ABSTRACT Objective Consequently, in this study, we aimed to evaluate 1,203 cases of referral to a quaternary vascular surgical service, in São Paulo, Brazil, over a 6-year period, to assess the appropriate need for referral; in addition to the prevalence of surgical indications. Methods In this retrospective analysis, we reviewed the institutional records of participants referred from Basic Healthcare Units to a vascular surgical service inside the Brazilian Unified Health System, between May 2015 and December 2020. Demographic and clinical data were collected. The participants were stratified, as per the reason for referral to the vascular surgical service, previous imaging studies, and surgical treatment indications. Referral appropriateness and complementary examinations were evaluated for each disease cohort. Finally, the prevalence of cases requiring surgical treatment was defined as the outcome measure. Results Of the 1,203 referrals evaluated, venous disease was the main reason for referral (53%), followed by peripheral arterial disease (19.4%). A considerable proportion of participants had been referred without complementary imaging or after a long duration of undergoing an examination. Referrals were regarded as inappropriate in 517 (43%) cases. Of these, 32 cases (6.2%) had been referred to the vascular surgical service, as the incorrect specialty. The percentage of referred participants who ultimately underwent surgical treatment was 39.92%. Carotid (18%) and peripheral arterial diseases (18.4%) were correlated with a lower prevalence of surgical treatments. Conclusion The rate of referral appropriateness to specialized vascular care from primary care settings was low. This may represent a subutilization of quaternary surgical services, with low rates of surgical treatment. Consequently study 1203 1 203 1,20 Paulo Brazil 6year year 6 period indications analysis System 201 2020 collected stratified studies cohort Finally measure 53%, 53 53% , (53%) 19.4%. 194 19.4% . 19 4 (19.4%) examination 51 43% 43 (43% these 3 6.2% 62 2 (6.2% specialty 3992 39 92 39.92% 18% 18 (18% 18.4% 184 (18.4% treatments services 120 20 1,2 202 5 (53% 19.4 (19.4% (43 6.2 (6.2 399 9 39.92 (18 18.4 (18.4 12 1, (53 19. (19.4 (4 6. (6. 39.9 (1 18. (18. (5 (19. ( (6 39. (19

Abstract Waterborne polyurethane (WPU) coatings used for moisture protection of surfaces have been used broadly. They have been considered environmentally friendly because their synthesis releases less or no volatile organic compounds (VOCs) to the atmosphere. With the Covid-19 pandemic concerns, cleaning protocols of these surfaces have been applied and scientific knowledge about the effects of these liquids on WPU surfaces is necessary. In this work, diffusion experiments were performed using four liquids, in pure WPU and WPU filled with graphene oxide (GO). Detergent had the most severe effect on polyurethane films, causing severe cracks and weight loss. Diffusion parameters of HCl 5% and HCl 10% were greater in WPU/GO nanocomposites than in pure WPU. Mechanical tests under chemical aging showed that alcohol reduced most the tensile strength and Young modulus. Overall, GO protected the films for all liquid exposures, increasing their tensile strength and Young modulus. (WPU broadly VOCs (VOCs atmosphere Covid19 Covid 19 Covid-1 concerns necessary work GO. . (GO) loss 5 10 WPUGO modulus Overall exposures Covid1 1 Covid- (GO

ABSTRACT Epidemics and outbreaks caused by the dengue virus pose risks to populations and have high mortality rates, causing burdens and economic costs worldwide. Brazil recently experienced an explosive increase in the number of dengue cases and fatalities. Dengue is an acute febrile illness that can progress to severe forms. It affects more than 100 countries, presenting ongoing challenges in Brazil and globally since its identification. Other conditions may be overlooked or mistaken for dengue. The most important differential diagnoses are other infectious diseases and rheumatological, hematological, gastroenterological, and neurological disorders. In this article, we discuss the primary differential diagnoses of dengue and offer a literature review highlighting the key clinical differences among clinicians. This review emphasizes the critical importance of differentiating dengue fever from infectious diseases such as meningococcemia and malaria and autoimmune and rheumatological conditions such as systemic lupus erythematosus to ensure timely and appropriate management. rates worldwide fatalities forms 10 countries identification hematological gastroenterological disorders article clinicians management 1

RESUMO Contexto: Felizmente, muito se tem estudado sobre a COVID-19 em pacientes com doenças inflamatórias intestinais (DII). As evidências sugerem que esses pacientes não parecem ter risco aumentado de COVID-19 grave. Mas ainda se tem algumas incertezas com relação às manifestações clínicas da COVID-19 em portadores de doenças imunomediadas. Objetivo: Este estudo teve como objetivo descrever os principais sintomas da COVID-19 e sua frequência em pacientes com DII e avaliar o impacto dos medicamentos utilizados no tratamento das DII na apresentação clínica da COVID-19. Métodos: Pacientes adultos com DII de três hospitais públicos terciários de ensino do Ceará, Nordeste do Brasil, foram avaliados em consulta ambulatorial no período de março a dezembro de 2020. Pacientes com COVID-19 possível ou confirmada foram comparados com pacientes sem COVID-19. Além disso, as incidências de cada sintoma foram avaliadas com base no uso de medicamentos utilizados para tratamento da DII. Resultados: Foram incluídos no estudo 515 pacientes com DII: 234 com DC e 281 com RCU. Destes, 174 pacientes (34%) tinham COVID-19 possível/confirmado, dos quais 156 (90%) eram sintomáticos. Os principais sintomas foram febre (65%) e dor de cabeça (65%); sintomas gastrointestinais ocorreram em um terço dos pacientes, sendo mais frequentes do que na população geral com COVID-19. Os fatores associados a ter COVID-19 foram sexo feminino (OR 1,71, IC95%: 1,17-2,50); ter contato com caso de COVID-19, tanto intradomiciliar (OR 5,07; IC95%: 3,31-7,78) como fora do domicílio (OR 3,14; IC95%: 2,10-4,71); trabalhar fora de casa (OR 1,87; IC95%: 1,26-2,78); história familiar de COVID-19 (OR 2,29, IC95% 1,58-3,33), uso de salicilato (OR 1,71, IC95%: 1,17-4,28) e asma (OR 7,10; IC95%: 1,46-34,57). Conclusão: Pacientes com DII com alto risco de infecção por COVID-19 podem precisar evitar a terapia com salicilatos, mas mais estudos são necessários para confirmar esta associação. Contexto Felizmente COVID19 COVID 19 COVID-1 . (DII) grave imunomediadas Objetivo COVID19. 19. Métodos Ceará Brasil 2020 disso Resultados 51 23 28 RCU Destes 17 34% 34 (34% possívelconfirmado confirmado possível/confirmado 15 90% 90 (90% sintomáticos 65% 65 (65% OR 171 1 71 1,71 IC95 IC 1,172,50 117250 1,17 2,50 2 50 1,17-2,50) COVID19, 19, 5,07 507 5 07 3,317,78 331778 3,31 7,78 3 31 7 78 3,31-7,78 3,14 314 14 2,104,71 210471 2,10 4,71 10 4 2,10-4,71) 1,87 187 87 1,262,78 126278 1,26 2,78 26 1,26-2,78) 229 29 2,29 1,583,33, 158333 1,58 3,33 , 58 33 1,58-3,33) 1,174,28 117428 4,28 1,17-4,28 7,10 710 1,4634,57. 1463457 1,46 34,57 46 57 1,46-34,57) Conclusão salicilatos associação COVID1 COVID- (DII 202 (34 9 (90 6 (65 1,7 IC9 172 1,172,5 11725 117 1,1 250 2,5 1,17-2,50 5,0 0 317 3,317,7 33177 331 3,3 778 7,7 3,31-7,7 3,1 104 2,104,7 21047 210 2,1 471 4,7 2,10-4,71 1,8 18 8 262 1,262,7 12627 126 1,2 278 2,7 1,26-2,78 22 2,2 583 1,583,33 15833 158 1,5 333 1,58-3,33 1,174,2 11742 428 4,2 1,17-4,2 7,1 4634 1,4634,57 146345 146 1,4 3457 34,5 1,46-34,57 20 (3 (9 (6 1, 1,172, 1172 11 25 2, 1,17-2,5 5, 3,317, 3317 3, 77 7, 3,31-7, 2,104, 2104 21 47 4, 2,10-4,7 1,262, 1262 12 27 1,26-2,7 1,583,3 1583 1,58-3,3 1,174, 1174 42 1,17-4, 463 1,4634,5 14634 345 34, 1,46-34,5 ( 1,172 1,17-2, 3,317 3,31-7 2,104 2,10-4, 1,262 1,26-2, 1,583, 1,58-3, 1,174 1,17-4 1,4634, 1463 1,46-34, 1,17-2 3,31- 2,10-4 1,26-2 1,583 1,58-3 1,17- 1,4634 1,46-34 2,10- 1,26- 1,58- 1,463 1,46-3 1,46-

ABSTRACT Backgrounds: Fortunately, much has been studied about COVID-19 in patients with inflammatory bowel diseases (IBD). Evidence suggests that these patients do not appear to be at increased risk of severe COVID-19. However, there are still some uncertainties regarding the clinical manifestations of COVID-19 in patients with immune-mediated diseases. Objective: This study aimed to describe the main symptoms of COVID-19 and their frequency in IBD patients and evaluate the impact of the IBD therapeutic drugs on clinical presentation of COVID-19 and to determine factors associated with COVID-19 in this population. Methods: Adult patients with IBD from three tertiary-care public, teaching hospitals in Ceará, Northeastern Brazil, were evaluated during one scheduled appointment from March to December 2020. Patients with possible or confirmed COVID-19 were compared with patients without COVID-19. Furthermore, incidences of each symptom were evaluated based on the use of IBD therapeutic drugs. Results: A total of 515 patients with IBD were included in the study: 234 with CD, and 281 with UC. Of these, 174 patients (34%) had possible/confirmed COVID-19 of whom 156 (90%) were symptomatic. Main symptoms were fever (65%) and headache (65%); gastrointestinal symptoms occurred in one third of patients and were higher than COVID-19 in general population. The factors associated with having COVID-19 were female gender (OR 1.71, 95%CI: 1.17-2.50); contact at home (OR 5.07, 95%CI: 3.31-7.78) and outside the home (OR 3.14, 95%CI: 2.10-4.71) with a case of COVID-19; work outside of the home (OR 1.87, 95%CI: 1.26-2.78); family history of COVID-19 (OR 2.29, 95%CI 1.58-3.33) use of salicylate (OR 1.71, 95%CI: 1.17-4.28); and asthma (OR 7.10, 95%CI: 1.46-34.57). Conclusion: IBD patients at high risk of COVID-19 infection may need to avoid salicylate therapy but further studies are necessary to confirm this association. Backgrounds Fortunately COVID19 COVID 19 COVID-1 IBD. . (IBD) COVID19. 19. However immunemediated immune mediated Objective population Methods tertiarycare tertiary care public Ceará Brazil 2020 Furthermore Results 51 23 CD 28 UC 17 34% 34 (34% possibleconfirmed 15 90% 90 (90% symptomatic 65% 65 (65% OR 171 1 71 1.71 95CI CI 95 1.172.50 117250 1.17 2.50 2 50 1.17-2.50) 507 5 07 5.07 3.317.78 331778 3.31 7.78 3 31 7 78 3.31-7.78 314 14 3.14 2.104.71 210471 2.10 4.71 10 4 2.10-4.71 187 87 1.87 1.262.78 126278 1.26 2.78 26 1.26-2.78) 229 29 2.29 1.583.33 158333 1.58 3.33 58 33 1.58-3.33 1.174.28 117428 4.28 1.17-4.28) 710 7.10 1.4634.57. 1463457 1.46 34.57 46 57 1.46-34.57) Conclusion association COVID1 COVID- (IBD 202 (34 9 (90 6 (65 1.7 172 1.172.5 11725 117 1.1 250 2.5 1.17-2.50 0 5.0 317 3.317.7 33177 331 3.3 778 7.7 3.31-7.7 3.1 104 2.104.7 21047 210 2.1 471 4.7 2.10-4.7 18 8 1.8 262 1.262.7 12627 126 1.2 278 2.7 1.26-2.78 22 2.2 583 1.583.3 15833 158 1.5 333 1.58-3.3 1.174.2 11742 428 4.2 1.17-4.28 7.1 4634 1.4634.57 146345 146 1.4 3457 34.5 1.46-34.57 20 (3 (9 (6 1. 1.172. 1172 11 25 2. 1.17-2.5 5. 3.317. 3317 3. 77 7. 3.31-7. 2.104. 2104 21 47 4. 2.10-4. 1.262. 1262 12 27 1.26-2.7 1.583. 1583 1.58-3. 1.174. 1174 42 1.17-4.2 463 1.4634.5 14634 345 34. 1.46-34.5 ( 1.172 1.17-2. 3.317 3.31-7 2.104 2.10-4 1.262 1.26-2. 1.583 1.58-3 1.174 1.17-4. 1.4634. 1463 1.46-34. 1.17-2 3.31- 2.10- 1.26-2 1.58- 1.17-4 1.4634 1.46-34 1.17- 1.26- 1.463 1.46-3 1.46-

Resumen El objetivo de este ensayo fue reflexionar sobre la relación entre la medicina narrativa, las redes sociales y la humanización, a partir de la utilización, por parte de uno de los autores, de las redes sociales para compartición de historias vividas en el contexto de la Atención Primaria de la Salud. Surgieron preguntas sobre los modelos de atención de salud vigentes, de la escucha y de la narrativa como dispositivos de humanización del cuidado y de la emergencia de las redes sociales como potenciadoras de la práctica de salud humanizada como puntos importantes a analizar a la luz de la literatura vigente. Al final, se compartieron observaciones para la utilización de la medicina narrativa como herramienta para una práctica humanizadora. autores Salud vigentes vigente final humanizadora

Este ensaio almejou refletir sobre a relação entre medicina narrativa, redes sociais e humanização a partir da utilização, por um dos autores, das redes sociais para compartilhamentos de histórias vivenciadas no contexto da Atenção Primária à Saúde. Questões acerca dos modelos de atenção em saúde vigentes, da escuta e da narrativa como dispositivos de humanização do cuidado e da emergência das redes sociais como potencializadoras da prática de saúde humanizada surgiram como importantes pontos a serem analisados à luz da literatura vigente. Ao fim, foram compartilhados apontamentos para utilização da medicina narrativa como ferramenta para uma prática humanizadora. autores Saúde vigentes vigente fim humanizadora

Abstract This essay reflects on the relationship between narrative medicine, social media, and humanization based on the use of social media by one of the authors to share experiences in the context of primary health care. Questions about prevailing health care models, listening, and narrative as dispositives of the humanization of care and the emergence of social media as drivers of humanized health practices arose as important points that need to be analyzed in the light of current literature. In the conclusion we present some considerations relating to the use of narrative medicine as a tool for promoting humanizing practices. models listening literature

Resumen El objetivo de este ensayo fue reflexionar sobre la relación entre la medicina narrativa, las redes sociales y la humanización, a partir de la utilización, por parte de uno de los autores, de las redes sociales para compartición de historias vividas en el contexto de la Atención Primaria de la Salud. Surgieron preguntas sobre los modelos de atención de salud vigentes, de la escucha y de la narrativa como dispositivos de humanización del cuidado y de la emergencia de las redes sociales como potenciadoras de la práctica de salud humanizada como puntos importantes a analizar a la luz de la literatura vigente. Al final, se compartieron observaciones para la utilización de la medicina narrativa como herramienta para una práctica humanizadora.

Este ensaio almejou refletir sobre a relação entre medicina narrativa, redes sociais e humanização a partir da utilização, por um dos autores, das redes sociais para compartilhamentos de histórias vivenciadas no contexto da Atenção Primária à Saúde. Questões acerca dos modelos de atenção em saúde vigentes, da escuta e da narrativa como dispositivos de humanização do cuidado e da emergência das redes sociais como potencializadoras da prática de saúde humanizada surgiram como importantes pontos a serem analisados à luz da literatura vigente. Ao fim, foram compartilhados apontamentos para utilização da medicina narrativa como ferramenta para uma prática humanizadora.

Abstract This essay reflects on the relationship between narrative medicine, social media, and humanization based on the use of social media by one of the authors to share experiences in the context of primary health care. Questions about prevailing health care models, listening, and narrative as dispositives of the humanization of care and the emergence of social media as drivers of humanized health practices arose as important points that need to be analyzed in the light of current literature. In the conclusion we present some considerations relating to the use of narrative medicine as a tool for promoting humanizing practices.

Abstract This study aimed to evaluate the influence of cladode pruning on apical dominance in the production and post-harvest of pitaya fruits. The experiment was carried out at the Sítio das Pitaya do Pará, which is in the city of Tomé-Açu, State of Pará, Brazil. A randomized block design (RBD) in a 3 x 2 factorial scheme was used, with four replications for each treatment. Treatments consisted of three stand positions in the field (beginning, middle, and end of row) and two pruning regimes (with and without pruning). The interaction of factors Pruning and Stand position (P*SP) inhibited sprouting, while the Pruning factor provided heavier fruits and with a better pulp/peel ratio. Thus, cladode pruning provided benefits to plant management, production parameters, and post-harvest quality.

Resumen El objetivo de este estudio fue evaluar la influencia de la poda de cladodios sobre la dominancia apical en la producción y poscosecha de frutos de pitaya. El experimento se llevó a cabo en el Sitio Pitaya do Brasil, ubicado en el municipio de Tomé-Açu, Estado de Pará, Brasil. Se utilizó un diseño de bloques al azar (RBD) en un esquema factorial 3 x 2 con cuatro repeticiones de cada tratamiento. Los tratamientos consistieron en tres posiciones de rodales en campo (inicio, medio y final de hilera) y dos tipos de poda (con y sin poda). La interacción de los factores Poda y Posición del Stand (P*SP), inhiben la brotación, mientras que el factor Poda proporciona frutos con mayor masa y mejor relación pulpa/cáscara. Así, la poda de cladodios proporcionó beneficios para el manejo de la planta, los parámetros de producción y la calidad poscosecha.

Resumo: As novas tendências globais de consumo e transformações nas sociedades agroindustriais têm imposto novos desafios às economias vigentes. Buscando por maior competitividade, os atores do setor do vinho têm investido na diversificação e diferenciação de seus produtos por meio de estratégias como o turismo. No entanto, a incorporação do turismo em territórios típicos da produção vitivinícola, favorece a competição por espaço e recursos naturais, colocando em risco a atividade principal. Assim, o presente trabalho tem como objetivo identificar e categorizar as atividades enoturísticas presentes no território, procurando entender sua estrutura, a fim de fortalecer a prática como instrumento de competitividade e de desenvolvimento local. Para tal, foram aplicados questionários a 48 empreendimentos de enoturismo do Vale dos Vinhedos, sendo levantado seus perfis e características das atividades ofertadas. Neste contexto, observou-se uma diversificação substancial da oferta turísticas do Vale dos Vinhedos, com destaque para o crescimento das atividades vinculadas mais ao cluster turístico do que a esfera vitivinícola, desenhando uma estrutura enoturística singular. A existência de um possível desequilíbrio entre a oferta turística e a aptidão vitivinícola do Vale dos Vinhedos, cada dia mais evidente, traz à tona discussões acerca da preservação da identidade local versus as exigências dos turistas.

Abstract: The new global trends in consumption and transformations in agro-industrial societies have imposed new challenges on the current economies. Seeking greater competitiveness, the players in the wine sector have invested in the diversification and differentiation of their products through strategies such as tourism. However, the incorporation of tourism in typical territories of wine production, favors competition for space and natural resources, putting the main activity at risk. Thus, the present work aims to identify and categorize the wine tourism activities present in the territory, seeking to understand its dynamics, in order to strengthen the practice as an instrument of competitiveness and local development. To this end, a questionnaire was applied to 48 wine tourism ventures in Vale dos Vinhedos, and their profiles and characteristics of the activities offered were surveyed. In this context, there was a substantial diversification of the tourist offer in Vale dos Vinhedos, with emphasis on the growth of activities linked more to the tourist cluster than the wine sector, drawing a unique wine tourism dynamic. The existence of a possible imbalance between the tourist offer and the wine aptitude of Vale dos Vinhedos, which is increasingly evident, brings up discussions about the preservation of local identity versus the demands of tourists.

Resumen: Las nuevas tendencias globales de consumo y las transformaciones en las sociedades agroindustriales han impuesto nuevos desafíos a las economías actuales. Buscando una mayor competitividad, los actores del sector vitivinícola han apostado por la diversificación y diferenciación de sus productos a través de estrategias como el turismo. Sin embargo, la incorporación del turismo en territorios propios de la producción vitivinícola favorece la competencia por el espacio y los recursos naturales, poniendo en riesgo la actividad principal. Así, el presente trabajo tiene como objetivo identificar y categorizar las actividades enoturísticas presentes en el territorio, buscando comprender su dinámica, con el fin de fortalecer la práctica como instrumento de competitividad y desarrollo local. Para ello, se aplicó un cuestionario a 48 empresas de enoturismo del Vale dos Vinhedos, relevando sus perfiles y características de las actividades ofertadas. En este contexto, se observó una diversificación sustancial de la oferta turística del Vale dos Vinhedos, con énfasis en el crecimiento de actividades vinculadas más al clúster turístico que al ámbito vitivinícola, diseñando una dinámica enoturística única. La existencia de un posible desequilibrio entre la oferta turística y la aptitud vitivinícola del Vale dos Vinhedos, cada vez más evidente, suscita discusiones sobre la preservación de la identidad local frente a las demandas de los turistas.

Abstract Introduction: patients with COVID-19 undergo changes in leukocyte count, respiratory disorders, and an increase in inflammatory substances. To improve the inflammatory condition, some nutrients can be used, including arginine, omega-3 fatty acids and nucleotides. This study aims to evaluate how oral immunonutrient supplements affects serum C-reactive protein (CRP) levels and lymphocyte count in patients with COVID-19. Methods: in this double-blind clinical trial, we randomized 43 adult patients with COVID-19 to receive a standard high-protein normocaloric supplement (control) or an immunonutrient-enriched supplement (experiment) for 7 days. The primary outcome was to evaluate changes in total lymphocyte count and serum level of CRP. The assessment of risk and nutritional status of these patients was also performed. Results: forty-three patients with mean age of 41.5 (± 1.8) years were followed up, 39.5 % of them women. The mean body mass index was 27.6 (± 0.8) kg/m² and 58.1 % had low nutritional risk. In the experiment group, there was a CRP reduction of 23.6 (± 7.5) mg/L, while in the control branch the decrease was 14.8 (± 12.1) mg/L (p = 0.002). There was an increase in lymphocytes in the experiment group (+367.5 ± 401.8 cells/mm³) and a reduction in the control group (-282.8 ± 327.8 cells/mm³), although there was no statistical significance (p = 0.369). Relative risk (RR) of treatment in reducing CRP by 30 % or more was 4.45 (p < 0.001; 95 % CI, 1.79-11.07). RR in increasing lymphocyte count by 30 % or more was 1.28 (p = 0.327; 95 % CI, 0.67-2.45). Conclusion: we conclude that immunonutrient supplements seem to reduce CRP levels more than standard high-protein normocaloric supplements.

Resumen Introducción: los pacientes con COVID-19 sufren cambios en el recuento de leucocitos, trastornos respiratorios y aumento de sustancias inflamatorias. Para mejorar la condición inflamatoria se pueden usar algunos nutrientes, como la arginina, los ácidos grasos omega-3 y los nucleótidos. Este estudio tiene como objetivo evaluar cómo los suplementos de inmunonutrientes orales afectan a los niveles séricos de proteína C-reactiva (PCR) y al recuento de linfocitos en pacientes con COVID-19. Métodos: en este ensayo clínico doble ciego, aleatorizamos a 43 pacientes adultos con COVID-19 para recibir un suplemento normocalórico estándar alto en proteínas (control) o un suplemento enriquecido con inmunonutrientes (experimento) durante 7 días. El resultado primario fue evaluar los cambios en el recuento total de linfocitos y el nivel sérico de PCR. También se realizó la evaluación del riesgo y el estado nutricional de estos pacientes. Resultados: cuarenta y tres pacientes con edad media de 41,5 (± 1,8) años fueron seguidos, el 39,5 % de ellos mujeres. El índice de masa corporal medio fue de 27,6 (± 0,8) kg/m² y el 58,1 % tenían bajo riesgo nutricional. En el grupo experimental hubo una reducción de la PCR de 23,6 (± 7,5) mg/L, mientras que en la rama de control la disminución fue de 14,8 (± 12,1) mg/L (p = 0,002). Hubo un aumento de linfocitos en el grupo experimental (+367,5 ± 401,8 células/mm³) y una reducción en el grupo de control (-282,8 ± 327,8 células/mm³), aunque no hubo significación estadística (p = 0,369). El riesgo relativo (RR) del tratamiento para reducir la PCR en un 30 % o más fue de 4,45 (p < 0,001; IC 95 %: 1,79-11,07). El RR en el aumento del recuento de linfocitos en un 30 % o más fue de 1,28 (p = 0,327; IC 95 %: 0,67-2,45). Conclusión: se concluye que los suplementos de inmunonutrientes parecen reducir los niveles de PCR más que los suplementos normocalóricos estándar altos en proteína.

Resumo Este artigo visa compreender como barreiras individuais, nacionais e organizacionais e suas inter-relações impactam o emprego de refugiados no mercado de trabalho brasileiro, com base na teoria da estrutura relacional da gestão da diversidade de Syed e Özbilgin (2009). Por meio de um paradigma interpretativo, abordagem qualitativa e utilizando uma pesquisa descritiva, o estudo foi realizado com oito refugiados com emprego formal na cidade de São Paulo, Brasil. As descobertas do estudo indicam a prevalência de barreiras nacionais sobre a exclusão de emprego para os refugiados, podendo potencializar fatores excludentes em níveis individual e organizacional. O governo brasileiro configurou-se como um dos principais obstáculos nacionais à integração, tendo papel particularmente importante na estrutura relacional. A pesquisa apresenta suas contribuições ao defender a condição do refugiado como inerente a uma extensão da diversidade. Ao lançar luz sobre as perspectivas dos refugiados acerca da realidade organizacional brasileira, o artigo propõe soluções que visem, por parte dos formuladores de políticas e organizações, minimizar impactos que as diferentes barreiras proporcionam à integração eficaz desses grupos nas organizações brasileiras.

Abstract This article seeks to analyze how individual, national and organizational barriers and their interrelationships impact the employment of refugees in the Brazilian labor market, based on the theory of the relational structure of diversity management of Syed and Özbilgin (2009). Through an interpretative paradigm, a qualitative approach, and the use of descriptive research, this study was conducted with eight refugees formally employed in the city of São Paulo, Brazil. The findings of this study indicate the prevalence of national barriers over job exclusion for refugees, which may potentiate exclusion factors at the individual and organizational level. The Brazilian government appeared as one of the main national obstacles to integration, playing a particularly important role in the relational structure. This research presents its contributions to regard the refugee’s condition as inherent to an extension of diversity. By shedding light on the perspectives of refugees about the Brazilian organizational reality, the article proposes solutions for policy makers and organizations in order to minimize the impacts that the different barriers provide to the effective integration of these groups in Brazilian organizations.

Resumen Este artículo tiene como objetivo comprender cómo las barreras individuales, nacionales y organizacionales y sus interrelaciones impactan en el empleo de refugiados en el mercado laboral brasileño, con base en la teoría de la estructura relacional de Syed y Özbilgin (2009) de gestión de la diversidad. A través de un paradigma interpretativo, un enfoque cualitativo y utilizando una investigación descriptiva, el estudio se llevó a cabo con ocho refugiados con empleo formal en la ciudad de São Paulo, Brasil. Los hallazgos del estudio indican la prevalencia de barreras nacionales de exclusión del empleo para los refugiados, que pueden aprovechar los factores de exclusión a nivel individual y organizacional. El gobierno brasileño se ha convertido en uno de los principales obstáculos nacionales para la integración, ya que juega un papel particularmente importante en la estructura relacional. La investigación presenta sus aportes defendiendo la condición de refugiado como inherente a una extensión de la diversidad. Al arrojar luz sobre las perspectivas de los refugiados sobre la realidad organizacional brasileña, el artículo propone soluciones que apuntan, por parte de los políticos y las organizaciones, a minimizar los impactos de las diferentes barreras en la integración efectiva de estos grupos en las organizaciones brasileñas.

Abstract: Tradescantia pallida (Commelinaceae) has shown promising antibacterial, antioxidant and anticancer activities. This study aimed at extracting hexane from T. pallida (HE-TP) aerial parts to identify and quantify its volatile compounds by GC-MS and GC-FID and at evaluating its antifungal and antiproliferative activities. (E)-4-Methoxycynnamic acid (50.2%), 2,5-di-tert-butyl-1,4-benzoquinone (13.7%) and epijuvabione (10.4%) were the major components identified in HE-TP. HE-TP was incorporated into PDA medium, poured into Petri dishes and transferred to mycelial discs of pathogens. Percentages of inhibition of fungal growth were determined. HE-TP showed remarkable antifungal potential at the dose of 400 µL since it inhibited 100% of Penicillium digitatum and Sclerotinia sclerotiorum growth and 92.6% of Rhizopus stolonifer growth. Besides, HE-TP demonstrated cytotoxic activity against different human tumor cell lines with IC50 values between 231.43 and 428.76 µg/mL. Therefore, results showed that HE-TP has potential against fungi of agronomic interest and tumor cells.

Resumen El objetivo fue evaluar la correlación entre los grados-día de crecimiento (GDC), altura del dosel (AD) y índice de área foliar (IAF) para el pasto Guinea irrigado considerando la diferente combinación de las tasas de nitrógeno y boro y los ciclos de rebrote. El experimento se llevó a cabo de agosto/2017 a agosto/2018, en un experimento de campo y la región climática se clasifica como subtropical. Realizó un experimento factorial (4x3x11), con cuatro repeticiones y corrido en un diseño de bloques completamente aleatorio. Tratos: fertilización con boro: 0, 1 y 2 kg ha-1; fertilización con nitrógeno: 250, 500, 750 y 1,000 kg ha-1 distribuidos en 11 ciclos de crecimiento/corta. Hemos observado la alta correlación entre GDC y los parámetros evaluados para AD y IAF. Los resultados de nitrógeno mostraron una baja influencia en la altura del dosel y el índice de área foliar, y los resultados de boro no presentaron influencia en estos parámetros.

Abstract This study aims to evaluate the correlation among growing degree-days (GDD), canopy height (CH), and leaf area index (LAI) for Guinea grass irrigated, considering the different combinations of the nitrogen and boron rates and cycles of regrowth. The experiment was carried out from August/2017 to August/2018 in a field experiment, and the climate of the region is classified as subtropical. A randomized block design arranged in a factorial scheme (4x3x11) with four replications was used. The treatment was (i) boron fertilization: 0, 1, and 2 kg ha-1; and (ii) nitrogen fertilization: 250, 500, 750, and 1,000 kg ha-1 distributing to 11 growth/cutting cycles. We observed the high correlation between GDD and the parameters evaluated of CH and LAI. The nitrogen results showed a low influence on canopy height and the leaf area index, and boron results did not influence these parameters.

SUMMARY OBJECTIVE: Several prospective randomized trials have shown that hypofractionation has the same efficacy and safety as the conventional fractionation in the treatment of localized prostate cancer. There are many benefits of hypofractionation, including a more convenient schedule for the patients and better use of resources, which is especially important in low- and middle-income countries like Brasil. Based on these data, the Brazilian Society of Radiotherapy (Sociedade Brasileira de Radioterapia) organized this consensus to guide and support the use of hypofractionated radiotherapy for localized prostate cancer in Brasil. METHODS: The relevant literature regarding moderate hypofractionation (mHypo) and ultra-hypofractionation (uHypo) was reviewed and discussed by a group of experts from public and private centers of different parts of Brasil. Several key questions concerning clinical indications, outcomes and technological requirements for hypofractionation were discussed and voted. For each question, consensus was reached if there was an agreement of at least 75% of the panel members. RESULTS: The recommendations are described in this article. CONCLUSION: This initiative will assist Brazilian radiation oncologists and medical physicists to safely treat localized prostate cancer patients with hypofractionation.

RESUMO Objetivo analisar a autoavaliação da memória de jovens universitários. Métodos trata-se de um estudo observacional, transversal, de caráter analítico, com abordagem quantitativa. Participaram 519 estudantes, matriculados regularmente em instituições de ensino superior, com média de idade de 22,9 anos (±5,5), sendo 408 mulheres e 111 homens. Os instrumentos utilizados foram o Questionário de Memória Prospectiva e Retrospectiva - QMPR (Prospective and Retrospective Memory Questionnaire - PRMQ-10) e um questionário com informações sociodemográficas e com queixas de memória relacionadas às atividades acadêmicas. Os dados foram analisados quantitativamente, de forma descritiva e inferencial, com uso do teste Qui-quadrado, considerando o valor de p<5%. Resultados os jovens universitários relataram dificuldades frequentes de memória, em especial na prospectiva e de curto prazo. Foi visto que 46,6% dos participantes apresentaram queixas de memória e 62,8% referiram acreditar que a rotina na universidade pode provocar aumento nas falhas de memória. Na autoavaliação, verificou-se que 47,7% mencionaram dificuldades na memória prospectiva e de curto prazo e, em relação à rotina acadêmica dos universitários, 46,4% relataram dificuldades na memória retrospectiva. Conclusão há associação entre a presença de queixa e os dados da autoavaliação da memória.

ABSTRACT Purpose To investigate the memory self-assessment of university students. Methods Observational, cross-sectional, analytical study with a quantitative approach. A total of 519 students regularly enrolled in higher education institutions participated, with a mean age of 22.9 years (±5.5), being 408 women and 111 men. Data was collected through the Prospective and Retrospective Memory Questionnaire (PRMQ-10) and a questionnaire with sociodemographic information and memory complaints related to academic activities. Data were evaluated quantitatively, descriptively and inferentially, using the Chi-Squared Test with a p-value <5%. Results University students reported frequent memory difficulties, especially in the prospective and short term memory. It was found that 46.6% of the participants had memory complaints and 62.8% reported believing that routine at the university may lead to an increase in memory failure. In the self-assessment, 47.7% reported difficulties in prospective and short-term memory and, in relation to the academic routine of university students, 46.4% reported difficulties in retrospective memory. Conclusion There is an association between the presence of a memory complaint and the self-assessment of memory data.

Resumo O estudo examinou os efeitos de diferentes jogos reduzidos e condicionados (JRC): manipulando as regras táticas (posse de bola (BP) vs. marcar gols com goleiro (GS)) e o formato do campo (quadrado vs. retangular) sobre o desempenho físico e técnico em jovens jogadores de futebol. Dez jogadores do sexo masculino (idade: 12,45 ± 0,51 anos; massa corporal: 41,99 ± 7,97 kg; altura: 152,85 ± 10,3 cm) foram monitorados através do sistema de posicionamento global e os JRC gravados em vídeo. A distância percorrida em diferentes intensidades e o número de ações técnicas para os 4 diferentes JRC foram usadas para análise. O efeito dos JRC sobre o desempenho no teste de sprints de 30 m e altura do salto vertical também foram analisadas. Os JRC para GS provocaram distâncias significativamente menores em corrida de baixa intensidade (p=0.003; d=-0.95) e mais sprints (p=0.050; d=0.67) e maiores distâncias caminhando (p=0.035; d=2.60) e em sprint (p=0.029; d=0.75) comparado ao BP; (ii) o número de passes (curtos [p=0.002; d=1.10] e longos [p=0.013; d=0.82]) é maior nos JRC de BP que GS. O formato retangular permite maior ocorrência de passes longos que o modelo quadrado (p=0.036; d=0.64); (iii) o desempenho de salto vertical e velocidade não mudou (p>0.05) após os JRC. Concluindo, ações envolvendo sprints em número e distância são maiores no JRC com GS comparado ao BP, enquanto que JRC de BP favorecem o desenvolvimento do passe. Por fim, o campo retangular com BP estimula a realização de passes mais longos em jovens jogadores.

Abstract The present study examined the effects of small-sided and conditioned games (SSCGs) manipulating tactical rules (ball-possession [BP] vs goal-scoring with goalkeepers [GS]) and pitch size (square [SP] vs rectangular [RP]) on the running performance and technical skills of young soccer players. Ten male soccer players (chronological age: 12.45 ± 0.51 years; body mass: 41.99 ± 7.97 kg; height: 152.85 ± 10.03 cm) were monitored using GPS units during SSCG formats. The distance covered at different running intensities and number of technical actions were used in analyses. SSCG-induced changes in 30 m sprint and CMJ performances were also evaluated. Compared to BP, GS elicited significantly lower distances covered at low intensity running (p=0.003; d=-0.95), more sprints (p=0.050; d=0.67), and longer distances covered in terms of walking (p=0.035; d=2.60) and sprinting (p=0.029; d=0.75); (ii) number of passes (short [p=0.002; d=1.10] and long [p=0.013; d=0.82]) were more frequent during BP than GS games, while RP game format allowed for greater occurrence of long passes (p=0.036; d=0.64) than under the SP condition; (iii) jumping and sprinting performance did not change (p>0.05) using different SSCG formats. In conclusion, GS games demand more sprint running episodes in terms of number and distance covered than BP games. In addition, RP game formats can be used to increase the occurrence of longer passes in young soccer players aged 11-13 years.