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Abstract The global syndemic is an issue that is gaining notoriety in the world. The syndemic is understood as the interaction between obesity, malnutrition and climate change, that is, synergy of epidemics and complex situations, which coexist in time and place and their consequences for health. However, little is known about the relationship between the global syndemic and the consumption of ultra-processed foods (UPF). In this context, the present essay aims to reflect on the relationship established between the global syndemic and the consumption of UPA. Starting with obesity, it is known that excessive consumption of UPA is one of the main causes of this chronic non-communicable disease. However, there is also a direct relationship between malnutrition and the consumption of UPA, since people who are in a situation of food insecurity choose economically accessible foods, characterizing themselves as a double burden of malnutrition. While studies on sustainable diets advance, knowledge about the association between climate change and UPA consumption is still incipient. Although studies highlight its environmental impacts in the handling and consumption of meat, in addition to the use of pesticides, it may play a secondary role. In this sense, studies are needed that evaluate the consumption of UPA and its relationship with the global syndemic, to support the formulation of public policies aimed at improving the consumption of healthy and sustainable foods for the planet.

Resumen La sindemia global es un tema que está ganando notoriedad en el mundo. La sindemia se entiende como la interacción entre la obesidad, la desnutrición y el cambio climático, es decir, sinergia de epidemias y situaciones complejas, que coexisten en tiempo y lugar y sus consecuencias para la salud. Sin embargo, poco se sabe sobre la relación entre la sindemia global y el consumo de alimentos ultraprocesados (AUP). En este contexto, el presente ensayo tiene como objetivo reflexionar acerca de la relación que se establece entre la sindemia global y el consumo de AUP. Empezando por la obesidad, se sabe que el consumo excesivo de AUP es una de las principales causas de esta enfermedad crónica no transmisible. Sin embargo, también existe una relación directa entre desnutrición y el consumo de AUP, ya que las personas que se encuentran en situación de inseguridad alimentaria eligen alimentos económicamente accesibles, caracterizándose como una doble carga de malnutrición. Mientras avanzan los estudios sobre las dietas sostenibles, el conocimiento sobre la asociación entre el cambio climático y el consumo de AUP es aún incipiente. Aunque los estudios destacan sus impactos ambientales en el manejo y consumo de carne, además del uso de pesticidas, pudiendo jugar un papel secundario. En este sentido, se necesitan estudios que evalúen el consumo de AUP y su relación con la sindemia global, para apoyar la formulación de políticas públicas encaminadas a mejorar el consumo de alimentos saludables y sostenibles para el planeta.

https://doi.org/10.4067/s0717-75182024000400340

Clinical Characteristics of Genuine Acute Autoimmune Hepatitis
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Oliveira, Elze Maria Gomes

; Amaral, Ana Cristina de Castro

; Oliveira, Patricia Marinho Costa

; Lanzoni, Valéria Pereira

; Perez, Renata Mello

; Narciso-Schiavon, Janaína Luz

; Whale, Raul Carlos

; Carvalho-Filho, Roberto José

; Silva, Antonio Eduardo Benedito

; Ferraz, Maria Lucia Cardoso Gomes

GE-Portuguese Journal of Gastroenterology

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jun 2024, Volume 31 N. 3 Pages 21 - 29

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Introduction: Autoimmune hepatitis (AIH) has a spectrum of symptoms ranging from asymptomatic disease to acute severe hepatitis, chronic hepatitis, and decompensated cirrhosis. The acute presentation is not rare and could represent genuine acute AIH (GAAIH) or acute exacerbation of chronic autoimmune hepatitis. We aimed to identify the prevalence, clinical features, and prognostic factors associated with GAAIH and compare these cases with acute exacerbation of chronic AIH. Methods: This cross-sectional observational study evaluated patients with acute AIH presentation, deﬁned as total bilirubin >5 times the upper limit of normality (xULN) and/or alanine aminotransferase >10 xULN, and no prior history of liver disease. Histology ﬁndings of acute disease deﬁned GAAIH. Bivariate analyses were performed to identify factors associated with the GAAIH, when compared with acute exacerbation of chronic AIH. Results: Seventy-two patients with acute presentation of AIH were included and six (8.3%) of them presented GAAIH. Comparative analysis between patients with GAAIH and patients with acute exacerbation of chronic AIH revealed that prothrombin activity (96% [74-100] vs. 61% [10-100]; p = 0.003) and albumin levels (3.9 ± 0.2 g/dL vs. 3.4 ± 0.5 g/dL; p < 0.001) were higher in patients with GAAIH. The International Autoimmune Hepatitis Group score was higher in patients with acute exacerbation of chronic AIH (18.5 [8-23] vs. 16.5 [15-17]; p = 0.010). Compared to 15.2% of acute exacerbation of chronic AIH, complete therapeutic response to treatment was achieved in 67.7% of cases with GAAIH (p = 0.018). Conclusions: GAAIH was rare (8.3%), and patients with this presentation exhibited more preserved liver function tests, suggesting that most cases presenting with loss of function are acute exacerbation of chronic AIH. Additionally, patients with GAAIH had a better complete therapeutic response, suggesting a more preserved liver function at presentation, and early diagnosis has a positive therapeutic implication.

Resumo Introdução: A hepatite autoimune (HAI) apresenta um espectro de sintomas que varia de doença assintomática a hepatite aguda grave, hepatite crónica e cirrose descompensada. A apresentação aguda não é rara e pode representar hepatite autoimune aguda genuína (HAIAG) ou exacerbação aguda de hepatite autoimune crónica (EAHAIC). O nosso objetivo foi identiﬁcar a prevalência, caraterísticas clínicas e fatores prognósticos associados à HAIAG, e comparar esses casos com EAHAIC. Métodos: Estudo observacional, transversal, incluindo doentes com apresentação aguda de HAI, deﬁnida como bilirrubina total > 5 vezes o limite superior da normalidade (xLSN) e/ou ALT > 10 xLSN, e sem história prévia de doença hepática. HAIAG foi deﬁnida pela presença de achados histológicos de doença aguda. Análises bivariadas foram realizadas para identiﬁcar fatores associados à HAIAG, quando comparado com o EAHAIC. Resultados: Foram incluídos setenta e dois doentes com apresentação agu-da de HAI, dos quais seis (8.3%) com HAIAG. A análise comparativa entre doentes com HAIAG e doentes com EAHAIC mostrou que a atividade de protrombina (96%(74-100) versus 61% (10-100; p=0.003) e os níveis de albumina (3,9 ± 0,2 g/dL vs. 3,4 ± 0,5 g/dL; p < 0,001) foram signiﬁcativamente mais elevados em pacientes com HAIAG. O score do Grupo Internacional de Hepatite Autoimune foi mais elevado em doentes com EAHAIC (18.5 (8-23) versus 16.5 (15-17); p=0.010). A resposta terapêutica completa ao tratamento foi alcançada em 66.7% dos casos de HAIAG (vs. 15,2% na EAHAIC, p=0,018). Conclusões: A HAIAG é rara (8.3%), e os doentes com esta apresentação mostraram testes de função hepática mais preservados, sugerindo que a maioria dos casos com perda de função são EAHAIC. Além disso, os doentes com HAIAG tiveram maior taxa de resposta terapêutica completa, sugerindo que uma função hepática mais preservada na apresentação e o diagnóstico precoce tem uma implicação terapêutica positiva.

https://doi.org/10.1159/000531018

[SciELO Preprints] - Guidelines on the Diagnosis and Treatment of Hypertrophic Cardiomyopathy – 2024
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Fernandes, Fabio Simões, Marcus V. Correia, Edileide de Barros Marcondes-Braga, Fabiana G. Coelho-Filho, Otavio Rizzi Mesquita, Cláudio Tinoco Mathias-Junior, Wilson Rochitte, Carlos Eduardo Ramires, Felix José Alvarez Alves, Silvia Marinho Martins Montera, Marcelo Westerlund Lopes, Renato Delascio Oliveira-Junior, Mucio Tavares Scolari, Fernando L. Avila, Walkiria Samuel Canesin, Manoel Fernandes Bacal, Fernando Bocchi, Edimar Alcides Moura, Lídia Ana Zytynski Saad, Eduardo Benchimol Scanavacca, Mauricio I. Valdigem, Bruno Pereira Cano , Manuel Nicolas Abizaid , Alexandre Ribeiro, Henrique Barbosa Lemos-Neto, Pedro Alves Ribeiro, Gustavo Calado de Aguiar Jatene, Fabio Biscegli Dias, Ricardo Ribeiro Beck-da-Silva, Luis Rohde, Luis Eduardo P. Bittencourt, Marcelo Imbroinise Pereira, Alexandre Krieger, José Eduardo Villacorta, Humberto Martins, Wolney de Andrade Figueiredo-Neto, José Albuquerque de Cardoso , Juliano Novaes Pastore, Carlos Alberto Jatene, Ieda Biscegli Tanaka, Ana Cristina Sayuri Hotta, Viviane Tiemi Romano, Minna Moreira Dias Albuquerque, Denilson Campos de Mourilhe-Rocha, Ricardo Hajjar, Ludhmila Abrahão Brito, Fabio Sandoli de Caramelli , Bruno Calderaro, Daniela Farsky, Pedro Silvio Colafranceschi , Alexandre Siciliano Pinto, Ibraim Masciarelli Vieira , Marcelo Luiz Campos Danzmann, Luiz Claudio Barberato , Silvio Henrique Mady, Charles Martinelli-Filho, Martino Torbey , Ana Flavia Malheiros Schwartzmann, Pedro Vellosa Macedo, Ariane Vieira Scarlatelli Ferreira , Silvia Moreira Ayub Schmidt, Andre Melo , Marcelo Dantas Tavares de Lima-Filho, Moysés Oliveira Sposito, Andrei C. Brito, Flavio de Souza Biolo, Andreia Madrini-Junior, Vagner Rizk, Stéphanie Itala Mesquita, Evandro Tinoco

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Publication date: 2024-04-08

Abstract: Pt Es En

A cardiomiopatia hipertrófica (CMH) é uma forma de doença do músculo cardíaco de causa genética, caracterizada pela hipertrofia das paredes ventriculares. O diagnóstico requer detecção por métodos de imagem (Ecocardiograma ou Ressonância Magnética Cardíaca) de qualquer segmento da parede do ventrículo esquerdo com espessura > 15 mm, sem outra causa provável. A análise genética permite identificar mutações de genes codificantes de diferentes estruturas do sarcômero responsáveis pelo desenvolvimento da CMH em cerca de 60% dos casos, permitindo o rastreio de familiares e aconselhamento genético, como parte importante do manejo dos pacientes e familiares. Vários conceitos sobre a CMH foram recentemente revistos, incluindo sua prevalência de 1 em 250 indivíduos, não sendo, portanto, uma doença rara, mas subdiagnosticada. A vasta maioria dos pacientes é assintomática. Naqueles sintomáticos, a obstrução do trato de saída do ventrículo esquerdo (OTSVE) é o principal distúrbio responsável pelos sintomas, devendo-se investigar a sua presença em todos os casos. Naqueles em que o ecocardiograma em repouso ou com Manobra de Valsalva não detecta gradiente intraventricular significativo (> 30 mmHg), devem ser submetidos à ecocardiografia com esforço físico para detecção da OTSVE.   Pacientes com sintomas limitantes e grave OTSVE, refratários ao uso de betabloqueadores e verapamil, devem receber terapias de redução septal ou uso de novas drogas inibidoras da miosina cardíaca. Por fim, os pacientes adequadamente identificados com risco aumentado de morta súbita podem receber medida profilática com implante de cardiodesfibrilador implantável (CDI).

La miocardiopatía hipertrófica (MCH) es una forma de enfermedad cardíaca de origen genético, caracterizada por el engrosamiento de las paredes ventriculares. El diagnóstico requiere la detección mediante métodos de imagen (Ecocardiograma o Resonancia Magnética Cardíaca) que muestren algún segmento de la pared ventricular izquierda con un grosor > 15 mm, sin otra causa probable. El análisis genético permite identificar mutaciones en genes que codifican diferentes estructuras del sarcómero responsables del desarrollo de la MCH en aproximadamente el 60% de los casos, lo que permite el tamizaje de familiares y el asesoramiento genético, como parte importante del manejo de pacientes y familiares. Varios conceptos sobre la MCH han sido revisados recientemente, incluida su prevalencia de 1 entre 250 individuos, por lo tanto, no es una enfermedad rara, sino subdiagnosticada. La gran mayoría de los pacientes son asintomáticos. En los casos sintomáticos, la obstrucción del tracto de salida ventricular izquierdo (TSVI) es el trastorno principal responsable de los síntomas, y su presencia debe investigarse en todos los casos. En aquellos en los que el ecocardiograma en reposo o la maniobra de Valsalva no detecta un gradiente intraventricular significativo (> 30 mmHg), deben someterse a ecocardiografía de esfuerzo para detectar la obstrucción del TSVI. Los pacientes con síntomas limitantes y obstrucción grave del TSVI, refractarios al uso de betabloqueantes y verapamilo, deben recibir terapias de reducción septal o usar nuevos medicamentos inhibidores de la miosina cardíaca. Finalmente, los pacientes adecuadamente identificados con un riesgo aumentado de muerte súbita pueden recibir medidas profilácticas con el implante de un cardioversor-desfibrilador implantable (CDI).

Hypertrophic cardiomyopathy (HCM) is a form of genetically caused heart muscle disease, characterized by the thickening of the ventricular walls. Diagnosis requires detection through imaging methods (Echocardiogram or Cardiac Magnetic Resonance) showing any segment of the left ventricular wall with a thickness > 15 mm, without any other probable cause. Genetic analysis allows the identification of mutations in genes encoding different structures of the sarcomere responsible for the development of HCM in about 60% of cases, enabling screening of family members and genetic counseling, as an important part of patient and family management. Several concepts about HCM have recently been reviewed, including its prevalence of 1 in 250 individuals, hence not a rare but rather underdiagnosed disease. The vast majority of patients are asymptomatic. In symptomatic cases, obstruction of the left ventricular outflow tract (LVOT) is the primary disorder responsible for symptoms, and its presence should be investigated in all cases. In those where resting echocardiogram or Valsalva maneuver does not detect significant intraventricular gradient (> 30 mmHg), they should undergo stress echocardiography to detect LVOT obstruction. Patients with limiting symptoms and severe LVOT obstruction, refractory to beta-blockers and verapamil, should receive septal reduction therapies or use new drugs inhibiting cardiac myosin. Finally, appropriately identified patients at increased risk of sudden death may receive prophylactic measure with implantable cardioverter-defibrillator (ICD) implantation.

https://doi.org/10.1590/SciELOPreprints.8394

Consensus of the Brazilian Association of Hematology, Hemotherapy and Cellular Therapy (ABHH) and the Brazilian Ministry of Health - General management of blood and blood products on the tests necessary for the release of exceptional medicines for sickle cell disease Hematology ABHH (ABHH
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Lobo, Clarisse

; Araújo, Aderson

; Antunes, Alexandre de Albuquerque

; Pinto, Ana Cristina Silva

; Godinho, Ariadne Carvalho

; Pires, Cassia Silvestre Mariano

; Matheus, Cinthia Cristina

; Albuquerque, Xerez de

; Neves, Daniele Campos Fontes

; Moreno, Fábio de Lima

; Baldanzi, Giorgio

; Siufi, Grazziella Curado

; Miranda, Heloisa Helena Pereira

; Hankins, Jane

; Aragão, Joice

; Braga, Josefina Aparecida Pellegrini

; Martins, Juliana Touguinha Neves

; Souza, Luciana Campos Costa Machado de

; Figueiredo, Maria Stella

; Oliveira, Mirella Rodrigues

; Cardoso, Patricia Santos Resende

; Pinto, Patricia Costa Alves

; Moura, Patricia Gomes

; Cançado, Rodolfo Delfini

; Araujo, Paulo Ivo Cortez de

; Saad, Sara Olalla

; Loggetto, Sandra Regina

; Fonseca, Teresa Cristina Cardoso

Hematology, Transfusion and Cell Therapy

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mar 2024, Volume 46 N. 1 Pages 67 - 71

Abstract: En | Text: En | PDF: En

Abstract To date, hydroxyurea is the only effective and safe drug that significantly reduces morbidity and mortality of individuals with Sickle cell disease. Twenty years of real-life experience has demonstrated that hydroxyurea reduces pain attacks, vaso-occlusive events, including acute chest syndrome, the number and duration of hospitalizations and the need for transfusion. The therapeutic success of hydroxyurea is directly linked to access to the drug, the dose used and adherence to treatment which, in part, is correlated to the availability of hydroxyurea. This consensus aims to reduce the number of mandatory exams needed to access the drug, prioritizing the requesting physician's report, without affecting patient safety. date disease reallife real life attacks vasoocclusive vaso occlusive events syndrome transfusion which part physicians physician s report safety

https://doi.org/10.1016/j.htct.2024.01.001

Participação social: teoria e prática na formação graduada em Terapia Ocupacional
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Silva, Ana Cristina Cardoso da

; Oliver, Fátima Correa

Interface - Comunicação, Saúde, Educação

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2024, Volume 28 elocation e240179

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

La participación social está en los debates sobre las transformaciones y la diversidad teórico-metodológica en la terapia ocupacional. Con ese contexto, se buscó identificar si la participación social, en su ámbito teórico-práctico, se aborda en el proceso de formación graduada en terapia ocupacional y cómo se aborda con los alumnos. De manera colaborativa, terapeutas ocupacionales docentes de instituciones de enseñanza superior públicas y privadas respondieron un cuestionario. La mayoría incluyó el concepto en las discusiones teóricas y en la construcción de prácticas y de investigaciones dentro y fuera del aula. Hay una relación entre los diferentes campos de actuación, enseñanza, investigación y extensión, los modos y metodologías de trabajo, la población atendida, sus contextos de vida, demandas y necesidades y los puntos de vista sobre la participación social. Eso ejemplifica la flexibilización de los currículos y la posibilidad de trazar diferentes caminos para la formación graduada.

Public participation is part of the debate about transformations and theoretical and methodological diversity in occupational therapy. The aim of this study was to identify whether theoretical and practical aspects of public participation are addressed in undergraduate occupational therapy training and how it has been approached with students. Occupational therapy teachers from public and private universities answered a questionnaire. Most teachers included the concept in theoretical discussions and the development of practices and research inside and outside the classroom. There is a relationship between different fields of work, teaching, research and extension, working methods and methodologies, the population treated and their life contexts, demands and needs, and points of view of public participation. This exemplifies the flexibilization of curriculums and the possibility to chart different pathways for undergraduate training.

A participação social está nos debates sobre as transformações e a diversidade teórico-metodológica na Terapia Ocupacional. Com esse contexto, buscou-se identificar se a participação social, em seu âmbito teórico-prático, é abordada no processo de formação graduada em Terapia Ocupacional e como tem sido trabalhada com os alunos. De maneira colaborativa, terapeutas ocupacionais docentes de instituições de ensino superior públicas e privadas responderam a um questionário. A maioria incluiu o conceito nas discussões teóricas e na construção de práticas e pesquisas dentro e fora da sala de aula. Há relação entre os diferentes campos de atuação; ensino; pesquisa e extensão; modos e metodologias de trabalho; população atendida; seus contextos de vida, demandas e necessidades; e os pontos de vista sobre a participação social. Isso exemplifica a flexibilização dos currículos e a possibilidade de traçar diferentes caminhos para formação graduada.

https://doi.org/10.1590/interface.240179

Certificação de doenças respiratórias agudas na declaração de óbito: um estudo de acurácia óbito
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Borges, Beatriz Alves Souza

; Silva, Cauê Sousa Cruze

; Penha, Lourena Bottentuit Cardoso

; Abreu, Luisa Caroline Costa

; Carvalho, Delmason Soares Barbosa de

; Machado, Ana Cristina

; Rego, Elaine Ramos de Moraes

; Lyrio, Amanda Oliveira

; Conceição, Sarah dos Santos

; Batista, Josicélia Estrela Tuy

; Pereira, Priscilla Perez da Silva

; Cruz, Simone Seixas da

; Figueiredo, Ana Cláudia Morais Godoy

; Souza, Elivan Silva

Cadernos Saúde Coletiva

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2024, Volume 32 N. 1 elocation e32010023

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Introdução: As doenças respiratórias agudas apresentam difícil mensuração e contribuem para o grande número de causas de óbito mal definidas, o que afeta a confiabilidade das informações de mortalidade. Objetivo: Verificar a acurácia da definição da causa básica de óbito para doenças respiratórias agudas dos óbitos registrados no Sistema de Informações sobre Mortalidade do Distrito Federal em 2018. Método: Foi realizado um estudo de acurácia, com amostra mínima de 331 declarações de óbito com as causas de óbito do capítulo 10 (doenças do aparelho respiratório — J00-J99 — conforme subcategorias) da Classificação Internacional de Doenças na versão 10, considerando a definição de causa básica de óbito pela equipe de investigação como o padrão-ouro. Foram calculadas a sensibilidade, especificidade, valores preditivos positivo e negativo e as razões de verossimilhanças positivas e negativas com os respectivos intervalos de confiança a 95%. Resultados: Total de 396 declarações de óbito foram incluídas. Foi constatada alta sensibilidade para identificar doenças pulmonares agudas nas causas básicas de óbito (82,8%. IC95% 78,6–86,5) e alta especificidade (93,1%. IC95% 77,2–99,2). A probabilidade de a declaração apresentar resultado falso negativo foi baixa (0,2. IC95% 0,1–0,2). Conclusão: As declarações de óbito por doenças respiratórias agudas apresentaram bons resultados para acurácia e incitam a realização de estudos semelhantes para outras condições. Introdução definidas mortalidade Objetivo 2018 Método 33 1 J00J99 JJ J00 J99 J J00-J9 subcategorias padrãoouro. padrãoouro padrão ouro. ouro padrão-ouro 95 95% Resultados 39 incluídas 82,8%. 828 82 8 (82,8% IC95 IC 78,6–86,5 786865 78 6 86 5 93,1%. 931 93 (93,1% 77,2–99,2. 772992 77,2–99,2 . 77 2 99 77,2–99,2) 0,2. 02 0 (0,2 0,1–0,2. 0102 0,1–0,2 0,1–0,2) Conclusão condições 201 3 J00J9 J0 J9 J00-J 9 82,8% (82,8 IC9 78,6–86, 78686 7 93,1% (93,1 77299 77,2–99, 0,2 (0, 010 0,1–0, 20 J00J 82,8 (82, 78,6–86 7868 93,1 (93, 7729 77,2–99 0, (0 01 0,1–0 82, (82 78,6–8 786 93, (93 772 77,2–9 ( 0,1– (8 78,6– (9 77,2– 0,1 78,6 77,2 78, 77,

Abstract Background: Acute respiratory diseases are difficult to measure and contribute to a large number of ill-defined causes of death, which affects the reliability of mortality information. Objective: To verify the accuracy of the definition of the underlying cause of death for acute respiratory diseases registered in the Mortality Information System of the Federal District in 2018. Method: An accuracy study was conducted, with a minimum sample of 331 death certificates with the causes of death according to Chapter 10 (diseases of the respiratory system — J00-J99 — according to subcategories) of the International Classification of Diseases, version 10, considering the definition of the underlying cause of death by the research team as the gold standard. Sensitivity, specificity, positive and negative predictive values, and positive and negative likelihood ratios were calculated with their respective 95% confidence intervals (CIs). Results: Overall, 396 death certificates were included. High sensitivity was identified to determine acute lung diseases in the underlying cause of death (82.8%, 95%CI 78.6–86.5) and high specificity (93.1%, 95%CI 77.2–99.2). The probability of the declaration shows that negative false value was low (0.2, 95%CI 0.1–0.2). Conclusion: Death certificates due to acute respiratory diseases showed good results for accuracy and this study encourages similar studies for other conditions. Background illdefined ill defined information Objective 2018 Method conducted 33 1 J00J99 JJ J00 J99 J J00-J9 subcategories Diseases standard Sensitivity values 95 CIs. CIs . (CIs) Results Overall 39 included 82.8%, 828 82 8 (82.8% 95CI CI 78.6–86.5 786865 78 6 86 5 93.1%, 931 93 (93.1% 77.2–99.2. 772992 77.2–99.2 77 2 99 77.2–99.2) 0.2, 02 0 (0.2 0.1–0.2. 0102 0.1–0.2 0.1–0.2) Conclusion conditions 201 3 J00J9 J0 J9 J00-J 9 (CIs 82.8% (82.8 78.6–86. 78686 7 93.1% (93.1 77299 77.2–99. 0.2 (0. 010 0.1–0. 20 J00J 82.8 (82. 78.6–86 7868 93.1 (93. 7729 77.2–99 0. (0 01 0.1–0 82. (82 78.6–8 786 93. (93 772 77.2–9 ( 0.1– (8 78.6– (9 77.2– 0.1 78.6 77.2 78. 77.

https://doi.org/10.1590/1414-462x202432010023

Participação social: teoria e prática na formação graduada em Terapia Ocupacional social
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Silva, Ana Cristina Cardoso da

; Oliver, Fátima Correa

Interface - Comunicação, Saúde, Educação

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2024, Volume 28 elocation e240179

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/interface.240179

Comparative in vitro activity of Delafloxacin and other antimicrobials against isolates from patients with acute bacterial skin, skin-structure infection and osteomyelitis skin skinstructure structure
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Ribeiro, Ághata Cardoso da Silva

; Santos, Fernanda Fernandes

; Valiatti, Tiago Barcelos

; Lenzi, Michael Henrique

; Santos, Ingrid Nayara Marcelino

; Neves, Raíssa Fidelis Baêta

; Moses, Ikechukwu Benjamin

; Meneses, Jaqueline Pilon de

; Sessa, Renata Gebara de Grande Di

; Salles, Mauro José

; Gales, Ana Cristina

Brazilian Journal of Infectious Diseases

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2024, Volume 28 N. 6 elocation 103867

Abstract: En | Text: En | PDF: En

ABSTRACT The aim of this study was to compare the in vitro activity of delafloxacin with other fluoro-quinolones against bacterial pathogens recovered from inpatients with osteomyelitis, Acute Bacterial Skin and Skin-Structure Infections (ABSSSI). In total, 100 bacterial isolates (58 % Gram-negative and 42 % Gram-positive) recovered from inpatients between January and April 2021, were reidentified at species level by MALDI-TOF MS. Antimicrobial susceptibility testing was conducted using the broth microdilution method and the detection of bio-film formation was assessed through the microtiter plate assay. The screening for mecA was carried out by PCR, while mutations in the Quinolone Resistance Determining Regions (QRDR), specifically gyrA and parC, were analyzed using PCR followed by Sanger sequencing. Results showed that delafloxacin exhibited greater in vitro potency (at least 64-times) than the other tested fluoroquinolones (levofloxacin and ciprofloxacin) when evaluating Staphylococcus aureus (MIC50 ≤0.008 mg/L) and coagulase-negative Staphylococcus (MIC50 0.06 mg/L). Furthermore, delafloxacin (MIC50 0.25 mg/L) was at least 4 times more potent than other tested fluoroquinolones (MIC50 1 mg/L) against P. aeruginosa. No difference in delafloxacin activity (MIC50 0.03 mg/L) was observed against Enterobacter cloacae when compared with ciprofloxacin (MIC50 0.03 mg/L). Despite presenting low activity against K. pneumoniae isolates (22.2 %), delafloxacin exhibited twice the activity compared to both levofloxacin and ciprofloxacin. Delafloxacin also exhibited a strong activity (71.4 %–85.7 %.) against biofilm producing bacterial pathogens tested in this study. Interestingly, 82.14 % of the staphylococci tested in this study harbored mecA gene. In addition, the gyrA and parC genes in fluoroquinolone-resistant Gram-negative isolates displayed different mutations (substitutions and deletions). Herein, we showed that delafloxacin was the most active fluoroquinolone against staphylococci (including MRSA) and P. aeruginosa when compared to other fluoroquinolones such as ciprofloxacin and levofloxacin. fluoro quinolones osteomyelitis SkinStructure Structure ABSSSI. ABSSSI . (ABSSSI) total 10 58 (5 Gramnegative Gram negative Grampositive positive Gram-positive 2021 MALDITOF MALDI TOF MS bio film assay QRDR, QRDR , (QRDR) sequencing 64times 64 64-times MIC50 MIC (MIC5 0008 0 008 ≤0.00 mg/L mgL mg L coagulasenegative coagulase 006 06 0.0 mg/L. Furthermore 025 25 0.2 P 003 03 K 22.2 222 22 2 (22. %, %) 71.4 714 71 (71. 857 85 7 %–85. %. Interestingly 8214 82 14 82.1 gene addition fluoroquinoloneresistant resistant substitutions deletions. deletions deletions) Herein including MRSA (ABSSSI 5 ( 202 (QRDR 6 MIC5 (MIC 000 00 ≤0.0 0. 02 22. (22 71. (71 8 %–85 821 82. 20 ≤0. (2 (7 %–8 ≤0 %– ≤

https://doi.org/10.1016/j.bjid.2024.103867

Safety of CoronaVac and ChAdOx1 vaccines against SARS-CoV-2 in patients with rheumatoid arthritis: data from the Brazilian multicentric study safer ChAdOx SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- arthritis SARS-CoV
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Cruz, Vitor Alves

; Guimarães, Camila

; Rêgo, Jozelia

; Machado, Ketty Lysie Libardi Lira

; Miyamoto, Samira Tatiyama

; Burian, Ana Paula Neves

; Dias, Laiza Hombre

; Pretti, Flavia Zon

; Batista, Danielle Cristina Filgueira Alves

; Mill, José Geraldo

; Oliveira, Yasmin Gurtler Pinheiro de

; Gadelha, Carolina Strauss Estevez

; Gouveia, Maria da Penha Gomes

; Moulin, Anna Carolina Simões

; Souza, Bárbara Oliveira

; Aguiar, Laura Gonçalves Rodrigues

; Vieira, Gabriel Smith Sobral

; Grillo, Luiza Lorenzoni

; Lima, Marina Deorce de

; Pasti, Laís Pizzol

; Surlo, Heitor Filipe

; Faé, Filipe

; Moulaz, Isac Ribeiro

; Macabú, Mariana de Oliveira

; Ribeiro, Priscila Dias Cardoso

; Magalhães, Vanessa de Oliveira

; Aguiar, Mariana Freitas de

; Biegelmeyer, Erika

; Peixoto;, Flávia Maria Matos Melo Campos

; Kayser, Cristiane

; Souza, Alexandre Wagner Silva de

; Castro, Charlles Heldan de Moura

; Ribeiro, Sandra Lúcia Euzébio

; Telles, Camila Maria Paiva França

; Bühring, Juliana

; Lima, Raquel Lima de

; Santos, Sérgio Henrique Oliveira Dos

; Dias, Samuel Elias Basualto

; Melo, Natália Seixas de

; Sanches, Rosely Holanda da Silva

; Boechat, Antonio Luiz

; Sartori, Natália Sarzi

; Hax, Vanessa

; Dória, Lucas Denardi

; Rezende, Rodrigo Poubel Vieira de

; Baptista, Katia Lino

; Fortes, Natália Rodrigues Querido

; Melo, Ana Karla Guedes de

; Melo, Tâmara Santos

; Vieira, Rejane Maria Rodrigues de Abreu

; Vieira, Adah Sophia Rodrigues

; Kakehasi, Adriana Maria

; Tavares, Anna Carolina Faria Moreira Gomes

; Landa, Aline Teixeira de

; Costa, Pollyana Vitoria Thomaz da

; Azevedo, Valderilio Feijó

; Martins-Filho, Olindo Assis

; Peruhype-Magalhães, Vanessa

; Pinheiro, Marcelo de Medeiros

; Monticielo, Odirlei André

; Reis-neto, Edgard Torres Dos

; Ferreira, Gilda Aparecida

; Souza, Viviane Angelina de

; Teixeira-Carvalho, Andréa

; Xavier, Ricardo Machado

; Sato, Emilia Inoue

; Valim, Valeria

; Pileggi, Gecilmara Salviato

; Silva, Nilzio Antonio da

Advances in Rheumatology

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2024, Volume 64 elocation 58

Abstract: En | Text: En | PDF: En

Abstract Background Patients with immune-mediated rheumatic diseases (IMRDs) have been prioritized for COVID-19 vaccination to mitigate the infection severity risks. Patients with rheumatoid arthritis (RA) are at a high risk of severe COVID-19 outcomes, especially those under immunosuppression or with associated comorbidities. However, few studies have assessed the safety of the COVID-19 vaccine in patients with RA. Objective To evaluate the safety of vaccines against SARS-CoV-2 in patients with RA. Methods This data are from the study “Safety and Efficacy on COVID-19 Vaccine in Rheumatic Diseases,” a Brazilian multicentric prospective phase IV study to evaluate COVID-19 vaccine in IMRDs in Brazil. Adverse events (AEs) in patients with RA of all centers were assessed after two doses of ChAdOx1 (Oxford/AstraZeneca) or CoronaVac (Sinovac/Butantan). Stratification of postvaccination AEs was performed using a diary, filled out daily and returned at the end of 28 days for each dose. Results A total of 188 patients with RA were include, 90% female. CoronaVac was used in 109 patients and ChAdOx1 in 79. Only mild AEs were observed, mainly after the first dose. The most common AEs after the first dose were pain at the injection (46,7%), headache (39,4%), arthralgia (39,4%), myalgia (30,5%) and fatigue (26,6%), and ChAdOx1 had a higher frequency of pain at the injection (66% vs 32 %, p < 0.001) arthralgia (62% vs 22%, p < 0.001) and myalgia (45% vs 20%, p < 0.001) compared to CoronaVac. The more common AEs after the second dose were pain at the injection (37%), arthralgia (31%), myalgia (23%), headache (21%) and fatigue (18%). Arthralgia (41,4% vs 25%, p = 0.02) and pain at injection (51,4% vs 27%, p = 0.001) were more common with ChAdOx1. No serious AEs were related. With Regard to RA activity level, no significant difference was observed between the three time periods for both COVID-19 vaccines. Conclusion In the comparison between the two immunizers in patients with RA, local reactions and musculoskeletal symptoms were more frequent with ChAdOx1 than with CoronaVac, especially after the first dose. In summary, the AE occurred mainly after the first dose, and were mild, like previous data from others immunizing agents in patients with rheumatoid arthritis. Vaccination did not worsen the degree of disease activity. immunemediated immune mediated (IMRDs COVID19 COVID 19 COVID-1 risks (RA outcomes comorbidities However SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- Safety Diseases, Diseases Brazil (AEs ChAdOx Oxford/AstraZeneca OxfordAstraZeneca Oxford AstraZeneca (Oxford/AstraZeneca Sinovac/Butantan. SinovacButantan Sinovac/Butantan . Sinovac Butantan (Sinovac/Butantan) diary 18 include 90 female 10 79 46,7%, 467 46,7% , 46 7 (46,7%) 39,4%, 394 39,4% 39 4 (39,4%) 30,5% 305 30 5 (30,5% 26,6%, 266 26,6% 26 6 (26,6%) 66% 66 (66 3 % 0.001 0001 0 001 62% 62 (62 22 22% 45% 45 (45 20 20% 37%, 37 37% (37%) 31%, 31 31% (31%) 23%, 23 23% (23%) 21% 21 (21% 18%. 18% (18%) 41,4% 414 41 (41,4 25 25% 0.02 002 02 51,4% 514 51 (51,4 27 27% related level summary COVID1 1 COVID- SARS-CoV (Sinovac/Butantan 9 46,7 (46,7% 39,4 (39,4% 30,5 (30,5 26,6 (26,6% (6 0.00 000 00 (4 (37% (31% (23% (21 (18% 41,4 (41, 0.0 51,4 (51, 46, (46,7 39, (39,4 30, (30, 26, (26,6 ( (37 (31 (23 (2 (18 41, (41 0. 51, (51 (46, (39, (30 (26, (3 (1 (5 (46 (39 (26

https://doi.org/10.1186/s42358-024-00397-5

10.

Dietary pattern among vulnerable puerperal women and their relation with food insecurity in the Northeast of Brazil
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Soares, Larissa de Lima

; Longo-Silva, Giovana

; Silveira, Jonas Augusto Cardoso da

; Silva-Neto, Luiz Gonzaga Ribeiro

; Freire, Jéssica Karlla Silva

; Marinho, Patrícia de Menezes

; Leal, Vanessa Sá

; Oliveira, Juliana Souza

; Clemente, Ana Paula Grotti

; Menezes, Risia Cristina Egito de

Revista Brasileira de Saúde Materno Infantil

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2024, Volume 24 elocation e20240070

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivos: identificar padrões alimentares (PA) de mulheres pós-parto e avaliar o efeito da insegurança alimentar, da idade e do nível de escolaridade no PA não saudável. Métodos: Coorte realizada por processo de amostragem consecutiva não probabilística em município da região Nordeste do Brasil, entre 2017-2018. A partir dos questionários de frequência alimentar, foram derivados PA por análises de componentes principais no 3º (n=207), 6º (n=195) e 12º mês (n=183) pós-parto. As associações entre os PA e as variáveis independentes foram investigadas utilizando modelo de regressão logística de efeitos mistos. Resultados: foram identificados dois padrões alimentares: PA predominantemente saudável (PAPS) e PA predominantemente ultraprocessado (PAPUP). Identificou-se que quanto maior a idade (OR= 0,92; IC95%= 0,85-0,99; p=0,031) e o nível de escolaridade (OR= 0,81; IC95%= 0,70-0,93; p=0,003), menor foi a chance de adesão ao PAPUP. Famílias com algum nível de insegurança alimentar apresentaram maior chance de aderir ao PAPUP (OR= 1,55; IC95%= 1,01-2,37; p=0,044). Conclusão: a adesão ao PAPUP aumenta com o nível de insegurança alimentar. A maior idade e nível de escolaridade diminuem a adesão a esse PA. Esses achados fornecem suporte para a associação entre insegurança alimentar, idade e escolaridade com a adesão ao PAPUP, sugerindo a necessidade de medidas eficazes para garantir a segurança alimentar, particularmente para populações vulneráveis. Objetivos (PA pósparto pós parto Métodos Brasil 20172018. 20172018 2017 2018. 2018 2017-2018 º n=207, n207 n n=207 , 207 (n=207) n=195 n195 195 (n=195 n=183 n183 183 (n=183 pósparto. parto. mistos Resultados PAPS (PAPS . (PAPUP) Identificouse Identificou se OR= OR (OR 0,92 092 0 92 IC95 IC IC95% 0,850,99 085099 0,85 0,99 85 99 0,85-0,99 p=0,031 p0031 p 031 0,81 081 81 0,700,93 070093 0,70 0,93 70 93 0,70-0,93 p=0,003, p0003 p=0,003 003 p=0,003) 1,55 155 1 55 1,012,37 101237 1,01 2,37 01 2 37 1,01-2,37 p=0,044. p0044 p=0,044 044 p=0,044) Conclusão vulneráveis 2017201 201 2017-201 n20 n=20 20 (n=207 n=19 n19 19 (n=19 n=18 n18 18 (n=18 (PAPUP 0,9 09 9 IC9 850 0,850,9 08509 085 0,8 099 8 0,85-0,9 p=0,03 p003 03 08 700 0,700,9 07009 070 0,7 093 7 0,70-0,9 p000 p=0,00 00 1,5 15 5 012 1,012,3 10123 101 1,0 237 2,3 3 1,01-2,3 p004 p=0,04 04 201720 2017-20 n2 n=2 (n=20 n=1 n1 (n=1 0, 0,850, 0850 0,85-0, p=0,0 p00 0,700, 0700 07 0,70-0, 1, 1,012, 1012 10 23 2, 1,01-2, 20172 2017-2 n= (n=2 (n= 0,850 0,85-0 p=0, p0 0,700 0,70-0 1,012 1,01-2 2017- (n 0,85- p=0 0,70- 1,01- p=

Abstract Objectives: to identify dietary patterns (DP) ofpostpartum women and to evaluate the effect of food insecurity, age, and level of schooling on unhealthy DP. Methods: Cohort carried out by non-probabilistic consecutive sampling process in a city in the Northeast region in Brazil, between 2017-2018. From the food frequency questionnaires, DP were derived by principal component analysis in the 3rd (n=207), 6th (n=195), and 12th month (n=183) postpartum. The associations between DP and the independent variables were investigated using mixed effects logistic regression model. Results: two dietary patterns were identified: predominantly healthy DP (PHDP) and predominantly ultra-processed DP (PUPDP). It was found that the higher the age (OR= 0.92; CI95%= 0.85-0.99; p=0.031) and the level of schooling (OR= 0.81; CI95%= 0.70-0.93; p=0.003), the lower the chance of adherence to PUPDP. Families with some level of food insecurity were more likely to adhere to PUPDP (OR= 1.55; CI95%= 1.01-2.37;p=0.044). Conclusion: adherence to PUPDP increases with the level of food insecurity. The higher age and level of schooling decrease adherence to this DP. These findings provide support for the association between food insecurity, age and education with adherence to PUPDP, suggesting the needfor effective measures to ensure food security, particularly for vulnerable populations. Objectives (DP Methods nonprobabilistic non probabilistic Brazil 20172018. 20172018 2017 2018. 2018 2017-2018 questionnaires rd n=207, n207 n n=207 , 207 (n=207) th n=195, n195 n=195 195 (n=195) n=183 n183 183 (n=183 postpartum model Results identified PHDP (PHDP ultraprocessed ultra processed . (PUPDP) OR= OR (OR 0.92 092 0 92 CI95 CI CI95% 0.850.99 085099 0.85 0.99 85 99 0.85-0.99 p=0.031 p0031 p 031 0.81 081 81 0.700.93 070093 0.70 0.93 70 93 0.70-0.93 p=0.003, p0003 p=0.003 003 p=0.003) 1.55 155 1 55 1.012.37p=0.044. 101237p0044 1.01 2.37 p=0.044 01 2 37 044 1.01-2.37;p=0.044) Conclusion security populations 2017201 201 2017-201 n20 n=20 20 (n=207 n19 n=19 19 (n=195 n=18 n18 18 (n=18 (PUPDP 0.9 09 9 CI9 850 0.850.9 08509 085 0.8 099 8 0.85-0.9 p=0.03 p003 03 08 700 0.700.9 07009 070 0.7 093 7 0.70-0.9 p000 p=0.00 00 1.5 15 5 012 37p 1.012.37p=0.044 101237p004 101 1.0 237 2.3 p0044 p=0.04 3 04 1.01-2.37;p=0.044 201720 2017-20 n2 n=2 (n=20 n1 n=1 (n=19 (n=1 0. 0.850. 0850 0.85-0. p=0.0 p00 0.700. 0700 07 0.70-0. 1. 1.012.37p=0.04 101237p00 10 23 2. p004 1.01-2.37;p=0.04 20172 2017-2 n= (n=2 (n= 0.850 0.85-0 p=0. p0 0.700 0.70-0 1.012.37p=0.0 101237p0 1.01-2.37;p=0.0 2017- (n 0.85- p=0 0.70- 1.012.37p=0. 101237p 1.01-2.37;p=0. p= 1.012.37p=0 1.01-2.37;p=0 1.012.37p= 1.01-2.37;p= 1.012.37p 1.01-2.37;p

https://doi.org/10.1590/1806-9304202400000070-en

11.

COVID-Inconfidentes - SARS-CoV-2 seroprevalence in two Brazilian urban areas in the fourth quarter 2020: study protocol and initial results
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Meireles, Adriana Lúcia

; Garcia Lourenção, Luciano

; Alves de Menezes Júnior, Luiz Antônio

; Nascimento Coletro, Hillary

; Sousa Justiniano, Irene Carolina

; Silva de Moura, Samara

; Popolino Diniz, Amanda

; da Silva Sabião, Thaís

; Sampaio Rocha, Ana Maria

; Batista, Aline Priscila

; Nunes Lage, Nara

; dos Santos Simões, Bárbara

; Ali Santos, Carolina

; de Deus Mendonça, Raquel

; de Souza Andrade, Amanda Cristina

; Furbino Barbosa, Keila

; Zumerle Masioli, Cássio

; Cardoso Carraro, Júlia Cristina

; Carvalho de Menezes, Mariana

; Rezende Macedo Nascimento, Renata Cristina

; Roever, Leonardo

; Teixeira Caiaffa, Waleska

; Lins Machado Coelho, George Luiz

Población y Salud en Mesoamérica

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dec 2023, Volume 21 N. 1 Pages 15 - 37

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Objective: To describe study protocol and initial results of research project COVID-Inconfidentes. Method: This paper described the methodological procedures adopted and the prevalence of the SARS-CoV-2 infection in the population. A household survey was conducted between October and December 2020, in two historic cities of Brazil's mining region. Anti-SARS-CoV-2 antibody was detected using the Wondfo® rapid test. The face-to face interview consisted of administration of a questionnaire containing registration data, sociodemographic and economic variables, living habits, general health condition, mental health, sleep habits, and eating and nutrition. Results: We evaluated 1,762 residents, of which 764 (43.4 %) were in Mariana and 998 (56.6 %) in Ouro Preto. For both cities, 51.9 % of the interviewees were female, with a predominance of the age range 35 to 59 years old (47.2 %). The prevalence of the SARS-CoV-2 infection was 5.5 % in both cities, 6.2 % in Ouro Preto, and 4.7 % in Mariana (p-value > 0.05). Conclusion: The study was effective to estimate the seroprevalence of infection by the virus and its findings will enable further analyses of the health conditions of the population related to social isolation and the risk of infection with SARS-CoV-2.

Resumen Describir el protocolo de estudio y los resultados iniciales del proyecto de investigación COVID Inconfidentes. Método: Este artículo describe los procedimientos metodológicos adoptados y la prevalencia de la infección por SARS-CoV-2 en la población. Se realizó una encuesta domiciliaria entre octubre y diciembre de 2020, en dos ciudades históricas de la región minera de Brasil. El anticuerpo anti-SARS-CoV-2 se detectó mediante la prueba rápida Wondfo®. La entrevista cara a cara consistió en la administración de un cuestionario que contenía datos de registro, variables sociodemográficas y económicas, hábitos de vida, estado general de salud, salud mental, hábitos de sueño, alimentación y nutrición. Resultados: Se evaluaron 1.762 habitantes, de los cuales 764 (43,4 %) estaban en Mariana y 998 (56,6 %) en Ouro Preto. Para ambas ciudades, el 51,9 % de los entrevistados eran del sexo femenino, con predominio del rango de edad de 35 a 59 años (47,2 %). La prevalencia de la infección por SARS-CoV-2 fue del 5,5 % en ambos municipios, del 6,2 % en Ouro Preto y del 4,7 % en Mariana (p > 0,05). Conclusión: El estudio fue efectivo para estimar la seroprevalencia de infección por el virus y sus hallazgos permitirán analizar más las condiciones de salud de la población relacionadas con el aislamiento social y el riesgo de infección por SARS-CoV-2.

https://doi.org/10.15517/psm.v21i1.53127

12.

IMPACTO-MR: um estudo brasileiro de plataforma nacional para avaliar infecções e multirresistência em unidades de terapia intensiva IMPACTOMR IMPACTO MR IMPACTO-MR
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Tomazini, Bruno M

; Nassar Jr, Antonio Paulo

; Lisboa, Thiago Costa

; Azevedo, Luciano César Pontes de

; Veiga, Viviane Cordeiro

; Catarino, Daniela Ghidetti Mangas

; Fogazzi, Debora Vacaro

; Arns, Beatriz

; Piastrelli, Filipe Teixeira

; Dietrich, Camila

; Negrelli, Karina Leal

; Jesuíno, Isabella de Andrade

; Reis, Luiz Fernando Lima

; Mattos, Renata Rodrigues de

; Pinheiro, Carla Cristina Gomes

; Luz, Mariane Nascimento

; Spadoni, Clayse Carla da Silva

; Moro, Elisângela Emilene

; Bueno, Flávia Regina

; Sampaio, Camila Santana Justo Cintra

; Silva, Débora Patrício

; Baldassare, Franca Pellison

; Silva, Ana Cecilia Alcantara

; Veiga, Thabata

; Barbante, Leticia

; Lambauer, Marianne

; Campos, Viviane Bezerra

; Santos, Elton

; Santos, Renato Hideo Nakawaga

; Laranjeiras, Ligia Nasi

; Valeis, Nanci

; Santucci, Eliana

; Miranda, Tamiris Abait

; Patrocínio, Ana Cristina Lagoeiro do

; Carvalho, Andréa de

; Sousa, Eduvirgens Maria Couto de

; Sousa, Ancelmo Honorato Ferraz de

; Malheiro, Daniel Tavares

; Bezerra, Isabella Lott

; Rodrigues, Mirian Batista

; Malicia, Julliana Chicuta

; Silva, Sabrina Souza da

; Gimenes, Bruna dos Passos

; Sesin, Guilhermo Prates

; Zavascki, Alexandre Prehn

; Sganzerla, Daniel

; Medeiros, Gregory Saraiva

; Santos, Rosa da Rosa Minho dos

; Silva, Fernanda Kelly Romeiro

; Cheno, Maysa Yukari

; Abrahão, Carolinne Ferreira

; Oliveira Junior, Haliton Alves de

; Rocha, Leonardo Lima

; Nunes Neto, Pedro Aniceto

; Pereira, Valéria Chagas

; Paciência, Luis Eduardo Miranda

; Bueno, Elaine Silva

; Caser, Eliana Bernadete

; Ribeiro, Larissa Zuqui

; Fernandes, Caio Cesar Ferreira

; Garcia, Juliana Mazzei

; Silva, Vanildes de Fátima Fernandes

; Santos, Alisson Junior dos

; Machado, Flávia Ribeiro

; Souza, Maria Aparecida de

; Ferronato, Bianca Ramos

; Urbano, Hugo Corrêa de Andrade

; Moreira, Danielle Conceição Aparecida

; Souza-Dantas, Vicente Cés de

; Duarte, Diego Meireles

; Coelho, Juliana

; Figueiredo, Rodrigo Cruvinel

; Foreque, Fernanda

; Romano, Thiago Gomes

; Cubos, Daniel

; Spirale, Vladimir Miguel

; Nogueira, Roberta Schiavon

; Maia, Israel Silva

; Zandonai, Cassio Luis

; Lovato, Wilson José

; Cerantola, Rodrigo Barbosa

; Toledo, Tatiana Gozzi Pancev

; Tomba, Pablo Oscar

; Almeida, Joyce Ramos de

; Sanches, Luciana Coelho

; Pierini, Leticia

; Cunha, Mariana

; Sousa, Michelle Tereza

; Azevedo, Bruna

; Dal-Pizzol, Felipe

; Damasio, Danusa de Castro

; Bainy, Marina Peres

; Beduhn, Dagoberta Alves Vieira

; Jatobá, Joana D’Arc Vila Nova

; Moura, Maria Tereza Farias de

; Rego, Leila Rezegue de Moraes

; Silva, Adria Vanessa da

; Oliveira, Luana Pontes

; Sodré Filho, Eliene Sá

; Santos, Silvana Soares dos

; Neves, Itallo de Lima

; Leão, Vanessa Cristina de Aquino

; Paes, João Lucidio Lobato

; Silva, Marielle Cristina Mendes

; Oliveira, Cláudio Dornas de

; Santiago, Raquel Caldeira Brant

; Paranhos, Jorge Luiz da Rocha

; Wiermann, Iany Grinezia da Silva

; Pedroso, Durval Ferreira Fonseca

; Sawada, Priscilla Yoshiko

; Prestes, Rejane Martins

; Nascimento, Glícia Cardoso

; Grion, Cintia Magalhães Carvalho

; Carrilho, Claudia Maria Dantas de Maio

; Dantas, Roberta Lacerda Almeida de Miranda

; Silva, Eliane Pereira

; Silva, Antônio Carlos da

; Oliveira, Sheila Mara Bezerra de

; Golin, Nicole Alberti

; Tregnago, Rogerio

; Lima, Valéria Paes

; Silva, Kamilla Grasielle Nunes da

; Boschi, Emerson

; Buffon, Viviane

; Machado, André Sant’Ana

; Capeletti, Leticia

; Foernges, Rafael Botelho

; Carvalho, Andréia Schubert de

; Oliveira Junior, Lúcio Couto de

; Oliveira, Daniela Cunha de

; Silva, Everton Macêdo

; Ribeiro, Julival

; Pereira, Francielle Constantino

; Salgado, Fernanda Borges

; Deutschendorf, Caroline

; Silva, Cristofer Farias da

; Gobatto, Andre Luiz Nunes

; Oliveira, Carolaine Bomfim de

; Dracoulakis, Marianna Deway Andrade

; Alvaia, Natália Oliveira Santos

; Souza, Roberta Machado de

; Araújo, Larissa Liz Cardoso de

; Melo, Rodrigo Morel Vieira de

; Passos, Luiz Carlos Santana

; Vidal, Claudia Fernanda de Lacerda

; Rodrigues, Fernanda Lopes de Albuquerque

; Kurtz, Pedro

; Shinotsuka, Cássia Righy

; Tavares, Maria Brandão

; Santana, Igor das Virgens

; Gavinho, Luciana Macedo da Silva

; Nascimento, Alaís Brito

; Pereira, Adriano J

; Cavalcanti, Alexandre Biasi

Revista Brasileira de Terapia Intensiva

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dec 2022, Volume 34 N. 4 Pages 418 - 425

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Descrever o IMPACTO-MR, um estudo brasileiro de plataforma nacional em unidades de terapia intensiva focado no impacto das infecções por bactérias multirresistentes relacionadas à assistência à saúde. Métodos: Descrevemos a plataforma IMPACTO-MR, seu desenvolvimento, critérios para seleção das unidades de terapia intensiva, caracterização da coleta de dados, objetivos e projetos de pesquisa futuros a serem realizados na plataforma. Resultados: Os dados principais foram coletados por meio do Epimed Monitor System® e consistiram em dados demográficos, dados de comorbidades, estado funcional, escores clínicos, diagnóstico de internação e diagnósticos secundários, dados laboratoriais, clínicos e microbiológicos e suporte de órgãos durante a internação na unidade de terapia intensiva, entre outros. De outubro de 2019 a dezembro de 2020, 33.983 pacientes de 51 unidades de terapia intensiva foram incluídos no banco de dados principal. Conclusão: A plataforma IMPACTO-MR é um banco de dados clínico brasileiro de unidades de terapia intensiva focado na pesquisa do impacto das infecções por bactérias multirresistentes relacionadas à assistência à saúde. Essa plataforma fornece dados para o desenvolvimento e pesquisa de unidades de terapia intensiva individuais e ensaios clínicos observacionais e prospectivos multicêntricos. Objetivo IMPACTOMR, IMPACTOMR IMPACTO MR, MR saúde Métodos Resultados System demográficos comorbidades funcional secundários laboratoriais outros 201 2020 33983 33 983 33.98 5 principal Conclusão multicêntricos 20 202 3398 3 98 33.9 2 339 9 33.

ABSTRACT Objective: To describe the IMPACTO-MR, a Brazilian nationwide intensive care unit platform study focused on the impact of health care-associated infections due to multidrug-resistant bacteria. Methods: We described the IMPACTO-MR platform, its development, criteria for intensive care unit selection, characterization of core data collection, objectives, and future research projects to be held within the platform. Results: The core data were collected using the Epimed Monitor System® and consisted of demographic data, comorbidity data, functional status, clinical scores, admission diagnosis and secondary diagnoses, laboratory, clinical, and microbiological data, and organ support during intensive care unit stay, among others. From October 2019 to December 2020, 33,983 patients from 51 intensive care units were included in the core database. Conclusion: The IMPACTO-MR platform is a nationwide Brazilian intensive care unit clinical database focused on researching the impact of health care-associated infections due to multidrug-resistant bacteria. This platform provides data for individual intensive care unit development and research and multicenter observational and prospective trials. Objective IMPACTOMR, IMPACTOMR IMPACTO MR, MR careassociated associated multidrugresistant multidrug resistant bacteria Methods selection collection objectives Results System status scores diagnoses laboratory stay others 201 2020 33983 33 983 33,98 5 Conclusion trials 20 202 3398 3 98 33,9 2 339 9 33,

https://doi.org/10.5935/0103-507x.20220209-pt

13.

A participação social como um caminho possível para a justiça social e ocupacional
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Silva, Ana Cristina Cardoso da

; Oliver, Fátima Corrêa

Cadernos Brasileiros de Terapia Ocupacional

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2022, Volume 30 N. spe elocation e3081

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Introdução Justiça social, justiça ocupacional e participação social são termos utilizados por terapeutas ocupacionais e cientistas ocupacionais para nortear, construir e informar suas práticas, formação profissional, pesquisas e produções teóricas. Objetivo Identificar e refletir sobre as possibilidades, limites e desafios da prática de terapeutas ocupacionais brasileiras na busca pela participação social e como isso pode ou não contribuir para construção da justiça social e ocupacional. Método Por meio de uma metodologia colaborativa, terapeutas ocupacionais docentes e da assistência, atuantes no estado de São Paulo, Brasil, foram convidadas a responderem um questionário. Com esse instrumento, buscou-se caracterizar as colaboradoras, conhecer o trabalho desenvolvido nos contextos de ensino, pesquisa, extensão e assistência e identificar como discutem e realizam a participação social nos campos teórico e prático. Resultados As 65 colaboradoras estavam inseridas em instituições públicas, privadas e filantrópicas, em diferentes campos de saber e de prática, e desenvolviam trabalhos e estudos com/para várias populações com demandas e necessidades específicas. Elas descreveram distintas possibilidades de participação social, algumas de natureza individual, focada no sujeito e na funcionalidade e outras orientadas para e com base no coletivo. Os limites e desafios estiveram relacionados às instituições de trabalho, aos aspectos individuais, coletivos e estruturais e ao próprio núcleo de saber e de prática da terapia ocupacional. Conclusão Com embasamento nas experiências das colaboradoras e na compreensão das profissionais sobre participação social, considera-se que esse pode ser um caminho teórico-conceitual e prático para refletir e buscar justiça social e ocupacional junto a indivíduos, grupos e comunidades.

Abstract Introduction Social justice, occupational justice, and social participation are terms used by occupational therapists and occupational scientists to guide, build, and inform their practices, professional training, research, and theoretical productions. Objective To identify and reflect on the possibilities, limits, and challenges of Brazilian occupational therapists' practice in the search for social participation and how this may or may not contribute to the construction of social and occupational justice. Method Through a collaborative methodology, academics, and assistance occupational therapists, working in the state of São Paulo, Brazil, were invited to answer a questionnaire. This instrument characterized the collaborators, and their work in teaching, research, and assistance, and identified how they discuss and carry out social participation in the theoretical and practical fields. Results The 65 collaborators were inserted in public, private and philanthropic institutions, in different fields of knowledge and practice, and developed work and studies with/for various populations with specific demands and needs. They described different possibilities of social participation, some of an individual nature, focused on the subject and functionality, and others oriented towards and from the collective. The limits and challenges were related to work institutions, individual, collective, and structural aspects, and the field of knowledge and practice of occupational therapy. Conclusion Based on the experiences of the collaborators and the professionals' understanding of social participation, it is considered that this may be a theoretical, conceptual, and practical path to reflect on and seek occupational and social justice with individuals, groups, and communities.

https://doi.org/10.1590/2526-8910.ctoao233130811

14.

Morphometric Analyses of the Caroticoclinoid and Interclinoid Foramina: A Study in Brazilian Dry Skulls
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de-Oliveira, Kennedy Martinez

; de-Almeida, Valério Landim

; Benevenuto, Gabriel das Chagas

; de-Faria, Gustavo Maia

; Silva, Ana Clara Camillato e

; Costa, Thayná Cristina Ferreira

; de-Oliveira, Daniel Gonçalves

; Bueno, Leonardo Braga

; Rodrigues, Pedro Lucas

; Peixoto, Marcos Túlio Castro

; Gomes, Talita Cardoso

; Oliveira, Maísa de Fátima Satiro

; Gonçalves, Giuliano Roberto

; Grecco, Leandro Henrique

International Journal of Morphology

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oct 2021, Volume 39 N. 5 Pages 1345 - 1352

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

SUMMARY: The caroticoclinoid (CF) and the interclinoid (IF) foramina are variant formations of the middle cranial fossa, which result from idiopathic and possibly atavistic ossifications of the caroticoclinoid and interclinoid ligaments, respectively. Topographically, these foramina are intimately associated, to varying degrees, depending on their conformations, with the neurovascular elements of the paraclinoid region and have important clinical and surgical significance. Thus, this study, conducted from 38 dry skulls belonging to the shared collection of the Federal University of Juiz de Fora, Governador Valadares campus, revealed 11 skulls (28.95 %) with one of the two complete formations - the caroticoclinoid or the interclinoid, and in 6 skulls the caroticoclinoid foramen occurred uni or bilaterally. As a result, 50 % of these skulls presented the CF exclusively on the right (or 62.5 % of the total number of variant foramina), with an average transverse diameter of 4.91 mm and 5.8 mm AP (anteroposterior) diameter and an average area of 22.5 mm2. Concerning the IF, the findings occurred in 5 skulls with variable distributions between the clinoid processes and lateralities. The average length of the bone bridges in the IF was 7.7 mm. In conclusion, detailed anatomical knowledge of the caroticoclinoid and the interclinoid foramina is fundamental to the practice of neurosurgical procedures, since they have intimate relationships at a location of high structural complexity.

RESUMEN: El foramen caroticoclinoideo (FC) y el foramen interclinoideo (IC) son formaciones variables de la fosa craneal media, que resultan de osificaciones idiopáticas y posiblemente atávicas de los ligamentos caroticoclinoideo e interclinoideo, respectivamente. Estos forámenes están íntimamente asociados topográficamente en diversos grados, dependiendo de sus conformaciones, con los elementos neurovasculares de la región paraclinoidea y tienen importancia clínica y quirúrgica. Así, este estudio, realizado a partir de 38 cráneos secos pertenecientes a la colección compartida de la Universidad Federal de Juiz de Fora, campus Governador Valadares, reveló 11 cráneos (28,95 %) con una de las dos formaciones completas: el FC o el IC, y en 6 cráneos el FC se presentó uni o bilateralmente. Como resultado, el 50 % de estos cráneos presentaba el FC exclusivamente a la derecha (o el 62,5 % del total de forámenes variantes), con un diámetro transversal medio de 4,91 mm y un diámetro anteroposterior medio de 5,8 mm y un área promedio de 22,5 mm2. En cuanto a la FI, los hallazgos se presentaban en 5 cráneos con distribuciones variables entre los procesos clinoides y lateralidades. La longitud media de los puentes óseos en el FI fue de 7,7 mm. En conclusión, el conocimiento anatómico detallado de los forámenes caroticoclinoideo e interclinoideo resulta fundamental para la práctica de procedimientos neuroquirúrgicos, ya que presentan relaciones íntimas en un lugar de alta complejidad estructural.

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15.

[SciELO Preprints] - COVID-Inconfidentes - SARS-CoV-2 seroprevalence in two Brazilian urban areas during the pandemic first wave: study protocol and initial results
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Meireles, Adriana Lucia Lourenção, Luciano Garcia Menezes Junior, Luiz Antônio Alves de Coletro, Hillary Nascimento Justiniano, Irene Carolina Sousa Moura, Samara Silva de Diniz, Amanda Popolino Sabião, Thaís da Silva Rocha, Ana Maria Sampaio Batista, Aline Priscila Lage, Nara Nunes Simões, Bárbara dos Santos Santos, Carolina Ali Mendonça, Raquel de Deus Andrade, Amanda Cristina de Souza Barbosa, Keila Furbino Masioli, Cássio Zumerle Carraro, Júlia Cristina Cardoso Menezes, Mariana Carvalho de Nascimento, Renata Cristina Rezende Macedo Roever, Leonardo Caiaffa, Waleska Teixeira Machado-Coelho, George Luiz Lins

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Publication date: 2021-07-29

Abstract: En

Background: A population study is an important tool that can be used to understand the actual epidemiological scenario of the Covid-19 in different territories, identify its magnitude, understand its transmission dynamics, and its demographic, geographical, and social distribution. Objective: The aim of this study was to determine the prevalence and dynamics of SARS-CoV-2 infection in the population of two Brazilian cities during the pandemic first wave and subsequent socioeconomic and health effects. Materials & methods: This paper described the methodological procedures adopted and the prevalence of the SARS-CoV-2 infection in the population. A household survey was conducted between October and December 2020, in two historic cities of Brazil's mining region. Anti-SARS-CoV-2 antibody was detected using the Wondfo® rapid test. The face-to-face interview consisted of administration of a questionnaire containing registration data, sociodemographic and economic variables, living habits, general health condition, mental health, sleep habits, and eating and nutrition. Results: We evaluated 1,762 residents, of which 764 (43.4%) were in Mariana and 998 (56.6%) in Ouro Preto. For both cities, 51.9% of the interviewees were female, with a predominance of the age range 35 to 59 years old (47.2%). The prevalence of the SARS-CoV-2 infection was 5.5% in all cities, 6.2% in Ouro Preto, and 4.7% in Mariana. The prevalence was similar between cities (P>0.05). Conclusion: The study was effective in verifying the seroprevalence of infection by the virus and its findings will enable further analyses of the health conditions of the population related to social isolation and the risk of infection with SARS-CoV-2.

https://doi.org/10.1590/SciELOPreprints.2720

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