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ABSTRACT Despite being subject to lower AIDS-related mortality rates and having a higher life expectancy, patients with HIV are more prone to develop non-AIDS events. A low CD4+/CD8+ ratio during antiretroviral therapy identifies people with heightened immune senescence and increased risk of mortality. In clinical practice, finding determinants of a low CD4+/CD8+ ratio may be useful for identifying patients who require close monitoring due to an increased risk of comorbidities and death. We performed a prospective study on the evolution of the CD4+/CD8+ ratio in 60 patients infected with HIV (80% males), who were subjected to two different antiretroviral regimens: early and deferred therapy. The initial CD4+/CD8+ ratio was ≤1 for 70% of the patients in both groups. Older age, CD4+ cell count at inclusion, Nadir CD8+T-cell count, and Initial CD4+/CD8+ ratio ≤ 1 were risk factors for lack of ratio recovery. In the multivariate analysis, a CD4+/CD8+ ratio > 1 at the start of the treatment was found to be a determinant factor in maintaining a CD4+/CD8+ ratio > 1. The nadir CD4+T-cell count was lower in the deferred therapy group (p=0.004), and the last CD4+/CD8+ ratio ≤1 was not associated with comorbidities. Ratio recovery was not associated with the duration of HIV infection, time without therapy, or absence of AIDS incidence. A greater improvement was observed in patients treated early (p=0.003). In contrast, the slope of increase was slower in patients who deferred treatment. In conclusion, the increase in the CD4+/CD8+ ratio occurred mostly for patients undergoing early strategy treatment and its extension did not seem to be related to previous HIV-related factors. AIDSrelated expectancy nonAIDS non events CD4CD8 CDCD CD4 CD8 CD CD4+/CD8 practice death 6 80% 80 (80 males, males , males) regimens 70 groups age inclusion CD8+Tcell CD8Tcell CDTcell CD8+T T analysis CD4+Tcell CD4Tcell CD4+T p=0.004, p0004 p p=0.004 0 004 (p=0.004) infection incidence p=0.003. p0003 p=0.003 . 003 (p=0.003) contrast conclusion HIVrelated CD4CD CD4+/CD 8 (8 7 Tcell CD8T CDT CD4T p000 p=0.00 00 (p=0.004 (p=0.003 ( p00 p=0.0 (p=0.00 p0 p=0. (p=0.0 p=0 (p=0. p= (p=0 (p= (p

https://doi.org/10.1590/s1678-9946202466007

Vaccination coverage, barriers and vaccine hesitancy in children up to 24 months old: a population survey in a state capital in the Western Amazon
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Macedo, Thaiane Rodrigues de Oliveira

; Borges, Maria Fernanda de Sousa Oliveira

; Silva, Ilce Ferreira da

; França, Ana Paula

; Moraes, José Cássio de

; Silva, Adriana Ilha da

; Ramos Jr., Alberto Novaes

; França, Ana Paula

; Oliveira, Andrea de Nazaré Marvão

; Boing, Antonio Fernando

; Domingues, Carla Magda Allan Santos

; Oliveira, Consuelo Silva de

; Maciel, Ethel Leonor Noia

; Guibu, Ione Aquemi

; Mirabal, Isabelle Ribeiro Barbosa

; Barbosa, Jaqueline Caracas

; Lima, Jaqueline Costa

; Moraes, José Cássio de

; Luhm, Karin Regina

; Caetano, Karlla Antonieta Amorim

; Lima, Luisa Helena de Oliveira

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria da Gloria

; Teixeira, Maria Denise de Castro

; Borges, Maria Fernanda de Sousa Oliveira

; Queiroz, Rejane Christine de Sousa

; Gurgel, Ricardo Queiroz

; Barata, Rita Barradas

; Azevedo, Roberta Nogueira Calandrini de

; Oliveira, Sandra Maria do Valle Leone de

; Teles, Sheila Araújo

; Gama, Silvana Granado Nogueira da

; Mengue, Sotero Serrate

; Simões, Taynãna César

; Nascimento, Valdir

; Araújo, Wildo Navegantes de

Epidemiologia e Serviços de Saúde

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2024, Volume 33 N. spe2 elocation e20231295

Abstract: En Pt Es | Text: En Pt Es | PDF: En | PDF: Pt | PDF: Es

resumen está disponible en el texto completo

https://doi.org/10.1590/s2237-96222024v33e20231295.especial2.en

Multimorbidade em idosos e seus fatores associados em 2010 e 2021 201 202 20 2
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Bortoluzzi, Emanuelly Casal

; Mascarelo, Andreia

; Portella, Marilene Rodrigues

; Silva, Shana Ginar da

; Alves, Ana Luisa Sant’Anna

Revista Brasileira de Geriatria e Gerontologia

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2024, Volume 27 elocation e230231

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O presente estudo teve como objetivo comparar os fatores associados à multimorbidade em idosos de 60 a 69 anos, em 2010 e 2021. Trata-se de um estudo transversal comparativo, composto por dois estudos transversais. Ambas as coletas de dados foram realizadas de forma individual por entrevistadores treinados e deu-se por inquérito domiciliar, no município de Coxilha-RS, Brasil. Utilizou-se para análise inferencial bivariada, exato de Fisher e qui-quadrado, e multivariada o teste de regressão de Poisson com variância robusta com nível de significância de p 0,05. Detectou-se que a prevalência de multimorbidade teve uma diminuição significativa, passando de 66,5% em 2010, para 41,6% em 2021. Ser dependente para atividades básicas e instrumentais da vida diária associou-se a maior prevalência para a multimorbidade no ano de 2010, contudo no ano de 2021 o ser dependente para atividades instrumentais, não saber ler/escrever e não trabalhar apresentou maior prevalência para a multimorbidade. Por fim, concluise que as condições de saúde dos idosos diferiram significativamente apontando que os cuidados de saúde também precisam ser reavaliados para tornarem-se mais efetivos 6 anos 201 Tratase Trata se comparativo transversais deuse deu domiciliar CoxilhaRS, CoxilhaRS Coxilha RS, RS Coxilha-RS Brasil Utilizouse Utilizou bivariada quiquadrado, quiquadrado qui quadrado, quadrado qui-quadrado 005 0 05 0,05 Detectouse Detectou significativa 665 66 5 66,5 416 41 41,6 associouse associou 202 lerescrever ler escrever fim tornaremse tornarem 20 00 0,0 66, 4 41, 2 0,

Abstract The present study aimed to compare the factors associated with multimorbidity in older adults aged 60 to 69 years, in 2010 and 2021. This is a comparative cross-sectional study, comprised of other two cross-sectional studies. Both data collections were individually conducted by trained interviewers through household surveys in the municipality of Coxilha-RS, Brazil. Bivariate inferential analysis was conducted using Fisher's exact test and chi-square test, while multivariate analysis employed Poisson regression with robust variance with a significance level of p 0.05. It was observed that the prevalence of multimorbidity significantly decreased, decreasing from 66.5% in 2010 to 41.6% in 2021. Dependency for basic and instrumental activities of daily living was associated with higher prevalence of multimorbidity in the year 2010. However, in 2021, being dependent on instrumental activities, being unable to read/write, and being unemployed showed higher prevalence for multimorbidity. In conclusion, it is evident that the health conditions of older adults differed significantly over the years, highlighting the necessity for a reevaluation of healthcare practices to become more effective 6 years 201 2021 crosssectional cross sectional studies CoxilhaRS, CoxilhaRS Coxilha RS, RS Coxilha-RS Brazil Fishers Fisher s chisquare chi square 005 0 05 0.05 decreased 665 66 5 66.5 416 41 41.6 However readwrite read write read/write conclusion 20 202 00 0.0 66. 4 41. 2 0.

https://doi.org/10.1590/1981-22562024027.230231.pt

New insights into the use of dwarf tomato plants for pest resistance
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Maciel, Gabriel Mascarenhas

; Oliveira, Camila Soares de

; Siquieroli, Ana Carolina Silva

; Pereira, Lucas Medeiros

; Ribeiro, Ana Luisa Alves

; Pinto, Frederico Garcia

; Ikehara, Brena Rodrigues Mota

; Silva, Nilo Cesar Queiroga

; Farias, Ana Karoline Silva Rocha de

Bragantia

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2024, Volume 83 elocation e20240066

Abstract: En | Text: En | PDF: En

ABSTRACT Tomato (Solanum lycopersicum L.), a globally significant species, faces substantial economic losses due to pest insects. However, exploiting dwarf germplasm for pest resistance, particularly the UFU MC TOM1 lineage, remains underexplored. The objectives of this study were to select backcross populations from dwarf tomato plants through direct and indirect selection and to elucidate whether there are consequences in resistance level as backcross generations progress aiming at a genetic background of interest. Backcross populations 1, 2, and 3 of dwarf tomato plants were obtained. In the conducted experiment, featuring 20 treatments and four repetitions in a randomized block design, we assessed foliar injuries and herbivory through image analysis. Additionally, we quantified the content of acylsugars, conducted chromatographic analysis, and analyzed the metabolomic profile in the leaflets. Promisingly, the UFU 13_1 dwarf plant population showed potential for enhancing genetic improvement programs targeting pest insect resistance. Moreover, the progression of backcross generations yielded varied resistance levels, likely influenced by inheritance patterns and acylsugar content. The UFU MC TOM1 line, distinguished by its high acylsugar content, exhibited robust resistance against both the tomato leafminer (Tuta absoluta Meyrick 1917) and the leafminer (Liriomyza huidobrensis Blanchard). Furthermore, our analysis revealed the expression of metabolites in the UFU MC TOM1 lineage, potentially linked to various biotic and abiotic stress responses. These findings offer promising prospects for leveraging the dwarf tomato variety, UFU MC TOM1, in genetic improvement programs aimed at combating pest insects in tomatoes. Solanum L., L L. , L.) species However TOM lineage underexplored interest 1 2 obtained experiment design Additionally acylsugars leaflets Promisingly 131 13 13_ Moreover levels line Tuta 1917 Liriomyza Blanchard. Blanchard . Blanchard) Furthermore responses variety tomatoes 191 19

https://doi.org/10.1590/1678-4499.20240066

Vaccination coverage, barriers and vaccine hesitancy in children up to 24 months old: a population survey in a state capital in the Western Amazon coverage 2 old
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Macedo, Thaiane Rodrigues de Oliveira

; Borges, Maria Fernanda de Sousa Oliveira

; Silva, Ilce Ferreira da

; França, Ana Paula

; Moraes, José Cássio de

; Silva, Adriana Ilha da

; Ramos Jr., Alberto Novaes

; França, Ana Paula

; Oliveira, Andrea de Nazaré Marvão

; Boing, Antonio Fernando

; Domingues, Carla Magda Allan Santos

; Oliveira, Consuelo Silva de

; Maciel, Ethel Leonor Noia

; Guibu, Ione Aquemi

; Mirabal, Isabelle Ribeiro Barbosa

; Barbosa, Jaqueline Caracas

; Lima, Jaqueline Costa

; Moraes, José Cássio de

; Luhm, Karin Regina

; Caetano, Karlla Antonieta Amorim

; Lima, Luisa Helena de Oliveira

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria da Gloria

; Teixeira, Maria Denise de Castro

; Borges, Maria Fernanda de Sousa Oliveira

; Queiroz, Rejane Christine de Sousa

; Gurgel, Ricardo Queiroz

; Barata, Rita Barradas

; Azevedo, Roberta Nogueira Calandrini de

; Oliveira, Sandra Maria do Valle Leone de

; Teles, Sheila Araújo

; Gama, Silvana Granado Nogueira da

; Mengue, Sotero Serrate

; Simões, Taynãna César

; Nascimento, Valdir

; Araújo, Wildo Navegantes de

Epidemiologia e Serviços de Saúde

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2024, Volume 33 N. spe2 elocation e20231295

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo Estimar a cobertura vacinal, identificar barreiras e hesitação à vacinação em crianças com até 24 meses, nascidas em 2017 e 2018, residentes na área urbana de Rio Branco-AC. Métodos Inquérito populacional realizado de 2020 a 2021, que avaliou as características sociodemográficas e a situação vacinal em crianças nascidas entre 2017 e 2018. Resultados Entre as 451 crianças estudadas, as coberturas vacinais foram inferiores a 80%. A menor cobertura para doses aplicadas (76,3%; IC95% 70,5;81,3) e oportunas (27,4%; IC95% 23,1;32,1) foi para o reforço da meningocócica C. As afirmações “vacinas causam reações adversas graves” (26,4%; IC95% 18,1;36,8) e “não precisa da vacina para doenças que não existem mais” (22%; IC95% 15,7;29,8) foram as mais frequentes quanto à hesitação vacinal. A falta da vacina foi a principal barreira assistencial (86,6%; IC95% 71,8;94,3). Conclusão As coberturas vacinais em crianças nascidas em 2017 e 2018 ficaram abaixo da meta preconizada nos esquemas completos de doses aplicadas, válidas e oportunas. 2 meses 201 BrancoAC. BrancoAC Branco AC. AC Branco-AC 202 2021 45 estudadas 80 80% 76,3% 763 76 3 (76,3% IC95 IC 70,581,3 705813 70,5 81,3 70 5 81 70,5;81,3 27,4% 274 27 4 (27,4% 23,132,1 231321 23,1 32,1 23 1 32 23,1;32,1 C vacinas graves 26,4% 264 26 (26,4% 18,136,8 181368 18,1 36,8 18 36 8 18,1;36,8 22% 22 (22% 15,729,8 157298 15,7 29,8 15 7 29 15,7;29,8 86,6% 866 86 6 (86,6% 71,894,3. 718943 71,8 94,3 . 71 94 71,8;94,3) 20 76,3 (76,3 IC9 581 70,581, 70581 705 70, 813 81, 70,5;81, 27,4 (27,4 132 23,132, 23132 231 23, 321 32, 23,1;32, 26,4 (26,4 136 18,136, 18136 181 18, 368 36, 18,1;36, (22 729 15,729, 15729 157 15, 298 29, 15,7;29, 86,6 (86,6 894 71,894,3 71894 718 71, 943 94, 9 71,8;94,3 76, (76, 58 70,581 7058 70,5;81 27, (27, 13 23,132 2313 23,1;32 26, (26, 18,136 1813 18,1;36 (2 72 15,729 1572 15,7;29 86, (86, 89 71,894, 7189 71,8;94, (76 70,58 70,5;8 (27 23,13 23,1;3 (26 18,13 18,1;3 ( 15,72 15,7;2 (86 71,894 71,8;94 (7 70,5; 23,1; 18,1; 15,7; (8 71,89 71,8;9 71,8;

ABSTRACT Objective To estimate vaccination coverage, identify barriers and hesitancy to vaccinating children up to 24 months, born between 2017-2018, living in the urban area of Rio Branco, Acre, Brazil. Methods Population survey carried out from 2020 to 2021, which assessed sociodemographic characteristics and vaccination status among children. Results Among 451 included children, vaccination coverage was below 80%. Meningococcal C vaccine had the lowest coverage for administered doses (76.3%; 95%CI 70.5;81.3) and doses on time (27.4%; 95%CI 23.1;32.1). The statements “vaccines cause serious adverse reactions” (26.4%; 95%CI 18.1;36.8) and “you don’t need vaccination for diseases that no longer exist” (22%; 95%CI 15.7;29.8) were the most frequent regarding vaccination hesitancy. Lack of vaccines was the main barrier to care (86.6%; 95%CI 71.8;94.3). Conclusion Vaccination coverage in children born in 2017-2018 was below the target recommended for the full schedule of administered doses, both valid and timely administered. 2 months 20172018, 20172018 2017 2018, 2018 Branco Acre Brazil 202 2021 45 80 80% 76.3% 763 76 3 (76.3% 95CI CI 95 70.581.3 705813 70.5 81.3 70 5 81 70.5;81.3 27.4% 274 27 4 (27.4% 23.132.1. 231321 23.1 32.1 . 23 1 32 23.1;32.1) reactions 26.4% 264 26 (26.4% 18.136.8 181368 18.1 36.8 18 36 8 18.1;36.8 you dont don t exist 22% 22 (22% 15.729.8 157298 15.7 29.8 15 7 29 15.7;29.8 86.6% 866 86 6 (86.6% 71.894.3. 718943 71.8 94.3 71 94 71.8;94.3) 2017-201 2017201 201 20 76.3 (76.3 9 581 70.581. 70581 705 70. 813 81. 70.5;81. 27.4 (27.4 132 23.132.1 23132 231 23. 321 32. 23.1;32.1 26.4 (26.4 136 18.136. 18136 181 18. 368 36. 18.1;36. (22 729 15.729. 15729 157 15. 298 29. 15.7;29. 86.6 (86.6 894 71.894.3 71894 718 71. 943 94. 71.8;94.3 2017-20 201720 76. (76. 58 70.581 7058 70.5;81 27. (27. 13 23.132. 2313 23.1;32. 26. (26. 18.136 1813 18.1;36 (2 72 15.729 1572 15.7;29 86. (86. 89 71.894. 7189 71.8;94. 2017-2 20172 (76 70.58 70.5;8 (27 23.132 23.1;32 (26 18.13 18.1;3 ( 15.72 15.7;2 (86 71.894 71.8;94 2017- (7 70.5; 23.13 23.1;3 18.1; 15.7; (8 71.89 71.8;9 23.1; 71.8;

resumen está disponible en el texto completo

https://doi.org/10.1590/s2237-96222024v33e20231295.especial2.en

Delineamento e Racional do Estudo Rosa dos Ventos: Estudo Multicêntrico do Tipo Coorte de Pacientes com Insuficiência Cardíaca com Fração de Ejeção Reduzida ou Moderadamente Reduzida no Brasil Ventos
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Freitas, Dhayn Cassi de Almeida

; da Costa, Larissa Maria de Paula Rebouças

; Nadruz Jr., Wilson

; Marcondes-Braga, Fabiana G.

; Vieira, Jefferson Luis

; Bernardez-Pereira, Sabrina

; Barbosa Neto, Wilson Rodrigues

; Alves, Silvia Marinho Martins

; Wanderley, Gabriela Arcoverde

; Lira, Camila Nogueira Leandro

; Terui, Lucas Yugi de Souza

; Silva, Ana Luísa Guedes de França e

; Castro, Alana de Oliveira

; Freitas Jr., Aguinaldo F.

; de Figueiredo Neto, José Albuquerque

; Lopes, Renato D.

; Fernandes-Silva, Miguel Morita

; Silvestre, Odilson Marcos

Arquivos Brasileiros de Cardiologia

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2024, Volume 121 N. 10 elocation e20240120

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamento: O Brasil é um país com diferentes biomas e desigualdades sociais. Existem poucos dados disponíveis sobre as diferenças regionais e o prognóstico da insuficiência cardíaca (IC) no país. Objetivo: O estudo Rosa dos Ventos tem como objetivo investigar as diferenças regionais e o prognóstico atual de pacientes com IC com fração de ejeção reduzida ou moderadamente reduzida no Brasil. Métodos: Este é um estudo prospectivo, multicêntrico, observacional, do tipo coorte que incluirá pacientes ambulatoriais com idade superior a 18 anos com IC e fração de ejeção < 50% em 30 centros privados distribuídos nas regiões brasileiras. Um total de 2500 pacientes serão incluídos entre junho de 2021 e outubro de 2023, com um período de 12 meses de seguimento. Coletaremos dados sobre status clínico e socioeconômico, prescrição médica e resultados de exames cardiológicos. Serão realizados telefonemas para o seguimento dos pacientes seis e 12 meses após a inclusão para coleta de informações sobre visitas ao departamento de emergência, internações e mortalidade. Conclusão: O estudo Rosa dos Ventos permitirá uma caracterização mais precisa da IC crônica no Brasil. Essa iniciativa proverá informações relevantes para o desenvolvimento de estratégias de manejo efetivas para mitigar o impacto dessa condição sobre os pacientes e o sistema de saúde. Fundamento sociais (IC Objetivo Métodos prospectivo multicêntrico observacional 1 50 3 brasileiras 250 202 2023 socioeconômico cardiológicos emergência mortalidade Conclusão saúde 5 25 20 2

Abstract Background: Brazil is a country with different biomes and social disparities. There are limited data available on regional differences and prognosis of heart failure (HF) in the country. Objective: The Rosa dos Ventos study aims to investigate regional differences and the current prognosis of HF outpatients with reduced or mildly reduced ejection fraction in Brazil. Methods: This is a prospective, multicenter, observational cohort study that will include outpatients older than 18 years with HF and an ejection fraction < 50% in 30 public and private centers distributed in all Brazilian regions. A total of 2,500 patients will be enrolled from June 2021 and October 2023, with a 12-month follow-up period. We will collect data on socioeconomic and clinical status, medical prescription and results of cardiology tests. Follow-up phone calls will be made at 6 and 12 months after inclusion to collect information regarding emergency room visits, hospitalization and mortality. Conclusion: The Rosa dos Ventos study will allow a more accurate characterization of chronic HF in Brazil. This initiative will provide relevant information for the development of effective management strategies to mitigate the impact of this condition on patients and the healthcare system. Background disparities (HF Objective Methods prospective multicenter 1 50 3 regions 2500 2 500 2,50 202 2023 12month month followup follow up period status tests Followup Follow visits mortality Conclusion system 5 250 2,5 20 25 2,

https://doi.org/10.36660/abc.20240120

Influence of killer immunoglobulin-like receptors genes on the recurrence rate of ocular toxoplasmosis in Brazil immunoglobulinlike immunoglobulin like
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Perce-da-Silva, Daiana de Souza

; Joaquim, Thays Euzebio

; Aleixo, Ana Luisa Quintella do Couto

; Motta, Juliana Pessanha Rodrigues

; Lima-Junior, Josué da Costa

; Ribeiro-Alves, Marcelo

; de Oliveira-Ferreira, Joseli

; Porto, Luís Cristóvão de Moraes Sobrino

; Banic, Dalma Maria

; Amendoeira, Maria Regina Reis

Memórias do Instituto Oswaldo Cruz

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2023, Volume 118 elocation e220203

Abstract: En | Text: En | PDF: En

BACKGROUND Recurrence is a hallmark of ocular toxoplasmosis (OT), and conditions that influence its occurrence remain a challenge. Natural killer cells (NK) are effectors cells whose primary is cytotoxic function against many parasites, including Toxoplasma gondii. Among the NK cell receptors, immunoglobulin-like receptors (KIR) deserve attention due to their high polymorphism. OBJECTIVES This study aimed to analyse the influence of KIR gene polymorphism in the course of OT infection and its association with recurrences after an active episode. METHODS Ninety-six patients from the Ophthalmologic Clinic of the National Institute of Infectology Evandro Chagas were followed for up to five years. After DNA extraction, genotyping of the patients was performed by polymerase chain reaction sequence-specific oligonucleotide (PCR-SSO) utilising Luminex equipment for reading. During follow-up, 60.4% had a recurrence. FINDINGS We identified 25 KIR genotypes and found a higher frequency of genotype 1 (31.7%) with worldwide distribution. We note that the KIR2DL2 inhibitor gene and the gene activator KIR2DS2 were more frequent in patients without recurrence. Additionally, we observed that individuals who carry these genes progressed recurrence episodes slowly compared to individuals who do not carry these genes. MAIN CONCLUSIONS The KIR2DL2 and KIR2DS2 are associated as possible protection markers against ocular toxoplasmosis recurrence (OTR). OT, , (OT) challenge (NK parasites gondii immunoglobulinlike immunoglobulin like (KIR episode Ninetysix Ninety six years extraction sequencespecific sequence specific PCRSSO PCR SSO (PCR-SSO reading followup, followup follow up, follow-up 604 60 4 60.4 2 31.7% 317 31 7 (31.7% distribution KIRDL DL KIR2DL KIRDS DS KIR2DS Additionally OTR. OTR . (OTR) (OT 6 60. 31.7 3 (31.7 (OTR 31. (31. (31 (3 (

https://doi.org/10.1590/0074-02760220203

Chikungunya virus infection in the southernmost state of Brazil was characterised by self-limited transmission (2017-2019) and a larger 2021 outbreak selflimited self limited 20172019 2017 2019 (2017-2019 202 2017201 201 (2017-201 20 201720 (2017-20 2 20172 (2017-2 (2017- (2017 (201 (20 (2 (
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Gregianini, Tatiana Schäffer

; Salvato, Richard Steiner

; Barcellos, Regina Bones

; Godinho, Fernanda Marques

; Ruivo, Amanda Pellenz

; de Melo, Viviane Horn

; Schroder, Júlio Augusto

; Martiny, Fernanda Letícia

; Möllmann, Erica Bortoli

; Favreto, Cátia

; Baethgen, Ludmila Fiorenzano

; Ferreira, Vithoria Pompermaier

; de Lima, Lívia Eidt

; Piazza, Cláudia Fasolo

; Machado, Taís Raquel Marcon

; Becker, Irina Marieta

; Ramos, Raquel Rocha

; Frölich, Guilherme Carey

; Rossetti, Alana Fraga

; Almeida, Lucas da Cunha

; Rodrigues, Tahiana Machado Antunes

; Bragança, Isabella Tabelli

; Campos, Aline Alves Scarpellini

; Manzoni, Verônica Baú

; Machado, Lais Ceschini

; da Silva, Luisa Maria Inácio

; de Oliveira, André Luiz Sá

; Paiva, Marcelo Henrique Santos

; Nunes, Zenaida Marion Alves

; de Almeida, Paula Rodrigues

; Demoliner, Meriane

; Gularte, Juliana Schons

; da Silva, Mariana Soares

; Filippi, Micheli

; Pereira, Vyctoria Malayhka de Abreu Góes

; Spilki, Fernando Rosado

; da Veiga, Ana Beatriz Gorini

; Wallau, Gabriel Luz

Memórias do Instituto Oswaldo Cruz

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2023, Volume 118 elocation e220259

Abstract: En | Text: En | PDF: En

BACKGROUND Chikungunya is a mosquito-borne virus that has been causing large outbreaks in the Americas since 2014. In Brazil, Asian-Caribbean (AC) and East-Central-South-African (ECSA) genotypes have been detected and lead to large outbreaks in several Brazilian states. In Rio Grande do Sul (RS), the southernmost state of Brazil, the first cases were reported in 2016. OBJECTIVES AND METHODS We employed genome sequencing and epidemiological investigation to characterise the Chikungunya fever (CHIKF) burden in RS between 2017-2021. FINDINGS We detected an increasing CHIKF burden linked to travel associated introductions and communitary transmission of distinct lineages of the ECSA genotype during this period. MAIN CONCLUSIONS Until 2020, CHIKV introductions were most travel associated and transmission was limited. Then, in 2021, the largest outbreak occurred in the state associated with the introduction of a new ECSA lineage. CHIKV outbreaks are likely to occur in the near future due to abundant competent vectors and a susceptible population, exposing more than 11 million inhabitants to an increasing infection risk. mosquitoborne mosquito borne 2014 Brazil AsianCaribbean Asian Caribbean AC (AC EastCentralSouthAfrican East Central South African (ECSA states RS, , (RS) 2016 (CHIKF 20172021. 20172021 2017 2021. 2021 2017-2021 period 2020 limited Then lineage population 1 risk 201 (RS 2017202 202 2017-202 20 201720 2017-20 2 20172 2017-2 2017-

https://doi.org/10.1590/0074-02760220259

Relação entre maturação sexual e indicadores antropométricos e pressóricos em adolescentes
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Santos, Luís Eduardo Soares dos

; Claro, Maísa de Lima

; Carvalho, David de Sousa

; Oliveira, Edina Araújo Rodrigues

; Silva, Ana Roberta Vilarouca da

; Machado, Ana Larissa Gomes

; Conde, Wolney Lisboa

; Lima, Luisa Helena de Oliveira

Ciência & Saúde Coletiva

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sep 2022, Volume 27 N. 9 Pages 3615 - 3626

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivou-se investigar a relação entre a maturação sexual com indicadores antropométricos e pressóricos de adolescentes. Estudo transversal de base populacional, realizado entre 2018 e 2020, com 345 adolescentes de 10 a 19 anos. Coletou-se variáveis sociodemográficas e antropométricas, pressão arterial e maturação sexual. A análise dos dados foi feita por meio da Análise de Componentes Principais, que gerou três componentes e, posteriormente, testou-se a correlação entre a maturação sexual e os componentes gerados. A maioria dos adolescentes eram do sexo feminino (53%), normotensos (66,1%) e com peso normal (73%). Houve correlação positiva entre o desenvolvimento das mamas com o componente 1 e o componente 2, e correlação negativa entre mamas e o componente 3. Nos meninos, o desenvolvimento dos genitais e pelos pubianos estiveram positivamente correlacionados com o componente 2 e inversamente correlacionados com o componente 3. Conclui-se que existe relação entre a maturação sexual e os indicadores antropométricos e pressóricos, sendo variáveis representativas de risco cardiovascular em adolescentes, mesmo que não em sua totalidade.

Abstract This study aimed to investigate the relationship between sexual maturation and anthropometric and blood pressure indicators in teenagers. This was a population-based cross-sectional study, conducted with 345 teenagers, aged 10 to 19 years, between 2018 and 2020. In this study, data referent to sociodemographic and anthropometric variables, blood pressure, and sexual maturation were collected. The data analysis was performed by applying the Principle Component Analysis (PCA), which generated three components and then tested the correlation between sexual maturation and the generated components. Most of the teenagers were female (53%), normotensive (66.1%), and with a normal weight (73%). A positive correlation was found between breast development and component 1 and component 2, as well as a negative correlation between the breasts and component 3. In the boys, the development of genitals and pubic hair was positively correlated with component 2 and inversely correlated with component 3. It could therefore be concluded that there is a relationship between sexual maturation and the anthropometric and blood pressure indicators, which proved to be representative variables for cardiovascular risk in teenagers, even if not in their entirety.

https://doi.org/10.1590/1413-81232022279.04622022

10.

Relação entre maturação sexual e indicadores antropométricos e pressóricos em adolescentes
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Santos, Luís Eduardo Soares dos

; Claro, Maísa de Lima

; Carvalho, David de Sousa

; Oliveira, Edina Araújo Rodrigues

; Silva, Ana Roberta Vilarouca da

; Machado, Ana Larissa Gomes

; Conde, Wolney Lisboa

; Lima, Luisa Helena de Oliveira

Ciência & Saúde Coletiva

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sep 2022, Volume 27 N. 9 Pages 3615 - 3626

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.1590/1413-81232022279.04622022

11.

Analysis of the "Diagnostic Reasoning" Concept in Nursing
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Silva, Bárbara Coeli Oliveira da

; Delgado, Millena Freire

; Nascimento, Rafaela Cavalcanti de Albuquerque

; Lira, Ana Luisa Brandão de Carvalho

; Feijão, Alexsandra Rodrigues

; Enders, Bertha Cruz

Aquichan

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jun 2022, Volume 22 N. 2 elocation e2222

Abstract: Es Pt En | Text: Es Pt En | PDF: Es | PDF: Pt | PDF: En

Resumen Objetivo: desarrollar una definición operacional del concepto "razonamiento diagnóstico" en enfermería. Materiales y métodos: se trata de un análisis de concepto según el modelo de Walker y Avant. Se siguieron todos los pasos de la referencia: selección del concepto; determinación de los objetivos y las propuestas para el análisis conceptual; identificación de los posibles usos del concepto; determinación de los atributos definidores; identificación de un caso modelo; identificación del caso contrario; identificación de los antecedentes y de las consecuencias del concepto. Resultados: se seleccionó una muestra de 20 estudios, en los que se identificaron los atributos: pensamiento especializado, habilidades cognitivas, conocimiento existente, competencia intelectual; razonamiento orientado a la hipótesis; antecedentes: evaluación clínica, experiencia práctica, interpretaciones de los datos, intuición, juicio diagnóstico, procesamiento de informaciones, razonamiento clínico; consecuencias: avance de los cuidados de enfermería, comunicación, planeación de intervenciones, actuación sobre el problema identificado, alcance de los resultados eficaces, acciones autónomas, calidad de la documentación del paciente. Conclusiones: el estudio aporta a la comprensión de la definición operacional del concepto "razonamiento diagnóstico" en enfermería por medio de la identificación de los atributos esenciales, de los antecedentes y de las consecuencias.

Resumo Objetivo: desenvolver uma definição operacional do conceito "raciocínio diagnóstico" em enfermagem. Materiais e métodos: trata-se de uma análise de conceito segundo o modelo de Walker e Avant. Foram seguidos todos os passos do referencial: seleção do conceito; determinação dos objetivos e das propostas para a análise conceitual; identificação dos possíveis usos do conceito; determinação dos atributos definidores; identificação de um caso modelo; identificação do caso contrários; identificação dos antecedentes e dos consequentes do conceito. Resultados: selecionou-se uma amostra de 20 estudos, nos quais foram identificados os atributos: pensamento especializado, habilidades cognitivas, conhecimento existente, competência intelectual; raciocínio orientado para a hipótese; antecedentes: avaliação clínica, experiência prática, interpretações dos dados, intuição, julgamento diagnóstico, processamento de informações, raciocínio clínico; consequentes: avanço dos cuidados de enfermagem, comunicação, planejamento de intervenções, agir sobre o problema identificado, alcance de resultados eficazes, ações autônomas, qualidade da documentação do paciente. Conclusões: o estudo contribui com a compreensão da definição operacional do conceito de raciocínio diagnóstico em enfermagem por meio da identificação dos atributos essenciais, dos antecedentes e dos consequentes.

Abstract Objective: To develop an operational definition of the "diagnostic reasoning" concept in nursing. Materials and methods: This concept analysis is based on Walker and Avant's model. All the referential steps were followed: concept selection, determining the objectives and proposals for concept analysis, identifying the possible uses of the concept, determining the defining attributes, identifying a model case, identifying the contrary case, and identifying the precedents and consequences of the concept. Results: A sample of 20 studies was selected, identifying the following attributes: specialized thinking, cognitive skills, existing knowledge, intellectual competence; hypothesis-oriented reasoning; precedents: clinical assessment, practical experience, data interpretations, intuition, diagnostic judgment, information processing, clinical reasoning; consequences: improvement of nursing care, communication, planning interventions, addressing the identified problem, achieving effective results, autonomous actions, and quality of patient records. Conclusions: The study contributes to understanding the operational definition of the diagnostic reasoning concept in nursing by identifying the core attributes, precedents, and consequences.

https://doi.org/10.5294/aqui.2022.22.2.2 63 downloads

12.

Normative values and reference equation for the six-minute step test to evaluate functional exercise capacity: a multicenter study
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Albuquerque, Vanessa Salles

; Corso, Simone Dal

; Amaral, Daniel Pereira do

; Oliveira, Túlio Medina Dutra de

; Souza, Gerson Fonseca

; Souza, Rachel Naara Silva de

; Nogueira, Ana Karolyn Menezes

; Lago, Pedro Dal

; Dadalt, Maria Luísa Rocha

; Correa, Isadora Faraco

; Cipriano, Graziella França Bernardelli

; Silva, Fabíola Maria Ferreira

; Britto, Raquel Rodrigues

; José, Anderson

; Malaguti, Carla

Jornal Brasileiro de Pneumologia

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2022, Volume 48 N. 4 elocation e20210511

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Estabelecer valores normativos e uma equação de referência para o número de degraus subidos no teste do degrau de seis minutos (TD6) em adultos saudáveis, bem como avaliar a confiabilidade do teste e da equação. Métodos: Estudo transversal multicêntrico com 468 voluntários saudáveis (faixa etária: 18-79 anos) recrutados na comunidade geral em seis laboratórios de pesquisa em diferentes regiões do Brasil, um país de dimensões continentais. O TD6 foi realizado duas vezes (com 30 min de intervalo entre uma e outra), e foram avaliadas variáveis clínicas, demográficas e funcionais. Uma amostra independente composta por 24 voluntários foi avaliada para testar a equação de referência a posteriori. Resultados: O número de degraus subidos apresentou excelente confiabilidade teste-reteste [coeficiente de correlação intraclasse = 0,96 (IC95%: 0,95-0,97)], e a média de degraus subidos foi de 175 ± 45, sendo 14% maior no sexo masculino. O melhor desempenho no teste correlacionou-se com as seguintes variáveis: idade (r = −0,60), sexo (r = 0,28), peso (r = 0,13), estatura (r = 0,41), IMC (r = −0,22), circunferência da cintura (r = −0,22), circunferência da coxa (r = 0,15), CVF (r = 0,54) e nível de atividade física (r = 0,17; p < 0,05 para todos). Na análise de regressão, idade, sexo, estatura e peso explicaram 42% da variabilidade do TD6. Foram estabelecidos valores normativos para o TD6 de acordo com a idade e o sexo. Não houve diferença entre os valores do TD6 na amostra independente e os valores previstos (157 ± 29 vs. 161 ± 25 degraus subidos; p = 0,47; 97% dos valores previstos). Conclusões: Os valores normativos e a equação de referência para o TD6 neste estudo parecem adequados para predizer com precisão o desempenho físico funcional em adultos no Brasil.

ABSTRACT Objective: To establish normative values and a reference equation for the number of steps climbed during the six-minute step test (6MST) in healthy adults, and to assess the reliability of the test and of the equation. Methods: This was a multicenter cross-sectional study involving 468 healthy volunteers (age range: 18-79 years) recruited from the general community in six research laboratories across different regions of Brazil, which is a country with continental dimensions. The 6MST was performed twice (30-min interval), and clinical, demographic, and functional variables were evaluated. An independent sample of 24 volunteers was evaluated to test the reference equation a posteriori. Results: The number of steps had excellent test-retest reliability (intraclass correlation coefficient = 0.96 [95%CI: 0.95-0.97]), and the mean number of steps was 175 ± 45, the number being 14% greater in males than in females. The best performance on the test was correlated with age (r = −0.60), sex (r = 0.28), weight (r = 0.13), height (r = 0.41), BMI (r = −0.22), waist circumference (r = −0.22), thigh circumference (r = 0.15), FVC (r = 0.54), and physical activity level (r = 0.17; p < 0.05 for all). In the regression analysis, age, sex, height, and weight explained 42% of the variability of the 6MST. Normative values were established for the 6MST according to age and sex. There was no difference between the 6MST values from the independent sample and its predicted values (157 ± 29 steps vs. 161 ± 25 steps; p = 0.47; 97% of predicted values). Conclusions: The normative values and the reference equation for the 6MST in this study seem adequate to accurately predict the physical functional performance in adults in Brazil.

https://doi.org/10.36416/1806-3756/e20210511

13.

Accuracy of the defining characteristics of the nursing diagnosis hypothermia in patients on hemodialysis
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Damasceno, Jackson Rodrigues

; Cavalcante, Tahissa Frota

; Ferreira, José Erivelton de Souza Maciel

; Barbosa, Eloise da Silva

; Moreira, Rafaella Pessoa

; Lopes, Marcos Venícios de Oliveira

; Lira, Ana Luisa Brandão de Carvalho

Revista Brasileira de Enfermagem

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2022, Volume 75 N. 4 elocation e20210620

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo: analisar a acurácia das características definidoras de hipotermia em pacientes em hemodiálise. Métodos: estudo de acurácia diagnóstica, com delineamento transversal, realizado com 124 pacientes de dois centros de diálise. Um modelo de classe latente foi utilizado para a análise de dados. Resultados: o diagnóstico de enfermagem hipotermia esteve presente em 13 (10,48%) participantes do estudo. As características definidoras mais prevalentes foram hipóxia (100%), redução da glicemia sanguínea (83,1%), hipertensão (65,3%), piloereção (45,2%) e pele fria ao toque (41,1%). As características definidoras acrocianose (99,96%) e leitos ungueais cianóticos (99,98%) apresentaram alta sensibilidade. Acrocianose (91,8%), pele fria ao toque (64,8%) e vasoconstrição periférica (91,8%) apresentaram alta especificidade. Conclusão: os indicadores específicos e sensíveis de hipotermia são bons indicadores clínicos para confirmar esse diagnóstico em pacientes em hemodiálise. Os resultados deste estudo podem auxiliar os enfermeiros em seu raciocínio clínico para uma inferência correta de hipotermia.

ABSTRACT Objective: to analyze the accuracy of the defining characteristics of hypothermia in patients on hemodialysis. Methods: a diagnostic accuracy study was assembled within a cross-sectional study with 124 patients from two dialysis centers. A latent class model was used for data analysis. Results: the nursing diagnosis hypothermia was present in 13 (10.48%) study participants. The most prevalent defining characteristics were hypoxia (100%), decrease in blood glucose level (83.1%), hypertension (65.3%), piloerection (45.2%), and skin cool to touch (41.1%). The defining characteristics acrocyanosis (99.96%) and cyanotic nail beds (99.98%) had a high sensitivity. Acrocyanosis (91.8%), skin cool to touch (64.8%), and peripheral vasoconstriction (91.8%) had high specificity. Conclusion: specific and sensitive indicators of hypothermia work as good clinical indicators for confirming this diagnosis in patients on hemodialysis. The study findings can assist nurses in their clinical reasoning for a correct inference of hypothermia.

RESUMEN Objetivo: analizar la exactitud de las características definitorias de la hipotermia en pacientes en hemodiálisis. Métodos: estudio de exactitud diagnóstica, con diseño transversal, realizado con 124 pacientes de dos centros de diálisis. Se utilizó un modelo de clases latentes para el análisis de datos. Resultados: el diagnóstico de enfermería hipotermia estuvo presente en 13 (10,48%) participantes del estudio. Las características definitorias más prevalentes fueron hipoxia (100%), reducción de la glucosa en sangre (83,1%), hipertensión (65,3%), piloerección (45,2%) y piel fría al tacto (41,1%). Las características definitorias de acrocianosis (99,96%) y lechos ungueales cianóticos (99,98%) mostraron alta sensibilidad. La acrocianosis (91,8%), la piel fría al tacto (64,8%) y la vasoconstricción periférica (91,8%) mostraran alta especificidad. Conclusión: los indicadores específicos y sensibles de hipotermia son buenos indicadores clínicos para confirmar este diagnóstico en pacientes en hemodiálisis. Los resultados del estudio pueden ayudar a las enfermeras a inferir correctamente la hipotermia.

https://doi.org/10.1590/0034-7167-2021-0620

14.

Recommendations by the Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology (DCNI/ABN) and the Brazilian Committee for Treatment and Research in Multiple Sclerosis and Neuroimmunological Diseases (BCTRIMS) on vaccination in general and specifically against SARS-CoV-2 for patients with demyelinating diseases of the central nervous system
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Becker, Jefferson

; Ferreira, Lis Campos

; Damasceno, Alfredo

; Bichuetti, Denis Bernardi

; Christo, Paulo Pereira

; Callegaro, Dagoberto

; Peixoto, Marco Aurélio Lana

; Sousa, Nise Alessandra De Carvalho

; Almeida, Sérgio Monteiro De

; Adoni, Tarso

; Santiago-Amaral, Juliana

; Junqueira, Thiago

; Pereira, Samira Luisa Apóstolos

; Gomes, Ana Beatriz Ayroza Galvão Ribeiro

; Pitombeira, Milena

; Paolilo, Renata Barbosa

; Grzesiuk, Anderson Kuntz

; Piccolo, Ana Claudia

; D´Almeida, José Arthur Costa

; Gomes Neto, Antonio Pereira

; Oliveira, Augusto Cesar Penalva De

; Oliveira, Bianca Santos De

; Tauil, Carlos Bernardo

; Vasconcelos, Claudia Ferreira

; Kaimen-Maciel, Damacio

; Varela, Daniel

; Diniz, Denise Sisterolli

; Oliveira, Enedina Maria Lobato De

; Malfetano, Fabiola Rachid

; Borges, Fernando Elias

; Figueira, Fernando Faria Andrade

; Gondim, Francisco De Assis Aquino

; Passos, Giordani Rodrigues Dos

; Silva, Guilherme Diogo

; Olival, Guilherme Sciascia Do

; Santos, Gutemberg Augusto Cruz Dos

; Ruocco, Heloisa Helena

; Sato, Henry Koiti

; Soares Neto, Herval Ribeiro

; Cortoni Calia, Leandro

; Gonçalves, Marcus Vinícius Magno

; Vecino, Maria Cecilia Aragón De

; Pimentel, Maria Lucia Vellutini

; Ribeiro, Marlise De Castro

; Boaventura, Mateus

; Parolin, Mônica Koncke Fiuza

; Melo, Renata Brant De Souza

; Lázaro, Robson

; Thomaz, Rodrigo Barbosa

; Kleinpaul, Rodrigo

; Dias, Ronaldo Maciel

; Gomes, Sidney

; Lucatto, Simone Abrante

; Alves-Leon, Soniza Vieira

; Fukuda, Thiago

; Ribeiro, Taysa Alexandrino Gonsalves Jubé

; Winckler, Thereza Cristina D’ávila

; Fragoso, Yara Dadalti

; Nascimento, Osvaldo José Moreira Do

; Ferreira, Maria Lucia Brito

; Mendes, Maria Fernanda

; Brum, Doralina Guimarães

; Glehn, Felipe Von

Arquivos de Neuro-Psiquiatria

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nov 2021, Volume 79 N. 11 Pages 1049 - 1061

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O DC de Neuroimunologia da ABN e o BCTRIMS trazem, nesse documento, as recomendações sobre vacinação da população com doenças desmielinizantes do sistema nervoso central (SNC) contra infecções em geral e contra o coronavírus da síndrome respiratória aguda grave 2 (SARS-CoV-2), causador da COVID-19. Destaca-se a gravidade do atual momento frente ao avanço da COVID-19 em nosso País, o que torna mais evidente e importante a criação de guia de referência para orientação aos médicos, pacientes e autoridades de saúde pública quanto à vacinação, meio efetivo e seguro no controle de determinadas doenças infecciosa. O DCNI/ABN e o BCTRIMS recomendam que os pacientes com doenças desmielinizantes do SNC (ex., EM e NMOSD) sejam constantemente monitorados, quanto a atualização do seu calendário vacinal, especialmente, no início ou antes da mudança do tratamento com uma droga modificadora de doença (DMD). É importante também salientar que as vacinas são seguras e os médicos devem estimular o seu uso em todos os pacientes. Evidentemente, deve ser dada especial atenção às vacinas com vírus vivos atenuados. Por fim, é importante que os médicos verifiquem qual DMD o paciente está em uso e quando foi feita a sua última dose, pois cada fármaco pode interagir de forma diferente com a indução da resposta imune.

ABSTRACT The Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology (DCNI/ABN) and Brazilian Committee for Treatment and Research in Multiple Sclerosis and Neuroimmunological Diseases (BCTRIMS) provide recommendations in this document for vaccination of the population with demyelinating diseases of the central nervous system (CNS) against infections in general and against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19. We emphasize the seriousness of the current situation in view of the spread of COVID-19 in our country. Therefore, reference guides on vaccination for clinicians, patients, and public health authorities are particularly important to prevent some infectious diseases. The DCNI/ABN and BCTRIMS recommend that patients with CNS demyelinating diseases (e.g., MS and NMOSD) be continually monitored for updates to their vaccination schedule, especially at the beginning or before a change in treatment with a disease modifying drug (DMD). It is also important to note that vaccines are safe, and physicians should encourage their use in all patients. Clearly, special care should be taken when live attenuated viruses are involved. Finally, it is important for physicians to verify which DMD the patient is receiving and when the last dose was taken, as each drug may affect the induction of immune response differently.

https://doi.org/10.1590/0004-282x-anp-2021-0162 1 downloads

15.

Projeto Integra: fortalecimento da participação social na agenda das políticas, serviços e tecnologias em saúde
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Leite, Silvana Nair

; Bermudez, Jorge Antonio Zepeda

; Melecchi, Débora

; Veiga, Adelir Rodrigues da

; Oliveira, Ana Liani Beisl

; Sousa, Artur Custódio Moreira de

; Chaves, Célia Machado Gervásio

; Manzini, Fernanda

; Dutra, Lidiane Silva

; Chaves, Luísa Arueira

; Pereira, Marco Aurélio

; Lima, Maria Eufrásia Oliveira

; Toniolo, Moysés Longinho

; Santos, Ronald Ferreira dos

; Dantas, Silvânia

; Costa, Jorge Carlos Santos da

Ciência & Saúde Coletiva

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nov 2021, Volume 26 N. 11 Pages 5589 - 5598

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A 16ª Conferência Nacional de Saúde demonstrou o interesse do controle social em intervir sobre as políticas públicas a fim de garantir o direito às tecnologias de saúde. O projeto Integra - Integração das Políticas de Vigilância em Saúde, Assistência Farmacêutica, Ciência, Tecnologia e Inovação em Saúde -, nasce da parceria entre o Conselho Nacional de Saúde, a Escola Nacional dos Farmacêuticos e a Fundação Oswaldo Cruz (Fiocruz), com apoio da Organização Pan-Americana de Saúde (OPAS) com objetivo de fortalecimento da participação e engajamento social na temática e a integração das políticas e práticas de saúde em diferentes setores da sociedade (movimentos sociais, controle social e profissionais de saúde), tendo as diversas etapas relacionadas ao acesso aos medicamentos (pesquisa, incorporação, produção nacional e serviços) como mote principal, no cenário da pandemia de COVID-19. Oferta-se, neste projeto, capacitação para grupos de lideranças nas regiões de saúde e atividades de grande abrangência nacional e política. Espera-se alcançar o estabelecimento de uma rede intersetorial, integrada de lideranças capazes de atuar colaborativamente para a defesa do desenvolvimento da ciência, das políticas públicas, da soberania nacional e do controle social da saúde.

Abstract The 16th National Health Conference illustrated the interest of health councils to intervene in public policies in order to guarantee the right to health technologies. The INTEGRA project (Integration of policies for Health Surveillance, Pharmaceutical Care, Science, Technology, and Innovation in Health) is a partnership among the National Health Council, the National School of Pharmacists, and the Oswaldo Cruz Foundation (Fiocruz), with support from the Pan American Health Organization (PAHO), with the goal of strengthening participation and social engagement in the theme, as well as the integration of health policies and practices within different sectors of society (social movements, health councils, and health professionals), with the various stages related to the access to medicines (research, incorporation, national production, and services) being the main theme in the context of the COVID-19 pandemic. It seeks to offer training for leadership groups in the health regions and activities with a broad national and political scope, and it hopes to establish an intersectorial and integrated network of leaders capable of acting collaboratively to defend the development of science, public policies, national sovereignty, and social control of health.

https://doi.org/10.1590/1413-812320212611.18212021 1 downloads

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Glossary and search help

You can enrich your search in a very simple way. Use the search indexes combined with the connectors (AND or OR) and specify more your search.

For example, if you want to search for articles about
cases of dengue in Brasil in 2015, use:
ti:dengue and publication_year:2015 and aff_country:Brasil

See below the complete list of search indexes that can be used:

Index code	Element
ti	article title
au	author
kw	article keywords
subject	subject (title words, abstract and keywords)
ab	abstract
ta	journal short title (e.g. Cad. Saúde Pública)
journal_title	journal full title (e.g. Cadernos de Saúde Pública)
la	publication language code (e.g. pt - Portuguese, es - Spanish)
type	document type
pid	publication identifier
publication_year	publication year of publication
sponsor	sponsor
aff_country	country code of the author's affiliation
aff_institution	author affiliation institution
volume	article volume
issue	article issue
elocation	elocation
doi	DOI number
issn	journal ISSN
in	SciELO colection code (e.g. scl - Brasil, col - Colômbia)
use_license	article usage license code

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