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Abstract Background Pyoderma Gangrenosum (PG) is a chronic disease characterized by recalcitrant skin ulcers. Objective We aimed to evaluate the demographic, clinical characteristics, treatments and factors affecting the treatment responses of patients with PG. Methods We performed a multicenter study of 12 tertiary care centers. We analyzed the data of the patients who were followed up with a diagnosis of PG between the years 2012‒2022 retrospectively. Results We included a total of 239 patients of whom 143 were female and 96 were male, with an average age of 54.2 ± 17.4 years. The most common treatment was systemic steroids (n = 181, 75.7%). Among these patients, 50.8% (n = 92) used systemic steroids as the sole systemic agent, while 49.2% (n = 89) used at least one adjuvant immunosuppressive agent. The independent factors determined in regression analysis to influence response to systemic steroids positively were disease onset age ≥ 30-years, negative pathergy, absence of leukocytosis, negative wound culture, presence of a single lesion, and absence of upper extremity involvement. Biological agents were used in 18.4% (n = 44) of the patients in the present study. We also analyzed pathergy positive PG and early onset (onset age < 30) PG separately due to their distinct clinical features which were revealed during statistical analysis. Study limitations Retrospective nature of the present study. Conclusions Analyses of the factors influencing treatment responses are addressed in this study. Also, we concluded that investigation for accompanying autoinflammatory diseases of pathergy positive PG and early onset PG is necessary and the patients in these two groups are more resistant to treatment, necessitating more complicated treatments. (PG ulcers demographic characteristics 1 centers 20122022 2012 2022 2012‒202 retrospectively 23 14 9 male 542 54 2 54. 174 17 4 17. n 181 75.7%. 757 75.7% . 75 7 75.7%) 508 50 8 50.8 92 agent 492 49 49.2 89 30years, 30years 30 years, 30-years leukocytosis culture lesion involvement 184 18 18.4 44 Also 2012202 201 202 2012‒20 5 75.7 50. 49. 3 18. 201220 20 2012‒2 75. 20122 2012‒

Abstract Objectives: multi-system ınflammatory syndrome in children (MIS-C) is an immune-mediated process that develops after infections like SARS-CoV-2. The authors aimed to reveal the mucocutaneous findings of patients diagnosed with MIS-C at presentation and evaluate the frequency of these mucocutaneous findings and their possible relationship with the severity of the disease. Methods: A prospective study was conducted of 43 children admitted to a tertiary hospitals between January 2021 and January 2022 who met Centers for Disease Control and Prevention criteria for MIS-C. Results: 43 children (25 [58.1%] male); median age, 7.5 years [range 0.5-15 years]) met the criteria for MIS-C. The most common symptom was cutaneous rash 81.4%, followed by gastrointestinal symptoms 67.4%, oral mucosal changes 65.1%, and conjunctival hyperemia 58.1%. The most common mucosal finding was fissured lips at 27.9%, diffuse hyperemia of the oral mucosa at 18.6%, and strawberry tongue at 13.9%. Urticaria (48.8%) was the most common type of cutaneous rash in the present study’s patients. The most common rash initiation sites were the trunk (32.6%) and the palmoplantar region (20.9%). The presence or absence of mucocutaneous findings was not significantly associated with disease severity. Study limitations: The number of patients in the this study was small. Conclusions: The present study’s prospective analysis detected mucocutaneous symptoms in almost 9 out of 10 patients in children diagnosed with MIS-C. Due to the prospective character of the present research, the authors think that the characteristic features of cutaneous and mucosal lesions the authors obtained will contribute to the literature on the diagnosis and prognosis of MIS-C. Objectives multisystem multi system MISC MIS C (MIS-C immunemediated immune mediated SARSCoV2. SARSCoV2 SARSCoV SARS CoV 2. 2 SARS-CoV-2 Methods 4 202 MISC. C. Results 25 (2 58.1% 581 58 1 [58.1% male male) age 75 7 5 7. range 0.515 0515 0.5 15 0 0.5-1 years] 814 81 81.4% 674 67 67.4% 651 65 65.1% 279 27 27.9% 186 18 6 18.6% 139 13 13.9% 48.8% 488 48 8 (48.8% studys s 32.6% 326 32 (32.6% 20.9%. 209 20.9% . 20 (20.9%) limitations small Conclusions research SARS-CoV- ( 58.1 [58.1 515 0.51 051 05 0. 0.5- 81.4 67.4 65.1 27.9 18.6 13.9 48.8 (48.8 32.6 3 (32.6 20.9 (20.9% SARS-CoV 58. [58. 51 81. 67. 65. 27. 18. 13. 48. (48. 32. (32. 20. (20.9 [58 (48 (32 (20. [5 (4 (3 (20 [

Index code	Element
ti	article title
au	author
kw	article keywords
subject	subject (title words, abstract and keywords)
ab	abstract
ta	journal short title (e.g. Cad. Saúde Pública)
journal_title	journal full title (e.g. Cadernos de Saúde Pública)
la	publication language code (e.g. pt - Portuguese, es - Spanish)
type	document type
pid	publication identifier
publication_year	publication year of publication
sponsor	sponsor
aff_country	country code of the author's affiliation
aff_institution	author affiliation institution
volume	article volume
issue	article issue
elocation	elocation
doi	DOI number
issn	journal ISSN
in	SciELO colection code (e.g. scl - Brasil, col - Colômbia)
use_license	article usage license code

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