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DIGINVASIVE: Sistema de Alerta y Control de especies invasoras. Caso de estudio: Amaranthus palmeri
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Castro, Ana I. de

; Mesías-Ruiz, Gustavo A.

; Llenes, Josep María

; Borra-Serrano, Irene

; Rueda-Ayala, Christian

; Dorado, José

; Recasens, Jordi

; Peña, José Manuel

Revista de Ciências Agrárias

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mar 2024, Volume 47 N. 1 Pages 371 - 380

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Efficient invasive weed management is critical to maintain the balance between biodiversity, production and agricultural sustainability. Invasive plants may cause significant yield losses in crops and their control entails a high cost in pesticide products, in addition to the ecological damage they generate. Advances in robotics, digital agriculture, artificial intelligence, etc, allow the inputs’ optimization (e.g. pesticides) through timely and site-specific treatments tailored to the real crop needs, aligned with the principles of precision agriculture. Amaranthus palmeri has been recently detected in Spanish crop fields. It is an extremely competitive species, with a high fertility rate and skilled at developing herbicide-resistant biotypes, which poses a serious threat to Spanish agriculture. Therefore, a digital agriculture tool -called DIGINVASIVE- is being designed for mapping and monitoring of A. palmeri in crops, which consists of an open-source web-based interface system using innovative digital technologies such as drone imagery, Geographic Information Systems, Information and Communication Technologies and powerful Artificial Intelligence algorithms. This interactive tool will allow users to establish suitable prevention and eradication measures to address the control of A. palmeri in agricultural environments.

Resumen La gestión eficiente de las malas hierbas invasoras es fundamental para mantener el equilibrio entre biodiversidad, producción y sostenibilidad agrícola. Esto se debe a que las malas hierbas invasoras pueden causar pérdidas significativas de rendimiento en los cultivos y su control supone un elevado coste en productos fitosanitarios, además de los daños ecológicos que generan. Los avances en robótica, digitalización, inteligencia artificial, etc., permiten la optimización de los recursos empleados (e.g. fitosanitarios) mediante la aplicación de tratamientos localizados y ajustados a las necesidades reales del cultivo siguiendo los principios de la agricultura de precisión. Recientemente se ha confirmado la presencia de la planta invasora Amaranthus palmeri en parcelas agrícolas en España. Esta especie es altamente competitiva, presenta una elevada tasa de fecundidad y la capacidad para desarrollar biotipos resistentes a los herbicidas, convirtiéndola en una de las especies exóticas con mayor amenaza para la agricultura española. Para ello, se ha desarrollado una herramienta de agricultura digital -denominada DIGINVASIVE- para el mapeo y seguimiento de A. palmeri en campos agrícolas, consistentes en un servidor de cartografía digital web de código abierto que utiliza tecnologías digitales innovadoras como imágenes de dron, Sistemas de Información Geográfica, Tecnologías de la Información y la Comunicación y potentes algoritmos de Inteligencia Artificial. Esta herramienta interactiva permitirá a los usuarios establecer las medidas de prevención y erradicación necesarias para abordar el control de A. palmeri en escenarios agrícolas.

https://doi.org/10.19084/rca.34978

Estudio correlacional del estrés crónico y sus síntomas psicofisiológicos con el síndrome de intestino irritable en estudiantes de odontología
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Pozos-Radillo, Blanca Elizabeth

; Plascencia-Campos, Ana Rosa

; Preciado-Serrano, María de Lourdes

; García Suarez, Ana Karina

; Acosta-Fernández, Martín

Acta universitaria

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2024, Volume 34 elocation e4059

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen El propósito de este estudio fue analizar la correlación del estrés crónico y sus síntomas psicofisiológicos como predictores del síndrome de intestino irritable en estudiantes de odontología de una universidad pública en México. El estudio fue transversal y analítico. Se evaluó una muestra representativa y aleatoria de 740 estudiantes en el año 2022. Se utilizó el Inventario de Síntomas de Estrés y los Criterios de ROMA III. El análisis fue mediante regresión múltiple. Los resultados mostraron que el estrés crónico y los síntomas físicos (resequedad en la boca e hipertensión) así como los síntomas psicológicos (sentirse atado y tendencia a asustarse con pequeños ruidos) estuvieron asociados y fueron predictores de la presencia del síndrome de intestino irritable. Se concluye que la identificación de los factores de estrés podría incidir en un diagnóstico oportuno y prevenir sus efectos nocivos a la salud y en el rendimiento académico de los estudiantes.

Abstract The purpose of this study was to analyze the correlation of chronic stress and its psychophysiological symptoms as predictors of irritable bowel syndrome in dental students from a public university in Mexico. The study was cross-sectional and analytical. A representative and random sample of 740 students was evaluated in 2022. The Stress Symptom Inventory and the ROME III Criteria were used. The analysis was done through multiple regression. Results showed that chronic stress and physical symptoms (dry mouth and hypertension) as well as psychological symptoms (feeling tied and tendency to be scared by small noises) were associated, and they were predictors of the presence of irritable bowel syndrome. It is concluded that the identification of stress factors could influence a timely diagnosis and prevent their harmful effects on health and on the academic performance of students.

https://doi.org/10.15174/au.2024.4059

FLNC Associada a Cardiomiopatia Restritiva e Hipertrabeculação, uma Associação Rara Hipertrabeculação
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Aristizabal, Ana M.

; Guzmán-Serrano, Carlos Alberto

; Lizcano, María Isabel

; Mosquera, Walter

; Lores, Juliana

; Pachajoa, Harry

; Cely, Cesar

Arquivos Brasileiros de Cardiologia

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2024, Volume 121 N. 5 elocation e20230790

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Menina de seis anos com cardiomiopatia restritiva e hipertrabeculação na qual, devido ao início precoce da doença, foi realizado sequenciamento completo do exoma, revelando a presença de uma nova variante heterozigótica missense no gene FLNC. A mesma variante genética também foi identificada em seu pai, que, já adulto, apresentava resultados de imagem normais e não apresentava sintomas. Esta variante não foi relatada em bancos de dados populacionais ou na literatura médica atual e é classificada como provavelmente patogênica. qual doença exoma FLNC pai que adulto sintomas patogênica

Abstract A six-year-old girl with restrictive cardiomyopathy and hypertrabeculation, due to the early onset of her disease, whole exome sequencing was conducted, revealing the presence of a novel heterozygous missense variant in the FLNC gene. The same gene variant was also identified in her father, who, at an adult age, displayed normal imaging results and was symptom-free. This variant has not been reported in population databases or current medical literature and is classified as likely pathogenic. sixyearold six year old hypertrabeculation disease conducted father who age symptomfree. symptomfree symptom free. free symptom-free pathogenic

https://doi.org/10.36660/abc.20230790

Factors associated with university students’ knowledge about HIV and pre- and post-exposure prophylaxis students pre postexposure post exposure
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Lima, Ana Luísa Serrano

; Sesnik, Heitor Hortensi

; Lima, Lucas Vinícius de

; Pavinati, Gabriel

; Merino, Maria de Fátima Garcia Lopes

; Paiano, Marcelle

; Gil, Nelly Lopes de Moraes

; Magnabosco, Gabriela Tavares

Revista Brasileira de Enfermagem

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2024, Volume 77 Suppl. 2 elocation e20240092

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivos: analisar os fatores associados ao conhecimento de universitários sobre o HIV e as profilaxias pré e pós-exposição. Métodos: estudo transversal realizado com 503 universitários de um estado do sul do Brasil, cujos dados foram coletados por meio de um instrumento de caracterização e um questionário contendo 16 afirmativas sobre o tema; na análise, utilizaram-se medidas descritivas e modelos de regressão de Poisson com variância robusta. Resultados: a prevalência de conhecimento adequado (ou seja, mais de 12 acertos) foi de 27,83%; os universitários com idade superior a 24 anos, dos cursos da área de saúde, que não tiveram relações sexuais no último trimestre, com histórico de teste rápido para HIV e que sabiam ou já tinham ouvido falar sobre as profilaxias apresentaram maior probabilidade de obter mais de 12 acertos. Conclusões: verificou-se que, de modo geral, o conhecimento dos jovens sobre o HIV e suas profilaxias foi inadequado e influenciado por fatores sociodemográficos, educacionais e comportamentais. Objetivos pósexposição. pósexposição pós exposição. exposição pós-exposição Métodos 50 Brasil 1 tema análise utilizaramse utilizaram se robusta Resultados seja acertos 27,83% 2783 27 83 2 anos saúde trimestre Conclusões verificouse verificou geral sociodemográficos comportamentais 5 27,83 278 8 27,8 27,

ABSTRACT Objectives: to analyze the factors associated with university students’ knowledge about HIV and pre- and post-exposure prophylaxis. Methods: a cross-sectional study was conducted with 503 university students from a southern state in Brazil; data were collected using a characterization tool and a questionnaire containing 16 statements about the topic; descriptive measures and Poisson regression models with robust variance were used for analysis. Results: the prevalence of adequate knowledge (i.e., scoring more than 12 correct answers) was 27.83%; students older than 24 years, enrolled in health-related courses, who had not engaged in sexual relations in the last quarter, with a history of rapid HIV testing, and who knew or had heard about the prophylaxes showed a higher likelihood of scoring more than 12 correct answers. Conclusions: generally, the knowledge of young people about HIV and its prophylaxes was found to be inadequate and influenced by sociodemographic, educational, and behavioral factors. Objectives pre postexposure post exposure prophylaxis Methods crosssectional cross sectional 50 Brazil 1 topic analysis Results i.e., ie i e (i.e. answers 27.83% 2783 27 83 2 years healthrelated health related courses quarter testing Conclusions generally sociodemographic educational 5 i.e. (i.e 27.83 278 8 i.e 27.8 27.

RESUMEN Objetivos: analizar los factores asociados con el conocimiento de los estudiantes universitarios sobre el VIH y la profilaxis pre y post exposición. Métodos: se realizó un estudio transversal con 503 estudiantes universitarios de un estado del sur de Brasil; los datos se recopilaron utilizando una herramienta de caracterización y un cuestionario que contenía 16 declaraciones sobre el tema; se utilizaron medidas descriptivas y modelos de regresión de Poisson con varianza robusta para el análisis. Resultados: la prevalencia de conocimiento adecuado (es decir, obtener más de 12 respuestas correctas) fue del 27.83%; los estudiantes mayores de 24 años, matriculados en cursos relacionados con la salud, que no habían tenido relaciones sexuales en el último trimestre, con antecedentes de pruebas rápidas de VIH y que conocían o habían oído hablar sobre las profilaxis mostraron una mayor probabilidad de obtener más de 12 respuestas correctas. Conclusiones: en general, se encontró que el conocimiento de los jóvenes sobre el VIH y sus profilaxis era inadecuado e influenciado por factores sociodemográficos, educativos y conductuales. Objetivos exposición Métodos 50 Brasil 1 tema análisis Resultados es decir correctas 27.83% 2783 27 83 2 años salud trimestre Conclusiones general sociodemográficos conductuales 5 27.83 278 8 27.8 27.

https://doi.org/10.1590/0034-7167-2024-0092

The link between alterations in circadian rhythms and lipid metabolism in bipolar disorder: the hypothesis of lipid droplets disorder
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Pereira, Ana Catarina

; Serrano-Cuñarro, Laura

; Cruz, Maria Teresa

; Cavadas, Cláudia

; Pereira, Cláudia Maria Fragão

Brazilian Journal of Psychiatry

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2024, Volume 46 elocation e20243670

Abstract: En | Text: En | PDF: En

Bipolar disorder (BD) is a neuropsychiatric illness characterized by recurrent episodes of mania and depression, leading to significant cognitive and functional impairments, psychiatric and metabolic comorbidities, and substantial healthcare costs. The complex nature and lack of specific biomarkers for BD make it a daily challenge for clinicians. Therefore, advancing our understanding of BD pathophysiology is essential to identify novel diagnostic biomarkers and potential therapeutic targets. Although its neurobiology remains unclear, circadian disruption and lipid alterations have emerged as key hallmarks of BD. Lipids are essential components of the brain and play a critical role in regulating synaptic activity and neuronal development. Consequently, alterations in brain lipids may contribute to the neuroanatomical changes and reduced neuroplasticity observed in BD. Lipid droplets, which regulate the storage of neutral lipids, buffer the levels of toxic lipids within cells. These dynamic organelles adapt to cellular needs, and their dysregulated accumulation has been implicated in several pathological conditions. Notably, lipid droplets and different classes of lipids exhibit rhythmic oscillations throughout the 24-hour cycle, suggesting a link between lipid metabolism, circadian rhythms, and lipid droplets. In this review, we explore the impairment of circadian rhythms and lipid metabolism in BD and present evidence that circadian clocks regulate lipid droplet accumulation. Importantly, we propose the “hypothesis of lipid droplets for BD,” which posits that impaired lipid metabolism in BD is closely linked to alterations in lipid droplet homeostasis driven by circadian clock disruption. (BD depression impairments comorbidities costs clinicians Therefore targets unclear development Consequently cells needs conditions Notably 24hour hour 24 cycle review Importantly hypothesis BD, 2

https://doi.org/10.47626/1516-4446-2024-3670

Producción de insectos comestibles: retos, oportunidades y perspectivas para Costa Rica
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Bermúdez-Serrano, Ileana Maricruz

; Quirós-Blanco, Ana María

; Acosta-Montoya, Óscar

Agronomía Mesoamericana

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dec 2023, Volume 34 N. 3 elocation 53052

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Introducción. Los insectos comestibles se presentan como una fuente alternativa de proteína generada con prácticas de producción sostenibles con el medio ambiente y de alto valor nutricional. La producción de alimentos con insectos ha aumentado en los últimos años a nivel mundial y se estima que continuará en crecimiento. Costa Rica cuenta con un pequeño número de productores de insectos comestibles, lo que ha conllevado un creciente interés de la academia y entidades estatales por fomentar el sector. Objetivo. Presentar el mercado actual, las oportunidades, los retos y las perspectivas de la producción, procesamiento y comercialización de insectos comestibles a nivel internacional y en Costa Rica. Desarrollo. Se describe el mercado actual de los insectos comestibles a nivel mundial, los principales retos y oportunidades de su producción, procesamiento y comercialización, así como el desarrollo del sector en Costa Rica. Conclusión. A nivel mundial, los principales retos relacionados con la producción de alimentos con insectos son la baja aceptación del consumidor, la falta de tecnologías de producción de insectos y un deficiente marco regulatorio. En Costa Rica, debido a los esfuerzos conjuntos de la academia, el sector público y privado, existe un marco regulatorio base que permite la producción de tres especies de insectos para consumo humano. Los costarricenses tienen la disposición de incluir los insectos en su dieta, pero aún es necesario desarrollar mejores métodos de producción para facilitar el crecimiento del sector.

Abstract Introduction. Edible insects emerge as an alternative source of protein generated with environmentally sustainable production practices and high nutritional value. The production of insect-based food products has increased globally in recent years and it is expected to continue growing. Costa Rica has a small number of edible insect producers, which has led to growing interest from academia and government entities in promoting the sector. Objective. To present the current market, opportunities, challenges, and perspectives of edible insect production, processing, and marketing internationally and in Costa Rica. Development. The current global market for edible insects is described, the main challenges, and opportunities in their production, processing, and marketing, as well as the sector's development in Costa Rica. Conclusion. Globally, key challenges in edible insect production include low consumer acceptance, lack of insect production technologies, and inadequate regulatory framework. In Costa Rica, collaborative efforts from academia, the public, and private sectors have established a basic regulatory framework allowing the production of three insect species for human consumption. Costa Ricans are willing to include insects in their diet, but there is still a need to develop better production methods to facilitate the sector growth.

https://doi.org/10.15517/am.2023.53052

Nivel de desarrollo en población infantil menor de seis años valorada con la prueba de tamizaje EDIN-II en Costa Rica
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Quezada-Ugalde, Ana María

; Valverde-Hernández, Melissa Edith

; González-Serrano, Sunny

Población y Salud en Mesoamérica

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dec 2023, Volume 21 N. 1 Pages 168 - 186

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Introduction: The General Test for the Evaluation of the Integral Development of the Child (EDIN-II) created and validated in Costa Rica, classifies the child population with normal or age-appropriate development (green), with a developmental lag (yellow), or else, with a risk of significant delay (red). However, the results of its application at the population level are not known. Objective: report the level of development of the infants evaluated during the validation processes of the EDIN-II test. Methodology: A secondary analysis of descriptive and correlational scope is carried out; the EDIN-II test was applied by nursing professionals, during the years 2016 - 2020. A total of 438 children aged 1 to 72 months in different zones of the metropolitan area of the country. Results: 78.5 % (n= 344) have an adequate development for their age and 21.5 % (n= 94) present a delay or risk of delay in their development. Conclusions: The prevalence of risk of developmental delay was 21.5%, with a higher proportion between 12 and 36 months of life.

Resumen Introducción: la Prueba General para la Evaluación del Desarrollo Integral de la Niña y el Niño (EDIN-II), creada y validada en Costa Rica, clasifica la población infantil en desarrollo normal o adecuado para su edad (verde); rezago en su desarrollo (amarillo); o bien, riesgo de retraso significativo (rojo). No obstante, los resultados de su aplicación a nivel poblacional son desconocidos. Objetivo: dar a conocer el nivel de desarrollo del grupo de infantes evaluados durante la fase de validación de la prueba EDIN-II. Metodología: se efectuó un análisis secundario de alcance descriptivo y correlacional; la prueba EDIN-II fue aplicada por profesionales de enfermería durante los años 2016 – 2020. Se evaluaron un total de 438 niñas y niños entre 1 y 72 meses de edad, en diferentes zonas del Gran Área Metropolitana del país. Resultados: el 78,5 % (n = 344) presentó un desarrollo adecuado para su edad; el 21,5 % (n= 94), un rezago o riesgo de retraso en su desarrollo. Conclusiones: la prevalencia de riesgo de retraso del desarrollo fue del 21.5 %, con una proporción mayor para el grupo con edades de 12 a 36 meses.

https://doi.org/10.15517/psm.v21i1.53285

Prevalence of Sjögren’s syndrome according to 2016 ACR-EULAR classification criteria in patients with systemic lupus erythematosus Sjögrens Sjögren s 201 ACREULAR ACR EULAR 20 2
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Gianordoli, Ana Paula Espíndula

; Laguardia, Rafaella Vila Real Barbosa

; Santos, Maria Carmen F. S.

; Jorge, Fabiano Cade

; Salomão, Amanda da Silva

; Caser, Larissa Carvalho

; Moulaz, Isac Ribeiro

; Serrano, Érica Vieira

; Miyamoto, Samira Tatiyama

; Machado, Ketty Lysie Libardi Lira

; Valim, Valéria

Advances in Rheumatology

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2023, Volume 63 elocation 11

Abstract: En | Text: En | PDF: En

Abstract Background Diagnosis of SS is a complex task, as no symptom or test is unique to this syndrome. The American-European Consensus Group (AECG 2002) and the American-European classification criteria of 2016 (ACR/EULAR 2016) emerged through a search for consensus. This study aims to assess the prevalence of Sjögren’s Syndrome (SS) in patients with Systemic Lupus Erythematosus (SLE), according to AECG 2002 and ACR-EULAR 2016 classifications, as well as clinical and histopathological features in this overlap. To date, there is no study that has evaluated SS in SLE, using the two current criteria. Methods This cross-sectional study evaluated 237 SLE patients at the outpatient rheumatology clinic between 2016 and 2018. Patients were submitted to a dryness questionnaire, whole unstimulated salivary flow (WUSF), “Ocular Staining Score” (OSS), Schirmer’s test I (ST-I), and labial salivary gland biopsy (LSGB). Results After verifying inclusion and exclusion criteria, a total of 117 patients were evaluated, with predominance of females (94%) and mixed ethnicity (49.6%). The prevalence of SS was 23% according to AECG 2002 and 35% to ACR- EULAR 2016. Kappa agreement between AECG 2002 and ACR-EULAR 2016 were 0.7 (p < 0.0001). After logistic regression, predictors for SS were: anti/Ro (OR = 17.86, p < 0.05), focal lymphocytic sialadenitis (OR = 3.69, p < 0.05), OSS ≥ 5 (OR = 7.50, p < 0.05), ST I positive (OR = 2.67, p < 0.05), and WUSF ≤ 0.1 mL/min (OR = 4.13, p < 0.05). Conclusion The prevalence of SS in SLE was 23% (AECG 2002) and 35% (ACR-EULAR 2016). The presence of glandular dysfunction, focal lymphocytic sialadenitis, and anti/Ro were predictors of SS in SLE. The greatest advantage of the new ACR-EULAR 2016 criteria is to enable an early diagnosis and identify the overlapping of these two diseases. ACR- EULAR 2016 criteria is not yet validated for secondary SS and this study is a pioneer in investigating prevalence based on the new criteria. task syndrome AmericanEuropean American European 201 ACR/EULAR ACREULAR ACR consensus Sjögrens Sjögren s (SS , (SLE) 200 classifications overlap date crosssectional cross sectional 23 2018 questionnaire WUSF, (WUSF) Ocular Score OSS, (OSS) Schirmers Schirmer STI, STI (ST-I) LSGB. LSGB . (LSGB) 11 94% 94 (94% 49.6%. 496 49.6% 49 6 (49.6%) 35 07 0 7 0. 0.0001. 00001 0.0001 0001 0.0001) regression antiRo anti Ro OR 1786 17 86 17.86 0.05, 005 0.05 05 0.05) 369 3 69 3.69 750 50 7.50 267 2 67 2.67 01 1 mLmin mL min 413 4 13 4.13 0.05. dysfunction diseases 20 (SLE (WUSF (OSS (ST-I (LSGB 9 (94 49.6 (49.6% 0000 0.000 000 178 8 17.8 00 0.0 36 3.6 75 7.5 26 2.6 41 4.1 (9 49. (49.6 0.00 17. 3. 7. 2. 4. ( (49. (49 (4

https://doi.org/10.1186/s42358-022-00280-1

O que mudou entre os períodos de pico e de platô durante a primeira onda do SARS-CoV-2? Estudo multicêntrico português em unidades de cuidados intensivos SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV-2 SARS-CoV- SARS-CoV
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Pereira, Rui Antunes

; Sousa, Marta

; Cidade, José Pedro

; Melo, Luís

; Lopes, Diogo

; Ventura, Sara

; Aragão, Irene

; Lima Neto, Raul Miguel de Freitas

; Molinos, Elena

; Marques, Ana

; Cardoso, Nelson

; Marino, Flávio

; Monteiro, Filipa Brás

; Oliveira, Ana Pinho

; Silva, Rogério C

; Real, André Miguel Neto

; Banheiro, Bruno Sarmento

; Reis, Renato

; Adão-Serrano, Maria

; Cracium, Ana

; Valadas, Ana

; Ribeiro, João Miguel

; Póvoa, Pedro

; Tapadinhas, Camila

; Mendes, Vítor

; Coelho, Luís

; Maia, Raquel

; Freitas, Paulo Telles

; Ferreira, Isabel Amorim

; Ramires, Tiago

; Val-Flores, Luís Silva

; Cascão, Mariana

; Alves, Rita

; Rodeia, Simão C

; Barrigoto, Cleide

; Cardiga, Rosa

; Silva, Maria João Ferreira da

; Vale, Bruno

; Fonseca, Tatiana

; Rios, Ana Lúcia

; Camões, João

; Pérez, Danay

; Cabral, Susana

; Ribeiro, Maria Inês

; Mendes, João João

; Gouveia, João

; Fernandes, Susana Mendes

Revista Brasileira de Terapia Intensiva

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dec 2022, Volume 34 N. 4 Pages 433 - 442

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Analisar e comparar as características de pacientes críticos com a COVID-19, a abordagem clínica e os resultados entre os períodos de pico e de platô na primeira onda pandêmica em Portugal. Métodos: Este foi um estudo de coorte multicêntrico ambispectivo, que incluiu pacientes consecutivos com a forma grave da COVID-19 entre março e agosto de 2020 de 16 unidades de terapia intensiva portuguesas. Definiram-se as semanas 10 - 16 e 17 - 34 como os períodos de pico e platô. Resultados: Incluíram-se 541 pacientes adultos com mediana de idade de 65 [57 - 74] anos, a maioria do sexo masculino (71,2%). Não houve diferenças significativas na mediana de idade (p = 0,3), no Simplified Acute Physiology Score II (40 versus 39; p = 0,8), na pressão parcial de oxigênio/fração inspirada de oxigênio (139 versus 136; p = 0,6), na terapia com antibióticos na admissão (57% versus 64%; p = 0,2) ou na mortalidade aos 28 dias (24,4% versus 22,8%; p = 0,7) entre o período de pico e platô. Durante o período de pico, os pacientes tiveram menos comorbidades (1 [0 - 3] versus 2 [0 - 5]; p = 0,002); fizeram mais uso de vasopressores (47% versus 36%; p < 0,001) e ventilação mecânica invasiva na admissão (58,1% versus 49,2%; p < 0,001), e tiveram mais prescrição de hidroxicloroquina (59% versus 10%; p < 0,001), lopinavir/ritonavir (41% versus 10%; p < 0,001) e posição prona (45% versus 36%; p = 0,04). Entretanto, durante o platô, observou-se maior uso de cânulas nasais de alto fluxo (5% versus 16%; p < 0,001) na admissão, remdesivir (0,3% versus 15%; p < 0,001) e corticosteroides (29% versus 52%; p < 0,001), além de menor tempo de internação na unidade de terapia intensiva (12 versus 8 dias; p < 0,001). Conclusão: Houve mudanças significativas nas comorbidades dos pacientes, nos tratamentos da unidade de terapia intensiva e no tempo de internação entre os períodos de pico e platô na primeira onda da COVID-19. Objetivo COVID19, COVID19 COVID 19, 19 Portugal Métodos ambispectivo COVID-1 202 1 portuguesas Definiramse Definiram se 3 Resultados Incluíramse Incluíram 54 6 57 [5 74 anos 71,2%. 712 71,2% . 71 (71,2%) 0,3, 03 0,3 , 0 0,3) 40 (4 39 0,8, 08 0,8 0,8) oxigêniofração fração 139 (13 136 0,6, 06 0,6 0,6) 57% (57 64% 64 0,2 02 24,4% 244 24 4 (24,4 22,8% 228 22 0,7 07 7 ( [ 5 5] 0,002 0002 002 0,002) 47% 47 (47 36% 36 0,001 0001 001 58,1% 581 58 (58,1 49,2% 492 49 0,001, 59% 59 (59 10% lopinavirritonavir lopinavir ritonavir 41% 41 (41 45% 45 (45 0,04. 004 0,04 04 0,04) Entretanto observouse observou 5% (5 16% 0,3% (0,3 15% 15 29% 29 (29 52% 52 12 0,001. Conclusão COVID19. 19. COVID1 COVID- 20 71,2 (71,2% 0, 13 24,4 (24, 22,8 0,00 000 00 58,1 (58, 49,2 0,0 (0, (2 71, (71,2 24, (24 22, 58, (58 49, (0 (71, (71 (7

ABSTRACT Objective: To analyze and compare COVID-19 patient characteristics, clinical management and outcomes between the peak and plateau periods of the first pandemic wave in Portugal. Methods: This was a multicentric ambispective cohort study including consecutive severe COVID-19 patients between March and August 2020 from 16 Portuguese intensive care units. The peak and plateau periods, respectively, weeks 10 - 16 and 17 - 34, were defined. Results: Five hundred forty-one adult patients with a median age of 65 [57 - 74] years, mostly male (71.2%), were included. There were no significant differences in median age (p = 0.3), Simplified Acute Physiology Score II (40 versus 39; p = 0.8), partial arterial oxygen pressure/fraction of inspired oxygen ratio (139 versus 136; p = 0.6), antibiotic therapy (57% versus 64%; p = 0.2) at admission, or 28-day mortality (24.4% versus 22.8%; p = 0.7) between the peak and plateau periods. During the peak period, patients had fewer comorbidities (1 [0 - 3] versus 2 [0 - 5]; p = 0.002) and presented a higher use of vasopressors (47% versus 36%; p < 0.001) and invasive mechanical ventilation (58.1 versus 49.2%; p < 0.001) at admission, prone positioning (45% versus 36%; p = 0.04), and hydroxychloroquine (59% versus 10%; p < 0.001) and lopinavir/ritonavir (41% versus 10%; p < 0.001) prescriptions. However, a greater use of high-flow nasal cannulas (5% versus 16%, p < 0.001) on admission, remdesivir (0.3% versus 15%; p < 0.001) and corticosteroid (29% versus 52%, p < 0.001) therapy, and a shorter ICU length of stay (12 days versus 8, p < 0.001) were observed during the plateau. Conclusion: There were significant changes in patient comorbidities, intensive care unit therapies and length of stay between the peak and plateau periods of the first COVID-19 wave. Objective COVID19 COVID 19 COVID-1 characteristics Portugal Methods 202 1 units respectively 34 defined Results fortyone forty one 6 57 [5 74 years 71.2%, 712 71.2% , 71 (71.2%) included 0.3, 03 0.3 0 3 0.3) 40 (4 39 0.8, 08 0.8 8 0.8) pressurefraction pressure fraction 139 (13 136 0.6, 06 0.6 0.6) 57% (57 64% 64 0.2 02 admission 28day day 28 24.4% 244 24 4 (24.4 22.8% 228 22 0.7 07 7 period ( [ 5 5] 0.002 0002 002 47% 47 (47 36% 36 0.001 0001 001 58.1 581 58 (58. 49.2% 492 49 45% 45 (45 0.04, 004 0.04 04 0.04) 59% 59 (59 10% lopinavirritonavir lopinavir ritonavir 41% 41 (41 prescriptions However highflow high flow 5% (5 16% 0.3% (0.3 15% 15 29% 29 (29 52 52% 12 Conclusion COVID1 COVID- 20 71.2 (71.2% 0. 13 24.4 (24. 22.8 0.00 000 00 58. (58 49.2 0.0 (0. (2 71. (71.2 24. (24 22. 49. (0 (71. (71 (7

https://doi.org/10.5935/0103-507x.20210037-pt

10.

Evaluation of sialic acid concentrations and its association with the use of hormonal contraceptives
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Rodríguez-López, Andrea G.

; Córdova-Serrano, Mónica L.

; González-Bolaños, Ana L.

; Téllez-Blanco, Karen B.

; Marín-Jaureguí, Laura S.

; Santoyo-Treviño, María José

; Hernández-Arteaga, Aida C.

Gaceta mexicana de oncología

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sep 2022, Volume 21 N. 3 Pages 89 - 98

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Objective: To evaluate the relationship between the use of HC and the concentration of Sialic acid (CSA) detected in the saliva of 120 women from San Luís Potosí, Mexico. Methods: Three groups were evaluated control group, HC intake shorter than 4 years, and HC intake longer than 4 years. A questionnaire was applied, anthropometric measures were taken, and collection of saliva samples was carried out. The samples were analyzed with Raman-SERS, for which silver nanoparticles were synthesized, and the measurement of SA was held. Results: The concentrations were divided into three SA groups normal (≤ 4 mg/dL), risk (> 4-7 mg/dL), and altered(> 7 mg/dL). The maximum CSA was detected, which was 9.2 mg/dL. All the volunteers who used the intrauterine system (IUS) and most of the ones who used the pills and subdermal implant (SI) presented risk and altered concentrations. Conclusions: That there is an association between the HC and the CSA, presenting a higher concentration, those volunteers who used IUS, contraceptive pills, and SI.

Resumen Objetivo: Evaluar la relación entre el uso de anticonceptivos hormonales (AH) y las concentraciones de ácido siálico (AS) detectado en saliva de mujeres de San Luis Potosí, México. Métodos: Se formaron tres grupos grupo control, ingesta de AH menor a 4 años e ingesta de AH mayor a 4 años. Se aplicó un cuestionario, se tomaron medidas antropométricas y se llevó a cabo la recolección de muestras de saliva. Las muestras se analizaron con Raman-SERS (surface-enhanced Raman spectroscopy); para lo cual se sintetizaron nanopartículas de plata y se llevó a cabo la medición de concentración de AS, comparando los resultados obtenidos con una curva de calibración. Resultados: Se dividieron en tres grupos las concentraciones de AS normal (≤ 4 mg/dl), riesgo (> 4-7 mg/dl) y alterado (> 7 mg/dl). La concentración máxima de AS detectado fue de 9.2 mg/dl. Todas las voluntarias que utilizan sistema intrauterino (SIU) y la mayoría de las que utilizan píldoras e implante subdérmico (IS), presentaron concentraciones de riesgo y valores de AS alterados. Conclusiones: Existe una asociación entre el uso de AH y las concentraciones de AS, presentando una mayor concentración de AS aquellas voluntarias que utilizan SIU, píldoras anticonceptivas e IS.

https://doi.org/10.24875/j.gamo.22000081 20 downloads

11.

Prevalencia y factores asociados a la hiponatremia en pacientes con nutrición enteral
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Serrano-Valles, Cristina

; Gómez-Hoyos, Emilia

; Ortolá-Buigues, Ana

; Primo-Martín, David

; Jiménez-Sahagún, Rebeca

; García-Calvo, Susana

; López-Gómez, Juan José

; Delgado-García, Esther

; Torres-Torres, Beatriz

; Izaola-Jáuregui, Olatz

; Sánchez-Ibáñez, Marta

; Castro, María Ángeles

; de Luis-Román, Daniel

Nutrición Hospitalaria

Journal Metrics
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aug 2022, Volume 39 N. 4 Pages 723 - 727

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Introducción: la hiponatremia es el trastorno electrolítico más frecuente a nivel hospitalario. En pacientes con nutrición enteral (NE) puede influir en el abordaje terapéutico, así como en la selección del preparado nutricional. Objetivos: describir la prevalencia de la hiponatremia en pacientes con NE y factores asociados. Métodos: estudio retrospectivo de 1651 pacientes no críticos con NE, valorados por el Servicio de Endocrinología y Nutrición desde enero de 2014 hasta enero de 2020. Se recogieron la edad, el sexo, el índice de masa corporal (IMC) (kg/m2), el estado nutricional mediante el cuestionario Mini Nutritional Assessment (MNA), el diagnóstico principal y la presencia de hiponatremia al inicio y durante la NE. Resultados: del total, el 53,9 % fueron hombres, con una mediana de edad de 76,8 [65,7-85,3] años. El diagnóstico principal más frecuente fue la patología neurológica (37,3 %). El 26,1 % de los pacientes presentaron hiponatremia: un 11,0 % al inicio de la NE y el 16,7% durante su administración. La hiponatremia fue más frecuente en aquellos con patología digestiva (28,7 %) e infecciosa (27,65 %). Según el MNA, hasta el 41,1 % presentaron desnutrición y la frecuencia de esta fue estadísticamente superior en los pacientes con que en aquellos sin hiponatremia (76,3 % vs. 55,8 %; p < 0,001). En el análisis multivariante, únicamente la desnutrición se asoció de manera significativa con la presencia de hiponatremia, con una OR de 2,86 [IC 95 %: 1,5-4,88]. Conclusiones: la hiponatremia se detectó en un tercio de los pacientes con NE. Su presencia fue hasta 2 veces más frecuente en los pacientes desnutridos, independientemente de la edad, el sexo, el IMC y la patología basal.

Abstract Introduction: hyponatremia is the most frequent disturbance in hospitalized patients. This situation may influence the therapeutic approach in patients with total enteral tube feeding (TEN). Objective: to study the prevalence of hyponatremia and the clinical factors that are associated with increased risk in a population with TEN. Methods: a retrospective study from January 2014 to January 2020; 1,651 non-critically ill patients receiving TEN were included who were assessed by the Department of Endocrinology and Nutrition. Data collected included sex, age, body mass index (BMI) (kg/m2), and nutritional status by Mini Nutritional Assessment (MNA); main disease diagnosis and development of hyponatremia at onset or during TEN were also included. Results: in all, 53.9 % of the total sample were males aged 76.8 [65.7-85.3] years. Neurological pathology was the most frequent primary diagnosis on admission (37.3 %). We found hyponatremia in 26.1 % —11.0 % at onset and 16.7 % during TEN—. Hyponatremia was more frequent in patients with digestive disease (28.7 %) and infectious disease (27.65 %). According to the MNA questionnaire 41.1 % were malnourished and nutritional status was worse in patients with hyponatremia (76.3 % vs. 55.8 %; p < 0.001). By multivariate analysis, malnutrition was only associated with hyponatremia status; OR, 2.86 [95 % CI: 1.5-4.88]. Conclusions: in this study, hyponatremia was detected in a third of patients. This was up to two more times as common in malnourished patients; however, age, sex, BMI, and baseline pathology were not related.

https://doi.org/10.20960/nh.03964

12.

Safety and Revisit Related to Discharge the Sixty-one Spanish Emergency Department Medical Centers Without Hospitalization in Patients with COVID-19 Pneumonia. A Prospective Cohort Study UMC-Pneumonia COVID-19
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Jacob, Javier

; Albert-Casado, Arantxa

; Castillo, Juan G. Del

; Llorens-Soriano, Pere

; Jiménez-Hernández, Sonia

; Burillo-Putze, Guillermo

; Martín-Martínez, Alfonso

; Martín-Sánchez, Francisco J.

; García-Lamberechts, Eric J.

; Piñera-Salmerón, Pascual

; Alquézar-Arbé, Aitor

; Ferre-Losa, Carles

; Juan-Gómez, María Á.

; Serrano-Lázaro, Leticia

; Noceda-Bermejo, José

; Salido-Mota, Manuel

; Fortuny-Bayarri, María J.

; González-Tejera, Matilde

; Ferreras-Amez, José M.

; Díaz-Fernández, Elena

; Quero-Motto, Eva

; Peiró-Gómez, Ana

; Martín-Mojarro, Enrique

; Llopis-Roca, Ferran

; Huerta-García, Arturo

; Pedraza-García, Jorge

; Meléndez-Cálix, Napoleón

; Brazó-Aznar, José V.

; Cano-Cano, María J.

; Miró, Óscar

Revista de investigación clínica

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jun 2022, Volume 74 N. 3 Pages 135 - 146

Abstract: En | Text: En | PDF: En

ABSTRACT Background: Information is needed on the safety and efficacy of direct discharge from the emergency department (ED) of patients with COVID-19 pneumonia. Objectives: The objectives of the study were to study the variables associated with discharge from the ED in patients presenting with COVID-19 pneumonia, and study ED revisits related to COVID-19 at 30 days (EDR30d). Methods: Multicenter study of the SIESTA cohort including 1198 randomly selected COVID patients in 61 EDs of Spanish medical centers from March 1, 2020, to April 30, 2020. We collected baseline and related characteristics of the acute episode and calculated the adjusted odds ratios (aOR) for ED discharge. In addition, we analyzed the variables related to EDR30d in discharged patients. Results: We analyzed 859 patients presenting with COVID-19 pneumonia, 84 (9.8%) of whom were discharged from the ED. The variables independently associated with discharge were being a woman (aOR 1.890; 95%CI 1.176-3.037), age < 60 years (aOR 2.324; 95%CI 1.353-3.990), and lymphocyte count > 1200/mm3 (aOR 4.667; 95%CI 1.045-20.839). The EDR30d of the ED discharged group was 40.0%, being lower in women (aOR 0.368; 95%CI 0.142-0.953). A total of 130 hospitalized patients died (16.8%) as did two in the group discharged from the ED (2.4%) (OR 0.121; 95%CI 0.029-0.498). Conclusion: Discharge from the ED in patients with COVID-19 pneumonia was infrequent and was associated with few variables of the episode. The EDR30d was high, albeit with a low mortality.

https://doi.org/10.24875/ric.22000021 8 downloads

13.

Estrategias de afrontamiento ante el estrés de estudiantes de medicina de una universidad pública en México
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Pozos-Radillo, Blanca Elizabeth

; Preciado-Serrano, María de Lourdes

; Plascencia-Campos, Ana Rosa

; Acosta-Fernández, Martín

; Aguilera Velasco, María de los Ángeles

Investigación en educación médica

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mar 2022, Volume 11 N. 41 Pages 18 - 25

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Introduction: The level of demand during the academic training of medical students is very high and when they do not have adequate coping strategies, it is very likely that their academic performance and health will be affected by exposure to chronic stress situations. Objective: Identify coping strategies related to chronic stress and compare the data between male and female medical students from a public university in Mexico. Method: Observational and cross-sectional study with the participation of 873 medical students in 2018 from a public university. Nowack’s Stress Symptom Inventory and Stress Profile were used. The data were analyzed with the multiple regression statistic and compared between men and women. Results: The regression model statistically validated that the coping styles: positive assessment, minimization of threat and negative assessment (R2 = 0.51; F = 232.71; p < 0.01) were predictors of chronic stress in this sample. The comparative analysis showed a significant difference, in coping strategies as well as in chronic stress and the highest level was in women. And the highest level was in women. Conclusions: Female medical students show a higher risk for chronic stress and non-adaptive coping styles such as negative judgments, minimization of threat and few positive evaluations compared to men, which could lead to damage to their health and academic performance.

Resumen Introducción: El nivel de exigencia durante la formación académica de estudiantes de medicina es muy alto y cuando estos no cuentan con estrategias de afrontamiento adecuadas, es muy probable que su desempeño académico y su salud se vean afectados por causa de la exposición a situaciones de estrés crónico. Objetivo: Identificar las estrategias de afrontamiento relacionadas con el estrés crónico y comparar los datos entre hombres y mujeres estudiantes de medicina de una universidad pública en México. Método: Estudio observacional y transversal, en 2018, con la participación de 873 estudiantes de medicina de una universidad pública. Se empleó el Inventario de Síntomas de Estrés y el Perfil de Estrés de Nowack. Los datos se analizaron con el estadístico de regresión múltiple y se comparó entre hombres y mujeres. Resultados: El modelo de regresión validó estadísticamente que los estilos de afrontamiento: valoración positiva, minimización de la amenaza y la valoración negativa (R2 = 0.51; F = 232.71; p < 0.01) se relacionaron con el estrés crónico en esta muestra. El análisis comparativo mostró nivel más alto de estrés crónico en mujeres. Conclusiones: Las mujeres estudiantes de medicina muestran mayor riesgo para el estrés crónico y estilos de afrontamiento no adaptativos como juicios negativos, minimización de la amenaza y pocas valoraciones positivas en comparación con los hombres, lo que podría traer como consecuencia daños a su salud y a su desempeño académico.

https://doi.org/10.22201/fm.20075057e.2022.41.21379 448 downloads

14.

Vivencias del paciente ante el diagnóstico de enfermedad renal crónica y su ingreso a diálisis peritoneal
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Rodríguez-Zamora, María Cristina

; Moreno-Serrano, Ana Patricia

; Cabrera-Delgado, Ana Miriam

; Regalado-Ruiz, Luis Alberto

; Amato, Dante

Enfermería Nefrológica

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mar 2022, Volume 25 N. 1 Pages 59 - 65

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT Introduction: A significant number of patients starting on peritoneal dialysis are simultaneously told that they have end-stage chronic kidney disease and require peritoneal dialysis. For many patients the news is unexpected and heartbreaking, as they have to access dialysis in order to stay alive. Method: Qualitative, descriptive study with a phenomenological approach. Of the 106 patients who were admitted to the outpatient peritoneal dialysis program, and who were asked for informed consent to answer the (Coping Inventory Strategies) instrument, 14 patients were selected who expressed their experiences regarding the diagnosis of chronic kidney disease and the urgent need for peritoneal dialysis. They were asked to write in one page how they coped with the news of chronic renal failure and the need for peritoneal dialysis. Results: The mean age was 58.3 years, 66% female and 34% male. Three categories and seven subcategories were identified: socio-occupational (social stigma and uncertainty about the work situation); attitude to death (resignation and guilt) and family support (decision-making, motivation and support). The highest number of patients fell into the category of attitude to death and the subcategory of resignation as a coping strategy. Conclusions: Patients described the phase when they learned of their diagnosis and admission to peritoneal dialysis as the most difficult and traumatic time, expressed feelings of distress, personal or social limitations and confessed dependence on family support.

RESUMEN Introducción: Un número importante de pacientes que ingresan al programa de diálisis peritoneal reciben simultáneamente la noticia de que tienen enfermedad renal crónica en etapa terminal y requieren diálisis peritoneal. Para muchos de ellos la noticia es inesperada y desconsoladora, ya que tienen que acceder a la diálisis para poder seguir viviendo. Material y Método: Estudio cualitativo, descriptivo con enfoque fenomenológico. De 106 pacientes incidentes del programa de diálisis peritoneal ambulatoria a quienes se les solicitó consentimiento informado para contestar el instrumento (Coping Inventory Strategies), se seleccionaron 14 pacientes que relataron sus vivencias respecto a su diagnóstico de enfermedad renal crónica y la necesidad urgente de diálisis peritoneal. Se les pidió que escribieran en una cuartilla cómo enfrentaron la noticia de insuficiencia renal crónica y requerir diálisis peritoneal. Resultados: Se incluyeron en el estudio a 14 pacientes, con edad comprendida entre 41 y 61 años, y el 66% fueron mujeres. Se identificaron tres categorías y siete subcategorías: sociolaboral (estigma social e incertidumbre por el trabajo); actitud ante la muerte (resignación y sentimiento de culpa) y acompañamiento familiar (toma de decisiones, motivación y apoyo). El mayor número de pacientes se ubicó en la categoría de actitud ante la muerte y en la subcategoría de resignación como estrategia de afrontamiento. Conclusiones: Los pacientes describieron la fase en la que se enteraron de su diagnóstico y el ingreso a diálisis peritoneal como el momento más difícil y traumático, manifestaron sentimientos de angustia, limitaciones personales o sociales y reconocieron la dependencia del apoyo familiar.

https://doi.org/10.37551/s2254-28842022007

15.

Disfunción sexual en mujeres con esclerosis sistémica
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Dalpiaz, Marina Soledad

; Argüello, Juan Manuel

; Rodríguez, María Florencia

; Mamani, Marta Norma

; Secco, Anastasia

; Tamborenea, María Natalia

; Kerzberg, Eduardo Mario

; Montoya, Sandra Fabiana

; Aimo, Carolina

; Villalobos, Fernando Manuel

; Serrano, Eliana Rebeca

; Crespo Espíndola, María Elena

; Gervilla Galán, Ana Lía

; Flores, Andrea Marisol

Revista argentina de reumatología

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mar 2022, Volume 33 N. 1 Pages 26 - 34

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Introducción: la disfunción sexual (DS) es común entre las mujeres con enfermedades crónicas, incluyendo esclerosis sistémica (ES). Se ha asociado con características como la duración de la enfermedad, dolor, disminución de la actividad funcional, entre otras. Desde nuestro conocimiento, aún no contamos con datos locales. Objetivos: evaluar la frecuencia de DS en mujeres con ES; describir las características sociodemográficas, clínicas y psicológicas asociadas con la DS en mujeres con ES. Materiales y métodos: estudio observacional, analítico y de corte transversal. Se incluyeron mujeres de entre 20 y 59 años con diagnóstico de ES, según los criterios de clasificación del European League Against Rheumatism/American College of Rheumatology (ACR/EULAR 2013). Se excluyeron pacientes con enfermedades crónicas no controladas, otras patologías reumatológicas autoinmunes, e inactividad sexual o patología genitourinaria no relacionadas a ES en las últimas 4 semanas. La DS se evaluó con la versión en español del cuestionario índice de función sexual femenina (Female sexual function index, FSFI). Resultados: se incluyeron 56 pacientes. El 78,57% presentó DS y 19,64% era sexualmente inactiva debido a la enfermedad. Escala visual análoga (EVA) de fatiga (coeficiente β: -0,08, IC 95%: -0,14 a -0,02; p<0,01), edad (coeficiente β: -0,23, IC 95%: -0,40 a -0,05; p=0,01) y fibromialgia (coeficiente β: -11,90, IC 95%: -17,98 a -5,82; p<0,01) mostraron una asociación significativa e independiente con DS en el análisis multivariado. Conclusiones: la DS es frecuente entre las mujeres con ES, y las pacientes más jóvenes, sin fibromialgia y con menor fatiga presentaron una mejor funcionalidad sexual.

Abstract Introduction: sexual impairment (SI) is common among women with chronic diseases, including systemic sclerosis (SSc). It has been associated with characteristics such as the duration of the disease, pain, decreased functional activity, among others. To the best of our knowledge, we still do not have local data. Objectives: to evaluate the frequency of SI in women with SSc. To describe the sociodemographic characteristics, disease itself and psychological items associated with SI in women with SSc. Materials and methods: observational, analytical, cross-sectional study. We included women between 20 and 59 years diagnosed with SSc according to 2013 classification criteria ACR/EULAR. We excluded patients with uncontrolled chronic diseases or other autoimmune rheumatologic diseases and patients who, in the last 4 weeks, had dyspareunia or were sexually inactive due to causes not attributable to their disease. SI was assessed using the Spanish version of female sexual function index questionnaire (FSFI). Results: 56 patients were included. 78.57% presented SI and 19.64% of them were sexually inactive patients due to the disease. Fatigue VAS (β coefficient: -0.08, CI 95%: -0.14 to -0.02; p<0.01), age (β coefficient: -0.23, CI 95%: -0.40 to -0.05; p=0.01) and fibromyalgia (β coefficient: -11.90, CI 95%: -17.98 to -5.82; p<0.01) showed significant and independent association with SI in the multivariate analysis. Conclusions: SI is frequent among women with SSc, and younger patients, without fibromyalgia and with less fatigue have better sexual function.

https://doi.org/10.47196/rar.v33i1.605 58 downloads

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