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Abstract Introduction: Multicenter research initiatives in Brazilian dialysis centers are scarce. We described the recruitment and implementation phases of the SARC-HD study, aimed at investigating sarcopenia and its impact on adverse clinical outcomes. Methods: The SARC-HD is a cohort study being conducted with patients on hemodialysis in Brazil. The recruitment phase was defined as the period from the invitation to the center until the start of patient enrollment, whereas the implementation phase lasted from then until the completion of enrollment and baseline data collection. Upon implementation, a structured questionnaire was distributed to collect feedback from principal investigators. Results: 21 centers from three Brazilian regions consented to participate, with two dropping out. Ten principal investigators oversaw the 19 sites. Nine centers (47%) were funded entirely by health insurance companies. A total of 1525 patients were screened for eligibility and 1008 were enrolled, with a 66.1% recruitment rate. Recruitment and baseline data collection took 12 [interquartile range: 5–15] weeks. Qualitative content analysis identified barriers such as a lack of infrastructure and logistics for research. Facilitators included the management and organization of the steering committee. Data collection challenges were mainly reported with the subjective 7-point global assessment and the international physical activity questionnaire. The main challenge for the ongoing maintenance phase will be the lack of standardized information in electronic health records. Conclusions: The recruitment and implementation phases of the multicenter SARC-HD study were feasible. Barriers and facilitators identified by principal investigators may help future multicenter initiatives to integrate research-related tasks into clinical routine, facilitating successful experiences. Introduction scarce SARCHD SARC HD outcomes Methods Brazil Results 2 participate out 1 sites 47% 47 (47% companies 152 100 enrolled 661 66 66.1 rate interquartile range 5–15 515 5 15 weeks committee 7point point 7 records Conclusions feasible researchrelated related routine experiences 4 (47 10 6 66. 5–1 51 (4 5– (

Resumo Introdução: Pesquisa multicêntrica em centros de diálise brasileiros são escassas. Descrevemos as fases de recrutamento e implementação do estudo SARC-HD, visando investigar a sarcopenia e seu impacto em desfechos clínicos adversos. Métodos: O SARC-HD é um estudo de coorte realizado com pacientes em hemodiálise no Brasil. A fase de recrutamento foi considerada o período entre convite ao centro e início da inclusão de pacientes, enquanto a fase de implementação durou a partir de então até a conclusão do recrutamento e coleta de dados basais. Após a implementação, um questionário estruturado foi distribuído para coletar feedback dos principais pesquisadores. Resultados: 21 centros de três regiões brasileiras consentiram em participar, com duas desistências. Dez pesquisadores principais supervisionaram 19 locais. Nove centros (47%) eram totalmente financiados por planos de saúde. 1525 pacientes foram avaliados para elegibilidade e 1008 foram incluídos, com taxa de recrutamento de 66,1%. Recrutamento e coleta de dados basais levaram 12 semanas [intervalo interquartil: 5–15]. A análise qualitativa de conteúdo identificou barreiras como falta de infraestrutura e logística para pesquisa. Os facilitadores incluíram gestão e organização do comitê gestor. Os desafios da coleta de dados foram relatados principalmente quanto à avaliação global subjetiva de 7 pontos e o questionário internacional de atividade física. O principal desafio para a fase de manutenção será a falta de informações padronizadas nos prontuários eletrônicos. Conclusões: As fases de recrutamento e implementação do estudo multicêntrico SARC-HD foram viáveis. Barreiras e facilitadores identificados pelos pesquisadores principais podem auxiliar futuras iniciativas multicêntricas a integrar tarefas relacionadas à pesquisa na rotina clínica, facilitando experiências bem-sucedidas. Introdução escassas SARCHD, SARCHD SARC HD, HD adversos Métodos Brasil Resultados 2 participar desistências 1 locais 47% 47 (47% saúde 152 100 incluídos 661 66 66,1% intervalo interquartil 5–15. 515 5–15 . 5 15 5–15] gestor física eletrônicos Conclusões viáveis clínica bemsucedidas. bemsucedidas bem sucedidas. sucedidas bem-sucedidas 4 (47 10 6 66,1 51 5–1 (4 66, 5– (

https://doi.org/10.1590/2175-8239-jbn-2024-0009en

[SciELO Preprints] - Guidelines on the Diagnosis and Treatment of Hypertrophic Cardiomyopathy – 2024
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Fernandes, Fabio Simões, Marcus V. Correia, Edileide de Barros Marcondes-Braga, Fabiana G. Coelho-Filho, Otavio Rizzi Mesquita, Cláudio Tinoco Mathias-Junior, Wilson Rochitte, Carlos Eduardo Ramires, Felix José Alvarez Alves, Silvia Marinho Martins Montera, Marcelo Westerlund Lopes, Renato Delascio Oliveira-Junior, Mucio Tavares Scolari, Fernando L. Avila, Walkiria Samuel Canesin, Manoel Fernandes Bacal, Fernando Bocchi, Edimar Alcides Moura, Lídia Ana Zytynski Saad, Eduardo Benchimol Scanavacca, Mauricio I. Valdigem, Bruno Pereira Cano , Manuel Nicolas Abizaid , Alexandre Ribeiro, Henrique Barbosa Lemos-Neto, Pedro Alves Ribeiro, Gustavo Calado de Aguiar Jatene, Fabio Biscegli Dias, Ricardo Ribeiro Beck-da-Silva, Luis Rohde, Luis Eduardo P. Bittencourt, Marcelo Imbroinise Pereira, Alexandre Krieger, José Eduardo Villacorta, Humberto Martins, Wolney de Andrade Figueiredo-Neto, José Albuquerque de Cardoso , Juliano Novaes Pastore, Carlos Alberto Jatene, Ieda Biscegli Tanaka, Ana Cristina Sayuri Hotta, Viviane Tiemi Romano, Minna Moreira Dias Albuquerque, Denilson Campos de Mourilhe-Rocha, Ricardo Hajjar, Ludhmila Abrahão Brito, Fabio Sandoli de Caramelli , Bruno Calderaro, Daniela Farsky, Pedro Silvio Colafranceschi , Alexandre Siciliano Pinto, Ibraim Masciarelli Vieira , Marcelo Luiz Campos Danzmann, Luiz Claudio Barberato , Silvio Henrique Mady, Charles Martinelli-Filho, Martino Torbey , Ana Flavia Malheiros Schwartzmann, Pedro Vellosa Macedo, Ariane Vieira Scarlatelli Ferreira , Silvia Moreira Ayub Schmidt, Andre Melo , Marcelo Dantas Tavares de Lima-Filho, Moysés Oliveira Sposito, Andrei C. Brito, Flavio de Souza Biolo, Andreia Madrini-Junior, Vagner Rizk, Stéphanie Itala Mesquita, Evandro Tinoco

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Publication date: 2024-04-08

Abstract: Pt Es En

A cardiomiopatia hipertrófica (CMH) é uma forma de doença do músculo cardíaco de causa genética, caracterizada pela hipertrofia das paredes ventriculares. O diagnóstico requer detecção por métodos de imagem (Ecocardiograma ou Ressonância Magnética Cardíaca) de qualquer segmento da parede do ventrículo esquerdo com espessura > 15 mm, sem outra causa provável. A análise genética permite identificar mutações de genes codificantes de diferentes estruturas do sarcômero responsáveis pelo desenvolvimento da CMH em cerca de 60% dos casos, permitindo o rastreio de familiares e aconselhamento genético, como parte importante do manejo dos pacientes e familiares. Vários conceitos sobre a CMH foram recentemente revistos, incluindo sua prevalência de 1 em 250 indivíduos, não sendo, portanto, uma doença rara, mas subdiagnosticada. A vasta maioria dos pacientes é assintomática. Naqueles sintomáticos, a obstrução do trato de saída do ventrículo esquerdo (OTSVE) é o principal distúrbio responsável pelos sintomas, devendo-se investigar a sua presença em todos os casos. Naqueles em que o ecocardiograma em repouso ou com Manobra de Valsalva não detecta gradiente intraventricular significativo (> 30 mmHg), devem ser submetidos à ecocardiografia com esforço físico para detecção da OTSVE.   Pacientes com sintomas limitantes e grave OTSVE, refratários ao uso de betabloqueadores e verapamil, devem receber terapias de redução septal ou uso de novas drogas inibidoras da miosina cardíaca. Por fim, os pacientes adequadamente identificados com risco aumentado de morta súbita podem receber medida profilática com implante de cardiodesfibrilador implantável (CDI).

La miocardiopatía hipertrófica (MCH) es una forma de enfermedad cardíaca de origen genético, caracterizada por el engrosamiento de las paredes ventriculares. El diagnóstico requiere la detección mediante métodos de imagen (Ecocardiograma o Resonancia Magnética Cardíaca) que muestren algún segmento de la pared ventricular izquierda con un grosor > 15 mm, sin otra causa probable. El análisis genético permite identificar mutaciones en genes que codifican diferentes estructuras del sarcómero responsables del desarrollo de la MCH en aproximadamente el 60% de los casos, lo que permite el tamizaje de familiares y el asesoramiento genético, como parte importante del manejo de pacientes y familiares. Varios conceptos sobre la MCH han sido revisados recientemente, incluida su prevalencia de 1 entre 250 individuos, por lo tanto, no es una enfermedad rara, sino subdiagnosticada. La gran mayoría de los pacientes son asintomáticos. En los casos sintomáticos, la obstrucción del tracto de salida ventricular izquierdo (TSVI) es el trastorno principal responsable de los síntomas, y su presencia debe investigarse en todos los casos. En aquellos en los que el ecocardiograma en reposo o la maniobra de Valsalva no detecta un gradiente intraventricular significativo (> 30 mmHg), deben someterse a ecocardiografía de esfuerzo para detectar la obstrucción del TSVI. Los pacientes con síntomas limitantes y obstrucción grave del TSVI, refractarios al uso de betabloqueantes y verapamilo, deben recibir terapias de reducción septal o usar nuevos medicamentos inhibidores de la miosina cardíaca. Finalmente, los pacientes adecuadamente identificados con un riesgo aumentado de muerte súbita pueden recibir medidas profilácticas con el implante de un cardioversor-desfibrilador implantable (CDI).

Hypertrophic cardiomyopathy (HCM) is a form of genetically caused heart muscle disease, characterized by the thickening of the ventricular walls. Diagnosis requires detection through imaging methods (Echocardiogram or Cardiac Magnetic Resonance) showing any segment of the left ventricular wall with a thickness > 15 mm, without any other probable cause. Genetic analysis allows the identification of mutations in genes encoding different structures of the sarcomere responsible for the development of HCM in about 60% of cases, enabling screening of family members and genetic counseling, as an important part of patient and family management. Several concepts about HCM have recently been reviewed, including its prevalence of 1 in 250 individuals, hence not a rare but rather underdiagnosed disease. The vast majority of patients are asymptomatic. In symptomatic cases, obstruction of the left ventricular outflow tract (LVOT) is the primary disorder responsible for symptoms, and its presence should be investigated in all cases. In those where resting echocardiogram or Valsalva maneuver does not detect significant intraventricular gradient (> 30 mmHg), they should undergo stress echocardiography to detect LVOT obstruction. Patients with limiting symptoms and severe LVOT obstruction, refractory to beta-blockers and verapamil, should receive septal reduction therapies or use new drugs inhibiting cardiac myosin. Finally, appropriately identified patients at increased risk of sudden death may receive prophylactic measure with implantable cardioverter-defibrillator (ICD) implantation.

https://doi.org/10.1590/SciELOPreprints.8394

What causes obesity in children and adolescents? adolescents
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Nogueira-de-Almeida, Carlos Alberto

; Weffort, Virginia Resende Silva

; Ued, Fábio da V.

; Ferraz, Ivan S.

; Contini, Andrea A.

; Martinez, Edson Zangiacomi

; Ciampo, Luiz A. Del

Jornal de Pediatria

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apr 2024, Volume 100 Suppl. 1 Pages S48 - S56

Abstract: En | Text: En | PDF: En

Abstract Objective To present the different aspects that may be involved in the genesis and maintenance of obesity in children and adolescents. Data source Narrative review of articles published in the PubMed, Scielo, Lilacs, Scopus and Google Scholar databases, using the search terms: overweight, obesity, pre-conception, prenatal, infants, schoolchildren, children, and adolescents. The search was conducted in studies written in Portuguese, English and Spanish, including narrative, integrative or systematic reviews, meta-analyses, cross-sectional, case-control and cohort studies, published between 2003 and 2023. Data synthesis A total of 598 studies were initially screened and 60 of them, which showed the main biopsychosocial aspects related to greater risks of excessive adiposity in the pediatric age, were included in the review. The data were presented taking into account the incidence of risk factors and their consequences in six periods: pre-conception, pre-natal, infant, preschool, school age, and adolescence. Conclusions The causal factors described in the scientific literature that have been shown to be related to obesity in childhood and adolescence are presented. adolescents PubMed Scielo Lilacs databases terms overweight preconception, preconception pre conception, conception pre-conception prenatal infants schoolchildren Portuguese Spanish narrative reviews metaanalyses, metaanalyses meta analyses, analyses meta-analyses crosssectional, crosssectional cross sectional, sectional cross-sectional casecontrol case control 200 2023 59 6 them age periods natal, natal pre-natal infant preschool 20 202 5 2

https://doi.org/10.1016/j.jped.2023.09.011

Effect of glyphosate management, formulations and rates on the agronomic performance of maize with the cp4epsps gene management cpepsps cp epsps
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Albrecht, Alfredo Junior Paiola

; Albrecht, Leandro Paiola

; Barroso, Arthur Arrobas Martins

; Silva, André Felipe Moreira

; Krenchinski, Fábio Henrique

; Larini, Willian Felipe

; Victoria Filho, Ricardo

Revista Ciência Agronômica

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2024, Volume 55 elocation e20228614

Abstract: En | Text: En | PDF: En

ABSTRACT Second-generation glyphosate-tolerant maize (Roundup Ready 2, RR2) is characterised by the expression of the cp4epsps gene. Despite some studies suggesting possible undesirable effects from the application of glyphosate in RR2 maize, other reports have demonstrated glyphosate selectivity for RR2 plants, with minor damage symptoms, if any, and with no negative effects on the chlorophyll indices. The aim of this study was to evaluate the effect of different types of glyphosate management, formulations and rates of application on chlorophyll indices and the agronomic performance of an RR2 maize genotype expressing the cp4epsps gene. Five experiments were conducted in a full factorial design (2 x 5 x 5) to evaluate two types of management, two formulations and five rates of glyphosate. Damage symptoms, chlorophyll indices and variables related to agronomic performance (plant height, stem diameter, yield and 100-grain weight) were evaluated. Similar crop responses were found for each of the glyphosate formulations (potassium salt and isopropylamine salt) and types of management (single application and sequential application) under test, indicating that the use of glyphosate-based commercial products affords flexibility in terms of formulation and frequency of application. Glyphosate formulated as potassium salt or isopropylamine salt and applied to RR2 maize either in a single application (full rate) or in two sequential applications (each at half rate) has a similar effect and may therefore be used without distinction. However, it is important to consider the rate of application since high rates of glyphosate (especially greater than 1,440 g ae ha-1) may affect the development and production of RR2 maize. Secondgeneration Second generation glyphosatetolerant tolerant Roundup 2 RR cpepsps cp epsps gene plants symptoms any ( plant height diameter 100grain grain 100 weight evaluated test glyphosatebased based distinction However especially 1440 1 440 1,44 ha1 ha ha-1 10 144 44 1,4 ha- 14 4 1,

https://doi.org/10.5935/1806-6690.20240013

Translation, cross-cultural adaptation, and validation of health and self-management in diabetes questionnaire (HASMID-10) into Brazilian Portuguese Translation crosscultural cross cultural adaptation selfmanagement self management HASMID10 HASMID 10 (HASMID-10 HASMID1 1 (HASMID-1 (HASMID- (HASMID
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Santos-de-Araújo, Aldair Darlan

; Dibai-Filho, Almir Vieira

; Pontes-Silva, André

; Rêgo, Adriana Sousa

; Santos, Dalyla Lima dos

; Mendes Júnior, Abraão Albino

; Pereira, Fábio Henrique Ferreira

; Bacelar, Solange Negreiros de Almeida

; Oliveira, Bárbara Emanoele Costa

; Tavarez, Rudys Rodolfo de Jesus

; Bassi-Dibai, Daniela

Sao Paulo Medical Journal

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2024, Volume 142 N. 1 elocation e2022681

Abstract: En | Text: En | PDF: En

ABSTRACT BACKGROUND: Considering the ability of the health and self-management in diabetes questionnaire (HASMID-10) to verify the impact of self-management on diabetes, we highlight its relevance to scientific research and clinical applicability. However, to date, no study has been conducted to scientifically support its use in other languages. OBJECTIVE: To translate, cross-culturally adapt, and validate the HASMID-10 into the Brazilian Portuguese. DESIGN AND SETTING: A translation, cross-cultural adaptation, and validation study conducted at Ceuma University. METHODS: Study was conducted in accordance with the Guidelines for the Process of Cross-Cultural Adaptation of Self-Report Measures and Consensus-based Standards for the Selection of Health Measurement Instruments. We included participants of both sexes diagnosed with diabetes, aged between 18 and 64 years, and without cognitive deficits or any other limitations that would prevent them from answering the questionnaire. We assessed participants using the problem areas in diabetes (PAID) scale and HASMID-10. We assessed reliability using a test-retest model with a 7-day interval between assessments. We used intraclass correlation coefficient (ICC), 95% confidence interval (CI), standard error of measurement (SEM), minimum detectable difference (MDD), Spearman correlation coefficient, and floor and ceiling effects. RESULTS: Sample comprised 116 participants, most of whom were women, overweight, non-practitioners of physical activity, and nonsmokers. We observed significant correlations (P = 0.006; rho = −0.256) between the HASMID-10 and PAID, adequate reliability (ICC = 0.780) and internal consistency (Cronbach's alpha = 0.796). No ceiling or floor effects were observed. CONCLUSION: HASMID-10 has adequate measurement properties and may be used for Brazilians. BACKGROUND selfmanagement self management HASMID10 HASMID 10 (HASMID-10 applicability However date languages OBJECTIVE translate crossculturally cross culturally adapt HASMID-1 Portuguese SETTING translation crosscultural cultural adaptation University METHODS CrossCultural Cross Cultural SelfReport Self Report Consensusbased Consensus based Instruments 1 6 years PAID (PAID HASMID10. 10. testretest test retest 7day day 7 assessments ICC, ICC , (ICC) 95 CI, CI (CI) SEM, SEM (SEM) MDD, MDD (MDD) RESULTS 11 women overweight nonpractitioners non practitioners activity nonsmokers P 0.006 0006 0 006 −0.256 0256 256 0.780 0780 780 Cronbachs Cronbach s 0.796. 0796 0.796 . 796 0.796) CONCLUSION Brazilians HASMID1 (HASMID-1 HASMID- 9 (CI (SEM (MDD 0.00 000 00 −0.25 025 25 0.78 078 78 079 0.79 79 (HASMID- 0.0 −0.2 02 2 0.7 07 (HASMID 0. −0. −0 −

https://doi.org/10.1590/1516-3180.2022.0681.r1.10042023

Vacinar ou arriscar? A mensagem da Organização Mundial de Saúde para promover a vacinação contra a covid-19
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Silva, Sónia

; Araújo, Diogo da Silva

; Ribeiro, Fábio

; Araújo, Catarina Silva

Saúde e Sociedade

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2024, Volume 33 N. 1 elocation e220584pt

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Focusing on the impact that risk communication issued by public health organizations brings to changing societal behaviors, this research aimed to analyze the key messages that the World Health Organization (WHO) has defined to promote the COVID-19 vaccination program. In order to achieve this goal, a qualitative study methodology was used to analyze the content published on the WHO’s Facebook and Instagram pages from April 1 to August 31, 2021. In total, 62 publications were analyzed. The results showed that the WHO used four key communication messages to promote the importance of vaccination in society: ensuring the credibility and transparency of the information transmitted; certifying the safety and efficacy of the vaccine; appealing to a sense of collective responsibility; and associating the vaccine with the solution to end the pandemic were the chosen communication axes. The conclusions of this study show that, although fair access to the vaccine is still a reality in the making, the fact that almost 70% of the world’s population has been vaccinated suggests that the messages sent by the WHO in the context of risk communication may have contributed to building a positive image of the vaccination program.

Resumo Centrando-se no impacto que a comunicação de risco emitida pelas organizações de saúde pública tem na mudança dos comportamentos da sociedade, esta investigação pretende analisar as mensagens-chave que a Organização Mundial de Saúde (OMS) definiu para promover o programa de vacinação contra a covid-19. Para cumprir este objetivo, enveredou-se por uma metodologia de estudo qualitativa, que privilegiou o uso da análise do conteúdo publicado nas páginas de Facebook e de Instagram da OMS, no período de 1 de abril a 31 de agosto de 2021. No total, foram analisadas 62 publicações. Os resultados mostraram que a OMS utilizou quatro eixo de comunicação para promover a importância da vacinação na sociedade: garantir a credibilidade e a transparência da informação transmitida; certificar a segurança e a eficácia da vacina; apelar ao sentido de responsabilidade coletiva; e associar a vacina à solução para pôr fim à pandemia. As conclusões do estudo mostram que, embora a equidade no acesso à vacina ainda seja uma realidade em construção, os quase 70% da população mundial vacinada sugerem que as mensagens enviadas pela OMS no contexto de comunicação de risco podem ter contribuído para a construção de uma imagem positiva do programa de vacinação.

https://doi.org/10.1590/s0104-12902024220584pt

Cosmiatry: An analysis of the Brazilian market Cosmiatry
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NASCIMENTO JUNIOR, BARTOLOMEU ANTONIO

; MOTTA, FLáVIO JOSé TEIXEIRA ROCHA ATAíDE DA

; SILVA, FERNANDA AUGUSTA SIQUEIRA-CAMPOS FERREIRA DA

; DIAS-NEVES, FáBIO

; TORREãO, GUILHERME

; ANLICOARA, RAFAEL

Revista Brasileira de Cirurgia Plástica

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2024, Volume 39 N. 1 elocation e0814

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

■ RESUMO Introdução: O mercado de procedimento estéticos cresce exponencialmente no Brasil. Tal crescimento tem despertado o interesse de várias categorias profissionais. A decisão de praticar no setor deve considerar as oportunidades de mercado da localidade na qual se pretende atuar. Entretanto, a área carece de análises comparativas documentando prováveis diferenças regionais no país. O objetivo do estudo é descrever as diferenças de mercado em procedimentos estéticos entre os estados e regiões brasileiras. Um índice de potencial consumo de cosmiatria (IPCC) é calculado para tal análise comparativa. Método: Estudo transversal envolvendo prestadores de procedimentos estéticos não cirúrgicos no Brasil. Buscas no Google®-Google Maps® foram conduzidas usando termos-chave e entrevistas telefônicas realizadas para obter informações sobre categorias profissionais, tipo de provedores e serviços oferecidos. Valores preditivos positivos foram obtidos para todas as estratégias de busca e usados para estimar o número total de provedores. O tamanho da população e a renda per capita foram considerados para o cálculo dos IPCCs para os estados brasileiros. Resultados: São Paulo, Minas Gerais e Rio de Janeiro apresentaram os maiores IPCCs, sendo 524, 210 e 180, respectivamente. Roraima teve um IPCC de 14, o mais baixo do país. A Região Sudeste apresentou, em média, o maior IPCC (242) entre todas as regiões brasileiras. Conclusão: Considerando o tamanho da população e a renda, a Região Sudeste apresenta as maiores oportunidades de mercado em procedimentos estéticos não cirúrgicos no Brasil. Nossos achados podem ser de interesse para profissionais de saúde e investidores que atuam ou pretendem atuar no setor. Introdução Brasil Entretanto país brasileiras (IPCC comparativa Método Google®Google GoogleGoogle Google® Google Maps termoschave termos chave oferecidos brasileiros Resultados Paulo 524 21 180 respectivamente 14 apresentou média 242 (242 Conclusão 52 2 18 1 24 (24 5 (2 (

■ ABSTRACT Introduction: The aesthetic procedure market is growing exponentially in Brazil. This growth has aroused the interest of several professional categories. The decision to practice in the sector must consider the market opportunities in the location in which you intend to operate. However, the area lacks comparative analyses documenting probable regional differences in the country. The objective of the study is to describe market differences in aesthetic procedures between Brazilian states and regions. An index of potential cosmetic consumption (IPCC) is calculated for such a comparative analysis. Method: Cross-sectional study involving providers of nonsurgical aesthetic procedures in Brazil. Searches on Google Maps® were conducted using key terms, and telephone interviews were conducted to obtain information on professional categories, types of providers, and services offered. Positive predictive values were obtained for all search strategies and used to estimate the total number of providers. Population size and per capita income were considered to calculate the IPCCs for Brazilian states. Results: São Paulo, Minas Gerais, and Rio de Janeiro presented the highest IPCCs, being 524, 210, and 180, respectively. Roraima had an IPCC of 14, the lowest in the country. The Southeast Region presented, on average, the highest IPCC (242) among all Brazilian regions. Conclusion: Considering population size and income, the Southeast Region presents the greatest market opportunities for nonsurgical aesthetic procedures in Brazil. Our findings may be of interest to healthcare professionals and investors who work or intend to work in the sector. Introduction Brazil categories operate However country regions (IPCC analysis Method Crosssectional Cross sectional Maps terms offered Results Paulo Gerais 524 210 180 respectively 14 average 242 (242 Conclusion 52 21 18 1 24 (24 5 2 (2 (

https://doi.org/10.5935/2177-1235.2023rbcp0814-en

Hospitalization and mortality rates of malignant prostatic neoplasms in Brazil: A cross-sectional study from 2008 to 2018 Brazil crosssectional cross sectional 200 201 20 2
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Justo, Alberto Fernando Oliveira

; Collaço, Rita de Cássia

; Soares, Anna Ligia Oenning

; Caloi, Caroline Marques

; Estancial, Camila Stefani

; Lemos, Guilherme

; Silva, Fabio Henrique da

; Alexandre, Eduardo Costa

; Calmasini, Fabiano Beraldi

Brazilian Journal of Pharmaceutical Sciences

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2024, Volume 60 elocation e23366

Abstract: En | Text: En | PDF: En

Abstract Prostate cancer (PCa) is a highly prevalent condition among men worldwide, resulting in reduced quality of life and increased costs to health systems due to hospitalization and death. This study aimed to explore and understand the evolution of PCa in Brazil from 2008 to 2018. Data were obtained from the National Health System Department of Informatics (DATASUS) using code C61 for malignant prostatic neoplasms. We presented the hospitalization and mortality rates in a temporal-, regional- and age-dependent manner. From 2008 to 2018, a year-dependent increase in hospital admissions due to PCa was reported in Brazil, in which the Southeast region showed the highest prevalence. Men aged ≥80 and those 70-79 years old had similar hospitalization rates, followed by men aged 60-69, 50-59, 40-49 and 30-39 years old. Similarly, an increase in deaths due to PCa was reported during this period, with the highest rates seen in the Southeast. Men aged ≥80 years had higher mortality rates, followed by those aged 70-79, 60-69, 50-59, 40-49 and 30-39 years old. The results obtained indicate an age- and region-dependent increase in PCa morbidity and mortality in Brazil overtime and may contribute to the ongoing discussion on the role and future perspective of the health care system in Brazil. (PCa worldwide death 200 2018 DATASUS (DATASUS C C6 neoplasms temporal, temporal , temporal- regional agedependent age dependent manner yeardependent year prevalence 80 ≥8 7079 70 79 70-7 6069, 6069 60 69, 69 60-69 5059, 5059 50 59, 59 50-59 4049 40 49 40-4 3039 30 39 30-3 Similarly period 7079, 79, regiondependent 20 201 8 ≥ 707 7 70- 606 6 60-6 505 5 50-5 404 4 40- 303 3 30- 2 60- 50-

https://doi.org/10.1590/s2175-97902024e23366

Elevada expressão de galectina-3 em cicatrizes excessivas: Um estudo piloto galectina3 galectina 3 galectina- excessivas
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FERREIRA, VICTOR FREIRE SALOMÃO

; LEMOS, FELIPE SIMÕES

; RIBEIRO, ROBERTO STEFAN DE ALMEIDA

; DE-ARAÚJO, SILVIO RENAN PINHEIRO VICTOR

; FIGUEREDO, FABIO SANTIAGO

; SILVA, MARIA LIDIA DE ABREU

; DE-OLIVEIRA, FELIPE LEITE

; AMADEU, THAÍS PORTO

Revista Brasileira de Cirurgia Plástica

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2024, Volume 39 N. 3 elocation e0936

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: Cicatrizes hipertróficas e queloides são tipos de cicatrizes excessivas de cicatrização anormal da pele. Galectina-3 (gal-3) é uma proteína da família das lectinas capaz de identificar carboidratos, que podem se combinar e atuar em diversas moléculas. Na literatura, a ação da gal-3 como principal agente regulador da fibrogênese já foi descrita, sendo atualmente utilizada na terapia antifibrótica de diversos órgãos como pulmão e fígado. O objetivo deste estudo piloto foi mostrar resultados preliminares encontrados na expressão de gal-3 em cicatrizes exacerbadas. Método: Foram coletadas 20 amostras de biópsias de cicatrizes excessivas (16 queloides e 4 cicatrizes hipertróficas) e 9 amostras de cicatrizes normais de 22 mulheres e 7 homens. Essas amostras foram processadas para análise histopatológica de rotina por imuno-histoquímica para detectar gal-3. As células positivas para gal-3 foram quantificadas pelo método estereológico utilizando uma grade de 36 pontos. Resultados: A imuno-histoquímica mostrou alta expressão de gal-3 em células endoteliais e epiteliais de todas as amostras de cicatrizes, bem como expressão em células distribuídas pela derme. Maior expressão de gal-3 foi encontrada em amostras de queloides (28% de células positivas) em comparação com cicatrizes normais (18%) e hipertróficas (22%) (p = 0,0075). Os resultados foram obtidos de um pequeno número de pacientes, por se tratar de um estudo piloto. Conclusão: Os dados sugerem que a gal-3 participa do processo de cicatrização e, devido à sua maior presença em amostras de queloides, pode ser um potencial biomarcador para formação de queloides e um alvo terapêutico promissor a ser explorado. Introdução pele Galectina3 Galectina 3 Galectina- gal3 gal (gal-3 carboidratos moléculas literatura gal- descrita fígado exacerbadas Método 2 16 (1 homens imunohistoquímica imuno histoquímica gal3. 3. pontos Resultados derme 28% 28 (28 18% 18 (18% 22% (22% p 0,0075. 00075 0,0075 . 0 0075 0,0075) pacientes Conclusão explorado (gal- 1 ( (2 (18 (22 0007 0,007 007 (gal 000 0,00 00 0,0 0,

ABSTRACT Introduction: Hypertrophic scars and keloids are types of excessive scars from abnormal skin healing. Galectin-3 (gal-3) is a protein from the lectin family capable of identifying carbohydrates, which can combine and act on different molecules. In the literature, the action of gal-3 as the main regulatory agent of fibrogenesis has already been described and is currently used in anti-fibrotic therapy for various organs such as the lung and liver. The objective of this pilot study was to show preliminary results found in the expression of gal-3 in exacerbated scars. Method: Twenty biopsy samples from excessive scars (16 keloids and 4 hypertrophic scars) and 9 samples from normal scars were collected from 22 women and 7 men. These samples were processed for routine histopathological analysis by immunohistochemistry to detect gal-3. Gal-3 positive cells were quantified by the stereological method using a 36-point grid. Results: Immunohistochemistry showed high expression of gal-3 in endothelial and epithelial cells of all scar samples, as well as expression in cells distributed throughout the dermis. Higher gal-3 expression was found in keloid samples (28% positive cells) compared to normal (18%) and hypertrophic (22%) scars (p = 0.0075). The results were obtained from a small number of patients, as this was a pilot study. Conclusion: The data suggest that gal-3 participates in the healing process and, due to its greater presence in keloid samples, it may be a potential biomarker for keloid formation and a promising therapeutic target to be explored. Introduction Galectin3 Galectin 3 Galectin- gal3 gal (gal-3 carbohydrates molecules literature gal- antifibrotic anti fibrotic liver Method 16 (1 2 men gal3. 3. Gal3 Gal Gal- 36point point 36 grid Results dermis 28% 28 (28 18% 18 (18% 22% (22% p 0.0075. 00075 0.0075 . 0 0075 0.0075) patients Conclusion explored (gal- 1 ( (2 (18 (22 0007 0.007 007 (gal 000 0.00 00 0.0 0.

https://doi.org/10.5935/2177-1235.2024rbcp0936-pt

10.

Brazilian consensus recommendations on the diagnosis and treatment of autoimmune encephalitis in the adult and pediatric populations
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Dutra, Lívia Almeida

; Silva, Pedro Victor de Castro

; Ferreira, João Henrique Fregadolli

; Marques, Alexandre Coelho

; Toso, Fabio Fieni

; Vasconcelos, Claudia Cristina Ferreira

; Brum, Doralina Guimarães

; Pereira, Samira Luisa dos Apóstolos

; Adoni, Tarso

; Rocha, Leticia Januzi de Almeida

; Sampaio, Leticia Pereira de Brito

; Sousa, Nise Alessandra de Carvalho

; Paolilo, Renata Barbosa

; Pizzol, Angélica Dal

; Costa, Bruna Klein da

; Disserol, Caio César Diniz

; Pupe, Camila

; Valle, Daniel Almeida do

; Diniz, Denise Sisterolli

; Abrantes, Fabiano Ferreira de

; Schmidt, Felipe da Rocha

; Cendes, Fernando

; Oliveira, Francisco Tomaz Meneses de

; Martins, Gabriela Joca

; Silva, Guilherme Diogo

; Lin, Katia

; Pinto, Lécio Figueira

; Santos, Mara Lúcia Schimtz Ferreira

; Gonçalves, Marcus Vinícius Magno

; Krueger, Mariana Braatz

; Haziot, Michel Elyas Jung

; Barsottini, Orlando Graziani Povoas

; Nascimento, Osvaldo José Moreira do

; Nóbrega, Paulo Ribeiro

; Proveti, Priscilla Mara

; Castilhos, Raphael Machado do

; Daccach, Vanessa

; Glehn, Felipe von

Arquivos de Neuro-Psiquiatria

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2024, Volume 82 N. 7 elocation s00441788586

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Antecedentes Encefalites autoimunes (EAIs) são um grupo de doenças inflamatórias caracterizadas pela presença de anticorpos contra antígenos neuronais e gliais, que ocasionam sintomas psiquiátricos subagudos, queixas de memória e distúrbios anormais do movimento. A maioria dos pacientes é jovem, e o atraso no tratamento está associado a pior prognóstico. Objetivo Com o apoio da Academia Brasileira de Neurologia (ABN) e da Sociedade Brasileira de Neurologia Infantil (SBNI), desenvolvemos um consenso sobre o diagnóstico e o tratamento da EAIs no Brasil utilizando a metodologia Delphi. Métodos Um total de 25 especialistas, incluindo neurologistas e neurologistas infantis, foram convidados a participar. Resultados Os especialistas concordaram que os pacientes com critérios de possíveis EAIs devem ser submetidos ao rastreio de anticorpos antineuronais no soro e no líquido cefalorraquidiano (LCR) por meio das técnicas de ensaio baseado em tecidos (tissue-based assay, TBA, em inglês) e ensaio baseado em células (cell-based assay, CBA, em inglês). As crianças também devem ser submetidas ao rastreio de de anticorpo contra a glicoproteína da mielina de oligodendrócitos (anti-myelin oligodendrocyte glycoprotein, anti-MOG, em inglês). O tratamento deve ser iniciado dentro das primeiras 4 semanas dos sintomas, sendo as opções de primeira linha metilprednisolona combinada com imunoglobulina intravenosa (IGIV) ou plasmaférese. O tratamento de segunda linha inclui rituximabe e ciclofosfamida. Bortezomib e tocilizumab são opções de tratamento de terceira linha. A maioria das crises epilépticas nas EAIs são sintomáticas, e os fármacos anticrise podem ser desmamadas após a fase aguda. Em relação à encefalite antirreceptor de N-metil-D-aspartato (anti-N-methyl-D-aspartate receptor, anti-NMDAR, em inglês), os especialistas concordaram que agentes imunossupressores orais não devem ser usados. Os pacientes devem ser avaliados na fase aguda e pós-aguda mediante escalas funcionais e cognitivas, como Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Modified Rankin Scale (mRS), e Clinical Assessment Scale in Autoimmune Encephalitis (CASE). Conclusão Esta pesquisa oferece evidências tangíveis do manejo efetivo de pacientes com EAIs no sistema de saúde Brasileiro. (EAIs gliais subagudos movimento jovem prognóstico ABN (ABN SBNI, SBNI , (SBNI) Delphi 2 infantis participar LCR (LCR tissuebased tissue based assay TBA inglês cellbased cell CBA inglês. . antimyelin anti myelin glycoprotein antiMOG, antiMOG MOG, MOG anti-MOG IGIV (IGIV plasmaférese ciclofosfamida sintomáticas NmetilDaspartato N metil D aspartato antiNmethylDaspartate methyl aspartate receptor antiNMDAR, antiNMDAR NMDAR, NMDAR anti-NMDAR inglês, usados pósaguda pós cognitivas MiniMental Mini Mental MMSE, MMSE (MMSE) MoCA, MoCA (MoCA) mRS, mRS (mRS) CASE. CASE (CASE) Brasileiro (SBNI (MMSE (MoCA (mRS (CASE

Abstract Background Autoimmune encephalitis (AIE) is a group of inflammatory diseases characterized by the presence of antibodies against neuronal and glial antigens, leading to subacute psychiatric symptoms, memory complaints, and movement disorders. The patients are predominantly young, and delays in treatment are associated with worse prognosis. Objective With the support of the Brazilian Academy of Neurology (Academia Brasileira de Neurologia, ABN) and the Brazilian Society of Child Neurology (Sociedade Brasileira de Neurologia Infantil, SBNI), a consensus on the diagnosis and treatment of AIE in Brazil was developed using the Delphi method. Methods A total of 25 panelists, including adult and child neurologists, participated in the study. Results The panelists agreed that patients fulfilling criteria for possible AIE should be screened for antineuronal antibodies in the serum and cerebrospinal fluid (CSF) using the tissue-based assay (TBA) and cell-based assay (CBA) techniques. Children should also be screened for anti-myelin oligodendrocyte glucoprotein antibodies (anti-MOG). Treatment should be started within the first 4 weeks of symptoms. The first-line option is methylprednisolone plus intravenous immunoglobulin (IVIG) or plasmapheresis, the second-line includes rituximab and/or cyclophosphamide, while third-line treatment options are bortezomib and tocilizumab. Most seizures in AIE are symptomatic, and antiseizure medications may be weaned after the acute stage. In anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, the panelists have agreed that oral immunosuppressant agents should not be used. Patients should be evaluated at the acute and postacute stages using functional and cognitive scales, such as the Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA), the Modified Rankin Scale (mRS), and the Clinical Assessment Scale in Autoimmune Encephalitis (CASE). Conclusion The present study provides tangible evidence for the effective management of AIE patients within the Brazilian healthcare system. (AIE antigens symptoms complaints disorders young prognosis Academia ABN Sociedade Infantil SBNI, SBNI , SBNI) method 2 neurologists CSF (CSF tissuebased tissue based TBA (TBA cellbased cell CBA (CBA techniques antimyelin anti myelin antiMOG. antiMOG MOG . (anti-MOG) firstline line IVIG (IVIG plasmapheresis secondline second andor cyclophosphamide thirdline third tocilizumab symptomatic stage antiNmethylDaspartate N methyl D aspartate antiNMDAR NMDAR (anti-NMDAR used scales MiniMental Mini Mental MMSE, MMSE (MMSE) MoCA, MoCA (MoCA) mRS, mRS (mRS) CASE. CASE (CASE) system (anti-MOG (MMSE (MoCA (mRS (CASE

https://doi.org/10.1055/s-0044-1788586

11.

RHCE and Kell genotyping and alloimmunization profile in patients with sickle cell disease in the Federal District of Brazil
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Leite, Larissa Espíndola

; Silva, Fábio Gonçalves da

; Kashima, Simone

; Rodrigues, Evandra Strazza

; Haddad, Rodrigo

Hematology, Transfusion and Cell Therapy

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2024, Volume 46 N. 3 Pages 261 - 267

Abstract: En | Text: En | PDF: En

Abstract Introduction Sickle cell disease (SCD) is the most important hemoglobinopathy worldwide. The treatment often requires phenotype-matched red blood cell (RBC) transfusions, but alloimmunization to non-ABO antigens may occur in a part of the SCD patients. The genotyping has been used for RBC antigen prediction, reducing the possibility of the alloimmunization. Objective and Method In this study we performed the genotyping for the Kell and RHCE blood groups in samples from 77 phenotyped Brazilian SCD patients, whose alloimmunization profiles were also assessed. Results Discrepancies between genotyping and phenotyping for the RHCE and Kell blood groups systems were observed in 22.07% (17/77) of the SCD patients. We found C/c and E/e discrepancies in 11.68% and 9.09% of patients, respectively; one SCD patient (1.3%) presented a discrepancy in the Kell group. Two SCD patients with discrepancies between genotype and phenotype were alloimmunized. In total, twenty-eight patients (36.4%) developed alloantibodies, of which 55.17% were directed against antigens in the Rh system, 8.62% were directed against antigens in the Kell system and 36.20%, against other groups. Finally, the frequency of discrepancies is significantly higher in non-alloimmunized patients (30.61%), compared to alloimmunized patients (7.14%) (p = 0.0217). Conclusion In part, the alloimmunization of the SCD patients may have been triggered by these discrepancies, indicating that the integration of serological and molecular tests in the immunohematology routine could help to increase the transfusion safety. However, the higher number of alloimmunized patients without discrepancies showed that reasons other than the discrepancies appear to have influenced more strongly the alloimmunization in the SCD patients in this study. (SCD worldwide phenotypematched matched (RBC transfusions nonABO non ABO prediction 7 assessed 2207 22 07 22.07 17/77 1777 17 (17/77 Cc C c Ee E e 1168 11 68 11.68 909 9 09 9.09 respectively 1.3% 13 1 3 (1.3% group total twentyeight twenty eight 36.4% 364 36 4 (36.4% alloantibodies 5517 55 55.17 862 8 62 8.62 3620 20 36.20% Finally nonalloimmunized 30.61%, 3061 30.61% , 30 61 (30.61%) 7.14% 714 14 (7.14% p 0.0217. 00217 0.0217 . 0 0217 0.0217) safety However 220 2 22.0 17/7 177 (17/7 116 6 11.6 90 9.0 1.3 (1.3 36.4 (36.4 551 5 55.1 86 8.6 362 36.20 306 30.61 (30.61% 7.14 71 (7.14 0021 0.021 021 22. 17/ (17/ 11. 9. 1. (1. 36. (36. 55. 8. 36.2 30.6 (30.61 7.1 (7.1 002 0.02 02 (17 (1 (36 30. (30.6 7. (7. 00 0.0 ( (3 (30. (7 0. (30

https://doi.org/10.1016/j.htct.2023.05.004

12.

Toposequence: What are we talking about? Toposequence about
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Alves, Grace Bungenstab

; Oliveira, Fábio Soares de

; Silva, Artur Henrique Nascimento da

; Souza Junior, Valdomiro Severino de

Revista Brasileira de Ciência do Solo

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2024, Volume 48 elocation e0230137

Abstract: En | Text: En | PDF: En

ABSTRACT The term toposequence, proposed to designate a lateral succession of soils on a slope due to the influence of topography, began to be used differently over time, distancing itself from its original concept. Here, we discuss how this concept has been used since its inception. We carried out bibliometric analyses of publications in the database available on the Web of Science since 1900. Three main approaches and related concepts, explicit or not, one at a regional scale and two others at a local scale were identified. From this analysis, we suggest: a) when the approach is regional, the term geomorphic surface or position in the landscape should be used to address the spatial distribution and genetic implications of soils at this scale; b) when dealing with series/sequences of soils on slopes for mapping purposes or discontinuous profiles that emphasize taxonomic classification, the term catena should be used; c) when the determining factor of the soil sequence is climatic, biotic, lithological, chronological, the corresponding term climo-, bio-, litho- or chronosequence should be used; d) when dealing with a lateral succession of horizons in the continuum on slopes, resulting from the influence of topography on soil formation, which may reflect the soil contribution to the model evolution, only in this case should the term toposequence be used, returning to its original concept. time Here inception 1900 concepts not identified analysis suggest b seriessequences series sequences classification c climatic biotic lithological chronological climo, climo , climo- bio, bio bio- litho d formation evolution 190 19 1

https://doi.org/10.36783/18069657rbcs20230137

13.

Vacinar ou arriscar? A mensagem da Organização Mundial de Saúde para promover a vacinação contra a covid-19 arriscar covid19 covid 19 covid-1 covid1 1 covid-
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Silva, Sónia

; Araújo, Diogo da Silva

; Ribeiro, Fábio

; Araújo, Catarina Silva

Saúde e Sociedade

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2024, Volume 33 N. 1 elocation e220584pt

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/s0104-12902024220584pt

14.

Boron nutrition improves peanuts yield and seed quality in a low B sandy soil
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Cordeiro, Carlos Felipe dos Santos

; Galdi, Leonardo Vesco

; Silva, Gustavo Ricardo Aguiar

; Custodio, Ceci Castilho

; Echer, Fábio Rafael

Revista Brasileira de Ciência do Solo

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2024, Volume 48 elocation e0230043

Abstract: En | Text: En | PDF: En

ABSTRACT Peanuts are mainly grown in sandy soils with low boron content, which may limit the crop yield, especially runner-type cultivars that have high-yields. Boron deficiency causes hollow heart in peanut seeds, reducing yield and seed quality, but the best strategy to supply boron to peanut is still not known. This study aimed to evaluate peanuts nutrition, yield, and seed quality as a function of boron rate, source, and application form. The study was conducted for two years in sandy soils with low boron in southeastern Brazil. Treatments included application of boron via soil: control (boron unfertilized), boric acid at 1.5 kg ha-1 of B, Ulexite (1.5 and 3.0 kg ha-1 of B), and sodium tetraborate (1.5 and 3.0 kg ha-1 of B) combined with foliar fertilization (sub-plots): 0, 400, 800 and 1200 g ha-1 of B (boric acid) with four replicates. Boron fertilization via soil and foliar increased peanuts yield by 20 % (1100 kg ha-1) and 14 % (700 kg ha-1) - the average of the two crops, respectively. Combined use of soil and foliar fertilizer was justified only in years with water deficit and when the rate applied via soil was low (<3.0 kg ha-1). Boron application via soil or application of 400 g ha-1 of B via foliar fertilization increased seed germination rate by 10 to 13 %. Boron fertilization increased the percentage of normal seedlings, seedling weight, and length and reduced the germination time. Foliar and soil boron applications efficiently improved peanut seed nutrition, yield, and quality. However, soil application performed better, showing a higher percentage of yield increase. content runnertype runner type highyields. highyields high yields. yields high-yields seeds known nutrition source form Brazil unfertilized, unfertilized , unfertilized) 15 1 5 1. ha1 ha ha- (1. 30 3 0 3. subplots sub plots (sub-plots) 80 120 replicates 2 1100 (110 700 (70 crops respectively <3.0 (<3. ha1. . 40 seedlings weight time However better increase (1 (sub-plots 8 12 110 (11 70 (7 <3. (<3 4 ( 11 7 <3 (< <

https://doi.org/10.36783/18069657rbcs20230043

15.

Anormalidades Cardíacas nas Síndromes Hipereosinofílicas
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Hotta, Viviane Tiemi

; Nastari, Rafael Ruas

; Oishi, Gardênia da Silva Lobo

; Kayano, Alexandre Eiji

; Oliveira, Juliana Alzira Gonzales

; Rocha, Ruiza Gonçalves

; Mocumbi, Ana Olga

; Seguro, Fernanda Salles

; Krieger, José Eduardo

; Fernandes, Fábio

; Salemi, Vera Maria Cury

Arquivos Brasileiros de Cardiologia

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2024, Volume 121 N. 10 elocation e20240190

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A Hipereosinofilia (HE) é definida como uma contagem de eosinófilos superior a 1500 células/microL no sangue periférico em dois exames, realizados com intervalo mínimo de um mês e/ou confirmação anatomopatológica de HE, com eosinófilos compreendendo mais de 20% de todas as células nucleadas da medula óssea. A Síndrome hipereosinofílica (SHE) indica a presença de HE com comprometimento de órgãos por ação eosinofílica, podendo ser classificada como primária (ou neoplásica), secundária (ou reativa) e idiopática. O comprometimento cardíaco ocorre em até 5% dos casos na fase aguda e em 20% na fase crônica da doença, variando de casos oligossintomáticos até miocardite aguda fulminante ou cardiomiopatia restritiva crônica (endomiocardite de Loeffler). No entanto, o grau de disfunção cardíaca não se correlaciona diretamente com o grau de eosinofilia. O envolvimento cardíaco na SHE ocorre em três fases: necrótica inicial, trombótica e necrótica final. Pode se manifestar como insuficiência cardíaca, arritmias e fenômenos tromboembólicos. O diagnóstico de cardiopatia é baseado em métodos de imagem multimodalidade, com ênfase na importância do ecocardiograma transtorácico (ETT). Em pacientes com janela acústica limitada, podem ser utilizados agentes de contraste ultrassonográfico, que permitem melhor visualização das bordas endocárdicas e da região ventricular apical. Técnicas para análise da deformação miocárdica podem evidenciar redução do strain em segmentos apicais e preservação nos demais segmentos (reverse apical sparing). A ressonância magnética cardíaca permite a caracterização do realce tardio subendocárdico de gadolínio, e a biópsia endomiocárdica é considerada o padrão ouro no diagnóstico de cardiopatia. O tratamento é baseado na etiologia da SHE. (HE 150 célulasmicroL microL exames eou 20 óssea (SHE eosinofílica neoplásica, neoplásica , neoplásica) reativa idiopática 5 doença endomiocardite Loeffler. Loeffler . Loeffler) entanto eosinofilia fases inicial final tromboembólicos multimodalidade ETT. ETT (ETT) limitada ultrassonográfico reverse sparing. sparing sparing) gadolínio 15 2 (ETT 1

Abstract Hypereosinophilia (HE) is defined as an eosinophil count exceeding 1500 cells/microL in peripheral blood in two tests, performed with an interval of at least one month and/or anatomopathological confirmation of HE, with eosinophils comprising more than 20% of all nucleated cells in the bone marrow. Hypereosinophilic syndrome (HES) indicates the presence of HE with organ involvement due to eosinophil action, which can be classified as primary (or neoplastic), secondary (or reactive), and idiopathic. Cardiac involvement occurs in up to 5% of cases in the acute phase and 20% of the chronic phase of the disease, ranging from oligosymptomatic cases to fulminant acute myocarditis or chronic restrictive cardiomyopathy (Loeffler endomyocarditis). However, the degree of cardiac dysfunction does not directly correlate with the degree of eosinophilia. The cardiac involvement of HES occurs in three phases: initial necrotic, thrombotic, and finally necrotic. It can manifest as heart failure, arrhythmias, and thromboembolic phenomena. The diagnosis of cardiopathy is based on multimodality imaging, with an emphasis on the importance of echocardiography (echo) as the primary examination. TTE with enhanced ultrasound agents can be used for better visualization, allowing greater accuracy in assessing ventricular apex, and myocardial deformation indices, such as longitudinal strain, may be reduced, especially in the ventricular apex (reverse apical sparing). Cardiac magnetic resonance imaging allows the characterization of subendocardial late gadolinium enhancement, and endomyocardial biopsy is considered the gold standard in diagnosing cardiopathy. Treatment is based on the etiology of HES. (HE 150 cellsmicroL microL tests andor 20 marrow (HES action neoplastic, neoplastic , neoplastic) reactive, reactive reactive) idiopathic 5 disease Loeffler endomyocarditis. endomyocarditis . endomyocarditis) However eosinophilia phases necrotic thrombotic failure arrhythmias phenomena echo (echo examination visualization indices strain reduced reverse sparing. sparing sparing) enhancement 15 2 1

https://doi.org/10.36660/abc.20240190

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Glossary and search help

You can enrich your search in a very simple way. Use the search indexes combined with the connectors (AND or OR) and specify more your search.

For example, if you want to search for articles about
cases of dengue in Brasil in 2015, use:
ti:dengue and publication_year:2015 and aff_country:Brasil

See below the complete list of search indexes that can be used:

Index code	Element
ti	article title
au	author
kw	article keywords
subject	subject (title words, abstract and keywords)
ab	abstract
ta	journal short title (e.g. Cad. Saúde Pública)
journal_title	journal full title (e.g. Cadernos de Saúde Pública)
la	publication language code (e.g. pt - Portuguese, es - Spanish)
type	document type
pid	publication identifier
publication_year	publication year of publication
sponsor	sponsor
aff_country	country code of the author's affiliation
aff_institution	author affiliation institution
volume	article volume
issue	article issue
elocation	elocation
doi	DOI number
issn	journal ISSN
in	SciELO colection code (e.g. scl - Brasil, col - Colômbia)
use_license	article usage license code

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