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Abstract Introduction. The multifactorial etiology of gastroenteritis emphasizes the need for different laboratory methods to identify or exclude infectious agents and evaluate the severity of diarrheal disease. Objective. To diagnose the infectious etiology in diarrheic children and to evaluate some fecal markers associated with intestinal integrity. Materials and methods. The study group comprised 45 children with diarrheal disease, tested for enteropathogens and malabsorption markers, and 76 children whose feces were used for fat evaluation by the traditional and acid steatocrit tests. Results. We observed acute diarrhea in 80% of the children and persistent diarrhea in 20%. Of the diarrheic individuals analyzed, 40% were positive for enteropathogens, with rotavirus (13.3%) and Giardia duodenalis (11.1%) the most frequently diagnosed. Among the infected patients, occult blood was more evident in those carrying pathogenic bacteria (40%) and enteroviruses (40%), while steatorrhea was observed in infections by the protozoa G. duodenalis (35.7%). Children with diarrhea excreted significantly more lipids in feces than non-diarrheic children, as determined by the traditional (p<0.0003) and acid steatocrit (p<0.0001) methods. Moreover, the acid steatocrit method detected 16.7% more fecal fat than the traditional method. Conclusions. Childhood diarrhea can lead to increasingly severe nutrient deficiencies. Steatorrhea is the hallmark of malabsorption, and a stool test, such as the acid steatocrit, can be routinely used as a laboratory tool for the semi-quantitative evaluation of fat malabsorption in diarrheic children.

Resumen Introducción. La etiología multifactorial de la gastroenteritis enfatiza la necesidad de usar diferentes métodos de laboratorio para identificar o excluir agentes infecciosos y evaluar la gravedad de la enfermedad diarreica. Objetivo. Diagnosticar la etiología infecciosa de la diarrea en niños y evaluar algunos marcadores fecales asociados con la integridad intestinal. Materiales y métodos. Se estudiaron 45 niños con enfermedad diarreica, en los cuales se evaluaron la presencia de enteropatógenos y los marcadores de malabsorción. Se analizaron las muestras fecales de 76 niños, mediante las pruebas de esteatocrito tradicional y esteatocrito ácido, para la cuantificación de la grasa. Resultados. Se observó diarrea aguda en el 80 % de los niños y diarrea persistente en el 20 %. De los individuos con diarrea, el 40 % fue positivo para enteropatógenos; los más diagnosticados fueron rotavirus (13,3 %) y Giardia duodenalis (11,1 %). Entre los pacientes infectados, la sangre oculta fue más evidente en aquellos portadores de bacterias patógenas (40 %) o enterovirus (40%), mientras que la esteatorrea se observó en infecciones por el protozoo G. duodenalis (35,7 %). Los niños con diarrea excretaron significativamente más lípidos en las heces que aquellos sin diarrea, según lo determinado por los métodos de esteatocrito tradicional (p<0,0003) y esteatocrito ácido (p<0,0001). Conclusiones. La diarrea infantil puede provocar deficiencias graves de nutrientes. La esteatorrea es distintiva de la malabsorción intestinal y puede detectarse mediante la estimación del esteatocrito ácido. Esta prueba podría utilizarse de forma rutinaria como una herramienta de laboratorio para la evaluación semicuantitativa de la malabsorción de grasas en niños con diarrea.

https://doi.org/10.7705/biomedica.6913

Five-year performance analysis of a cystic fibrosis newborn screening program in northeastern Brazil Fiveyear Five year
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Godoy, Carolina

; Paixão, Danielle C.

; Boa-Sorte, Ney C.A.

; Amorim, Tatiana

; da Silva Filho, Luiz Vicente R.F.

; Souza Filho, Edna Lúcia

Jornal de Pediatria

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jan 2023, Volume 99 N. 1 Pages 23 - 30

Abstract: En | Text: En | PDF: En

Abstract Objective: To analyze the performance of the cystic fibrosis (CF) newborn screening (NBS) program over its first five years in a Brazilian northeastern state. Methods: A population-based study using a screening algorithm based on immunoreactive trypsinogen (IRT)/IRT. Data were retrieved from the state referral screening center registry. The program performance was evaluated using descriptive indicators such as the results of an active search, coverage, newborn’s age at the time of blood sampling, the time between sample collection and its arrival at the laboratory, and the child’s age at diagnosis of disease. Results: The public CF screening program covered 82.6% of the 1,017,576 births that occurred, with an accumulated five-year incidence of 1:20,767 live births. The median (25th-75th) age at diagnosis was 3.5 (2.3–7.3) months. The sampling before 7 days of life for the first IRT (IRT1) increased between 2013 and 2017 from 42.2 to 48.3%. Around 5% of IRT1 samples and 30% of the second samples were collected after 30 days of life. In the first and second stages of screening, 23.6% and 19.9% of the infants, respectively, were lost to follow-up. In both stages of screening, the samples were retained at the health units for a median (25th–75th) of 9.0 (7.0–13.0) days. Conclusions: The coverage by the CF-NBS program was satisfactory as compared to other Brazilian state rates and the percentage of IRT1 samples collected within the first week of life increased progressively. However, time of samples retention at the health units, inappropriate sampling, inherent methodological problems, and loss of follow-up need to improve. Objective (CF NBS (NBS Methods populationbased population IRT/IRT. IRTIRT /IRT. (IRT)/IRT registry search newborns s laboratory childs child disease Results 826 82 6 82.6 1017576 1 017 576 1,017,57 occurred fiveyear year 120,767 120767 20,767 20 767 1:20,76 25th75th thth 25th 75th th (25th-75th 35 3 5 3. 2.3–7.3 2373 2 (2.3–7.3 months (IRT1 201 422 42 42. 483 48 48.3% 236 23 23.6 199 19 9 19.9 infants respectively followup. followup follow up. up 25th–75th (25th–75th 90 0 9. 7.0–13.0 70130 13 (7.0–13.0 Conclusions CFNBS progressively However problems improve IRT/IRT /IRT 8 82. 101757 01 57 1,017,5 120 120,76 12076 20767 20,76 76 1:20,7 2.3–7. 237 (2.3–7. (IRT 4 48.3 23. 19. 7.0–13. 7013 (7.0–13. 10175 1,017, 12 120,7 1207 2076 20,7 1:20, 2.3–7 (2.3–7 48. 7.0–13 701 (7.0–13 1017 1,017 120, 207 20, 1:20 2.3– (2.3– 7.0–1 70 (7.0–1 101 1,01 1:2 2.3 (2.3 7.0– (7.0– 10 1,0 1: 2. (2. 7.0 (7.0 1, (2 7. (7. ( (7

https://doi.org/10.1016/j.jped.2022.04.002

Brazilian guidelines for the pharmacological treatment of the pulmonary symptoms of cystic fibrosis. Official document of the Sociedade Brasileira de Pneumologia e Tisiologia (SBPT, Brazilian Thoracic Association) fibrosis SBPT, SBPT (SBPT Association
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Athanazio, Rodrigo Abensur

; Tanni, Suzana Erico

; Ferreira, Juliana

; Dalcin, Paulo de Tarso Roth

; Fuccio, Marcelo B de

; Esposito, Concetta

; Canan, Mariane Gonçalves Martynychen

; Coelho, Liana Sousa

; Firmida, Mônica de Cássia

; Almeida, Marina Buarque de

; Marostica, Paulo José Cauduro

; Monte, Luciana de Freitas Velloso

; Souza, Edna Lúcia

; Pinto, Leonardo Araujo

; Rached, Samia Zahi

; Oliveira, Verônica Stasiak Bednarczuk de

; Riedi, Carlos Antonio

; Silva Filho, Luiz Vicente Ribeiro Ferreira da

Jornal Brasileiro de Pneumologia

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2023, Volume 49 N. 2 elocation e20230040

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A fibrose cística (FC) é uma doença genética que resulta em disfunção da proteína reguladora de condutância transmembrana da FC (CFTR), que é um canal de cloro e bicarbonato expresso na porção apical de células epiteliais de diversos órgãos. A disfunção dessa proteína resulta em manifestações clínicas diversas, envolvendo primariamente os sistemas respiratório e gastrointestinal com redução da qualidade e expectativa de vida. A FC ainda é uma patologia incurável, porém o horizonte terapêutico e prognóstico é hoje totalmente distinto e muito mais favorável. O objetivo destas diretrizes foi definir recomendações brasileiras baseadas em evidências em relação ao emprego de agentes farmacológicos no tratamento pulmonar da FC. As perguntas PICO (acrônimo baseado em perguntas referentes aos Pacientes de interesse, Intervenção a ser estudada, Comparação da intervenção e Outcome [desfecho] de interesse) abordaram aspectos relativos ao uso de moduladores de CFTR (ivacaftor, lumacaftor + ivacaftor e tezacaftor + ivacaftor), uso de dornase alfa, terapia de erradicação e supressão crônica de Pseudomonas aeruginosa, e erradicação de Staphylococcus aureus resistente a meticilina e do complexo Burkholderia cepacia. Para a formulação das perguntas, um grupo de especialistas brasileiros foi reunido e realizou-se uma revisão sistemática sobre os temas, com meta-análise quando aplicável. Os resultados encontrados foram analisados quanto à força das evidências compiladas, sendo concebidas recomendações seguindo a metodologia GRADE. Os autores acreditam que o presente documento represente um importante avanço a ser incorporado na abordagem de pacientes com FC, objetivando principalmente favorecer seu manejo, podendo se tornar uma ferramenta auxiliar na definição de políticas públicas relacionadas à FC. (FC CFTR, , (CFTR) órgãos diversas vida incurável favorável acrônimo interesse estudada desfecho [desfecho ivacaftor, (ivacaftor ivacaftor) alfa aeruginosa cepacia realizouse realizou temas metaanálise meta análise aplicável compiladas GRADE manejo (CFTR

ABSTRACT Cystic fibrosis (CF) is a genetic disease that results in dysfunction of the CF transmembrane conductance regulator (CFTR) protein, which is a chloride and bicarbonate channel expressed in the apical portion of epithelial cells of various organs. Dysfunction of that protein results in diverse clinical manifestations, primarily involving the respiratory and gastrointestinal systems, impairing quality of life and reducing life expectancy. Although CF is still an incurable pathology, the therapeutic and prognostic perspectives are now totally different and much more favorable. The purpose of these guidelines is to define evidence-based recommendations regarding the use of pharmacological agents in the treatment of the pulmonary symptoms of CF in Brazil. Questions in the Patients of interest, Intervention to be studied, Comparison of interventions, and Outcome of interest (PICO) format were employed to address aspects related to the use of modulators of this protein (ivacaftor, lumacaftor+ivacaftor, and tezacaftor+ivacaftor), use of dornase alfa, eradication therapy and chronic suppression of Pseudomonas aeruginosa, and eradication of methicillin-resistant Staphylococcus aureus and Burkholderia cepacia complex. To formulate the PICO questions, a group of Brazilian specialists was assembled and a systematic review was carried out on the themes, with meta-analysis when applicable. The results obtained were analyzed in terms of the strength of the evidence compiled, the recommendations being devised by employing the GRADE approach. We believe that these guidelines represent a major advance to be incorporated into the approach to patients with CF, mainly aiming to favor the management of the disease, and could become an auxiliary tool in the definition of public policies related to CF. (CF CFTR (CFTR organs manifestations systems expectancy pathology favorable evidencebased based Brazil studied interventions (PICO ivacaftor, ivacaftor (ivacaftor lumacaftorivacaftor lumacaftor lumacaftor+ivacaftor tezacaftor+ivacaftor, tezacaftorivacaftor tezacaftor+ivacaftor , tezacaftor tezacaftor+ivacaftor) alfa aeruginosa methicillinresistant methicillin resistant complex questions themes metaanalysis meta analysis applicable compiled

https://doi.org/10.36416/1806-3756/e20230040

Consumo de suplementos dietarios en niños escolares de Bucaramanga, Colombia. Un estudio piloto
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Herrera-Anaya, Elizabeth

; Gamboa-Delgado, Edna Magaly

; Silva-Mora, Martha Lucía

Revista de la Universidad Industrial de Santander. Salud

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dec 2022, Volume 54 elocation e319

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Introducción: La obesidad infantil es un problema global de salud pública. Una de las causas subyacentes de este evento complejo y multicausal se relaciona con la alta ingesta de energía. El uso inadecuado de suplementos dietarios podría superar los requerimientos de energía y nutrientes y generar una ganancia excesiva de peso corporal en los niños. Objetivo: Describir el tipo, cantidad y frecuencia de consumo de suplementos dietarios ingeridos por niños y niñas durante la edad preescolar, y evaluar la correlación entre este consumo y la composición corporal de los mismos en la edad escolar. Metodología: Estudio de corte transversal analítico. Estudio piloto realizado en niños en edad escolar de Bucaramanga, Colombia. Variables dependientes: porcentaje de grasa corporal y masa músculo esquelética. Principal variable independiente: consumo de suplementos dietarios. La correlación entre variables fue evaluada usando el coeficiente de correlación de Spearman (rho). Resultados: La prevalencia del consumo de suplementos dietarios en algún momento, antes de los cinco años, fue de 51,11% (IC 95%, 0,35 a 0,66). Las formas de presentación usadas con mayor frecuencia fueron en polvo, granulado y líquido. Los tipos de suplementos utilizados correspondieron a fórmulas poliméricas (40,91%), seguidos por aceite de hígado de bacalao (36,36%). A mayor consumo de suplementos dietarios, se observó mayor porcentaje de grasa corporal (rho = 0,346) y menores valores de masa muscular esquelética (rho = -0,286). Sin embargo, estas correlaciones no fueron estadísticamente significativas (p = 0,114 y p = 0,286, respectivamente). Conclusión: Este estudio encontró una correlación débil y positiva entre el consumo de suplementos dietarios en la primera infancia y el porcentaje de grasa corporal y una correlación débil y negativa con la masa músculo esquelética; sin embargo, no hubo significancia estadística. Es necesario continuar investigando acerca de potenciales efectos no deseados del consumo inadecuado de suplementos durante la primera infancia.

Abstract Introduction: Childhood obesity is a global public health problem. One of the underlying causes of this complex and multicausal event is related to high energy intake. Inappropriate use of dietary supplements could exceed energy and nutrient requirements resulting in excessive body weight gain in children. Objective: To describe the type, quantity and frequency of consumption of dietary supplements ingested by boys and girls during preschool age and to evaluate the correlation between this consumption and their body composition at school age. Methods: Analytical cross-sectional study. Pilot study, carried out in school children from Bucaramanga, Colombia. Dependent variables: body fat percentage and skeletal muscle mass. Main independent variable: consumption of dietary supplements. The correlation between variables was evaluated using Spearman's correlation coefficient (rho). Results: The prevalence of consumption of dietary supplements at some point before the age of five was 51.11% (95% CI, 0.35 to 0.66). The most frequently used forms of presentation were powder, granules and liquid. The types of supplements used corresponded to polymeric formulas (40.91%), followed by cod liver oil (36.36%). A higher consumption of dietary supplements showed a higher percentage of body fat (rho=0.346) and lower values of skeletal muscle mass (rho= -0.286). However, these correlations were not statistically significant (p=0.114 and p=0.286, respectively). Conclusion: This study found a weak positive correlation between dietary supplement use in early childhood and body fat percentage and a weak negative correlation with skeletal muscle mass; however, there was no statistical significance. Further research is needed on the potential undesirable effects of inappropriate supplement use in early childhood.

https://doi.org/10.18273/saluduis.54.e:22035 18 downloads

Reference values for spirometry in Brazilian children
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Jones, Marcus Herbert

; Vidal, Paula Cristina Vasconcellos

; Lanza, Fernanda Cordoba

; Silva, Danielle Corrêa França de Melo Franco

; Pitrez, Paulo Márcio

; Olmedo, Ana Paula Bigliardi de Freitas

; Burity, Edjane Figueiredo

; Schisler, Kennedy Long

; Pinto, Leonardo Araújo

; Winck, Aline Dill

; Souza, Edna Lúcia Santos de

; Oliveira, Anick Augustin

; Ribeiro, Maria Ângela Gonçalves de Oliveira

; Torres, Lidia Alice Gomes Monteiro Marin

; March, Maria de Fátima Bazhuni Pombo

Jornal Brasileiro de Pneumologia

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2020, Volume 46 N. 3 elocation e20190138

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Gerar valores de referência para espirometria em crianças brasileiras de 3-12 anos de idade e comparar os resultados obtidos com as equações em uso no Brasil. Métodos: Foram incluídas crianças sadias de 3-12 anos recrutadas em 14 centros (dados primários) e resultados de espirometria de crianças com as mesmas características de seis bancos de dados (dados secundários). As equações quantílicas foram geradas após transformações logarítmicas dos dados espirométricos e antropométricos. A classificação por cor da pele foi autodeclarada. Os resultados obtidos foram comparados com os previstos nas equações em uso no Brasil para testar sua adequação. Resultados: Foram incluídos 1.990 indivíduos de 21 fontes de dados primários e secundários, sendo 1.059 (53%) do sexo feminino. Equações para VEF1, CVF, VEF1/CVF, FEF25-75% e FEF25-75%/CVF foram geradas para crianças brancas e para crianças negras e pardas. Os logaritmos da estatura e da idade e a cor da pele foram os melhores preditores para VEF1 e CVF. Os resultados obtidos foram significativamente maiores do que as estimativas geradas pelas equações em uso no Brasil, tanto para valores previstos quanto para o limite inferior da normalidade, particularmente em crianças negras e pardas. Conclusões: Novas equações espirométricas foram geradas para crianças brasileiras de 3-12 anos de cor branca, negra e parda. As equações atualmente em uso no Brasil parecem subestimar a função pulmonar de crianças brasileiras menores de 12 anos de idade e deveriam ser substituídas pelas equações propostas neste estudo.

ABSTRACT Objective: To generate reference values for spirometry in Brazilian children 3-12 years of age and to compare those values with the values employed in the equations currently in use in Brazil. Methods: This study involved healthy children, 3-12 years of age, recruited from 14 centers (primary data) and spirometry results from children with the same characteristics in six databases (secondary data). Reference equations by quantile regressions were generated after log transformation of the spirometric and anthropometric data. Skin color was classified as self-reported by the participants. To determine the suitability of the results obtained, they were compared with those predicted by the equations currently in use in Brazil. Results: We included 1,990 individuals from a total of 21 primary and secondary data sources. Of those, 1,059 (53%) were female. Equations for FEV1, FVC, the FEV1/FVC ratio, FEF between 25% and 75% of the FVC (FEF25-75%) and the FEF25-75%/FVC ratio were generated for white-, black-, and brown-skinned children. The logarithms for height and age, together with skin color, were the best predictors of FEV1 and FVC. The reference values obtained were significantly higher than those employed in the equations currently in use in Brazil, for predicted values, as well as for the lower limit of normality, particularly in children with self-reported black or brown skin. Conclusions: New spirometric equations were generated for Brazilian children 3-12 years of age, in the three skin-color categories defined. The equations currently in use in Brazil seem to underestimate the lung function of Brazilian children 3-12 years of age and should be replaced by the equations proposed in this study.

https://doi.org/10.36416/1806-3756/e20190138 957 downloads

Relación entre el exceso de peso y la manipulación de alimentos en servicios de alimentación. Bucaramanga, Colombia
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Cáceres-Jerez, Martha Lucía

; Gamboa-Delgado, Edna Magaly

; Silva-Mora, Martha Lucía

Revista de la Facultad de Medicina

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mar 2019, Volume 67 N. 1 Pages 45 - 50

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Introducción. La facilidad para consumo de alimentos de los trabajadores de servicios de alimentación puede alterar su estado nutricional. Objetivo. Evaluar la asociación entre ser manipulador de alimentos y presentar sobrepeso/obesidad en trabajadores de servicios de alimentación. Materiales y métodos. Estudio de corte transversal analítico con personal de servicios de alimentación de Bucaramanga, Colombia (n=109). Se seleccionó un grupo de trabajadores que manipulaban alimentos (grupo expuesto) y otro que no (grupo no expuesto). Se realizaron modelos de regresión binomial para estimar la asociación entre las variables de interés. Todos los participantes firmaron consentimiento informado. Resultados. La prevalencia de sobrepeso u obesidad fue de 69.44% (IC95%: 59.84-77.94). Hubo una mayor prevalencia de sobrepeso y obesidad en los manipuladores de alimentos que en los demás trabajadores (35% vs. 10% y 23% vs. 7%, respectivamente; p=0.030). Después del ajuste por sexo, edad y nivel de actividad física, las variables asociadas a sobrepeso u obesidad en los trabajadores fueron ser manipulador de alimentos y pertenecer al nivel socioeconómico bajo/medio. Conclusiones. Los manipuladores de alimentos tienen mayor probabilidad de presentar exceso de peso.

Abstract Introduction: Food service workers have greater availability of food for consumption, which may alter their nutritional status. Objective: To assess the association between being a food handler and the presence of excess weight or obesity in food service workers. Materials and methods: Analytical cross-sectional study with food service workers from Bucaramanga, Colombia (n=109). A group of food handlers (exposed group) and another group that did not handle food (unexposed group) were selected. Binomial regression models were used to estimate the association between variables of interest. All participants signed informed consent. Results: The prevalence of excess weight or obesity was 69.44% (CI95%: 59.84-77.94). Food handlers had a higher prevalence of excess weight and obesity than other workers surveyed (35% vs. 10% and 23% vs. 7%, respectively; p=0.030). After adjustment for sex, age and level of physical activity, the variables associated with overweight or obesity in workers were food handler and low/ medium socioeconomic status. Conclusions: Food handlers are more likely to be overweight.

https://doi.org/10.15446/revfacmed.v67n1.65818 1878 downloads

REFLEXÕES SOBRE O SABER, SABER-FAZER E SABER-ESTAR NA FORMAÇÃO DE ENFERMEIROS
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Farias, Maria Sinara

; Brito, Larissa Ludmila Monteiro de Souza

; Santos, Aliniana da Silva

; Guedes, Maria Vilaní Cavalcante

; Silva, Lúcia de Fátima da

; Chaves, Edna Maria Camelo

Reme: Revista Mineira de Enfermagem

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2019, Volume 23 elocation e-1207

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

ABSTRACT This is a reflective study to discuss knowledge, knowing-how and how to behave in Nursing training. In this sense, it is emphasized that knowledge for Nursing training corresponds to the knowledge required for a good professional performance, which, linked to the knowing-how, considered as the skills necessary for providing care, reflects a qualified professional, who acknowledges the competence of understanding how to behave in Nursing. Thus, this reflection leads to a better understanding of the importance of knowledge for Nursing training, as this understanding is currently neglected by some educational institutions.

RESUMEN Se trata de un estudio reflexivo con miras a discutir sobre saber, saber cómo hacer y saber cómo estar en la educación de los enfermeros. En ese sentido, cabe destacar que para la educación de los enfermeros el saber corresponde al conocimiento necesario para el buen desempeño profesional. El saber vinculado al saber hacer, que es la habilidad para cuidar, se refleja en el profesional bien calificado que reconoce la importancia de saber estar en Enfermería. Esta reflexión permite comprender mejor la importancia de los distintos tipos de conocimiento para la educación de los enfermeros ya que hoy algunas instituciones educativas descuidan esta idea.

RESUMO Trata-se de estudo reflexivo que se propõe a discutir sobre o saber, saber-fazer e saber-estar na formação dos enfermeiros. Nesse sentido, ressalta-se que o saber para a formação dos enfermeiros corresponde ao conhecimento necessário para um bom desempenho profissional que, atrelado ao saber-fazer, que são as habilidades necessárias para o cuidar, reflete um profissional qualificado, o qual reconhece a competência de saber-estar na enfermagem. Assim, essa reflexão leva a melhor compreensão sobre a importância dos saberes para a formação de enfermeiros, uma vez que, atualmente, essa compreensão é negligenciada por algumas instituições formadoras.

https://doi.org/10.5935/1415-2762.20190055 9 downloads

Hepatobiliary disease in children and adolescents with cystic fibrosis,
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Nascimento, Fernanda de S.

; Sena, Nelson A.

; Ferreira, Tatiane da A.

; Marques, Cibele D.F.

; Silva, Luciana R.

; Souza, Edna Lúcia

Jornal de Pediatria

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oct 2018, Volume 94 N. 5 Pages 504 - 510

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivos: Os objetivos do estudo foram determinar a frequência da doença hepatobiliar em pacientes com fibrose cística e descrever o perfil sociodemográfico, clínico e laboratorial destes. Métodos: Estudo retrospectivo, descritivo e analítico de 55 pacientes com diagnóstico de fibrose cística, entre três meses e 21 anos, acompanhados de janeiro de 2008 a junho de 2016 em um centro de referência. Foi realizada consulta aos prontuários médicos, registrando-se os dados sociodemográficos, clínicos e laboratoriais, incluindo-se alterações hepatobiliares, exames de imagem, estudos genéticos, biópsias hepáticas e endoscopias digestivas altas. Resultados: A doença hepatobiliar foi diagnosticada em 16,4% dos pacientes e ocorreu como manifestação inicial da fibrose cística em 55,6% destes casos. O diagnóstico da hepatopatia ocorreu antes ou concomitante ao diagnóstico da fibrose cística em 88,9% das crianças. Todos os pacientes com doença hepatobiliar foram considerados não brancos, havendo predominância do sexo feminino (77,8%) e mediana (I.I.Q) de idade de 54 (27-91) meses. Em comparação com o grupo sem doença hepatobiliar, as crianças com hepatopatia tiveram maior frequência de mutações graves no gene CFTR identificadas (77,8% vs 39,6%; p = 0,033) e de insuficiência pancreática grave (88,9% vs 31,6%; p = 0,007). Conclusão: A frequência de doença hepatobiliar foi elevada, observando-se um diagnóstico muito precoce da mesma e de suas complicações na casuística estudada. Houve associação estatística entre a ocorrência de doença hepatobiliar e a presença de insuficiência pancreática e de mutações graves do gene CFTR. Enfatiza-se que a fibrose cística represente um importante diagnóstico diferencial de hepatopatias na infância.

Abstract Objectives: The aims of the study were to determine the frequency of hepatobiliary disease in patients with cystic fibrosis and to describe the sociodemographic, clinical, and laboratory profile of these patients. Methods: This was a retrospective, descriptive, and analytical study of 55 patients diagnosed with cystic fibrosis, aged between 3 months and 21 years, followed-up from January 2008 to June 2016 in a referral center. Medical records were consulted and sociodemographic, clinical and laboratory data, including hepatobiliary alterations, imaging studies, genetic studies, liver biopsies, and upper digestive endoscopies were registered. Results: Hepatobiliary disease was diagnosed in 16.4% of the patients and occurred as an initial manifestation of cystic fibrosis in 55.6% of these cases. The diagnosis of hepatopathy occurred before or concomitantly with the diagnosis of cystic fibrosis in 88.9% of the children. All patients with hepatobiliary disease were considered non-white, with a predominance of females (77.8%) and median (IQR) of 54 (27-91) months. Compared with the group without hepatobiliary disease, children with liver disease had a higher frequency of severe mutations identified in the CFTR gene (77.8% vs. 39.6%, p = 0.033) and severe pancreatic insufficiency (88.9% vs. 31.6%, p = 0.007). Conclusion: The frequency of hepatobiliary disease was high, with a very early diagnosis of the disease and its complications in the studied series. A statistical association was observed between the occurrence of hepatobiliary disease and the presence of pancreatic insufficiency and severe mutations in the CFTR gene. It is emphasized that cystic fibrosis is an important differential diagnosis of liver diseases in childhood.

https://doi.org/10.1016/j.jped.2017.07.006 987 downloads

O desenvolvimento de coleções em bibliotecas universitárias sob o olhar da teoria da complexidade e da análise de domínio
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Vieira Pinheiro, Liliane

; Arruda Café, Lígia Maria

; da Silva, Edna Lúcia

Biblios

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oct 2018, N. 73 Pages 65 - 90

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Objective. This study proposed a reflection on collection development for university libraries inspired by the Complexity Theory and Domain Analysis. A theoretical contribution was sought in Morin's Complexity Theory and in the social paradigm of Information Science, more specifically in Hjørland's Domain Analysis, to think about how guidelines could be woven for the Collection Development in university libraries in order to face the challenges of Contemporaneity. Method. . It establishes the Complexity Theory assumptions and the qualitative perspective to approach the problem. To do so, it relies on four analysis dimensions: the epistemological, the published thinking, the institutionalized thinking and of the current thinking. Results. The results indicate that collection development includes innumerous elements and faces difficulties, it is guided by institutional and users demands, it requires the participation of the academic community, including in drafting the policy, which should be aligned to the mission of the institution and constantly updated. Conclusions. It concludes that thinking about the guidelines for Collection Development, adopting the social perspective of the domain analysis and based on Morin’s tetralogical ring, contributes to the denudation of issues surrounding that process in university libraries

Objetivo. Pesquisa que propôs pensar o Desenvolvimento de Coleções em bibliotecas universitárias inspirado na Teoria da Complexidade e na Análise de Domínio. Buscou aporte teórico na Teoria da Complexidade de Morin e no paradigma social da Ciência da Informação, mais especificamente na Análise de Domínio de Hjørland, para pensar como poderiam ser tecidas diretrizes para o Desenvolvimento de Coleções em bibliotecas universitárias de forma a enfrentar os desafios da contemporaneidade. Método. Estabelece como caminho metodológico os pressupostos da Teoria da Complexidade e a perspectiva qualitativa para a abordagem do problema. Para tal, conta com quatro dimensões de análise: epistemológica, do pensamento registrado, do pensamento institucionalizado e do pensamento vigente Resultados. Os resultados indicam que o Desenvolvimento de Coleções engloba inúmeros elementos e enfrenta dificuldades, é orientado ao atendimento das demandas da instituição e usuários, requer a participação da comunidade acadêmica, inclusive na elaboração da política, que deve ser alinhada à missão da instituição e atualizada constantemente. Conclusão. Conclui que pensar sobre as diretrizes para o Desenvolvimento de Coleções, adotando a perspectiva social da Análise de Domínio e baseado no anel tetralógico de Morin, contribui para o desnudamento de questões que envolvem esse processo em bibliotecas universitárias.

https://doi.org/10.5195/biblios.2018.490

10.

LIMA BEAN ( Phaseolus lunatus L.) SEEDS EXPOSED TO DIFFERENT SALT CONCENTRATIONS AND TEMPERATURES
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NASCIMENTO, MARIA DAS GRAÇAS RODRIGUES DO

; ALVES, EDNA URSULINO

; SILVA, MARIA LÚCIA MAURÍCIO DA

; RODRIGUES, CAROLINE MARQUES

Revista Caatinga

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sep 2017, Volume 30 N. 3 Pages 738 - 747

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A problemática da salinidade está aumentando cada vez mais nas regiões semiáridas do nordeste brasileiro, por isso estudos aprofundados com culturas cultivadas nessas regiões principalmente que sejam tolerantes a níveis de salinidades são importantes. Nesse sentido, o objetivo com este trabalho foi avaliar à tolerância de sementes de cultivares de feijão-fava (Phaseolus lunatus L.) a condição de estresse salino em diferentes temperaturas. O trabalho foi realizado no Laboratório de Análise de Sementes do Centro de Ciências Agrárias da Universidade Federal da Paraíba, em Areia, PB, com sementes de quatro cultivares de feijão-fava (Branca, Orelha de Vó, Rosinha e Roxinha), em delineamento experimental inteiramente ao acaso. Para simulação do estresse salino, utilizou-se como soluto o cloreto de sódio (NaCl), nas concentrações de 0,0 (testemunha); 1,5; 3,0; 4,5; 6,0; 7,5 e 9,0 dS m-1 submetidas a temperaturas constantes de 25, 30 e 35 °C. Na avaliação do efeito dos tratamentos, realizou-se teste de germinação e vigor (primeira contagem e índice de velocidade de germinação, comprimento e massa seca de plântulas). A germinação de sementes dos cultivares de feijão-fava (Phaseolus lunatus L.) é elevada quando submetidas a concentrações salinas de até 9 dS m-1, sendo as sementes do cultivar Roxinha as mais tolerantes à salinidade simulada com cloreto de sódio. A temperatura de 35 °C não favorece o desenvolvimento das plântulas em condições salinas para todos os cultivares avaliados.

ABSTRACT Salinity problems are increasing in the semi-arid regions of northeastern Brazil. Thus, detailed studies of the region’s cultured crops, primarily salt-tolerant species, are important. Therefore, the aim of the present study was to evaluate the salt stress tolerance of lima bean (Phaseolus lunatus L.) seeds at different temperatures. This study was conducted in the Seed Analysis Laboratory, Agricultural Sciences Center, Federal University of Paraíba (Areia, PB, Brazil) by using seeds of four lima bean cultivars (Branca, Orelha de Vó, Rosinha, and Roxinha) in a randomized experimental design. Sodium chloride (NaCl) was used as a solute for salt-stress simulation at the following concentrations: 0.0 (control), 1.5, 3.0, 4.5, 6.0, 7.5, and 9.0 dS m-1; temperatures were maintained constant at 25°C, 30°C, and 35°C. Germination and vigor tests were performed to evaluate the treatment effects (first count, germination rate index, seedling length, and dry matter). Germination rate of lima bean seeds increased in salt concentrations up to 9 dS m-1, and seeds of Roxinha cultivar exhibited the highest salinity tolerance. The development of lima bean cultivar seedlings was negatively affected at 35°C under high-salinity conditions.

https://doi.org/10.1590/1983-21252017v30n322rc 3043 downloads

11.

Schinus terebinthifolius: phenolic constituents and in vitro antioxidant, antiproliferative and in vivo anti-inflammatory activities
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Silva, Marciane M. da

; Iriguchi, Edna K.K.

; Kassuya, Candida Aparecida L.

; Vieira, Maria do Carmo

; Foglio, Mary Ann

; Carvalho, João Ernesto de

; Ruiz, Ana Lúcia T.G.

; Souza, Kely de P.

; Formagio, Anelise S.N.

Revista Brasileira de Farmacognosia

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aug 2017, Volume 27 N. 4 Pages 445 - 452

Abstract: En | Text: En | PDF: En

ABSTRACT Schinus terebinthifolius Raddi, Anacardiaceae, native to Brazil, is referred to as "pimento-rosa" and is used to treat inflammatory disease in folk medicine. Studies have reported important pharmacological properties, but these effects have still not been fully exploited. This study reports that the crude extract and isolated compounds of S. terebinthifolius (leaves) have in vitro antioxidant, antiproliferative, and in vivo anti-inflammatory activities. The samples were evaluated for antioxidant activity using 2, 2-diphenyl-1-picrylhydrazyl, β-carotene/linoleic acid and 2,2′-azino-bis-(3-ethylbenzothiazoline)-6-sulphonic acid reagents. The anti-inflammatory effects were assayed against a carrageenan-induced paw oedema model in mice to test doses of 10, 100 and 300 mg/kg at different time points in addition to myeloperoxidase activity analysis. The antiproliferative activity was evaluated using ten human tumour cell lines. Two derivatives of gallic acid and four flavonoids were isolated and exhibited considerable antioxidant activity. The extract and its compounds showed selectivity towards ovarian cancer cells, with growth inhibitory activity values ranging from 1.9 to 6.5 µg/ml. Sample extracts and methyl gallate significantly inhibited carrageenan-induced oedema in the mice paw oedema experimental model. The calculated topological polar surface area for methyl gallate (86.98 Å2) showed good intestinal absorption. The effects reported herein are be related to the presence of flavonoids and the galloyl phenolic derivative content.

https://doi.org/10.1016/j.bjp.2016.12.007 1256 downloads

12.

As instituições, produtores e produtos científicos do campo da moda no Brasil
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Trevisol Neto, Orestes

; Café, Ligia Maria Arruda

; Silva, Edna Lúcia da

Perspectivas em Ciência da Informação

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jun 2017, Volume 22 N. 2 Pages 152 - 169

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O interesse desta pesquisa está voltado para a análise da institucionalização científica no campo da Moda concentrando-se nos agentes, locais e processos de produção e comunicação científica. Os pressupostos que mobilizam o desenvolvimento desta pesquisa estão alicerçados na crença que os agentes, as instituições produtoras e a própria produção científica são responsáveis pela consistência científica do campo e pelo seu nível de institucionalização. A pesquisa teve como objetivo geral analisar a institucionalização científica do campo da Moda no Brasil. Possui caráter descritivo e exploratório, faz uma abordagem qualiquantitativa (mista) e utiliza técnica de pesquisa documental. O corpus da pesquisa foi constituído pelos dados retirados dos grupos de pesquisa em moda cadastrados no Diretório de Grupos de Pesquisa, dos Currículos Lattes dos pesquisadores, dos sites dos programas de pós-graduação, eventos e revistas científicas e demais documentos usados como fontes para coleta de dados. A cobertura temporal compreendeu os anos de 1988 a 2013. Na vertente da institucionalização social foram analisados os cursos de graduação e pós-graduação, as revistas, a associação de pesquisa, os eventos e os grupos de pesquisa desse campo. A importância da Associação Brasileira de Estudos e Pesquisa em Moda (ABEPEM) no processo de institucionalização social do campo ficou destacada. Na vertente da institucionalização cognitiva foram analisados os pesquisadores e a produção científica do campo. Nesse aspecto, foi possível detectar a existência de uma comunidade científica pequena e foi percebida a importância dada pelos integrantes dessa comunidade para a publicação de trabalhos em eventos, o que permite estabelecer uma relação direta entre institucionalização social e cognitiva nesse campo e a importância da comunicação científica no processo de institucionalização. Os resultados apontam indícios de institucionalização embrionária cognitiva e social do campo da moda no Brasil.

ABSTRACT The interest of this research is the scientific institutionalization of the fashion field focused on agents, places, production processes and scientific communication. The assumptions that move the development of this research are based in the belief that the agents, the producer institutions, and the scientific production are responsible for the scientific consistency of the field and for its institutionalization level. The general objective of this research is to analyze the scientific institutionalization of the Fashion field in Brazil. The research is descriptive and exploratory, using a qualitative and quantitative approach and a documentary research approach. The data is gathered in the research groups registered in the Brazilian Research Groups Directory, in the researchers résumé, from the graduate programs websites, from events, journals and other documents. The period analyzed was from 1988 to 2013. In terms of social institutionalization were analyzed the graduate and postgraduate educational courses, journals, research associations, events and research groups of the field. The importance of the Brazilian Association of Studies and Research in Fashion (ABEPEM) in the process of social institutionalization of Fashion field is highlighted. In terms of cognitive institutionalization the researchers and the scientific production of this field were analyzed. It was possible to detect that there is a small scientific community that believes that is important to published papers in events, which reveals a close relationship between the social and the cognitive institutionalizations of the field and the importance of scientific communication in the institutionalization process. The result shows evidence of embryonic cognitive and social institutionalization of the fashion field in Brazil.

https://doi.org/10.1590/1981-5344/2544 1318 downloads

13.

Brazilian guidelines for the diagnosis and treatment of cystic fibrosis
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Athanazio, Rodrigo Abensur

; Silva Filho, Luiz Vicente Ribeiro Ferreira da

; Vergara, Alberto Andrade

; Ribeiro, Antônio Fernando

; Riedi, Carlos Antônio

; Procianoy, Elenara da Fonseca Andrade

; Adde, Fabíola Villac

; Reis, Francisco José Caldeira

; Ribeiro, José Dirceu

; Torres, Lídia Alice

; Fuccio, Marcelo Bicalho de

; Epifanio, Matias

; Firmida, Mônica de Cássia

; Damaceno, Neiva

; Ludwig-Neto, Norberto

; Maróstica, Paulo José Cauduro

; Rached, Samia Zahi

; Melo, Suzana Fonseca de Oliveira

; Pinto, Leonardo Araújo

; Monte, Luciana Freitas Velloso

; Higa, Laurinda Yoko Shinzato

; Folescu, Tania Wrobel

; Marson, Fernando Augusto de Lima

; Sad, Isabela

; Servidoni, Maria de Fátima Correa Pimenta

; Kussek, Paulo

; Raskin, Salmo

; Zuana, Adriana Della

; Augustin, Albin

; Hoffmann, Anneliese

; Barbisan, Beatriz

; Hochhegger, Bruno

; Levy, Carlos Emilio

; Veiga, Claudine Sarmento da

; Ricachinevsky, Claudio

; Esposito, Concetta

; Escuissato, Dante

; Brandemburgo, Diego

; Marques, Elisabeth

; Aquino, Evanirso de

; Fischer, Gilberto Bueno

; Rodrigues, Joaquim Carlos

; Machado, Leticia

; Muramato, Lucia

; Costa, Lusmaia Damasceno Camargo

; Donadio, Marcio

; Castro, Marcos César Santos de

; Ribeiro, Maria Angela

; Santana, Maria Angélica

; Canan, Mariane

; Almeida, Marina Buarque de

; Britto, Murilo

; Dalcin, Paulo Roth Tarso

; Ramos, Regina Terse Trindade

; Chiba, Sonia

; Martins, Valéria de Carvalho

; Lacerda, Claudine

; Barbosa, Eliana

; Guimarães, Elizabet Vilar

; Hessel, Gabriel

; Gurmini, Jocemara

; Neri, Lenycia

; Nogueira, Marcelo Coelho

; Wayhs, Mônica Chang

; Simon, Miriam Isabel Santos

; Fernandes, Arlene Gonçalves dos Santos

; Silva, Claudia de Castro de

; Albuquerque, Cristiano Túlio Maciel

; Souza, Edna Lúcia

; Silva, Fernando Antonio de Abreu e

; Dalcin, Paulo de Tarso

; Noronha, Renata Maria de

; Teixeira, Ricardo

; Machado, Sandra Helena

; Camargo, Spencer Marcantonio

; Rozov, Tatiana

; Rodrigues, Ticiana da Costa

Jornal Brasileiro de Pneumologia

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jun 2017, Volume 43 N. 3 Pages 219 - 245

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A fibrose cística (FC) é uma doença genética autossômica recessiva caracterizada pela disfunção do gene CFTR. Trata-se de uma doença multissistêmica que ocorre mais frequentemente em populações descendentes de caucasianos. Nas últimas décadas, diversos avanços no diagnóstico e tratamento da FC mudaram drasticamente o cenário dessa doença, com aumento expressivo da sobrevida e qualidade de vida. Atualmente, o Brasil dispõe de um programa de ampla cobertura para a triagem neonatal de FC e centros de referência distribuídos na maior parte desses estados para seguimento dos indivíduos. Antigamente confinada à faixa etária pediátrica, tem-se observado um aumento de pacientes adultos com FC tanto pelo maior número de diagnósticos de formas atípicas, de expressão fenotípica mais leve, assim como pelo aumento da expectativa de vida com os novos tratamentos. Entretanto, ainda se observa uma grande heterogeneidade no acesso aos métodos diagnósticos e terapêuticos para FC entre as diferentes regiões brasileiras. O objetivo dessas diretrizes foi reunir as principais evidências científicas que norteiam o manejo desses pacientes. Um grupo de 18 especialistas em FC elaborou 82 perguntas clínicas relevantes que foram divididas em cinco categorias: características de um centro de referência; diagnóstico; tratamento da doença respiratória; tratamento gastrointestinal e nutricional; e outros aspectos. Diversos profissionais brasileiros atuantes na área da FC foram convidados a responder as perguntas formuladas pelos coordenadores. A literatura disponível foi pesquisada na base de dados PubMed com palavras-chave, buscando-se as melhores respostas às perguntas dos autores.

ABSTRACT Cystic fibrosis (CF) is an autosomal recessive genetic disorder characterized by dysfunction of the CFTR gene. It is a multisystem disease that most often affects White individuals. In recent decades, various advances in the diagnosis and treatment of CF have drastically changed the scenario, resulting in a significant increase in survival and quality of life. In Brazil, the current neonatal screening program for CF has broad coverage, and most of the Brazilian states have referral centers for the follow-up of individuals with the disease. Previously, CF was limited to the pediatric age group. However, an increase in the number of adult CF patients has been observed, because of the greater number of individuals being diagnosed with atypical forms (with milder phenotypic expression) and because of the increase in life expectancy provided by the new treatments. However, there is still great heterogeneity among the different regions of Brazil in terms of the access of CF patients to diagnostic and therapeutic methods. The objective of these guidelines was to aggregate the main scientific evidence to guide the management of these patients. A group of 18 CF specialists devised 82 relevant clinical questions, divided into five categories: characteristics of a referral center; diagnosis; treatment of respiratory disease; gastrointestinal and nutritional treatment; and other aspects. Various professionals working in the area of CF in Brazil were invited to answer the questions devised by the coordinators. We used the PubMed database to search the available literature based on keywords, in order to find the best answers to these questions.

https://doi.org/10.1590/s1806-37562017000000065 75529 downloads

14.

Fluxos de informação em projetos de inovação: estudo em três organizações
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Araújo, Wánderson Cássio Oliveira

; Silva, Edna Lúcia da

; Varvakis, Gregório

Perspectivas em Ciência da Informação

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mar 2017, Volume 22 N. 1 Pages 57 - 79

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Os fluxos de informação são responsáveis pela busca, seleção, tratamento, armazenamento, disseminação e uso das informações necessárias aos processos organizacionais que resultam em conhecimento com valor agregado às necessidades dos projetos de inovação. Analisou-se o fluxo de informação em projetos de inovação em nível tático e estratégico. Utilizou-se a pesquisa exploratória-descritiva de abordagem qualitativa com procedimentos técnicos caracterizados por estudo de múltiplos casos. O locus da pesquisa foi composto por uma organização com fins lucrativos, uma fundação sem fins lucrativos e um projeto de pesquisa de uma IES. A coleta de dados foi executada em duas etapas utilizando os seguintes instrumentos de pesquisa: (i) entrevista com o nível estratégico; (ii) questionário com o nível tático do projeto. Oito variáveis de pesquisa foram utilizadas, para a análise, divididas nas dimensões (i) elementos: atores, canais, fontes de informação e tecnologia; e (ii) aspectos: necessidades, determinantes de escolha e uso, barreiras e velocidade. Confirmou-se que fluxo de informação é processo crucial para a criação de conhecimento nos projetos estudados. Esse processo é dinâmico e influenciado pelas peculiaridades dos projetos. A administração adequada do fluxo de informação é desejável para efetivo sucesso do projeto e maximização de resultados do ponto de vista informacional.

ABSTRACT Information flows are responsible for search, selection, treatment, storage, dissemination and use of information necessary to organizational processes that result in value-added knowledge to the needs of innovation projects. Analyzed the flow of information on innovation projects in tactical and strategic level. We used the exploratory and descriptive research of qualitative approach with technical procedures characterized by multiple case study. The locus of the research was composed of a for-profit organization, a foundation nonprofit and a research project of IHE. Data collection was performed in two stages using the following research instruments: (i) interview with the strategic level; (ii) questionnaire to the tactical level of the project. Eight research variables were used for the analysis, divided into the dimensions (i) elements: actors, channels, information and technology resources; and (ii) aspects: requirements, determining selection and use, and speed barriers. It was confirmed that the information flow is crucial process for establishing knowledge in the study designs. This process is dynamic and influenced by the peculiarities of the projects. Proper management of information flow is desirable for effective project success and maximize results of the informational point of view.

https://doi.org/10.1590/1981-5344/2601 8613 downloads

15.

Incidence and treatment of methicillin-resistant S. aureus infection in cystic fibrosis patients: a cohort study
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Bittencourt, Paloma Horejs

; Pimentel, Carlos Sidney Silva

; Bonfim, Bianca Sampaio

; Marostica, Paulo José

; Souza, Edna Lúcia

Brazilian Journal of Infectious Diseases

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feb 2017, Volume 21 N. 1 Pages 107 - 111

Abstract: En | Text: En | PDF: En

Abstract In Brazil the knowledge about methicillin-resistant Staphylococcus aureus infection in cystic fibrosis patients is scarce. This study aimed to determine the incidence of respiratory tract colonization and the identification rates after a standardized treatment. A retrospective cohort was performed highlighting the history of respiratory colonizations between January 2008 and June 2015. Patients under the age of 21 years with cystic fibrosis confirmed by sweat test or genetic study receiving care at the outpatient clinics of a Teaching Hospital were included. The treatment consisted of trimethoprim/sulfamethoxazole, rifampicin, nasal mupirocin and chlorhexidine 2%. The mean follow-up period was of 22.2 months and those with ≥3 negative cultures were considered free of methicillin-resistant Staphylococcus aureus. Forty-two patients were included. Methicillin-resistant Staphylococcus aureus was identified in six patients. Most patients had methicillin-sensitive S. aureus isolation prior to methicillin-resistant Staphylococcus aureus. Five children used the standardized treatment, none presented side effects. Only one child had a new isolation of methicillin-resistant Staphylococcus aureus during follow-up (after 20 months). The incidence of methicillin-resistant Staphylococcus aureus infection was high and occurred in young patients. The therapeutic regimen was effective, safe and being a good option to treat methicillin-resistant Staphylococcus aureus infection.

https://doi.org/10.1016/j.bjid.2016.09.003 1096 downloads

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ta	journal short title (e.g. Cad. Saúde Pública)
journal_title	journal full title (e.g. Cadernos de Saúde Pública)
la	publication language code (e.g. pt - Portuguese, es - Spanish)
type	document type
pid	publication identifier
publication_year	publication year of publication
sponsor	sponsor
aff_country	country code of the author's affiliation
aff_institution	author affiliation institution
volume	article volume
issue	article issue
elocation	elocation
doi	DOI number
issn	journal ISSN
in	SciELO colection code (e.g. scl - Brasil, col - Colômbia)
use_license	article usage license code

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