Resumo Este artigo oferece uma alternativa de recorte metodológico para o campo da Smart city, partindo de uma revisão bibliográfica temporal e análise empírica da Smart city Konza Technopolis (Quênia), da smartificação de São Paulo (SP/Brasil), e da Smart city Laguna (CE/Brasil). As experiências Smart city desenvolvem-se desde o final de 1990, detendo maior expressividade no espaço urbano a partir dos anos 2010, concomitantemente ao aumento das pesquisas a seu respeito. Atualmente, a temática apresenta elevado nível de discussão e amadurecimento e, dada sua amplitude, torna-se necessário o direcionamento analítico, devido às particularidades relativas às três categorias aqui apresentadas: (1) as Smart cities desenvolvidas a partir do zero; (2) as iniciativas voltadas às cidades consolidadas; e (3) os empreendimentos imobiliários. Quênia, Quênia , (Quênia) SP/Brasil, SPBrasil SP/Brasil SP Brasil (SP/Brasil) CE/Brasil. CEBrasil CE/Brasil . CE (CE/Brasil) desenvolvemse desenvolvem se 1990 2010 respeito Atualmente amplitude tornase torna analítico apresentadas 1 (1 zero 2 (2 consolidadas 3 (3 imobiliários (Quênia (SP/Brasil (CE/Brasil 199 201 ( 19 20

Abstract This article offers an alternative methodological framework for the smart city field, starting from a chronological literature review and empirical analysis of the smart city Konza Technopolis (Kenya), the smartification of São Paulo (State of São Paulo, Brazil), and the Smart City Laguna (State of Ceará, Brazil). Smart city experiences have been developed since the late 1990s, with greater expressiveness in the urban space from the 2010s onwards, concomitantly with an increase in the number of studies about the theme. Currently, the theme demonstrates a high level of discussion and maturity. Given its breadth, an analytical focus is necessary to address the particularities related to the three categories presented here: (1) smart cities developed from scratch; (2) initiatives aimed at consolidated cities; and (3) real estate developments. field Kenya, Kenya , (Kenya) State Brazil, Brazil Brazil) Ceará Brazil. . 1990s s onwards Currently maturity breadth here 1 (1 scratch 2 (2 3 (3 developments (Kenya (

Anabolic steroids are often consumed by both amateur and professional sports practitioners with the aim of improving their performance and for the rapid gain of muscle mass. Nandrolone is one of the main steroids consumed and is, frequently, acquired illegally or from dubious sources, and this raises serious concerns regarding the quality of the products. This work sought to qualitatively and quantitatively evaluates oily, nandrolone-based anabolic steroids confiscated by the Federal Police Department, in the triple border (Paraguay-Brazil-Argentina, PY-BR-AR). For the quantitative study, we conducted a methodological validation analysis based on the application of solvent extraction and GC-MS (gas chromatography-mass spectrometry). A total of 40 samples of nandrolone steroids (as described on the label) were thoroughly investigated. The results obtained showed that 90% of the samples analyzed contained the active ingredient but 67.5% of these samples exhibited concentrations below the values indicated on the label; these products are thus considered to be of low quality and their consumption may pose serious risks to the consumers. The findings of this study point to the importance of enforcing regulatory controls on the sale of anabolic steroids with a view to inhibiting the consumption of counterfeit drugs that can pose serious risks to the health of consumers. mass frequently sources oily nandrolonebased Department ParaguayBrazilArgentina, ParaguayBrazilArgentina Paraguay Brazil Argentina, Argentina (Paraguay-Brazil-Argentina PYBRAR. PYBRAR PY BR AR . PY-BR-AR) GCMS GC MS gas chromatographymass chromatography spectrometry. spectrometry spectrometry) 4 as label investigated 90 675 67 5 67.5 consumers PY-BR-AR 9 6 67.

Fruits of Schinus terebinthifolia Raddi were investigated. A fast and efficient method for the simultaneous determination of 11 polyphenolic substances by high performance liquid chromatography-diode array detector (HPLC-DAD) was applied. Limits of quantification ranged between 0.78 and 3.14 mg L-1. High concentrations of kaempferol were found. An exploratory evaluation was performed using principal component analysis (PCA) for fruit origin differentiation. Total phenolic content (TPC) ranged from 274 to 517 mg GAE 100 g-1; total flavonoid content (TFC) ranged from 101 to 283 mg QE 100 g-1. In vitro analyses showed that antioxidant capacity with 2,2-diphenyl-1-picrylhydrazyl (DPPH) ranged from 1.7 to 7 µM DPPH 100 g-1. The bacteriostatic and bactericidal effect were also evaluated against: Bacillus subtilis, B. cereus, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella choleraesuis, Candida albicans and C. glabrata, using broth microdilution assay. It can be inferred that S. terebinthifolia Raddi fruit has the potential to act as an ally in the search for new alternatives in the action against pathogens, and it can be used as a potential natural antioxidant and antimicrobial agent. Metals (Cu, Fe, Mg, Mn and Zn) were also determined by flame atomic absorption spectrometry (FAAS), with emphasis on high concentrations of Mg, Zn and Fe. investigated 1 chromatographydiode chromatography diode HPLCDAD HPLC DAD (HPLC-DAD applied 078 0 78 0.7 314 3 14 3.1 L1. L1 L 1. L-1 found PCA (PCA differentiation TPC (TPC 27 51 10 g1 g g-1 TFC (TFC 28 g1. 2,2diphenyl1picrylhydrazyl 22diphenyl1picrylhydrazyl diphenylpicrylhydrazyl 2,2 diphenyl picrylhydrazyl 2 (DPPH 17 subtilis B cereus aureus coli aeruginosa choleraesuis C glabrata assay S pathogens agent Cu, Cu (Cu Fe Mg FAAS, FAAS , (FAAS) 07 0. 31 3. L- 5 g- 2diphenyl1picrylhydrazyl 22 2, (FAAS

High-density polyethylene (HDPE) geomembranes are commonly used as an environmental protection liner due to their good chemical and mechanical resistances and low cost. Ultraviolet (UV) radiation is an essential issue in durability studies for pond applications. This study evaluated a 1.5-mm thick HDPE geomembrane exposed to ultraviolet fluorescent radiation for 8760 h in a laboratory and thermoanalytical and physical analyses were conducted towards the understanding of its performance after exposure. According to the results, although the geomembrane maintained the ductile behavior, it showed a 52.48% final decrease in stress crack resistance (SCR) compared to virgin SCR. Moreover, a considerable antioxidant depletion occurred after 8760 h exposure shown by the Std. OIT (standard oxidative-induction time) results, demonstrating a Std. OIT value decrease of 89.19% compared to the virgin Std. OIT. Such a behavior contributed to the susceptibility of thermal effects in the DSC (differential scanning calorimetry) curves and the losses observed in the SCR values, attesting the geomembrane’s oxidative degradation mechanism occurred and changed the polymer’s structure. Highdensity High density (HDPE cost UV (UV applications 1.5mm 15mm mm 1.5 1 5 876 results 5248 52 48 52.48 (SCR Moreover Std standard oxidativeinduction induction time 8919 89 19 89.19 differential calorimetry values s polymers polymer structure 5mm 15 1. 87 524 4 52.4 891 8 89.1 52. 89.

Species from Pavonia genus (Malvaceae) are traditionally used as antioxidant, n anti inflammatory and antimicrobial remedies. Previous studies have revealed their diversity of specialized metabolites widely used in the development of new medicines. This is the first study on Pavonia glazioviana Gurke, a Brazilian species known as “Malva da Chapada”. The research led to identify fifteen compounds: 132 (S) hydroxy pheophytin a; and 132(S) hydroxy 173 ethoxyphaeophorbide, n decanol, cycloart 23Z ene 3β,25 diol, cycloart 24S 25 ene 3β,24 diol, sitosterol 3 O β D glucopyranoside, stigmasterol 3 O β D glucopyranoside, quercetin, acacetin, kaempferol, tiliroside, 5 hydroxy 3,7,8,4’ tetramethoxyflavone, 5,7 dihydroxy 3,8,4’ trimethoxyflavone, 5,7 dihydroxy 4’ methoxyflavone, 5,7,4’ trihydroxy 3,8 dimethoxyflavone and 5,7,4’ trihydroxy 3 methoxyflavone. The major flavonoids were tested for their antimicrobial activity, and the compound 5,7 dihydroxy 3,8,4’ trimethoxyflavone showed strong activity against Escherichia coli (MIC = 512 μg mL1), Pseudomonas aeruginosa (MIC = 512 μg mL1), Candida albicans (MIC = 512 μg mL1), Candida tropicalis (MIC = 512 μg mL1), Candida parapsilosis (MIC = 512 μg mL1), Aspergillus flavus (MIC = 512 μg mL1) and A. fumigantus (MIC = 512 μg mL1). The total phenolic content, flavonoid content, and radical scavenging potential were determined showing its great production of phenolics and flavonoids, along with interesting radical scavenging potential (DPPH EC50 = 6.36 ± 0.029 mg mL 1). Our findings contributed to characterize P. glazioviana as a source of methoxylated flavonoids with antimicrobial potential. Malvaceae (Malvaceae antioxidant remedies medicines Gurke Malva Chapada. Chapada . Chapada” compounds 13 S (S 132S 132(S 17 ethoxyphaeophorbide decanol Z 3β25 3β 3β,2 diol 2 3β24 24 glucopyranoside quercetin acacetin kaempferol tiliroside 3,7,8,4 3784 7 8 4 tetramethoxyflavone 57 5, 3,8,4 384 methoxyflavone 5,7,4 574 38 3, MIC 51 mL1, mL1 , A mL1. content DPPH EC EC5 636 6 36 6.3 0029 0 029 0.02 1. 1 1) P 3β2 3β, 3,7,8, 378 3,8, 5,7, 63 6. 002 02 0.0 3,7,8 37 00 0. 3,7, 3,7

RESUMO: O uso de métodos não destrutivos e de baixo custo para determinação de área foliar tem ganhado importantes aplicações. Os objetivos da pesquisa foram (i) propor um método não destrutivo para estimar a área foliar da cultura da mamona e (ii) construir equações que estimem com precisão e rapidez a área foliar da espécie. Foram coletadas mil folhas sadias e expandidas de cinco cultivares de mamona (New Zealand Purple, Sipeal, Carmencita, Amarelo de Irecê e IAC-80), sendo coletadas 200 folhas de cada uma. O comprimento máximo, largura máxima e área foliar foram calculados para cada folha. Foi calculado o produto entre comprimento e largura (LW). Foram realizados testes com diferentes modelos de regressão linear e não linear entre área foliar e dimensões lineares das folhas de cada cultivar. Os modelos utilizados foram linear, linear sem intercepto e potência. Os critérios para escolha dos melhores modelos para estimar a área foliar da mamona foram maior coeficiente de determinação, maior coeficiente de correlação linear de Pearson, menor critério de informação de Akaike, maior índice de concordância de Willmott e menor raiz do erro quadrático médio. As equações que apresentaram melhores critérios para estimativa da área foliar das cultivares de mamona foram aquelas que utilizaram o produto entre comprimento e largura, em comparação às equações que utilizaram apenas uma dimensão foliar. O modelo ŷ = 0,439 × LW pode ser utilizado para estimar com precisão e rapidez a área foliar da mamona por meio de medidas lineares das folhas, utilizando o produto entre comprimento e largura (LW), independente da cultivar escolhida. RESUMO aplicações i (i ii (ii espécie New Purple Sipeal Carmencita IAC80, IAC80 IAC 80 , IAC-80) 20 máximo folha LW. . (LW) potência Pearson Akaike médio 0439 0 439 0,43 LW, escolhida IAC8 8 IAC-80 2 (LW 043 43 0,4 IAC-8 04 4 0, IAC-

ABSTRACT: Using non-destructive and low-cost methods to determine leaf area has gained important applications. The research objectives were (i) to propose a non-destructive method to estimate the leaf area of castor bean crops and (ii) to build equations that accurately and quickly estimate the leaf area of specie. One thousand healthy and expanded leaves of five castor bean cultivars (New Zealand Purple, Sipeal, Carmencita, Amarelo de Irecê, and IAC-80) were collected, and 200 leaves were collected from each. The maximum length, maximum width, and leaf area were calculated for each leaf. The product between length and width (LW) were calculated. We performed tests with different linear and non-linear regression models between leaf area and linear leaf dimensions of each cultivar. The models used were linear, linear without intercept, and power. The criteria for choosing the best models to estimate the leaf area of castor beans were a higher coefficient of determination, more elevated Pearson’s linear correlation coefficient, lower Akaike information criterion, higher Willmott agreement index, and smallest root mean square error. The equations that presented the best criteria for estimating the leaf area of castor bean cultivars were those that used the product between length and width, compared to equations that used only one leaf dimension. The model ŷ = 0.439 × LW can be used to accurately and quickly estimate the castor bean leaf area through linear measurements of the leaves, using the product between length and width (LW), regardless of the cultivar chosen. ABSTRACT nondestructive non destructive lowcost low cost applications i (i ii (ii specie New Purple Sipeal Carmencita Irecê IAC80 IAC 80 IAC-80 20 (LW nonlinear intercept power determination Pearsons Pearson s criterion index error dimension 0439 0 439 0.43 LW, , chosen IAC8 8 IAC-8 2 043 43 0.4 IAC- 04 4 0.

RESUMO Objetivo: Examinar a associação entre o tempo de tela autorreportado e os sintomas de estresse, ansiedade e depressão em adolescentes. Métodos: Foi realizado estudo com delineamento transversal com 982 adolescentes entre 12-15 anos, matriculados na rede pública de ensino da cidade de Jacarezinho (PR). Para mensurar o tempo de tela, os adolescentes responderam à pergunta: “Considerando um dia típico, quanto tempo você passa assistindo TV, jogando videogame, usando computador ou smartphone?”. O questionário DASS-21 (versão curta) foi utilizado para avaliar os sintomas de depressão, ansiedade e estresse. Análises brutas e ajustadas (idade, sexo e nível de escolaridade materna) entre tempo de tela e indicadores de saúde mental foram realizadas por meio do modelo de regressão linear generalizado, com distribuição de Poisson, adotando a significância de p<0,05. Resultados: Maiores sintomas depressivos foram observados em adolescentes com tempo de tela de 4–6 horas/dia (RP 1,35, IC95% 1,13–1,61) e ≥6 horas/dia (RP 1,88, IC95% 1,62–2,19) quando comparados com seus pares com ≤2 horas/dia. O mesmo foi observado para os sintomas de ansiedade com tempo de tela de 4–6 horas/dia (RP 1,23, IC95% 1,04–1,46) e ≥6 horas/dia (RP 1,50, IC95% 1,28–1,77); e estresse, com 4–6 horas/dia (RP 1,25, IC95% 1,08–1,44) e ≥6 horas/dia (RP 1,49, IC95% 1,30–1,71), também comparados com seus pares com ≤2 horas/dia. Conclusões: O tempo de tela foi associado positivamente com os sintomas de depressão, ansiedade e estresse em adolescentes. Atenção especial deve ser dada àqueles que passam mais de quatro horas por dia em frente a uma tela. Objetivo Métodos 98 1215 12 15 12-1 anos PR. PR . (PR) pergunta Considerando típico TV videogame smartphone. smartphone smartphone?” DASS21 DASS 21 DASS-2 versão curta idade, idade (idade materna generalizado Poisson p005 p 0 05 p<0,05 Resultados 46 4 6 4– horasdia RP 135 1 35 1,35 IC95 IC 1,13–1,61 113161 13 61 ≥ 188 88 1,88 1,62–2,19 162219 62 2 19 ≤ 123 23 1,23 1,04–1,46 104146 04 150 50 1,50 1,28–1,77 128177 28 77 1,28–1,77) 125 25 1,25 1,08–1,44 108144 08 44 149 49 1,49 1,30–1,71, 130171 1,30–1,71 , 30 71 1,30–1,71) Conclusões 9 121 12- (PR smartphone? DASS2 DASS- p00 p<0,0 3 1,3 IC9 1,13–1,6 11316 18 8 1,8 1,62–2,1 16221 1,2 1,04–1,4 10414 5 1,5 1,28–1,7 12817 7 1,08–1,4 10814 14 1,4 13017 1,30–1,7 p0 p<0, 1, 1,13–1, 1131 1,62–2, 1622 1,04–1, 1041 1,28–1, 1281 1,08–1, 1081 1301 1,30–1, p<0 1,13–1 113 1,62–2 162 1,04–1 104 1,28–1 128 1,08–1 108 130 1,30–1 p< 1,13– 11 1,62– 16 1,04– 10 1,28– 1,08– 1,30– 1,13 1,62 1,04 1,28 1,08 1,30 1,1 1,6 1,0

ABSTRACT Objective: To examine the associations between self-reported screen time and symptoms of stress, anxiety, and depression in adolescents. Methods: A cross-sectional study was conducted with 982 adolescents aged between 12 and 15 years, enrolled in public schools in Jacarezinho (PR), Brazil. Screen time was assessed by the question “Considering a typical day, how much time do you spend watching TV, playing videogame, using computer or smartphone?” The DASS-21 questionnaire (short form) was used to assess symptoms of depression, anxiety, and stress. Crude and adjusted analyses (age, sex, and maternal level of education) between screen time and mental disorders symptoms were performed using general linear regression models, with Poisson distribution, with significance level at p<0.05. Results: Higher depressive symptoms were observed in adolescents who reported screen time of 4–6 hours/day (PR 1.35, 95%CI 1.13–1.61) and ≥6 hours/day (PR 1.88, 95%CI 1.62–2.19), compared with their pairs with <2 hours/day. The same was observed for anxiety symptoms with screen time of 4–6 hours/day (PR 1.23, 95%CI 1.04–1.46) and ≥6 hours/day (PR 1.50, 95%CI 1.28–1.77); and stress, with 4–6 hours/day (PR 1.25, 95%CI 1.08–1.44) and ≥6 hours/day (PR 1.49, 95%CI 1.30–1.71), also compared with their pairs with <2 hours/day. Conclusions: Screen time was positively associated with depressive, anxiety, and stress symptoms in adolescents. Special attention should be given to those who spend more than four hours a day in front of a screen. Objective selfreported self Methods crosssectional cross sectional 98 1 years PR, PR , (PR) Brazil Considering TV videogame smartphone smartphone? DASS21 DASS 21 DASS-2 short form age, age (age sex education models distribution p005 p 0 05 p<0.05 Results 46 4 6 4– hoursday 135 35 1.35 95CI CI 95 1.13–1.61 113161 13 61 ≥ 188 88 1.88 1.62–2.19, 162219 1.62–2.19 62 2 19 1.62–2.19) < 123 23 1.23 1.04–1.46 104146 04 150 50 1.50 1.28–1.77 128177 28 77 1.28–1.77) 125 25 1.25 1.08–1.44 108144 08 44 149 49 1.49 1.30–1.71, 130171 1.30–1.71 30 71 1.30–1.71) Conclusions 9 DASS2 DASS- p00 p<0.0 3 1.3 1.13–1.6 11316 18 8 1.8 16221 1.62–2.1 1.2 1.04–1.4 10414 5 1.5 1.28–1.7 12817 7 1.08–1.4 10814 14 1.4 13017 1.30–1.7 p0 p<0. 1. 1.13–1. 1131 1622 1.62–2. 1.04–1. 1041 1.28–1. 1281 1.08–1. 1081 1301 1.30–1. p<0 1.13–1 113 162 1.62–2 1.04–1 104 1.28–1 128 1.08–1 108 130 1.30–1 p< 1.13– 11 16 1.62– 1.04– 10 1.28– 1.08– 1.30– 1.13 1.62 1.04 1.28 1.08 1.30 1.1 1.6 1.0

RESUMO Objetivo: Analisar a associação entre a participação em exercícios físicos relacionados ao fitness (EFRF) e a insatisfação com a imagem corporal (IIC) em adolescentes e avaliar a interação entre os exercícios físicos e o estado nutricional nesta associação. Métodos: Estudo transversal realizado em 2015 com 799 adolescentes (10 a 16 anos) de 14 escolas públicas de Curitiba (PR), Brasil. A IIC foi avaliada por meio do Body Shape Questionnaire e da Escala de Silhuetas. A participação em EFRF foi avaliada pelo Questionário de Atividade Física para Adolescentes e classificada em “não pratica”, “pratica ≤300 minutos/semana” e “pratica >300 minutos/semana”. As regressões de Poisson e logística multinomial, ajustadas por sexo, maturação sexual e estado nutricional, analisaram a associação entre EFRF e IIC. Resultados: A prevalência de IIC foi de 28,3%; 52,4% dos adolescentes queriam reduzir a silhueta e 48,7% não praticavam a EFRF. Adolescentes que praticavam EFRF >300 minutos/semana tiveram prevalência 28% maior para algum nível de IIC (razão de prevalência — RP 1,28; intervalo de confiança de 95% — IC95% 1,08–1,52) e chance 46% menor de querer reduzir silhuetas (OR 0,54; 95IC% 0,35–0,82), comparados aos não praticantes. Não houve interação entre os EFRF e o estado nutricional na associação com IIC. Conclusões: Os adolescentes que praticam EFRF >300 minutos/semana estão mais propensos a apresentar algum nível de IIC e têm menores chances de reportar o desejo de aumentar silhuetas, independentemente do estado nutricional. Objetivo (EFRF (IIC Métodos 201 79 10 (1 1 anos PR, PR , (PR) Brasil Silhuetas pratica, pratica pratica” 300 ≤30 minutossemana minutos semana >30 minutos/semana. . multinomial sexo Resultados 28,3% 283 28 3 524 52 4 52,4 487 48 7 48,7 razão 1,28 128 95 IC95 IC 1,08–1,52 108152 08 46 OR 0,54 054 0 54 95IC 0,35–0,82, 035082 0,35–0,82 35 82 0,35–0,82) praticantes Conclusões 20 ( (PR 30 ≤3 >3 28,3 2 5 52, 48, 1,2 12 9 IC9 1,08–1,5 10815 0,5 05 03508 0,35–0,8 8 ≤ > 28, 1, 1,08–1, 1081 0, 0350 0,35–0, 1,08–1 108 035 0,35–0 1,08– 03 0,35– 1,08 0,35 1,0 0,3

ABSTRACT Objective: The aim of this study was to analyze the association between participation in fitness-related exercises (FRE) and body image dissatisfaction (BID) in adolescents and evaluate the interaction between physical exercise and nutritional status in this association. Methods: A cross-sectional study was conducted in 2015 involving 799 adolescents (10–16 years old) from 14 public schools in Curitiba (PR), Brazil. BID was assessed using the Body Shape Questionnaire and the Silhouette Scale. The FRE was classified as “does not practice,” “practices ≤300 min/week,” and “practices >300 min/week” by the Physical Activity Questionnaire for Adolescents. Poisson and multinomial logistic regressions, adjusted for sex, sexual maturation, and nutritional status analyzed the association of FRE and BID. Results: The BID prevalence was 28.3%; 52.4% of the adolescents wanted to reduce their silhouettes; and 48.7% did not practice FRE. Adolescents who practiced FRE >300 min/week had a 28% higher prevalence for some level of BID (PR 1.28; 95%CI 1.08–1.52) and a 46% lower chance of wanting to reduce silhouettes (OR 0.54; 95%CI 0.35–0.82), compared to nonpractitioners. There was no interaction between FRE and nutritional status in association with BID. Conclusions: The adolescents who practice FRE >300 min/week are likely to have some level of BID and are less likely to report the desire to increase their silhouettes, regardless of their nutritional status. Objective fitnessrelated fitness related (FRE (BID Methods crosssectional cross sectional 201 79 10–16 1016 10 16 (10–1 old 1 PR, PR , (PR) Brazil Scale does practice, practices 300 ≤30 min/week, minweek min week >30 regressions sex maturation Results 28.3% 283 28 3 524 52 4 52.4 487 48 7 48.7 1.28 128 95CI CI 95 1.08–1.52 108152 08 46 OR 0.54 054 0 54 0.35–0.82, 035082 0.35–0.82 35 82 0.35–0.82) nonpractitioners Conclusions 20 10–1 101 (10– 30 ≤3 >3 28.3 2 5 52. 48. 1.2 12 9 1.08–1.5 10815 0.5 05 03508 0.35–0.8 8 10– (10 ≤ > 28. 1. 1.08–1. 1081 0. 0350 0.35–0. (1 1.08–1 108 035 0.35–0 ( 1.08– 03 0.35– 1.08 0.35 1.0 0.3

Resumo Objetivo Analisar a relação entre o índice de vulnerabilidade social e condição de fragilidade física e o delirium em idosos hospitalizados. Métodos Estudo transversal e analítico desenvolvido com idosos em um hospital no Sul do Brasil. Foram empregados os instrumentos de coleta questionário sociodemográfico, índice de vulnerabilidade social, marcadores do fenótipo de fragilidade física e Confusion Assessement Method. Utilizou-se estatística descritiva e inferencial. Resultados Dos 305 idosos avaliados, 59,4% eram do sexo feminino, 40,9% com idade superior a 80 anos e 92,6% com morbidades. Houve associação entre hospitalização e sexo feminino com baixa e média vulnerabilidade (64,8%; IC95% 55,9-72,7 e 63%; IC95% 53,2-71,8, respectivamente, com p=0,0262). O delirium foi observado em 29,5% (IC95% 22,3-38,4) dos idosos com idade superior a 60 anos com baixa vulnerabilidade, 17% (10,9-25,5) média, 14,5% (8,6-23,9) alta, com p=0,0151. Acima de 80 anos, não se observou associação entre delirium e o índice de vulnerabilidade, com p=0,235. A ocorrência de delirium atingiu 44,3% (32,5-56,7) idosos com baixa vulnerabilidade, 35% (22,1-50,5) média e 25% (12-44,9) alta. Não houve associação entre fragilidade e vulnerabilidade social, com p=0,927. Em idosos com 80 anos ou mais, prevaleceram os frágeis nos três estratos de vulnerabilidade (baixa 59,7%; média 57,5% e alta 56%), p=0,788. Conclusão A hospitalização e o delirium se associaram a mulheres mais jovens, pré-frágeis e provenientes de baixa e média vulnerabilidade social. A condição de fragilidade não se correlacionou à vulnerabilidade social. Destaca-se a necessidade de melhor compreensão dos fatores biopsicossociais que podem aumentar o delirium em idosos hospitalizados com baixa vulnerabilidade social. Brasil sociodemográfico Method Utilizouse Utilizou inferencial 30 avaliados 594 59 4 59,4 409 40 9 40,9 8 926 92 6 92,6 morbidades 64,8% 648 64 (64,8% IC95 IC 55,972,7 559727 55,9 72,7 55 72 7 55,9-72, 63% 63 53,271,8, 532718 53,2 71,8, 53 2 71 53,2-71,8 respectivamente p=0,0262. p00262 p p=0,0262 . 0 0262 p=0,0262) 295 29 5 29,5 (IC95 22,338,4 223384 22,3 38,4 22 3 38 22,3-38,4 17 10,925,5 109255 10,9 25,5 10 25 (10,9-25,5 145 14 14,5 8,623,9 86239 8,6 23,9 23 (8,6-23,9 p00151 0151 p=0,0151 p0235 235 p=0,235 443 44 44,3 32,556,7 325567 32,5 56,7 32 56 (32,5-56,7 35 22,150,5 221505 22,1 50,5 1 50 (22,1-50,5 1244,9 12449 12 44,9 (12-44,9 p0927 927 p=0,927 59,7% 597 575 57 57,5 56%, 56% , 56%) p0788 788 p=0,788 jovens préfrágeis pré Destacase Destaca 59, 40, 92, 64,8 (64,8 IC9 972 55,972, 55972 559 55, 727 72, 55,9-72 271 53,271,8 53271 532 53, 718 71,8 53,2-71, p0026 p=0,026 026 29, (IC9 338 22,338, 22338 223 22, 384 38, 22,3-38, 925 10,925, 10925 109 10, 255 25, (10,9-25, 14, 623 8,623, 8623 86 8, 239 23, (8,6-23, p0015 015 p=0,015 p023 p=0,23 44, 556 32,556, 32556 325 32, 567 56, (32,5-56, 150 22,150, 22150 221 505 50, (22,1-50, 1244 1244, 449 (12-44, p092 p=0,92 59,7 57, p078 78 p=0,78 64, (64, 97 55,972 5597 55,9-7 27 53,271, 5327 71, 53,2-71 p002 p=0,02 02 (IC 33 22,338 2233 22,3-38 10,925 1092 (10,9-25 62 8,623 862 (8,6-23 p001 01 p=0,01 p02 p=0,2 32,556 3255 (32,5-56 15 22,150 2215 (22,1-50 124 (12-44 p09 p=0,9 p07 p=0,7 (64 55,97 55,9- 53,271 53,2-7 p00 p=0,0 22,33 22,3-3 10,92 (10,9-2 8,62 (8,6-2 p0 p=0, 32,55 (32,5-5 22,15 (22,1-5 (12-4 (6 53,27 53,2- 22,3- (10,9- (8,6- p=0 (32,5- (22,1- (12- ( (10,9 (8,6 p= (32,5 (22,1 (12 (10, (8, (32, (22, (1 (10 (8 (32 (22 (3 (2

Abstract Objective To analyze the relationship between the social vulnerability index and physical frailty condition and delirium in hospitalized older adults. Methods Cross-sectional analytical study of older adults developed in a hospital in southern Brazil. The collection instruments used were a sociodemographic questionnaire, the social vulnerability index, physical frailty phenotype markers and the Confusion Assessment Method. Descriptive and inferential statistics were used. Results Of the 305 older adults evaluated, 59.4% were female, 40.9% were aged over 80 years and 92.6% had morbidities. There was an association between hospitalization and female sex with low and medium vulnerability (64.8%; 95%CI 55.9-72.7 and 63%; 95%CI 53.2-71.8, respectively, with p=0.0262) . Delirium was observed in 29.5% (95%CI 22.3-38.4) of older adults over 60 years of age with low vulnerability, 17% (10.9-25.5) medium, 14.5% ( 8.6-23.9) high, with p=0.0151. There was no association between delirium and the vulnerability index in older adults aged over 80 years, with p=0.235. Delirium affected 44.3% (32.5-56.7) of older adults with low vulnerability, 35% (22.1-50.5) with medium and 25% (12-44.9) high. There was no association between frailty and social vulnerability, with p=0.927. Among older adults aged 80 years or over, frail people prevailed in the three vulnerability strata (low 59.7%; medium 57.5% and high 56%), p=0.788. Conclusion Hospitalization and delirium were associated with younger, pre-frail women from low and medium social vulnerability. The condition of frailty did not correlate with social vulnerability. The need to better understand the biopsychosocial factors that can increase delirium in hospitalized older adults with low social vulnerability is highlighted. Crosssectional Cross sectional Brazil questionnaire Method 30 evaluated 594 59 4 59.4 409 40 9 40.9 8 926 92 6 92.6 morbidities 64.8% 648 64 (64.8% 95CI CI 95 55.972.7 559727 55.9 72.7 55 72 7 55.9-72. 63% 63 53.271.8, 532718 53.2 71.8, 53 2 71 53.2-71.8 respectively p=0.0262 p00262 p 0 0262 295 29 5 29.5 22.338.4 223384 22.3 38.4 22 3 38 22.3-38.4 17 10.925.5 109255 10.9 25.5 10 25 (10.9-25.5 145 14 14.5 8.623.9 86239 8.6 23.9 23 8.6-23.9 p00151 0151 p=0.0151 p0235 235 p=0.235 443 44 44.3 32.556.7 325567 32.5 56.7 32 56 (32.5-56.7 35 22.150.5 221505 22.1 50.5 1 50 (22.1-50.5 1244.9 12449 12 44.9 (12-44.9 p0927 927 p=0.927 59.7% 597 575 57 57.5 56%, 56% , 56%) p0788 788 p=0.788 younger prefrail pre highlighted 59. 40. 92. 64.8 (64.8 972 55.972. 55972 559 55. 727 72. 55.9-72 271 53.271.8 53271 532 53. 718 71.8 53.2-71. p=0.026 p0026 026 29. 338 22.338. 22338 223 22. 384 38. 22.3-38. 925 10.925. 10925 109 10. 255 25. (10.9-25. 14. 623 8.623. 8623 86 8. 239 23. 8.6-23. p0015 015 p=0.015 p023 p=0.23 44. 556 32.556. 32556 325 32. 567 56. (32.5-56. 150 22.150. 22150 221 505 50. (22.1-50. 1244 1244. 449 (12-44. p092 p=0.92 59.7 57. p078 78 p=0.78 64. (64. 97 55.972 5597 55.9-7 27 53.271. 5327 71. 53.2-71 p=0.02 p002 02 33 22.338 2233 22.3-38 10.925 1092 (10.9-25 62 8.623 862 8.6-23 p001 01 p=0.01 p02 p=0.2 32.556 3255 (32.5-56 15 22.150 2215 (22.1-50 124 (12-44 p09 p=0.9 p07 p=0.7 (64 55.97 55.9- 53.271 53.2-7 p=0.0 p00 22.33 22.3-3 10.92 (10.9-2 8.62 8.6-2 p0 p=0. 32.55 (32.5-5 22.15 (22.1-5 (12-4 (6 53.27 53.2- 22.3- (10.9- 8.6- p=0 (32.5- (22.1- (12- (10.9 p= (32.5 (22.1 (12 (10. (32. (22. (1 (10 (32 (22 (3 (2

Resumen Objetivo Analizar la relación entre el índice de vulnerabilidad social y la condición de debilidad física y el delirium en personas mayores hospitalizadas. Métodos Estudio transversal y analítico llevado a cabo con personas mayores en un hospital del sur de Brasil. Se emplearon los siguientes instrumentos para la recopilación: cuestionario sociodemográfico, índice de vulnerabilidad social, marcadores del fenotipo de debilidad física y Confusion Assessement Method. Se utilizó la estadística descriptiva e inferencial. Resultados De las 305 personas mayores evaluadas, el 59,4 % era de sexo femenino, el 40,9 % de más de 80 años y el 92,6 % con morbilidades. Se observó asociación entre hospitalización y sexo femenino con vulnerabilidad baja y mediana (64,8 %; IC95 % 55,9-72,7 y 63 %; IC95 % 53,2-71,8, respectivamente, con p=0,0262). El delirium se observó en el 29,5 % (IC95 % 22,3-38,4) de las personas mayores de más de 60 años con vulnerabilidad baja, el 17 % (10,9-25,5) mediana y el 14,5 % (8,6-23,9) alta, con p=0,0151. No se observó relación entre delirium e índice de vulnerabilidad en personas de más de 80 años, con p=0,235. La incidencia de delirium llegó al 44,3 % (32,5-56,7) de personas mayores con vulnerabilidad baja, 35 % (22,1-50,5) mediana y 25 % (12-44,9) alta. No se observó asociación entre debilidad y vulnerabilidad social, con p=0,927. Entre las personas mayores de 80 años o más, prevalecieron los débiles en las tres categorías de vulnerabilidad (baja 59,7 %; mediana 57,5% y alta 56%), p=0,788. Conclusión La hospitalización y el delirium se asociaron a mujeres más jóvenes, predébiles y con vulnerabilidad social baja y mediana. La condición de debilidad no se correlacionó con la vulnerabilidad social. Se resalta la necesidad de una mejor comprensión de los factores biopsicosociales que pueden aumentar el delirium en personas mayores hospitalizadas con vulnerabilidad social baja. Brasil recopilación sociodemográfico Method inferencial 30 evaluadas 594 59 4 59, 409 40 9 40, 8 926 92 6 92, morbilidades 64,8 648 64 (64, IC IC9 55,972,7 559727 55,9 72,7 55 72 7 55,9-72, 53,271,8, 532718 53,2 71,8, 53 2 71 53,2-71,8 respectivamente p=0,0262. p00262 p p=0,0262 . 0 0262 p=0,0262) 295 29 5 29, (IC9 22,338,4 223384 22,3 38,4 22 3 38 22,3-38,4 1 10,925,5 109255 10,9 25,5 10 (10,9-25,5 145 14 14, 8,623,9 86239 8,6 23,9 23 (8,6-23,9 p00151 0151 p=0,0151 p0235 235 p=0,235 443 44 44, 32,556,7 325567 32,5 56,7 32 56 (32,5-56,7 22,150,5 221505 22,1 50,5 50 (22,1-50,5 1244,9 12449 12 44,9 (12-44,9 p0927 927 p=0,927 597 575 57 57,5 56%, 56% , 56%) p0788 788 p=0,788 jóvenes 64, (64 972 55,972, 55972 559 55, 727 72, 55,9-72 271 53,271,8 53271 532 53, 718 71,8 53,2-71, p0026 p=0,026 026 (IC 338 22,338, 22338 223 22, 384 38, 22,3-38, 925 10,925, 10925 109 10, 255 25, (10,9-25, 623 8,623, 8623 86 8, 239 23, (8,6-23, p0015 015 p=0,015 p023 p=0,23 556 32,556, 32556 325 32, 567 56, (32,5-56, 150 22,150, 22150 221 505 50, (22,1-50, 1244 1244, 449 (12-44, p092 p=0,92 57, p078 78 p=0,78 (6 97 55,972 5597 55,9-7 27 53,271, 5327 71, 53,2-71 p002 p=0,02 02 33 22,338 2233 22,3-38 10,925 1092 (10,9-25 62 8,623 862 (8,6-23 p001 01 p=0,01 p02 p=0,2 32,556 3255 (32,5-56 15 22,150 2215 (22,1-50 124 (12-44 p09 p=0,9 p07 p=0,7 ( 55,97 55,9- 53,271 53,2-7 p00 p=0,0 22,33 22,3-3 10,92 (10,9-2 8,62 (8,6-2 p0 p=0, 32,55 (32,5-5 22,15 (22,1-5 (12-4 53,27 53,2- 22,3- (10,9- (8,6- p=0 (32,5- (22,1- (12- (10,9 (8,6 p= (32,5 (22,1 (12 (10, (8, (32, (22, (1 (10 (8 (32 (22 (3 (2

Resumo Objetivo Identificar evidências de validade da versão brasileira da Post-Discharge Coping Difficulty Scale - Adult Form. Métodos Estudo metodológico desenvolvido por meio das etapas de tradução, retrotradução, avaliação por comitê de especialistas, pré-teste e validação. A validação de conteúdo foi realizada por comitê de seis especialistas, os quais avaliaram as equivalências semântica, idiomática, experimental e conceitual. Para verificar as evidências de validade, a escala foi aplicada a 100 pacientes adultos clínicos e cirúrgicos. Foi realizada a análise de componentes principais, com rotação varimax. A confiabilidade foi verificada por meio do Coeficiente Alfa de Cronbach, quanto à estabilidade, por meio do Teste-Reteste e quanto à equivalência por meio de Confiabilidade Interavaliadores. Verificou-se a validade preditiva da escala em relação à utilização de serviço de emergência e readmissão. Resultados Na avaliação do comitê de especialistas foram realizadas adequações e todos os itens apresentaram um Índice de Validade de Conteúdo superior a 0,80. Na etapa de validação, a análise de componentes principais revelou que a melhor solução seria unifatorial, conforme a escala original. A consistência interna da escala foi satisfatória. A confiabilidade teste-reteste e interavaliadores não mostraram diferença estatística (P > 0,05). Conclusão A versão brasileira da Escala de Dificuldade de Enfrentamento Pós-alta com 10 itens apresenta boas evidências de validade e confiabilidade. Mostrou ser de fácil compreensão pelos participantes e representa uma ferramenta útil para os profissionais e pesquisadores na prática do cuidado. PostDischarge Post Discharge Form tradução retrotradução préteste pré teste semântica idiomática conceitual cirúrgicos varimax Cronbach estabilidade TesteReteste Teste Reteste Interavaliadores Verificouse Verificou se readmissão 080 0 80 0,80 unifatorial original satisfatória testereteste reteste P 0,05. 005 0,05 . 05 0,05) Pósalta Pós alta 1 cuidado 08 8 0,8 00 0,0 0,

Abstract Objective To identify validity evidence of the Brazilian version of the Post-Discharge Coping Difficulty Scale - Adult Form. Methods This methodological study was carried out by means of the stages of translation, back-translation, evaluation by a committee of experts, pre-testing, and validation. Content validation was carried out by a committee of six experts, who evaluated semantic, idiomatic, experimental, and conceptual equivalence. To verify validity evidence, the scale was applied to 100 adult clinical and surgical patients. Principal component analysis was carried out with varimax rotation. Reliability was checked using Cronbach’s alpha, stability using test-retest, and equivalence using inter-rater reliability. The scale’s predictive validity was verified in relation to emergency service use and readmission. Results In the expert committee’s assessment, adjustments were made, and all the items obtained a Content Validity Index higher than 0.80. In the validation stage, the principal component analysis revealed that the best solution would be unifactorial, according to the original scale. The scale’s internal consistency was satisfactory. Test-retest and inter-rater reliability showed no statistical difference (P > 0.05). Conclusion The Brazilian version of the 10-item Post-Discharge Coping Difficulty Scale shows good evidence of validity and reliability. It proved to be easy to understand by the participants and represents a useful tool for professionals and researchers in the practice of care. PostDischarge Post Discharge Form translation backtranslation, backtranslation back back-translation experts pretesting, pretesting pre testing, testing pre-testing semantic idiomatic experimental 10 patients rotation Cronbachs Cronbach s alpha testretest, testretest test retest, retest test-retest interrater inter rater scales readmission committees assessment made 080 0 80 0.80 stage unifactorial satisfactory Testretest Test P 0.05. 005 0.05 . 05 0.05) 10item item care 1 08 8 0.8 00 0.0 0.

Resumen Objetivo Identificar las evidencias de validez de la versión brasileña de la Post-Discharge Coping Difficulty Scale - Adult Form. Métodos Estudio metodológico llevado a cabo mediante las etapas de traducción, retrotraducción, revisión por comité de especialistas, prueba piloto y validación. La validación de contenido se realizó por un comité de seis especialistas, que evaluaron las equivalencias semánticas, idiomáticas, experimentales y conceptuales. Se aplicó la escala a 100 pacientes adultos clínicos y quirúrgicos para verificar las evidencias de validez. Se realizó el análisis de los componentes principales con rotación varimax. La fiabilidad se verificó mediante el coeficiente Alfa de Cronbach, la estabilidad con el test-retest y la equivalencia mediante la fiabilidad entre evaluadores. Se verificó la validez predictiva de la escala con relación a la utilización del servicio de emergencia y readmisión. Resultados Se realizaron adaptaciones en la etapa de revisión del comité de especialistas, y todos los ítems presentaron un índice de validez de contenido superior a 0,80. En la etapa de validación, el análisis de los componentes principales reveló que la mejor solución era unifactorial, según la escala original. La consistencia interna de la escala fue satisfactoria. La fiabilidad test-retest y entre evaluadores no mostraron diferencia estadística (P > 0,05). Conclusión La versión brasileña de la Escala de Dificultad de Enfrentamiento Posalta, que tiene 10 ítems, presenta buenas evidencias de validez y fiabilidad. Demostró ser de fácil comprensión por parte de los participantes y representa una herramienta útil para los profesionales e investigadores de la práctica del cuidado. PostDischarge Post Discharge Form traducción retrotraducción especialistas semánticas idiomáticas conceptuales varimax Cronbach testretest test retest readmisión 080 0 80 0,80 unifactorial original satisfactoria P 0,05. 005 0,05 . 05 0,05) Posalta 1 cuidado 08 8 0,8 00 0,0 0,

Resumo Objetivo Analisar a produção científica acerca da aplicação do Practical Approach to Care Kit Adulto no processo de trabalho do enfermeiro na Atenção Primária à Saúde. Métodos Revisão sistemática realizada nas bases de dados PubMed®, EMBASE, Scopus, Web of Science, Medline® e Cinahl em 17 de julho de 2023. Foram incluídos artigos que evidenciam o uso do Practical Approach to Care Kit Adulto no processo de trabalho de enfermeiros da Atenção Primária à Saúde, em países onde essa tecnologia foi implementada, no formato de estudos originais, relato de caso, artigos de opinião e revisão. Foram excluídos os artigos que tratavam das versões antigas do Practical Approach to Care Kit ou não detalham a forma de uso da tecnologia; se caracterizavam como editoriais, comentários, notícias, resumos de congressos, protocolos de pesquisa, teses e dissertações ou estavam indisponíveis na íntegra. A análise do risco de viés dos estudos foi realizada em dupla, utilizando os checklists do Joanna Briggs Institute para estudos qualitativos, de opinião e ensaios clínicos randomizados. Resultados Foram selecionados seis artigos que evidenciaram o uso do Practical Approach to Care Kit enquanto uma tecnologia de apoio à tomada de decisão clínica do enfermeiro. Também se destacou sua aplicação em ações de educação permanente da equipe nos serviços de Atenção Primária à Saúde. Conclusão Esta revisão contribui com o campo de conhecimento de enfermagem em saúde pública ao evidenciar o uso de uma tecnologia inovadora e de baixo custo no processo de cuidado dos enfermeiros. Saúde PubMed PubMed® EMBASE Scopus Science Medline 1 2023 implementada originais caso editoriais comentários notícias congressos pesquisa íntegra dupla qualitativos randomizados 202 20 2

Abstract Objective To analyze scientific production about the Practical Approach to Care Kit Adult application in nurses’ work process in Primary Health Care. Methods A systematic review carried out in the PubMed®, EMBASE, Scopus, Web of Science, MEDLINE® and CINAHL databases on July 17, 2023. Articles were included that demonstrate the Practical Approach to Care Kit Adult use in nurses’ work process in Primary Health Care, in countries where this technology has been implemented in the format of original studies, case reports, opinion articles and reviews. Articles that dealt with old versions of the Practical Approach to Care Kit or did not detail how the technology was used, were characterized as editorials, comments, news, conference abstracts, research protocols, theses and dissertations or were unavailable in full were excluded. The analysis of the risk of bias of studies was carried out in pairs, using the JBI checklists for qualitative studies, opinion and randomized clinical trials. Results Six articles were selected that highlighted the Practical Approach to Care Kit use as a technology to support nurses’ clinical decision-making. Its application in permanent education actions of the teams in Primary Health Care services also stood out. Conclusion This review contributes to public health nursing knowledge by highlighting the use of an innovative and low-cost technology in nurses’ care process. nurses PubMed PubMed® EMBASE Scopus Science MEDLINE 17 2023 reports reviews used editorials comments news abstracts protocols excluded pairs trials decisionmaking. decisionmaking decision making. making decision-making lowcost low cost 1 202 20 2

Resumen Objetivo Analizar la producción científica sobre la aplicación del Practical Approach to Care Kit adulto en el proceso de trabajo de enfermeros de la Atención Primaria de Salud. Métodos Revisión sistemática realizada en las bases de datos PubMed®, EMBASE, Scopus, Web of Science, Medline® y Cinahl el 17 de julio de 2023. Se incluyeron artículos que demostraron el uso del Practical Approach to Care Kit adulto en el proceso de trabajo de enfermeros de la Atención Primaria de Salud, en países donde se implementó esta tecnología, en formato de estudios originales, relatos de caso, artículos de opinión y revisión. Se excluyeron los artículos que utilizaron versiones anteriores del Practical Approach to Care Kit o no detallaron la forma de uso de la tecnología, se caracterizaron como editoriales, comentarios, noticias, resúmenes de congresos, protocolos de investigación, tesis de doctorado y de maestría o los que no estaban disponibles en su totalidad. El análisis de riesgo de sesgo de los estudios se realizó en pares, utilizando las checklists del Joanna Briggs Institute para estudios cualitativos, de opinión y ensayos clínicos aleatorizados. Resultados Se seleccionaron seis artículos que demostraron el uso del Practical Approach to Care Kit como una tecnología de soporte a la toma de decisiones clínicas de los enfermeros. También se destacó su aplicación en acciones de educación permanente del equipo de los servicios de Atención Primaria de Salud. Conclusión Esta revisión contribuye con el campo de conocimiento de enfermería en salud pública porque demuestra el uso de una tecnología innovadora y de bajo costo en el proceso de cuidado de los enfermeros. Open Science Framework: 10.17605/OSF.IO/J3TZ6 Salud PubMed PubMed® EMBASE Scopus Medline 1 2023 originales caso editoriales comentarios noticias congresos investigación totalidad pares cualitativos aleatorizados Framework 1017605OSFIOJ3TZ6 OSFIOJTZ 10 17605 OSF IO J3TZ6 J TZ 10.17605/OSF.IO/J3TZ 202 OSFIOJ 1017605OSFIOJ3TZ 1760 JTZ J3TZ 20 176 2

ABSTRACT Purpose: This study aimed to characterize retinitis pigmentosa associated with the eyes shut homolog gene, which causes hereditary retinal degeneration. Methods: The anatomical and functional findings of retinitis pigmentosa in patients with variants of the eyes shut homolog gene were characterized and compared using multimodal imaging and genetic analysis of the variants. Clinical data such as visual acuity, lens status, and refraction were obtained from medical records. Patients underwent an ophthalmic examination, including static visual field, microperimetry, optical coherence tomography, fundus autofluorescence, and fundus photography. Results: Twenty-two patients were included in the study. Several anatomical and functional characteristics of retinitis pigmentosa-eyes shut homolog were identified, including the presence of cataracts, cystoid macular edema, epiretinal membrane, and a tubular visual field. Genetic results revealed 26 distinct variants in the cohort, with 7 novel variants not previously documented or reported in the scientific literature or databases. Conclusion: The findings demonstrate that eyes shut homolog-retinitis pigmentosa manifests in specific patterns, starting in adolescence with mild progression and advancing with age. The integration of multimodal imaging and genetic analysis has provided a detailed understanding of the anatomical and functional features of retinitis pigmentosa-eyes shut homolog. Seven novel variants of the eyes shut homolog gene have been identified. These findings enhance the understanding of eyes shut homolog-related retinitis pigmentosa characteristics of by detailing the spectrum of mutations in this gene within the Brazilian population. Purpose degeneration Methods acuity status records examination field microperimetry tomography autofluorescence photography Results Twentytwo Twenty two pigmentosaeyes identified cataracts edema membrane 2 cohort databases Conclusion homologretinitis patterns age homologrelated related population

ABSTRACT Chia (Salvia hispanica L.) seeds have attracted great economic interest for their high levels of linoleic and α-linolenic acids. In Brazil, there is a lack of studies on the agronomic characteristics and physiological quality of chia, necessitating research on germination processes and strategies to enhance yield under field conditions. There are no studies assessing the development of seeds with different coat colors in the presence of fungicides. This study aimed to assess the physiological quality of chia seeds as a function of coat color and fungicide treatment. The experiment followed a completely randomized design with a 2 × 2 factorial arrangement and six replications. For this, seeds were divided into two groups according to coat color (black and white) and subjected or not to treatment with carboxin + thiram. Germination speed index, germination rate, and shoot length were evaluated in plants sown at 0, 90, and 180 days after seed treatment. Germination rate and speed index differed significantly between coat colors, with white seeds having higher vigor than black seeds. Shoot length, however, differed only for seeds sown on the day of treatment, indicating that treated seeds were more vigorous. Salvia L. L αlinolenic α linolenic acids Brazil conditions fungicides replications this thiram 0 90 18 however vigorous 9 1

Food contamination is a public health problem, and the search for natural additives to increase food stability and safety is challenging. This research aimed to study nanoemulsions produced with coriander essential oil and kefiran, an exopolysaccharide extracted from kefir grains. The composition of coriander essential oil was evaluated, revealing linalool as the main component. An experimental design consisting of six trials was conducted. The NE2 formulation (0.5% kefiran and 1.5% coriander essential oil) exhibited smaller particle size, monodispersity, a lower centrifugal stability coefficient, and higher absolute zeta potential values (> 30 mV), indicating high electrical stability. Morphology, thermal stability, and toxicity tests were performed. The minimum bactericidal concentration was determined and applied to commercial cheese. Thermal stability tests demonstrated an increase in the stability of NE2 compared to its individual components, and it was also proven to be non-toxic. The concentration of 25% m v-1 was identified as the minimum bactericidal concentration and was applied to commercial cheese. problem challenging grains evaluated component conducted NE 0.5% 05 0 5 (0.5 15 1 1.5 size monodispersity coefficient > ( 3 mV, mV , mV) Morphology performed cheese components nontoxic. nontoxic non toxic. toxic non-toxic 25 v1 v v- 0.5 (0. 1. 2 0. (0

São apresentadas reflexões sobre a relevância histórica dos bufões por meio de uma análise sobre a visão artística e social do bufão ao palhaço de hospital. É discutida em quatro tópicos: A máscara, o ator e a plateia; O bufão e a expressão do ridículo; O espetáculo e a indicação do ridículo; e O riso na sociedade do espetáculo. O palhaço de hospital favorece reflexões semelhantes às do bufão, mas é necessário que a interação com o público apresente um espetáculo de comicidade com postura ética. Tem a capacidade de rir de si mesmo perante as adversidades e enfermidades, sempre com o devido respeito ao doente. E não somente isso: o palhaço de hospital consegue, através de posturas muitas vezes caricatas, inverter e questionar a lógica do poder do ambiente de saúde, fazendo disso um profissionalismo e protagonismo dele nesse espaço. tópicos máscara plateia ridículo ética enfermidades doente isso consegue caricatas saúde espaço

The study presents reflections on the historical relevance of buffoons through an analysis of the artistic and social view from the buffoon to the hospital clown. The subject is discussed in four topics: The mask, the actor, and the audience; The buffoon and the expression of ridicule; The spectacle and the indication of ridicule; and Laughter in the society of the spectacle. The hospital clown promotes a reflection that is similar to that of the buffoon, but the interaction with the audience must present a spectacle of comicality with an ethical stance. It is possible to laugh at oneself in the face of adversity, at the sick body, but respecting the patient, and at postures of professional superiority concerning care, as a way of reversing the logic of power without questioning one’s professionalism, with an equal degree of protagonism. topics mask actor ridicule stance adversity body patient care ones one s professionalism protagonism

Se presentan reflexiones sobre la relevancia histórica de los bufones, por medio de un análisis sobre la visión artística y social del bufón al payaso de hospital. Se discute en 4 tópicos: la máscara, el actor y el público; El Bufón y la expresión del ridículo; El espectáculo y la indicación del ridículo y La risa en la sociedad del espectáculo. El payaso de hospital favorece reflexiones semejantes a las del Bufón, pero es necesario que la interacción con el público presente un espectáculo de comicidad con postura ética. Es posible reírse de uno mismo ante las adversidades; del cuerpo enfermo, pero con respeto al enfermo; de las posturas de superioridad profesional ante la asistencia, como una forma de invertir la lógica del poder y sin poner en tela de juicio su profesionalismo, con el mismo grado de protagonismo. bufones tópicos máscara ética adversidades enfermo asistencia profesionalismo protagonismo