RESUMO Objetivo: Revisar casos de malignidades da cavidade oral disponíveis na literatura em receptores de transplantes renais. Métodos: Foi realizada uma pesquisa no banco de dados PubMed usando os termos “oral cancer”, “mouth neoplasms”, “renal transplantation” e “kidney transplantation”. Independentemente da data de publicação, as publicações foram escolhidas por dois pesquisadores após considerarem cuidadosamente os títulos e resumos e lerem cada artigo em sua totalidade. Resultados: Foram encontrados 12 artigos com casos de malignidades orais em receptores de transplantes renais. No total, 31 neoplasias malignas foram diagnosticadas na cavidade oral, das quais 64,5% (20/31) eram carcinomas espinocelulares; o sarcoma de Kaposi representou 12,9% (4/31) dos casos. Lábios e língua foram os locais mais afetados mencionados mais frequentemente nos artigos avaliados. O tempo pós-transplante variou de 8 meses a 23 anos, e vários imunossupressores foram utilizados. Conclusão: Os receptores de transplante renal devem ser encaminhados regularmente a dentistas e outros profissionais médicos que trabalham no diagnóstico de lesões malignas da cavidade oral a serem avaliadas, e novos casos de câncer oral poderão ser reconhecidos precocemente para tratamento. Esta estratégia poderá melhorar a sobrevivência dos pacientes com esta doença ameaçadora. Objetivo renais Métodos cancer, cancer , cancer” mouth neoplasms, neoplasms neoplasms” transplantation kidney transplantation. . publicação totalidade Resultados 1 total 3 645 64 5 64,5 20/31 2031 20 (20/31 espinocelulares 129 9 12,9 4/31 431 4 (4/31 avaliados póstransplante pós 2 anos utilizados Conclusão avaliadas tratamento ameaçadora 6 64, 20/3 203 (20/3 12, 4/3 43 (4/3 20/ (20/ 4/ (4/ (20 (4 (2 (

ABSTRACT Objective: To review cases of oral cavity malignancies available in the literature in kidney transplant recipients. Methods: A search was carried out in the PubMed database using the terms “oral cancer,” “mouth neoplasms,” “renal transplantation,” and “kidney transplantation.” Regardless of the publication date, the publications were chosen by two researchers after they carefully considered the titles and abstracts and read each article in its entirety. Results: Twelve articles were found with cases of oral malignancies in kidney transplant recipients. In all, 31 malignant neoplasms were diagnosed in the oral cavity, of which 64.5% (20/31) were squamous cell carcinomas; Kaposi's sarcoma represented 12.9% (4/31) of the cases. Lips and tongue were the most affected sites mentioned most frequently in the articles evaluated. Post-transplantation time ranged from 8 months to 23 years, and several immunosuppressants were used. Conclusion: Kidney transplant recipients should be regularly forwarded to dentists and other medical professionals who work in diagnosing malignant lesions of the oral cavity to be evaluated, and new cases of oral cancer can be recognized early to treatment. This strategy could improve the survival of patients with this threatening disease. Objective Methods cancer, mouth neoplasms, renal transplantation, transplantation transplantation. date entirety Results all 3 645 64 5 64.5 20/31 2031 20 (20/31 carcinomas Kaposis Kaposi s 129 12 9 12.9 4/31 431 4 (4/31 evaluated Posttransplantation Post 2 years used Conclusion treatment disease 6 64. 20/3 203 (20/3 1 12. 4/3 43 (4/3 20/ (20/ 4/ (4/ (20 (4 (2 (

Abstract Asymptomatic Apical Periodontitis is essentially an inflammatory disease of microbial aetiology. Association and function of the cell components involved, or specific inductive factors and growth mediators associated with development, maintenance and resolution of the periapical lesions are still unknown. The objective of this study was to evaluate the concentration of Regulatory T cells (FoxP3+; Treg), Langerhans cells (CD1a+; LC) and mast cells in asymptomatic apical periodontitis. 73 cases were selected: 30 periapical granulomas, 29 radicular cysts and 14 residual cysts. All groups were submitted to morphological analysis for classification of inflammatory infiltrate and thickness of the epithelial lining as well as to immunohistochemical analysis for detection of LC and Treg cells. Toluidine blue staining was used for detecting mast cells. Analysis showed higher mean numbers of LC (8.2 cells/0.2mm2), and Treg cells in radicular cysts (5.910 cells/0.2mm2). As for mast cells, it was found that radicular cysts had a higher mean number of these cells compared to other periapical lesions (12.68 cells/0.2mm2). The association between thickness of the epithelial lining and inflammatory cells showed that the presence of hypertrophic epithelium in radicular cysts presented higher density of LC. The number of LC and Treg cells play an important role in the control of the inflammatory micro-environment in periapical granulomas and radicular cysts, respectively. The presence of mast cells in radicular cysts may be associated with progression of the lesion. Knowledge regarding the inflammatory cell profile is therefore essential for a better understanding of the pathogenesis of asymptomatic periapical periodontitis.

Abstract Objectives: This study aimed to verify the presence of polyomavirus BK (BKPyV) in the saliva of kidney transplant recipients and to correlate it with blood viremia. Material and Methods: We have conducted a cross-sectional study with a sample involving 126 renal transplant recipients. 126 samples of saliva and 52 samples of blood were collected from these patients. Detection and quantification of BKPyV were performed using a real-time PCR. To compare the presence of BKPyV in blood and saliva, the binomial proportion test was used. To verify associations between salivary shedding BKPyV and post-transplant periods (in months), the Mann-Whitney test was used. Spearman's correlation was used to correlate the viral load in the saliva with blood of kidney transplant recipients. Results: The mean age of the study group was 51.11±12.45 years old, and 69 participants (54.8%) were female, with a mean post-transplantation time of 4.80±6.04 months. BKPyV was quantified in several samples of saliva and blood, with medians of 1,108 cp/mL and 1,255 cp/mL, respectively. Only 16/52 (30.8%) participants presented BKPyV in blood, and 59/126 (46.8%) excreted the virus in saliva (p=0.004). BKPyV shedding was found in patients at a shorter post-transplantation period (3.86±5.25, p=0.100). A weak correlation was observed between viral quantification in saliva and blood (Spearman's correlation coefficient=0.193). Conclusion: The results of this study suggested that, although saliva excretes more BKPyV than blood, there is no reliable correlation between salivary shedding and blood viremia, showing two independent compartments of viral replication.

Resumo O objetivo foi determinar a prevalência de queilite actínica entre os trabalhadores extrativistas minerais e os fatores associados a esta lesão, principalmente a relação da aparência clínica da lesão com o tempo de exposição ocupacional à luz solar. Foi realizado um estudo transversal, entre 2014 e 2015, em Dona Inês / PB, localizado no Nordeste do Brasil. Foram aplicados um exame clínico, registro fotográfico e um questionário a 201 trabalhadores extrativistas minerais. Realizaram-se os testes “t” student, ANOVA, Exato de Fisher e Qui-quadrado de Pearson, o nível de significância foi de 5%. Observou-se alta prevalência de queilite actínica (38,8%). A duração da exposição ocupacional à luz solar, em meses, (169,63 ± 112,68, p = 0,002) foi associada à presença de queilite actínica. Estes trabalhadores eram, em sua maioria, brancos (p<0.001) com idade média de 37.41±12.15 anos (p=0.004). O tempo de exposição ocupacional à luz solar foi significativo em relação às seguintes características clínicas: atrofia (225,75 ± 97,31; p = 0,024); perda da demarcação entre o vermelhão do lábio e a borda da pele (186,68 ± 113,15; p = 0,032); Fissuras verticais (210,09 ± 123,07; p = 0,046); Manchas brancas e vermelhas (199,51 ± 91,80; p = 0,004); Consistência dura do lábio (225,81 ± 122,34; p = 0,012). Conclui-se que a prevalência de queilite actínica foi alta. A idade e a etnia foram fatores associados a presença de queilite actinica. Os participantes que haviam trabalhado pelo menos 185 meses (aproximadamente 15 anos) sob exposição ao sol, apresentaram manifestações clínicas graves da queilite actínica.

Abstract The objective of the present study was to determine the prevalence of actinic cheilitis among extractive mining workers and factors associated with the condition, especially the relationship between clinical appearance and the length of occupational exposure to sunlight. A cross-sectional study was performed in Dona Inês, Paraíba, Brazil between 2014 and 2015. A clinical examination, clinical photography and a questionnaire were applied to 201 extractive mining workers. The T-student’s, ANOVA one-way, Fisher’s exact and Pearson chi-squared tests were performed and the significance level was set at 5%. A high prevalence of actinic cheilitis was observed (38.8%). Length of occupational exposure to sunlight in months (169.63±112.68, p=0.002) was associated with actinic cheilitis. Most workers were Caucasian (p<0.001) and aged 37.41±12.15 years (p=0.004). The time of occupational exposure to sunlight was significant in relation to the following clinical features: atrophy (225.75±97.31; p=0.024); blurred demarcation between the vermilion border of the lip and the skin (186.68±113.15; p=0.032); vertical fissures (210.09±123.07; p=0.046); white and red spotting (199.51±91.80; p=0.004); hard consistency of the lip (225.81±122.34; p=0.012). A high prevalence of actinic cheilitis was found. Age and ethnicity were associated with the presence of AC. Severe clinical presentations of actinic cheilitis were found among participants who had worked for at least 185 months (approximately 15 years) exposed to the sun.

RESUMO Objetivo: o objetivo do presente estudo foi avaliar a necessidade normativa de tratamento ortodôntico e a percepção dessa necessidade entre alunos de 11-14 anos de idade. Métodos: realizou-se um estudo transversal com uma amostra de 346 alunos selecionados aleatoriamente de escolas públicas e privadas. O Índice de Estética Dental (DAI) foi utilizado para avaliar a necessidade normativa de tratamento ortodôntico (NNTO). A percepção da necessidade de tratamento entre os estudantes foi avaliada por meio de um questionário previamente validado. Os dados foram analisados pelo teste qui-quadrado de Pearson (α = 5%). Resultados: a prevalência de má oclusão e NNTO foi de 65,6%. Da amostra, 73,7% relataram que precisavam de tratamento, 66,2% queriam tratamento ortodôntico e 62,7% estavam satisfeitos com sua estética dentária. Observou-se associação estatisticamente significativa entre o NNTO e a percepção da necessidade de tratamento entre os alunos (p < 0,001). Conclusão: o presente estudo demonstrou alta prevalência de má oclusão, o que se refletiu na alta necessidade normativa de tratamento ortodôntico. A opinião dos pacientes sobre suas expectativas de tratamento ortodôntico deve ser valorizada. Os alunos perceberam a necessidade de tratamento ortodôntico.

ABSTRACT Objective: The aim of the present study was to evaluate the normative need for orthodontic treatment and the perception of such need among students aged 11-14 years. Methods: A cross-sectional study was conducted with a sample of 346 students, randomly selected from public and private schools. The Dental Aesthetic Index (DAI) was used to evaluate the normative need for orthodontic treatment (NNOT). The perceived need for treatment among students was assessed by a previously validated questionnaire. Data was analyzed by Pearson’s Chi-squared test (α = 5%). Results: The prevalence of malocclusion and NNOT was 65.6%. Of the sample, 73.7% felt they needed treatment, 66.2% wanted orthodontic treatment and 62.7% were satisfied with their dental aesthetics. A statistically significant association was observed between NNOT and the perception of the need for treatment among the students (p < 0.001). Conclusion: The present study demonstrated a high prevalence of malocclusion, which was reflected in the high normative need for orthodontic treatment. The opinion of patients regarding their expectations of orthodontic treatment should be valued. The students perceived a need for orthodontic treatment.

Abstract: We report a 35-year-old mulatto female patient with neurofibromatosis Type 1 who presented with facial asymmetry. The patient had two lesions: florid cemento-osseous dysplasia associated with peripheral giant cell granuloma. She was referred for surgical treatment of the peripheral giant cell granuloma and the florid cemento-osseous dysplasia was treated conservatively by a multidisciplinary team. So far, no changes have been observed in the patient's clinical status. We observed no recurrence of peripheral giant cell granuloma. To the best of our knowledge, the present case is the first report of a patient with neurofibromatosis Type 1 associated with a giant cell lesion and florid cemento-osseous dysplasia.

RESUMO Objetivo Avaliar o perfil clínico-patológico de pacientes com neoplasias de glândula salivar menor. Métodos Foi realizado um estudo retrospectivo de casos específicos diagnosticados como neoplasias benignas ou malignas de glândula salivar menor. Os dados foram coletados dos prontuários dos pacientes atendidos em um hospital no período de 15 anos. A amostra final foi de 37 casos. Para o estudo histopatológico, foram usadas lâminas contendo secções com 5μm de espessura, coradas pela técnica de hematoxilina e eosina. Os dados foram tabulados de forma descritiva. Resultados As neoplasias malignas representaram 70,3% dos casos. O tipo histológico mais prevalente foi o carcinoma mucoepidermoide (45,9%), seguido do adenoma pleomórfico (24,4%). A maioria dos pacientes era do sexo feminino (70,3%), com idade entre 71 e 80 anos. O palato (67,6%) e a região retromolar (10,8%) foram os sítios mais acometidos. Conclusão O carcinoma mucoepidermoide foi o tumor mais comum das glândulas salivares menores. Estes tumores foram mais comuns em mulheres com mais de 40 anos. O palato foi o sítio mais acometido.

ABSTRACT Objective To evaluate the clinical-pathological profile of patients with minor salivary gland neoplasms. Methods A retrospective study of specific cases diagnosed as benign and malignant tumors of the minor salivary glands was performed. The data were collected from medical records of patients seen at a hospital over a period of 15 years. The sample was made up of 37 cases. For the pathological study, slides containing 5μm thick sections stained with hematoxylin and eosin were used. The data were tabulated using descriptive statistics. Results Malignant neoplasms represented 70.3% of cases. The mucoepidermoid carcinoma was the most common neoplasm (45.9%), followed by pleomorphic adenoma (24.4%). Most patients were female (70.3%), aged between 71 and 80 years. The palate (67.6%) and the retromolar region (10.8%) were the most affected sites. Conclusion Mucoepidermoid carcinoma was the most common tumor in minor salivary glands. These tumors are more common in females aged over 40 years. The palate was the most common affected site.

Abstract: Background: The studies found in the literature associate the immunoexpression of hMLH1 and hMSH2 proteins with histologic aspects, but do not correlate it with clinical and epidemiological data. Objective: To evaluate the immunoexpression of hMLH1 and hMSH2 in actinic cheilitis, correlating it with clinical characteristics. Methods: We analyzed 40 cases. Histological and immunohistochemical analyses were performed. The following clinical variables were evaluated: gender, age range, ethnicity, clinical aspect and occupational sunlight exposure. Statistical evaluation included the Student t-test, while the significance level was set at 5%. Results: Greater immunoexpression of hMLH1 and hMSH2 was observed in females, individuals aged over 40, and mixed-race/black patients. Furthermore, the immunoexpression of these proteins was greater in actinic cheilitis with a white-colored appearance and in patients without occupational sunlight exposure. No statistical differences were observed for the variables studied. Conclusion: This study uncovered variations of hMLH1 and hMSH2 protein expression upon evaluation of clinical aspects in actinic cheilitis.

Avaliar a relação entre o tabagismo e os fatores comportamentais e sociodemográficos entre acadêmicos da área de saúde da Universidade Estadual da Paraíba (UEPB). Foi realizado um estudo transversal analítico, no qual foi obtida uma amostra representativa de cada curso (Odontologia, Enfermagem, Psicologia, Farmácia, Fisioterapia e Educação Física). Foram entrevistados 492 alunos por meio de formulário estruturado. Os testes estatísticos utilizados foram Qui-quadrado e o Exato de Fisher (significância de 5%). A prevalência de tabagismo foi de 5,7% e o estresse foi a principal razão para o início do hábito (36,8%). Na análise multivariada por regressão logística as variáveis, sexo, prática de religião, período cursado e consumo etílico apresentaram-se associadas ao hábito de fumar (p<0,05). Apesar de estudos relatarem uma forte relação entre estudantes universitários e fumo, a prevalência de tabagismo foi baixa. A maioria das variáveis estudadas demonstrou associação com o hábito de fumar. Sendo o fumo e o álcool as duas maiores dependências humanas, este estudo sugere uma relação bidirecional entre estas variáveis.

The aim of this study was to evaluate the relationship between smoking and socio-demographic and behavioral factors among undergraduate students in the area of health at the State University of Paraíba, Brazil. An analytical cross-sectional study was conducted with a representative sample from each of the following courses: Dentistry, Nursing, Psychology, Pharmacy, Physical Therapy and Physical Education. A total of 492 students were interviewed using a structured questionnaire. The chi-square and Fisher's Exact tests were used for statistical analysis at a 5% level of significance. Smoking prevalence was 5.7% and stress was the main reason for starting the habit (36.8%). In the multivariate analysis by logistic regression, the variables of gender, religious persuasion, semester attended in the course, and alcohol consumption were significantly associated with smoking (p<0.05). Although other studies reported a strong relationship between university students and smoking, the prevalence of smokers was low. Most of the variables studied revealed a correlation with smoking. Since smoking and alcohol consumption are the two major human addictions, this study suggests a bidirectional relationship between these variables.

Avaliar a relação entre o tabagismo e os fatores comportamentais e sociodemográficos entre acadêmicos da área de saúde da Universidade Estadual da Paraíba (UEPB). Foi realizado um estudo transversal analítico, no qual foi obtida uma amostra representativa de cada curso (Odontologia, Enfermagem, Psicologia, Farmácia, Fisioterapia e Educação Física). Foram entrevistados 492 alunos por meio de formulário estruturado. Os testes estatísticos utilizados foram Qui-quadrado e o Exato de Fisher (significância de 5%). A prevalência de tabagismo foi de 5,7% e o estresse foi a principal razão para o início do hábito (36,8%). Na análise multivariada por regressão logística as variáveis, sexo, prática de religião, período cursado e consumo etílico apresentaram-se associadas ao hábito de fumar (p<0,05). Apesar de estudos relatarem uma forte relação entre estudantes universitários e fumo, a prevalência de tabagismo foi baixa. A maioria das variáveis estudadas demonstrou associação com o hábito de fumar. Sendo o fumo e o álcool as duas maiores dependências humanas, este estudo sugere uma relação bidirecional entre estas variáveis.

The aim of this study was to evaluate the relationship between smoking and socio-demographic and behavioral factors among undergraduate students in the area of health at the State University of Paraíba, Brazil. An analytical cross-sectional study was conducted with a representative sample from each of the following courses: Dentistry, Nursing, Psychology, Pharmacy, Physical Therapy and Physical Education. A total of 492 students were interviewed using a structured questionnaire. The chi-square and Fisher's Exact tests were used for statistical analysis at a 5% level of significance. Smoking prevalence was 5.7% and stress was the main reason for starting the habit (36.8%). In the multivariate analysis by logistic regression, the variables of gender, religious persuasion, semester attended in the course, and alcohol consumption were significantly associated with smoking (p<0.05). Although other studies reported a strong relationship between university students and smoking, the prevalence of smokers was low. Most of the variables studied revealed a correlation with smoking. Since smoking and alcohol consumption are the two major human addictions, this study suggests a bidirectional relationship between these variables.