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Abstract Objective The current study delves into the accessibility of genetic evaluations for individuals with orofacial clefts (OC), comparing data between genetics and treatment centers across Brazil. Methods This cross-sectional retrospective study analyzed primary data from 1463 OC individuals registered in the Brazilian Database of Craniofacial Anomalies (BDCA) between 2008 and 2018 without age or sex selection. Diagnostic exam results stemming from research projects until 2023 were considered. Results Of the 1463 individuals with typical OC, 987 were non-syndromic, 462 were syndromic (SOC), 10 presented atypical forms, and three were not specified OC cases. The average age for accessing laboratory diagnosis was 8.5 years among SOC individuals. Notably, more SOC cases were registered in genetics centers than treatment and rehabilitation centers (37.1 % vs. 29 %, p = 0.0015). Those originating from genetics centers accessed diagnosis at an average age of 7.3 years, while those from treatment and rehabilitation centers experienced delays with an average age of 10.7 years (p = 0.0581). Conclusions Irrespective of the center of origin, the data highlight delayed diagnosis and challenges in accessing genetic tests for the syndromic group. Given the widespread reliance on the public health system by most of the Brazilian population, disseminating this data can significantly contribute to shaping an informed perspective on healthcare access. These insights can improve public policies tailored to the unique needs of individuals with OC. , (OC) Brazil crosssectional cross sectional 146 BDCA (BDCA 200 201 selection 202 considered 98 nonsyndromic, nonsyndromic non syndromic, non-syndromic 46 SOC, (SOC) 1 forms 85 8 5 8. Notably 37.1 371 37 (37. vs 2 0.0015. 00015 0.0015 . 0 0015 0.0015) 73 7 3 7. 107 10. 0.0581. 00581 0.0581 0581 0.0581) origin group population access (OC 14 20 9 4 (SOC 37. (37 0001 0.001 001 0058 0.058 058 (3 000 0.00 00 005 0.05 05 ( 0.0 0.

https://doi.org/10.1016/j.jped.2024.07.002

Clinical Characteristics of Genuine Acute Autoimmune Hepatitis
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Oliveira, Elze Maria Gomes

; Amaral, Ana Cristina de Castro

; Oliveira, Patricia Marinho Costa

; Lanzoni, Valéria Pereira

; Perez, Renata Mello

; Narciso-Schiavon, Janaína Luz

; Whale, Raul Carlos

; Carvalho-Filho, Roberto José

; Silva, Antonio Eduardo Benedito

; Ferraz, Maria Lucia Cardoso Gomes

GE-Portuguese Journal of Gastroenterology

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jun 2024, Volume 31 N. 3 Pages 21 - 29

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Introduction: Autoimmune hepatitis (AIH) has a spectrum of symptoms ranging from asymptomatic disease to acute severe hepatitis, chronic hepatitis, and decompensated cirrhosis. The acute presentation is not rare and could represent genuine acute AIH (GAAIH) or acute exacerbation of chronic autoimmune hepatitis. We aimed to identify the prevalence, clinical features, and prognostic factors associated with GAAIH and compare these cases with acute exacerbation of chronic AIH. Methods: This cross-sectional observational study evaluated patients with acute AIH presentation, deﬁned as total bilirubin >5 times the upper limit of normality (xULN) and/or alanine aminotransferase >10 xULN, and no prior history of liver disease. Histology ﬁndings of acute disease deﬁned GAAIH. Bivariate analyses were performed to identify factors associated with the GAAIH, when compared with acute exacerbation of chronic AIH. Results: Seventy-two patients with acute presentation of AIH were included and six (8.3%) of them presented GAAIH. Comparative analysis between patients with GAAIH and patients with acute exacerbation of chronic AIH revealed that prothrombin activity (96% [74-100] vs. 61% [10-100]; p = 0.003) and albumin levels (3.9 ± 0.2 g/dL vs. 3.4 ± 0.5 g/dL; p < 0.001) were higher in patients with GAAIH. The International Autoimmune Hepatitis Group score was higher in patients with acute exacerbation of chronic AIH (18.5 [8-23] vs. 16.5 [15-17]; p = 0.010). Compared to 15.2% of acute exacerbation of chronic AIH, complete therapeutic response to treatment was achieved in 67.7% of cases with GAAIH (p = 0.018). Conclusions: GAAIH was rare (8.3%), and patients with this presentation exhibited more preserved liver function tests, suggesting that most cases presenting with loss of function are acute exacerbation of chronic AIH. Additionally, patients with GAAIH had a better complete therapeutic response, suggesting a more preserved liver function at presentation, and early diagnosis has a positive therapeutic implication.

Resumo Introdução: A hepatite autoimune (HAI) apresenta um espectro de sintomas que varia de doença assintomática a hepatite aguda grave, hepatite crónica e cirrose descompensada. A apresentação aguda não é rara e pode representar hepatite autoimune aguda genuína (HAIAG) ou exacerbação aguda de hepatite autoimune crónica (EAHAIC). O nosso objetivo foi identiﬁcar a prevalência, caraterísticas clínicas e fatores prognósticos associados à HAIAG, e comparar esses casos com EAHAIC. Métodos: Estudo observacional, transversal, incluindo doentes com apresentação aguda de HAI, deﬁnida como bilirrubina total > 5 vezes o limite superior da normalidade (xLSN) e/ou ALT > 10 xLSN, e sem história prévia de doença hepática. HAIAG foi deﬁnida pela presença de achados histológicos de doença aguda. Análises bivariadas foram realizadas para identiﬁcar fatores associados à HAIAG, quando comparado com o EAHAIC. Resultados: Foram incluídos setenta e dois doentes com apresentação agu-da de HAI, dos quais seis (8.3%) com HAIAG. A análise comparativa entre doentes com HAIAG e doentes com EAHAIC mostrou que a atividade de protrombina (96%(74-100) versus 61% (10-100; p=0.003) e os níveis de albumina (3,9 ± 0,2 g/dL vs. 3,4 ± 0,5 g/dL; p < 0,001) foram signiﬁcativamente mais elevados em pacientes com HAIAG. O score do Grupo Internacional de Hepatite Autoimune foi mais elevado em doentes com EAHAIC (18.5 (8-23) versus 16.5 (15-17); p=0.010). A resposta terapêutica completa ao tratamento foi alcançada em 66.7% dos casos de HAIAG (vs. 15,2% na EAHAIC, p=0,018). Conclusões: A HAIAG é rara (8.3%), e os doentes com esta apresentação mostraram testes de função hepática mais preservados, sugerindo que a maioria dos casos com perda de função são EAHAIC. Além disso, os doentes com HAIAG tiveram maior taxa de resposta terapêutica completa, sugerindo que uma função hepática mais preservada na apresentação e o diagnóstico precoce tem uma implicação terapêutica positiva.

https://doi.org/10.1159/000531018

Infectious etiology and indicators of malabsorption or intestinal injury in childhood diarrhea
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Martins, Adson Santos

; Santos, Samara Alves

; Lisboa, Claudia Alves da Silva

; Barros, Tânia Fraga

; Ribeiro, Tereza Cristina Medrado

; Costa-Ribeiro Junior, Hugo da

; Mattos, Ângela Peixoto de

; Mendes, Patrícia Silva de Almeida

; Mendes, Carlos Maurício Cardeal

; Souza, Edna Lúcia

; Amor, Ana Lúcia Moreno

; Soares, Neci Matos

; Teixeira, Márcia Cristina Aquino

Biomédica

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mar 2024, Volume 44 N. 1 Pages 80 - 91

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Introduction. The multifactorial etiology of gastroenteritis emphasizes the need for different laboratory methods to identify or exclude infectious agents and evaluate the severity of diarrheal disease. Objective. To diagnose the infectious etiology in diarrheic children and to evaluate some fecal markers associated with intestinal integrity. Materials and methods. The study group comprised 45 children with diarrheal disease, tested for enteropathogens and malabsorption markers, and 76 children whose feces were used for fat evaluation by the traditional and acid steatocrit tests. Results. We observed acute diarrhea in 80% of the children and persistent diarrhea in 20%. Of the diarrheic individuals analyzed, 40% were positive for enteropathogens, with rotavirus (13.3%) and Giardia duodenalis (11.1%) the most frequently diagnosed. Among the infected patients, occult blood was more evident in those carrying pathogenic bacteria (40%) and enteroviruses (40%), while steatorrhea was observed in infections by the protozoa G. duodenalis (35.7%). Children with diarrhea excreted significantly more lipids in feces than non-diarrheic children, as determined by the traditional (p<0.0003) and acid steatocrit (p<0.0001) methods. Moreover, the acid steatocrit method detected 16.7% more fecal fat than the traditional method. Conclusions. Childhood diarrhea can lead to increasingly severe nutrient deficiencies. Steatorrhea is the hallmark of malabsorption, and a stool test, such as the acid steatocrit, can be routinely used as a laboratory tool for the semi-quantitative evaluation of fat malabsorption in diarrheic children.

Resumen Introducción. La etiología multifactorial de la gastroenteritis enfatiza la necesidad de usar diferentes métodos de laboratorio para identificar o excluir agentes infecciosos y evaluar la gravedad de la enfermedad diarreica. Objetivo. Diagnosticar la etiología infecciosa de la diarrea en niños y evaluar algunos marcadores fecales asociados con la integridad intestinal. Materiales y métodos. Se estudiaron 45 niños con enfermedad diarreica, en los cuales se evaluaron la presencia de enteropatógenos y los marcadores de malabsorción. Se analizaron las muestras fecales de 76 niños, mediante las pruebas de esteatocrito tradicional y esteatocrito ácido, para la cuantificación de la grasa. Resultados. Se observó diarrea aguda en el 80 % de los niños y diarrea persistente en el 20 %. De los individuos con diarrea, el 40 % fue positivo para enteropatógenos; los más diagnosticados fueron rotavirus (13,3 %) y Giardia duodenalis (11,1 %). Entre los pacientes infectados, la sangre oculta fue más evidente en aquellos portadores de bacterias patógenas (40 %) o enterovirus (40%), mientras que la esteatorrea se observó en infecciones por el protozoo G. duodenalis (35,7 %). Los niños con diarrea excretaron significativamente más lípidos en las heces que aquellos sin diarrea, según lo determinado por los métodos de esteatocrito tradicional (p<0,0003) y esteatocrito ácido (p<0,0001). Conclusiones. La diarrea infantil puede provocar deficiencias graves de nutrientes. La esteatorrea es distintiva de la malabsorción intestinal y puede detectarse mediante la estimación del esteatocrito ácido. Esta prueba podría utilizarse de forma rutinaria como una herramienta de laboratorio para la evaluación semicuantitativa de la malabsorción de grasas en niños con diarrea.

https://doi.org/10.7705/biomedica.6913

Trends and challenges for the application of probiotic lactic acid bacteria in functional foods
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Silva, Aline Sousa

; Casarotti, Sabrina Neves

; Penna, Ana Lúcia Barretto

Ciência Rural

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2024, Volume 54 N. 5 elocation e20230014

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Para as indústrias alimentícias é cada vez mais desafiador desenvolver de produtos que atendam às demandas dos consumidores. Eles buscam alimentos que sejam ao mesmo tempo produtos inovadores e apresentem efeitos benéficos à saúde. Neste trabalho, os objetivos principais são mostrar as tendências e inovações no mercado de lácteos e apontar os desafios para aplicação de bactérias probióticas em produtos não lácteos. Adicionalmente, a segurança das bactérias ácido-láticas (BAL) probióticas para uso em alimentos, e os efeitos dos probióticos na microbiota intestinal e na saúde humana também foram discutidos. Consideramos que o desenvolvimento de produtos fermentados probióticos com adição de frutas e subprodutos, cereais ou outros vegetais atende as tendências do mercado e a demanda dos consumidores. RESUMO consumidores trabalho Adicionalmente ácidoláticas ácido láticas BAL (BAL discutidos subprodutos

ABSTRACT: It is increasingly challenging for the food industries to develop products which meet the consumers’ demands. They seek foods that are innovative and present health benefits. In this review, the main objectives are to show the tendencies and innovations in the dairy food market and to indicate the challenges to apply probiotic bacteria to non-dairy products. Moreover, the safety of probiotic lactic acid bacteria (LAB) to be applied to food products and the beneficial effect of probiotic bacteria on the intestinal microbiota and overall human health were also discussed. We considered that the development of probiotic fermented products added with fruits and fruit by-products, cereals or other vegetables aligns with the market tendencies and the consumers’ demands. ABSTRACT consumers demands benefits review nondairy non Moreover LAB (LAB discussed byproducts, byproducts by products, by-products

https://doi.org/10.1590/0103-8478cr20230014

Excess mortality during the COVID-19 pandemic and its spatial distribution in the state of Pernambuco, Brazil: an ecological study
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Silva, Letícia Moreira

; Silva, Amanda Priscila de Santana Cabral

; Galvão, Maria Helena Rodrigues

; Silva, Ana Lúcia Andrade da

; Maia, Lívia Teixeira de Souza

Epidemiologia e Serviços de Saúde

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2024, Volume 33 elocation e20231014

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

ABSTRACT Objective To investigate excess mortality during the COVID-19 pandemic and its spatial distribution in Pernambuco, Brazil. Methods This was an ecological, descriptive and analytical study of deaths, by municipality, recorded on the Mortality Information System, in 2020 and 2021. Excess mortality was measured by comparing observed and expected deaths, the latter estimated by calculating standardized mortality ratio (SMR). SMR and respective confidence intervals (95%CI) were calculated. Spatial analysis was performed by calculating the Global and Local Moran Index. Results Excess mortality was 20.6% and 27.5%, respectively, in 2020 and 2021, with positive spatial correlation (p-value < 0.05). More populous municipalities (2020: SMR = 1.26; 95%CI 1.24;1.27 and 2021: SMR = 1.34; 95%CI 1.32;1.34), more developed municipalities (2020: SMR = 1.43; 95%CI 1.41;1.44 and 2021: SMR = 1.51;95%CI 1.50;1.53) and municipalities in the Sertão region (2020:SMR = 1.31;95%CI 1.30;1.33 and 2021: SMR = 1.44; 95%CI 1.42;1.46) showed greater excess deaths. Conclusion Excess mortality coincided with peak periods of COVID-19 transmission.

RESUMEN Objetivo Investigar el exceso de mortalidad durante la pandemia de Covid-19 y su distribución espacial en Pernambuco. Métodos Estudio ecológico, descriptivo y analítico de las defunciones, por municipio, registradas en el Sistema de Información de Mortalidad, en 2020 y 2021. El exceso de mortalidad se midió comparando las defunciones observadas y esperadas, estimada por tasas de mortalidad estandarizadas. Se calcularon la SMR y los respectivos intervalos de confianza (IC95%). El análisis espacial se realizó mediante el cálculo del Índice de Moran Global y Local. Resultados Hubo un exceso de mortalidad del 20,6% y 27,5%, respectivamente, en 2020 y 2021, y una correlación espacial positiva (valor p < 0,05). Municipios más poblados (2020: SMR = 1,26; IC95%: 1,24;1,27 y 2021: SMR = 1,34; IC95%: 1,32;1,34), más desarrollados (2020: SMR = 1,43; IC95%: 1,41;1,44 y 2021: SMR = 1,51; IC95%: 1,50;1,53) y Sertão (2020:SMR = 1,31;IC95%: 1,30;1,33 y 2021: SMR = 1,44; IC95%: 1,42;1,46) presentaron mayor exceso fallecidos. Conclusión El exceso de mortalidad coincidió con períodos pico de transmisión de Covid-19.

RESUMO Objetivo Investigar o excesso de mortalidade na pandemia de covid-19 e sua distribuição espacial no estado de Pernambuco. Métodos Estudo ecológico, descritivo e analítico dos óbitos, por município, registrados no Sistema de Informação sobre Mortalidade, em 2020 e 2021. O excesso de mortalidade foi mensurado comparando-se os óbitos observados e esperados, este último estimado pelo cálculo das taxas de mortalidade padronizadas. Foram calculados a standardized mortality ratio (SMR) e os respectivos intervalos de confiança (IC95%). A análise espacial foi realizada pelo cálculo do Índice de Moran Global e Local. Resultados Verificou-se excesso de mortalidade de 20,6% e de 27,5%, respectivamente, em 2020 e 2021, e correlação espacial positiva (p-valor < 0,05). Municípios mais populosos (2020: SMR = 1,26; IC95% 1,24;1,27 e 2021: SMR = 1,34; IC95% 1,32;1,34), mais desenvolvidos (2020: SMR = 1,43; IC95% 1,41;1,44 e 2021: SMR = 1,51; IC95% 1,50;1,53) e do Sertão (2020: SMR = 1,31; IC95% 1,30;1,33 e 2021: SMR = 1,44; IC95% 1,42;1,46) apresentaram maior excesso de mortes. Conclusão O excesso de mortalidade coincidiu com os períodos de pico de transmissão da covid-19.

https://doi.org/10.1590/s2237-96222024v33e20231014.en

Diretrizes Brasileiras de Medidas da Pressão Arterial Dentro e Fora do Consultório – 2023 202 20 2
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Feitosa, Audes Diogenes de Magalhães

; Barroso, Weimar Kunz Sebba

; Mion Junior, Decio

; Nobre, Fernando

; Mota-Gomes, Marco Antonio

; Jardim, Paulo Cesar Brandão Veiga

; Amodeo, Celso

; Oliveira, Adriana Camargo

; Alessi, Alexandre

; Sousa, Ana Luiza Lima

; Brandão, Andréa Araujo

; Pio-Abreu, Andrea

; Sposito, Andrei C.

; Pierin, Angela Maria Geraldo

; Paiva, Annelise Machado Gomes de

; Spinelli, Antonio Carlos de Souza

; Machado, Carlos Alberto

; Poli-de-Figueiredo, Carlos Eduardo

; Rodrigues, Cibele Isaac Saad

; Forjaz, Claudia Lucia de Moraes

; Sampaio, Diogo Pereira Santos

; Barbosa, Eduardo Costa Duarte

; Freitas, Elizabete Viana de

; Cestario, Elizabeth do Espirito Santo

; Muxfeldt, Elizabeth Silaid

; Lima Júnior, Emilton

; Campana, Erika Maria Gonçalves

; Feitosa, Fabiana Gomes Aragão Magalhães

; Consolim-Colombo, Fernanda Marciano

; Almeida, Fernando Antônio de

; Silva, Giovanio Vieira da

; Moreno Júnior, Heitor

; Finimundi, Helius Carlos

; Guimarães, Isabel Cristina Britto

; Gemelli, João Roberto

; Barreto-Filho, José Augusto Soares

; Vilela-Martin, José Fernando

; Ribeiro, José Marcio

; Yugar-Toledo, Juan Carlos

; Magalhães, Lucélia Batista Neves Cunha

; Drager, Luciano F.

; Bortolotto, Luiz Aparecido

; Alves, Marco Antonio de Melo

; Malachias, Marcus Vinícius Bolívar

; Neves, Mario Fritsch Toros

; Santos, Mayara Cedrim

; Dinamarco, Nelson

; Moreira Filho, Osni

; Passarelli Júnior, Oswaldo

; Vitorino, Priscila Valverde de Oliveira

; Miranda, Roberto Dischinger

; Bezerra, Rodrigo

; Pedrosa, Rodrigo Pinto

; Paula, Rogerio Baumgratz de

; Okawa, Rogério Toshiro Passos

; Póvoa, Rui Manuel dos Santos

; Fuchs, Sandra C.

; Lima, Sandro Gonçalves de

; Inuzuka, Sayuri

; Ferreira-Filho, Sebastião Rodrigues

; Fillho, Silvio Hock de Paffer

; Jardim, Thiago de Souza Veiga

; Guimarães Neto, Vanildo da Silva

; Koch, Vera Hermina Kalika

; Gusmão, Waléria Dantas Pereira

; Oigman, Wille

; Nadruz Junior, Wilson

Arquivos Brasileiros de Cardiologia

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2024, Volume 121 N. 4 elocation e20240113

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.36660/abc.20240113

Nutritional value and kinetics of in vitro fermentation of spineless cactus of the genus Nopalea in different phenological phases
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PESSOA, DIANA V.

; ANDRADE, ALBERICIO P. DE

; MAGALHÃES, ANDRÉ LUIZ R.

; TEODORO, ANA LÚCIA

; VALENÇA, ROBERTA L.

; CARDOSO, DANIEL B.

; SILVA, GABRIELA D.

; BARBOSA, STEYCE N.

; MACEDO, ELISON S. DE

; SANTOS, LUANA M. DOS

; SANTOS, DJALMA C. DOS

; ARAÚJO, FERNANDO S.

Anais da Academia Brasileira de Ciências

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2024, Volume 96 N. 3 elocation e20221001

Abstract: En | Text: En | PDF: En

Abstract The objective was to evaluate the chemical composition and in vitro fermentation of spineless cactus of the genus Nopalea, F-21 (Nopalea cochenillifera Dyck), IPA-Sertânia (Nopalea cochenillifera Dyck) and Miúda (Nopalea cochenillifera Salm Dyck), in different phenophases. There was no effect (P < 0.05) of the phenological phases of spineless cactus on DM, ash, OM, EE, and CP. Varieties F-21 and Miúda presented higher values of DM and OM, whereas the CP was higher for IPA-Sertânia. The contents of NDF, ADF, and ADL, as well as the fractions of carbohydrates B2 and C were higher in the mature stage, irrespective of the variety. The Miúda variety showed higher levels of NFC and fractions A + B1 and the lower levels of pectin compared to the F-21 and IPA-Sertânia varieties, but not differ of TC to F-21. The volume of gas produced via the degradation of NFC was higher for young phenological phases. The young and intermediate stages showed a higher in vitro digestibility of DM. Based on the results, varieties IPA-Sertânia and Miúda have a high potential for use in animal feed because of their high nutritional quality. Mature cladodes showed a higher fibrous fraction and lower digestibility in all varieties. Nopalea F21 F 21 F-2 Dyck, Dyck , IPASertânia IPA Sertânia phenophases P 0.05 005 0 05 ash OM EE IPASertânia. Sertânia. NDF ADF ADL B stage F21. 21. results quality F2 2 F- 0.0 00 0.

https://doi.org/10.1590/0001-3765202420221001

Interfaces between oncology and psychiatry
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Teles, Ana Luiza Silva

; Baldaçara, Leonardo

; Silva, Antônio Geraldo da

; Leite, Verônica da Silveira

; Benito, Ana Lucia Paya

; Ribeiro, Flávio Veloso

Revista da Associação Médica Brasileira

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2024, Volume 70 Suppl. 1 elocation e2024S129

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/1806-9282.2024s129

Effect of process parameters on the properties of LDPE/sepiolite composites LDPEsepiolite LDPE sepiolite
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Souza, Priscila da Silva e

; Sousa, Ana Maria Furtado de

; Silva, Ana Lúcia Nazareth da

Polímeros

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2024, Volume 34 N. 2 elocation e20240015

Abstract: En | Text: En | PDF: En

Abstract This study examines the effect of processing parameters and reactive extrusion on the mechanical, thermal, morphological, and rheological properties of low-density polyethylene (LDPE) and sepiolite composites (LDPE/sepiolite: 95/5 wt/wt) produced by in situ reactive extrusion in a twin-screw extruder. Using a design of experiments, the contribution of the factors reverse mixing elements (RE), maleic anhydride (MA), and dicumyl peroxide (DCP) was determined. The results showed that a better interaction between LDPE and sepiolite phases occurred when reactive extrusion was carried out, leading to a satisfactory balance between mechanical properties and thermal stability behavior. The rheology analysis revealed that a more pronounced solid-like behavior was achieved in the composite prepared by reactive extrusion and in the presence of the filler. The SEM micrographs showed the appearance of a network-like morphology in the composite processed in the presence of additives and sepiolite filler. morphological lowdensity low density (LDPE LDPE/sepiolite LDPEsepiolite (LDPE/sepiolite 955 95 5 95/ wt/wt wtwt wt twinscrew twin screw extruder experiments RE, RE , (RE) MA, MA (MA) DCP (DCP determined out solidlike solid like filler networklike network 9 (RE (MA

https://doi.org/10.1590/0104-1428.20230059

10.

Antioxidant activity and ultrastructural alterations in Leishmania amazonensis promastigotes induced by limonoid-rich fractions from andiroba oil limonoidrich limonoid rich
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ALMEIDA-SOUZA, Fernando

; OLIVEIRA, Iara dos Santos da Silva

; MAGALHÃES, Isadora de Fátima Braga

; TANIWAKI, Noemi Nosomi

; CALABRESE, Kátia da Silva

; ABREU-SILVA, Ana Lucia

Acta Amazonica

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2024, Volume 54 N. 1 elocation e54bc23113

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Na região Amazônica, o óleo de andiroba (Carapa guianensis) é um dos produtos mais utilizados pela população local devido às suas propriedades medicinais. Anteriormente, nosso grupo descreveu a atividade leishmanicida de três frações do óleo de andiroba ricas em limonóides. Este trabalho objetivou avaliar a atividade antioxidante e alterações ultraestruturais em Leishmania amazonensis tratadas com essas frações ricas em limonóides do óleo de andiroba: 6α,11β-diacetoxigedunina; 11β-hidroxigedunina; e uma fração com ambas 6α,11β-diacetoxigedunina + 11β-hidroxigedunina. A atividade antioxidante foi avaliada pelo método DPPH, e alterações ultraestruturais foram avaliadas por microscopia eletrônica de transmissão. A fração com ambas 6α,11β-diacetoxigedunina + 11β-hidroxigedunina exibiu a melhor atividade antioxidante (IC50 = 330,35 ± 8,60 µg mL-1; p = 0.0022) comparado com a fração 6α,11β-diacetoxigedunina. As três frações induziram alterações estruturais nas mitocôndrias e cinetoplasto de L. amazonensis, além de corpúsculos lipídicos, vacuolizações e vesículas na bolsa flagelar, indicando que as frações ricas em limonóides do óleo de andiroba podem induzir dano estrutural a Leishmania. Amazônica Carapa guianensis medicinais Anteriormente 6α,11βdiacetoxigedunina 6α11βdiacetoxigedunina αβdiacetoxigedunina 6α,11β diacetoxigedunina 6α 11β α β 11βhidroxigedunina βhidroxigedunina hidroxigedunina 11βhidroxigedunina. hidroxigedunina. DPPH transmissão IC50 IC (IC5 33035 330 35 330,3 860 8 60 8,6 mL1 mL 1 mL-1 0.0022 00022 0 0022 6α,11βdiacetoxigedunina. diacetoxigedunina. L lipídicos flagelar 11βdiacetoxigedunina βdiacetoxigedunina 6α11β αβ IC5 (IC 3303 33 3 330, 86 6 8, mL- 0.002 0002 002 0.00 000 00 0.0 0.

ABSTRACT In the Amazon region, andiroba (Carapa guianensis) oil is among the most used products by the local population due to its medicinal properties. Previously, our group described the leishmanicidal activity of three limonoid-rich fractions from andiroba oil. This work aimed to evaluate the antioxidant activity and ultrastructural changes in Leishmania amazonensis treated with these limonoid-rich fractions from andiroba oil: 6α,11β-diacetoxygedunin; 11β-hydroxygedunin; and a fraction with both 6α,11β-diacetoxygedunin +11β-hydroxygedunin. The antioxidant activity was evaluated by the DPPH method and ultrastructural changes were evaluated by transmission electron microscopy. The fraction with both 6α,11β-diacetoxygedunin + 11β-hydroxygedunin displayed the best antioxidant activity (IC50 330.35 ± 8.60 µg mL-1; p=0.0022) compared to the 6α,11β-diacetoxygedunin fraction. The three fractions induced structural changes to mitochondria and kinetoplasts of L. amazonensis, in addition to lipid bodies, vacuolization, and vesicles in the flagellar pocket, indicating that the limonoid-rich fractions from andiroba oil can induce structural damage to Leishmania. region Carapa guianensis properties Previously limonoidrich limonoid rich 6α,11βdiacetoxygedunin 6α11βdiacetoxygedunin αβdiacetoxygedunin 6α,11β diacetoxygedunin 6α 11β α β 11βhydroxygedunin βhydroxygedunin hydroxygedunin +11βhydroxygedunin. +11β hydroxygedunin. +11β-hydroxygedunin microscopy IC50 IC (IC5 33035 330 35 330.3 860 8 60 8.6 mL1 mL 1 mL-1 p=0.0022 p00022 p 0 0022 L bodies vacuolization pocket 11βdiacetoxygedunin βdiacetoxygedunin 6α11β αβ +11βhydroxygedunin IC5 (IC 3303 33 3 330. 86 6 8. mL- p=0.002 p0002 002 p=0.00 p000 00 p=0.0 p00 p=0. p0 p=0 p=

https://doi.org/10.1590/1809-4392202301131

11.

Interprofessionality in Brazilian national curricular guidelines for health courses
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Lima, Rebeca Benevides Dias

; Miranda, Elaine Silva

; Silva, Ana Lúcia Abrahão da

; Freitas, Silvia Eliza Almeida Pereira de

Avaliação: Revista da Avaliação da Educação Superior (Campinas)

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2024, Volume 29 elocation e024020

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Este estudo teve como objetivo analisar a inserção da interprofissionalidade nas Diretrizes Curriculares Nacionais (DCN) do Brasil vigentes dos cursos de graduação da área da saúde. Trata-se de uma pesquisa qualitativa de análise documental das diretrizes, dividida em duas etapas: leitura exploratória e análise dos documentos. As DCN vigentes dos cursos de graduação em saúde fazem referência ao trabalho em equipe, porém, há poucas referências à interprofissionalidade. As diretrizes publicadas após o Marco para ação em educação interprofissional e práticas colaborativas da Organização Mundial da Saúde (OMS) apresentaram mais referências à inserção da interprofissionalidade. Observou-se que a maioria das diretrizes dos cursos de graduação em saúde ainda insere a interprofissionalidade de forma escassa e pontual. (DCN Tratase Trata se etapas documentos equipe porém OMS (OMS Observouse Observou pontual

Abstract This study aimed to analyze the inclusion of interprofessionality in Brazil's National Curricular Guidelines (NCG) for undergraduate health courses. This is a qualitative research based on documentary analysis of the guidelines, divided into two stages: exploratory reading and document analysis. The current NCG for undergraduate health courses make references to teamwork, however, there are few mentions of interprofessionality. Guidelines published after the World Health Organization (WHO) Framework for action on interprofessional education and collaborative practices contain more references to the inclusion of interprofessionality. It was observed that most guidelines for undergraduate health courses still include interprofessionality in a limited and sporadic manner. Brazils Brazil s (NCG stages teamwork however WHO (WHO manner

Resumen Este estudio tuvo como objetivo analizar la inclusión de la interprofesionalidad en las directrices curriculares nacionales (DCN) de Brasil vigentes para carreras de pregrado del área de la salud. Se trata de una investigación cualitativa de análisis documental de las directrices dividida en dos etapas: lectura exploratoria y análisis de los documentos. Las Actuales Directrices para carreras de pregrado en salud hace referencia al trabajo en equipo, pero hay pocas referencias a la interprofesionalidad. Las Directrices publicadas tras el Marco de acción de la Organización Mundial de la Salud (OMS) sobre educación interprofesional y prácticas colaborativas presentaron más referencias a la inclusión de la interprofesionalidad. Se observó que la mayoría de las directrices de las carreras de pregrado en salud aún incluyen la interprofesionalidad de manera escasa y puntual. DCN (DCN etapas documentos equipo OMS (OMS puntual

https://doi.org/10.1590/1982-57652024v29id27937920

12.

Productive and nutritional attributes of hydroponic corn forage at different stages grown in elephant grass and wood sawdust substrates
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Cruz-Neiva, Tais Borges da

; Cerqueira, Julia de Castro

; Santos, Emilly Sabrina Cotrim dos

; Almeida, Raniere de Araújo Lima

; Silva, Hackson Santos da

; Candeias-Oliveira, Eliane Leal

; Andrade Sobrinho, Luiz Edmundo Cincurá de

; Oliveira, Kaliane Nascimento de

; Santana, Ana Lúcia Almeida

Ciência Animal Brasileira

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2024, Volume 25 elocation 78582E

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O objetivo foi avaliar atributos produtivos e nutricionais da forragem hidropônica de milho, em diferentes estágios, cultivada em substratos de capim-elefante e serragem de madeira. Foram estabelecidos dois tratamentos (T), com diferentes substratos: T1 - capim-elefante picado e desidratado e T2 - serragem de madeira. No 13º e 20º dias após a semeadura, amostras da forragem foram coletadas para avaliação do desenvolvimento das plântulas, produção de biomassa e composição nutricional. O substrato capim-elefante promoveu melhor desenvolvimento das plântulas, maior produção de biomassa e concentração de matéria mineral, aos 13 dias, quando a serragem de madeira promoveu maior concentração de matéria seca, proteína bruta, lignina e carboidrato não fibrosos (P<0,05). O substrato capim-elefante resultou em maior altura de plântula, produção de biomassa verde, concentração de matéria mineral, proteína bruta e extrato etéreo, aos 20 dias, quando a serragem de madeira promoveu maior comprimento de raíz, maior concentração de matéria seca, fibra em detergente ácido e lignina (P<0,05). O substrato capim-elefante e a coleta aos 13 dias promoveram melhor resultado para a produção de forragem hidropônica, bem como para a sua composição nutricional. milho estágios capimelefante capim elefante T, T , (T) º semeadura plântulas nutricional mineral 1 seca P<0,05. P005 P P<0,05 . 0 05 (P<0,05) plântula verde etéreo 2 raíz (T P00 P<0,0 (P<0,05 P0 P<0, (P<0,0 P<0 (P<0, P< (P<0 (P< (P

Abstract The objective of this study was to evaluate the productive and nutritional attributes of hydroponic corn forage grown on elephant grass and wood sawdust substrates at different stages. Two treatments (T) with different substrates were established: T1 - chopped and dehydrated elephant grass and T2 - wood sawdust. Forage samples were collected 13 and 20 days after sowing to evaluate seedling development, biomass production, and nutritional composition. The elephant grass substrate promoted better seedling development and greater biomass production and concentration of mineral matter at 13 days, whereas wood sawdust promoted a greater concentration of dry matter, crude protein, lignin, and non-fibrous carbohydrates (P < 0.05). The elephant grass substrates resulted in greater seedling height, production of green biomass, and concentrations of mineral matter, crude protein, and ether extract at 20 days, while wood sawdust promoted greater root length and greater concentrations of dry matter, acid detergent fiber, and lignin (P < 0.05). Elephant grass substrate and collection for 13 days promoted better production of hydroponic forage and its nutritional composition. stages T (T established 1 2 composition protein nonfibrous non fibrous P 0.05. 005 0.05 . 0 05 0.05) height fiber 00 0.0 0.

https://doi.org/10.1590/1809-6891v25e-78582e

13.

Recommendations on cutaneous and hematological manifestations of Sjögren’s disease by the Brazilian Society of Rheumatology Sjögrens Sjögren s
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Pugliesi, Alisson

; Egypto, Danielle Christinne Soares do

; Duffles, Guilherme

; Cantali, Diego Ustárroz

; Pasoto, Sandra Gofinet

; Oliveira, Fabiola Reis

; Valim, Valeria

; Lopes, Maria Lucia Lemos

; Miyamoto, Samira Tatiyama

; Fernandes, Marilena Leal Mesquita Silvestre

; Fialho, Sonia Cristina de Magalhães Souza

; Pinheiro, Aysa César

; Santos, Laura Caldas dos

; Appenzeller, Simone

; Ribeiro, Sandra Lucia Euzébio

; Libório-Kimura, Tatiana Nayara

; Santos, Maria Carmen Lopes Ferreira Silva

; Gennari, Juliana D´Agostino

; Pernanbuco, Roberta

; Capobiano, Karina Gatz

; Civile, Vinicius Tassoni

; Pinto, Ana Carolina Pereira Nunes

; Rocha-Filho, César Ramos

; Rocha, Aline Pereira da

; Trevisani, Virginia Fernandes Moça

Advances in Rheumatology

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2024, Volume 64 elocation 51

Abstract: En | Text: En | PDF: En

Abstract Sjogren’s disease (SjD) is an autoimmune disease that is characterized not only by the sicca symptoms it causes but also by its systemic nature, which is capable of several and not yet fully understood extraglandular manifestations. To gain a clearer understanding of these manifestations as well as a better practical approach, a panel of experts from the Brazilian Society of Rheumatology conducted a systematic review and meta-analysis on the identification of epidemiologic and clinical features of the extraglandular manifestations present in ESSDAI (EULAR Sjogren´s syndrome disease activity index), followed by a voting panel with recommendations for clinical practice. This publication is complementary to others already published and covers cutaneous and hematological manifestations, with prevalence data generated by a meta-analysis of 13 clinical or laboratory manifestations and 6 clinical management recommendations. Sjogrens Sjogren s SjD (SjD nature approach metaanalysis meta analysis EULAR index, index , index) practice 1

https://doi.org/10.1186/s42358-024-00391-x

14.

Serum osteoprotegerin and its gene polymorphisms in patients with Takayasu’s arteritis: a bicentric cross-sectional study Takayasus Takayasu s arteritis crosssectional cross sectional
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Duran, Camila da Silva Cendon

; Caparbo, Valéria de Falco

; Santiago, Mittermayer Barreto

; Hounkpe, Bidossessi Wilfried

; Pedreira, Ana Luisa Souza

; Lima, Isabella Vargas de Souza

; Giardini, Henrique Ayres Mayrink

; Bonoldi, Virgínia Lucia Nazario

; Domiciano, Diogo Souza

; Shinjo, Samuel Katsuyuki

; Pereira, Rosa Maria R

Advances in Rheumatology

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2024, Volume 64 elocation 43

Abstract: En | Text: En | PDF: En

Abstract Introduction Takayasu’s arteritis (TAK) patients are at an elevated risk of metabolic syndrome and cardiovascular diseases (CVD). Currently, there are no well-validated biomarkers to assess this risk in this population. Previous research in different cohorts has linked serum levels of osteoprotegerin (OPG) and its polymorphisms to accelerated atherosclerosis and a marker of poor prognosis in CVD. Thus, we assessed this protein as a potential biomarker of CVD in TAK patients. Objectives To evaluate the serum levels of OPG and its SNPs (single nucleotide polymorphisms) in TAK patients and healthy controls, and to associate these parameters with clinical data. Methods This bicentric cross-sectional study included TAK patients who were compared with healthy individuals (control group). The serum levels of OPG and the frequency of OPG SNPs [1181G > C (rs2073618), 245 A > C (rs3134069), 163T > C (rs3102735), and 209 C > T (rs3134070)] were compared between the both groups and associated with clinical data. Results In total, 101 TAK patients and 93 controls were included in the study. The serum levels of OPG (3.8 ± 1.9 vs. 4.3 ± 1.8pmol/L, respectively; P = 0.059), and its four polymorphisms were comparable between both groups. In an additional analysis of only TAK patients, serum OPG levels and its four genes were not associated with any CVD parameters, except for higher OPG levels among patients without dyslipidemia. Conclusion No significant differences were observed in serum OPG levels or in the genotype frequencies of OPG SNPs between the patient and control groups. Similarly, no correlation was found between laboratory parameters and clinical data on CVD risk in TAK patients. Takayasus Takayasu s (TAK . (CVD) Currently wellvalidated well validated population (OPG Thus single crosssectional cross sectional group. group group) 1181G G rs2073618, rs2073618 rs , (rs2073618) 24 rs3134069, rs3134069 (rs3134069) rs3102735, rs3102735 (rs3102735) 20 rs3134070 (rs3134070) total 10 9 3.8 38 3 8 (3. 19 1 1. vs 43 4 4. 18pmolL pmolL 8pmol L pmol 1.8pmol/L respectively 0.059, 0059 0.059 0 059 0.059) dyslipidemia Similarly (CVD rs207361 (rs2073618 2 rs313406 (rs3134069 rs310273 (rs3102735 rs313407 (rs3134070 3. (3 005 0.05 05 rs20736 (rs207361 rs31340 (rs313406 rs31027 (rs310273 (rs313407 ( 00 0.0 rs2073 (rs20736 rs3134 (rs31340 rs3102 (rs31027 0. rs207 (rs2073 rs313 (rs3134 rs310 (rs3102 rs20 (rs207 rs31 (rs313 (rs310 rs2 (rs20 rs3 (rs31 (rs2 (rs3 (rs

https://doi.org/10.1186/s42358-024-00384-w

15.

Thymidine-dependent Staphylococcus aureus and lung function in patients with cystic fibrosis: a 10-year retrospective case-control study Thymidinedependent Thymidine dependent fibrosis 10year year 10 casecontrol case control 1
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Tomaz, Ana Paula de Oliveira

; Souza, Dilair Camargo de

; Cogo, Laura Lucia

; Palmeiro, Jussara Kasuko

; Nogueira, Keite da Silva

; Petterle, Ricardo Rasmussen

; Riedi, Carlos Antonio

; Rosario Filho, Nelson Augusto

; Dalla-Costa, Libera Maria

Jornal Brasileiro de Pneumologia

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2024, Volume 50 N. 4 elocation e20240026

Abstract: En | Text: En | PDF: En

ABSTRACT Objective: Thymidine-dependent small-colony variants (TD-SCVs) of Staphylococcus aureus are being isolated with increasing frequency from patients with cystic fibrosis (CF). The aim of this study was to evaluate the relationship between TD-SCV isolation and pulmonary function in patients with CF, as well as to determine whether the emergence of TD-SCVs was associated with trimethoprim-sulfamethoxazole (TMP-SMX) use and with coinfection with other microorganisms. Methods: This was a retrospective case-control study including patients with CF who visited the Clinical Hospital Complex of the Federal University of Paraná, in Curitiba, Brazil, between 2013 and 2022. Demographic, clinical, and spirometric data, as well as information on TD-SCVs and other isolated microorganisms, were collected from the medical records of patients with CF and TD-SCVs (TD-SCV group; n = 32) and compared with those of a matched group of patients with CF without TD-SCVs (control group; n = 64). Results: Isolation of TD-SCVs was positively associated with TMP-SMX use (p = 0.009), hospitalization (p < 0.001), and impaired pulmonary function (p = 0.04). Conclusions: The use of TMP-SMX seems to contribute to the emergence of TD-SCVs, the isolation of which was directly associated with worse pulmonary function in our sample. Objective Thymidinedependent Thymidine dependent smallcolony small colony TDSCVs TD SCVs (TD-SCVs CF. . (CF) TDSCV SCV trimethoprimsulfamethoxazole trimethoprim sulfamethoxazole TMPSMX TMP SMX (TMP-SMX microorganisms Methods casecontrol case control Paraná Curitiba Brazil 201 2022 Demographic clinical data 32 64. 64 64) Results p 0.009, 0009 0.009 , 0 009 0.009) 0.001, 0001 0.001 001 0.001) 0.04. 004 0.04 04 0.04) Conclusions TDSCVs, SCVs, sample (CF 20 202 3 6 000 0.00 00 0.0 2 0.

https://doi.org/10.36416/1806-3756/e20240026

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