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RESUMO CONTEXTO: As doenças inflamatórias intestinais (DII) são afecções inflamatórias crônicas de caráter recorrente, cujas taxas de incidência e prevalência têm aumentado, inclusive no Brasil. A longo prazo, são responsáveis por danos estruturais que impactam na qualidade de vida, morbidade e mortalidade dos pacientes. OBJETIVO: Avaliar o perfil dos médicos que atendem pacientes com DII, assim como as características deste atendimento, demandas não atendidas e dificuldades. MÉTODOS: Um questionário contendo 17 variáveis foi elaborado e enviado para médicos, selecionados a partir do cadastro da Comissão das Estaduais do Grupo de Estudos da Doença Inflamatória Intestinal do Brasil (GEDIIB), totalizando 286 médicos de 101 cidades brasileiras distribuídas por 21 estados e Distrito Federal. RESULTADOS: A maioria dos médicos que respondeu o questionário foram Gastroenterologistas e Coloproctologistas. Mais de 60% tinham até 20 anos de atuação na especialidade e 53,14% trabalhavam em três locais ou mais. A dificuldade no acesso ou liberação de medicamentos ficou evidenciada neste questionário, assim como a dificuldade no encaminhamento para profissionais não médicos que atuam em DII. Mais de 75% dos médicos relataram dificuldades para realização de enteroscopia por duplo balão e cápsula endoscópica, e 67,8% para realização da calprotectina. Em relação ao número de pacientes atendidos por cada médico, foi evidenciado que não há uma concentração de pacientes sob a responsabilidade de poucos médicos. O infliximabe e o adalimumabe foram os biológicos mais utilizados e ficou evidenciada prescrição maior de derivados de 5-ASA para retocolite ulcerativa quando comparada à doença de Crohn. Os corticoides foram prescritos para uma parcela menor de pacientes em ambas doenças. Os temas “falha a terapia biológica” e “novas drogas” foram referidos como aqueles com maior prioridade para discussão em eventos científicos. Em relação às possíveis diferenças entre cada região e o restante do país, os médicos da região Norte relataram maior dificuldade no acesso a exames complementares e os médicos da região Nordeste, maior dificuldade no acesso ou liberação de medicamentos. CONCLUSÃO: Os dados obtidos por meio deste estudo mostram o perfil do atendimento médico especializado em DII e podem se constituir em ferramenta útil para para elaboração de políticas governamentais e para sociedade brasileira como um todo.

ABSTRACT BACKGROUND: Inflammatory bowel diseases (IBD) are chronic inflammatory affections of recurrent nature whose incidence and prevalence rates have increased, including in Brazil. In long term, they are responsible for structural damage that impacts quality of life, morbidity and mortality of patients. OBJECTIVE: To describe the profile of physicians who treat IBD patients as well as the characteristics of IBD care, unmet demands and difficulties. METHODS: A questionnaire containing 17 items was prepared and sent to 286 physicians from 101 Brazilian cities across 21 states and the Federal District, selected from the register of the State Commission of the “Study Group of Inflammatory Bowel Disease of Brazil” (GEDIIB). RESULTS: The majority of the physicians who answered the questionnaire were gastroenterologists and colorectal surgeons. More than 60% had up to 20 years of experience in the specialty and 53.14% worked at three or more locations. Difficulties in accessing or releasing medicines were evident in this questionnaire, as was referrals to allied healthy professionals working in IBD-related fields. More than 75% of physicians reported difficulties in performing double-balloon enteroscopy and capsule endoscopy, and 67.8% reported difficulties in measuring calprotectin. With regard to the number of patients seen by each physician, it was shown that patients do not concentrate under the responsibility of few doctors. Infliximab and adalimumab were the most commonly used biological medicines and there was a higher prescription of 5-ASA derivatives for ulcerative colitis than for Crohn’s disease. Steroids were prescribed to a smaller proportion of patients in both diseases. The topics “biological therapy failure” and “new drugs” were reported as those with higher priority for discussion in medical congresses. In relation to possible differences among the country’s regions, physicians from the North region reported greater difficulty in accessing complementary exams while those from the Northeast region indicated greater difficulty in accessing or releasing medicines. CONCLUSION: The data obtained through this study demonstrate the profile of specialized medical care in IBD and are a useful tool for the implementation of government policies and for the Brazilian society as a whole.

https://doi.org/10.1590/s0004-2803.202000000-77 1133 downloads

Elaboration, evaluation of nutritional information and physical-chemical stability of dairy fermented drink with caja-mango pulp
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Souza, Handray Fernandes de

; Borges, Lara Aguiar

; Lopes, João Pedro Antunes

; Carvalho, Bruna Mara Aparecida de

; Santos, Sérgio Henrique Sousa

; Almeida, Anna Christina de

; Lima, William James Nogueira

; Brandi, Igor Viana

Ciência Rural

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2020, Volume 50 N. 1 elocation e20190644

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: O soro lácteo é um subproduto da indústria de laticínios de grande importância devido ao seu alto valor nutritivo, podendo ser utilizado para fabricação de bebida láctea fermentada que, associada a frutas, aumenta o valor nutricional e agrega sabores característicos. A partir disso, foi elaborada uma bebida láctea fermentada adicionada de polpa de cajá-manga (Spondias dulcis), sendo avaliada sua informação nutricional bem como a estabilidade físico-química, durante o armazenamento. Os resultados mostram que a informação nutricional atendeu os requisitos estipulados pela legislação brasileira. A estabilidade físico-química da bebida, quanto aos parâmetros analisados de pH, acidez, sinerese e sedimentação, sofreu influência pelo o tempo de armazenamento, possivelmente, associados a fatores não controlados neste estudo como a concentração de cultura láctea iniciadora e final do produto elaborado, a biodegradação de proteínas durante a estocagem e baixos teores de sólidos. Conclui-se que a bebida elaborada constitui um alimento fonte de diversos nutrientes, e poderá complementar a alimentação diária de crianças, adolescentes e adultos, suprindo as carências nutricionais.

ABSTRACT: Whey is a by-product of the dairy industry of great importance due to its high nutritional value, and can be used for the manufacture of fermented dairy drinks which, combined with fruit, increase the nutritional value and add characteristic flavors. Therefore, a fermented dairy beverage with caja-mango pulp (Spondias dulcis) was elaborated and its nutritional information as well as the physical-chemical stability were evaluated during storage. The results showed that the nutritional information met the requirements stipulated by the Brazilian legislation. The physical-chemical stability of the dairy fermented drink in terms of pH, acidity, syneresis and sedimentation was influenced by the storage time, possibly associated with uncontrolled factors in this study, such as the initial and final dairy culture concentration of the processed product, protein biodegradation during storage and low solids contents. It is concluded that the elaborated drink constitutes a food source of several nutrients, and may complement the daily diet of children, adolescents and adults, supplying nutritional deficiencies.

https://doi.org/10.1590/0103-8478cr20190644 1329 downloads

Polymorphisms of the renin-angiotensin system are not associated with overweight and obesity in a general adult population
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Lelis, Deborah de Farias

; Pereira, Alexandre Costa

; Krieger, José Eduardo

; Mill, José Geraldo

; Santos, Sérgio Henrique Sousa

; Baldo, Marcelo Perim

Archives of Endocrinology and Metabolism

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aug 2019, Volume 63 N. 4 Pages 402 - 410

Abstract: En | Text: En | PDF: En

ABSTRACT Objective The increased prevalence of obesity and associated comorbidities, such as cardiovascular and metabolic diseases, has gained attention worldwide, and the renin-angiotensin system (RAS) has been pointed out as a possible link. Thus, the present study aimed to verify the possible association between angiotensinogen (AGT) or angiotensin-converting enzyme (ACE) polymorphisms with overweight and obesity in adults. Subjects and methods The present investigation was a population-based cross-sectional study including 1,567 individuals from an urban area in Brazil. Anthropometric, clinical and biochemical parameters were evaluated, and all individuals were genotyped for the ACE I/D and AGT M/T polymorphisms. Results The prevalence of overweight was higher among men, whereas obesity was more prevalent among women. However, the frequency of ACE or AGT polymorphisms was similar among body mass index (BMI) categories. In addition, the mean age-adjusted BMI averages did not change significantly for ACE or AGT polymorphisms, regardless of sex or BMI category. The age-adjusted BMI average for the combination of ACE and AGT genotypes evidenced no significant differences regardless of sex or BMI categories. Results were similar when BMI was replaced by waist circumference (WC). Conclusions We were not able to find any associations between BMI and WC (overweight/obesity) and ACE and AGT polymorphisms, indicating that the RAS system might not be involved in overweight and obesity, at least based on genetic backgrounds. However, further studies must measure RAS components to elucidate this question.

https://doi.org/10.20945/2359-3997000000155 669 downloads

Hierarchical Analysis of Hypertension with the Polymorphic Variant of the ACE Gene and Other Risk Factors in the Elderly
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Ribeiro, Breno Barreto

; Santos Neto, Pedro Eleutério dos

; Nascimento, Jairo Evangelista

; Andrade, João Marcus Oliveira

; Paraíso, Alanna Fernandes

; Santos, Sérgio Henrique Sousa

; Silveira, Marise Fagundes

; Martins, Andréa Maria Eleutério de Barros Lima

International Journal of Cardiovascular Sciences

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feb 2017, Volume 30 N. 1 Pages 52 - 60

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamento: A hipertensão arterial sistêmica (HAS) é uma condição clínica de etiologia multifatorial e de sério agravo à saúde do idoso. Apesar das alterações cardiovasculares influenciarem o desenvolvimento da HAS nesta faixa etária, vários outros fatores genéticos e ambientais têm sido descritos na literatura, incluindo a variante polimórfica do gene da enzima conversora da angiotensina (ECA) e a distribuição da gordura corporal. Objetivo: Avaliar a prevalência da HAS entre idosos e sua possível correlação com a variante polimórfica I/D do gene da ECA e outros fatores de risco associados. Métodos: Estudo de base populacional com 387 idosos residentes na zona urbana de Ibiaí (MG, Brasil) utilizando, para tal, um modelo hierarquizado. Resultados: À análise estatística, a variante polimórfica do gene da ECA não se mostrou associada à HAS (p = 0,316). Por outro lado, mostraram associação significativa com a HAS os fatores: sexo feminino, ausência de companheiro, consumo de mais de uma porção de sal ao dia e alterações nos índices de massa corporal e na relação cintura-quadril. Conclusão: Apesar da variante polimórfica da ECA não ter mostrado influência sobre a prevalência de HAS em idosos, algumas variáveis individuais, socioeconômicas, metabólicas e de hábitos comportamentais mostraram associação com esta condição.

Abstract Background: Hypertension is a clinical condition of multifactorial etiology that imposes serious harm to the health of elderly individuals. Despite the fact that cardiovascular disorders influence the development of hypertension in this age group, several other genetic and environmental factors have been described in the literature, including the polymorphic variant of the angiotensin-converting enzyme (ACE) gene and the distribution of body fat. Objective: To assess the prevalence of hypertension among elderly individuals and its possible correlation with the I/D polymorphic variant of the ACE gene and other associated risk factors. Methods: Population-based study using a hierarchical model and including 387 elderly individuals residing in the urban area of Ibiaí (Minas Gerais, Brazil). Results: On statistical analysis, the polymorphic variant of the ACE gene was not associated with hypertension (p = 0.316). On the other hand, there was a significant association between hypertension and the variables female sex, absence of a partner, consumption of more than one portion of salt per day, and changes in body mass index and waist-to-hip ratio. Conclusion: Although the polymorphic variant of the ACE gene showed no influence on the prevalence of hypertension in elderly individuals, some variables such as individual, socioeconomic, metabolic, and behavioral habits were associated with this condition.

https://doi.org/10.5935/2359-4802.20170031 2792 downloads

Consumption of baru nuts (Dipteryx alata) in the treatment of obese mice
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Araújo, Andreia Cristina Ferraz

; Rocha, Juliete Castro

; Paraiso, Alanna Fernandes

; Ferreira, Adaliene Versiani Matos

; Santos, Sergio Henrique Sousa

; Pinho, Lucineia de

Ciência Rural

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2017, Volume 47 N. 2 elocation 20151337

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Este estudo analisou os efeitos do consumo de amêndoas de baru no peso corporal, percentagem de adiposidade, quantidade de tecido adiposo e parâmetros sanguíneos em camundongos Swiss machos e obesos. Após indução da obesidade pelo consumo de dieta hiperglicídica (60 dias), os camundongos foram divididos em 4 grupos (7 animais por grupo) e, consumiram dieta controle (C), hipergicídica (HG) ou hiperglicídica com adição de baru (HGBA) ou óleo de soja (HGOS). O grupo que ingeriu HGBA teve redução no ganho de peso e níveis de glicose e triglicérides comparados ao tratamento com dieta HG. Os animais alimentados com HG exibiram uma maior proporção de tecido adiposo epididimal e retroperitoneal. Conclui-se que a inclusão de amêndoa de baru na dieta melhora o controle do ganho de peso e os níveis de glicose e triglicérides em camundongos obesos.

ABSTRACT: The present study evaluated the effects of baru nut consumption on body weight, percent adiposity, amount of adipose tissue and blood levels in obese male Swiss mice. After inducing obesity by providing high-glucose diet (60 days), the mice were divided into 4 groups (7 animals per group) and were fed on a control diet (C), high-glucose diet (HG) or high-glucose diet added with baru (HGBA) or soybean oil (HGSO). Groups fed with diet HGBA had a decrease in the weight gain and glucose and triglyceride levels when compared to diet HG. Aimals fed with HG exhibited a higher proportion of epididymal and retroperitoneal adipose tissue. The inclusion of baru nut in the diet improved the control of weight gain and glucose and triglyceride levels in obese mice.

https://doi.org/10.1590/0103-8478cr20151337 2953 downloads

Excesso de peso e consumo alimentar em adolescentes de escolas públicas no norte de Minas Gerais, Brasil
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Pinho, Lucinéia de

; Flávio, Eliete Fernandes

; Santos, Sérgio Henrique Sousa

; Botelho, Ana Cristina de Carvalho

; Caldeira, Antônio Prates

Ciência & Saúde Coletiva

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jan 2014, Volume 19 N. 1 Pages 67 - 74

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Este estudo objetivou identificar a prevalência excesso de peso e o consumo alimentar entre adolescentes de rede pública de ensino ao norte de Minas Gerais. Desenvolveu-se estudo transversal com amostra aleatória e representativa de adolescentes. Foram coletadas informações demográficas e econômicas. O consumo alimentar foi avaliado pela aplicação de questionário semiquantitativo. Aferiu-se peso e altura para avaliação do estado nutricional com base no Índice de Massa Corporal (IMC) por Idade. A comparação entre os gêneros foi conduzida por meio do teste t de Student (médias) ou qui-quadrado (proporções), assumindo-se um nível de significância de p < 0,05. Foram avaliados 535 adolescentes e registrada uma prevalência de excesso de peso para 18,5%. Houve diferença significativa entre os gêneros para o IMC (p = 0,001), maior entre as meninas. O consumo médio de energia foi de 3.096,30kcal/dia. Observou-se consumo insuficiente de fibras em 35% dos adolescentes, de cálcio e vitamina A em 80% e gorduras insaturadas em 100%. Carboidratos e colesterol eram consumidos em excesso por 20,6% e 48%, respectivamente. A prevalência do excesso de peso e o consumo alimentar inadequado mostrou-se preocupante para a população estudada e demandam adequada intervenção nutricional.

This study sought to identify the prevalence of excess weight and food consumption patterns among adolescents attending public schools in northern Minas Gerais state. A cross-sectional study was conducted with a random and representative sample of adolescents. Demographic and economic data were collected. Food consumption was evaluated by applying a semi-quantitative food questionnaire. Body weight and height were measured to assess the nutritional status based on the Body Mass Index (BMI) by Age. The sexes were compared by Student's t test (comparison of samples) and chi-square test (goodness of fit) at a level of significance of p <0.05. 535 adolescents were evaluated and prevalence of excess weight was detected in 18.5% of the group. BMI (p = 0,001) was statistically different between the sexes and higher for girls. The average energy consumption of the group was 3096.30 kcal/day. Fiber consumption was insufficient in 35% of the adolescents, vitamin A and calcium in 80% and unsaturated fats in 100%. Carbohydrate and cholesterol were consumed in excess by 20.6% and 48%, respectively. The prevalence of excess weight and inadequate food consumption is of great concern for the population studied and requires appropriate nutritional intervention.

https://doi.org/10.1590/1413-81232014191.1968 4885 downloads

Excesso de peso e consumo alimentar em adolescentes de escolas públicas no norte de Minas Gerais, Brasil
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Pinho, Lucinéia de

; Flávio, Eliete Fernandes

; Santos, Sérgio Henrique Sousa

; Botelho, Ana Cristina de Carvalho

; Caldeira, Antônio Prates

Ciência & Saúde Coletiva

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jan 2014, Volume 19 N. 1 Pages 67 - 74

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232014191.1968 3192 downloads

Low expression of MSH2 DNA repair protein is associated with poor prognosis in head and neck squamous cell carcinoma
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Pereira, Camila Santos

; Oliveira, Marcos Vinicius Macedo de

; Barros, Lucas Oliveira

; Bandeira, Gabriela Alencar

; Santos, Sergio Henrique Sousa

; Basile, John R.

; Guimaraes, Andre Luiz Sena

; De Paula, Alfredo Mauricio Batista

Journal of Applied Oral Science

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sep 2013, Volume 21 N. 5 Pages 416 - 421

Abstract: En | Text: En | PDF: En

OBJECTIVE: This study aimed to investigate the expression of the MSH2 DNA repair protein in head and neck squamous cell carcinoma (HNSCC) in order to analyze its association with clinicopathologic factors and overall survival of patients. MATERIAL AND METHODS: Clinical data and primary lesions of HNSSC were collected from 55 patients who underwent surgical resection with postoperative radiotherapy in Montes Claros, state of Minas Gerais, Brazil, between 2000 and 2008. Immunohistochemical reactions were performed to analyze MSH2 protein expression. RESULTS: Bivariate analysis showed no significant correlation or association between MSH2 expression and clinicopathologic parameters by Mann-Whitney and Kruskal-Wallis tests. Patients with locoregional metastatic disease (OR=4.949, p<0.001) and lower MSH2 immunohistochemical expressions (OR=2.943, p=0.032) presented poorer survival for HNSCC by Cox regression models. CONCLUSIONS: Our data demonstrated that lower MSH2 expression might contribute to a higher clinic aggressiveness of HNSCC by promoting an unfavorable outcome.

https://doi.org/10.1590/1679-775720130206 2100 downloads Cited 1 time in SciELO

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