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Safety of two-dose schedule of COVID-19 adsorbed inactivated vaccine (CoronaVac; Sinovac/Butantan) and heterologous additional doses of mRNA BNT162b2 (Pfizer/BioNTech) in immunocompromised and immunocompetent individuals
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Miyaji, Karina Takesaki

; Ibrahim, Karim Yaqub

; Infante, Vanessa

; Moreira, Raquel Megale

; Santos, Carolina Ferreira dos Belizário, Juliana de Cássia Pinto, Maria Isabel de Moraes Marinho, Ana Karolina Barreto Berselli Pereira, Juliana Marquezi Mello, Liliane Saraiva de Silva, Vitor Gabriel Lopes da Sato, Paula Keiko Strabelli, Tânia Mara Varejão Ragiotto, Lucas Pacheco, Pedro Henrique Theotonio de Mesquita Braga, Patricia Emilia Loch, Ana Paula Precioso, Alexander Roberto Sartori, Ana Marli Christovam França, João Ítalo Lima, Marcos Alves de Ando, Mauricio Cesar Sampaio Rodrigues, Camila Cristina Martini Song, Alice Tung Wan Lara, Amanda Nazareth Belizário, Ana Cristina Lima, Anna Helena Simões Bortulucci de Zanetti, Ariane Cristina Barboza Paulo, Audrey Rose da Silveira Amancio de Rosa, Barbara Miranda dos Santos Moraes, Bruna Del Guerra de Carvalho Oliveira, Bruna Ribeiro de Picone, Camila de Melo Aranda, Carolina Sanches Troli, Carolinne Paioli Kokron, Cristina M. Terrabuio, Debora Raquel Benedita Abdala, Edson David Neto, Elias Nakanishi, Érika Yoshie Shimoda Lima, Fabiana Mascarenhas Souza Firmino, Fabio Batista Santos, Fernanda Barone Alves dos Bacal, Fernando Fatobene, Giancarlo Santana, Jaqueline Oliveira Kalil, Jorge Barbosa, Julia Gonçalves, Leandro Peres Otuyama, Leonardo Jun Pierrotti, Ligia Camera Compte, Livia Caroline Mariano Marinho, Livia Chaer, Livia Netto Seguro, Luis Fernando Azevedo, Luiz Sergio Ueda, Márcia Aiko Terreri, Maria Teresa Barros, Myrthes Anna Maragna Toledo Grecco, Octávio Sejas, Odeli Nicole Encinas Musqueira, Priscila Tavares Ito, Raquel Keiko de Luca Teixeira, Samia Silveira Souza Fidalgo, Serafim Costa, Silvia Figueiredo Campos, Silvia Vidal Fernandes, Tamiris Hinsching Rocha, Vanderson Geraldo Coelho, Vivian Caso

Revista do Instituto de Medicina Tropical de São Paulo

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2025, Volume 67 elocation e2

Abstract: En | Text: En | PDF: En

ABSTRACT Immunocompromised individuals were considered high-risk for severe disease due to SARS COV-2 infection. This study aimed to describe the safety of two doses of COVID-19 adsorbed inactivated vaccine (CoronaVac; Sinovac/Butantan), followed by additional doses of mRNA BNT162b2 (Pfizer/BioNTech) in immunocompromised (IC) adults, compared to immunocompetent/healthy (H) individuals. This phase 4, multicenter, open label study included solid organ transplant and hematopoietic stem cell transplant recipients, cancer patients and people with inborn errors of immunity with defects in antibody production, rheumatic, end-stage chronic kidney or liver disease, who were enrolled in the IC group. Participants received two doses of CoronaVac and additional doses of mRNA BNT162b2. Adverse reactions (AR) data were collected within seven days after each vaccination. Serious adverse events and of special interest (AESI) were monitored throughout the study. We included 241 immunocompromised and 100 immunocompetent subjects. Arthralgia, fatigue, myalgia, and nausea were more frequent in the IC group after CoronaVac. Following the first additional dose of mRNA BNT162, pain, induration, and tenderness at injection site, fatigue and myalgia were more frequent in the H group. A heart transplant recipient had a graft rejection temporally associated with the second CoronaVac dose, but there was no literature evidence of causal association. Four cases of AESI were considered related to the vaccine: three erythema multiforme after CoronaVac, all in IC participants, and one paresthesia after mRNA, in a H participant. Our findings were comparable to other studies that evaluated the safety of COVID-19 vaccines in different immunocompromised populations. Both vaccines were safe for immunocompromised participants.

https://doi.org/10.1590/s1678-9946202567002

Trend and high risk clusters for the occurrence of congenital anomalies in the State of Mato Grosso, Brazil (2008-2019)
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Groth, Bruna Rayeli

; Silva, Eliziani Gonçalves da

; Rocha, Camila Beatriz Alves da

; Freitas, Bruna Hinnah Borges Martins de

; Machado, Rafaela Benevides Ferreira

; Ferreira, Elena Alves Benevides

; Machado, Lúbia Maieles Gomes

; Santos, Emerson Soares dos

; Battisti, Iara Denise Endruweit

; Ferreira, Silvana Margarida Benevides

Revista Brasileira de Saúde Materno Infantil

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2025, Volume 25 elocation e20240111

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivos: analisar a dinâmica espaço-temporal da prevalência de anomalias congênitas em municípios de Mato Grosso (MT), Centro-Oeste brasileiro, no período de 2008 a 2019. Métodos: estudo ecológico de casos residentes em MT, no período de 2008 a 2019. Utilizou-se a Variação Percentual Anual (VPA) dos coeficientes na análise de tendência, por meio de regressão de Prais-Winsten e identificação de clusters de alto risco. Resultados: a taxa de malformação congênita no estado foi de 6,52 por 1.000 nascidos vivos, apresentando tendência estacionária (VPA= -1,02; IC95%= -2,93-0,93). A maioria das anomalias congênitas apresentou tendência estacionária, exceto do aparelho cardiovascular (VPA=13,58; IC95%= 3,60-24,52). Neonatos com ≤7 pontos do índice de Apgar no primeiro e no quinto minutos de vida, apresentaram tendência crescente (VPA=2,30; IC95%= 0,05-4,60 e VPA=4,15; IC95%= 1,52-6,65, respectivamente). A distribuição espacial teve caráter heterogêneo com as maiores taxas médias de casos entre as macrorregiões de saúde Oeste, Centro-Norte e Sul, e a varredura espaço-temporal identificou três clusters de alto risco entre 2015 e 2019, com RR de até cinco vezes maior para anomalias. Conclusão: as anomalias congênitas em MT apresentaram uma dinâmica heterogênea com áreas de alto risco específicas. A tendência crescente entre fatores maternos e neonatais destaca a necessidade de estratégias regionais de prevenção e controle.

Abstract Objectives: to analyze the spatiotemporal dynamics of the prevalence of congenital anomalies in in cities of Mato Grosso (MT), in the Mid-West of Brazil, from 2008 to 2019. Methods: an ecological study of cases in MT during the period from 2008 to 2019. The Annual Percent Change (APC) of the coefficients was used in the tendency analysis, through Prais-Winsten regression and the identification of high risk clusters. Results: the congenital malformation rate in the State was 6.52 per 1,000 live births, demonstrating a stationary tendency (APC-1.02; 95%CI= -2.93-0.93). Most congenital anomalies showed a stationary tendency, except for those of the cardiovascular system (APC=13.58; 95%CI= 3.60-24.52). Newborns with an Apgar score of ≤ 7 at the first and fifth minutes of life showed an increased tendency (APC=2.30; 95%CI=0.05-4.60 and APC=4.15; 95%CI= 1.52-6.65, respectively). The spatial distribution was heterogeneous, with the highest average rates of cases in the West, Central North, and South health macro-regions. The spatiotemporal scan identified three high risk clusters between 2015 and 2019, with a relative risk (RR) up to five times higher for anomalies. Conclusion: congenital anomalies in MT exhibited a heterogeneous dynamic with specific high risk areas, and their increasing tendency among maternal and neonatal factors highlights the need for regional prevention and control strategies.

https://doi.org/10.1590/1806-9304202500000111-en

Joint statement on evidence-based practices in mechanical ventilation: suggestions from two Brazilian medical societies
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Ferreira, Juliana Carvalho

; Vianna, Arthur Oswaldo de Abreu

; Pinheiro, Bruno Valle

; Maia, Israel Silva

; Baldisserotto, Sérgio Vasconcellos

; Isola, Alexandre Marini

; Cavalcanti, Alexandre Biasi Gama, Ana Maria Casati Nogueira da Rocha, Angelo Roncalli Miranda Oliveira, Antonio Gonçalves de Serpa Neto, Ary Farias, Augusto Manoel de Carvalho Orlando, Bianca Rodrigues Esteves, Bruno da Costa Mazza, Bruno Franco Silveira, Camila de Freitas Martins Soares Carvalho, Carlos Roberto Ribeiro de Toufen Junior, Carlos Barbas, Carmen Silvia Valente Teixeira, Cassiano Silveira, Débora Dutra da Medeiros, Denise Machado Parolo, Edino Costa, Eduardo Leite Vieira Caser, Eliana Bernadete Oliveira, Ellen Pierre de Banholzer, Eric Grieger Carvalho, Erich Vidal Amorim, Fabio Ferreira Saddy, Felipe Gonçalves, Fernanda Alves Ferreira Galas, Filomena Regina Barbosa Gomes Zanatta, Giovanna Carolina Gardini Silva, Gisele Sampaio Westphal, Glauco Adrieno Matos, Gustavo Faissol Janot de Souza, João Claudio Emmerich de Silva Junior, João Manoel Valiatti, Jorge Luis dos Santos Nascimento Junior, José Ribamar do Rocco, Jose Rodolfo Hajjar, Ludhmila Abrahão Forgiarini Junior, Luiz Alberto Malbuisson, Luiz Marcelo Sá Holanda, Marcelo Alcantara Amato, Marcelo Britto Passos Park, Marcelo Oliveira, Marco Antonio da Rosa e Reis, Marco Antonio Soares Tavares, Marcos Soares Souza, Mario Henrique Dutra de Damasceno, Marta Cristina Pauleti Lira-Batista, Marta Maria da Silva Pattacini, Max Morais Assunção, Murillo Santucci Cesar de Oliveira, Neymar Elias de Franzosi, Oellen Stuani Rocco, Patricia Rieken Macedo Caruso, Pedro Silva, Pedro Leme Mendes, Pedro Vitale Duarte, Pericles Almeida Delfino Santa Neto, Renato Fabio Alberto Della Rodrigues, Ricardo Goulart Cordioli, Ricardo Luiz Palazzo, Roberta Fittipaldi Goldwasser, Rosane Pinheiro, Sabrina dos Santos Justino, Sandra Regina Nemer, Sergio Nogueira Oliveira, Vanessa Martins de Silva, Vinicius Zacarias Maldaner da Nedel, Wagner Luis Bellissimo-Rodrigues, Wanessa Teixeira Oliveira Filho, Wilson de

Critical Care Science

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2025, Volume 37 elocation e20250242en

Abstract: En | Text: En | PDF: En

ABSTRACT Mechanical ventilation can be a life-saving intervention, but its implementation requires a multidisciplinary approach, with an understanding of its indications and contraindications due to the potential for complications. The management of mechanical ventilation should be part of the curricula during clinical training; however, trainees and practicing professionals frequently report low confidence in managing mechanical ventilation, often seeking additional sources of knowledge. Review articles, consensus statements and clinical practice guidelines have become important sources of guidance in mechanical ventilation, and although clinical practice guidelines offer rigorously developed recommendations, they take a long time to develop and can address only a limited number of clinical questions. The Associação de Medicina Intensiva Brasileira and the Sociedade Brasileira de Pneumologia e Tisiologia sponsored the development of a joint statement addressing all aspects of mechanical ventilation, which was divided into 38 topics. Seventy-five experts from all regions of Brazil worked in pairs to perform scoping reviews, searching for publications on their specific topic of mechanical ventilation in the last 20 years in the highest impact factor journals in the areas of intensive care, pulmonology, and anesthesiology. Each pair produced suggestions and considerations on their topics, which were presented to the entire group in a plenary session for modification when necessary and approval. The result was a comprehensive document encompassing all aspects of mechanical ventilation to provide guidance at the bedside. In this article, we report the methodology used to produce the document and highlight the most important suggestions and considerations of the document, which has been made available to the public in Portuguese.

https://doi.org/10.62675/2965-2774.20250242-en

Feminicídios em Minas Gerais, Brasil: da caracterização dos eventos à análise espaço-temporal
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Bahia, Camila Alves

; Pinto, Isabella Vitral

; Trindade, Carla Machado da

; Silva, Camila Mattarelli de Abreu e

; Habkouk, Patricia

; Simões, Taynãna César

; Câmara, Daniel Cardoso Portela

; Bevilacqua, Paula Dias

Cadernos de Saúde Pública

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2025, Volume 41 N. 1 elocation e00015224

Abstract: En Pt Es | Text: En Pt Es | PDF: En | PDF: Pt | PDF: Es

This study characterizes feminicides taking place in the state of Minas Gerais, Brazil, and compare the trends in feminicide and female homicide rates across the 89 health microregions of the state. A cross-sectional ecological study was conducted using data on feminicides from 2016 to 2020, consolidated by the Minas Gerais Prosecutor’s Office. Feminicide and female homicide rates per 100,000 females were estimated according to the health microregions. Public data from the Brazilian Mortality Information System were used for the estimation of female homicide rates. An analysis was conducted on microregions with high feminicide rates correlated with neighboring microregions with high and low female homicide rates, using Bivariate Moran’s Local Indice. A multivariate scan model was also applied to multiple data sets, in order to simultaneously identify clusters of feminicide and female homicide that coincided in time and space. A total of 698 feminicides were identified during the period, distributed across 19 health microregions. During the period, female homicide rates were higher than those of feminicide. Stability in the risk of feminicide and a decreasing trend in the risk of female homicides were observed across the health microregions of Minas Gerais. In 11 microregions, the number of feminicides exceeded the number of female homicides. The results highlighted weaknesses in the determination of the underlying cause of death for females, affecting the quality of homicide records.

Os objetivos deste estudo foram caracterizar os feminicídios ocorridos em Minas Gerais, Brasil, e comparar a tendência das taxas de feminicídio e homicídio de mulheres nas 89 microrregiões de saúde do estado. Foi conduzido um estudo transversal do tipo ecológico utilizando dados de feminicídios consumados ocorridos entre 2016-2020, consolidados pelo Ministério Público de Minas Gerais. Foram calculadas as taxas de feminicídio e de homicídio de mulheres por 100 mil pessoas do sexo feminino, segundo as microrregiões de saúde. Para o cálculo da última, utilizou-se os dados públicos do Sistema de Informações sobre Mortalidade. Uma análise foi feita acerca de microrregiões com altas taxas de feminicídio correlacionadas a microrregiões vizinhas e de altas e baixas taxas de homicídio de mulheres, através do Índice Local de Moran Bivariado. Também se aplicou o modelo de varredura multivariado para múltiplos conjuntos de dados, com vistas a identificar, simultaneamente, clusters de feminicídio e homicídio de mulheres que coincidiram no tempo e no espaço. Foram identificados 698 feminicídios consumados no ínterim, distribuídos em 19 microrregiões de saúde. Em todo o período, as taxas de homicídio de mulheres foram maiores que as taxas de feminicídio. Verificou-se estabilidade do risco de feminicídio e tendência decrescente do risco de homicídios de mulheres entre as microrregiões de saúde de Minas Gerais. Em 11 microrregiões, o número de feminicídios superou o número de homicídios de mulheres. Os resultados evidenciaram fragilidades na definição da causa básica de óbito de pessoas do sexo feminino, afetando a qualidade do registro dos homicídios.

El objetivo de este estudio fue caracterizar los feminicidios ocurridos en Minas Gerais, Brasil, y comparar la tendencia de las tasas de feminicidio y homicidio de mujeres en las 89 microrregiones de salud del estado. Se realizó un estudio transversal de tipo ecológico con base en datos de feminicidios consumados ocurridos entre 2016-2020, consolidados por el Ministerio Público de Minas Gerais. Las tasas de feminicidio y homicidio de mujeres se calcularon por cada 100.000 mujeres, según las microrregiones de salud. Para calcular la tasa de homicidios de mujeres, se utilizaron datos públicos del Sistema de Informaciones sobre Mortalidad. Se realizó un análisis de microrregiones con elevadas tasas de feminicidio correlacionadas con microrregiones vecinas, con altas y bajas tasas de homicidio de mujeres, utilizando el Índice Local de Moran Bivariado. También se aplicó el modelo de escaneo multivariado para múltiples conjuntos de datos, con miras a identificar, de manera simultánea, grupos de feminicidios y homicidios de mujeres que coincidieron en el tiempo y el espacio. Durante el período, se identificaron 698 feminicidios consumados, distribuidos en 19 microrregiones de salud. Durante todo el período, las tasas de homicidio de mujeres fueron más altas que las tasas de feminicidio. Se constató estabilidad en el riesgo de feminicidio y una tendencia decreciente en el riesgo de homicidios de mujeres entre las microrregiones de salud de Minas Gerais. En 11 microrregiones el número de feminicidios superó el número de homicidios de mujeres. Los resultados pusieron de manifiesto debilidades en la definición de la causa básica de muerte de las mujeres, lo que afecta la calidad del registro de homicidios.

https://doi.org/10.1590/0102-311xpt015224

COVID-19 Computed tomography patterns in renal replacement therapy patients COVID19 COVID 19 COVID-1 COVID1 1 COVID-
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Carmo, Gabriel Assis Lopes do

; Oliveira, Mariana Paiva

; Campos, Anna Luiza Lino

; Couto, Bráulio Roberto Gonçalves Marinho

; Carmo, Lilian Pires de Freitas do

; Cerqueira, Tiago Lemos

; Souza, Camila Alencar Monteiro de

; Goll, Yan Lopes Souza, Vitor Santos de Vieira, Mariana Oliveira Guimarães Castro, Pedro Alves Soares Vaz de Lemos, Pedro Augusto Botelho Silva, Ana Cristina Simões e

Brazilian Journal of Nephrology

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sep 2024, Volume 46 N. 3 elocation e20230029

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: Doenças pulmonares são comuns em pacientes com doença renal em estágio terminal (DRET), dificultando o diagnóstico diferencial com COVID-19. Este estudo descreve achados de tomografia computadorizada de tórax (TC) em pacientes com DRET em terapia renal substitutiva (TRS) hospitalizados com suspeita de COVID-19. Métodos: Indivíduos maiores de 18 anos com DRET, encaminhados ao pronto-socorro com suspeita de COVID-19 foram incluídos. Dados clínicos e epidemiológicos foram extraídos de registros eletrônicos de saúde. A TC foi classificada como típica, indeterminada, atípica, negativa. Comparamos achados tomográficos de pacientes com COVID-19 positivos e negativos. Resultados: Recrutamos 109 pacientes (62,3% COVID-19-positivos) entre março e dezembro de 2020, idade média de 60 ± 12,5 anos, 43% mulheres. A etiologia mais comum da DRET foi diabetes. Tempo médio em diálise foi 36 meses, intervalo interquartil = 12–84. A lesão pulmonar mais comum foi opacidades em vidro fosco. O padrão típico de TC foi mais comum em pacientes com COVID-19 (40 (61%) vs. 0 (0%) em pacientes sem COVID-19, p < 0,001). Sensibilidade 60,61% (40/66), especificidade 100% (40/40). Valores preditivos positivos e negativos foram 100% e 62,3%, respectivamente. Padrão atípico de TC foi mais frequente em pacientes COVID-19-negativos (9 (14%) vs. 24 (56%) em COVID-19-positivos, p < 0,001), enquanto padrão indeterminado foi semelhante em ambos os grupos (13 (20%) vs. 6 (14%), p = 0,606), e padrão negativo foi mais comum em pacientes COVID-19-negativos (4 (6%) vs. 12 (28%), p = 0,002). Conclusões: Em pacientes com DRET em TRS hospitalizados, um padrão atípico de TC de tórax não pode excluir adequadamente o diagnóstico de COVID-19. Introdução , (DRET) COVID19. COVID19 COVID 19. 19 (TC (TRS Métodos 1 prontosocorro pronto socorro COVID-1 incluídos saúde típica indeterminada atípica negativa Resultados 10 62,3% 623 62 3 (62,3 COVID19positivos COVIDpositivos COVID-19-positivos 2020 125 5 12, 43 mulheres diabetes meses 1284 84 12–84 fosco 40 61% 61 (61% vs 0% (0% COVID19, 19, 0,001. 0001 0,001 . 001 0,001) 6061 60,61 40/66, 4066 40/66 66 (40/66) 100 40/40. 4040 40/40 (40/40) respectivamente COVID19negativos COVIDnegativos 9 ( 14% 14 (14% 2 56% 56 (56% COVID19positivos, positivos, 0,001, 13 (1 20% 20 (20% 14%, 0,606, 0606 0,606 606 0,606) 4 6% (6% 28%, 28 28% (28%) 0,002. 0002 0,002 002 0,002) Conclusões (DRET COVID1 COVID- 62,3 (62, 202 128 8 12–8 (61 (0 000 0,00 00 60,6 406 40/6 (40/66 404 40/4 (40/40 (14 (56 (20 060 0,60 (6 (28% 62, (62 12– 0,0 60, 40/ (40/6 (40/4 (5 (2 06 0,6 (28 0, (40/

ABSTRACT Introduction: Lung diseases are common in patients with end stage kidney disease (ESKD), making differential diagnosis with COVID-19 a challenge. This study describes pulmonary chest tomography (CT) findings in hospitalized ESKD patients on renal replacement therapy (RRT) with clinical suspicion of COVID-19. Methods: ESKD individuals referred to emergency department older than 18 years with clinical suspicion of COVID-19 were recruited. Epidemiological baseline clinical information was extracted from electronic health records. Pulmonary CT was classified as typical, indeterminate, atypical or negative. We then compared the CT findings of positive and negative COVID-19 patients. Results: We recruited 109 patients (62.3% COVID-19-positive) between March and December 2020, mean age 60 ± 12.5 years, 43% female. The most common etiology of ESKD was diabetes. Median time on dialysis was 36 months, interquartile range = 12–84. The most common pulmonary lesion on CT was ground glass opacities. Typical CT pattern was more common in COVID-19 patients (40 (61%) vs 0 (0%) in non-COVID-19 patients, p < 0.001). Sensitivity was 60.61% (40/66) and specificity was 100% (40/40). Positive predictive value and negative predictive value were 100% and 62.3%, respectively. Atypical CT pattern was more frequent in COVID-19-negative patients (9 (14%) vs 24 (56%) in COVID-19-positive, p < 0.001), while the indeterminate pattern was similar in both groups (13 (20%) vs 6 (14%), p = 0.606), and negative pattern was more common in COVID-19-negative patients (4 (6%) vs 12 (28%), p = 0.002). Conclusions: In hospitalized ESKD patients on RRT, atypical chest CT pattern cannot adequately rule out the diagnosis of COVID-19. Introduction ESKD, , (ESKD) COVID19 COVID 19 COVID-1 challenge (CT RRT (RRT COVID19. 19. Methods 1 records typical Results 10 62.3% 623 62 3 (62.3 COVID19positive COVIDpositive COVID-19-positive 2020 125 5 12. 43 female diabetes months 1284 84 12–84 opacities 40 61% 61 (61% 0% (0% nonCOVID19 nonCOVID non non-COVID-1 0.001. 0001 0.001 . 001 0.001) 6061 60.61 40/66 4066 66 (40/66 100 40/40. 4040 40/40 (40/40) respectively COVID19negative COVIDnegative 9 ( 14% 14 (14% 2 56% 56 (56% COVID19positive, positive, 0.001, 13 (1 20% 20 (20% 14%, 0.606, 0606 0.606 606 0.606) 4 6% (6% 28%, 28 28% (28%) 0.002. 0002 0.002 002 0.002) Conclusions (ESKD COVID1 COVID- 62.3 (62. 202 128 8 12–8 (61 (0 nonCOVID1 non-COVID- 000 0.00 00 60.6 40/6 406 (40/6 404 40/4 (40/40 (14 (56 (20 060 0.60 (6 (28% 62. (62 12– non-COVID 0.0 60. 40/ (40/ (40/4 (5 (2 06 0.6 (28 0.

https://doi.org/10.1590/2175-8239-jbn-2023-0029en

Morbidity trend and space-time clusters of COVID-19 occurrence in children and adolescents spacetime space time COVID19 COVID 19 COVID-1 COVID1 1 COVID-
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Rocha, Camila Beatriz Alves da

; Machado, Lúbia Maieles Gomes

; Silva, Pãmela Rodrigues de Souza

; Freitas, Bruna Hinnah Borges Martins de

; Battisti, Iara Denise Endruweit

; Santos, Emerson Soares dos

; Ferreira, Silvana Margarida Benevides

Jornal de Pediatria

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apr 2024, Volume 100 N. 2 Pages 196 - 203

Abstract: En | Text: En | PDF: En

Abstract Objective: To analyze the morbidity trend and space-time distribution clusters of confirmed COVID-19 cases in children and adolescents. Method: An ecological study of COVID-19 cases confirmed in the Information System from 2020 to 2022 in the age group from 0 to 19 years old, residents in Mato Grosso municipalities, Brazilian Midwest region. A trend analysis of the monthly morbidity rate of cases/100,000 inhabitants was used, following Prais-Winsten’s regression. A space-time distribution of the Bayesian incidence rate per 100,000 inhabitants was performed, in addition to a space-time scan to identify high-risk clusters. Results: Of all 79,592 COVID-19 cases studied, 51.6% were in females and 44.21% in people aged 15-19 years old. The mean monthly rate was 265.87 cases per 100,000 inhabitants, with a stationary trend in the period analyzed (Monthly Percentage Variation [MPV]) = 12.15; CI95%[MPV]: -0.73;26.70). The morbidity rate due to COVID-19 was higher in the female gender (283.14/ 100,000 inhabitants) and in the age group from 15 to 19 years old (485.90/100,000 inhabitants). An increasing trend was observed with a greater monthly time variation of 14.42% (CI95%[MPV]: 1.28;29.28)] among those aged from 10 to 14 years old. The primary cluster, which was also the one with the highest Relative Risk (RR = 5,16, p-value = 0.001), included 19 municipalities located in the North health macro-region. Conclusion: The findings indicated a monthly stationary trend in the study population, an increase in the age group from 10 to 14 years old, and areas at a higher risk for the disease in the North health macro-region of the state. Objective spacetime space COVID19 COVID COVID-1 adolescents Method 202 1 region cases100000 100 000 cases/100,00 used PraisWinstens Prais Winsten s regression 100000 100,00 performed highrisk high Results 79592 79 592 79,59 studied 516 51 6 51.6 4421 44 21 44.21 1519 15-1 26587 265 87 265.8 Monthly MPV [MPV] 12.15 1215 12 CI95%MPV CI95MPV CIMPV CI95% CI95 CI CI95%[MPV] 0.7326.70. 0732670 0.73 26.70 . 73 26 70 -0.73;26.70) 283.14/ 28314 283 (283.14 485.90/100,000 48590100000 485 90 (485.90/100,00 inhabitants. 1442 42 14.42 (CI95%[MPV] 1.2829.28 1282928 1.28 29.28 28 29 1.28;29.28) cluster RR 5 16 5,16 pvalue p value 0.001, 0001 0.001 , 001 0.001) macroregion. macroregion macro Conclusion population state COVID1 COVID- 20 cases10000 00 cases/100,0 10000 100,0 7959 7 59 79,5 51. 442 4 2 44.2 151 15- 2658 8 265. [MPV 12.1 121 CI9 CI95%[MPV 7326 0.7326.70 073267 073 0.7 2670 26.7 -0.73;26.70 283.14 2831 (283.1 485.90/100,00 4859010000 48 9 (485.90/100,0 144 14.4 (CI95%[MPV 2829 1.2829.2 128292 128 1.2 2928 29.2 1.28;29.28 5,1 0.00 cases1000 cases/100, 1000 100, 795 79, 44. 12. 732 0.7326.7 07326 07 0. 267 26. -0.73;26.7 283.1 (283. 485.90/100,0 485901000 (485.90/100, 14. 282 1.2829. 12829 1. 292 29. 1.28;29.2 5, 0.0 cases100 cases/100 0.7326. 0732 -0.73;26. 283. (283 485.90/100, 48590100 (485.90/100 1.2829 1282 1.28;29. cases10 cases/10 0.7326 -0.73;26 (28 485.90/100 4859010 (485.90/10 1.282 1.28;29 cases1 cases/1 0.732 -0.73;2 (2 485.90/10 485901 (485.90/1 1.28;2 cases/ -0.73; ( 485.90/1 48590 (485.90/ 1.28; -0.73 485.90/ 4859 (485.90 -0.7 485.90 (485.9 -0. 485.9 (485. -0 485. (485 - (48 (4

https://doi.org/10.1016/j.jped.2023.10.004

Variables related to perceived stress and resilience among international migrants: a multicenter study (AFFAIR Project)
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Barreto, Mayckel da Silva

; Barbieri-Figueiredo, Maria do Céu

; Garcia-Padilla, Francisca Maria

; Mendia, Raquel Saenz

; Silva, Renan Alves

; Sá, Florinda Laura Ferreira Rodrigues Galinha De

; Almeida, Camila Aparecida Pinheiro Landim

; Campos, Maria Joana

; Lise, Fernanda

; Marcon, Sonia Silva

Revista da Escola de Enfermagem da USP

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2024, Volume 58 elocation e20240222

Abstract: Es Pt En | Text: Es Pt En | PDF: Es | PDF: Pt | PDF: En

RESUMEN Objetivo: Identificar variables relacionadas con el estrés percibido y la resiliencia de los migrantes internacionales. Método: Estudio multicéntrico, observacional y transversal, realizado con 403 inmigrantes que vivían en Brasil, España o Portugal. Para la recolección de datos se utilizaron los siguientes instrumentos: Escala de Estrés Percibido y Escala de resiliencia. En el análisis se aplicó la prueba t de Student y análisis de varianza. Resultados: El estrés percibido se relacionó con: vivir en Brasil o Portugal; estancia más corta en el país anfitrión; ser negro o marrón; y no tener religión. La mayor resiliencia estuvo relacionada con: no estar divorciado; tener menos educación y menores ingresos familiares; ser de países en desarrollo; vivir en España; y tener religión. Conclusión: Aspectos como el país de acogida y el país de origen, el color de la piel, los ingresos, el estado civil, la educación, la duración de la estancia en el país de acogida y la religión están relacionados con el nivel de estrés y/o resiliencia de los migrantes. Conocer este perfil es útil para desarrollar políticas e intervenciones públicas de integración que busquen reducir el estrés y mejorar la resiliencia

RESUMO Objetivo: Identificar as variáveis relacionadas ao estresse percebido e à resiliência de migrantes internacionais. Método: Estudo multicêntrico, observacional e de corte transversal, realizado com 403 migrantes que residiam no Brasil, Espanha ou Portugal. Para a coleta de dados foram utilizados os instrumentos: Perceived Stress Scale e Resilience Scale. Na análise foram aplicados os testes t-student e análise de variância. Resultados: O estresse percebido esteve relacionado com: viver no Brasil ou em Portugal; menor tempo de permanência no país anfitrião; ser negro ou pardo; e não ter religião. Maior resiliência relacionou-se com: não ser divorciado; ter menor escolaridade e menor renda familiar; ser originário de países em desenvolvimento; viver na Espanha; e ter religião. Conclusão: Aspectos como país de acolhimento e de origem, cor da pele, renda, estado civil, escolaridade, tempo de permanência no país anfitrião e religião estão relacionados com o nível de estresse e/ou resiliência de migrantes. Conhecer esse perfil é útil para a elaboração de políticas públicas de integração e intervenções que busquem diminuir o estresse e melhorar a resiliência.

ABSTRACT Objective: To identify variables related to perceived stress and resilience of international migrants. Method: Multicenter, observational, cross-sectional study carried out with 403 migrants residing in Brazil, Spain, or Portugal. The following instruments were used to collect data: Perceived Stress Scale and Resilience Scale. Student's t-test and analysis of variance were applied in the analysis. Results: Perceived stress was related to: living in Brazil or Portugal; shorter stay in the host country; being black or brown; and having no religion. Greater resilience was related to: not being divorced; having less education and lower family income; being from developing countries; living in Spain; and having a religion. Conclusion: Aspects such as host and origin country, skin color, income, marital status, education, length of stay in the host country, and religion are related to the level of stress and/or resilience of migrants. Knowing this profile is useful for developing public integration policies and interventions that seek to reduce stress and improve resilience.

https://doi.org/10.1590/1980-220x-reeusp-2024-0222en

Variables related to perceived stress and resilience among international migrants: a multicenter study (AFFAIR Project) migrants AFFAIR Project
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Barreto, Mayckel da Silva

; Barbieri-Figueiredo, Maria do Céu

; Garcia-Padilla, Francisca Maria

; Mendia, Raquel Saenz

; Silva, Renan Alves

; Sá, Florinda Laura Ferreira Rodrigues Galinha De

; Almeida, Camila Aparecida Pinheiro Landim

; Campos, Maria Joana

; Lise, Fernanda

; Marcon, Sonia Silva

Revista da Escola de Enfermagem da USP

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2024, Volume 58 elocation e20240222

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/1980-220x-reeusp-2024-0222en

Safety of CoronaVac and ChAdOx1 vaccines against SARS-CoV-2 in patients with rheumatoid arthritis: data from the Brazilian multicentric study safer ChAdOx SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- arthritis SARS-CoV
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Cruz, Vitor Alves

; Guimarães, Camila Rêgo, Jozelia Machado, Ketty Lysie Libardi Lira Miyamoto, Samira Tatiyama Burian, Ana Paula Neves Dias, Laiza Hombre Pretti, Flavia Zon Batista, Danielle Cristina Filgueira Alves Mill, José Geraldo Oliveira, Yasmin Gurtler Pinheiro de Gadelha, Carolina Strauss Estevez Gouveia, Maria da Penha Gomes Moulin, Anna Carolina Simões Souza, Bárbara Oliveira Aguiar, Laura Gonçalves Rodrigues Vieira, Gabriel Smith Sobral Grillo, Luiza Lorenzoni Lima, Marina Deorce de Pasti, Laís Pizzol Surlo, Heitor Filipe Faé, Filipe Moulaz, Isac Ribeiro Macabú, Mariana de Oliveira Ribeiro, Priscila Dias Cardoso Magalhães, Vanessa de Oliveira Aguiar, Mariana Freitas de Biegelmeyer, Erika Peixoto;, Flávia Maria Matos Melo Campos Kayser, Cristiane Souza, Alexandre Wagner Silva de Castro, Charlles Heldan de Moura Ribeiro, Sandra Lúcia Euzébio Telles, Camila Maria Paiva França Bühring, Juliana Lima, Raquel Lima de Santos, Sérgio Henrique Oliveira Dos Dias, Samuel Elias Basualto Melo, Natália Seixas de Sanches, Rosely Holanda da Silva Boechat, Antonio Luiz Sartori, Natália Sarzi Hax, Vanessa Dória, Lucas Denardi Rezende, Rodrigo Poubel Vieira de Baptista, Katia Lino Fortes, Natália Rodrigues Querido Melo, Ana Karla Guedes de Melo, Tâmara Santos Vieira, Rejane Maria Rodrigues de Abreu Vieira, Adah Sophia Rodrigues Kakehasi, Adriana Maria Tavares, Anna Carolina Faria Moreira Gomes Landa, Aline Teixeira de Costa, Pollyana Vitoria Thomaz da Azevedo, Valderilio Feijó Martins-Filho, Olindo Assis Peruhype-Magalhães, Vanessa Pinheiro, Marcelo de Medeiros Monticielo, Odirlei André Reis-neto, Edgard Torres Dos Ferreira, Gilda Aparecida Souza, Viviane Angelina de Teixeira-Carvalho, Andréa Xavier, Ricardo Machado Sato, Emilia Inoue Valim, Valeria Pileggi, Gecilmara Salviato Silva, Nilzio Antonio da

Advances in Rheumatology

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2024, Volume 64 elocation 58

Abstract: En | Text: En | PDF: En

Abstract Background Patients with immune-mediated rheumatic diseases (IMRDs) have been prioritized for COVID-19 vaccination to mitigate the infection severity risks. Patients with rheumatoid arthritis (RA) are at a high risk of severe COVID-19 outcomes, especially those under immunosuppression or with associated comorbidities. However, few studies have assessed the safety of the COVID-19 vaccine in patients with RA. Objective To evaluate the safety of vaccines against SARS-CoV-2 in patients with RA. Methods This data are from the study “Safety and Efficacy on COVID-19 Vaccine in Rheumatic Diseases,” a Brazilian multicentric prospective phase IV study to evaluate COVID-19 vaccine in IMRDs in Brazil. Adverse events (AEs) in patients with RA of all centers were assessed after two doses of ChAdOx1 (Oxford/AstraZeneca) or CoronaVac (Sinovac/Butantan). Stratification of postvaccination AEs was performed using a diary, filled out daily and returned at the end of 28 days for each dose. Results A total of 188 patients with RA were include, 90% female. CoronaVac was used in 109 patients and ChAdOx1 in 79. Only mild AEs were observed, mainly after the first dose. The most common AEs after the first dose were pain at the injection (46,7%), headache (39,4%), arthralgia (39,4%), myalgia (30,5%) and fatigue (26,6%), and ChAdOx1 had a higher frequency of pain at the injection (66% vs 32 %, p < 0.001) arthralgia (62% vs 22%, p < 0.001) and myalgia (45% vs 20%, p < 0.001) compared to CoronaVac. The more common AEs after the second dose were pain at the injection (37%), arthralgia (31%), myalgia (23%), headache (21%) and fatigue (18%). Arthralgia (41,4% vs 25%, p = 0.02) and pain at injection (51,4% vs 27%, p = 0.001) were more common with ChAdOx1. No serious AEs were related. With Regard to RA activity level, no significant difference was observed between the three time periods for both COVID-19 vaccines. Conclusion In the comparison between the two immunizers in patients with RA, local reactions and musculoskeletal symptoms were more frequent with ChAdOx1 than with CoronaVac, especially after the first dose. In summary, the AE occurred mainly after the first dose, and were mild, like previous data from others immunizing agents in patients with rheumatoid arthritis. Vaccination did not worsen the degree of disease activity. immunemediated immune mediated (IMRDs COVID19 COVID 19 COVID-1 risks (RA outcomes comorbidities However SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- Safety Diseases, Diseases Brazil (AEs ChAdOx Oxford/AstraZeneca OxfordAstraZeneca Oxford AstraZeneca (Oxford/AstraZeneca Sinovac/Butantan. SinovacButantan Sinovac/Butantan . Sinovac Butantan (Sinovac/Butantan) diary 18 include 90 female 10 79 46,7%, 467 46,7% , 46 7 (46,7%) 39,4%, 394 39,4% 39 4 (39,4%) 30,5% 305 30 5 (30,5% 26,6%, 266 26,6% 26 6 (26,6%) 66% 66 (66 3 % 0.001 0001 0 001 62% 62 (62 22 22% 45% 45 (45 20 20% 37%, 37 37% (37%) 31%, 31 31% (31%) 23%, 23 23% (23%) 21% 21 (21% 18%. 18% (18%) 41,4% 414 41 (41,4 25 25% 0.02 002 02 51,4% 514 51 (51,4 27 27% related level summary COVID1 1 COVID- SARS-CoV (Sinovac/Butantan 9 46,7 (46,7% 39,4 (39,4% 30,5 (30,5 26,6 (26,6% (6 0.00 000 00 (4 (37% (31% (23% (21 (18% 41,4 (41, 0.0 51,4 (51, 46, (46,7 39, (39,4 30, (30, 26, (26,6 ( (37 (31 (23 (2 (18 41, (41 0. 51, (51 (46, (39, (30 (26, (3 (1 (5 (46 (39 (26

https://doi.org/10.1186/s42358-024-00397-5

10.

Genetic variation, agronomic potential, and acylsugar content in Santa Cruz dwarf tomato after backcrossings variation potential
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Ribeiro, Ana Luisa Alves

; Maciel, Gabriel Mascarenhas Siquieroli, Ana Carolina Silva Pereira, Lucas Medeiros Silva, Nilo Cesar Queiroga Oliveira, Camila Soares de Pinto, Frederico Garcia

Crop Breeding and Applied Biotechnology

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2024, Volume 24 N. 3 elocation e48722438

Abstract: En | Text: En | PDF: En

Abstract Tomato cultivation is globally significant, demanding enhanced yields and biotic stress resilience for sustainability. Dwarf plant utilization in tomato genetic enhancement offers underexplored benefits. Yet, Santa Cruz dwarf tomato germplasm is unavailable. This study evaluated genetic dissimilarity, agronomic potential, and acylsugar content of Santa Cruz dwarf tomato plants across three successive backcrossings. Twelve advanced backcrossing populations (BC) and a commercial control (cv. Kada) were assessed, totaling 15 treatments. Agronomic traits and acylsugar content were measured, and analysis techniques were applied to assess genetic dissimilarity and backcrossing superiority. BC3 populations UFU-Sci#8, UFU-Sci#6, UFU-Sci#5, and UFU-Sci#1 excelled. Dwarf plants predominantly exhibited high leaflet acylsugar levels, suggesting potential for acquisition of hybrid with pest resistance. Notably, UFU MC TOM1 (dwarf plant) displayed significant glycine and L-serine presence, associated with various biotic stresses. These findings unveil the promising creation of dwarf Santa Cruz tomato hybrids with a broad spectrum of resistance. sustainability benefits Yet unavailable backcrossings BC (BC cv. cv (cv Kada assessed 1 treatments measured superiority UFUSci#8, UFUSci8 UFUSci Sci#8, Sci 8 UFU-Sci#8 UFUSci#6, UFUSci6 Sci#6, 6 UFU-Sci#6 UFUSci#5, UFUSci5 Sci#5, 5 UFU-Sci#5 UFUSci#1 UFUSci1 Sci#1 UFU-Sci# excelled levels resistance Notably TOM Lserine L serine presence stresses UFUSci#8 Sci8 Sci#8 UFUSci#6 Sci6 Sci#6 UFUSci#5 Sci5 Sci#5 UFUSci# Sci1 Sci# UFU-Sci

https://doi.org/10.1590/1984-70332024v24n3a33

11.

Homologous equivalence study of immunogenicity after third dose of Covid-19 vaccine (recombinant) with an interval of six months after the second dose, comparing the interval of eight and 12 weeks between the first two doses Covid19 Covid 19 Covid-1 recombinant (recombinant 1 Covid1 Covid-
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Vianna, Clarice Monteiro

; da Silva e Sá, Gloria Regina Seid, Maria Vitória Hadland Camacho, Luiz Antonio Bastos Xavier, Janaína Reis da Gama, Vitor Cardoso de Castro, Thalita da Matta dos Santos, Ewerton Alves Portela de Almeida, Camila Dias Cruz, Robson Leite de Souza Siqueira, Marilda Maia, Maria de Lourdes de Sousa Ferroco, Clara Lucy de Vasconcellos de Araújo, Mia Ferreira Tort, Luis Fernando López Caetano, Braulia Costa

Memórias do Instituto Oswaldo Cruz

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2024, Volume 119 elocation e240094

Abstract: En | Text: En | PDF: En

BACKGROUND In response to the coronavirus disease 2019 (Covid-19) pandemic, Brazil authorised the Astra Zeneca/Fiocruz vaccine in January 2021. As the Delta variant emerged in May 2021, interval between vaccine doses was adjusted. By September 2021, the Brazilian National Immunisation Program recommended a booster dose for individuals over 70, and later expanded the recommendation to all adults. OBJECTIVES Assess the equivalence of IgG antibody response against the Covid-19 S protein before and approximately 28 days after the third dose of a Covid-19 recombinant vaccine. Two groups received initial two doses with intervals of eight and 12 weeks. METHODS This is a phase IV clinical study, uncontrolled, non-randomised. The study proposes calculating the ratio of geometric means titres (GMT) 28 days after the third dose, with a target ratio of confidence interval (CI) between 0.77 and 1.3. FINDINGS In the primary endpoint, there was no equivalence between the eight- and 12-week intervals with a slight variation favouring the eight-week group. Post-third dose, both groups showed increases titres at 28 days, three months, six months and 12 months. Both groups responded similarly to Delta and Omicron BA.1, with a more significant increase for Delta. MAIN CONCLUSIONS The study showed strong and consistent immune response in all age groups receiving the Covid-19 recombinant vaccine. Third dose elicited an increase in GMT by at least three times aligned with Ministry of Health strategies emphasising Bio-Manguinhos crucial role in pandemic control in the country. 201 Covid19 Covid 19 (Covid-19 ZenecaFiocruz Zeneca Fiocruz 2021 adjusted 70 adults Covid-1 2 1 weeks uncontrolled nonrandomised. nonrandomised non randomised. randomised non-randomised (GMT CI (CI 077 0 77 0.7 13 3 1.3 endpoint 12week week eightweek group Postthird Post BA1 BA BA.1 BioManguinhos Bio Manguinhos country 20 Covid1 (Covid-1 202 7 Covid- 07 0. 1. BA. (Covid- (Covid

https://doi.org/10.1590/0074-02760240094

12.

The effects of real Estate uncertainty shocks on state-level economic dynamics statelevel state level
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Silva, Camila Maria Pernambuco Peixoto da

; Silva, Marcelo Eduardo Alves da

Estudos Econômicos (São Paulo)

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2024, Volume 54 N. 2 elocation e53575421

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Neste artigo, analisamos como os choques de incerteza no mercado imobiliário afetam a economia de diferentes estados dos EUA. Primeiramente, construímos uma medida de incerteza imobiliária para cada estado. Utilizando esta medida, estimamos um modelo Bayesiano de Vetor Autorregressivo em Painel para obter funções de resposta ao impulso a choques de incerteza imobiliária. Examinamos então quais as características estaduais podem explicar as variações nas respostas da atividade econômica a estes choques. Os nossos resultados mostram que os choques de incerteza imobiliária têm efeitos adversos sobre a atividade econômica, com intensidades variadas entre os estados. Mostramos também que os impactos adversos sobre a renda são maiores em estados com uma elevada proporção do setor financeiro, de construção e de transformação, bem como uma grande proporção de bancos pequenos. Por outro lado, estados que alocam mais recursos para políticas de bem-estar sofrem impactos menores. artigo EUA Primeiramente estado financeiro transformação pequenos lado bemestar estar menores

Abstract In this paper, we analyze how uncertainty shocks in the real estate market affect the economy of different US states. Firstly, we construct a measure of real estate uncertainty for each state. Using this measure, we estimate a Bayesian Panel Vector Autoregressive model to obtain impulse response functions to real estate uncertainty shocks. We then examine which state characteristics can explain the variations in economic activity responses to such shocks. Our results show that real estate uncertainty shocks have adverse effects on economic activity, with varying intensities across states. We also show that the adverse impacts on income are larger in states with a high share of financial, construction, and manufacturing industries, as well as a large proportion of small banks. On the other hand, states that allocate more resources to welfare policies experience lower impacts. paper Firstly financial construction industries banks hand

https://doi.org/10.1590/1980-53575421csms

13.

Hedonic analysis of the price of mangalarga marchador horses sold at auctions
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Marquez, Mahara Moreira

; Santos, Brenda Alves Alves dos Mamede, Larissa Ferreira Schultz, Erica Beatriz Silva, Natascha Almeida arques da Raineri, Camila

Acta Scientiarum. Animal Sciences

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2024, Volume 46 elocation e60913

Abstract: En | Text: En | PDF: En

ABSTRACT. The objective was to identify sets of relevant atributes for pricing Mangalarga Marchador horses at auctions and to estimate a hedonic pricing function. We analyzed 452 horses at 20 auctions. The studied variables were characteristics intrinsic to the animals and attributes that influence sale price, which were identified through generalized linear and logistic model analysis. For each additional prize and additional bid, the prices decreased by R$ 2110.00 and R$ 549.00 respectively. The individual’s maternal grandsire positively or negatively affected prices, from R$ - 86.70 to R$ + 35.50. Non-pregnant females were penalized in price by R$ 110.00 compared to non-castrated males. A bay coat added R$ 215.00 to prices when compared to chestnut animals. Online auctions added R$ 20.10 to prices and virtual auctions penalized prices by R$ 617.00. The gray coat devalues a sale by 48% and Seller 3 decreasing by 18%. We conclude that auction type, number of prizes, share sold, animal category, coat, seller, number of bids, and maternal grandsire influenced the prices of Mangalarga Marchador horses, and that coat and seller that influenced the probability of the animal being sold. ABSTRACT function 45 2 analysis bid R 211000 2110 00 2110.0 54900 549 549.0 respectively individuals individual s 8670 86 70 86.7 3550 35 50 35.50 Nonpregnant Non pregnant 11000 110 110.0 noncastrated non castrated males 21500 215 215.0 2010 10 20.1 61700 617 617.00 48 18 18% type prizes sold category bids 4 21100 211 0 2110. 5490 54 549. 867 8 7 86. 355 5 35.5 1100 11 110. 2150 21 215. 201 1 20. 6170 61 617.0 35. 6 617.

https://doi.org/10.4025/actascianimsci.v46i1.60913

14.

New insights into the use of dwarf tomato plants for pest resistance
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Maciel, Gabriel Mascarenhas

; Oliveira, Camila Soares de

; Siquieroli, Ana Carolina Silva

; Pereira, Lucas Medeiros

; Ribeiro, Ana Luisa Alves

; Pinto, Frederico Garcia

; Ikehara, Brena Rodrigues Mota

; Silva, Nilo Cesar Queiroga

; Farias, Ana Karoline Silva Rocha de

Bragantia

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2024, Volume 83 elocation e20240066

Abstract: En | Text: En | PDF: En

ABSTRACT Tomato (Solanum lycopersicum L.), a globally significant species, faces substantial economic losses due to pest insects. However, exploiting dwarf germplasm for pest resistance, particularly the UFU MC TOM1 lineage, remains underexplored. The objectives of this study were to select backcross populations from dwarf tomato plants through direct and indirect selection and to elucidate whether there are consequences in resistance level as backcross generations progress aiming at a genetic background of interest. Backcross populations 1, 2, and 3 of dwarf tomato plants were obtained. In the conducted experiment, featuring 20 treatments and four repetitions in a randomized block design, we assessed foliar injuries and herbivory through image analysis. Additionally, we quantified the content of acylsugars, conducted chromatographic analysis, and analyzed the metabolomic profile in the leaflets. Promisingly, the UFU 13_1 dwarf plant population showed potential for enhancing genetic improvement programs targeting pest insect resistance. Moreover, the progression of backcross generations yielded varied resistance levels, likely influenced by inheritance patterns and acylsugar content. The UFU MC TOM1 line, distinguished by its high acylsugar content, exhibited robust resistance against both the tomato leafminer (Tuta absoluta Meyrick 1917) and the leafminer (Liriomyza huidobrensis Blanchard). Furthermore, our analysis revealed the expression of metabolites in the UFU MC TOM1 lineage, potentially linked to various biotic and abiotic stress responses. These findings offer promising prospects for leveraging the dwarf tomato variety, UFU MC TOM1, in genetic improvement programs aimed at combating pest insects in tomatoes. Solanum L., L L. , L.) species However TOM lineage underexplored interest 1 2 obtained experiment design Additionally acylsugars leaflets Promisingly 131 13 13_ Moreover levels line Tuta 1917 Liriomyza Blanchard. Blanchard . Blanchard) Furthermore responses variety tomatoes 191 19

https://doi.org/10.1590/1678-4499.20240066

15.

Concentrations of metals in water, sediments and aquatic macrophytes in a river located in a region with a hot semi-arid climate water semiarid semi arid
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Oliveira, Camila Tâmires Alves

; Camargo, Antonio Fernando Monteiro

; Silva, Eulene Francisco da

; Henry-Silva, Gustavo Gonzaga

Acta Limnologica Brasiliensia

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- SciELO Analytics

2024, Volume 36 elocation e17

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivo i) existe diferença no grau de contaminação nas diferentes partes da bacia nos compartimentos água, sedimento e macrófitas aquáticas? e ii) os três compartimentos respondem de forma semelhante à contaminação por metais? Metódos Amostras de água, sedimento e macrófitas aquáticas (Salvinia auriculata Aubl., Pistia stratiotes L., Ludwigia helminthorrhiza (Mart.) H. Hara e Eichhornia crassipes (Mart.) Solms) foram coletadas em 10 locais de amostragem em diferentes trechos de uma bacia hidrográfica tropical. Foram determinadas as concentrações de Fe, Pb, Ni, Zn, Mn, Cr, Cu e Cd e aos resultados nós aplicamos uma Análise de Componentes Principais (ACP), separadamente para cada compartimento, para ordenar os locais de coleta. Resultados Fe e Mn mostraram maiores concentrações do que os outros metais nas plantas e no sedimento. Com exceção do Mn, a ordem dos metais foi similar na água e no sedimento. No entanto, a ACP ordenou os locais de coleta de forma diferente. Nossos resultados demonstraram que a ordenação dos locais de amostragem por concentração de metais difere entre água, sedimento e macrófitas. Conclusão Nós concluímos que avaliar a contaminação de ambientes aquáticos por metais e os efeitos da contaminação na cadeia alimentar, não basta avalia-los apenas na água e sedimento, mas também em alguma comunidade aquática. i ii Salvinia Aubl Aubl. L L. Mart. Mart (Mart. H Solms 1 tropical Pb Ni Zn Cr ACP, , (ACP) compartimento entanto diferente alimentar avalialos avalia los aquática (Mart (ACP

Abstract Aim i) is there a difference in the level of contamination in the different parts of the basin in the water, sediment and aquatic macrophytes compartments? and ii) do the three compartments respond similarly to metal contamination? Methods Samples of water, sediment and aquatic macrophytes (Salvinia auriculata Aubl., Pistia stratiotes L., Ludwigia helminthorrhiza (Mart.) H. Hara and Eichhornia crassipes (Mart.) Solms) were collected at 10 sampling sites in different stretches of a tropical hydrographic basin. We determined the metal concentrations of Fe, Pb, Ni, Zn, Mn, Cr, Cu and Cd, and to the results we applied Principal Component Analysis (PCA), separately for each compartment, to order the sampling sites. Results Fe and Mn had higher concentrations than other metals in plants and sediment. With the exception of Mn, the order of metals was similar between water and sediment. However, the PCAs ordered the sampling sites differently. Our results demonstrated that the ordering of sampling sites by metal concentrations differs among water, sediment and macrophytes. Conclusions We conclude that to evaluate the contamination of aquatic environments by metals and the effects of contamination on the food chain, it is not enough to evaluate them only in water or sediment, but also in an aquatic community. i ii Salvinia Aubl Aubl. L L. Mart. Mart (Mart. H Solms 1 Pb Ni Zn Cr Cd PCA, PCA , (PCA) compartment However differently chain community (Mart (PCA

https://doi.org/10.1590/s2179-975x6523

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