RESUMO As espécies do gênero Capsicum, principalmente pimentão, possuem grande relevância econômica e são amplamente consumidas em todo o mundo. A aplicação de dejetos animais como fertilizante orgânico é uma técnica simples e barata de distribuição de nutrientes ao solo. O esterco bovino em associação com substâncias húmicas pode estimular o metabolismo das plantas, resultando no aumento da absorção e assimilação de nutrientes. Portanto, o objetivo neste estudo foi avaliar doses de esterco bovino associado a substâncias húmicas para estimular o metabolismo vegetal, a morfofisiologia e a nutrição em pimentões. O delineamento utilizado foi em blocos casualizados, distribuídos em arranjo fatorial 4 x 3, referente a quatro doses de esterco bovino (8, 18, 28 e 38 t ha-1) e três doses de substâncias húmicas (0, 8 e 12 kg ha-1), com quatro repetições. Substâncias húmicas (12 kg ha-1) estimularam as trocas gasosas, aumentando a fotossíntese líquida (34,2%), a condutância estomática (12,7%), a eficiência instantânea do uso da água (15,87%), a eficiência instantânea de carboxilação (37,37%) e a eficiência efetiva da absorção conversão de energia (23,53%). O esterco bovino supriu adequadamente as necessidades nutricionais da cultura, enquanto as substâncias húmicas aumentaram o número e a espessura dos pelos radiculares do pimentão. A combinação de manejo mais eficaz para aumentar a atividade fotossintética em pimentões é 38 t ha-1 de esterco combinado com 8 kg ha-1 de substâncias húmicas. As substâncias húmicas estimularam respostas morfofisiológicas positivas no cultivo de pimentão orgânico, o que resultou no aumento da produção. Capsicum mundo solo plantas Portanto vegetal casualizados 3 8, (8 18 2 ha1 ha 1 0, 0 (0 ha1, , repetições (1 gasosas 34,2%, 342 34,2% 34 (34,2%) 12,7%, 127 12,7% 7 (12,7%) 15,87%, 1587 15,87% 15 87 (15,87%) 37,37% 3737 37 (37,37% 23,53%. 2353 23,53% . 23 53 (23,53%) cultura ha- produção ( 34,2 (34,2% 12,7 (12,7% 158 15,87 (15,87% 37,37 373 (37,37 235 23,53 5 (23,53% 34, (34,2 12, (12,7 15,8 (15,87 37,3 (37,3 23,5 (23,53 (34, (12, 15, (15,8 37, (37, 23, (23,5 (34 (15, (37 (23, (3 (15 (23 (2

ABSTRACT Species of the genus Capsicum, especially peppers, are economically important and widely consumed worldwide. The application of animal waste as organic fertilizer is a simple and cost-effective technique for applying nutrients to the soil. Combining cattle manure with humic substances can stimulate plant metabolism, resulting in increased nutrient absorption and assimilation. Therefore, the objective in this study was to evaluate doses of cattle manure combined with humic substances for stimulating plant metabolism and morphophysiological and nutritional processes in pepper plants. A randomized block design with four replicates was used, in a 4×3 factorial arrangement consisting of four cattle manure doses (8, 18, 28, and 38 Mg ha-1) and three humic substance doses (0, 8, and 12 kg ha-1). Humic substances (12 kg ha-1) enhanced gas exchange, increasing net photosynthesis (34.2%), stomatal conductance (12.7%), instantaneous water use efficiency (15.87%), instantaneous carboxylation efficiency (37.37%), and absorbed energy conversion efficiency (23.53%). Cattle manure adequately met the crop’s nutritional requirements, while humic substances increased the number and thickness of plant root hairs. The most effective combination to increase photosynthetic activity in pepper plants was 38 Mg ha-1 of cattle manure combined with 8 kg ha-1 of humic substances. Humic substances stimulated positive morphophysiological responses in organic pepper crops, which resulted in increased production. Capsicum peppers worldwide costeffective cost soil assimilation Therefore used 43 4 3 4× (8 18 28 ha1 ha 1 0, 0 (0 ha1. . (1 exchange 34.2%, 342 34.2% , 34 2 (34.2%) 12.7%, 127 12.7% 7 (12.7%) 15.87%, 1587 15.87% 15 87 (15.87%) 37.37%, 3737 37.37% 37 (37.37%) 23.53%. 2353 23.53% 23 53 (23.53%) crops crop s requirements hairs ha- production ( 34.2 (34.2% 12.7 (12.7% 158 15.87 (15.87% 373 37.37 (37.37% 235 23.53 5 (23.53% 34. (34.2 12. (12.7 15.8 (15.87 37.3 (37.37 23.5 (23.53 (34. (12. 15. (15.8 37. (37.3 23. (23.5 (34 (15. (37. (23. (3 (15 (37 (23 (2

RESUMO O estresse salino limita o crescimento e a fisiologia da capuchinha (Tropaeolum majus), devido a distúrbios bioquímicos, fisiológicos e anatômicos. A aplicação de ácido salicílico é uma alternativa para mitigar os efeitos prejudiciais do estresse salino, no entanto, em capuchinha os estudos são escassos. Assim, objetivou-se avaliar os efeitos da aplicação de ácido salicílico via foliar em capuchinha cultivada sob estresse salino. O experimento foi realizado em delineamento inteiramente casualizado, em esquema fatorial 3 x 3, referente a 0 (sem estresse) 50 (estresse salino moderado) e 100 (estresse salino severo) mM de NaCl e aplicação de 0, 0,5 e 1 mM de ácido salicílico, com seis repetições. O crescimento (altura de planta, diâmetro do caule e número de folhas), trocas gasosas (condutância estomática, fotossíntese, transpiração, concentração interna de CO2, eficiência intrínseca do uso da água, eficiência instantânea do uso da água e eficiência intrínseca de carboxilação) e os índices de clorofila e fluorescência da clorofila a foram avaliados. O estresse salino afetou as variáveis analisadas neste estudo. A aplicação de ácido salicílico teve um efeito positivo na mitigação dos efeitos do estresse salino severo, resultando em um aumento significativo no número de folhas, sendo a dose mais eficaz a concentração de 1 mM, levando ainda, a melhorias notáveis na eficiência no uso da água e na eficiência fotoquímica. No entanto, as demais combinações de salinidade e ácido salicílico reduziram o crescimento e as trocas gasosas nas plantas de capuchinha. Tropaeolum majus, majus , majus) bioquímicos anatômicos entanto escassos Assim objetivouse objetivou se casualizado sem 5 moderado 10 severo 05 repetições altura planta folhas folhas) condutância estomática fotossíntese transpiração CO2 CO carboxilação avaliados estudo ainda fotoquímica

ABSTRACT Salt stress hampers the growth and physiology of nasturtium (Tropaeolum majus), due to biochemical, physiological, and anatomical disruptions. The application of salicylic acid stands as an alternative to alleviate the detrimental effects of salt stress, but studies on nasturtium are scarce. Thus, the aim of present study was to assess the effects of foliar application of salicylic acid on nasturtium cultivated under salt stress. The experiment followed a completely randomized design in a 3 x 3 factorial scheme, with 0 (no stress), 50 (moderate salt stress), and 100 (severe salt stress) mM of NaCl, and application of 0, 0.5, and 1 mM of salicylic acid, each with six replications. Growth (plant height, stem diameter, and number of leaves), gas exchange (stomatal conductance, photosynthesis, transpiration, internal CO2 concentration, intrinsic water use efficiency, instantaneous water use efficiency, and intrinsic carboxylation efficiency), as well as chlorophyll indices and chlorophyll a fluorescence were evaluated. Salt stress affected the variables analyzed in this study. The application of salicylic acid had a positive effect on mitigating the effects of severe salt stress, resulting in a significant increase in the number of leaves. The most effective dose was 1 mM, also leading to notable improvements in water use efficiency and photochemical efficiency. However, other combinations of salinity and salicylic acid reduced growth and gas exchange in nasturtium plants. Tropaeolum majus, majus , majus) biochemical physiological disruptions scarce Thus scheme no 5 moderate 10 NaCl 05 0.5 replications plant height diameter leaves, leaves leaves) stomatal conductance photosynthesis transpiration CO concentration efficiency) evaluated However plants 0.

RESUMO Objetivo Avaliar a prevalência de consumo de alimentos ultraprocessados e fatores associados em crianças matriculadas na rede pública do município de Barbacena, Minas Gerais, Brasil. Métodos Trata-se de um estudo transversal realizado com escolares de 7 a 9 anos de ambos os sexos, matriculados na rede pública estadual de ensino. O consumo alimentar foi avaliado utilizando o Questionário Alimentar do Dia Anterior e o nível de atividade física pelo Questionário de Atividade Física do Dia Anterior. Os alimentos listados foram classificados segundo a extensão e propósito do processamento industrial, conforme proposto pela classificação NOVA. Na análise estatística foram utilizados os testes χ2 de Pearson, Exato de Fisher, χ2 com correção de Yates e regressão de Poisson, estimando-se a razão de prevalência bruta e ajustada, com intervalos de confiança de 95%. Resultados A prevalência de consumo de alimentos ultraprocessados foi de 69,6%. Após análises ajustadas, o consumo de alimentos ultraprocessados foi associado à omissão do café da manhã, lanche da tarde e ceia, baixo nível de atividade física e ao consumo de alimentos de risco. Por outro lado, o consumo de alimentos in natura ou minimamente processados foi associado à maior idade, consumo de almoço, lanche da tarde, jantar e alimentos protetivos. Conclusões Verificamos uma alta prevalência no consumo de alimentos ultraprocessados, associada a hábitos alimentares não saudáveis, em crianças escolares. Isso destaca a necessidade de ações de educação alimentar e nutricional, favorecendo o consumo alimentar saudável na infância. Barbacena Gerais Brasil Tratase Trata se sexos ensino industrial NOVA χ Pearson Fisher Poisson estimandose estimando ajustada 95 95% 696 69 6 69,6% ajustadas manhã ceia risco lado idade almoço protetivos saudáveis nutricional infância 69,6 69,

Abstract Objective: To evaluate the prevalence of ultra-processed food consumption and associated factors among children enrolled in the public school system of the city of Barbacena, Minas Gerais, Brazil. Methods: This is a cross-sectional study conducted with schoolchildren aged 7–9 years, of both sexes, enrolled in state public schools. Food intake was assessed using the Previous Day Food Questionnaire and the level of physical activity by the Previous Day Physical Activity Questionnaire. The listed foods were classified according to the extent and purpose of industrial processing, using the NOVA classification. Pearson’s χ2 test, Fisher’s exact test, χ2 with Yates correction, and Poisson regression were used in the statistical analysis, estimating the crude and adjusted prevalence ratio, with 95% confidence intervals. Results: The prevalence of daily ultra-processed food consumption was 69.6%. After adjusted analyses, the consumption of ultra-processed food was associated with the omission of breakfast, mid-afternoon snack, supper, low physical activity, and consumption of risk foods. On the other hand, consumption of in natura or minimally processed foods was associated with older age, the consumption of lunch, mid-afternoon snack, dinner, and protective foods. Conclusions: There is a high prevalence of ultra-processed foods consumption, associated with unhealthy dietary habits among schoolchildren. This highlights the need for nutritional counseling and educational actions, favoring healthy eating in childhood. Objective ultraprocessed ultra Barbacena Gerais Brazil Methods crosssectional cross sectional 79 7 9 7– years sexes schools processing classification Pearsons Pearson s χ test Fishers Fisher correction analysis ratio 95 intervals Results 696 69 6 69.6% analyses breakfast midafternoon mid afternoon snack supper hand age lunch dinner Conclusions actions childhood 69.6 69.

Abstract The objective of this manuscript was to investigate the influence of different Babassu Mesocarp Flour (BMF) contents (3, 5, 8, and 10% by weight) on the physical and surface properties of the Poly(Lactic Acid) (PLA) matrix. For this purpose, composite films were produced through flat-die extrusion processing. Visual analysis showed that the films were successfully produced by this processing method and exhibited good handling. The physical properties of the films varied as follows: width (16.41‒20.38 cm), thickness (0.14‒0.24 mm), apparent density (0.78‒1.07 g/cm3), and grammage (168.34‒255.31 g/m2). Through optical microscopy, good distribution and dispersion of the particles were observed despite the presence of some agglomerates. The film surface became rough due to the incorporated flour content, which influenced the contact angle result. The combination of PLA/BMF for producing composite films has technological potential, enabling the valorization of an industrial by-product and preserving the environment. BMF (BMF 3, 3 (3 5 8 10 weight PolyLactic Poly Lactic Acid PLA (PLA matrix purpose flatdie flat die handling follows 16.41‒20.38 16412038 16 41 20 38 (16.41‒20.3 cm, cm , cm) 0.14‒0.24 014024 0 14 24 (0.14‒0.2 mm, mm mm) 0.78‒1.07 078107 78 1 07 (0.78‒1.0 g/cm3, gcm3 gcm g/cm3 g cm3 g/cm3) 168.34‒255.31 1683425531 168 34 255 31 (168.34‒255.3 g/m2. gm2 gm g/m2 . m2 m g/m2) microscopy agglomerates content result PLABMF potential byproduct product environment ( 16.41‒20.3 1641203 4 2 (16.41‒20. 0.14‒0.2 01402 (0.14‒0. 0.78‒1.0 07810 7 (0.78‒1. g/cm 168.34‒255.3 168342553 25 (168.34‒255. g/m 16.41‒20. 164120 (16.41‒20 0.14‒0. 0140 (0.14‒0 0.78‒1. 0781 (0.78‒1 168.34‒255. 16834255 (168.34‒255 16.41‒20 16412 (16.41‒2 0.14‒0 014 (0.14‒ 0.78‒1 078 (0.78‒ 168.34‒255 1683425 (168.34‒25 16.41‒2 1641 (16.41‒ 0.14‒ 01 (0.14 0.78‒ (0.78 168.34‒25 168342 (168.34‒2 16.41‒ 164 (16.41 0.14 (0.1 0.78 (0.7 168.34‒2 16834 (168.34‒ 16.41 (16.4 0.1 (0. 0.7 168.34‒ 1683 (168.34 16.4 (16. 0. (0 168.34 (168.3 16. (16 168.3 (168. (1 168. (168

Resumo Introdução A doença pulmonar obstrutiva crônica (DPOC) não apenas restringe o fluxo aéreo, mas também induz mani-festações sistêmicas em indivíduos com a doença. Objetivo Avaliar o efeito de um programa de exercícios aeróbicos aquáticos na força muscular respiratória (FMR), mobilidade torácica, dispneia e capacidade funcional em pacientes com DPOC. Métodos Realizou-se um ensaio clínico randomizado cego com 22 pacientes com DPOC, divi-dindo-os em grupo controle (GC) e grupo treinamento (GT). O GT participou de 24 sessões de um programa de exercícios aeróbicos aquáticos, enquanto o GC participou somente das avaliações. Foram me-didas a pressão respiratória máxima, (PRM) dispneia e capa-cidade funcional. Resultados Ao comparar os valores da PRM (cmH2O) nas condições pré e pós-treinamento, os resultados revelaram melhora significativa no GT [pressão inspiratória má-xima (PImáx): 74,8 ± 15,3 vs. 83,9 ± 17,2; pressão expiratória máxima (PEmáx): 141,5 ± 30,7 vs. 157,6 ± 32,9], enquanto não observou-se diferença para o GC (PImáx: 55,5 ± 21,8; vs. 54,4 ± 18,4; PEmáx: 116,2 ± 40,3 vs. 109,3 ± 38,9). Em relação à mobilidade torácica nas condições pré e pós-treinamento, não foi encontrada diferença significativa para o GC, enquanto para o GT houve um aumento significante no nível axilar (cm) (5,9 ± 1,8 vs. 7,7 ± 1,1). Com relação à capacidade funcional, houve aumento significativo da distância percorrida durante o teste de caminhada de 6 minutos apenas no GT quando comparadas as condições pré e pós-treinamento (462,1 ± 62,9 vs. 538,5 ± 63,7). Por fim, os resultados da dispneia demonstraram que após o período de treinamento houve uma redução importante nas pontuações do Medical Research Council (3,1 ± 0,8 vs. 1,9 ± 0,7) e nas escalas Borg CR-10 (5,2 ± 0,8 vs. 3,7 ± 0,3) apenas para o GT. Conclusão O trei-namento físico aquático promoveu alterações benéficas na força muscular respiratória, mobilidade torácica, capacidade funcional e dispneia em pacientes com DPOC. DPOC (DPOC aéreo manifestações mani festações FMR, FMR , (FMR) Realizouse Realizou se 2 dividindoos divi dindo (GC . (GT) avaliações medidas me didas (PRM capa cidade cmH2O cmHO cmH (cmH2O póstreinamento, póstreinamento pós treinamento, má xima PImáx (PImáx) 748 74 8 74, 153 15 3 15, vs 839 83 9 83, 17,2 172 17 PEmáx (PEmáx) 1415 141 5 141, 307 30 7 30, 1576 157 157, 32,9, 329 32,9 32 32,9] observouse observou (PImáx 555 55 55, 21,8 218 21 544 54 4 54, 18,4 184 18 1162 116 116, 403 40 40, 1093 109 109, 38,9. 389 38,9 38 38,9) cm (cm 5,9 59 (5, 1 1, 77 7, 1,1. 11 1,1 1,1) 462,1 4621 462 (462, 629 62 62, 5385 538 538, 63,7. 637 63,7 63 63,7) fim 3,1 31 (3, 08 0 0, 19 0,7 07 CR10 CR 10 CR-1 5,2 52 37 3, 0,3 03 trei namento (FMR (GT 17, (PEmáx 14 32, 21, 18, 38, 5, (5 462, 46 (462 53 63, (3 CR1 CR- ( (46 (4

Abstract Introduction Chronic obstructive pulmonary disease (COPD) not only restricts airflow but also induces sys-temic manifestations in individuals with the disease. Objective To evaluate the effect of a water-based aero-bic exercise program on respiratory muscle strength, thoracic mobility, dyspnea, and functional capacity in patients with COPD. Methods We conducted a blind randomized controlled trial with 22 patients with COPD, dividing them into a control group (CG) and a training group (TG). The TG participated in 24 sessions of a water aerobic exercise program, while the CG only partici-pated in the evaluations. Maximal respiratory pressure (MRP), dyspnea, and functional capacity were measured. Results When comparing the MRP values (cmH2O) in the pre- and post-training conditions, the results revealed a significant improvement in the TG [maximal inspiratory pressure (MIP): 74.8 ± 15.3 vs. 83.9 ± 17.2; maximal expi-ratory pressure (MEP): 141.5 ± 30.7 vs. 157.6 ± 32.9], whereas no difference was observed for the CG (MIP: 55.5 ± 21.8 vs. 54.4 ± 18.4; MEP: 116.2 ± 40.3 vs. 109.3 ± 38.9). Regarding thoracic mobility in the pre- and post-training conditions, no significant difference was found for the CG, whilst for the TG there was a significant in-crease at the axillary level (cm) (5.9 ± 1.8 vs. 7.7 ± 1.1). With respect to functional capacity, there was a signifi-cant increase in walking distance during the six-minute walking test only in the TG when comparing pre- and post-training conditions (462.1 ± 62.9 vs. 538.5 ± 63.7). Lastly, the dyspnea results demonstrated that after the training period there was a major reduction in the scores of Medical Research Council (3.1 ± 0.8 vs. 1.9 ± 0.7) and Borg CR-10 scales (5.2 ± 0.8 vs. 3.7 ± 0.3) only for the TG. Conclusion The water aerobic exercise training promoted beneficial changes in respiratory mus-cle strength, thoracic mobility, functional capacity and dyspnea among patients with COPD. COPD (COPD systemic sys temic waterbased based aero bic strength 2 (CG . (TG) partici pated evaluations MRP, , (MRP) measured cmH2O cmHO cmH O (cmH2O pre posttraining post MIP (MIP) 748 74 8 74. 153 15 3 15. vs 839 83 9 83. 17.2 172 17 expiratory expi ratory MEP (MEP) 1415 141 5 141. 307 30 7 30. 1576 157 6 157. 32.9, 329 32.9 32 32.9] (MIP 555 55 55. 218 21 21. 544 54 4 54. 18.4 184 18 1162 116 116. 403 40 40. 1093 109 109. 38.9. 389 38.9 38 38.9) crease cm (cm 5.9 59 (5. 1 1. 77 7. 1.1. 11 1.1 1.1) signifi cant sixminute six minute 462.1 4621 462 (462. 629 62 62. 5385 538 538. 63.7. 637 63.7 63 63.7) Lastly 3.1 31 (3. 08 0 0. 19 0.7 07 CR10 CR 10 CR-1 5.2 52 37 3. 0.3 03 mus cle (TG (MRP 17. (MEP 14 32. 18. 38. 5. (5 462. 46 (462 53 63. (3 CR1 CR- ( (46 (4

Abstract This manuscript explored film production for food packaging using Ecovio® and natural additives (Babassu, Castor, and Cotton Vegetable Oil), emphasizing the oil’s maleinization to optimize compatibility with the polymer. The thermogravimetric analysis revealed variations in the maximum thermal decomposition temperature of maleinized vegetable oils (Thermal event II; natural oil to maleinized oil): from 402 to 338 °C (Babassu), 441 to 446 °C (Castor), and 413 to 430 °C (Cotton). The films were produced by casting, resulting in average thicknesses varying between 0.047 and 0.065 mm, and presented low surface defects. Optical micrographs showed that films with maleinized vegetable oil were more homogeneous due to maleic anhydride. Infrared spectroscopy showed that unsaturated fatty acid bonds affected the matrix and oil interaction. The presence of oils impacted the thermal stability, moisture content, and mechanical properties. This research promotes the use of renewable resources, contributing to the development of sustainable packaging. Ecovio Babassu, Babassu (Babassu Castor Oil, Oil , Oil) s polymer Thermal II oil) 40 33 C (Babassu) 44 (Castor) 41 43 Cotton. . (Cotton) casting 0047 0 047 0.04 0065 065 0.06 mm defects anhydride interaction stability content properties resources 4 3 (Castor (Cotton 004 04 0.0 006 06 00 0.

RESUMO A nefropatia membranosa é uma glomerulopatia, cujo principal alvo acometido é o podócito, e acarreta consequências na membrana basal glomerular. Tem maior frequência em adultos, principalmente acima dos 50 anos. A apresentação clínica é a síndrome nefrótica, mas muitos casos podem evoluir com proteinúria não nefrótica assintomática. O mecanismo consiste na deposição de complexos imunes no espaço subepitelial da alça capilar glomerular com subsequente ativação do sistema do complemento. Grandes avanços na identificação de potenciais antígenos alvo têm ocorrido nos últimos vinte anos, e o principal é a proteína “M-type phospholipase-A2 receptor” (PLA2R) com o anticorpo anti-PLA2R circulante, o que possibilita avaliar a atividade e o prognóstico dessa nefropatia. Essa via de lesão corresponde aproximadamente a 70% a 80% dos casos da nefropatia membranosa caracterizada como primária. Nos últimos 10 anos vários outros antígenos alvo potenciais têm sido identificados. Esta revisão se propõe a apresentar de modo didático aspectos clínicos, etiopatogênicos e terapêuticos da nefropatia membranosa, incluídos os casos com ocorrência no transplante renal. glomerulopatia podócito adultos 5 assintomática complemento Mtype M type phospholipaseA2 phospholipaseA phospholipase A2 phospholipase-A receptor PLA2R PLAR PLA R (PLA2R antiPLA2R antiPLAR anti circulante 70 80 primária 1 identificados clínicos renal antiPLA 7 8

ABSTRACT Membranous nephropathy is a glomerulopathy, which main affected target is the podocyte, and has consequences on the glomerular basement membrane. It is more common in adults, especially over 50 years of age. The clinical presentation is nephrotic syndrome, but many cases can evolve with asymptomatic non-nephrotic proteinuria. The mechanism consists of the deposition of immune complexes in the subepithelial space of the glomerular capillary loop with subsequent activation of the complement system. Great advances in the identification of potential target antigens have occurred in the last twenty years, and the main one is the protein “M-type phospholipase-A2 receptor” (PLA2R) with the circulating anti-PLA2R antibody, which makes it possible to evaluate the activity and prognosis of this nephropathy. This route of injury corresponds to approximately 70% to 80% of cases of membranous nephropathy characterized as primary. In the last 10 years, several other potential target antigens have been identified. This review proposes to present clinical, etiopathogenic and therapeutic aspects of membranous nephropathy in a didactic manner, including cases that occur during kidney transplantation. glomerulopathy podocyte membrane adults 5 age syndrome nonnephrotic non proteinuria system Mtype M type phospholipaseA2 phospholipaseA phospholipase A2 A phospholipase-A receptor PLA2R PLAR PLA R (PLA2R antiPLA2R antiPLAR anti antibody 70 80 primary 1 identified manner transplantation antiPLA 7 8

Abstract Objective To evaluate the efficacy and safety of romiplostim (thrombopoietin-receptor agonist) in the treatment of pediatric immune thrombocytopenia (ITP). Methods Searches were conducted in MEDLINE, EMBASE, LILACS, Cochrane Central Register of Controlled Trials and ClinicalTrials.gov (from January 2011 to August 2021). Randomized controlled trials (RCTs), double-blind, comparing romiplostim with a placebo in pediatric persistent or chronic ITP were included. The primary outcome was the overall response rate (platelets ≥ 50 × 109/L) in the absence of rescue therapy for at least two consecutive weeks. The secondary endpoints were the minimization of clinically significant bleeding and the necessity for rescue treatments and the maximization of safety (incidence of overall adverse events) and durable response (maintaining platelet counts for at least twelve weeks). Results Two double-blind randomized placebo-controlled trials (84 participants) were included in this systematic review. Our data showed that, compared to the placebo group, the proportion of patients achieving durable platelet response was significantly higher in the romiplostim group (p= 0.003, RR = 6.34, 95%CI = 1.89 - 21.23), as was the overall response in the romiplostim group (p= 0.002, RR = 3.62, 95%CI = 1.63 - 8.03). Significant bleeding incidents (p= 0.49), overall adverse events (p= 0.71) and the need for rescue treatment (p= 0.13) were not statistically different between the romiplostim and placebo groups. Conclusions Romiplostim might improve both durable and overall platelet response in children and adolescents with ITP, compared to a placebo. More clinical trials are needed to evaluate the efficacy and safety of romiplostim and to compare it with other second-line treatments that are being used in pediatric ITP. thrombopoietinreceptor thrombopoietin receptor agonist . (ITP) MEDLINE EMBASE LILACS ClinicalTrialsgov ClinicalTrials gov from 201 2021. 2021 2021) RCTs, RCTs , (RCTs) doubleblind, doubleblind double blind, blind platelets 5 109/L 109L L 109 weeks incidence maintaining weeks) placebocontrolled 84 (8 participants review p= p (p 0003 0 003 0.003 634 6 34 6.34 95CI CI 95 189 1 89 1.8 21.23, 2123 21.23 21 23 21.23) 0002 002 0.002 362 3 62 3.62 163 63 1.6 8.03. 803 8.03 8 03 8.03) 0.49, 049 0.49 49 0.49) 0.71 071 71 0.13 013 13 groups secondline second line (ITP 20 202 (RCTs 10 ( 000 00 0.00 6.3 9 18 1. 212 21.2 2 36 3.6 16 80 8.0 04 0.4 4 0.7 07 7 0.1 01 0.0 6. 21. 3. 8. 0.

Resumo Objetivo: O presente estudo teve por objetivo analisar as representações sociais da Psicologia numa amostra de inquiridos portugueses, contribuindo, assim, para um maior entendimento do significado social dessa área científica. Método: Foi realizada uma tarefa de associação em uma amostra composta de 205 portugueses aos quais foi dado como estímulo a palavra “Psicologia”. Os dados foram analisados através de análise de conteúdo, com apoio do software Max-Qda. Resultados: Os principais resultados evidenciam uma maior diversidade de representações face a estudos anteriores. No entanto, a representação dominante em termos interventivos continua a ser a clínica curativa e o paradigma médico. Conclusão: Esta pesquisa permitiu evidenciar a necessidade de que profissionais de Psicologia e entidades que os representam reforcem a visibilidade e a consciência da comunidade em geral sobre as áreas de aplicação da Psicologia, quer no contexto científico, quer no profissional. Objetivo contribuindo assim científica Método 20 Psicologia. . “Psicologia” conteúdo MaxQda. MaxQda Max Qda. Qda Max-Qda Resultados anteriores entanto médico Conclusão científico profissional 2 “Psicologia

Abstract Objective: The present study aimed to analyse the social representations of Psychology in a sample of Portuguese respondents, thus contributing to a better understanding of the social meaning of this scientific area. Method: A free association task was performed by a sample of 205 Portuguese individuals who were given the word “Psychology” as a stimulus. Data were analysed using content analysis, supported by the Max-Qda software. Results: The main results show a greater diversity of representations compared to previous studies. However, the dominant representation in terms of intervention is still the curative clinic and the medical paradigm. Conclusion: This research made it possible to highlight the need for Psychology professionals, and the entities that represent them, to reinforce the visibility and awareness of the community in general, of the application areas both in the scientific and professional context. Objective respondents area Method 20 “Psychology stimulus analysis MaxQda Max Qda software Results studies However paradigm Conclusion professionals them general context 2

Resumo Como há poucos estudos do Teste de Pfister no contexto de avaliação para o manuseio de arma, o objetivo foi descrever as características de personalidade de vigilantes e candidatos para manusear armas de fogo (n= 112) quando comparados com pessoas da população em geral (n= 288). Os instrumentos de coleta de dados foram um questionário para recolher informações sociodemográficas e o Teste de Pfister. Para a análise de dados utilizou-se testes não paramétricos e análise de regressão linear múltipla. Os candidatos ao manuseio de arma apresentaram características de mais rigidez, ansiedade e imaturidade com predisposição para serem mais oposicionistas e ambivalentes em relação aos seus sentimentos. Nota-se ainda a necessidade de mais estudos com amostras mais abrangentes e diversificadas. n= n (n 112 288. 288 . 288) utilizouse utilizou se múltipla rigidez sentimentos Notase Nota diversificadas 11 28 1 2

Abstract As there are few Pfister Test studies in the context of assessment for handling a firearm, the objective was to describe the personality characteristics of security guards and candidates for handling firearms (n= 112) when compared with people from the general population (n= 288). The data collection instruments were a questionnaire to collect sociodemographic information and the Pfister Test. For data analysis, nonparametric tests and multiple linear regression analysis were used. Candidates for handling weapons showed characteristics of more rigidity, anxiety and immaturity with a predisposition to be more oppositional and ambivalent in relation to their feelings. There is also a need for further studies with more comprehensive and diversified samples. firearm n= n (n 112 288. 288 . 288) used rigidity feelings samples 11 28 1 2

ABSTRACT Conservation management practices with minimum soil mobilization, maintenance of amounts of straw in the soil, and chiseling of ratoons interrows can be beneficial to soil quality, nutrition and sugarcane yield; however, the combination of these practices and their influence over the culture cycle should be better understood. This study aimed to assess the effects of levels of remaining straw and chiseling in the cultivation of ratoons on soil fertility, nutritional status and yield of stalks and sugar in one sugarcane cycle (five ratoons), under no-tillage and conventional tillage systems. The study was performed in Dourados municipality, Mato Grosso do Sul, Brazil, in areas with a Oxisol (Latossolo) with very clayey texture. Design in randomized blocks was adopted, with four repetitions, in a subdivided portions scheme. Portions were composed of levels of remaining straw (0, 50 and 100 %), annually, and collected alternately in odd years (0I) and even years (0P) established after the plant harvest; sub-portions were composed of systems with and without chiseling. In the fourth ratoon, leaf diagnosis was made with quantification of macro-nutrient contents, and during the fifth ratoon soil samples were collected for chemical analyses. By the end of the cycle, accumulated yields of stalks and sugar were determined. In both management systems, keeping 100 % of straw improved soil fertility and kept higher yield levels in one sugarcane cultivation cycle, while chiseling did not influence soil fertility, nutrition and sugarcane yield. The use of no-tillage farming for sugarcane cultivation proved to be feasible in corrected environments, and did not reduce stalk and sugarcane yield. Straw removal influenced nutrient leaf contents, regardless of soil management. mobilization quality however understood five ratoons, , ratoons) notillage no municipality Sul Brazil Latossolo (Latossolo texture adopted repetitions scheme 0, 0 (0 5 10 %, %) annually 0I I (0I 0P P (0P harvest subportions sub macronutrient macro contents analyses determined environments ( 1

RESUMEN Objetivos: describir la experiencia de la familia en relación con la vida diaria de un miembro familiar que experimenta sufrimiento mental. Métodos: se realizó un estudio cualitativo, descriptivo y fenomenológico basado en la ontología de la experiencia de Merleau-Ponty en diez hogares de una ciudad en el estado de Bahía, Brasil, donde residen 24 participantes de los Círculos de Intersubjetividad. Las descripciones producidas fueron sometidas a la técnica de Análisis de Ambigüedad. Resultados: las descripciones se clasificaron en: la ausencia como un poder creativo del sentido de “ser” y “no ser una familia”; y la exclusión y aceptación como expresiones del sufrimiento mental en el contexto familiar. Consideraciones Finales: la experiencia del sufrimiento mental en la vida diaria de la familia está marcada por sentimientos ambiguos, como alegría y tristeza, decepción y satisfacción, falta de amor y amor. Sin embargo, experimentar estos sentimientos puede movilizar el deseo de “convertirse” en una familia, aumentar el sentido de autonomía e independencia, y promover la formación de nuevas configuraciones familiares. Objetivos Métodos cualitativo MerleauPonty Merleau Ponty Bahía Brasil 2 Intersubjetividad Ambigüedad Resultados “ser no familia” Finales ambiguos tristeza satisfacción embargo convertirse “convertirse independencia familiares

ABSTRACT Objectives: to describe the family’s experience in relation to daily life with a family member experiencing mental suffering. Methods: a qualitative, descriptive, phenomenological study grounded in Merleau-Ponty’s ontology of experience was conducted in ten households in a city in the state of Bahia, Brazil, where 24 participants of the Intersubjectivity Wheels reside. The descriptions produced were subjected to the Ambiguity Analytics technique. Results: the descriptions were categorized into: absence as a creative power of the sense of “being” and “not being a family”; and exclusion and acceptance as expressions of mental suffering in the family context. Final Considerations: the experience of mental suffering in the family’s daily life is marked by ambiguous feelings, such as joy and sadness, disappointment and satisfaction, lack of love and love. However, experiencing these feelings can mobilize the desire to “become” a family, increase the sense of autonomy and independence, and drive the formation of new family configurations. Objectives familys s Methods qualitative descriptive MerleauPontys Merleau Ponty Bahia Brazil 2 reside technique Results into “being not family” context Considerations sadness satisfaction However become “become independence configurations

RESUMO Objetivos: descrever a experiência da família em relação ao cotidiano com o familiar em sofrimento mental. Métodos: estudo qualitativo, descritivo, do tipo fenomenológico, fundamentado na ontologia da experiência de Merleau-Ponty, realizado em dez domicílios de uma cidade do estado da Bahia (Brasil), onde residem os 24 participantes das Rodas de Intersubjetividade. As descrições produzidas foram submetidas à técnica Analítica da Ambiguidade. Resultados: as descrições foram categorizadas em: ausência como potência criadora do sentido de “ser” e “não ser família”; e exclusão e acolhimento como expressão do sofrimento mental no contexto da família. Considerações Finais: a experiência do sofrimento mental no cotidiano da família é marcada por sentimentos ambíguos, como alegria e tristeza, decepção e satisfação, desamor e amor. Entretanto, a vivência desses sentimentos pode mobilizar o desejo de “tornar-se” família, aumentar o senso de autonomia e independência, e impulsionar a formação de novas configurações familiares. Objetivos Métodos qualitativo descritivo fenomenológico MerleauPonty, MerleauPonty Merleau Ponty, Ponty Merleau-Ponty Brasil, Brasil , (Brasil) 2 Intersubjetividade Ambiguidade Resultados “ser não família” Finais ambíguos tristeza satisfação amor Entretanto tornarse tornar se “tornar-se independência familiares (Brasil

RESUMO Objetivo: Aborda compreensões de cientistas da informação acerca do conceito de informação. Especificamente, discute inscrições desses especialistas à luz da epistemologia política de Bruno Latour. Método: Sob abordagem metodológica da semiótica material, utiliza a noção de “inscrição” e o procedimento de “tradução” para fins de descrição e análise bibliográficas das inscrições de especialistas estrangeiros e brasileiros via questionário. Resultado: Constata diferentes redes semiótico-materiais que compreendem o conceito de informação. Dentre outras, compreende-o como multifacetado e polissêmico, partilham conceituações próprias e outras que utilizam a própria literatura para tal conceituação. Conclusões: A construção dessas redes semiótico-materiais que compreendem o conceito de informação por meio de Bruno Latour permite apreender as relações entre saberes e interesses contraditórios do conhecimento científico, enquanto processos de identificação e diferenciação político-epistemológicos, para além de qualquer purificação disciplinar objetivista via epistemologia informacional ou epistemologia ciência da informação. Objetivo Especificamente Método material inscrição “inscrição tradução “tradução questionário Resultado semióticomateriais semiótico materiais compreendeo compreende polissêmico conceituação Conclusões científico políticoepistemológicos, políticoepistemológicos político epistemológicos, epistemológicos político-epistemológicos

ABSTRACT Objective: It addresses understandings of information scientists about the concept of information. Specifically, it discusses the inscriptions of these specialists in the light of Bruno Latour's political epistemology. Methods: Under a methodological approach of material semiotics, it uses the notion of “inscription” and the procedure of “translation” for the purpose of description and bibliographic analysis of the inscriptions of foreign and Brazilian specialists via questionnaire. Results: It notes different semiotic-material networks that comprise the concept of information. Among others, they understand it as multifaceted and polysemic, they share their own conceptualizations and others that use the literature itself for such conceptualization. Conclusions: The construction of these semiotic-material networks that comprise the concept of information through Bruno Latour allows apprehending the relationships between knowledge and contradictory interests of scientific knowledge, as processes of political-epistemological identification and differentiation, beyond any objectivist disciplinary purification via epistemology informational or information science epistemology. Objective Specifically Latours s Methods semiotics inscription “inscription translation “translation questionnaire Results semioticmaterial semiotic polysemic conceptualization Conclusions politicalepistemological epistemological differentiation

ABSTRACT To know the relationships between phenotypic and genetic variables in a germplasm collection of fruit crops is useful a pre-breeding and cultivar distinctness. A core collection of 23 peaches/nectarines (Prunus persica (L.) Batsch), and 16 Japanese plum (Prunus salicina Lindl. var. salicina) cultivars were evaluated for 33 and 29 characteristics (botanical/ productive) respectively during two growing seasons. Also, eight specific simple sequence repeats (SSRs) markers were analyzed in both species. Principal components analyses revealed seven characteristics (related to the size of the fruit and the firmness of the pulp) as the most important for the 23 peach/nectarine cultivars and four characteristics (yield, fruit size, soluble solids, and harvest time) for the 16 Japanese plum cultivars. These analyses revealed three cultivars of peaches (Diamond Princess, Dixon, and Dr. Davis) and three of nectarines (Ruby diamond, Artic sweet, Summer fire) with the highest values for fruit size and pulp firmness. Four Japanese plum cultivars (Angeleno, Flavor Rich, Red Heart, and Pink Delight) showed the highest values of yield, fruit size, soluble solids, and harvest time. Elite germplasms to carry out a breeding program were identified from both the phenotypic and genetic analysis. Additionally, cultivar-specific SSR alleles were identified and are a relevant tool for cultivar distinctness.