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ABSTRACT Purpose: This study aimed to characterize retinitis pigmentosa associated with the eyes shut homolog gene, which causes hereditary retinal degeneration. Methods: The anatomical and functional findings of retinitis pigmentosa in patients with variants of the eyes shut homolog gene were characterized and compared using multimodal imaging and genetic analysis of the variants. Clinical data such as visual acuity, lens status, and refraction were obtained from medical records. Patients underwent an ophthalmic examination, including static visual field, microperimetry, optical coherence tomography, fundus autofluorescence, and fundus photography. Results: Twenty-two patients were included in the study. Several anatomical and functional characteristics of retinitis pigmentosa-eyes shut homolog were identified, including the presence of cataracts, cystoid macular edema, epiretinal membrane, and a tubular visual field. Genetic results revealed 26 distinct variants in the cohort, with 7 novel variants not previously documented or reported in the scientific literature or databases. Conclusion: The findings demonstrate that eyes shut homolog-retinitis pigmentosa manifests in specific patterns, starting in adolescence with mild progression and advancing with age. The integration of multimodal imaging and genetic analysis has provided a detailed understanding of the anatomical and functional features of retinitis pigmentosa-eyes shut homolog. Seven novel variants of the eyes shut homolog gene have been identified. These findings enhance the understanding of eyes shut homolog-related retinitis pigmentosa characteristics of by detailing the spectrum of mutations in this gene within the Brazilian population. Purpose degeneration Methods acuity status records examination field microperimetry tomography autofluorescence photography Results Twentytwo Twenty two pigmentosaeyes identified cataracts edema membrane 2 cohort databases Conclusion homologretinitis patterns age homologrelated related population

https://doi.org/10.5935/0004-2749.2024-0104

Fiber consumption mediates the association between family meals and obesity in Brazilian adolescents
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da Silva, Juliana Ilídio

; de Souza Andrade, Amanda Cristina

; Vergetti-Bloch, Katia

; Soares-Brunken, Gisela

Revista chilena de nutrición

Journal Metrics
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aug 2024, Volume 51 N. 4 Pages 263 - 272

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Objective: This study evaluates the association between fiber intake and obesity in Brazilian adolescents, according to sex and having meals with parents/guardians. Methods: We used data from the Study on Cardiovascular Risks in Adolescents (ERICA) (12-17 years), a cross-sectional study conducted between 2013 and 2014 in all cities with more than 100,000 inhabitants. Obesity was classified based on World Health Organization criteria for BMI. Fiber intake was obtained from a 24-hour dietary recall, and the following values were considered adequate: for males, ≥25g/day (aged 9-13 years) and ≥31g/day (aged 14-17 years); for females, ≥22g/day (aged 9-13 years) and ≥25g/day (aged 14-17 years). The categories for lunch and dinner with parents/guardians were “never/rarely/sometimes” versus “every day/almost every day”. Poisson regression models were used to examine the associations between obesity and fiber intake adjusted for covariates and stratified by sex and meals. Results: 69,627 adolescents were evaluated, 50.2% male and mean age 14.4 years (SD=1,6). A lower prevalence of obesity was observed in adolescents with adequate fiber intake who had lunch “every day/almost every day” (females: PR=0.51; 95%CI: 0.36-0.72; males: PR=0.59; 95%CI: 0.42-0.82) and dinner with their parents/guardians (females: PR=0.48; 95%CI: 0.35-0.65; males: PR=0.58; 95%CI: 0.42-0.78). Conclusion: Adolescents who frequently had meals with their parents/guardians and reported adequate fiber consumption had a lower prevalence of obesity.

Resumen Objetivo: Este estudio tiene como objetivo evaluar la asociación entre el consumo de fibra y la obesidad en adolescentes brasileños, según el sexo y la frecuencia de las comidas con padres/tutores. Métodos: Se utilizaron datos del Estudio de Riesgos Cardiovasculares en Adolescentes (ERICA) (12-17 años), un estudio transversal realizado entre 2013 y 2014 en todas las ciudades con más de 100.000 habitantes. La obesidad se clasificó según los criterios de IMC de la Organización Mundial de la Salud. La ingesta de fibra se obtuvo a partir de un recordatorio dietético de 24 horas, y se consideraron valores adecuados los siguientes: para varones de 9 a 13 años, ≥25 g/día y de 14 a 17 años, ≥31 g/día; para mujeres de 9 a 13 años, ≥22 g/día y de 14 a 17 años, ≥25 g/día. Las categorías para el almuerzo y la cena con padres/tutores fueron: “nunca/rara vez/a veces” vs. “todos los días/casi todos los días”. Se utilizaron modelos de regresión de Poisson para examinar las asociaciones entre la obesidad y la ingesta de fibra, ajustadas por covariables y estratificadas por sexo y comidas. Resultados: Se evaluaron 69.627 adolescentes, 50,2% varones, con una edad media de 14,4 años (DE=1,6). Se observó una menor prevalencia de obesidad en los adolescentes con una ingesta adecuada de fibra y que almorzaban “todos los días/casi todos los días” (mujeres: PR=0,51; IC95%: 0,36-0,72; varones: PR=0,59; IC95%: 0,42-0,82) y cenaban con sus padres/tutores (mujeres: PR=0,48; IC95%: 0,35-0,65; varones: PR=0,58; IC95%: 0,42-0,78). Conclusión: Los adolescentes que comían frecuentemente con sus padres/tutores y reportaban un consumo adecuado de fibra tenían una menor prevalencia de obesidad.

https://doi.org/10.4067/s0717-75182024000400263

Integration of physicochemical and instrumental quality data to estimate the texture of polished rice
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Bento, Juliana Aparecida Correia

; Silva, Marília Araújo

; Rosário Neto, Antônio

; Souza Neto, Menandes Alves de

; Narciso, Marcelo Gonçalves

; Colombari Filho, José Manoel

; Bassinello, Priscila Zaczuk

Ciência Rural

Journal Metrics
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jul 2024, Volume 54 N. 7 elocation e20230327

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Este trabalho avaliou diferentes genótipos de arroz quanto a parâmetros físico-químicos e instrumentais de qualidade do grão e associou os dados à análise sensorial para subsidiar a criação de regras de classificação da qualidade culinária do arroz (textura), com base em parâmetros isolados ou combinados. A combinação do teor de amilose e temperatura de gelatinização foi capaz de predizer a qualidade do arroz. De acordo com o painel sensorial, a pegajosidade instrumental foi capaz de segregar arroz com baixo teor de amilose ou ceroso dos demais. Em relação às propriedades de pasta, o arroz que apresentou alta viscosidade final (310-480RVU), retrogradação (165-245RVU) e temperatura de pasta (78-88 °C) e baixos valores de quebra pasta (15-120RVU), associados a uma alta pegajosidade (> -5N) será desejável pelos consumidores brasileiros. As regras de classificação criadas por meio da relação entre os parâmetros físico-químicos e o perfil de textura avaliado pelo painel sensorial ajudarão a verificar o perfil culinário das amostras de arroz (por meio de um software livre), o que torna mais fácil prever a probabilidade de o arroz atender aos padrões de qualidade desejados. RESUMO físicoquímicos físico químicos textura, , (textura) combinados demais 310480RVU, 310480RVU RVU 310 480RVU (310-480RVU) 165245RVU 165 245RVU (165-245RVU 7888 78 88 (78-8 °C C 15120RVU, 15120RVU 15 120RVU (15-120RVU) > ( 5N N -5N brasileiros livre, livre livre) desejados (textura 31 (310-480RVU 16 788 7 8 (78- 1 (15-120RVU 3 (78 (7

ABSTRACT: This research evaluated different rice genotypes regarding physicochemical and instrumental parameters of grain quality and associated the data with sensory analysis to support the creation of rules for classification of the culinary quality of rice (texture), based on isolated or combined parameters. The combination of amylose content and gelatinization temperature was able to predict the rice quality. According to the sensorial panel, the instrumental stickiness was able to segregate rice with very low amylose content or waxy to the other ones. Regarding pasting properties, rice that presented high final viscosity (310-480 RVU), setback (165-245 RVU), and pasting temperature (78 - 88 °C), and low values for breakdown (15-120 RVU), associated with a high stickiness (>-5N) was desirable by the Brazilian consumers. The classification rules created through the relationship between the physicochemical parameters and the texture profile evaluated by the sensory panel will help to verify the culinary profile of the rice samples (through free software), which makes it easier to predict the probability of rice meeting the desired quality standards. ABSTRACT texture, , (texture) ones properties 310480 310 480 (310-48 RVU, RVU RVU) 165245 165 245 (165-24 78 (7 8 °C, C °C °C) 15120 15 120 (15-12 >5N 5N N > (>-5N consumers software, software software) standards (texture 31048 31 48 (310-4 16524 16 24 (165-2 7 ( 1512 1 12 (15-1 3104 3 4 (310- 1652 2 (165- 151 (15- (310 (165 (15 (31 (16 (1 (3

https://doi.org/10.1590/0103-8478cr20230327

Correlação entre o índice de resistência vascular e a arteriografia na avaliação do leito arterial distal na isquemia crítica dos membros inferiores
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Buril, Gabriela de Oliveira

; Lins, Esdras Marques

; Silva, Emmanuelle Tenório Albuquerque Godoi Berenguer de Barros e

; Rocha, Fernanda Appolônio da

; Charamba, Juliana Cavalcanti de Siqueira

; Caldas, Rebecca Paes de Andrade Souza

; Vieira, Isadora Ísis Fernandes

; Silva, Paloma Karine Araújo da

Jornal Vascular Brasileiro

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2024, Volume 23 elocation e20230071

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Contexto Pacientes com isquemia crítica (IC) dos membros inferiores (MMII) precisam de arteriografia para o planejamento da cirurgia de revascularização. A ultrassonografia Doppler (UD) não é invasiva e, através da aferição do índice de resistência (IR), pode fornecer informações sobre as artérias distais. Objetivos Correlacionar a Classificação Angiográfica de Rutherford com o IR na avaliação do leito arterial distal dos MMII. Métodos Estudo transversal, realizado em hospital público terciário, com 120 pacientes portadores de IC dos MMII, entre setembro de 2019 a abril de 2022. Foi comparado o IR das artérias da perna passíveis de serem receptoras de revascularização com a imagem obtida através da arteriografia dessas artérias em acordo com a Classificação Angiográfica de leito distal de Rutherford. Resultados Foram avaliados 120 MMII em 120 pacientes com idade média de 68,6 anos. A amostra foi composta de 50,0% de pacientes do sexo masculino. Na amostra, 90,0% pacientes encontravam-se na classe cinco de Rutherford. Os valores do IR encontrados para as artérias de perna apresentaram uma correlação positiva, estatisticamente significativa, quando comparados com a Classificação de Rutherford (tibial anterior, p< 0,01; tibial posterior, p = 0,012 e fibular, p = 0,034 e artéria dorsal do pé, p < 0,001). Conclusões Neste estudo, os IRs das artérias da perna obtidos através da ultrassonografia Doppler apresentaram uma correlação positiva quando comparados à classificação de Rutherford. Em pacientes com isquemia crítica, esse índice pode ser útil na avaliação do leito arterial distal dos membros inferiores. (IC (MMII UD (UD IR, , (IR) distais transversal terciário 12 201 2022 686 68 6 68, anos 500 50 0 50,0 masculino 900 90 90,0 encontravamse encontravam se significativa anterior 0,01 001 01 posterior 0012 012 fibular 0034 034 0,03 pé 0,001. 0001 0,001 . 0,001) estudo (IR 1 20 202 5 50, 9 90, 0,0 00 003 03 000 0,00 2 0,

Abstract Background Patients with chronic limb threatening ischemia (CLTI) of the lower limbs (LL) undergo arteriography for revascularization surgery planning. Doppler ultrasound (DU) is non-invasive and can provide information about the distal arteries through measurement of the resistance index (RI). Objectives To correlate the Rutherford Angiographic Classification with the RI for assessment of the distal arterial bed of the LL. Methods A cross-sectional study, conducted at a public tertiary hospital with 120 patients with LL CLTI, from September 2019 to April 2022. The RI of arteries that were candidates for revascularization was compared with the images of the same arteries obtained using arteriography, using the Rutherford Angiographic Classification of the distal bed. Results A total of 120 LL were assessed in 120 patients with a mean age of 68.6 years. The sample was 50.0% male and 90.0% of the patients in the sample were classified as Rutherford category five. The RI values found for the arteries of the leg exhibited a statistically significant positive correlation with the Rutherford Classification (anterior tibial, p< 0.01; posterior tibial, p = 0.012 fibular, p = 0.034; and dorsalis pedis, p < 0.001). Conclusions In this study, RIs for the arteries of the leg measured using Doppler ultrasound exhibited a positive correlation with the Rutherford Classification. This index could be useful for assessment of the distal arterial bed of the lower limbs of patients with chronic limb threatening ischemia. CLTI (CLTI (LL planning DU (DU noninvasive non invasive RI. . (RI) crosssectional cross sectional study 12 201 2022 686 68 6 68. years 500 50 0 50.0 900 90 90.0 five anterior tibial 0.01 001 01 0012 012 fibular 0.034 0034 034 pedis 0.001. 0001 0.001 0.001) (RI 1 20 202 5 50. 9 90. 0.0 00 0.03 003 03 000 0.00 2 0.

https://doi.org/10.1590/1677-5449.202300711

Egg quality and performance of Japanese quail supplemented with organic and inorganic selenium
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TORGA, Anderson de Paula

; TEIXEIRA, Alexandre de Oliveira

; REIS, Renata de Souza

; MOREIRA, Leonardo Marmo

; SOUSA, Júlio César Melo de

; MORAES, Monique Silva de

; LACERDA, Alicia Beatriz Ferreira de

; LYON, Juliana Pereira

; ROCHA JUNIOR, Carlos Magno da

Revista Brasileira de Saúde e Produção Animal

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2024, Volume 25 elocation e20230027

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivou-se avaliar a suplementação de selênio orgânico (Se org.) em diferentes concentrações e de selênio inorgânico (Se inorg.) nas rações de codornas sobre o desempenho; qualidade dos ovos; e tempo e condições de armazenamento. No ensaio de desempenho foram utilizadas 360 codornas com 27 semanas de idade, distribuídas em delineamento inteiramente casualizado (DIC) composto por seis tratamentos: Ração Basal; 0,15; 0,30; 0,45; e 0,60 ppm de Se org. e 0,60 ppm de Se inorg. suplementados on top à ração basal, com seis repetições e dez aves por unidade experimental. Para avaliar o tempo e condições de armazenamento foram utilizados 720 ovos de codornas distribuídos em DIC, com esquema fatorial 6x5x2 (sendo seis tratamentos provenientes do ensaio de desempenho; cinco tempos de estocagem (7, 14, 21, 28 e 35 dias); e duas formas de estocagem (refrigerada e não refrigerada), com doze repetições contendo um ovo cada. Não houve efeito na suplementação de Se org. e Se inorg. nas rações sobre desempenho e qualidade dos ovos. Houve aumento linear na concentração de Se nos ovos de codornas alimentadas com níveis crescentes deste nutriente. Houve efeito da suplementação com selênio sobre o tempo de estocagem na qualidade de ovos mantidos sob refrigeração e em temperatura ambiente. Conclui-se que a suplementação, on top, de níveis entre 0,15 e 0,60 ppm de selênio nas formas orgânica ou inorgânica, não altera o desempenho das codornas, acentuando, contudo, a deposição desse mineral nos ovos, favorecendo a manutenção da qualidade ao longo do tempo de armazenamento. Objetivouse Objetivou se org inorg 36 2 idade DIC (DIC Basal 015 0 15 0,30 030 30 0,45 045 45 060 60 0,6 basal experimental 72 xx x 6x5x sendo 7, 7 (7 14 21 3 dias dias) refrigerada refrigerada, , refrigerada) cada nutriente ambiente Concluise Conclui 0,1 inorgânica acentuando contudo 01 1 0,3 03 0,4 04 4 06 6 0, (

ABSTRACT The objective of this study was to assess the impact of supplementing quail diets with organic selenium (Se) at various concentrations and inorganic Se on performance, egg quality, and storage time under different conditions. In the performance trial, 360 quail aged 27 weeks were included in a completely randomized design comprising six treatments: Basal Diet; 0.15, 0.30, 0.45, and 0.60 ppm of organic Se; and 0.60 ppm of inorganic Se, supplemented “on top” of the basal diet. Six replications were used, each with 10 birds per experimental unit. For the evaluation of storage time and conditions, 720 quail eggs were employed in a completely randomized design. The design featured a 6×5×2 factorial arrangement consisting of six treatments derived from the performance trial, five storage times (7, 14, 21, 28, and 35 days), and two storage forms (refrigerated and non-refrigerated). Each replication contained one egg, totaling 12 replications. Results indicated no significant effect of organic or inorganic Se supplementation in the diets on performance or egg quality. However, Se concentration increased linearly in eggs from quail fed increasing levels of this nutrient. Selenium supplementation affected storage time and egg quality under refrigerated and room-temperature conditions. In conclusion, on-top Se supplementation at concentrations ranging from 0.15 to 0.60 ppm, whether in organic or inorganic forms, does not impact quail performance. Nevertheless, it leads to increased Se deposition in eggs, contributing to the maintenance of egg quality throughout the storage period. (Se conditions trial 36 2 Diet 015 0 15 030 30 0.30 045 45 0.45 060 60 0.6 top diet used 1 unit 72 652 6 5 6×5× 7, 7 (7 14 21 28 3 days, days , days) nonrefrigerated. nonrefrigerated non . non-refrigerated) However nutrient roomtemperature room temperature conclusion ontop 0.1 Nevertheless period 01 03 0.3 04 4 0.4 06 0. 65 6×5 ( non-refrigerated 6×

https://doi.org/10.1590/s1519-994020230027

Family characteristics and loneliness among older adults: evidence from the Brazilian Longitudinal Study of Aging (ELSI-Brazil)
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Marcelino, Karla Geovani Silva

; Braga, Luciana de Souza

; Lima-Costa, Maria Fernanda

; Torres, Juliana Lustosa

Revista Brasileira de Epidemiologia

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2024, Volume 27 elocation e240054

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Examinar associação entre as características da família relativas ao cônjuge e aos(às) filhos(as) e a solidão em brasileiros com 50 anos e mais, considerando a ocorrência de solidão e seus níveis. Métodos: Estudo transversal, com dados de 7.163 participantes da segunda onda do Estudo Longitudinal da Saúde dos Idosos Brasileiros, um estudo nacionalmente representativo conduzido entre 2019–2021. Solidão foi mensurada por meio da escala de solidão da Universidade da Califórnia de três itens. As características da família consideraram: situação conjugal e moradia com cônjuge e presença de filhos(as) e moradia com eles. A análise estatística foi baseada em modelos de regressão do tipo zero-inflated negative binomial, um método estatístico que permite avaliar o desfecho de maneira dicotômica e como contagem. Resultados: Apenas as características da família relativas ao cônjuge se associaram à prevalência de solidão, independentemente de o cônjuge viver em outro domicílio (razão de prevalência — RP=0,35; intervalo de confiança de 95% — IC95% 0,23–0,53) ou no mesmo (RP=0,37; IC95% 0,30–0,45). Características familiares relativas ao cônjuge [cônjuge vivendo no mesmo domicílio (RP=0,80; IC95% 0,73–0,88)] e aos filhos [filhos vivendo em outro domicílio (RP=0,86; IC95% 0,77–0,95) ou no mesmo (RP=0,81; IC95% 0,72–0,92)] se associaram negativamente ao nível de solidão. Conclusão: As características da família contribuem para prevenir a solidão e para reduzir seus níveis. Serviços públicos de prestação de apoio social devem priorizar adultos mais velhos com núcleos familiares reduzidos.

ABSTRACT Objective: To investigate the association between family characteristics concerning partners and children and loneliness among Brazilians aged 50 and over, taking into account both the occurrence of loneliness and its severity levels. Methods: This cross-sectional study used data from 7,163 participants in the second wave of the Brazilian Longitudinal Study of Aging, a nationally representative study conducted in 2019-2021. Loneliness was assessed using the 3-item University of California Loneliness Scale. Family characteristics included: marital status and living with the partner and presence of children and living with them. Statistical analysis employed Zero-Inflated Negative Binomial regression models, allowing the assessment of the outcome in both dichotomous and counting-based forms. Results: Only family characteristics related to the partner were associated with loneliness prevalence, whether in a living-apart-together arrangement (PR=0.35; 95%CI 0.23–0.53) or cohabiting (PR=0.37; 95%CI 0.30–0.45). Family characteristics concerning the partner [cohabiting (PR=0.80; 95% CI 0.73–0.88)] and children [non-cohabiting (PR=0.86; 95%CI 0.77–0.95) or cohabiting (PR=0.81; 95%CI 0.72–0,92)] were negatively associated with loneliness levels. Conclusion: Family characteristics play a crucial role in both preventing loneliness and reducing its levels. Public services for improving social support should target older adults with reduced nuclear families.

https://doi.org/10.1590/1980-549720240054

Prospective, randomized, controlled trial assessing the effects of a driving pressure–limiting strategy for patients with acute respiratory distress syndrome due to community-acquired pneumonia (STAMINA trial): protocol and statistical analysis plan Prospective randomized pressurelimiting pressure limiting communityacquired community acquired STAMINA trial)
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Maia, Israel Silva

; Medrado Jr, Fernando Azevedo

; Tramujas, Lucas

; Tomazini, Bruno Martins

; Oliveira, Júlia Souza

; Sady, Erica Regina Ribeiro

; Barbante, Letícia Galvão

; Nicola, Marina Lazzari

; Gurgel, Rodrigo Magalhães

; Damiani, Lucas Petri

; Negrelli, Karina Leal

; Miranda, Tamiris Abait

; Santucci, Eliana

; Valeis, Nanci

; Laranjeira, Ligia Nasi

; Westphal, Glauco Adrieno

; Fernandes, Ruthy Perotto

; Zandonai, Cássio Luis

; Pincelli, Mariangela Pimentel

; Figueiredo, Rodrigo Cruvinel

; Bustamante, Cíntia Loss Sartori

; Norbin, Luiz Fernando

; Boschi, Emerson

; Lessa, Rafael

; Romano, Marcelo Pereira

; Miura, Mieko Cláudia

; Alencar Filho, Meton Soares de

; Dantas, Vicente Cés de Souza

; Barreto, Priscilla Alves

; Hernandes, Mauro Esteves

; Grion, Cintia Magalhães Carvalho

; Laranjeira, Alexandre Sanches

; Mezzaroba, Ana Luiza

; Bahl, Marina

; Starke, Ana Carolina

; Biondi, Rodrigo Santos

; Dal-Pizzol, Felipe

; Caser, Eliana Bernadete

; Thompson, Marlus Muri

; Padial, Andrea Allegrini

; Veiga, Viviane Cordeiro

; Leite, Rodrigo Thot

; Araújo, Gustavo

; Guimarães, Mário

; Martins, Priscilla de Aquino

; Lacerda, Fábio Holanda

; Hoffmann Filho, Conrado Roberto

; Melro, Livia

; Pacheco, Eduardo

; Ospina-Táscon, Gustavo Adolfo

; Ferreira, Juliana Carvalho

; Freires, Fabricio Jocundo Calado

; Machado, Flávia Ribeiro

; Cavalcanti, Alexandre Biasi

; Zampieri, Fernando Godinho

Critical Care Science

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2024, Volume 36 elocation e20240210en

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Contexto: Em estudos observacionais sobre a síndrome do desconforto respiratório agudo, sugeriu-se que a driving pressure é o principal fator de lesão pulmonar induzida por ventilador e de mortalidade. Não está claro se uma estratégia de limitação da driving pressure pode melhorar os desfechos clínicos. Objetivo: Descrever o protocolo e o plano de análise estatística que serão usados para testar se uma estratégia de limitação da driving pressure envolvendo a titulação da pressão positiva expiratória final de acordo com a melhor complacência respiratória e a redução do volume corrente é superior a uma estratégia padrão envolvendo o uso da tabela de pressão positiva expiratória final baixa do protocolo ARDSNet, em termos de aumento do número de dias sem ventilador em pacientes com síndrome do desconforto respiratório agudo devido à pneumonia adquirida na comunidade. Métodos: O estudo STAMINA (ventilator STrAtegy for coMmunIty acquired pNeumoniA) é randomizado, multicêntrico e aberto e compara uma estratégia de limitação da driving pressure com a tabela de pressão positiva expiratória final baixa do protocolo ARDSnet em pacientes com síndrome do desconforto respiratório agudo moderada a grave devido à pneumonia adquirida na comunidade internados em unidades de terapia intensiva. Esperamos recrutar 500 pacientes de 20 unidades de terapia intensiva brasileiras e duas colombianas. Eles serão randomizados para um grupo da estratégia de limitação da driving pressure ou para um grupo de estratégia padrão usando a tabela de pressão positiva expiratória final baixa do protocolo ARDSnet. No grupo da estratégia de limitação da driving pressure, a pressão positiva expiratória final será titulada de acordo com a melhor complacência do sistema respiratório. Desfechos: O desfecho primário é o número de dias sem ventilador em 28 dias. Os desfechos secundários são a mortalidade hospitalar e na unidade de terapia intensiva e a necessidade de terapias de resgate, como suporte de vida extracorpóreo, manobras de recrutamento e óxido nítrico inalado. Conclusão: O STAMINA foi projetado para fornecer evidências sobre se uma estratégia de limitação da driving pressure é superior à estratégia da tabela de pressão positiva expiratória final baixa do protocolo ARDSnet para aumentar o número de dias sem ventilador em 28 dias em pacientes com síndrome do desconforto respiratório agudo moderada a grave. Aqui, descrevemos a justificativa, o desenho e o status do estudo. Contexto sugeriuse sugeriu clínicos Objetivo ARDSNet Métodos ventilator pNeumoniA randomizado 50 2 colombianas Desfechos resgate extracorpóreo inalado Conclusão Aqui justificativa 5

ABSTRACT Background: Driving pressure has been suggested to be the main driver of ventilator-induced lung injury and mortality in observational studies of acute respiratory distress syndrome. Whether a driving pressure-limiting strategy can improve clinical outcomes is unclear. Objective: To describe the protocol and statistical analysis plan that will be used to test whether a driving pressure-limiting strategy including positive end-expiratory pressure titration according to the best respiratory compliance and reduction in tidal volume is superior to a standard strategy involving the use of the ARDSNet low-positive end-expiratory pressure table in terms of increasing the number of ventilator-free days in patients with acute respiratory distress syndrome due to community-acquired pneumonia. Methods: The ventilator STrAtegy for coMmunIty acquired pNeumoniA (STAMINA) study is a randomized, multicenter, open-label trial that compares a driving pressure-limiting strategy to the ARDSnet low-positive end-expiratory pressure table in patients with moderate-to-severe acute respiratory distress syndrome due to community-acquired pneumonia admitted to intensive care units. We expect to recruit 500 patients from 20 Brazilian and 2 Colombian intensive care units. They will be randomized to a driving pressure-limiting strategy group or to a standard strategy using the ARDSNet low-positive end-expiratory pressure table. In the driving pressure-limiting strategy group, positive end-expiratory pressure will be titrated according to the best respiratory system compliance. Outcomes: The primary outcome is the number of ventilator-free days within 28 days. The secondary outcomes are in-hospital and intensive care unit mortality and the need for rescue therapies such as extracorporeal life support, recruitment maneuvers and inhaled nitric oxide. Conclusion: STAMINA is designed to provide evidence on whether a driving pressure-limiting strategy is superior to the ARDSNet low-positive end-expiratory pressure table strategy for increasing the number of ventilator-free days within 28 days in patients with moderate-to-severe acute respiratory distress syndrome. Here, we describe the rationale, design and status of the trial. Background ventilatorinduced induced pressurelimiting limiting unclear Objective endexpiratory end expiratory lowpositive low ventilatorfree free communityacquired community Methods (STAMINA multicenter openlabel open label moderatetosevere moderate severe units 50 Outcomes inhospital hospital support oxide Conclusion Here rationale 5

https://doi.org/10.62675/2965-2774.20240210-en

Contributions of the physical therapist to primary health care based on multiprofessional residency
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Freitas, Lorena de Oliveira

; Gonçalves, Jonas Loiola

; Gomes, José Edmilson Silva

; Vinhote, Juliana Freire Chagas

; Silva, Raimunda Magalhães da

; Vieira, Luiza Jane Eyre de Souza

Fisioterapia em Movimento

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2024, Volume 37 elocation e37119

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Introdução A partir da Residência Multiprofissional em Saúde (RMS) ocorre uma capacitação profissional mais direcionada para o Sistema Único de Saúde, visando a reorientação das lógicas tecnoassistenciais e contribuindo de forma significativa para a inserção e consolidação da fisioterapia na Atenção Primária à Saúde (APS). Objetivo Compreender a percepção dos profissionais e gestores de saúde sobre as contribuições da RMS para a inserção da fisioterapia na APS. Métodos Trata-se de um estudo qualitativo fundamentado na hermenêutica, desenvolvido no município de Aracati, Ceará, Brasil, com 15 profissionais por conveniência. A elegibilidade dos participantes centrou-se em profissionais de nível superior da APS em área urbana. A coleta de dados aconteceu de março a junho de 2023, através de uma entrevista semiestruturada elaborada pelos pesquisadores. A análise de dados ocorreu com base na leitura do material, organização em temáticas e interpretação por profundidade. Resultados O primeiro contato com a fisioterapia acontece em cenários que envolvem desde a consulta individual e compartilhada a programas de saúde na escola, cujas ações são otimizadas pela APS a partir da residência. As estratégias de cuidado da fisioterapia são inúmeras, principalmente ações centradas nos aspectos biopsicossociais. A inserção da fisioterapia na promoção da saúde é revelada pela inclusão do profissional em grupos de promoção da saúde. A educação em saúde na perspectiva multiprofissional é potencializadora do cuidado pelas ações de promoção e prevenção. Conclusão A residência multiprofissional fortalece a inserção da fisioterapia na APS e potencializa os cuidados primários. (RMS . (APS) Tratase Trata se hermenêutica Aracati Ceará Brasil 1 conveniência centrouse centrou urbana 2023 pesquisadores material profundidade escola inúmeras biopsicossociais prevenção primários (APS 202 20 2

Abstract Introduction Multiprofessional residency in health (MHS) is a professional training program focussed on Brazil’s Unified Health System that aims to reorient techno-assistance logics and significantly contributes to the insertion and consolidation of physical therapy into primary health care (PHC). Objective To understand the perceptions of health professionals and managers about the contributions of the MRH to the insertion of physical therapy into PHC. Methods This qualitative study was based on hermeneutics and was conducted in the municipality of Aracati, Ceará, Brazil, with 15 professionals making up a convenience sample. Eligible were PHC professionals with higher education working in urban areas. The data were collected from March to June 2023 through semistructured interviews with the researchers. The data analysis was based on reading the material, organizing it into themes, and interpreting these in depth. Results The first contact with physical therapy occurs in scenarios that range from individual and shared consultations to health programs at school, whose actions are optimized by PHC from the MHS. There are numerous physical therapy care strategies, especially actions focussed on biopsychosocial aspects. The involvement of physical therapists in health promotion is revealed by the inclusion of professionals in health promotion groups. Health education from a multiprofessional perspective enhances care through promotion and prevention. Conclusion The MHS strengthens the need for physical therapy in PHC and enhances primary care. (MHS Brazils Brazil s technoassistance techno assistance . (PHC) Aracati Ceará 1 sample areas 202 researchers material themes depth school strategies aspects groups prevention (PHC 20 2

https://doi.org/10.1590/fm.2024.37119

Occurrence of arbovirus infections in two riverine populations in the municipality of Humaitá, Amazonas, Brazil Humaitá Amazonas
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Silva, Jaqueline Carvalho de Oliveira

; Siqueira, Igor Rodrigo Ferreira

; Dornelas, Leormando Fortunato

; Ribeiro, Cristhian Magalhães

; Gomes, João Pedro Berno

; Guadagnin, Iagor Wingenbah

; Pereira, Antonieta Relvas

; Julião, Genimar Rebouças

; Camargo, Juliana de Souza Almeida Aranha

; Basano, Sergio Almeida

; Camargo, Luís Marcelo Aranha

Revista da Sociedade Brasileira de Medicina Tropical

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2024, Volume 57 elocation e00403-2024

Abstract: En | Text: En | PDF: En

ABSTRACT Background: The riverine communities of the Amazon comprise different social groups that inhabit the rural areas on the banks of rivers and lakes. Residents usually travel by river to rural and urban areas and are then exposed to urbanized diseases such as those caused by arbovirus infection. In Brazil, emerging diseases such as dengue, Zika, chikungunya, and those caused by infection with Oropouche and Mayaro viruses necessitate epidemiological surveillance. This study was aimed at determining the frequency of positivity for immunoglobulin (Ig)G and IgM antibodies against Zika, chikungunya, and dengue viruses and performing molecular analyses to detect viral RNA for the Zika, chikungunya, dengue virus, Oropouche, and Mayaro viruses, in the same serum samples obtained from riverside populations. Methods: This cross-sectional study was conducted in a riverside population in the Humaitá municipality of the Brazilian Amazon. More than 80% of the local population participated in this study. Entomological samples were collected to identify local mosquito vectors. Results: Analysis of 205 human serological samples revealed IgG antibodies against the dengue virus in 85 individuals. No molecular positivity was observed in human samples. Entomological analyses revealed 3,187 Diptera species, with Mansonia being the most frequent genus. Aedes aegypti and Aedes albopictus were not detected in the two collections. Conclusions: IgG antibodies against the dengue virus were highly prevalent, suggesting previous exposure. The absence of the arbovirus vectors Aedes aegypti and Aedes albopictus in the samples supports the hypothesis that the infections recorded likely occurred outside the riverside communities investigated. Background lakes Brazil Zika chikungunya surveillance Ig G populations Methods crosssectional cross sectional 80 Results 20 8 individuals 3187 3 187 3,18 species genus collections Conclusions prevalent exposure investigated 2 318 18 3,1 31 1 3,

https://doi.org/10.1590/0037-8682-0515-2023

10.

Substrates and containers influence the growth of Campomanesia phaea (O. Berg. Landrum) seedlings, an endangered Atlantic Rainforest species O. O (O Berg Landrum seedlings
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Santoro, Marcelo Brossi

; Gomes, Juliana Aparecida Souza

; Brogio, Bruna do Amaral

; Jacomino, Angelo Pedro

; Silva, Simone Rodrigues da

Acta Scientiarum. Agronomy

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2024, Volume 46 elocation e63904

Abstract: En | Text: En | PDF: En

ABSTRACT. Native to the Brazilian Atlantic Rainforest, cambuci fruits can be consumed either in natura or in the processed form, and cambuci trees can be used to recover degraded areas. However, studies regarding cambuci germination and seedling development are scarce. The main aim of this study was to understand how different substrates and containers influence the growth of cambuci seedlings. To this end, two experiments were conducted: five different substrates were tested in the first experiment, and based on the multivariate analysis of the first experiment, the effect of combination of the best-performing substrates and three commonly employed plant growth containers on seedling development was investigated. Overall, good quality cambuci seedlings were obtained when they were grown in the commercial pine bark substrate and peat and perlite mixture in a 260 cm3 container. ABSTRACT Rainforest form areas However scarce end conducted experiment bestperforming best performing investigated Overall 26 cm container 2

https://doi.org/10.4025/actasciagron.v46i1.63904

11.

Beckwith-Wiedemann syndrome mimicking the classical form of congenital adrenal hyperplasia in newborn screening BeckwithWiedemann Beckwith Wiedemann
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Martins, Jéssica Mallmann Erbes Schaefer

; Braga, Barbara Leitao

; Sampaio, Klevia Nunes Feitosa

; de Souza Garcia, Tamires

; Van de Sande Lee, Juliana

; Cechinel, Edson

; Simoni, Genoir

; Nascimento, Marilza Leal

; da Silva, Paulo Cesar Alves

; Fragoso, Maria C. V.

; Bachega, Tania A. A. S.

; Nishi, Mirian Y.

; Mendonca, Berenice B.

Archives of Endocrinology and Metabolism

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2024, Volume 68 elocation e220395

Abstract: En | Text: En | PDF: En

SUMMARY Beckwith-Wiedemann syndrome (BWS) is a common genetic congenital disease characterized by somatic overgrowth and its broad clinical spectrum includes pre- and post-natal macrosomia, macroglossia, visceromegaly, increased risk of neonatal hypoglycemia, and development of embryonic tumors. BWS occurs due to genetic/epigenetic changes involving growth-regulating genes, located on region 11p15, with an important genotype-phenotype correlation. Congenital adrenal hyperplasia (CAH) comprises a spectrum of autosomal recessive diseases presenting a variety of clinical manifestations due to a deficiency in one of the enzymes involved in cortisol secretion. Early diagnosis based on newborn screening prevents the adrenal crisis and early infant death. However, high 17-hydroxyprogesterone (17-OHP) levels can occur in newborns or premature infants without CAH, in situations of stress due to maternal or neonatal factors. Here, we report new cases of false-positive diagnosis of 21-hydroxylase deficiency during newborn screening – two girls and one boy with BWS. Methylation-specific multiplex ligation-dependent probe amplification revealed a gain of methylation in the H19 differentially methylated region. Notably, all three cases showed a complete normalization of biochemical changes, highlighting the transient nature of these hormonal findings that imitate the classical form of CAH. This report sheds light on a new cause of false-positive 21-hydroxylase deficiency diagnosis during newborn screening: Beckwith-Wiedemann syndrome. BeckwithWiedemann Beckwith Wiedemann (BWS pre postnatal post natal macrosomia macroglossia visceromegaly hypoglycemia tumors geneticepigenetic epigenetic growthregulating growth regulating genes 11p15 p genotypephenotype genotype phenotype correlation CAH (CAH secretion death However 17hydroxyprogesterone hydroxyprogesterone 17 17OHP OHP (17-OHP factors Here falsepositive false positive 21hydroxylase hydroxylase 21 Methylationspecific Methylation specific ligationdependent ligation dependent H H1 Notably 11p1 1 2 11p

https://doi.org/10.20945/2359-4292-2022-0395

12.

Outcomes and factors associated with tolerance in infants with non-IgE-mediated cow's milk allergy with gastrointestinal manifestations nonIgEmediated non IgE mediated cows cow s
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Vasconcelos, Príscila da Silva Pereira

; Andrade, Ana Laura Mendes Becker

; Sandy, Natascha Silva

; Barreto, Juliana Corrêa Campos

; Gomez, Gabriela Souza

; Riccetto, Adriana Gut Lopes

; Lomazi, Elizete Aparecida

; Bellomo-Brandão, Maria Ângela

Jornal de Pediatria

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2024, Volume 100 N. 1 Pages 40 - 45

Abstract: En | Text: En | PDF: En

Abstract Objectives To evaluate outcomes of oral food challenge (OFC) test to assess tolerance in infants with non-IgE-mediated cow's milk allergy (CMA) with gastrointestinal manifestations and explore clinical data predictive of these outcomes. Methods Single-center retrospective study including infants (age < 12 months) who were referred for CMA between 2000 and 2018 and underwent OFC on follow-up. A univariate logistic regression test was performed to evaluate variables associated with the outcomes of the follow-up OFC test. Results Eighty-two patients were included, 50% were male. Eighteen patients had a positive OFC test (22%). Most patients had presented with hematochezia (77%). The median age of symptom onset was 30 days. Two-thirds of the patients were on appropriate infant formula (extensively hydrolyzed or amino acid-based formula), exclusively or in association with breastfeeding. The median time on an elimination diet before the OFC test was 8 months (Q1 6 - Q3 11 months). All cases with positive follow-up OFC tests (n= 18) had been exposed to cow's milk-based formula before the first clinical manifestation of CMA. Five out of eight cases with Food Protein-Induced Enterocolitis Syndrome (FPIES) had positive OFC tests. Exposure to cow's milk-based formula before diagnosis, a history of other food allergies, hematochezia and diarrhea were predictors of a positive OFC test. Conclusions In infants with non-IgE-mediated CMPA with gastrointestinal manifestations, the use of cow's milk-based formula, a history of other food allergies, and hematochezia and diarrhea upon initial presentation were associated factors for the later achievement of tolerance. (OFC nonIgEmediated non IgE mediated cows cow s (CMA Singlecenter Single center 1 200 201 followup. followup follow up. up Eightytwo Eighty two included 50 male 22%. 22 22% . (22%) 77%. 77 77% (77%) 3 days Twothirds Two thirds extensively acidbased acid based , formula) breastfeeding Q1 Q (Q months. n= n (n 18 milkbased ProteinInduced Protein Induced FPIES (FPIES diagnosis allergies 20 5 2 (22% 7 (77% (22 (77 (2 (7 (

https://doi.org/10.1016/j.jped.2023.08.003

13.

Evaluation of different body temperature measurement methods for patients in the intraoperative period
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Nascimento, Ariane Souza do

; Lemos, Cassiane de Santana

; Biachi, Fernanda Baratojo

; Lyra, Fernanda Ribeiro Silva de

; Gnatta, Juliana Rizzo

; Poveda, Vanessa de Brito

Revista Latino-Americana de Enfermagem

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2024, Volume 32 elocation e4143

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Objetivos: este estudo teve como objetivo estimar e comparar a confiabilidade das medições de temperatura obtidas com um termômetro temporal infravermelho periférico, um termômetro cutâneo central (“ Zero-Heat-Flux ”) e um termômetro esofágico ou nasofaríngeo entre pacientes cirúrgicos eletivos no período intraoperatório. Método: estudo longitudinal com medidas repetidas realizado por amostragem de conveniência de 99 pacientes, com 18 anos ou mais, submetidos a cirurgia eletiva de câncer abdominal, com duração de anestesia de pelo menos uma hora, com cada paciente tendo sua temperatura medida pelos três métodos. Resultados: o coeficiente de correlação intraclasse mostrou uma baixa correlação entre as medições usando o termômetro temporal periférico e os termômetros cutâneo central (0,0324) e esofágico/nasofaríngeo (-0,138). Houve uma alta correlação (0,744) entre os termômetros centrais avaliados. Conclusão: os dados do presente estudo não recomendam o uso de um termômetro infravermelho temporal como estratégia para medir a temperatura corporal de pacientes submetidos a procedimentos anestésico-cirúrgicos. O termômetro cutâneo central e o termômetro esofágico/nasofaríngeo são equivalentes para detectar hipotermia intraoperatória. Objetivos ( ZeroHeatFlux Zero Heat Flux ” intraoperatório Método 9 1 mais abdominal hora métodos Resultados 0,0324 00324 0 0324 (0,0324 esofágiconasofaríngeo 0,138. 0138 0,138 . 138 (-0,138) 0,744 0744 744 (0,744 avaliados Conclusão anestésicocirúrgicos. anestésicocirúrgicos anestésico cirúrgicos. anestésico-cirúrgicos intraoperatória 0,032 0032 032 (0,032 013 0,13 13 (-0,138 0,74 074 74 (0,74 0,03 003 03 (0,03 01 0,1 (-0,13 0,7 07 7 (0,7 0,0 00 (0,0 0, (-0,1 (0, (-0, (0 (-0 (-

Objectives: this study aimed at estimating and comparing the reliability of temperature measurements obtained using a peripheral infrared temporal thermometer, a central cutaneous thermometer (“Zero-Heat-Flux Cutaneous thermometer”) and an esophageal or nasopharyngeal thermometer among elective surgical patients in the intraoperative period. Method: a longitudinal study with repeated measures carried out by convenience sampling of 99 patients, aged at least 18 years old, undergoing elective abdominal cancer surgeries, with anesthesia lasting at least one hour, with each patient having their temperature measured by all three methods. Results: the intraclass correlation coefficient showed a low correlation between the measurements using the peripheral temporal thermometer and the central cutaneous (0.0324) and esophageal/nasopharyngeal (-0.138) thermometers. There was a high correlation (0.744) between the central thermometers evaluated. Conclusion: the data from the current study do not recommend using infrared temporal thermometers as a strategy for measuring the body temperature of patients undergoing anesthetic-surgical procedures. Central cutaneous thermometers and esophageal/nasopharyngeal thermometers are equivalent for detecting intraoperative hypothermia. Objectives ZeroHeatFlux Zero Heat Flux thermometer” period Method 9 1 old surgeries hour methods Results 0.0324 00324 0 0324 (0.0324 esophagealnasopharyngeal 0.138 0138 138 (-0.138 0.744 0744 744 (0.744 evaluated Conclusion anestheticsurgical anesthetic procedures hypothermia 0.032 0032 032 (0.032 0.13 013 13 (-0.13 0.74 074 74 (0.74 0.03 003 03 (0.03 0.1 01 (-0.1 0.7 07 7 (0.7 0.0 00 (0.0 0. (-0. (0. (-0 (0 (- (

Objetivos: el objetivo de este estudio fue estimar y comparar la confiabilidad de mediciones de temperatura obtenidas por medio de un termómetro temporal infrarrojo periférico, un termómetro cutáneo central (“Termómetro cutáneo Zero-Heat-Flux ”) y un termómetro esofágico o nasofaríngeo en pacientes sometidos a cirugías electivas durante el período intraoperatorio. Método: estudio longitudinal con mediciones repetidas llevado a cabo con una muestra por conveniencia de 99 pacientes, de al menos 18 años de edad, sometidos a cirugías electivas por cáncer abdominal, con anestesia de al menos una hora de duración, y midiendo la temperatura de cada paciente con los tres métodos. Resultados: el coeficiente de correlación intraclase indicó una correlación baja entre las mediciones realizadas con el termómetro temporal periférico y los termómetros cutáneo (0,0324) y esofágico/nasofaríngeo (-0,138) centrales. Se registró una correlación alta (0,744) entre los termómetros centrales evaluados. Conclusión: los datos del presente estudio no recomiendan utilizar termómetros temporales infrarrojos como estrategia para medir la temperatura corporal de pacientes sometidos a procedimientos anestésico-quirúrgicos. Los termómetros cutáneos centrales y los esofágicos/nasofaríngeos son equivalentes para detectar hipotermia intraoperatoria. Objetivos Termómetro ZeroHeatFlux Zero Heat Flux ” intraoperatorio Método 9 1 edad abdominal duración métodos Resultados 0,0324 00324 0 0324 (0,0324 esofágiconasofaríngeo 0,138 0138 138 (-0,138 0,744 0744 744 (0,744 evaluados Conclusión anestésicoquirúrgicos. anestésicoquirúrgicos anestésico quirúrgicos. quirúrgicos anestésico-quirúrgicos esofágicosnasofaríngeos esofágicos nasofaríngeos intraoperatoria 0,032 0032 032 (0,032 0,13 013 13 (-0,13 0,74 074 74 (0,74 0,03 003 03 (0,03 0,1 01 (-0,1 0,7 07 7 (0,7 0,0 00 (0,0 0, (-0, (0, (-0 (0 (- (

https://doi.org/10.1590/1518-8345.6873.4143

14.

ARE THERE ADVANTAGES IN DOUBLE TRANSIT RECONSTRUCTION AFTER TOTAL GASTRECTOMY IN PATIENTS WITH GASTRIC CANCER? A SYSTEMATIC REVIEW CANCER
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COSTA, Luigi Carlo da Silva

; MACEDO, Ary Augusto de Castro

; ARAÚJO, Juliana Mattei de

; SILVA, Ewerton Lima da

; MORAES, Luís Felipe Gomes Reis de

; SANTOS, Aline dos

; SOARES, Hugo Gomes

; TERCIOTI JUNIOR, Valdir

; COELHO NETO, João de Souza

; ANDREOLLO, Nelson Adami

; LOPES, Luiz Roberto

ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)

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2024, Volume 37 elocation e1799

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO RACIONAL: O tratamento curativo do câncer gástrico envolve a ressecção do tumor, seguida de reconstrução do trânsito, sendo o Y-de-Roux a principal técnica empregada. Para permitir o trânsito alimentar para o duodeno, ausente em Y-de-Roux, tem-se utilizado a reconstrução de duplo trânsito, cujas vantagens teóricas parecem superar a técnica anterior. OBJETIVOS: Comparar a evolução clínica de pacientes com câncer gástrico submetidos à gastrectomia total com Y-de-Roux e reconstrução de duplo trânsito. MÉTODOS: Foi realizada uma revisão sistemática nas bases de dados: Web of Science, Scopus, Embase, Scielo, Biblioteca Virtual em Saúde, PubMed e Cochrane. Os dados foram coletados até 11 de junho de 2022. Foram incluídos estudos observacionais ou ensaios clínicos avaliando pacientes que utilizaram reconstruções de duplo trânsito (DT) e Y-de-Roux (RY). Não houve restrição temporal ou de idioma. Foram excluídos artigos de revisão, relatos de casos, séries de casos e aqueles com texto incompleto. O risco de viés foi calculado utilizando a ferramenta Cochrane desenvolvida para ensaios clínicos randomizados. RESULTADOS: Foram incluídos quatro estudos de boa qualidade metodológica, abrangendo 209 participantes. No grupo RY houve maior redução na ingestão alimentar. No grupo DT, a diminuição do índice de massa corporal (IMC) foi menos pronunciada em comparação aos valores pré-operatórios. CONCLUSÕES: A reconstrução de duplo trânsito apresentou melhores resultados em relação ao índice de massa corporal e ao tempo para início de dieta leve, porém não apresentou vantagens em relação aos déficits nutricionais, qualidade de vida e complicações pós-cirúrgicas. RACIONAL tumor YdeRoux Y Roux empregada duodeno YdeRoux, Roux, temse tem se anterior OBJETIVOS MÉTODOS Science Scopus Embase Scielo Saúde 1 2022 DT (DT RY. . (RY) idioma incompleto randomizados RESULTADOS metodológica 20 participantes IMC (IMC préoperatórios. préoperatórios pré operatórios. operatórios pré-operatórios CONCLUSÕES leve nutricionais póscirúrgicas. póscirúrgicas pós cirúrgicas. cirúrgicas pós-cirúrgicas 202 (RY 2

ABSTRACT BACKGROUND: Curative treatment for gastric cancer involves tumor resection, followed by transit reconstruction, with Roux-en-Y being the main technique employed. To permit food transit to the duodenum, which is absent in Roux-en-Y, double transit reconstruction has been used, whose theoretical advantages seem to surpass the previous technique. AIMS: To compare the clinical evolution of gastric cancer patients who underwent total gastrectomy with Roux-en-Y and double tract reconstruction. METHODS: A systematic review was carried out on Web of Science, Scopus, EmbasE, SciELO, Virtual Health Library, PubMed, Cochrane, and Google Scholar databases. Data were collected until June 11, 2022. Observational studies or clinical trials evaluating patients submitted to double tract (DT) and Roux-en-Y (RY) reconstructions were included. There was no temporal or language restriction. Review articles, case reports, case series, and incomplete texts were excluded. The risk of bias was calculated using the Cochrane tool designed for randomized clinical trials. RESULTS: Four studies of good methodological quality were included, encompassing 209 participants. In the RY group, there was a greater reduction in food intake. In the DT group, the decrease in body mass index was less pronounced compared to preoperative values. CONCLUSIONS: The double tract reconstruction had better outcomes concerning body mass index and the time until starting a light diet; however, it did not present any advantages in relation to nutritional deficits, quality of life, and post-surgical complications. BACKGROUND resection RouxenY Roux en Y employed duodenum RouxenY, Y, used AIMS METHODS Science Scopus EmbasE SciELO Library PubMed databases 11 2022 (DT (RY included restriction articles reports series excluded RESULTS 20 participants group intake values CONCLUSIONS diet however deficits life postsurgical post surgical complications 1 202 2

https://doi.org/10.1590/0102-672020240006e1799

15.

APENDIC-RADS: an ultrasound reporting system for the diagnosis of acute appendicitis APENDICRADS APENDIC RADS APENDIC-RADS
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Queiroz, Marcos Roberto Gomes de

; Jabour, Victor Arantes

; Souza Junior, José Leão de

; Paixão, Milena Ribeiro

; Silva, Paulo Savoia Dias da

; Kang, Davi Wen Wei

; Barboza, Gaby Cecilia Yupanqui Guerra

; Bourroul, Guilherme Muniz

; Lamare, Juliana Maria Haddad de

; Pontes, Irline Cordeiro de Macedo

; Pereira, Gabriela Cauper de Carvalho

; Roselli, Wanessa Rolando

; Silva, Marcelo Rocha Corrêa da

; Rahal Junior, Antonio

; Braga, Cesar Augusto Passos

; Francisco Neto, Miguel José

einstein (São Paulo)

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- SciELO Analytics

2024, Volume 22 elocation eAO1164

Abstract: En | Text: En | PDF: En

ABSTRACT Objective: Abdominal ultrasonography is widely used to evaluate suspected cases of appendicitis. Objective descriptions of the direct and indirect signs of appendicitis result in varied assessments of its likelihood. This study introduces the Appendix Imaging Reporting and Data System (APENDIC-RADS) to standardize the reporting of appendix ultrasound findings. Methods: This single-center retrospective study included consecutive patients of all ages who underwent abdominal ultrasonography for the investigation of acute appendicitis. The primary outcome was histopathological confirmation of acute appendicitis post-surgery. The imaging findings were classified into five categories: APENDIC-RADS 0, where the appendix cannot be visualized; APENDIC-RADS 1, indicating a normal appendix; APENDIC-RADS 2, describing an appendix that is likely normal but only partially visualized; APENDIC-RADS 3, appendicitis cannot be ruled out due to uncertain features and APENDIC-RADS 4, acute appendicitis. Results: A total of 747 patients were assessed for suspected acute appendicitis using ultrasonography. Of the diagnosed patients, 52% were male, primarily exhibiting symptoms such as nausea and/or vomiting (60%), right iliac fossa pain (54%), and sudden decompression in the right iliac fossa (24%). Stratification into APENDIC-RADS categories revealed a significant variation in the incidence of acute appendicitis, with incidence rates of 4.5% for category 0 and 0.7%, 2.2%, 11.5%, and 93.5% for categories 1 to 4, respectively (p<0.001). The APENDIC-RADS showed excellent discriminative ability, evidenced by an area under the receiver operating characteristic curve of 0.950 (95%CI=0.899-1). Conclusion: APENDIC-RADS categorization demonstrated excellent performance in standardizing the ultrasound-determined probability of acute appendicitis. Its implementation could improve physician communication and standardization of patient management. likelihood APENDICRADS APENDIC RADS (APENDIC-RADS Methods singlecenter single center postsurgery. postsurgery post surgery. surgery post-surgery visualized 2 3 4 Results 74 52 male andor or 60%, 60 60% , (60%) 54%, 54 54% (54%) 24%. 24 24% . (24%) 45 5 4.5 07 7 0.7% 22 2.2% 115 11 11.5% 935 93 93.5 p<0.001. p0001 p p<0.001 001 (p<0.001) ability 0950 950 0.95 95%CI=0.8991. 95CI08991 CI 95%CI=0.899 95 899 (95%CI=0.899-1) Conclusion ultrasounddetermined determined management 6 (60% (54% (24% 4. 0.7 2.2 11.5 9 93. p000 p<0.00 00 (p<0.001 095 0.9 8991 95%CI=0.8991 95CI0899 95%CI=0.89 89 (95%CI=0.899-1 (60 (54 (24 0. 2. 11. p00 p<0.0 (p<0.00 09 95CI089 95%CI=0.8 8 (95%CI=0.899- (6 (5 (2 p0 p<0. (p<0.0 95CI08 95%CI=0. (95%CI=0.899 ( p<0 (p<0. 95CI0 95%CI=0 (95%CI=0.89 p< (p<0 95CI 95%CI= (95%CI=0.8 (p< 95%CI (95%CI=0. (p (95%CI=0 (95%CI= (95%CI

https://doi.org/10.31744/einstein_journal/2024ao1164

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