5 8,8 (8,8 8,5 1,5 (1,5 3,0 4, (4, 8, (8, 1, (1, 3, (8

RESUMO Objetivo: Analisar os fatores associados ao aumento da violência doméstica entre professores no período inicial na pandemia. Métodos: Estudo transversal e analítico, do tipo websurvey , realizado com professores da educação básica pública de Minas Gerais, Brasil. A coleta de dados ocorreu de agosto a setembro de 2020, via formulário digital. A variável dependente foi o autorrelato da violência doméstica. Utilizou-se a Regressão de Poisson. Resultados: Participaram do estudo 539 professores em situação de violência doméstica na pandemia, dos quais 6,3% (n = 34) diminuíram um pouco e muito, 58,3% (n = 314) permaneceram o mesmo e 35,4% (n = 191) aumentaram um pouco e muito. Na análise ajustada, observou-se maior prevalência do aumento da violência doméstica entre os professores que referiram dificuldade com o trabalho docente (RP = 1,38; IC95% 1,01;1,89); com adesão total ao distanciamento social (RP = 1,33; IC95% 1,01;1,76); piora no estado de saúde (RP = 1,70; IC95% 1,23;2,36) e que se sentiram tristes ou deprimidos muitas vezes ou sempre (RP = 1,57; IC95% 1,15;2,16). Conclusão: O aumento da violência doméstica da pandemia em professores foi associado a características laborais e condições de saúde mental. Objetivo Métodos analítico Gerais Brasil 2020 digital Utilizouse Utilizou Poisson Resultados 53 63 6 3 6,3 n 34 muito 583 58 58,3 314 354 35 4 35,4 191 ajustada observouse observou RP 1,38 138 1 38 IC95 IC 1,011,89 101189 1,01 1,89 01 89 1,01;1,89) 1,33 133 33 1,011,76 101176 1,76 76 1,01;1,76) 1,70 170 70 1,232,36 123236 1,23 2,36 23 2 36 1,23;2,36 1,57 157 57 1,152,16. 115216 1,15 2,16 . 15 16 1,15;2,16) Conclusão mental 202 5 6, 58, 31 35, 19 1,3 13 IC9 011 1,011,8 10118 101 1,0 189 1,8 0 8 1,01;1,89 1,011,7 10117 176 1,7 7 1,01;1,76 17 232 1,232,3 12323 123 1,2 236 2,3 1,23;2,3 1,5 152 1,152,16 11521 115 1,1 216 2,1 1,15;2,16 20 1, 1,011, 1011 10 18 1,01;1,8 1,01;1,7 1,232, 1232 12 2, 1,23;2, 1,152,1 1152 11 21 1,15;2,1 1,011 1,01;1, 1,232 1,23;2 1,152, 1,15;2, 1,01;1 1,23; 1,152 1,15;2 1,01; 1,15;

ABSTRACT Objective: To analyze the factors associated with the increase in domestic violence among teachers in the initial period of the pandemic. Methods: Cross-sectional and analytical study, of the websurvey type, carried out with teachers of public basic education in Minas Gerais, Brazil. Data collection took place from August to September 2020, via a digital form. The dependent variable was self-reported domestic violence. Poisson regression was used. Results: 539 teachers participated in the study in situations of domestic violence in the pandemic, of which 6.3% (n = 34) decreased a little and a lot, 58.3% (n = 314) remained the same and 35.4% (n = 191) increased a little and a lot. In the adjusted analysis, a higher prevalence of increased domestic violence was observed among teachers who reported difficulty with teaching work (PR = 1.38; 95%CI 1.01;1.89); with full adherence to social distancing (PR = 1.33; 95%CI 1.01;1.76); worsening of health status (PR = 1.70; 95%CI 1.23;2.36) and in teachers who felt sad or depressed many times or always (PR = 1.57; 95%CI 1.15;2.16). Conclusion: The increase in domestic violence of the pandemic in teachers was associated with work characteristics and mental health conditions. Objective Methods Crosssectional Cross sectional type Gerais Brazil 2020 form selfreported self used Results 53 63 6 3 6.3 n 34 lot 583 58 58.3 314 354 35 4 35.4 191 analysis PR 1.38 138 1 38 95CI CI 95 1.011.89 101189 1.01 1.89 01 89 1.01;1.89) 1.33 133 33 1.011.76 101176 1.76 76 1.01;1.76) 1.70 170 70 1.232.36 123236 1.23 2.36 23 2 36 1.23;2.36 1.57 157 57 1.152.16. 115216 1.15 2.16 . 15 16 1.15;2.16) Conclusion conditions 202 5 6. 58. 31 35. 19 1.3 13 9 011 1.011.8 10118 101 1.0 189 1.8 0 8 1.01;1.89 1.011.7 10117 176 1.7 7 1.01;1.76 17 232 1.232.3 12323 123 1.2 236 2.3 1.23;2.3 1.5 152 1.152.16 11521 115 1.1 216 2.1 1.15;2.16 20 1. 1.011. 1011 10 18 1.01;1.8 1.01;1.7 1.232. 1232 12 2. 1.23;2. 1.152.1 1152 11 21 1.15;2.1 1.011 1.01;1. 1.232 1.23;2 1.152. 1.15;2. 1.01;1 1.23; 1.152 1.15;2 1.01; 1.15;

Resumo Objetivo: analisar a prevalência do aumento da automedicação durante a pandemia de COVID-19 entre professores da educação básica pública e fatores associados. Métodos: inquérito epidemiológico do tipo websurvey, realizado com professores da educação básica pública de Minas Gerais. A coleta de dados ocorreu de agosto a setembro de 2020 via formulário online. A variável dependente foi a automedicação durante a pandemia. Foi utilizada a Regressão de Poisson, com variância robusta. Resultados: participaram do estudo 15.641 professores de 795 cidades mineiras, 81,9% eram do sexo feminino. Observou-se que 14,5% dos professores aumentaram a automedicação durante a pandemia, entre eles houve maior prevalência entre as mulheres (Razão de Prevalência [RP]=1,25; Intervalo de Confiança de 95% [IC95%]=1,12;1,40), professores com menos de 60 anos (RP=1,48; IC95%=1,12;1,95), residentes da área urbana (RP=1,15; IC95%=1,02;1,29), insatisfeitos com o trabalho docente (RP=1,60; IC95%=1,41;1,82), com pior padrão alimentar (RP=1,44; IC95%=1,33;1,56), parte do grupo de risco para a COVID-19 (RP=1,18; IC95%=1,10;1,27), com problemas de sono (RP=2,10; IC95%=1,85;2,38), tristes ou regularmente deprimidos (RP=6,29; IC95%=4,08;9,69) e aqueles que apresentaram muito medo da COVID-19 (RP=1,39; IC95%=1,23;1,57). Conclusão: a automedicação esteve associada a características sociodemográficas, hábitos de vida, condições de saúde e indiferença ou insatisfação com o trabalho, configurando-se como um problema de saúde entre docentes. Objetivo COVID19 COVID 19 COVID-1 associados Métodos websurvey Gerais 202 online Poisson robusta Resultados 15641 15 641 15.64 79 mineiras 819 81 9 81,9 feminino Observouse Observou se 145 14 5 14,5 Razão RP=1,25 RP125 RP =1,25 1 25 [RP]=1,25 95 IC95%=1,121,40, IC95112140 IC IC95% =1,12 1,40 , IC95 12 40 [IC95%]=1,12;1,40) 6 RP=1,48 RP148 48 (RP=1,48 IC95%=1,121,95, IC95112195 IC95%=1,12 1,95 IC95%=1,12;1,95) RP=1,15 RP115 (RP=1,15 IC95%=1,021,29, IC95102129 IC95%=1,02 1,29 02 29 IC95%=1,02;1,29) RP=1,60 RP160 (RP=1,60 IC95%=1,411,82, IC95141182 IC95%=1,41 1,82 41 82 IC95%=1,41;1,82) RP=1,44 RP144 44 (RP=1,44 IC95%=1,331,56, IC95133156 IC95%=1,33 1,56 33 56 IC95%=1,33;1,56) RP=1,18 RP118 18 (RP=1,18 IC95%=1,101,27, IC95110127 IC95%=1,10 1,27 10 27 IC95%=1,10;1,27) RP=2,10 RP210 2 (RP=2,10 IC95%=1,852,38, IC95185238 IC95%=1,85 2,38 85 38 IC95%=1,85;2,38) RP=6,29 RP629 (RP=6,29 IC95%=4,089,69 IC95408969 IC95%=4,08 9,69 4 08 69 IC95%=4,08;9,69 RP=1,39 RP139 39 (RP=1,39 IC95%=1,231,57. IC95123157 IC95%=1,23 1,57 . 23 57 IC95%=1,23;1,57) Conclusão sociodemográficas vida configurandose configurando docentes COVID1 COVID- 20 1564 64 15.6 7 8 81, 14, RP=1,2 RP12 125 =1,2 [RP]=1,2 121 IC95%=1,121,40 IC9511214 112 =1,1 140 1,4 IC9 [IC95%]=1,12;1,40 RP=1,4 RP14 (RP=1,4 IC95%=1,121,95 IC9511219 IC95112 IC95%=1,1 195 1,9 IC95%=1,12;1,95 RP=1,1 RP11 (RP=1,1 021 IC95%=1,021,29 IC9510212 IC95102 IC95%=1,0 129 1,2 0 IC95%=1,02;1,29 RP=1,6 RP16 (RP=1,6 411 IC95%=1,411,82 IC9514118 IC95141 IC95%=1,4 182 1,8 IC95%=1,41;1,82 331 IC95%=1,331,56 IC9513315 IC95133 IC95%=1,3 156 1,5 3 IC95%=1,33;1,56 101 IC95%=1,101,27 IC9511012 IC95110 127 IC95%=1,10;1,27 RP=2,1 RP21 (RP=2,1 852 IC95%=1,852,38 IC9518523 IC95185 IC95%=1,8 238 2,3 IC95%=1,85;2,38 RP=6,2 RP62 (RP=6,2 089 IC95%=4,089,6 IC9540896 IC95408 IC95%=4,0 969 9,6 IC95%=4,08;9,6 RP=1,3 RP13 (RP=1,3 231 IC95%=1,231,57 IC9512315 IC95123 IC95%=1,2 157 IC95%=1,23;1,57 15. RP=1, RP1 =1, [RP]=1, IC95%=1,121,4 IC951121 11 1, [IC95%]=1,12;1,4 (RP=1, IC95%=1,121,9 IC9511 IC95%=1, IC95%=1,12;1,9 IC95%=1,021,2 IC951021 IC9510 IC95%=1,02;1,2 IC95%=1,411,8 IC951411 IC9514 IC95%=1,41;1,8 IC95%=1,331,5 IC951331 IC9513 IC95%=1,33;1,5 IC95%=1,101,2 IC951101 IC95%=1,10;1,2 RP=2, RP2 (RP=2, IC95%=1,852,3 IC951852 IC9518 2, IC95%=1,85;2,3 RP=6, RP6 (RP=6, IC95%=4,089, IC954089 IC9540 IC95%=4, 96 9, IC95%=4,08;9, IC95%=1,231,5 IC951231 IC9512 IC95%=1,23;1,5 RP=1 =1 [RP]=1 IC95%=1,121, [IC95%]=1,12;1, (RP=1 IC951 IC95%=1 IC95%=1,12;1, IC95%=1,021, IC95%=1,02;1, IC95%=1,411, IC95%=1,41;1, IC95%=1,331, IC95%=1,33;1, IC95%=1,101, IC95%=1,10;1, RP=2 (RP=2 IC95%=1,852, IC95%=1,85;2, RP=6 (RP=6 IC95%=4,089 IC954 IC95%=4 IC95%=4,08;9 IC95%=1,231, IC95%=1,23;1, RP= = [RP]= IC95%=1,121 [IC95%]=1,12;1 (RP= IC95%= IC95%=1,12;1 IC95%=1,021 IC95%=1,02;1 IC95%=1,411 IC95%=1,41;1 IC95%=1,331 IC95%=1,33;1 IC95%=1,101 IC95%=1,10;1 IC95%=1,852 IC95%=1,85;2 IC95%=4,08; IC95%=1,231 IC95%=1,23;1 [RP] [IC95%]=1,12; (RP IC95%=1,12; IC95%=1,02; IC95%=1,41; IC95%=1,33; IC95%=1,10; IC95%=1,85; IC95%=1,23; [RP [IC95%]=1,12 [IC95%]=1,1 [IC95%]=1, [IC95%]=1 [IC95%]= [IC95%] [IC95% [IC95 [IC9 [IC

Abstract Objective: to analyse the prevalence of self-medication during the COVID-19 pandemic among primary education teachers and the associated factors. Methods: web-survey type of epidemiological survey performed with primary education teachers from public schools in Minas Gerais. Data collection occurred between August and September of 2020 via digital forms. The dependent variable was self-medication during the pandemic. It was analyzed by Poisson Regression, with robust variance estimation. Results: a total of 15,641 teachers from 795 cities in Minas Gerais, 81.9% female, participated in the study. It was observed that 14.5% of teachers increased the self-medication during pandemic, among them, the highest prevalence was between women (Prevalence Ratio [PR]=1.25; 95% of Confidence Interval [95%CI]=1.12;1.40), under 60 years old (PR=1.48; 95%CI=1.12;1.95), living in the urban area (PR=1.15; 95%CI=1.02;1.29), dissatisfied with the teaching work (PR=1.60; 95%CI=1.41;1.82), with worse dietary pattern (PR=1.44; 95%CI=1.33;1.56), outside the risk group for COVID-19 (PR=1.18; 95%CI=1.10;1.27), with sleep problems (PR=2.10; 95%CI=1.85;2.38), sad or regularly depressed (PR=6.29; 95%CI=4.08;9.69), and very afraid of COVID-19 (PR=1.39; 95%CI=1.23;1.57). Conclusion: self-medication was associated with sociodemographic characteristics, life habits, health conditions, and indifference or dissatisfaction with the work, characterized as a health problem among teachers. Objective selfmedication self medication COVID19 COVID 19 COVID-1 factors Methods websurvey web Gerais 202 forms Regression estimation Results 15641 15 641 15,64 79 819 81 9 81.9 female study 145 14 5 14.5 them Prevalence PR=1.25 PR125 PR =1.25 1 25 [PR]=1.25 95 95%CI=1.121.40, 95CI112140 CI 95%CI =1.12 1.40 , 12 40 [95%CI]=1.12;1.40) 6 PR=1.48 PR148 48 (PR=1.48 95%CI=1.121.95, 95CI112195 95%CI=1.12 1.95 95%CI=1.12;1.95) PR=1.15 PR115 (PR=1.15 95%CI=1.021.29, 95CI102129 95%CI=1.02 1.29 02 29 95%CI=1.02;1.29) PR=1.60 PR160 (PR=1.60 95%CI=1.411.82, 95CI141182 95%CI=1.41 1.82 41 82 95%CI=1.41;1.82) PR=1.44 PR144 44 (PR=1.44 95%CI=1.331.56, 95CI133156 95%CI=1.33 1.56 33 56 95%CI=1.33;1.56) PR=1.18 PR118 18 (PR=1.18 95%CI=1.101.27, 95CI110127 95%CI=1.10 1.27 10 27 95%CI=1.10;1.27) PR=2.10 PR210 2 (PR=2.10 95%CI=1.852.38, 95CI185238 95%CI=1.85 2.38 85 38 95%CI=1.85;2.38) PR=6.29 PR629 (PR=6.29 95%CI=4.089.69, 95CI408969 95%CI=4.08 9.69 4 08 69 95%CI=4.08;9.69) PR=1.39 PR139 39 (PR=1.39 95%CI=1.231.57. 95CI123157 95%CI=1.23 1.57 . 23 57 95%CI=1.23;1.57) Conclusion characteristics habits conditions COVID1 COVID- 20 1564 64 15,6 7 8 81. 14. PR=1.2 PR12 125 =1.2 [PR]=1.2 121 95%CI=1.121.40 95CI11214 95CI 112 =1.1 140 1.4 [95%CI]=1.12;1.40 PR=1.4 PR14 (PR=1.4 95%CI=1.121.95 95CI11219 95CI112 95%CI=1.1 195 1.9 95%CI=1.12;1.95 PR=1.1 PR11 (PR=1.1 021 95%CI=1.021.29 95CI10212 95CI102 95%CI=1.0 129 1.2 0 95%CI=1.02;1.29 PR=1.6 PR16 (PR=1.6 411 95%CI=1.411.82 95CI14118 95CI141 95%CI=1.4 182 1.8 95%CI=1.41;1.82 331 95%CI=1.331.56 95CI13315 95CI133 95%CI=1.3 156 1.5 3 95%CI=1.33;1.56 101 95%CI=1.101.27 95CI11012 95CI110 127 95%CI=1.10;1.27 PR=2.1 PR21 (PR=2.1 852 95%CI=1.852.38 95CI18523 95CI185 95%CI=1.8 238 2.3 95%CI=1.85;2.38 PR=6.2 PR62 (PR=6.2 089 95%CI=4.089.69 95CI40896 95CI408 95%CI=4.0 969 9.6 95%CI=4.08;9.69 PR=1.3 PR13 (PR=1.3 231 95%CI=1.231.57 95CI12315 95CI123 95%CI=1.2 157 95%CI=1.23;1.57 15, PR=1. PR1 =1. [PR]=1. 95%CI=1.121.4 95CI1121 11 1. [95%CI]=1.12;1.4 (PR=1. 95%CI=1.121.9 95CI11 95%CI=1. 95%CI=1.12;1.9 95%CI=1.021.2 95CI1021 95CI10 95%CI=1.02;1.2 95%CI=1.411.8 95CI1411 95CI14 95%CI=1.41;1.8 95%CI=1.331.5 95CI1331 95CI13 95%CI=1.33;1.5 95%CI=1.101.2 95CI1101 95%CI=1.10;1.2 PR=2. PR2 (PR=2. 95%CI=1.852.3 95CI1852 95CI18 2. 95%CI=1.85;2.3 PR=6. PR6 (PR=6. 95%CI=4.089.6 95CI4089 95CI40 95%CI=4. 96 9. 95%CI=4.08;9.6 95%CI=1.231.5 95CI1231 95CI12 95%CI=1.23;1.5 PR=1 =1 [PR]=1 95%CI=1.121. [95%CI]=1.12;1. (PR=1 95CI1 95%CI=1 95%CI=1.12;1. 95%CI=1.021. 95%CI=1.02;1. 95%CI=1.411. 95%CI=1.41;1. 95%CI=1.331. 95%CI=1.33;1. 95%CI=1.101. 95%CI=1.10;1. PR=2 (PR=2 95%CI=1.852. 95%CI=1.85;2. PR=6 (PR=6 95%CI=4.089. 95CI4 95%CI=4 95%CI=4.08;9. 95%CI=1.231. 95%CI=1.23;1. PR= = [PR]= 95%CI=1.121 [95%CI]=1.12;1 (PR= 95%CI= 95%CI=1.12;1 95%CI=1.021 95%CI=1.02;1 95%CI=1.411 95%CI=1.41;1 95%CI=1.331 95%CI=1.33;1 95%CI=1.101 95%CI=1.10;1 95%CI=1.852 95%CI=1.85;2 95%CI=4.089 95%CI=4.08;9 95%CI=1.231 95%CI=1.23;1 [PR] [95%CI]=1.12; (PR 95%CI=1.12; 95%CI=1.02; 95%CI=1.41; 95%CI=1.33; 95%CI=1.10; 95%CI=1.85; 95%CI=4.08; 95%CI=1.23; [PR [95%CI]=1.12 [95%CI]=1.1 [95%CI]=1. [95%CI]=1 [95%CI]= [95%CI] [95%CI

RESUMEN Objetivo comprender los desafíos de la práctica asistencial con intervenciones grupales en Centros de Atención Psicosocial de Alcohol y Drogas. Método investigación de intervención desarrollada con 30 profesionales de cuatro Centros de Atención Psicosocial de Alcohol y Drogas de un municipio del centro de Brasil de marzo a abril de 2019. Utilizamos un instrumento de caracterización profesional y ruedas de conversación para recolectar datos que fueron sometidos a la modalidad temática de análisis de contenido. Resultados: se evidenciaron algunos desafíos que permean la práctica con intervenciones grupales en CAPSad, desde la perspectiva de los profesionales, como estructura física inadecuada y escasez de recursos materiales; cuestiones relacionadas con aspectos de los usuarios como dificultad para incorporar y compromiso de grupos, jornada laboral incompatible y falta de recursos económicos para desplazamiento al servicio; factores d la competencia de los profesionales como no tener afinidad para trabajar con grupos, ausencia de formación específica, priorización de otras prácticas, desmotivación, ausencia de registros de atención y dificultad en la realización del alta de los usuarios y; aspectos de los procesos de trabajo como cultura organizacional ambulatoria, demanda muy grande, recursos humanos insuficientes, falta de supervisión externa, pocas ofertas de grupos terapéuticos y falta de criterio para la definición de coordinadores de grupo. Conclusión: lo vivido incluye cuestiones de estructura física inadecuada y recursos materiales deficientes, desafíos relacionados con los contextos de vida de los usuarios, competencia de los profesionales y factores de los procesos de trabajo de los servicios. 3 2019 contenido Resultados CAPSad servicio específica prácticas desmotivación ambulatoria grande insuficientes externa grupo Conclusión deficientes servicios 201 20 2

ABSTRACT Objective: to understand the challenges of care practice with group interventions Psychosocial Care Centers for Alcohol and Drugs. Method: qualitative intervention research developed with 30 professionals from four Alcohol and Psychosocial Drug Care Centers in a municipality in central Brazil from March to April 2019. We used a professional characterization instrument and conversation wheels to collect data that were submitted to the thematic modality of content analysis. Results: some challenges that permeate the practice with group interventions in CAPSad were evidenced, from the professionals' perspective, such as inadequate physical structure and scarcity of material resources; issues related to aspects of users such as difficulty in adhesion and commitment to groups, incompatible work schedules and lack of financial resources for travel to the centers; factors related to the competence of professionals as not having affinity to work with groups, absence of specific training, prioritization of other practices, demotivation, absence of care records and difficulty in performing the patient discharge and; aspects of work processes such as outpatient organizational culture, very high demand, insufficient human resources, lack of external supervision, few offers of therapeutic groups and lack of criteria for the definition of group coordinators. Conclusion: the challenges experienced include issues of inadequate physical structure and deficient material resources, difficulties related to the life contexts of users, competence of professionals and factors of the work processes of the services. Objective Drugs Method 3 2019 analysis Results evidenced perspective centers training practices demotivation culture demand supervision coordinators Conclusion services 201 20 2

RESUMO Objetivo: compreender os desafios da prática assistencial com intervenções grupais em Centros de Atenção Psicossocial Álcool e Drogas. Método: pesquisa-intervenção de abordagem qualitativa desenvolvida com 30 profissionais de quatro Centros de Atenção Psicossocial Álcool e Drogas de um município da região central do Brasil de março e abril de 2019. Utilizou-se instrumento de caracterização profissiográfica e rodas de conversa para coleta de dados que foram submetidos à análise de conteúdo, modalidade temática. Resultados: evidenciou-se alguns desafios que permeiam a prática com intervenções grupais em CAPSad, sob a ótica dos profissionais, como estrutura física inadequada e escassez de recursos materiais; questões ligadas a aspectos dos usuários como a dificuldade de adesão e comprometimento com os grupos, agenda de trabalho incompatível e falta de recursos financeiros para deslocamento ao serviço; fatores da competência dos profissionais como não ter afinidade de trabalhar com grupos, ausência de formação específica, priorização de outras práticas, desmotivação, ausência de registros dos atendimentos e dificuldade de realizar a alta dos usuários e; aspectos dos processos de trabalho como cultura organizacional ambulatorial, demanda muito grande, recursos humanos insuficientes, falta de supervisão externa, poucas ofertas de grupos terapêuticos e ausência de critérios para a definição de coordenadores de grupos. Conclusão: os desafios vivenciados englobam questões de estrutura física inadequada e recursos materiais deficitários, dificuldades ligadas aos contextos de vida dos usuários, competência dos profissionais e fatores dos processos de trabalho dos serviços. Objetivo Método pesquisaintervenção pesquisa intervenção 3 2019 Utilizouse Utilizou se conteúdo temática Resultados evidenciouse evidenciou CAPSad serviço específica práticas desmotivação ambulatorial grande insuficientes externa Conclusão deficitários serviços 201 20 2

Resumo Investigar o impacto dos programas de tranferência de renda (CTs) nos desfechos ao nascer, incluindo peso ao nascer, baixo peso ao nascer e prematuridade, e crescimento físico infantil, avaliado pelos índices antropométricos de crianças menores de cinco anos. Revisão sistemática realizada nas bases de dados PubMed/Medline, Embase, LILACS, Cochrane Library, Scopus e Web of Science. Foram incluídos estudos quantitativos observacionais, experimentais e quasi-experimentais, com um total de 11 estudos na revisão. A maioria (81,8%) foi realizada em países de baixa e média rendas. Também na modalidade CT condicionais (63,6%). Quatro eram ensaios clínicos, e sete observacionais. Os CT condicionais estiveram associados a uma redução nos índices de altura-para-idade (-0,14; IC95% -0,27, -0,02); (OR 0,85; IC95% 0,77-0,94); (OR = 0,44; IC95% 0,19-0,98), redução significativa na chance de baixo peso-para-idade (OR = 0,16; IC95% -0,11-0,43), baixo peso-para-altura (OR = -0,68; IC95% -1,14, -0,21), e redução de peso para idade (OR = 0,27; IC95% 0,10; 0,71). CTs não condicionais foram associados à redução do baixo peso as nascer (RR = 0,71; IC95% 0,63-0,81; p < 0,0001), e de prematuros (RR = 0,76; IC95% 0,69-0,84; p < 0,0001). Os CTs condicionais podem influenciar positivamente os desfechos ao nascer e o crescimento infantil. (CTs prematuridade infantil anos PubMedMedline PubMed Medline PubMed/Medline Embase LILACS Library Science observacionais quasiexperimentais, quasiexperimentais quasi experimentais, quasi-experimentais 1 revisão 81,8% 818 81 8 (81,8% rendas 63,6%. 636 63,6% . 63 6 (63,6%) clínicos alturaparaidade altura 0,14 014 0 14 (-0,14 IC95 IC 0,27, 027 27 -0,27 0,02 002 02 -0,02) OR 0,85 085 85 0,770,94 077094 0,77 0,94 77 94 0,77-0,94) 0,44 044 44 0,190,98, 019098 0,19 0,98 , 19 98 0,19-0,98) pesoparaidade 0,16 016 16 0,110,43, 011043 0,11 0,43 43 -0,11-0,43) pesoparaaltura 0,68 068 68 -0,68 1,14, 114 -1,14 0,21, 021 0,21 21 -0,21) 0,27 0,10 010 10 0,71. 071 0,71 71 0,71) RR 0,630,81 063081 0,63 0,81 0,63-0,81 0,0001, 00001 0,0001 0001 0,0001) 0,76 076 76 0,690,84 069084 0,69 0,84 69 84 0,69-0,84 0,0001. 81,8 (81,8 63,6 (63,6% 0,1 01 (-0,1 IC9 2 -0,2 0,0 00 -0,02 0,8 08 770 0,770,9 07709 077 0,7 094 0,9 7 9 0,77-0,94 0,4 04 4 190 0,190,98 01909 019 098 0,19-0,98 110 0,110,43 01104 011 043 -0,11-0,43 0,6 06 -0,6 1,14 -1,1 0,2 -0,21 07 630 0,630,8 06308 063 081 0,63-0,8 0000 0,000 000 690 0,690,8 06908 069 084 0,69-0,8 81, (81, 63, (63,6 0, (-0, -0, -0,0 0,770, 0770 09 0,77-0,9 0,190,9 0190 0,19-0,9 0,110,4 0110 -0,11-0,4 1,1 -1, 0,630, 0630 0,63-0, 0,00 0,690, 0690 0,69-0, (81 (63, (-0 -0 0,770 0,77-0, 0,190, 0,19-0, 0,110, -0,11-0, 1, -1 0,630 0,63-0 0,690 0,69-0 (8 (63 (- - 0,77-0 0,190 0,19-0 0,110 -0,11-0 0,63- 0,69- ( (6 0,77- 0,19- -0,11- -0,11 -0,1

Abstract To investigate the impact of cash transfer (CTs) on birth outcomes, including birth weight, low birth weight and prematurity, as well as child physical growth were included, as assessed by anthropometric indices in children under five years of age. Searching was performed using the PubMed/Medline, Embase, LILACS, Cochrane Library, Scopus and Web of Science databases. Quantitative observational, experimental and quasi-experimental. Eleven studies were included in the review. The majority (81.8%) were carried out in low-and middle-income countries and most involved conditional CTs (63.6%). Four were clinical trials and seven were observational studies. Conditional CTs were found to be associated with a reduction in height-for-age (-0.14; 95%CI -0.27, -0.02); (OR 0.85; 95%CI 0.77-0.94); (OR = 0.44; 95%CI 0.19-0.98), a significantly reduced chance of low weight-for-age (OR = 0.16; 95%CI -0.11-0.43), low weight-for-height (OR = -0.68; 95%CI -1.14, -0.21), and low weight-for-age (OR = 0.27; 95%CI 0.10; 0.71). Unconditional CTs were associated with reduced birth weight (RR = 0.71; 95%CI 0.63-0.81; p < 0.0001) and preterm births (RR = 0.76; 95%CI 0.69-0.84; p < 0.0001). Conditional CTs can positively influence birth outcomes and child growth. (CTs prematurity age PubMedMedline PubMed Medline PubMed/Medline Embase LILACS Library databases quasiexperimental. quasiexperimental quasi experimental. quasi-experimental review 81.8% 818 81 8 (81.8% lowand middleincome middle income 63.6%. 636 63.6% . 63 6 (63.6%) heightforage height for 0.14 014 0 14 (-0.14 95CI CI 95 0.27, 027 27 -0.27 0.02 002 02 -0.02) OR 0.85 085 85 0.770.94 077094 0.77 0.94 77 94 0.77-0.94) 0.44 044 44 0.190.98, 019098 0.19 0.98 , 19 98 0.19-0.98) weightforage 0.16 016 16 0.110.43, 011043 0.11 0.43 11 43 -0.11-0.43) weightforheight 0.68 068 68 -0.68 1.14, 114 1 -1.14 0.21, 021 0.21 21 -0.21) 0.27 0.10 010 10 0.71. 071 0.71 71 0.71) RR 0.630.81 063081 0.63 0.81 0.63-0.81 0.0001 00001 0001 0.76 076 76 0.690.84 069084 0.69 0.84 69 84 0.69-0.84 0.0001. 81.8 (81.8 63.6 (63.6% 0.1 01 (-0.1 9 2 -0.2 0.0 00 -0.02 0.8 08 770 0.770.9 07709 077 0.7 094 0.9 7 0.77-0.94 0.4 04 4 190 0.190.98 01909 019 098 0.19-0.98 110 0.110.43 01104 011 043 -0.11-0.43 0.6 06 -0.6 1.14 -1.1 0.2 -0.21 07 630 0.630.8 06308 063 081 0.63-0.8 0.000 0000 000 690 0.690.8 06908 069 084 0.69-0.8 81. (81. 63. (63.6 0. (-0. -0. -0.0 0.770. 0770 09 0.77-0.9 0.190.9 0190 0.19-0.9 0.110.4 0110 -0.11-0.4 1.1 -1. 0.630. 0630 0.63-0. 0.00 0.690. 0690 0.69-0. (81 (63. (-0 -0 0.770 0.77-0. 0.190. 0.19-0. 0.110. -0.11-0. 1. -1 0.630 0.63-0 0.690 0.69-0 (8 (63 (- - 0.77-0 0.190 0.19-0 0.110 -0.11-0 0.63- 0.69- ( (6 0.77- 0.19- -0.11- -0.11 -0.1

Resumo Fundamento A Insuficiência Cardíaca é um importante problema de saúde pública, que leva à alta carga de sintomas físicos e psicológicos, apesar da terapia otimizada. Objetivo Avaliar primariamente o impacto de um Programa de Redução de Estresse, Meditação e Atenção plena na redução do estresse de pacientes com Insuficiência Cardíaca. Métodos Ensaio clínico randomizado e controlado que avaliou o impacto de um programa de redução de estresse comparado ao atendimento multidisciplinar convencional, em dois centros especializados no Brasil. O período de coleta de dados ocorreu entre abril e outubro de 2019. Um total de 38 pacientes foram alocados nos grupos de intervenção ou controle. A intervenção aconteceu ao longo de 8 semanas. O protocolo consistiu na avaliação das escalas de estresse percebido, depressão, qualidade de vida, ansiedade, atenção plena, qualidade do sono, teste de 6 minutos de caminhada e biomarcadores por um grupo cego, considerando um p-valor <0,05 como estatisticamente significativo. Resultados A intervenção resultou em redução significativa no estresse percebido de 22,8 ± 4,3 para 14,3 ± 3,8 pontos na escala de estresse percebido no grupo de intervenção vs. 23,9 ± 4,3 para 25,8 ± 5,4 no grupo controle (p-valor<0,001). Foi observada melhora significativa na qualidade de vida (p-valor=0,013), atenção plena (p-valor=0,041), qualidade do sono (p-valor<0,001) e no teste de 6 minutos de caminhada (p-valor=0,004) no grupo sob intervenção comparado com o controle. Conclusão O Programa de Redução de Estresse, Meditação e Atenção plena reduziu efetivamente o estresse percebido e melhorou desfechos clínicos em pacientes com Insuficiência Cardíaca. pública psicológicos otimizada Estresse convencional Brasil 2019 3 semanas depressão ansiedade cego pvalor p valor 005 0 05 <0,0 significativo 228 22 22, 43 4 4, 143 14 14, 3, vs 239 23 9 23, 258 25 25, 54 5 5, pvalor<0,001. pvalor0001 valor<0,001 . 001 pvalor=0,013, pvalor0013 valor=0,013 , 013 (p-valor=0,013) pvalor=0,041, pvalor0041 valor=0,041 041 (p-valor=0,041) pvalor<0,001 (p-valor<0,001 pvalor=0,004 pvalor0004 valor=0,004 004 (p-valor=0,004 201 00 <0, 2 1 pvalor000 valor0001 valor<0,00 pvalor=0,013 pvalor001 valor0013 valor=0,01 01 (p-valor=0,013 pvalor=0,041 pvalor004 valor0041 valor=0,04 04 (p-valor=0,041 pvalor<0,00 (p-valor<0,00 pvalor=0,00 valor0004 valor=0,00 (p-valor=0,00 20 <0 pvalor00 valor000 valor<0,0 pvalor=0,01 valor001 valor=0,0 (p-valor=0,01 pvalor=0,04 valor004 (p-valor=0,04 pvalor<0,0 (p-valor<0,0 pvalor=0,0 (p-valor=0,0 < pvalor0 valor00 valor<0, valor=0, pvalor<0, (p-valor<0, pvalor=0, (p-valor=0, valor0 valor<0 valor=0 pvalor<0 (p-valor<0 pvalor=0 (p-valor=0 valor< valor= pvalor< (p-valor< pvalor= (p-valor= (p-valor

Abstract Background Heart Failure is a significant public health problem leading to a high burden of physical and psychological symptoms despite optimized therapy. Objective To evaluate primarily the impact of a Stress Reduction, Meditation, and Mindfulness Program on stress reduction of patients with Heart Failure. Methods A randomized and controlled clinical trial assessed the effect of a stress reduction program compared to conventional multidisciplinary care in two specialized centers in Brazil. The data collection period took place between April and October 2019. Thirty-eight patients were included and allocated to the intervention or control groups. The intervention took place over 8 weeks. The protocol assessed the scales of perceived stress, depression, quality of life, anxiety, mindfulness, quality of sleep, a 6-minute walk test, and biomarkers analyzed by a blinded team, considering a p-value <0.05 statistically significant. Results The intervention resulted in a significant reduction in perceived stress from 22.8 ± 4.3 to 14.3 ± 3.8 points in the perceived stress scale-14 items in the intervention group vs. 23.9 ± 4.3 to 25.8 ± 5.4 in the control group (p-value<0.001). A significant improvement in quality of life (p-value=0.013), mindfulness (p-value=0.041), quality of sleep (p-value<0.001), and the 6-minute walk test (p-value=0.004) was also observed in the group under intervention in comparison with the control. Conclusion The Stress Reduction, Meditation, and Mindfulness Program effectively reduced perceived stress and improved clinical outcomes in patients with chronic Heart Failure. therapy Reduction Meditation Brazil 2019 Thirtyeight Thirty eight groups weeks depression anxiety 6minute minute 6 team pvalue p value 005 0 05 <0.0 228 22 22. 43 4 3 4. 143 14 14. 38 3. scale14 scale scale-1 vs 239 23 9 23. 258 25 25. 54 5 5. pvalue<0.001. pvalue0001 value<0.001 . 001 (p-value<0.001) pvalue=0.013, pvalue0013 value=0.013 , 013 (p-value=0.013) pvalue=0.041, pvalue0041 value=0.041 041 (p-value=0.041) pvalue<0.001, pvalue=0.004 pvalue0004 value=0.004 004 (p-value=0.004 201 00 <0. 2 1 scale1 scale- pvalue<0.001 pvalue000 value0001 value<0.00 (p-value<0.001 pvalue=0.013 pvalue001 value0013 value=0.01 01 (p-value=0.013 pvalue=0.041 pvalue004 value0041 value=0.04 04 (p-value=0.041 pvalue=0.00 value0004 value=0.00 (p-value=0.00 20 <0 pvalue<0.00 pvalue00 value000 value<0.0 (p-value<0.00 pvalue=0.01 value001 value=0.0 (p-value=0.01 pvalue=0.04 value004 (p-value=0.04 pvalue=0.0 (p-value=0.0 < pvalue<0.0 pvalue0 value00 value<0. (p-value<0.0 value=0. pvalue=0. (p-value=0. pvalue<0. value0 value<0 (p-value<0. value=0 pvalue=0 (p-value=0 pvalue<0 value< (p-value<0 value= pvalue= (p-value= pvalue< (p-value< (p-value

Aim The aim of the present study is to assess the perception of undergraduate students on the impact of the COVID-19 pandemic on Brazilian dental education. Methods This cross-sectional study was conducted using an online questionnaire hosted in Google Forms platform and publicized on Instagram® and Facebook®. The questionnaire was available between July 8-27, 2020. Absolute and relative frequencies were obtained for variables of interest using Pearson’s chi-squared and considering 95% confidence intervals. Prevalence of learning resource variables according to self-reported skin color, educational institution, and Brazilian region were presented using equiplots. Results A total of 1,050 undergraduate dental students answered the questionnaire. Most students reported being in full-distance learning mode. Among the undergraduate students, 65.4% reported perceiving a very high impact in dental education, and 16.6% of students reported not being able to follow distance learning. In addition, 14% reported not having a personal laptop or desktop to study with, with this condition being more prevalent among non-white than white individuals. Conclusion We conclude that Brazilian dental students perceived a high impact of COVID-19 on dental education, as well as one-sixth of the students reported not having adequate resources to continue with distance learning. It is important that different policies are developed at the institutional and governmental levels to reduce the impact of the pandemic on dental education. COVID19 COVID 19 COVID-1 education crosssectional cross sectional Instagram Facebook Facebook® 827, 827 8 27, 27 8-27 2020 Pearsons Pearson s chisquared chi squared 95 intervals selfreported self color institution equiplots 1050 1 050 1,05 fulldistance full mode 654 65 4 65.4 166 16 6 16.6 addition 14 nonwhite non individuals onesixth one sixth COVID1 COVID- 82 2 8-2 202 9 105 05 1,0 65. 16. 8- 20 10 0 1,

Resumo Investigar o impacto dos programas de tranferência de renda (CTs) nos desfechos ao nascer, incluindo peso ao nascer, baixo peso ao nascer e prematuridade, e crescimento físico infantil, avaliado pelos índices antropométricos de crianças menores de cinco anos. Revisão sistemática realizada nas bases de dados PubMed/Medline, Embase, LILACS, Cochrane Library, Scopus e Web of Science. Foram incluídos estudos quantitativos observacionais, experimentais e quasi-experimentais, com um total de 11 estudos na revisão. A maioria (81,8%) foi realizada em países de baixa e média rendas. Também na modalidade CT condicionais (63,6%). Quatro eram ensaios clínicos, e sete observacionais. Os CT condicionais estiveram associados a uma redução nos índices de altura-para-idade (-0,14; IC95% -0,27, -0,02); (OR 0,85; IC95% 0,77-0,94); (OR = 0,44; IC95% 0,19-0,98), redução significativa na chance de baixo peso-para-idade (OR = 0,16; IC95% -0,11-0,43), baixo peso-para-altura (OR = -0,68; IC95% -1,14, -0,21), e redução de peso para idade (OR = 0,27; IC95% 0,10; 0,71). CTs não condicionais foram associados à redução do baixo peso as nascer (RR = 0,71; IC95% 0,63-0,81; p < 0,0001), e de prematuros (RR = 0,76; IC95% 0,69-0,84; p < 0,0001). Os CTs condicionais podem influenciar positivamente os desfechos ao nascer e o crescimento infantil.

Abstract To investigate the impact of cash transfer (CTs) on birth outcomes, including birth weight, low birth weight and prematurity, as well as child physical growth were included, as assessed by anthropometric indices in children under five years of age. Searching was performed using the PubMed/Medline, Embase, LILACS, Cochrane Library, Scopus and Web of Science databases. Quantitative observational, experimental and quasi-experimental. Eleven studies were included in the review. The majority (81.8%) were carried out in low-and middle-income countries and most involved conditional CTs (63.6%). Four were clinical trials and seven were observational studies. Conditional CTs were found to be associated with a reduction in height-for-age (-0.14; 95%CI -0.27, -0.02); (OR 0.85; 95%CI 0.77-0.94); (OR = 0.44; 95%CI 0.19-0.98), a significantly reduced chance of low weight-for-age (OR = 0.16; 95%CI -0.11-0.43), low weight-for-height (OR = -0.68; 95%CI -1.14, -0.21), and low weight-for-age (OR = 0.27; 95%CI 0.10; 0.71). Unconditional CTs were associated with reduced birth weight (RR = 0.71; 95%CI 0.63-0.81; p < 0.0001) and preterm births (RR = 0.76; 95%CI 0.69-0.84; p < 0.0001). Conditional CTs can positively influence birth outcomes and child growth.

Resumo Objetivo analisar a percepção dos participantes sobre os eventos online promovidos durante o primeiro ano da pandemia da Covid-19 pela Liga de Cuidados à Saúde das Mulheres (LCSM). Métodos estudo transversal, descritivo, de abordagem quantitativa e qualitativa, desenvolvido de forma online com 90 participantes em dez eventos sobre a temática relativa à saúde da mulher, promovidos pela LCSM no ano de 2020. Os dados foram coletados por um formulário semi-estruturado online no período de julho a novembro de 2021. Para a análise de dados, utilizou-se o IBM SPSS, por meio de estatística descritiva das variáveis qualitativas e para a análise dos dados qualitativos utilizou-se a análise temática. Resultados 98,89% dos participantes responderam que os eventos da LCSM no formato online influenciaram de forma positiva na vida acadêmica, profissional ou pessoal. A análise das respostas permitiu a identificação de três categorias: sentimento de “aproximação” à Universidade, descrição das influências positivas, e conhecimentos para além da sala de aula. Conclusão e implicações para a prática Os dados do presente estudo permitem inferir o importante e necessário papel da tecnologia da informação e das ligas acadêmicas na construção do conhecimento e no aprofundamento das reflexões e do debate sobre os cuidados à saúde das mulheres. Covid19 Covid 19 Covid-1 LCSM. . (LCSM) transversal descritivo qualitativa 9 mulher 2020 semiestruturado semi estruturado 2021 utilizouse utilizou se SPSS 9889 98 89 98,89 acadêmica pessoal categorias aproximação “aproximação Universidade positivas aula mulheres Covid1 1 Covid- (LCSM 202 988 8 98,8 20 98, 2

Abstract Objective to analyze the participants' perception of the online events promoted during the first year of the Covid-19 pandemic by the Women's Health Care League (LCSM). Methods cross-sectional, descriptive study, with a quantitative and qualitative approach, developed online with 90 participants in ten events on the theme of women's health, promoted by LCSM in 2020. Data were collected using a semi-structured online form from July to November 2021. For data analysis, IBM SPSS was used, through descriptive statistics of qualitative variables and for the analysis of qualitative data, thematic analysis was used. Results 98,89% of the participants answered that the LCSM events in online format had a positive influence on their academic, professional or personal life. The analysis of the responses allowed the identification of three categories: feeling of “closeness” to the University, description of positive influences, and knowledge beyond the classroom. Conclusion and implications for practice The data from this study allow us to infer the important and necessary role of information technology and academic leagues in the construction of knowledge and in the deepening of reflections and debate on women's health care. Covid19 Covid 19 Covid-1 Womens Women s LCSM. . (LCSM) crosssectional, crosssectional cross sectional, sectional cross-sectional approach 9 womens women 2020 semistructured semi structured 2021 used 9889 98 89 98,89 life categories closeness “closeness University influences classroom care Covid1 1 Covid- (LCSM 202 988 8 98,8 20 98, 2

Resumen Objetivo analizar la percepción de los participantes de los eventos online promovidos durante el primer año de la pandemia del Covid-19 por la Liga para el Cuidado de la Salud de la Mujer (LCSM). Método estudio transversal, descriptivo, con abordaje cuantitativo y cualitativo, desarrollado online con 90 participantes en diez eventos sobre el tema salud de la mujer, promovidos por la LCSM en 2020. Los datos fueron recogidos a través de un formulario semi-estructurado en línea de julio a noviembre de 2021. Para el análisis de datos se utilizó IBM SPSS, a través de estadística descriptiva de variables cualitativas y para el análisis de datos cualitativos se utilizó análisis temático. Resultados El 98,89% de los participantes respondieron que los eventos LCSM en formato online influyeron positivamente en su vida académica, profesional o personal. El análisis de las respuestas permitió identificar tres categorías: sentirse “más cerca” de la Universidad, descripción de influencias positivas y conocimiento más allá del aula. Conclusión e implicaciones para la práctica Los datos del presente estudio permiten inferir el importante y necesario papel de las tecnologías de la información y de las ligas académicas en la construcción del conocimiento y en la profundización de la reflexión y el debate sobre el cuidado de la salud de las mujeres. Covid19 Covid 19 Covid-1 LCSM. . (LCSM) transversal descriptivo cualitativo 9 mujer 2020 semiestructurado semi estructurado 2021 SPSS temático 9889 98 89 98,89 académica personal categorías cerca Universidad aula mujeres Covid1 1 Covid- (LCSM 202 988 8 98,8 20 98, 2

Resumo Objetivo analisar os desafios para a relação terapêutica na perspectiva do cuidado centrado na pessoa. Método pesquisa social modalidade estratégica, de abordagem qualitativa, realizada com 17 profissionais de dois Centros de Atenção Psicossocial (CAPS) da região central do Brasil. Os dados foram coletados por meio de entrevistas individuais online com roteiro semiestruturado e anotações em diário de campo. Foram organizados com o auxílio do software ATLAS.ti, submetidos à análise temática. Resultados emergiram quatro categorias sobre os desafios para a relação terapêutica que abordaram aspectos relacionados às equipes de saúde, aos usuários, à família e aos processos de trabalho dos serviços estudados. Conclusão e implicações para a prática foram identificados desafios que interferem no estabelecimento da relação terapêutica entre os profissionais dos CAPS, usuários e seus familiares que inviabilizam a concretização do modelo de cuidado centrado na pessoa. Relações interpessoais frágeis se configuram empecilhos para a construção de vínculo, o que demanda processos de educação continuada e permanente para a transformação dessa realidade. pessoa estratégica qualitativa 1 CAPS (CAPS Brasil campo ATLASti ATLAS ti ATLAS.ti temática saúde estudados vínculo realidade

Abstract Objective to analyze the challenges for the therapeutic relationship from the perspective of person-centered care. Method strategic social research, with a qualitative approach, carried out with 17 professionals from two Psychosocial Care Centers (CAPS) in central Brazil. Data were collected through individual online interviews with a semi-structured script and notes in a field diary. They were organized with the help of the ATLAS.ti software, submitted to thematic analysis. Results four categories emerged on the challenges for the therapeutic relationship that addressed aspects related to health teams, users, family and work processes of the services studied. Conclusion and implications for practice challenges were identified that interfere with the establishment of the therapeutic relationship between CAPS professionals, users and their families that make it impossible to implement the person-centered care model. Fragile interpersonal relationships constitute obstacles to bond building, which demands continuing and permanent education processes to transform this reality. personcentered person centered research approach 1 (CAPS Brazil semistructured semi structured diary ATLASti ATLAS ti software analysis teams studied model building reality

Resumen Objetivo analizar los desafíos para la relación terapéutica desde la perspectiva del cuidado centrado en la persona. Método investigación social estratégica, con abordaje cualitativa, realizada con 17 profesionales de dos Centros de Atención Psicosocial (CAPS) del centro de Brasil. Los datos fueron recolectados a través de entrevistas individuales en línea con un guión semiestructurado y notas en un diario de campo. Fueron organizados con la ayuda del software ATLAS.ti, sometidos a análisis temático. Resultados surgieron cuatro categorías sobre los desafíos para la relación terapéutica que abordaron aspectos relacionados con los equipos de salud, los usuarios, la familia y los procesos de trabajo de los servicios estudiados. Conclusión e implicaciones para la práctica se identificaron desafíos que interfieren en el establecimiento de la relación terapéutica entre los profesionales del CAPS, los usuarios y sus familias que imposibilitan la implementación del modelo de atención centrado en la persona. Las relaciones interpersonales frágiles constituyen obstáculos para la construcción de vínculos, lo que exige procesos de educación continua y permanente para transformar esta realidad. persona estratégica cualitativa 1 CAPS (CAPS Brasil campo ATLASti ATLAS ti ATLAS.ti temático salud estudiados vínculos realidad

Objective: To analyze the associated factors of reductions for dental visits performed in Primary Health Care (PHC) in Brazil during COVID-19 pandemic. Methods: Crosssectional study with PHC dentists. The outcome was a reduction in dental care appointments and that the exposure variables included sociodemographic factors, aspects about personal protective clothing and equipment (PPE) and measures adopted by the Basic Health Unit (UBS) in Brazil after the appearance of COVID. Poisson regression was performed, used to determine the prevalence ratio and 95% confidence interval. Results: Reduction in visits above 50% after the onset of the pandemic was reported by 62.6% of 958 participating. Biosafety protocols (PR=1.04 – 95%CI 1.01;1.07), PPE suggested by the protocols (PR=0.94 – 95%CI 0.89;0.99), and telescreening (PR=0.90 – 95%CI 0.85;0.96) were factors associated with this reduction. Conclusion: The availability of the new PPE and the implementation of telescreening at UBS seem to have minimized the reduction in dental care after the onset of the pandemic

Objetivo: Analizar factores asociados a la reducción de consultas odontológicas en Atención Primaria de Salud (APS) en Brasil durante COVID-19. Métodos: Estudio transversal con dentistas de APS. El hecho investigado fue reducción de consultas odontológicas y las variables de exposición incluyeron factores sociodemográficos, aspectos de los equipos de protección personal (EPI) y las medidas adoptadas por la Unidad Básica de Salud (UBS) tras la aparición del COVID. Regresión de Poisson utilizada para determinar la razón de prevalencia y el intervalo de confianza del 95%. Resultados: El 62,6% de los 958 participantes informó una reducción en la asistencia superior al 50% después del inicio de la pandemia. La adopción de protocolos (RP=1,04 – IC95% 1,01;1,07), disponibilidad de EPI recomendado por los nuevos protocolos (RP=0,94 – IC95% 0,89;0,99) y la adopción de televaluación (RP=0,90 – IC95% 0,85;0,96) fueron factores que se asoció con esta reducción. Conclusión: La disponibilidad del nuevo EPP y la implementación de la teleprotección en UBS parecen haber minimizado la reducción en la atención dental después del inicio de la pandemia.

Objetivo: Analisar fatores associados à redução de atendimentos odontológicos na Atenção Primária à Saúde, durante pandemia de COVID-19 no Brasil. Métodos: Estudo transversal, com cirurgiões-dentistas das unidades básicas de saúde (UBS). O desfecho foi a redução dos atendimentos odontológicos, e as variáveis de exposição, dados sociodemográficos, disponibilidade de equipamentos de proteção individual (EPIs) e medidas adotadas pela UBS na pandemia. Realizou-se regressão de Poisson para determinar razão de prevalências e intervalo de confiança de 95%. Resultados: A redução de atendimentos acima de 50% após o início da pandemia foi relatada por 62,6% dos 958 participantes. Adoção de protocolos de biossegurança (RP=1,04 – IC95% 1,01;1,07), disponibilidade de EPI preconizados por novos protocolos (RP=0,94 – IC95% 0,89;0,99) e adoção da teletriagem (RP=0,90 – IC95% 0,85;0,96) estiveram associados à redução. Conclusão: A disponibilização dos novos EPIs e a implementação da teletriagem nas UBS parecem ter minimizado a redução dos atendimentos odontológicos após o início da pandemia.