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Resumo A pandemia de CoVID-19 agravou muitas problemáticas não suficientemente enfrentadas pelas políticas públicas sociais do Brasil. A evasão escolar é uma delas e afeta desproporcionalmente jovens das classes populares, em especial aqueles que são pobres, negros e periféricos, demandando corresponsabilidade de diferentes setores e atores sociais. A experiência da pesquisa/intervenção da qual decorre este texto voltou-se para as matrizes explicativas que incidiram e permanecem incidindo na ocorrência da evasão e/ou desistência escolar, além da compreensão e busca da superação dos motivos impeditivos do retorno ou da permanência do jovem à/na escola. Uma equipe interinstitucional formada por pesquisadores vinculados à Rede Metuia – Terapia Ocupacional Social, composta também por jovens universitários e jovens estudantes do Ensino Médio, vem desenvolvendo esta pesquisa/intervenção nas cidades de São Carlos e Santos (SP), João Pessoa (PB), Petrolina (PE), Brasília/Ceilândia (DF) e Simão Dias (SE). Para tanto, tendo como base a pesquisa-participante e a terapia ocupacional social, jovens universitários e jovens pesquisadores em suas escolas e/ou comunidades têm acompanhado, de forma singular e territorial, outros jovens que estão fora da escola. Agregando-se outras estratégias metodológicas, tais como questionários, photovoice, entrevistas, painel de especialistas, seminários locais e internacionais, bem como ampliando-se a ideia da “busca ativa”, que tem sido exigida dos profissionais da educação, pretende-se um cuidado ativo e democrático, corresponsabilizando todos que compõem a rede social de suporte dos jovens em seus territórios. Trata-se aqui de compartilhar essa experiência desde sua construção aos questionamentos decorrentes dos seus dois primeiros anos. CoVID19 CoVID 19 CoVID-1 Brasil populares pobres periféricos pesquisaintervenção pesquisa intervenção voltouse voltou se eou àna escola Social Médio SP, SP , (SP) PB, PB (PB) PE, PE (PE) BrasíliaCeilândia Brasília Ceilândia DF (DF SE. SE . (SE) tanto pesquisaparticipante participante acompanhado territorial Agregandose Agregando metodológicas questionários photovoice entrevistas especialistas internacionais ampliandose ampliando ativa, ativa ativa” educação pretendese pretende democrático territórios Tratase Trata anos CoVID1 1 CoVID- (SP (PB (PE (SE

Abstract The CoVID-19 pandemic exacerbated many issues insufficiently addressed by Brazil’s social public policies. School dropout is one such issue, disproportionately affecting young people from working-class backgrounds, especially those who are the poor, Black, and peripheral populations, requiring the shared responsibility of various sectors and social actors. The research/intervention experience focused on the explanatory frameworks contributing to the occurrence and persistence of school dropout and/or withdrawal, as well as understanding and seeking to overcome the obstacles preventing young people from returning to or staying in school. An interinstitutional team, comprising researchers affiliated with the Metuia Network – Social Occupational Therapy, along with young university and high-school students, has been conducting this research/intervention in the cities of São Carlos and Santos (SP), João Pessoa (PB), Petrolina (PE), Brasília/Ceilândia (DF), and Simão Dias (SE). Based on participatory action research and social occupational therapy, young university students and young researchers in their schools and/or communities have been individually and territorially following up other young people who are out of school. By incorporating additional methodological strategies, such as questionnaires, photovoice, interviews, expert panels, domestic and international seminars, and expanding the concept of “active search,” which has been required of education professionals, the aim is to provide active and democratic care, ensuring shared responsibility among all those who form the social support network for young people in their territories. This text aims to share this experience, from its inception to the questions arising from its first two years. CoVID19 CoVID 19 CoVID-1 Brazils Brazil s policies issue workingclass working class backgrounds poor Black populations actors researchintervention intervention andor withdrawal team Therapy highschool high SP, SP , (SP) PB, PB (PB) PE, PE (PE) BrasíliaCeilândia Brasília Ceilândia DF, DF (DF) SE. SE . (SE) therapy strategies questionnaires photovoice interviews panels seminars search, search professionals care territories years CoVID1 1 CoVID- (SP (PB (PE (DF (SE

https://doi.org/10.1590/2526-8910.ctore288637481

Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios and prognosis after aneurysmal subarachnoid hemorrhage: a cohort study Neutrophiltolymphocyte Neutrophil to lymphocyte platelettolymphocyte platelet hemorrhage
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Oliveira, Adilson Jose Manuel de

; Rabelo, Nicollas Nunes

; Telles, João Paulo Mota

; Solla, Davi Jorge Fontoura

; Coelho, Antonio Carlos Samaia da Silva

; Barbosa, Guilherme Bitencourt

; Barbato, Natália Camargo

; Yoshikawa, Marcia Harumy

; Teixeira, Manoel Jacobsen

; Figueiredo, Eberval Gadelha

Arquivos de Neuro-Psiquiatria

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jun 2023, Volume 81 N. 6 Pages 515 - 523

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Antecedentes O prognóstico da hemorragia subaracnoidea (HSA) permanece ruim. Vasoespasmo pode estar associado à inflamação. Razões neutrófilo-linfócito (NLR) e plaqueta-linfócito (PLR) têm sido estudadas como marcadores de inflamação e prognóstico. Objetivo Investigar NLR e PLR na admissão como preditores de vasoespasmo angiográfico e desfecho aos 6 meses. Métodos Este estudo de coorte incluiu pacientes consecutivos com HSA aneurismática de um centro terciário. Contagem de leucócitos, neutrófilos, linfócitos e plaquetas, proporção de neutrófilos para linfócitos e de plaquetas para linfócitos foram coletados como variáveis independentes. Ocorrência de vasoespasmo, escala de Rankin modificada, escala de desfecho de Glasgow e o escore de Hunt-Hess na admissão e 6 meses após a mesma foram registradas como variáveis dependentes. Modelos de regressão logística multivariável foram usados para ajustar potenciais fatores de confusão e avaliar valor prognóstico independente de NLR e PLR. Resultados Um total de 74,1% pacientes eram do sexo feminino, com idade média de 55,6 ± 12,4 anos. Na admissão, a pontuação média de Hunt-Hess foi de 2 (IQR 1) e a mediana de mFisher foi de 3 (IQR 1). Clipagem microcirúrgica foi o tratamento escolhido para 66,2% dos pacientes. A incidência de vasoespasmo angiográfico foi de 16,5%. Aos 6 meses, a escala de desfecho de Glasgow mediana era 4 (IQR 0,75) e a escala de Rankin modificada mediana era 3 (IQR 1,5). Vinte e um pacientes (15,1%) morreram. Os níveis de NLR e PLR não diferiram entre resultados funcionais favoráveis e desfavoráveis (mRS > 2 ou GOS < 4). Nenhuma variável foi significativamente associada ao vasoespasmo angiográfico. Conclusão Razão neutrófilo-linfócito e a PLR não apresentaram valor preditivo de desfecho funcional ou risco de vasoespasmo angiográfico. Mais pesquisas são necessárias neste campo. (HSA ruim neutrófilolinfócito neutrófilo linfócito (NLR plaquetalinfócito plaqueta (PLR terciário leucócitos independentes HuntHess Hunt Hess dependentes 741 74 1 74,1 feminino 556 55 55, 124 12 12, anos IQR 1. . 662 66 66,2 165 16 5 16,5% 0,75 075 0 75 1,5. 15 1,5 1,5) 15,1% 151 (15,1% morreram mRS 4. 4) campo 7 74, 66, 16,5 0,7 07 1, 15,1 (15,1 16, 0, 15, (15, (15 (1 (

Abstract Background Subarachnoid hemorrhage (SAH) prognosis remains poor. Vasospasm mechanism might be associated with inflammation. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been studied as inflammation markers and prognostic predictors. Objective We aimed to investigate NLR and PLR in admission as predictors of angiographic vasospasm and functional outcome at 6 months. Methods This cohort study included consecutive aneurysmal SAH patients admitted to a tertiary center. Complete blood count was recorded at admission before treatment. White blood cell count, neutrophil count, lymphocyte count, platelet count, NLR, and PLR were collected as independent variables. Vasospasm occurrence-modified Rankin scale (mRS), Glasgow outcome scale (GOS), and Hunt-Hess score at admission and at 6 months were recorded as dependent variables. Multivariable logistic regression models were used to adjust for potential confounding and to assess the independent prognostic value of NLR and PLR at admission. Results A total of 74.1% of the patients were female, with mean age of 55.6 ± 12.4 years. At admission, the median Hunt-Hess score was 2 (interquartile range [IQR] 1), and the median mFisher was 3 (IQR 1). Microsurgical clipping was the treatment for 66.2% of the patients. Angiographic vasospasm incidence was 16.5%. At 6 months, the median GOS was 4 (IQR 0.75), and the median mRS was 3 (IQR 1.5). Twenty-one patients (15.1%) died. Neutrophil-to-lymphocyte ratio and PLR levels did not differ between favorable and unfavorable (mRS > 2 or GOS < 4) functional outcomes. No variables were significantly associated with angiographic vasospasm. Conclusion Admission NLR and PLR presented no value for prediction of functional outcome or angiographic vasospasm risk. Further research is needed in this field. (SAH poor Neutrophiltolymphocyte Neutrophil (NLR platelettolymphocyte (PLR center occurrencemodified occurrence modified mRS, , (mRS) GOS, (GOS) HuntHess Hunt Hess 741 74 1 74.1 female 556 55 55. 124 12 12. years interquartile IQR [IQR 1, 1) 1. . 662 66 66.2 165 16 5 16.5% 0.75, 075 0.75 0 75 0.75) 1.5. 15 1.5 1.5) Twentyone Twenty one 15.1% 151 (15.1% died outcomes risk field (GOS 7 74. 66. 16.5 07 0.7 15.1 (15.1 16. 0. 15. (15. (15 (1 (

https://doi.org/10.1055/s-0043-1768662

The SISBIOTA-Diptera Brazilian Network: A long-term survey of Diptera from unexplored Brazilian Western Arc of Amazon, Cerrado, and Pantanal SISBIOTADiptera SISBIOTA Network longterm long term Amazon Cerrado
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Lamas, Carlos José Einicker

; Fachin, Diego Aguilar

; Falaschi, Rafaela Lopes

; Alcantara, Daniel Máximo Correa de

; Ale-Rocha, Rosaly

; Amorim, Dalton de Souza

; Araújo, Maíra Xavier

; Ascendino, Sharlene

; Baldassio, Letícia

; Bellodi, Carolina Ferraz

; Bravo, Freddy

; Calhau, Julia

; Capellari, Renato Soares

; Carmo-Neto, Antonio Marcelino do

; Cegolin, Bianca Melo

; Couri, Márcia Souto

; Carvalho, Claudio José Barros de

; Dios, Rodrigo de Vilhena Perez

; Falcon, Aida Vanessa Gomez

; Fusari, Livia Maria

; Garcia, Carolina de Almeida

; Gil-Azevedo, Leonardo Henrique

; Gomes, Marina Morim

; Graciolli, Gustavo

; Gudin, Filipe Macedo

; Henriques, Augusto Loureiro

; Krolow, Tiago Kütter

; Mendes, Luanna Layla

; Limeira-de-Oliveira, Francisco

; Maia, Valéria Cid

; Marinoni, Luciane

; Mello, Ramon Luciano

; Mello-Patiu, Cátia Antunes de

; Morales, Mírian Nunes

; Oliveira, Sarah Siqueira

; Patiu, Claudemir

; Proença, Barbara

; Pujol-Luz, Cristiane Vieira de Assis

; Pujol-Luz, José Roberto

; Rafael, José Albertino

; Riccardi, Paula Raile

; Rodrigues, João Paulo Vinicios

; Roque, Fabio de Oliveira

; Sallum, Maria Anice Mureb

; Santis, Marcelo Domingos de

; Santos, Charles Morphy Dias dos

; Santos, Josenilson Rodrigues dos

; Savaris, Marcoandre

; Shimabukuro, Paloma Helena Fernandes

; Silva, Vera Cristina

; Schelesky-Prado, Daniel de Castro

; Silva-Neto, Alberto Moreira da

; Camargo, Alexssandro

; Sousa, Viviane Rodrigues de

; Urso-Guimarães, Maria Virginia

; Wiedenbrug, Sofia

; Yamaguchi, Carolina

; Nihei, Silvio Shigueo

Revista Brasileira de Entomologia

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2023, Volume 67 N. 4 elocation e20230051

Abstract: En | Text: En | PDF: En

ABSTRACT The SISBIOTA-BRASIL was a three-year multimillion-dollar research program of the Brazilian government to document plants and animals in endangered/understudied areas and biomes in Brazil. Distributional patterns and the historical events that generated them are extensively unknown regarding Brazilian fauna and flora. This deficiency hinders the development of conservation policies and the understanding of evolutionary processes. Conservation decisions depend on precise knowledge of the taxonomy and geographic distribution of species. Given such a premise, we proposed to research the diversity of Diptera of the Brazilian western arc of Amazon, Cerrado, and Pantanal in the states of Mato Grosso, Mato Grosso do Sul, and Rondônia. Three important biomes of the South American continent characterize these Brazilian states: Amazon forest, Cerrado (Brazilian Savannah), and Pantanal. Besides their ecological relevance, these biomes historically lack intensive entomological surveys. Therefore, they are much underrepresented in the Brazilian natural history collections and in the scientific literature, which is further aggravated by the fact that these areas are being exponentially and rapidly converted to commercial lands. Our project involved over 90 collaborators from 24 different Brazilian institutions and one from Colombia among researchers, postdocs, graduate and undergraduate students, and technicians. We processed and analyzed nearly 300,000 specimens from ~60 families of Diptera collected with a large variety of methods in the sampled areas. Here, we provide a detailed overview of the genera and species diversity of 41 families treated. Our results point to a total of 2,130 species and 514 genera compiled and identified for the three states altogether, with an increase of 41% and 29% in the numbers of species and genera known for the three states combined, respectively. Overall, the 10 most species-rich families were Tachinidae, Cecidomyiidae, Tabanidae, Psychodidae, Sarcophagidae, Stratiomyidae, Bombyliidae, Syrphidae, Tephritidae, and Asilidae. The 10 most diverse in the number of genera were Tachinidae, Stratiomyidae, Asilidae, Mycetophilidae, Syrphidae, Tabanidae, Muscidae, Dolichopodidae, Sarcophagidae, and Chloropidae. So far, 111 scientific papers were published regarding taxonomic, phylogenetic, and biogeographical aspects of the studied families, with the description of 101 new species and three new genera. We expect that additional publications will result from this investigation because several specimens are now curated and being researched by specialists. SISBIOTABRASIL SISBIOTA BRASIL threeyear year multimilliondollar multimillion dollar endangeredunderstudied endangered understudied Brazil flora processes premise Sul Rondônia forest Savannah, Savannah , Savannah) relevance surveys Therefore literature lands 9 2 researchers postdocs students technicians 300000 300 000 300,00 60 ~6 Here 4 treated 2130 130 2,13 51 altogether 29 combined respectively Overall 1 speciesrich rich Tachinidae Cecidomyiidae Tabanidae Psychodidae Sarcophagidae Stratiomyidae Bombyliidae Syrphidae Tephritidae Asilidae Mycetophilidae Muscidae Dolichopodidae Chloropidae far 11 taxonomic phylogenetic specialists 30000 30 00 300,0 6 ~ 213 13 2,1 5 3000 3 0 300, 21 2,

https://doi.org/10.1590/1806-9665-rbent-2023-0051

Role of temporary arterial occlusion in subarachnoid hemorrhage outcomes: a prospective cohort study outcomes
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Yoshikawa, Marcia Harumy

; Rabelo, Nícollas Nunes

; Telles, João Paulo Mota

; Pipek, Leonardo Zumerkorn

; Barbosa, Guilherme Bitencourt

; Barbato, Natália Camargo

; Coelho, Antônio Carlos Samaia da Silva

; Teixeira, Manoel Jacobsen

; Figueiredo, Eberval Gadelha

Acta Cirúrgica Brasileira

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2023, Volume 38 elocation e387923

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose: Temporary arterial occlusion (TAO) is a widespread practice in the surgical treatment of intracranial aneurysms. This study aimed to investigate TAO’s role during ruptured aneurysm clipping as an independent prognostic factor on short- and long-term outcomes. Methods: This prospective cohort included 180 patients with ruptured intracranial aneurysms and an indication of microsurgical treatment. Patients who died in the first 12 hours after admission were excluded. Results: TAO was associated with intraoperative rupture (IOR) (odds ratio – OR = 10.54; 95% confidence interval – 95%CI 4.72–23.55; p < 0.001) and surgical complications (OR = 2.14; 95%CI 1.11–4.07; p = 0.01). The group with TAO and IOR had no significant difference in clinical (p = 0.06) and surgical (p = 0.94) complications compared to the group that had TAO, but no IOR. Among the 111 patients followed six months after treatment, IOR, number of occlusions, and total time of occlusion were not associated with Glasgow Outcome Scale (GOS) in the follow-up (respectively, p = 0.18, p = 0.30, and p = 0.73). Among patients who underwent TAO, IOR was also not associated with GOS in the follow-up (p = 0.29). Conclusions: TAO was associated with IOR and surgical complications, being the latter independent of IOR occurrence. In long-term analysis, neither TAO nor IOR were associated with poor clinical outcomes. Purpose (TAO TAOs s short longterm long term outcomes Methods 18 1 excluded Results (IOR odds 10.54 1054 10 54 95 95CI CI 4.72–23.55 4722355 4 72 23 55 0.001 0001 0 001 2.14 214 2 14 1.11–4.07 111407 11 07 0.01. 0.01 . 01 0.01) 0.06 006 06 0.94 094 94 occlusions (GOS followup follow up respectively, respectively (respectively 018 0.18 030 30 0.30 0.73. 073 0.73 73 0.73) 0.29. 029 0.29 29 0.29) Conclusions occurrence analysis 10.5 105 5 9 4.72–23.5 472235 7 0.00 000 00 2.1 21 1.11–4.0 11140 0.0 0.9 09 0.1 03 3 0.3 0.7 02 0.2 10. 4.72–23. 47223 2. 1.11–4. 1114 0. 4.72–23 4722 1.11–4 4.72–2 472 1.11– 4.72– 47 1.11 4.72 1.1 4.7 1. 4.

https://doi.org/10.1590/acb387923

What else in times of COVID-19? The role of minimally invasive autopsy for the differential diagnosis of acute respiratory failure in a case of kala-azar COVID19 COVID 19 COVID-19 kalaazar kala azar COVID1 1 COVID-1 COVID-
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Geber Júnior, João Carlos

; Monteiro, Renata Aparecida de Almeida

; Rocha, João Wilson Pedro da

; Duarte, Edson Luiz Társia

; Nicodemo, Elizabete

; Munhoz, Olavo

; Paiva, Edison Ferreira de

; Mauad, Thais

; Silva, Luiz Fernando Ferraz da

; Saldiva, Paulo Hilario Nascimento

; Dolhnikoff, Marisa

; Duarte-Neto, Amaro Nunes

Revista do Instituto de Medicina Tropical de São Paulo

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2023, Volume 65 elocation e36

Abstract: En | Text: En | PDF: En

ABSTRACT Visceral leishmaniasis (VL) is a chronic vector-borne zoonotic disease caused by trypanosomatids, considered endemic in 98 countries, mainly associated with poverty. About 50,000–90,000 cases of VL occur annually worldwide, and Brazil has the second largest number of cases in the world. The clinical picture of VL is fever, hepatosplenomegaly, and pancytopenia, progressing to death in 90% of cases due to secondary infections and multi-organ failure, if left untreated. We describe the case of a 25-year-old female who lived in the metropolitan area of Sao Paulo, who had recently taken touristic trips to several rural areas in Southeastern Brazil and was diagnosed post-mortem. During the hospitalization in a hospital reference for the treatment of COVID-19, the patient developed acute respiratory failure, with chest radiographic changes, and died due to refractory shock. The ultrasound-guided minimally invasive autopsy diagnosed VL (macrophages containing amastigote forms of Leishmania in the spleen, liver and bone marrow), as well as pneumonia and bloodstream infection by gram-negative bacilli. (VL vectorborne vector borne trypanosomatids 9 countries poverty 5000090000 50 000 90 50,000–90,00 worldwide world fever hepatosplenomegaly pancytopenia multiorgan multi organ failure untreated 25yearold yearold 25 year old Paulo postmortem. postmortem post mortem. mortem post-mortem COVID19, COVID19 COVID 19, 19 COVID-19 changes shock ultrasoundguided ultrasound guided macrophages spleen marrow, marrow , marrow) gramnegative gram negative bacilli 500009000 5 00 50,000–90,0 2 COVID1 1 COVID-1 50000900 0 50,000–90, COVID- 5000090 50,000–90 500009 50,000–9 50000 50,000– 5000 50,000 500 50,00 50,0 50,

https://doi.org/10.1590/s1678-9946202365036

Gestational and congenital syphilis: gaps to be elucidated syphilis
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Carvalho, Déborah Esteves

; Pimentel, João Victor Andrade

; Silva, Luise Oliveira Ribeiro da

; Rodrigues, Letícia Maria Cardoso Lima

; Andrade, Leonardo Santana

; Santana, Carlos Ramon Costa

; Menezes, Marcelo Antônio Silva

; Silva, Eloyse Emanuelle Nunes

; Santos, Gabryelle Eduarda Gama dos

; Santos, Sayron Natanael Lopes Pereira

; Gomes, Breno Gustavo do Nascimento

; Meira, Letícia Almeida

; Santos, Helga Machado de Farias

; Lopes, Izailza Matos Dantas

Revista da Sociedade Brasileira de Medicina Tropical

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2023, Volume 56 elocation e0038-2023

Abstract: En | Text: En | PDF: En

ABSTRACT Congenital and gestational syphilis are increasingly prevalent multisystemic infections in Brazil. This study aimed to present a case series of three children diagnosed with congenital syphilis even though their mother had unreactive treponemal tests. The VDRL (Venereal Disease Research Laboratory) titers of a 22-year-old mother with three pregnancies decreased after treatment. The mother did not have a reactive treponemal test, but all the three children were diagnosed with early congenital syphilis. This case series highlights the difficulty in diagnosing gestational and congenital syphilis in Brazil. Brazil tests Venereal Laboratory 22yearold yearold 22 year old treatment test 2

https://doi.org/10.1590/0037-8682-0038-2023

COVID-19-associated coagulopathy and acute kidney injury in critically ill patients COVID19associated COVIDassociated COVID 19 associated 1
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Silva, Bruno Caldin da

; Cordioli, Ricardo Luiz

; Santos, Bento Fortunato Cardoso dos

; Guerra, João Carlos de Campos

; Rodrigues, Roseny dos Reis

; Souza, Guilherme Martins de

; Ashihara, Carolina

; Midega, Thais Dias

; Campos, Niklas Söderberg

; Carneiro, Bárbara Vieira

; Campos, Flávia Nunes Dias

; Guimarães, Hélio Penna

; Matos, Gustavo Faissol Janot de

; Aranda, Valdir Fernandes de

; Ferraz, Leonardo José Rolim

; Corrêa, Thiago Domingos

einstein (São Paulo)

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2023, Volume 21 elocation eAO0119

Abstract: En | Text: En | PDF: En

ABSTRACT Objective The incidence of thrombotic events and acute kidney injury is high in critically ill patients with COVID-19. We aimed to evaluate and compare the coagulation profiles of patients with COVID-19 developing acute kidney injury versus those who did not, during their intensive care unit stay. Methods Conventional coagulation and platelet function tests, fibrinolysis, endogenous inhibitors of coagulation tests, and rotational thromboelastometry were conducted on days 0, 1, 3, 7, and 14 following intensive care unit admission. Results Out of 30 patients included, 13 (43.4%) met the criteria for acute kidney injury. Comparing both groups, patients with acute kidney injury were older: 73 (60-84) versus 54 (47-64) years, p=0.027, and had a lower baseline glomerular filtration rate: 70 (51-81) versus 93 (83-106) mL/min/1.73m2, p=0.004. On day 1, D-dimer and fibrinogen levels were elevated but similar between groups: 1780 (1319-5517) versus 1794 (726-2324) ng/mL, p=0.145 and 608 (550-700) versus 642 (469-722) g/dL, p=0.95, respectively. Rotational thromboelastometry data were also similar between groups. However, antithrombin activity and protein C levels were lower in patients who developed acute kidney injury: 82 (75-92) versus 98 (90-116), p=0.028 and 70 (52-82) versus 88 (78-101) µ/mL, p=0.038, respectively. Mean protein C levels were lower in the group with acute kidney injury across multiple time points during their stay in the intensive care unit. Conclusion Critically ill patients experiencing acute kidney injury exhibited lower endogenous anticoagulant levels. Further studies are needed to understand the role of natural anticoagulants in the pathophysiology of acute kidney injury within this population. COVID19. COVID19 COVID 19. 19 COVID-1 not tests fibrinolysis 0 1 3 7 admission included 43.4% 434 43 4 (43.4% groups older 6084 60 84 (60-84 5 4764 47 64 (47-64 years p0027 p 027 p=0.027 rate 5181 51 81 (51-81 9 83106 83 106 (83-106 mLmin173m2 mLminm mL min 73m2 m mL/min/1.73m2 p0004 004 p=0.004 Ddimer D dimer 178 13195517 1319 5517 (1319-5517 179 7262324 726 2324 (726-2324 ngmL ng ng/mL p0145 145 p=0.14 550700 550 700 (550-700 469722 469 722 (469-722 gdL g dL g/dL p095 95 p=0.95 respectively However 8 7592 75 92 (75-92 90116, 90116 90 116 , (90-116) p0028 028 p=0.02 5282 52 (52-82 78101 78 101 (78-101 µmL µ µ/mL p0038 038 p=0.038 population COVID1 COVID- 43.4 (43.4 6 (60-8 476 (47-6 p002 02 518 (51-8 8310 10 (83-10 mLmin mLmin173m 73m mL/min/1.73m p000 00 p=0.00 17 1319551 131 551 (1319-551 726232 72 232 (726-232 p014 p=0.1 55070 55 (550-70 46972 46 (469-72 p09 p=0.9 759 (75-9 9011 11 (90-116 p=0.0 528 (52-8 7810 (78-10 p003 03 p=0.03 43. (43. (60- (47- p00 (51- 831 (83-1 131955 (1319-55 72623 23 (726-23 p01 p=0. 5507 (550-7 4697 (469-7 p0 (75- 901 (90-11 (52- 781 (78-1 (43 (60 (47 (51 (83- 13195 (1319-5 7262 2 (726-2 p=0 (550- (469- (75 (90-1 (52 (78- (4 (6 (5 (83 (1319- (726- p= (550 (469 (7 (90- (78 ( (8 (1319 (726 (55 (46 (90 (131 (72 (9 (13 (1

https://doi.org/10.31744/einstein_journal/2023ao0119

IMPACTO-MR: um estudo brasileiro de plataforma nacional para avaliar infecções e multirresistência em unidades de terapia intensiva IMPACTOMR IMPACTO MR IMPACTO-MR
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Tomazini, Bruno M

; Nassar Jr, Antonio Paulo

; Lisboa, Thiago Costa

; Azevedo, Luciano César Pontes de

; Veiga, Viviane Cordeiro

; Catarino, Daniela Ghidetti Mangas

; Fogazzi, Debora Vacaro

; Arns, Beatriz

; Piastrelli, Filipe Teixeira

; Dietrich, Camila

; Negrelli, Karina Leal

; Jesuíno, Isabella de Andrade

; Reis, Luiz Fernando Lima

; Mattos, Renata Rodrigues de

; Pinheiro, Carla Cristina Gomes

; Luz, Mariane Nascimento

; Spadoni, Clayse Carla da Silva

; Moro, Elisângela Emilene

; Bueno, Flávia Regina

; Sampaio, Camila Santana Justo Cintra

; Silva, Débora Patrício

; Baldassare, Franca Pellison

; Silva, Ana Cecilia Alcantara

; Veiga, Thabata

; Barbante, Leticia

; Lambauer, Marianne

; Campos, Viviane Bezerra

; Santos, Elton

; Santos, Renato Hideo Nakawaga

; Laranjeiras, Ligia Nasi

; Valeis, Nanci

; Santucci, Eliana

; Miranda, Tamiris Abait

; Patrocínio, Ana Cristina Lagoeiro do

; Carvalho, Andréa de

; Sousa, Eduvirgens Maria Couto de

; Sousa, Ancelmo Honorato Ferraz de

; Malheiro, Daniel Tavares

; Bezerra, Isabella Lott

; Rodrigues, Mirian Batista

; Malicia, Julliana Chicuta

; Silva, Sabrina Souza da

; Gimenes, Bruna dos Passos

; Sesin, Guilhermo Prates

; Zavascki, Alexandre Prehn

; Sganzerla, Daniel

; Medeiros, Gregory Saraiva

; Santos, Rosa da Rosa Minho dos

; Silva, Fernanda Kelly Romeiro

; Cheno, Maysa Yukari

; Abrahão, Carolinne Ferreira

; Oliveira Junior, Haliton Alves de

; Rocha, Leonardo Lima

; Nunes Neto, Pedro Aniceto

; Pereira, Valéria Chagas

; Paciência, Luis Eduardo Miranda

; Bueno, Elaine Silva

; Caser, Eliana Bernadete

; Ribeiro, Larissa Zuqui

; Fernandes, Caio Cesar Ferreira

; Garcia, Juliana Mazzei

; Silva, Vanildes de Fátima Fernandes

; Santos, Alisson Junior dos

; Machado, Flávia Ribeiro

; Souza, Maria Aparecida de

; Ferronato, Bianca Ramos

; Urbano, Hugo Corrêa de Andrade

; Moreira, Danielle Conceição Aparecida

; Souza-Dantas, Vicente Cés de

; Duarte, Diego Meireles

; Coelho, Juliana

; Figueiredo, Rodrigo Cruvinel

; Foreque, Fernanda

; Romano, Thiago Gomes

; Cubos, Daniel

; Spirale, Vladimir Miguel

; Nogueira, Roberta Schiavon

; Maia, Israel Silva

; Zandonai, Cassio Luis

; Lovato, Wilson José

; Cerantola, Rodrigo Barbosa

; Toledo, Tatiana Gozzi Pancev

; Tomba, Pablo Oscar

; Almeida, Joyce Ramos de

; Sanches, Luciana Coelho

; Pierini, Leticia

; Cunha, Mariana

; Sousa, Michelle Tereza

; Azevedo, Bruna

; Dal-Pizzol, Felipe

; Damasio, Danusa de Castro

; Bainy, Marina Peres

; Beduhn, Dagoberta Alves Vieira

; Jatobá, Joana D’Arc Vila Nova

; Moura, Maria Tereza Farias de

; Rego, Leila Rezegue de Moraes

; Silva, Adria Vanessa da

; Oliveira, Luana Pontes

; Sodré Filho, Eliene Sá

; Santos, Silvana Soares dos

; Neves, Itallo de Lima

; Leão, Vanessa Cristina de Aquino

; Paes, João Lucidio Lobato

; Silva, Marielle Cristina Mendes

; Oliveira, Cláudio Dornas de

; Santiago, Raquel Caldeira Brant

; Paranhos, Jorge Luiz da Rocha

; Wiermann, Iany Grinezia da Silva

; Pedroso, Durval Ferreira Fonseca

; Sawada, Priscilla Yoshiko

; Prestes, Rejane Martins

; Nascimento, Glícia Cardoso

; Grion, Cintia Magalhães Carvalho

; Carrilho, Claudia Maria Dantas de Maio

; Dantas, Roberta Lacerda Almeida de Miranda

; Silva, Eliane Pereira

; Silva, Antônio Carlos da

; Oliveira, Sheila Mara Bezerra de

; Golin, Nicole Alberti

; Tregnago, Rogerio

; Lima, Valéria Paes

; Silva, Kamilla Grasielle Nunes da

; Boschi, Emerson

; Buffon, Viviane

; Machado, André Sant’Ana

; Capeletti, Leticia

; Foernges, Rafael Botelho

; Carvalho, Andréia Schubert de

; Oliveira Junior, Lúcio Couto de

; Oliveira, Daniela Cunha de

; Silva, Everton Macêdo

; Ribeiro, Julival

; Pereira, Francielle Constantino

; Salgado, Fernanda Borges

; Deutschendorf, Caroline

; Silva, Cristofer Farias da

; Gobatto, Andre Luiz Nunes

; Oliveira, Carolaine Bomfim de

; Dracoulakis, Marianna Deway Andrade

; Alvaia, Natália Oliveira Santos

; Souza, Roberta Machado de

; Araújo, Larissa Liz Cardoso de

; Melo, Rodrigo Morel Vieira de

; Passos, Luiz Carlos Santana

; Vidal, Claudia Fernanda de Lacerda

; Rodrigues, Fernanda Lopes de Albuquerque

; Kurtz, Pedro

; Shinotsuka, Cássia Righy

; Tavares, Maria Brandão

; Santana, Igor das Virgens

; Gavinho, Luciana Macedo da Silva

; Nascimento, Alaís Brito

; Pereira, Adriano J

; Cavalcanti, Alexandre Biasi

Revista Brasileira de Terapia Intensiva

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dec 2022, Volume 34 N. 4 Pages 418 - 425

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Descrever o IMPACTO-MR, um estudo brasileiro de plataforma nacional em unidades de terapia intensiva focado no impacto das infecções por bactérias multirresistentes relacionadas à assistência à saúde. Métodos: Descrevemos a plataforma IMPACTO-MR, seu desenvolvimento, critérios para seleção das unidades de terapia intensiva, caracterização da coleta de dados, objetivos e projetos de pesquisa futuros a serem realizados na plataforma. Resultados: Os dados principais foram coletados por meio do Epimed Monitor System® e consistiram em dados demográficos, dados de comorbidades, estado funcional, escores clínicos, diagnóstico de internação e diagnósticos secundários, dados laboratoriais, clínicos e microbiológicos e suporte de órgãos durante a internação na unidade de terapia intensiva, entre outros. De outubro de 2019 a dezembro de 2020, 33.983 pacientes de 51 unidades de terapia intensiva foram incluídos no banco de dados principal. Conclusão: A plataforma IMPACTO-MR é um banco de dados clínico brasileiro de unidades de terapia intensiva focado na pesquisa do impacto das infecções por bactérias multirresistentes relacionadas à assistência à saúde. Essa plataforma fornece dados para o desenvolvimento e pesquisa de unidades de terapia intensiva individuais e ensaios clínicos observacionais e prospectivos multicêntricos. Objetivo IMPACTOMR, IMPACTOMR IMPACTO MR, MR saúde Métodos Resultados System demográficos comorbidades funcional secundários laboratoriais outros 201 2020 33983 33 983 33.98 5 principal Conclusão multicêntricos 20 202 3398 3 98 33.9 2 339 9 33.

ABSTRACT Objective: To describe the IMPACTO-MR, a Brazilian nationwide intensive care unit platform study focused on the impact of health care-associated infections due to multidrug-resistant bacteria. Methods: We described the IMPACTO-MR platform, its development, criteria for intensive care unit selection, characterization of core data collection, objectives, and future research projects to be held within the platform. Results: The core data were collected using the Epimed Monitor System® and consisted of demographic data, comorbidity data, functional status, clinical scores, admission diagnosis and secondary diagnoses, laboratory, clinical, and microbiological data, and organ support during intensive care unit stay, among others. From October 2019 to December 2020, 33,983 patients from 51 intensive care units were included in the core database. Conclusion: The IMPACTO-MR platform is a nationwide Brazilian intensive care unit clinical database focused on researching the impact of health care-associated infections due to multidrug-resistant bacteria. This platform provides data for individual intensive care unit development and research and multicenter observational and prospective trials. Objective IMPACTOMR, IMPACTOMR IMPACTO MR, MR careassociated associated multidrugresistant multidrug resistant bacteria Methods selection collection objectives Results System status scores diagnoses laboratory stay others 201 2020 33983 33 983 33,98 5 Conclusion trials 20 202 3398 3 98 33,9 2 339 9 33,

https://doi.org/10.5935/0103-507x.20220209-pt

Microsurgery versus embolization: different risk factors for short- and longterm outcomes of patients with ruptured aneurysms
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Yoshikawa, Marcia Harumy

; Rabelo, Nícollas Nunes

; Telles, João Paulo Mota

; Barbosa, Guilherme Bitencourt

; Barbato, Natália Camargo

; Coelho, Antônio Carlos Samaia da Silva

; Pipek, Leonardo Zumerkorn

; Teixeira, Manoel Jacobsen

; Figueiredo, Eberval Gadelha

Acta Cirúrgica Brasileira

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2022, Volume 37 N. 8 elocation e370806

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose: To evaluate the risk factors for poor outcomes after surgical and endovascular treatment of aneurysmal subarachnoid hemorrhage (aSAH). Methods: Patients with ≥ 18-years of age and aSAH were included, while patients who died within 12 h of admission or lost follow-up were excluded. All participants underwent standardized clinical and radiological assessment on admission and were reassessed at discharge and at 6-months follow-up using the Glasgow Outcome Scale (GOS). Results: Death at discharge was associated with female gender, anterior communication artery (ACoA) aneurysm location and presence of atherosclerotic plaque in the surgical group, and with age in the endovascular group. Both groups had clinical condition on follow-up associated with mFisher score on admission and hypertension. GOS on follow-up was also associated with presence of atherosclerotic plaque and multiple aneurysms in surgical group, and with age in endovascular group. Conclusions: Subjects treated surgically are prone to unfavorable outcomes if atherosclerotic plaques and multiple aneurysms are present. In patients with endovascular treatment, age was the main predictor of clinical outcome.

https://doi.org/10.1590/acb370806

10.

Protein and carbohydrate profiles of 'Massai' grass silage with pelleted citrus pulp and microbial inoculant
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Anjos, Amanda Nunes Assis dos

; Almeida, João Carlos de Carvalho

; Viegas, Carlos Renato

; Silva, Pedro Henrique Ferreira da

; Morais, Leonardo Fiusa de

; Nepomuceno, Delci de Deus

; Carvalho, Carlos Augusto Brandão de

; Soares, Felipe Almeida

Pesquisa Agropecuária Brasileira

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2022, Volume 57 elocation e02732

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O objetivo deste trabalho foi avaliar os efeitos das inclusões de polpa cítrica peletizada e de inoculante microbiano sobre características fermentativas, fracionamento de carboidratos e proteínas, e teores de nutrientes digestíveis totais de silagem de capim 'Massai' (Megathyrsus maximus × Megathyrsus infestus). O delineamento experimental foi inteiramente casualizado, em arranjo fatorial 2×4 (aplicação ou não de inoculante × 0, 10, 20 e 30% de polpa cítrica), com cinco repetições. Houve aumento da recuperação de matéria seca em função dos níveis de polpa cítrica. Os valores obtidos para pH e nitrogênio amoniacal indicaram adequado processo fermentativo. Sob níveis crescentes de polpa cítrica, houve redução dos teores de fibra insolúvel em detergente neutro e aumento do teor de carboidratos não fibrosos e proteína ligada à fibra. O teor de nutrientes digestíveis totais atinge ponto máximo de 513,1 g kg1 com a inclusão de 12,50% de polpa cítrica. O inoculante microbiano, quando isolado, não influencia os perfis de carboidratos e proteínas. Inclusões entre 10 e 20% de polpa cítrica são capazes de manter parâmetros fermentativos adequados e melhorar o perfil de nutrientes digestíveis, com adequada recuperação de matéria seca.

Abstract The objective of this work was to evaluate the effects of the inclusion of pelleted citrus pulp and microbial inoculant on the fermentation characteristics, carbohydrate and protein fractionation, and total digestible nutrient contents of 'Massai' grass (Megathyrsus maximus × Megathyrsus infestus) silage. The experimental design was completely randomized, in a 2×4 factorial arrangement (application or not of inoculant × 0, 10, 20, and 30% citrus pulp) with five replicates. There was an increase in dry matter recovery as affected by citrus pulp levels. The values obtained for pH and ammonia nitrogen indicated an adequate fermentation process. Under increasing citrus pulp levels, there was a reduction in neutral detergent fiber and an increase in nonfibrous carbohydrate contents and in protein linked to fiber. Total digestible nutrient content reaches a peak of 513.1 g kg1 with the inclusion of 12.50% citrus pulp. The microbial inoculant, when isolated, does not influence carbohydrate and protein profiles. Inclusions between 10 and 20% citrus pulp are able to maintain adequate fermentative parameters and improve the digestible nutrient profile, with an adequate dry matter recovery.

https://doi.org/10.1590/s1678-3921.pab2022.v57.02732

11.

Resistance of Brazilian wheat cultivars to blast under controlled condition
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Maciel, João Leodato Nunes

; Santos, Gustavo Bilíbio dos

; Pizolotto, Carlos Augusto

; Kovaleski, Marcos

; Silva, Alieze Nascimento da

; Deuner, Carolina Cardoso

; Costa, Ivan Francisco Dressler da

Ciência Rural

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2022, Volume 52 N. 7 elocation e20210417

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: O primeiro relato da brusone do trigo no mundo foi no Brasil, em 1986. Desde então, tem-se realizado um esforço muito grande com vistas ao desenvolvimento de cultivares de trigo resistentes a esta doença, a qual é causada pelo fungo Pyricularia oryzae Triticum (PoT). O objetivo deste trabalho foi de (i) avaliar a resistência de genótipos de trigo à brusone e (ii) verificar a correlação entre severidade da doença em espigas e taxa de esporulação de PoT em ráquis de espigas. Plantas de 40 cultivares brasileiras de trigo crescidas em vasos, no estádio de florescimento (estádio 65 da escala de Zadoks), foram submetidas à inoculação com uma suspensão de conídios de um isolado de PoT representativo da principal variante do fungo encontrada no Brasil. A severidade de brusone nas espigas aos cinco e sete dias após a inoculação (dai) e a taxa de esporulação do fungo nas ráquis (conídios por g de ráquis) foram avaliadas. Oitenta por cento das cultivares que foram classificadas no grupo com menor taxa de esporulação também foram classificadas no grupo de maior resistência aos sete dai. Entretanto, os coeficientes de correlação da análise estabelecida entre as médias de severidade das cultivares aos cinco e sete dai e as médias da taxa de esporulação de PoT não foram significativos (r=0,2464 e r=0,2047, respectivamente). Os resultados obtidos representam a caracterização atualizada da reação à brusone de cultivares de trigo do Brasil e constituem-se em importante marco exploratório da avaliação da reação de genótipos de trigo baseado na taxa de esporulação de PoT em seus tecidos.

ABSTRACT: The first report of wheat blast in the world was in Brazil, in 1986. Since then, a great effort has been made towards the development of wheat cultivars resistant to this disease, which is caused by the fungus Pyricularia oryzae Triticum (PoT). The objective of this research was to (i) evaluate the resistance of wheat genotypes to blast and (ii) verify the correlation between disease severity on wheat spikes and sporulation rate of PoT on spike rachises. Plants of 40 cultivars grown in pots, at the flowering stage (stage 65 on the Zadoks scale), were inoculated with a suspension of conidia of a PoT isolate representative of the main variant of the fungus reported in Brazil. Severity of blast on the spikes at 5 and 7 days after inoculation (dai) and the rate of sporulation of the fungus on the rachis (conidia per g of rachis) were evaluated. Eighty percent of the cultivars that were classified in the group with the lowest sporulation rate were also classified in the group with the highest resistance at 7 dai. However, the correlation coefficients of the analysis established between the cultivar severity at 5 and 7 dai averages and the PoT sporulation rate averages were not significant (r=0.2464 and r=0.2047, respectively). Results obtained represent the updated characterization to blast of wheat cultivars in Brazil and constitute an important exploratory framework for the evaluation of the reaction of wheat genotypes based on the sporulation rate of PoT on their tissues.

https://doi.org/10.1590/0103-8478cr20210417

12.

Scrotal hemangiosarcoma in a Large White boar
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Silveira, Renato Luiz

; Cruz, Ana Claudia de Menezes

; Doria, Phillipe Bauer de Araújo

; Silveira, Joao Marcelo Silva

; Vasconcelos, Carlos Otávio de Paula

; Rodrigues, André Luis Rios

; Arashiro, Eduardo Kenji Nunes

; Jerdy, Hassan

; Dias, Mariana Tavares

; Carvalho, Eulógio Carlos Queiroz de

; Costa, Carlos Henrique Campello

Ciência Rural

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2022, Volume 52 N. 4 elocation e20210157

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Na espécie suína os tumores são pouco diagnosticados devido a curta vida útil dos animais de produção. Normalmente não causam sinais clínicos, sendo, muitas vezes, encontrados no momento do abate. Um reprodutor com dois anos de idade, da raça Large White, utilizado no manejo reprodutivo de uma granja, sem histórico de problemas pré-existentes, foi examinado em função de lesões na pele da bolsa escrotal. Foram coletadas amostras de segmentos de pele contendo lesões para o diagnóstico histopatológico e imunohistoquímico. Microscopicamente os nodos em bolsa escrotal consistiam em neoplasias mal demarcadas, altamente celulares, expansivas e multifocalmente invasivas composta por endoteliócitos imaturos organizados em formações neovasculares. As células tumorais eram pleomórficas, levemente ovais a fusiformes com citoplasma eosinofílico e núcleos hipercromáticos e com um a três nucléolos. Todos os nódulos analisados foram compatíveis com hemangiossarcoma. Para a quantificação da angiogênese tecidual, após a avaliação imunohistoquímica, as células neoplásicas imunoexpressaram os anticorpos monoclonais CD31 e Fator VIII, através da identificação de proteínas expressas na superfície das células endoteliais. Observou-se o marcador de proliferação celular Ki67 positivo em aproximadamente 10% das células neoplásicas, demonstrando um alto grau de malignidade. O hemangiossarcoma na espécie suína já foi identificado em vários órgãos e tecidos, mas, até o momento, nenhum trabalho demonstrou o diagnóstico na pele da bolsa escrotal, como reportado, ineditamente, neste estudo. Face o exposto, espera-se que este relato contribua para a frequência de neoplasias encontradas na espécie suína.

ABSTRACT: Tumors are rarely diagnosed in swine specie because of the short lifespan of production animals. Normally, these tumors do not present any clinical signs and are often detected at the time of slaughter. A 2-year-old Large White boar, used in the reproductive management of a farm and without a history of pre-existing problems, was examined for skin lesions on the scrotum. Samples were collected from skin segments containing lesions for histopathological and immunohistochemical diagnosis. Microscopically, the nodes in the scrotum pouch consisted of poorly demarcated, highly cellular, expansile, and multifocally invasive neoplasms, composed of immature endotheliocytes organized into neovascular formations. The tumor cells were pleomorphic, slightly oval to spindle-shaped, with eosinophilic cytoplasm and hyperchromatic nuclei with one to three nucleoli. All the nodules analyzed were compatible with hemangiosarcoma. After immunohistochemical evaluation, for the quantification of tissue angiogenesis the neoplastic cells immunoexpressed the CD31 monoclonal antibodies and factor VIII, through the identification of proteins expressed on the surface of endothelial cells. The Ki67 cell proliferation marker was positive in approximately 10% of the neoplastic cells, demonstrating a high degree of malignancy. Hemangiosarcoma in swine species has already been identified in several organs and tissues; however, to date, no study has demonstrated the diagnosis of this condition on the skin of the scrotum, as reported in this study. Therefore, it is expected that this report will contribute to the knowledge of the frequency of neoplasms in swine species.

https://doi.org/10.1590/0103-8478cr2021015 69 downloads

13.

Could outcomes of intracranial aneurysms be better predict using serum creatinine and glomerular filtration rate?
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Rabelo, Nícollas Nunes

; Pipek, Leonardo Zumerkorn

; Nascimento, Rafaela Farias Vidigal

; Telles, João Paulo Mota

; Barbato, Natalia Camargo

; Coelho, Antônio Carlos Samaia da Silva

; Barbosa, Guilherme Bitencourt

; Yoshikawa, Marcia Harumy

; Teixeira, Manoel Jacobsen

; Figueiredo, Eberval Gadelha

Acta Cirúrgica Brasileira

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2022, Volume 37 N. 1 elocation e370107

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose: To analyze the role of serum creatinine levels as a biomarker of intracranial aneurysm outcomes. Methods: This is a prospective analysis of outcomes of patients with intracranial aneurysm. One hundred forty-seven patients with serum creatinine at admission and 6 months follow up were included. Linear and logistic regressions were used to analyze the data. Modified Rankin scale (mRS) was used to assess outcome. Results: Creatinine level was not directly related to aneurysm outcome nor aneurysm rupture (p > 0.05). However, patients with a glomerular filtration rate (GFR) lower than 72.50 mL·min–1 had an odds ratio (OR) of 3.049 (p = 0.006) for worse outcome. Similarly, aneurysm rupture had an OR of 2.957 (p = 0.014) for worse outcomes. Stepwise selection model selected 4 variables for outcomes prediction: serum creatinine, sex, hypertension and treatment. Hypertensive patients had, on average, an increase in 0.588 in mRS (p = 0.022), while treatment with microsurgery had a decrease in 0.555 (p = 0.038). Conclusions: Patients with higher GFR had better outcomes after 6 months. Patients with higher GFR had better outcomes after 6 months. Creatinine presented an indirect role in GFR values and should be included in models for outcome prediction.

https://doi.org/10.1590/acb370107

14.

Geotechnical properties of some kaolinite-rich Brazilian Vertisols
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Barbosa, Gustavo Magalhães Nunes

; Marques, Eduardo Antonio Gomes

; Ker, João Carlos

; Assis, Igor Rodrigues de

; Cunha, Tony Jarbas Ferreira

; Souza, Luciano da Silva

Revista Brasileira de Ciência do Solo

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2021, Volume 45 elocation e0210022

Abstract: En | Text: En | PDF: En

Abstract Vertisols presenting kaolinite codominance or prevalence were already reported in several countries worldwide. However, the literature has few studies focused on investigating the influence of this clay mineral in soil geotechnical behavior. This study aimed to carry out the characterization of Vertisols in Bahia State, Brazil, to understand the influence of physical, chemical, and mineralogical properties on their geotechnical behavior, as these soils have high natural fertility and have been used for agricultural activity, but with great risk due to their physical and geotechnical properties. Six Vertisols were selected, three located in Juazeiro County (Semiarid region) and the other three in Recôncavo region. Geotechnical characterization of selected soils was carried out in their respective diagnostic horizons by determining properties such as granulometric curve, Atterberg limits, clay activity, linear expansion coefficient, compaction capacity, cohesion (c), and internal friction angle (ϕ) of saturated soils. Soil expansion potential was associated with expansive clay contents and clay content in each soil sample. The best soil compaction efficiency was observed for kaolinitic Vertisol, which presented greater void ratio reduction and higher density due to moisture increase. In addition, c increased as kaolinite content also increased and decreased as clay content increased in soils presenting similar mineralogy. On the other hand, ϕ was influenced mainly by granulometry since higher sand and gravel levels enabled higher ϕ, regardless of clay type.

https://doi.org/10.36783/18069657rbcs20210022 76 downloads

15.

Differences in children and adolescents with SARS-CoV-2 infection: a cohort study in a Brazilian tertiary referral hospital
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Marques, Heloisa Helena de Sousa

; Pereira, Maria Fernanda Badue

; Santos, Angélica Carreira dos

; Fink, Thais Toledo

; Paula, Camila Sanson Yoshino de

; Litvinov, Nadia

; Schvartsman, Claudio

; Delgado, Artur Figueiredo

; Gibelli, Maria Augusta Bento Cicaroni

; Carvalho, Werther Brunow de

; Odone Filho, Vicente

; Tannuri, Uenis

; Carneiro-Sampaio, Magda

; Grisi, Sandra

; Duarte, Alberto José da Silva

; Antonangelo, Leila

; Francisco, Rossana Pucineli Vieira

; Okay, Thelma Suely

; Batisttella, Linamara Rizzo

; Carvalho, Carlos Roberto Ribeiro de

; Brentani, Alexandra Valéria Maria

; Silva, Clovis Artur

; Eisencraft, Adriana Pasmanik

; Rossi Junior, Alfio

; Fante, Alice Lima

; Cora, Aline Pivetta

; Reis, Amelia Gorete A. de Costa

; Ferrer, Ana Paula Scoleze

; Andrade, Anarella Penha Meirelles de

; Watanabe, Andreia

; Gonçalves, Angelina Maria Freire

; Waetge, Aurora Rosaria Pagliara

; Silva, Camila Altenfelder

; Ceneviva, Carina

; Lazari, Carolina dos Santos

; Abellan, Deipara Monteiro

; Santos, Emilly Henrique dos

; Sabino, Ester Cerdeira

; Bianchini, Fabíola Roberta Marim

; Alcantara, Flávio Ferraz de Paes

; Ramos, Gabriel Frizzo

; Leal, Gabriela Nunes

; Rodriguez, Isadora Souza

; Pinho, João Renato Rebello

; Carneiro, Jorge David Avaizoglou

; Paz, Jose Albino

; Ferreira, Juliana Carvalho

; Ferranti, Juliana Ferreira

; Ferreira, Juliana de Oliveira Achili

; Framil, Juliana Valéria de Souza

; Silva, Katia Regina da

; Kanunfre, Kelly Aparecida

; Bastos, Karina Lucio de Medeiros

; Galleti, Karine Vusberg

; Cristofani, Lilian Maria

; Suzuki, Lisa

; Campos, Lucia Maria Arruda

; Perondi, Maria Beatriz de Moliterno

; Diniz, Maria de Fatima Rodrigues

; Fonseca, Maria Fernanda Mota

; Cordon, Mariana Nutti de Almeida

; Pissolato, Mariana

; Peres, Marina Silva

; Garanito, Marlene Pereira

; Imamura, Marta

; Dorna, Mayra de Barros

; Luglio, Michele

; Rocha, Mussya Cisotto

; Aikawa, Nadia Emi

; Degaspare, Natalia Viu

; Sakita, Neusa Keico

; Udsen, Nicole Lee

; Scudeller, Paula Gobi

; Gaiolla, Paula Vieira de Vincenzi

; Severini, Rafael da Silva Giannasi

; Rodrigues, Regina Maria

; Toma, Ricardo Katsuya

; Paula, Ricardo Iunis Citrangulo de

; Palmeira, Patricia

; Forsait, Silvana

; Farhat, Sylvia Costa Lima

; Sakano, Tânia Miyuki Shimoda

; Koch, Vera Hermina Kalika

; Cobello Junior, Vilson

Clinics

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2021, Volume 76 elocation e3488

Abstract: En | Text: En | PDF: En

OBJECTIVES: To compare demographic/clinical/laboratory/treatments and outcomes among children and adolescents with laboratory-confirmed coronavirus disease 2019 (COVID-19). METHODS: This was a cross-sectional study that included patients diagnosed with pediatric COVID-19 (aged <18 years) between April 11, 2020 and April 22, 2021. During this period, 102/5,951 (1.7%) of all admissions occurred in neonates, children, and adolescents. Furthermore, 3,962 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection samples were processed in patients aged <18 years, and laboratory-confirmed COVID-19 occurred in 155 (4%) inpatients and outpatients. Six/155 pediatric patients were excluded from the study. Therefore, the final group included 149 children and adolescents (n=97 inpatients and 52 outpatients) with positive SARS-CoV-2 results. RESULTS: The frequencies of sore throat, anosmia, dysgeusia, headache, myalgia, nausea, lymphopenia, pre-existing chronic conditions, immunosuppressive conditions, and autoimmune diseases were significantly reduced in children and adolescents (p<0.05). Likewise, the frequencies of enoxaparin use (p=0.037), current immunosuppressant use (p=0.008), vasoactive agents (p=0.045), arterial hypotension (p<0.001), and shock (p=0.024) were significantly lower in children than in adolescents. Logistic regression analysis showed that adolescents with laboratory-confirmed COVID-19 had increased odds ratios (ORs) for sore throat (OR 13.054; 95% confidence interval [CI] 2.750-61.977; p=0.001), nausea (OR 8.875; 95% CI 1.660-47.446; p=0.011), and lymphopenia (OR 3.575; 95% CI 1.355-9.430; p=0.010), but also had less hospitalizations (OR 0.355; 95% CI 0.138-0.916; p=0.032). The additional logistic regression analysis on patients with preexisting chronic conditions (n=108) showed that death as an outcome was significantly associated with pediatric severe acute respiratory syndrome (SARS) (OR 22.300; 95% CI 2.341-212.421; p=0.007) and multisystem inflammatory syndrome in children (MIS-C) (OR 11.261; 95% CI 1.189-106. 581; p=0.035). CONCLUSIONS: Half of the laboratory-confirmed COVID-19 cases occurred in adolescents. Individuals belonging to this age group had an acute systemic involvement of SARS-CoV-2 infection. Pediatric SARS and MIS-C were the most important factors associated with the mortality rate in pediatric chronic conditions with COVID-19.

https://doi.org/10.6061/clinics/2021/e3488

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