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1.
Effects of Gamma Radiation on Microbial Load and Chemical Constituents from Stem Barks of Luehea ochrophylla
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Araújo, Clináscia R. R.
; Silva, Thiago M.
; Siqueira, Ezequias P.
; Kohlhoff, Markus
; Pereira, Márcio T.
; Krambrock, Klaus
; Takahashi, Jacqueline A.
; Ferreira, Dalva E. C.
; Rocha, Willian R.
; Alcântara, Antônio F. C.
.
Gamma radiation is an effective method for microbial decontamination of plant materials. However, this treatment can induce changes in the chemical structure of plant constituents. Stem barks of Luehea ochrophylla were exposed to different doses of gamma radiation to evaluate decontamination efficiency and changes in chemical composition of plant material including phenolic fraction. The major microbial contaminants of non-irradiated samples were isolated and identified as the fungal species Eurotium chevalieri L. Mangin and Lecythophora decumbens. The dose of 5.0 kGy was effective to achieve total decontamination of the stem barks of L. ochrophylla. The formation of free radicals was verified in the plant material using electron paramagnetic resonance spectroscopy, and was supposed to be related to the trans-aconitic acid, a plant constituent. It was the only secondary metabolite to have its concentration significantly altered with radiation in phenolic fraction, as observed by liquid chromatography with diode array detector coupled to mass spectroscopy (LC-DAD-MS). The trans-aconitic acid was isolated and exposed to gamma radiation in aqueous medium. Its concentration decreased after exposition to a dose of 3.0 kGy, corroborating the supposition of its degradation. Citric acid was the main radiolytic product formed by irradiation of trans-aconitic acid in the presence of water. materials However constituents fraction nonirradiated non irradiated L decumbens 50 5 0 5. transaconitic trans aconitic constituent LCDADMS. LCDADMS LC DAD MS . (LC-DAD-MS) medium 30 3 3. degradation water (LC-DAD-MS
2.
Social support and suicidality during the COVID-2019 pandemic among Brazilian health care workers: longitudinal assessment of a repeated cross-sectional online survey COVID2019 COVID 2019 COVID-201 workers crosssectional cross sectional COVID201 201 COVID-20 COVID20 20 COVID-2 COVID2 2 COVID-
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Diaz, Alexandre Paim
; Pinto, Andre Braule
; Araújo, Maria Isabel Chaves
; Joaquim, Rui Mateus
; Costa, Danielle de Souza
; Serpa, Alexandre Luiz de Oliveira
; Pisani, Anthony R.
; Conwell, Yeates
; Miranda, Debora M.
; Malloy-Diniz, Leandro F.
; da Silva, Antonio G.
.
Objective: The risk of suicide is higher among health care workers than other workers. This study investigated the association between social support and suicidal ideation and behavior during the COVID-19 pandemic among Brazilian health care workers. Methods: This study used data from 10,885 respondents to the first (time point 1 – between May and June of 2020) and second (time point 2 – between December 2020 and February 2021) cross-sectional online surveys about mental health and quality of life among Brazilian health care workers during the COVID-19 pandemic. The relationship between social support as the independent variable (time point 1) and suicidal ideation and behavior as the outcomes (time point 2) was investigated through logistic regression analysis. Results: Greater social support was associated with a significantly lower risk of reporting suicidal ideation and behavior in the month prior to follow-up assessment (adjusted OR: 0.71, 95%CI 0.66-0.76 and adjusted OR 0.61, 95%CI 0.54-0.68, respectively). These associations were independent of sex, age, feelings of loneliness, and self-reported psychiatric disorders. Conclusion: Social support is associated with a lower risk of suicidality among health care workers, and its protective role appears more closely related to suicidal behavior. Objective COVID19 COVID 19 COVID-1 Methods 10885 10 885 10,88 time 202 2021 crosssectional cross sectional analysis Results followup follow up 071 0 71 0.71 95CI CI 95 0.660.76 066076 0.66 0.76 66 76 0.66-0.7 061 61 0.61 0.540.68, 054068 0.54 0.68, 54 68 0.54-0.68 respectively. respectively . respectively) sex age loneliness selfreported self reported disorders Conclusion COVID1 COVID- 1088 88 10,8 20 07 7 0.7 9 660 0.660.7 06607 066 0.6 076 6 0.66-0. 06 540 0.540.68 05406 054 0.5 068 0.68 5 0.54-0.6 108 8 10, 0. 0.660. 0660 0.66-0 0.540.6 0540 05 0.54-0. 0.660 0.66- 0.540. 0.54-0 0.540 0.54-
3.
Brazilian Psychiatric Association treatment guidelines for generalized anxiety disorder: perspectives on pharmacological and psychotherapeutic approaches disorder
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Baldaçara, Leonardo
; Paschoal, Ana Beatriz
; Pinto, Aldo Felipe
; Loureiro, Fabiano Franca
; Antonio, Luiz Antonio Vesco Gaiotto
; Veiga, Diogo de Lacerda
; Almeida, Thales Marcon
; dos Santos, Diogo Cesar
; Malloy-Diniz, Leandro Fernandes
; de Mello, Marcelo Feijó
; de Mello, Andrea Feijó
; Sanches, Marsal
; Gandarela, Lucas Marques
; Bernik, Márcio Antonini
; Nardi, Antonio E.
; da Silva, Antônio Geraldo
; Uchida, Ricardo R.
.
Generalized anxiety disorder is a highly prevalent mental disorder. Previous data indicate that more than 18 million Brazilians suffer from this condition. Traditionally, generalized anxiety disorder has been considered a mild mental health disorder, despite its links to lower life expectancy, cardiovascular disease, and suicide. The aim of this article is to combine elements of systematic and critical reviews to produce a synthesis of the best evidence about generalized anxiety disorder treatment. Systematic reviews, meta-analyses, and randomized controlled trials were included. The descriptor used in the search was “generalized anxiety disorder,” which resulted in 4,860 articles and seven other studies, of which 59 were selected. Antidepressants and benzodiazepines were indicated, as was pregabalin, and atypical antipsychotics, such as quetiapine, have been studied. Individual cognitive behavior therapy (third wave) has proven effective. There is extensive literature on many effective treatments for generalized anxiety disorder. The present review summarizes the therapeutic possibilities, emphasizing those available in Brazil. Further studies are needed to compare other available medications, assess psychotherapies and new treatments in greater depth, as well as to assess the ideal duration of therapy. Registration number: PROSPERO CRD42021288323. 1 condition Traditionally expectancy disease suicide treatment metaanalyses, metaanalyses meta analyses, analyses meta-analyses included 4860 4 860 4,86 5 selected indicated pregabalin antipsychotics quetiapine studied third wave possibilities Brazil medications depth number CRD42021288323 CRD 486 86 4,8 CRD4202128832 48 8 4, CRD420212883 CRD42021288 CRD4202128 CRD420212 CRD42021 CRD4202 CRD420 CRD42 CRD4
4.
Combinatorial Synthesis of Chiral Esters from Fruit Aroma in Continuous-Flow Reactors by Chemical and Enzymatic Catalysis ContinuousFlow Continuous Flow
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Melo, Calionara Waleska B.
; Santana, Yasmin O.
; Silva, Rodrigo M. V.
; Bezerra, Marco Antônio M.
; Bizzo, Humberto R.
; Souza, Rodrigo Octavio M. A.
; Leão, Raquel Ana C.
; Rezende, Claudia M.
.
Short-chain chiral esters are important constituents in natural fruit flavors, as well as in food and pharmaceutical industries. Different chemical and bio-catalytic routes are used for their synthesis, but the use of simultaneous techniques has not been much explored, as combinatorial synthesis and bio-catalysis in continuous-flow systems. Here, the objective was to synthesize chiral esters typically found in fruit flavors, to obtain chemical libraries with high conversion and enantiomeric excess, using combinations of these three techniques. Combinatorial synthesis in continuous-flow coil-type reactors with fix bed was used in the esterification of the secondary alcohols 2-butanol (1a), 2-pentanol (1b), 3-hexanol (1c), 2-heptanol (1d) and 2-octanol (1e) with acetic (2) and propanoic (3) acids. A surface-response method was applied to optimize the reaction conditions. Conversions were above 88% after 60 min for the reaction with chemical catalysts in continuous-flow reactors compared to 85%, but after 120 min, when conventional batch processes were used. By applying a biocatalyst, a chemical library of R acetates was prepared, with conversions over 48% after 48 h for batch and 40% after only 70 min for continuous flow reactions. It was observed that both enzymatic and homogeneous chemical catalysis showed to be viable for the chiral esters. Shortchain Short chain flavors industries biocatalytic bio catalytic explored biocatalysis continuousflow systems Here excess coiltype coil type 2butanol butanol 2 1a, 1a , (1a) 2pentanol pentanol 1b, 1b b (1b) 3hexanol hexanol 3 1c, 1c c (1c) 2heptanol heptanol 1d d (1d 2octanol octanol 1e e (1e (2 (3 acids surfaceresponse surface response conditions 88 6 85 85% 12 biocatalyst prepared 4 40 7 reactions (1a (1b (1c ( 8 1
5.
Bioactive TiO2 Fibers Prepared by Solution Blow Spinning: A Promising Approach for Microbial Control TiO Spinning
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Gimenes, Tiago Cesar
; Padovani, Guilherme Schiavão
; Silva, Eloisa Aparecida Carvalho
; Silva, Higor de Souza
; Meira, Gabriel Menegolo De Castro
; Sanches, Alex Otávio
; Malmonge, José Antônio
; Gualdi, Alexandre J.
; Paula, Fernando R. de
.
PEO/TiP fibers were obtained using the Solution Blow Spinning (SBS) apparatus and heat treated to produce TiO2 fibers. The morphological and structural characteristics were assessed using SEM and X-ray diffraction. The fibers, with a thickness of 12 μm, showed a change in crystalline structure with heat treatment. At temperatures as low as 800 °C, only the anatase phase was identified, while at 900 °C, both anatase and rutile phases coexisted. The addition of TiP to the polymer matrix reduced the initial breakdown temperature, and the DSC curves showed exothermic peaks due to the amorphous phase transition to TiO2/anatase. The fibers' photocatalytic capacity was tested, revealing that TiO2-fibers in the anatase phase achieved 97% degradation of Rhodamine-B dye in 40 minutes. The study found that the biocide efficacy of TiO2-fibers depends on their heat treatment. Fibers with anatase/rutile or pure rutile phases did not show significant efficiency. However, fibers treated at 600°C with pure anatase phase were more effective in eliminating E. coli and total coliforms. Finally, we can state that the TiO2 fibers obtained in this work using the SBS technique can be used to produce filters to purify water contaminated by pathogens dangerous to human health or even to purify the air. PEOTiP PEO (SBS TiO Xray X ray diffraction 1 μm treatment 80 C °C identified 90 coexisted temperature TiO2anatase TiOanatase TiO2/anatase tested TiO2fibers TiOfibers 97 RhodamineB Rhodamine B 4 minutes anataserutile efficiency However 600C 600 E coliforms Finally air 8 9 60 6
6.
Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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Boeger, Walter A.
; Valim, Michel P.
; Zaher, Hussam
; Rafael, José A.
; Forzza, Rafaela C.
; Percequillo, Alexandre R.
; Serejo, Cristiana S.
; Garraffoni, André R.S.
; Santos, Adalberto J.
; Slipinski, Adam
; Linzmeier, Adelita M.
; Calor, Adolfo R.
; Garda, Adrian A.
; Kury, Adriano B.
; Fernandes, Agatha C.S.
; Agudo-Padrón, Aisur I.
; Akama, Alberto
; Silva Neto, Alberto M. da
; Burbano, Alejandro L.
; Menezes, Aleksandra
; Pereira-Colavite, Alessandre
; Anichtchenko, Alexander
; Lees, Alexander C.
; Bezerra, Alexandra M.R.
; Domahovski, Alexandre C.
; Pimenta, Alexandre D.
; Aleixo, Alexandre L.P.
; Marceniuk, Alexandre P.
; Paula, Alexandre S. de
; Somavilla, Alexandre
; Specht, Alexandre
; Camargo, Alexssandro
; Newton, Alfred F.
; Silva, Aline A.S. da
; Santos, Aline B. dos
; Tassi, Aline D.
; Aragão, Allan C.
; Santos, Allan P.M.
; Migotto, Alvaro E.
; Mendes, Amanda C.
; Cunha, Amanda
; Chagas Júnior, Amazonas
; Sousa, Ana A.T. de
; Pavan, Ana C.
; Almeida, Ana C.S.
; Peronti, Ana L.B.G.
; Henriques-Oliveira, Ana L.
; Prudente, Ana L.
; Tourinho, Ana L.
; Pes, Ana M.O.
; Carmignotto, Ana P.
; Wengrat, Ana P.G. da Silva
; Dornellas, Ana P.S.
; Molin, Anamaria Dal
; Puker, Anderson
; Morandini, André C.
; Ferreira, André da S.
; Martins, André L.
; Esteves, André M.
; Fernandes, André S.
; Roza, André S.
; Köhler, Andreas
; Paladini, Andressa
; Andrade, Andrey J. de
; Pinto, Ângelo P.
; Salles, Anna C. de A.
; Gondim, Anne I.
; Amaral, Antonia C.Z.
; Rondón, Antonio A.A.
; Brescovit, Antonio
; Lofego, Antônio C.
; Marques, Antonio C.
; Macedo, Antonio
; Andriolo, Artur
; Henriques, Augusto L.
; Ferreira Júnior, Augusto L.
; Lima, Aurino F. de
; Barros, Ávyla R. de A.
; Brito, Ayrton do R.
; Romera, Bárbara L.V.
; Vasconcelos, Beatriz M.C. de
; Frable, Benjamin W.
; Santos, Bernardo F.
; Ferraz, Bernardo R.
; Rosa, Brunno B.
; Sampaio, Brunno H.L.
; Bellini, Bruno C.
; Clarkson, Bruno
; Oliveira, Bruno G. de
; Corrêa, Caio C.D.
; Martins, Caleb C.
; Castro-Guedes, Camila F. de
; Souto, Camilla
; Bicho, Carla de L.
; Cunha, Carlo M.
; Barboza, Carlos A. de M.
; Lucena, Carlos A.S. de
; Barreto, Carlos
; Santana, Carlos D.C.M. de
; Agne, Carlos E.Q.
; Mielke, Carlos G.C.
; Caetano, Carlos H.S.
; Flechtmann, Carlos H.W.
; Lamas, Carlos J.E.
; Rocha, Carlos
; Mascarenhas, Carolina S.
; Margaría, Cecilia B.
; Waichert, Cecilia
; Digiani, Celina
; Haddad, Célio F.B.
; Azevedo, Celso O.
; Benetti, Cesar J.
; Santos, Charles M.D. dos
; Bartlett, Charles R.
; Bonvicino, Cibele
; Ribeiro-Costa, Cibele S.
; Santos, Cinthya S.G.
; Justino, Cíntia E.L.
; Canedo, Clarissa
; Bonecker, Claudia C.
; Santos, Cláudia P.
; Carvalho, Claudio J.B. de
; Gonçalves, Clayton C.
; Galvão, Cleber
; Costa, Cleide
; Oliveira, Cléo D.C. de
; Schwertner, Cristiano F.
; Andrade, Cristiano L.
; Pereira, Cristiano M.
; Sampaio, Cristiano
; Dias, Cristina de O.
; Lucena, Daercio A. de A.
; Manfio, Daiara
; Amorim, Dalton de S.
; Queiroz, Dalva L. de
; Queiroz, Dalva L. de
; Colpani, Daniara
; Abbate, Daniel
; Aquino, Daniel A.
; Burckhardt, Daniel
; Cavallari, Daniel C.
; Prado, Daniel de C. Schelesky
; Praciano, Daniel L.
; Basílio, Daniel S.
; Bená, Daniela de C.
; Toledo, Daniela G.P. de
; Takiya, Daniela M.
; Fernandes, Daniell R.R.
; Ament, Danilo C.
; Cordeiro, Danilo P.
; Silva, Darliane E.
; Pollock, Darren A.
; Muniz, David B.
; Gibson, David I.
; Nogueira, David S.
; Marques, Dayse W.A.
; Lucatelli, Débora
; Garcia, Deivys M.A.
; Baêta, Délio
; Ferreira, Denise N.M.
; Rueda-Ramírez, Diana
; Fachin, Diego A.
; Souza, Diego de S.
; Rodrigues, Diego F.
; Pádua, Diego G. de
; Barbosa, Diego N.
; Dolibaina, Diego R.
; Amaral, Diogo C.
; Chandler, Donald S.
; Maccagnan, Douglas H.B.
; Caron, Edilson
; Carvalho, Edrielly
; Adriano, Edson A.
; Abreu Júnior, Edson F. de
; Pereira, Edson H.L.
; Viegas, Eduarda F.G.
; Carneiro, Eduardo
; Colley, Eduardo
; Eizirik, Eduardo
; Santos, Eduardo F. dos
; Shimbori, Eduardo M.
; Suárez-Morales, Eduardo
; Arruda, Eliane P. de
; Chiquito, Elisandra A.
; Lima, Élison F.B.
; Castro, Elizeu B. de
; Orlandin, Elton
; Nascimento, Elynton A. do
; Razzolini, Emanuel
; Gama, Emanuel R.R.
; Araujo, Enilma M. de
; Nishiyama, Eric Y.
; Spiessberger, Erich L.
; Santos, Érika C.L. dos
; Contreras, Eugenia F.
; Galati, Eunice A.B.
; Oliveira Junior, Evaldo C. de
; Gallardo, Fabiana
; Hernandes, Fabio A.
; Lansac-Tôha, Fábio A.
; Pitombo, Fabio B.
; Dario, Fabio Di
; Santos, Fábio L. dos
; Mauro, Fabio
; Nascimento, Fabio O. do
; Olmos, Fabio
; Amaral, Fabio R.
; Schunck, Fabio
; Godoi, Fábio S. P. de
; Machado, Fabrizio M.
; Barbo, Fausto E.
; Agrain, Federico A.
; Ribeiro, Felipe B.
; Moreira, Felipe F.F.
; Barbosa, Felipe F.
; Silva, Fenanda S.
; Cavalcanti, Fernanda F.
; Straube, Fernando C.
; Carbayo, Fernando
; Carvalho Filho, Fernando
; Zanella, Fernando C.V.
; Jacinavicius, Fernando de C.
; Farache, Fernando H.A.
; Leivas, Fernando
; Dias, Fernando M.S.
; Mantellato, Fernando
; Vaz-de-Mello, Fernando Z.
; Gudin, Filipe M.
; Albuquerque, Flávio
; Molina, Flavio B.
; Passos, Flávio D.
; Shockley, Floyd W.
; Pinheiro, Francielly F.
; Mello, Francisco de A.G. de
; Nascimento, Francisco E. de L.
; Franco, Francisco L.
; Oliveira, Francisco L. de
; Melo, Francisco T. de V.
; Quijano, Freddy R.B.
; Salles, Frederico F.
; Biffi, Gabriel
; Queiroz, Gabriel C.
; Bizarro, Gabriel L.
; Hrycyna, Gabriela
; Leviski, Gabriela
; Powell, Gareth S.
; Santos, Geane B. dos
; Morse, Geoffrey E.
; Brown, George
; Mattox, George M.T.
; Zimbrão, Geraldo
; Carvalho, Gervásio S.
; Miranda, Gil F.G.
; Moraes, Gilberto J. de
; Lourido, Gilcélia M.
; Neves, Gilmar P.
; Moreira, Gilson R.P.
; Montingelli, Giovanna G.
; Maurício, Giovanni N.
; Marconato, Gláucia
; Lopez, Guilherme E.L.
; Silva, Guilherme L. da
; Muricy, Guilherme
; Brito, Guilherme R.R.
; Garbino, Guilherme S.T.
; Flores, Gustavo E.
; Graciolli, Gustavo
; Libardi, Gustavo S.
; Proctor, Heather C.
; Gil-Santana, Helcio R.
; Varella, Henrique R.
; Escalona, Hermes E.
; Schmitz, Hermes J.
; Rodrigues, Higor D.D.
; Galvão Filho, Hilton de C.
; Quintino, Hingrid Y.S.
; Pinto, Hudson A.
; Rainho, Hugo L.
; Miyahira, Igor C.
; Gonçalves, Igor de S.
; Martins, Inês X.
; Cardoso, Irene A.
; Oliveira, Ismael B. de
; Franz, Ismael
; Fernandes, Itanna O.
; Golfetti, Ivan F.
; S. Campos-Filho, Ivanklin
; Oliveira, Ivo de S.
; Delabie, Jacques H.C.
; Oliveira, Jader de
; Prando, Jadila S.
; Patton, James L.
; Bitencourt, Jamille de A.
; Silva, Janaina M.
; Santos, Jandir C.
; Arruda, Janine O.
; Valderrama, Jefferson S.
; Dalapicolla, Jeronymo
; Oliveira, Jéssica P.
; Hájek, Jiri
; Morselli, João P.
; Narita, João P.
; Martin, João P.I.
; Grazia, Jocélia
; McHugh, Joe
; Cherem, Jorge J.
; Farias Júnior, José A.S.
; Fernandes, Jose A.M.
; Pacheco, José F.
; Birindelli, José L.O.
; Rezende, José M.
; Avendaño, Jose M.
; Duarte, José M. Barbanti
; Ribeiro, José R. Inácio
; Mermudes, José R.M.
; Pujol-Luz, José R.
; Santos, Josenilson R. dos
; Câmara, Josenir T.
; Teixeira, Joyce A.
; Prado, Joyce R. do
; Botero, Juan P.
; Almeida, Julia C.
; Kohler, Julia
; Gonçalves, Julia P.
; Beneti, Julia S.
; Donahue, Julian P.
; Alvim, Juliana
; Almeida, Juliana C.
; Segadilha, Juliana L.
; Wingert, Juliana M.
; Barbosa, Julianna F.
; Ferrer, Juliano
; Santos, Juliano F. dos
; Kuabara, Kamila M.D.
; Nascimento, Karine B.
; Schoeninger, Karine
; Campião, Karla M.
; Soares, Karla
; Zilch, Kássia
; Barão, Kim R.
; Teixeira, Larissa
; Sousa, Laura D. do N.M. de
; Dumas, Leandro L.
; Vieira, Leandro M.
; Azevedo, Leonardo H.G.
; Carvalho, Leonardo S.
; Souza, Leonardo S. de
; Rocha, Leonardo S.G.
; Bernardi, Leopoldo F.O.
; Vieira, Letícia M.
; Johann, Liana
; Salvatierra, Lidianne
; Oliveira, Livia de M.
; Loureiro, Lourdes M.A. El-moor
; Barreto, Luana B.
; Barros, Luana M.
; Lecci, Lucas
; Camargos, Lucas M. de
; Lima, Lucas R.C.
; Almeida, Lucia M.
; Martins, Luciana R.
; Marinoni, Luciane
; Moura, Luciano de A.
; Lima, Luciano
; Naka, Luciano N.
; Miranda, Lucília S.
; Salik, Lucy M.
; Bezerra, Luis E.A.
; Silveira, Luis F.
; Campos, Luiz A.
; Castro, Luiz A.S. de
; Pinho, Luiz C.
; Silveira, Luiz F.L.
; Iniesta, Luiz F.M.
; Tencatt, Luiz F.C.
; Simone, Luiz R.L.
; Malabarba, Luiz R.
; Cruz, Luiza S. da
; Sekerka, Lukas
; Barros, Lurdiana D.
; Santos, Luziany Q.
; Skoracki, Maciej
; Correia, Maira A.
; Uchoa, Manoel A.
; Andrade, Manuella F.G.
; Hermes, Marcel G.
; Miranda, Marcel S.
; Araújo, Marcel S. de
; Monné, Marcela L.
; Labruna, Marcelo B.
; Santis, Marcelo D. de
; Duarte, Marcelo
; Knoff, Marcelo
; Nogueira, Marcelo
; Britto, Marcelo R. de
; Melo, Marcelo R.S. de
; Carvalho, Marcelo R. de
; Tavares, Marcelo T.
; Kitahara, Marcelo V.
; Justo, Marcia C.N.
; Botelho, Marcia J.C.
; Couri, Márcia S.
; Borges-Martins, Márcio
; Felix, Márcio
; Oliveira, Marcio L. de
; Bologna, Marco A.
; Gottschalk, Marco S.
; Tavares, Marcos D.S.
; Lhano, Marcos G.
; Bevilaqua, Marcus
; Santos, Marcus T.T.
; Domingues, Marcus V.
; Sallum, Maria A.M.
; Digiani, María C.
; Santarém, Maria C.A.
; Nascimento, Maria C. do
; Becerril, María de los A.M.
; Santos, Maria E.A. dos
; Passos, Maria I. da S. dos
; Felippe-Bauer, Maria L.
; Cherman, Mariana A.
; Terossi, Mariana
; Bartz, Marie L.C.
; Barbosa, Marina F. de C.
; Loeb, Marina V.
; Cohn-Haft, Mario
; Cupello, Mario
; Martins, Marlúcia B.
; Christofersen, Martin L.
; Bento, Matheus
; Rocha, Matheus dos S.
; Martins, Maurício L.
; Segura, Melissa O.
; Cardenas, Melissa Q.
; Duarte, Mércia E.
; Ivie, Michael A.
; Mincarone, Michael M.
; Borges, Michela
; Monné, Miguel A.
; Casagrande, Mirna M.
; Fernandez, Monica A.
; Piovesan, Mônica
; Menezes, Naércio A.
; Benaim, Natalia P.
; Reategui, Natália S.
; Pedro, Natan C.
; Pecly, Nathalia H.
; Ferreira Júnior, Nelson
; Silva Júnior, Nelson J. da
; Perioto, Nelson W.
; Hamada, Neusa
; Degallier, Nicolas
; Chao, Ning L.
; Ferla, Noeli J.
; Mielke, Olaf H.H.
; Evangelista, Olivia
; Shibatta, Oscar A.
; Oliveira, Otto M.P.
; Albornoz, Pablo C.L.
; Dellapé, Pablo M.
; Gonçalves, Pablo R.
; Shimabukuro, Paloma H.F.
; Grossi, Paschoal
; Rodrigues, Patrícia E. da S.
; Lima, Patricia O.V.
; Velazco, Paul
; Santos, Paula B. dos
; Araújo, Paula B.
; Silva, Paula K.R.
; Riccardi, Paula R.
; Garcia, Paulo C. de A.
; Passos, Paulo G.H.
; Corgosinho, Paulo H.C.
; Lucinda, Paulo
; Costa, Paulo M.S.
; Alves, Paulo P.
; Roth, Paulo R. de O.
; Coelho, Paulo R.S.
; Duarte, Paulo R.M.
; Carvalho, Pedro F. de
; Gnaspini, Pedro
; Souza-Dias, Pedro G.B.
; Linardi, Pedro M.
; Bartholomay, Pedro R.
; Demite, Peterson R.
; Bulirsch, Petr
; Boll, Piter K.
; Pereira, Rachel M.M.
; Silva, Rafael A.P.F.
; Moura, Rafael B. de
; Boldrini, Rafael
; Silva, Rafaela A. da
; Falaschi, Rafaela L.
; Cordeiro, Ralf T.S.
; Mello, Ramon J.C.L.
; Singer, Randal A.
; Querino, Ranyse B.
; Heleodoro, Raphael A.
; Castilho, Raphael de C.
; Constantino, Reginaldo
; Guedes, Reinaldo C.
; Carrenho, Renan
; Gomes, Renata S.
; Gregorin, Renato
; Machado, Renato J.P.
; Bérnils, Renato S.
; Capellari, Renato S.
; Silva, Ricardo B.
; Kawada, Ricardo
; Dias, Ricardo M.
; Siewert, Ricardo
; Brugnera, Ricaro
; Leschen, Richard A.B.
; Constantin, Robert
; Robbins, Robert
; Pinto, Roberta R.
; Reis, Roberto E. dos
; Ramos, Robson T. da C.
; Cavichioli, Rodney R.
; Barros, Rodolfo C. de
; Caires, Rodrigo A.
; Salvador, Rodrigo B.
; Marques, Rodrigo C.
; Araújo, Rodrigo C.
; Araujo, Rodrigo de O.
; Dios, Rodrigo de V.P.
; Johnsson, Rodrigo
; Feitosa, Rodrigo M.
; Hutchings, Roger W.
; Lara, Rogéria I.R.
; Rossi, Rogério V.
; Gerstmeier, Roland
; Ochoa, Ronald
; Hutchings, Rosa S.G.
; Ale-Rocha, Rosaly
; Rocha, Rosana M. da
; Tidon, Rosana
; Brito, Rosangela
; Pellens, Roseli
; Santos, Sabrina R. dos
; Santos, Sandra D. dos
; Paiva, Sandra V.
; Santos, Sandro
; Oliveira, Sarah S. de
; Costa, Sávio C.
; Gardner, Scott L.
; Leal, Sebastián A. Muñoz
; Aloquio, Sergio
; Bonecker, Sergio L.C.
; Bueno, Sergio L. de S.
; Almeida, Sérgio M. de
; Stampar, Sérgio N.
; Andena, Sérgio R.
; Posso, Sergio R.
; Lima, Sheila P.
; Gadelha, Sian de S.
; Thiengo, Silvana C.
; Cohen, Simone C.
; Brandão, Simone N.
; Rosa, Simone P.
; Ribeiro, Síria L.B.
; Letana, Sócrates D.
; Santos, Sonia B. dos
; Andrade, Sonia C.S.
; Dávila, Stephane
; Vaz, Stéphanie
; Peck, Stewart B.
; Christo, Susete W.
; Cunha, Suzan B.Z.
; Gomes, Suzete R.
; Duarte, Tácio
; Madeira-Ott, Taís
; Marques, Taísa
; Roell, Talita
; Lima, Tarcilla C. de
; Sepulveda, Tatiana A.
; Maria, Tatiana F.
; Ruschel, Tatiana P.
; Rodrigues, Thaiana
; Marinho, Thais A.
; Almeida, Thaís M. de
; Miranda, Thaís P.
; Freitas, Thales R.O.
; Pereira, Thalles P.L.
; Zacca, Thamara
; Pacheco, Thaynara L.
; Martins, Thiago F.
; Alvarenga, Thiago M.
; Carvalho, Thiago R. de
; Polizei, Thiago T.S.
; McElrath, Thomas C.
; Henry, Thomas
; Pikart, Tiago G.
; Porto, Tiago J.
; Krolow, Tiago K.
; Carvalho, Tiago P.
; Lotufo, Tito M. da C.
; Caramaschi, Ulisses
; Pinheiro, Ulisses dos S.
; Pardiñas, Ulyses F.J.
; Maia, Valéria C.
; Tavares, Valeria
; Costa, Valmir A.
; Amaral, Vanessa S. do
; Silva, Vera C.
; Wolff, Vera R. dos S.
; Slobodian, Verônica
; Silva, Vinícius B. da
; Espíndola, Vinicius C.
; Costa-Silva, Vinicius da
; Bertaco, Vinicius de A.
; Padula, Vinícius
; Ferreira, Vinicius S.
; Silva, Vitor C.P. da
; Piacentini, Vítor de Q.
; Sandoval-Gómez, Vivian E.
; Trevine, Vivian
; Sousa, Viviane R.
; Sant’Anna, Vivianne B. de
; Mathis, Wayne N.
; Souza, Wesley de O.
; Colombo, Wesley D.
; Tomaszewska, Wioletta
; Wosiacki, Wolmar B.
; Ovando, Ximena M.C.
; Leite, Yuri L.R.
.
ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7
7.
Brazilian Psychiatric Association guidelines on the integration of spirituality into mental health clinical practice: Part 1. Spiritual history and differential diagnosis practice 1
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Mosqueiro, Bruno Paz
; Costa, Marianna de Abreu
; Caribé, André C.
; Oliveira e Oliveira, Fabrício H.A.
; Pizutti, Leandro
; Zimpel, Rogério R.
; Baldaçara, Leonardo
; da Silva, Antônio Geraldo
; Moreira-Almeida, Alexander
.
Objectives: To present evidence-based guidelines for clinical practice regarding religiosity and spirituality in mental health care in Brazil. Methods: A systematic review was conducted to identify potentially eligible articles indexed in the PubMed, PsycINFO, SciELO, LILACS, and Cochrane databases. A summary of recommendations and their levels of evidence was produced in accordance with Oxford Centre for Evidence-Based Medicine guidelines. Results: The systematic review identified 6,609 articles, 41 of which satisfied all inclusion criteria. Taking a spiritual history was found to be an essential part of a compassionate and culturally sensitive approach to care. It represents a way of obtaining relevant information about the patient’s religiosity/spirituality, potential conflicts that could impact treatment adherence, and improve patient satisfaction. Consistent evidence shows that reported perceptual experiences are unreliable for differentiating between anomalous experiences and psychopathology. Negative symptoms, cognitive and behavioral disorganization, and functional impairment are more helpful for distinguishing pathological and non-pathological anomalous experiences. Conclusion: Considering the importance of religiosity/spirituality for many patients, a spiritual history should be routinely included in mental health care. Anomalous experiences are highly prevalent, requiring a sensitive and evidence-based approach to differential diagnosis. Objectives evidencebased based Brazil Methods PubMed PsycINFO SciELO LILACS databases EvidenceBased Evidence Based Results 6609 6 609 6,60 4 criteria patients s religiosityspirituality adherence satisfaction psychopathology symptoms disorganization nonpathological non Conclusion prevalent diagnosis 660 60 6,6 66 6,
8.
Long-term oncological and surgical outcomes after Video Endoscopic Inguinal Lymphadenectomy (VEIL) in patients with penile cancer Longterm Long term VEIL (VEIL
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Tobias-Machado, Marcos
; Ornellas, Antonio A.
; Hidaka, Alexandre K.
; Medina, Luis G.
; Mattos, Pablo A. L.
; Besio, Ruben S.
; Abreu, Diego
; Castro, Pedro R.
; Nishimoto, Ricardo H.
; Astigueta, Juan
; Dourado, Aurus
; Machado, Roberto D.
; Magnabosco, Wesley J.
; Corona-Montes, Victor
; Villoldo, Gustavo M.
; Zampolli, Hamilton C.
; Taha, Anis
; Auad, Pericles R.
; Faria, Eliney F.
; Arantes, Paulo B. O.
; Tavares, Alessandro
; Nascimento, Francisco S. M. S.
; Brazão Jr., Eder S.
; Rocha, Maurício M.
; Costa, Walter H.
; Panico, Vinicius
; Reis, Leonardo O.
; Almeida-Carrera, Roberto J.
; Silva, Rafael C.
; Zequi, Stênio C.
; Calixto, José R. R.
; Sotelo, Rene
.
ABSTRACT Objective: To report outcomes from the largest multicenter series of penile cancer patients undergoing video endoscopic inguinal lymphadenectomy (VEIL). Materials and Methods: Retrospective multicenter analysis. Authors of 21 centers from the Penile Cancer Collaborative Coalition-Latin America (PeC-LA) were included. All centers performed the procedure following the same previously described standardized technique. Inclusion criteria included penile cancer patients with no palpable lymph nodes and intermediate/high-risk disease and those with non-fixed palpable lymph nodes less than 4 cm in diameter. Categorical variables are shown as percentages and frequencies whereas continuous variables as mean and range. Results: From 2006 to 2020, 210 VEIL procedures were performed in 105 patients. Mean age was 58 (45-68) years old. Mean operative time was 90 minutes (60-120). Mean lymph node yield was 10 nodes (6-16). Complication rate was 15.7%, including severe complications in 1.9% of procedures. Lymphatic and skin complications were noted in 8.6 and 4.8% of patients, respectively. Histopathological analysis revealed lymph node involvement in 26.7% of patients with non-palpable nodes. Inguinal recurrence was observed in 2.8% of patients. 10y- overall survival was 74.2% and 10-y cancer specific survival was 84.8%. CSS for pN0, pN1, pN2 and pN3 were 100%, 82.4%, 72.7% and 9.1%, respectively. Conclusion: VEIL seems to offer appropriate long term oncological control with minimal morbidity. In the absence of non-invasive stratification measures such as dynamic sentinel node biopsy, VEIL emerged as the alternative for the management of non-bulky lymph nodes in penile cancer. Objective VEIL. . (VEIL) Methods 2 CoalitionLatin Coalition Latin PeCLA PeC LA (PeC-LA technique intermediate/highrisk intermediatehighrisk intermediate/high risk intermediate high nonfixed non fixed diameter range Results 200 2020 5 4568 45 68 (45-68 old 9 60120. 60120 60 120 (60-120) 1 616. 616 6 16 (6-16) 157 15 7 15.7% 19 1.9 86 8 8. 48 4.8 respectively 267 26 26.7 nonpalpable 28 2.8 10y y 742 74 74.2 848 84 84.8% pN0 pN pN1 100 100% 824 82 82.4% 727 72 72.7 91 9.1% Conclusion morbidity noninvasive invasive biopsy nonbulky bulky (VEIL highrisk intermediatehigh 20 202 456 (45-6 6012 12 (60-120 61 (6-16 15.7 1. 4. 26. 2. 74. 84.8 82.4 72. 9.1 (45- 601 (60-12 (6-1 15. 84. 82. 9. (45 (60-1 (6- (4 (60- (6 ( (60
9.
Gas exchange and photochemical efficiency of guava under saline water irrigation and nitrogen-potassium fertilization nitrogenpotassium nitrogen potassium
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Nobre, Reginaldo G.
; Rodrigues Filho, Ricardo A.
; Lima, Geovani S. de
; Linhares, Edna L. da R.
; Soares, Lauriane A. dos A.
; Silva, Luderlândio de A.
; Teixeira, Antônio D. da S.
; Macumbi, Nelson J. V.
.
Revista Brasileira de Engenharia Agrícola e Ambiental
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RESUMO Objetivou-se com o presente estudo avaliar os efeitos de diferentes combinações de adubação nitrogenada e potássica sobre as trocas gasosas e fluorescência da clorofila a em mudas de goiabeira cv. Paluma irrigadas com águas de distintas salinidades. O experimento foi instalado em delineamento em blocos casualizados e analisados no esquema fatorial 5 × 4, com quatro repetições. Os tratamentos foram compostos a partir da combinação do fator condutividade elétrica da água de irrigação - CEa (0,3; 1,1; 1,9; 2,7 e 3,5 dS m-1) com o fator combinações (C) formada a partir de doses recomendadas de nitrogênio (N) e potássio (K2O): 70% N + 50% K2O; 100% N + 75% K2O; 130% N + 100% K2O e 160% N + 125% K2O. A combinação de adubação 130% N + 100% K2O mitigou o estresse salino até a CEa média de 1,3 dS m-1, resultando em aumento na taxa de assimilação de CO2, transpiração, eficiência instantânea de carboxilação e taxa de transporte de elétrons. Para a máxima eficiência quântica do fotossistema II, apenas os tratamentos irrigados com CEa 3,5 dS m-1 e combinação 160% N + 125% K2O apresentaram danos no aparelho fotossintético. Objetivouse Objetivou se cv salinidades 4 repetições 0,3 03 0 3 (0,3 1,1 11 1 1,9 19 9 27 2 7 2, 35 3, m1 m C (C (N KO K (K2O) 70 50 100 75 130 160 125 13 1, m1, CO2 CO transpiração elétrons II m- fotossintético 0, (0, (K2O 10 16 12 (0 (
ABSTRACT The objective of this study was to evaluate the effects of different combinations of nitrogen and potassium fertilization on gas exchange and chlorophyll a fluorescence in seedlings of guava cv. Paluma irrigated with water of different salinity levels. The experiment was set up in a randomized block design and analyzed in 5 × 4 factorial scheme, with four replicates. The treatments were composed of the combination of the factor electrical conductivity of irrigation water - ECw (0.3, 1.1, 1.9, 2.7, and 3.5 dS m-1), with the factor combinations (C) formed from recommended doses of nitrogen (N) and potassium (K2O), 70% N + 50% K2O, 100% N + 75% K2O, 130% N + 100% K2O, and 160% N + 125% K2O. The fertilization combination 130% N + 100% K2O mitigated the effects of salt stress up to mean ECw of 1.3 dS m-1, resulting in increments in CO2 assimilation rate, transpiration, instantaneous carboxylation efficiency, and electron transport rate. For maximum quantum efficiency of photosystem II, only treatment irrigated with ECw 3.5 dS m-1 under the combination 160% N + 125% K2O showed damage to the photosynthetic apparatus. cv levels scheme replicates 0.3, 03 0 3 (0.3 11 1 1.1 19 9 1.9 27 2 7 2.7 35 3. m1, m1 m , m-1) C (C (N KO K O (K2O) 70 50 100 75 130 160 125 13 1. 1, CO rate transpiration II m- apparatus 0.3 (0. 2. (K2O 10 16 12 0. (0 (
10.
Children with malignancies and septic shock - an attempt to understand the risk factors
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Abstract Objectives: To explain the high mortality of septic shock in children with cancer. Methods: A retrospective cohort from 2016 to 2020, of children aged 0 to 18 years, and septic shock. Results: The authors included 139 patients. Acute lymphocytic leukemia was the most frequent diagnosis (16.5%), and Gram-negative bacteria were the most frequent blood culture isolates (22.3%). There were 57 deaths in ICU (41%), 10 in the first 24 hours of shock (early death). A LASSO model with variables: neutropenia (coefficient 0.215), respiratory (0.81), hematological (1.41), and neurological (0.72) dysfunctions, age (-0.002) and solid tumor recurrence (0.34) generated AUC = 0.79 for the early death outcome. Survivors had significant differences in the PRISM-IV score (mean ± SD 10.9 ± 6.2 in the survivors, 14.1 ± 6.5 in the deceased, p = 0.004), and in the mean number of organ dysfunctions (3.2 ± 1.1 in the survivors, 3.8 ± 6.5 in the deceased, p < 0.001). A positive fluid balance in the first 24 hours of sepsis between 2% and 6% of body weight showed a reduction effect on the probability of death in ICU (hazard ratio 0.47, 95% CI 0.24–0.92, p = 0.027). The recurrence of any cancer was a predictor of in-hospital death, regardless of severity. Conclusions: Recurrence of any cancer is an important risk of sepsis-related death. A positive fluid balance between 20 and 60 mL/kg or 2% and 6% of body weight in the first 24 hours after the onset of sepsis is related to lower mortality. Objectives Methods 201 2020 1 years Results 13 patients 16.5%, 165 16.5% , 16 5 (16.5%) Gramnegative Gram negative 22.3%. 223 22.3% . 22 3 (22.3%) 41%, 41 41% (41%) 2 death) variables coefficient 0.215, 0215 0.215 215 0.215) 0.81, 081 0.81 81 (0.81) 1.41, 141 1.41 (1.41) 0.72 072 72 (0.72 0.002 0002 002 (-0.002 0.34 034 34 (0.34 079 79 0.7 outcome PRISMIV PRISM IV 109 9 10. 62 6 6. survivors 14 14. 65 deceased 0.004, 0004 0.004 004 0.004) 3.2 32 (3. 11 1. 38 8 3. 0.001. 0001 0.001 001 0.001) hazard 047 47 0.47 95 024092 92 0.24–0.92 0.027. 0027 0.027 027 0.027) inhospital hospital severity Conclusions sepsisrelated mLkg mL kg 202 16.5 (16.5% 22.3 (22.3% 4 (41% 021 0.21 21 08 0.8 (0.81 1.4 (1.41 07 7 (0.7 0.00 000 00 (-0.00 0.3 03 (0.3 0. (3 04 0.4 02409 0.24–0.9 0.02 02 16. (16.5 22. (22.3 (41 0.2 (0.8 (1.4 (0. 0.0 (-0.0 ( 0240 0.24–0. (16. (22. (4 (1. (0 (-0. 024 0.24–0 (16 (22 (1 (-0 0.24– (2 (- 0.24
11.
Enhanced Larvicidal Activity of New 1,2,4-Oxadiazoles against Aedes aegypti Mosquitos: QSAR and Docking Studies 1,2,4Oxadiazoles 124Oxadiazoles Oxadiazoles 1,2,4 1 2 4 Mosquitos 4Oxadiazoles 124 1,2, 12 1,2 1,
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Silva, Aluízio G. da
; Navarro, Daniela Maria A. F.
; Santos, Geanne K. N.
; Aguiar, Júlio César R. O. F. de
; França, Karla A. de
; Tébéka, Iris Raquel M.
; Anjos, Janaína V. dos
; Silva, João Bosco P. da
; Kanis, Luiz A.
; Srivastava, Rajendra M.
; Neves Filho, Ricardo Antônio W.
; Ramos, Mozart N.
.
The worldwide emergence of viral diseases such as Zika, Dengue, Chikungunya, West Nile and Yellow Fever urge the search for solutions to eliminate their common vector, the Aedes aegypti mosquito. This paper describes the quantitative structure-activity relationship (QSAR) and docking studies of a series of nine 3-(3-aryl-1,2,4-oxadiazol-5-yl)propionic acids (AOPA), 1-9, previously published by our group. Additionally, three new 1,2,4-oxadiazoles, 10-12, have also been synthesized, characterized and studied. The QSAR and docking studies of all compounds, 1-12, clearly indicate that larger hydrophobic substituents such as biphenyl groups attached on position 3 in 1,2,4-oxadiazoles improve the larvicidal activity. It is worthwhile to mention that nanocapsulation of compounds 10-12 were necessary to help their dissolution in water and these three new 1,2,4-oxadiazoles also exhibited approximately equal or higher larvicidal activities compared to the former prototypes at stage L4. Zika Dengue Chikungunya vector mosquito structureactivity structure activity (QSAR 33aryl1,2,4oxadiazol5ylpropionic 33aryl124oxadiazol5ylpropionic aryloxadiazolylpropionic aryl 1,2,4 oxadiazol 5 yl propionic 1 2 4 AOPA, AOPA , (AOPA) 19, 19 9, 9 1-9 group Additionally 1,2,4oxadiazoles, 124oxadiazoles oxadiazoles oxadiazoles, 1012, 1012 10 12, 12 synthesized studied 112, 112 1-12 1,2,4oxadiazoles 10-1 L4 L 33aryl1 4oxadiazol5ylpropionic ylpropionic 124 1,2, (AOPA 1- 4oxadiazoles 101 11 1-1 10- 33aryl oxadiazolylpropionic 1,2 1,
12.
Low-Temperature Partitioning: A Simple Screening Method for Determining Diethylene Glycol in Beer by Gas Chromatography LowTemperature Low Temperature Partitioning
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Azevedo, Mariane M.
; Miranda, Liany D. L.
; Queiroz, Maria Eliana L. R. de
; Oliveira, André F. de
; Pereira, Alexandre F.
; Neves, Antônio A.
; Silva, Thaís L. R.
.
Diethylene glycol is an extremely toxic substance to humans. Recently, cases of beer contamination in Brazil have raised awareness of the need for developing simple screening methods to evaluate this type of compound. This research developed a liquid-liquid extraction with low-temperature partitioning technique to determine diethylene glycol in beer via gas chromatography. Employing a flame-ionization detector simplifies the method, lowers its cost and therefore, it can be used as screening step to assess the possibility of contamination. A gas chromatograph coupled to a mass spectrometer would be used only for a confirmatory analysis. The optimized method was validated for the main figures of merit, and it proved to be adequate, with good values of recovery rate (94-106%), limit of detection (3.0 mg L-1), and quantification (10.0 mg L-1). Accuracy, in terms of repeatability and intermediate accuracy, showed variation coefficients lower than or equal to 20%. This method was applied to 28 samples of beers marketed in Brazil, and diethylene glycol was found above the limit of detection in three of them (10.7%). These results were confirmed by a gas chromatograph coupled to a mass spectrometer, which showed the reliability of the screening method for determining diethylene glycol in beer samples. humans Recently compound liquidliquid liquid lowtemperature low temperature chromatography flameionization flame ionization therefore analysis merit adequate 94106%, 94106 94 106% , 106 (94-106%) 3.0 30 3 0 (3. L1, L1 L 1 L-1) 10.0 100 10 (10. L1. . Accuracy accuracy 20 20% 2 10.7%. 107 10.7% 7 (10.7%) 94106% 9410 9 (94-106% 3. (3 L-1 10. (10 10.7 (10.7% 941 (94-106 ( L- (1 (10.7 (94-10 (94-1 (94- (94 (9
13.
Brazilian Psychiatric Association guidelines for the management of suicidal behavior. Part 3. Suicide prevention hotlines behavior 3
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Baldaçara, Leonardo
; Weber, César Augusto Trinta
; Gorender, Miriam
; Grudtner, Roberta R.
; Peu, Sandra
; Teles, Ana Luiza Silva
; Cavalcante, Ives Passos
; Quevedo, João
; da Silva, Antônio Geraldo
.
Crisis hotlines are direct communication systems, usually telephone-based, set up to prevent suicide. However, few studies have evaluated their effectiveness. The present study aims to perform a systematic review, using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework, of the effectiveness of interventions through direct communication systems to reduce the number of suicides or suicide attempts. We searched the MEDLINE, Cochrane, SciELO, and ClinicaTrials.gov databases, and used the 2011 Oxford Centre for Evidence-Based Medicine Levels of Evidence classification. The literature search yielded 267 studies, of which 35 fulfilled the selection criteria. Although significant heterogeneity was found among studies, there is evidence that direct telephone interventions are effective when included in broader preventive protocols and provided by trained staff. Despite the limitations, which included heterogeneity of samples, designs, and outcome measures, we were able to design a protocol for the use of remote services to prevent suicide and suicide attempts. A hotline or similar system could be an effective intervention for broader suicide prevention programs. However, further research is necessary to specify which protocol components are key to enhance effectiveness. Systematic review registry number: PROSPERO CRD42020206517 telephonebased, telephonebased based, based telephone-based However MetaAnalyses Meta Analyses PRISMA (PRISMA framework attempts MEDLINE Cochrane SciELO ClinicaTrialsgov ClinicaTrials gov databases 201 EvidenceBased Based classification 26 3 criteria staff limitations samples designs measures programs CRD CRD4202020651 20 2 CRD420202065 CRD42020206 CRD4202020 CRD420202 CRD42020 CRD4202 CRD420 CRD42 CRD4
14.
Effect of Friction Stir Welding on Microstructure and Mechanical Properties of uns C19400 Alloy Plates C C1940 C194 C19 C1
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Martins, Floriano
; Varasquim, Francisco M.F.A.
; Cruz Junior, Eli J.
; Nakamoto, Francisco Y.
; Santos, Vinicius T.
; Vatavuk, Jan
; Silva, Márcio R.
; Couto, Antonio A.
; Santos, Givanildo A.
.
The welding of metallic materials by the Friction Stir Welding (FSW) method is a very attractive process for preserving their characteristics, especially for copper and its alloys that require high heat input and present many distortions by traditional methods. However, it is a great challenge to produce welds free of defects and maintain or improve their mechanical properties. In the current literature data on FSW parameters for copper and its alloys are scarce. In this study, tests were performed with a combination of four tool rotations (750, 850, 950, 1050 rev.min-1) and two welding speeds (20 and 60 mm.min-1), maintaining the tool inclination angle in 3° and waiting time of 5 seconds. The objective of this work is to analyze the microstructure and mechanical performance of lap joints of the UNS C19400 alloy joined by FSW. The process temperature was monitored to trace the heating profile of the process, in addition to microhardness and shear strength tests, in addition to optical microscopy for analysis. The joints welded by the parameters Ω 950 rev.mm-1 �� 20mm.min-1 obtained a mechanical performance of 73% compared to the characteristics of the base metal and despite the appearance of volumetric defects at the microstructural level, the metallurgical transformations of recovery and recrystallization of the grains observed in the microstructure played a key role in the result. (FSW methods However properties scarce study 750, 750 (750 850 105 rev.min1 revmin1 revmin rev.min 1 rev min rev.min-1 20 (2 6 mm.min1, mmmin1 mmmin mm.min , mm mm.min-1) 3 seconds C C1940 analysis 95 rev.mm1 revmm1 revmm rev.mm rev.mm- � 20mm.min1 20mmmin1 20mm.min 20mm 20mm.min- 73 level result 75 (75 85 10 min1 rev.min- 2 ( mm.min1 mm.min-1 C194 9 mm1 20mmmin 7 (7 8 mm.min- C19 C1
15.
The Challenges of Implementing a Text Message Intervention to Promote Behavioral Change in Primary Care Patients With Hypertension and Diabetes
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Oliveira, João Antonio de Queiroz
; Cimini, Christiane
; Almeida, Vania
; Maia, Junia Xavier
; Resende, Raissa Eda
; Gualberto, Leticia Alves
; Santos, Pedro Henrique Lauar
; Gomes, Paulo R.
; Bonisson, Leonardo
; Paixão, Maria Cristina
; Costa, Janaina Moutinho
; Cardoso, Clareci Silva
; Santo, Karla
; Ribeiro, Antonio
; Martins, Maria Auxiliadora
; Marcolino, Milena S.
.
International Journal of Cardiovascular Sciences
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Abstract Background Controlling blood pressure and glycemic levels is a challenge that requires innovative solutions. Objective To assess the feasibility of implementing a text message intervention among low-income primary care patients, as well as to assess self-reported behavioral change. Methods A set of 200 text messages was developed on healthy eating, physical activity, adherence, and motivation. Participants from Vale do Mucuri, MG, Brazil diagnosed with diabetes or hypertension or undergoing screening for those diseases, received 5 to 8 messages per week for 6 months. They answered a questionnaire to report their satisfaction and behavioral changes. Results Of the 136 patients, 117 (86.0%) answered the questionnaire. Most reported that the messages were very useful (86.3%), easy to understand (90.6%), and were very helpful for behavioral change (65.0%); 84.6% reported that they had started eating healthier. The most frequent reported lifestyle changes were: improved diet quality (85.5%), reduced portions (65.8%), and weight loss (56.4%). The majority of patients shared the messages (60.7%) with family or other acquaintances, considered the number of messages to be adequate (89.7%) and would recommend the program to others (95.7%). Conclusion An intervention based on text messages to promote behavioral change in patients with hypertension or diabetes in primary care is feasible in low-resource settings. Future studies are needed to assess the program’s long-term effects on clinical outcomes. solutions lowincome low income selfreported self 20 activity adherence motivation Mucuri MG diseases months 13 11 86.0% 860 86 0 (86.0% 86.3%, 863 86.3% , 3 (86.3%) 90.6%, 906 90.6% 90 (90.6%) 65.0% 650 65 (65.0%) 846 84 84.6 healthier 85.5%, 855 85.5% 85 (85.5%) 65.8%, 658 65.8% (65.8%) 56.4%. 564 56.4% . 56 4 (56.4%) 60.7% 607 60 7 (60.7% acquaintances 89.7% 897 89 (89.7% 95.7%. 957 95.7% 95 (95.7%) lowresource resource settings programs s longterm long term outcomes 2 1 86.0 (86.0 86.3 (86.3% 90.6 9 (90.6% 65.0 (65.0% 84. 85.5 (85.5% 65.8 (65.8% 56.4 (56.4% 60.7 (60.7 89.7 (89.7 95.7 (95.7% 86. (86. (86.3 90. (90.6 65. (65.0 85. (85.5 (65.8 56. (56.4 60. (60. 89. (89. 95. (95.7 (86 (90. (65. (85. (56. (60 (89 (95. (8 (90 (65 (85 (56 (6 (95 ( (9 (5
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