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Abstract This paper presents an eyebolt structural fault detection system, based on the analysis of multiple electromagnetic parameters through a random forest classifier trained by both measurements and high-fidelity simulated signals. The proposed methodology is completely noninvasive and does not require the disassembly of the electrical infrastructure, allowing the live-line working. The obtained results show that the proposed multi-parameter strategy achieves high accuracy and increases the system’s capability of detecting faults, improving the efficiency of the operator’s preventive maintenance routines and, consequently, increasing the reliability of the power supply and energy distribution systems. system highfidelity fidelity signals infrastructure liveline live line working multiparameter multi parameter systems s faults operators operator consequently

https://doi.org/10.1590/2179-10742023v22i3271067

Cognitive impairments associated with chemotherapy in women with breast cancer: a meta-analysis and meta-regression cancer metaanalysis meta analysis metaregression regression
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Oliveira, M.E.C.

; Torres, G.S.V.

; Franklin, R.G.

; Gomes, K.A.L.

; Nóbrega, W.F.S.

; Fernandes, T.P.

; Santos, N.A.

Brazilian Journal of Medical and Biological Research

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2023, Volume 56 elocation e12947

Abstract: En | Text: En | PDF: En

Chemotherapy is one of the most widely used treatments for breast cancer (BC). However, there is evidence of side effects like cognitive changes related to the chemotherapy treatment. The aim of the study was not only to summarize the existing evidence on the relationship between chemotherapy and cognitive performance in women with BC but also to identify additional consequences and aspects associated with these impairments. We conducted a systematic review with meta-analysis and meta-regression to present updated information on the matter. We retrieved data from the databases PubMed, Web of Science, PsycINFO, CINAHL, and Scopus. Twenty studies comprising over 2,500 women were examined and the results indicated that chemotherapy can compromise cognition in women with BC (-1.10 OR [95%CI: -1.81 to -0.74], P<0.01), with working memory (-0.49 OR [95%CI: -0.85 to -0.13], P=0.03) being the most affected among the domains. Furthermore, additional data indicated that cognitive impairment is most likely amid women with BC having a lower education level (Q=4.85, P=0.02). Our results suggested that chemotherapy affects cognitive functions in women with BC, and certain characteristics can worsen the deterioration. A comprehensive study of women with breast cancer and existing predictors contributes to optimized personal journeys, elevated life prospects, and advanced care that can also aid prognosis and therapeutic approaches. BC. . (BC) However treatment impairments metaanalysis meta analysis metaregression regression matter PubMed Science PsycINFO CINAHL Scopus 2500 2 500 2,50 1.10 110 1 10 (-1.1 95%CI 95CI CI 95 [95%CI 1.81 181 81 -1.8 0.74, 074 0.74 , 0 74 -0.74] P<0.01, P001 P P<0.01 01 P<0.01) 0.49 049 49 (-0.4 0.85 085 85 -0.8 0.13, 013 0.13 13 -0.13] P=0.03 P003 03 domains Furthermore Q=4.85, Q485 Q 4 (Q=4.85 P=0.02. P002 P=0.02 02 P=0.02) deterioration journeys prospects approaches (BC 250 50 2,5 1.1 11 (-1. 9 1.8 18 8 -1. 07 0.7 7 -0.74 P00 P<0.0 0.4 04 (-0. 0.8 08 -0. 0.1 -0.13 P=0.0 Q=4.85 Q48 (Q=4.8 25 5 2, 1. (-1 -1 0. -0.7 P0 P<0. (-0 -0 -0.1 P=0. Q=4.8 Q4 (Q=4. (- - P<0 P=0 Q=4. (Q=4 ( P< P= Q=4 (Q= Q= (Q

https://doi.org/10.1590/1414-431x2023e12947

GEOTECHNOLOGIES APPLIED TO THE BEHAVIORAL STUDY OF URBAN HEAT ISLANDS
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Costa, G.A.

; Santos, A.R.

; Pirovani, D.B.

; Dias, H.M.

; Carvalho, R.C.F.

; Carvalho, J.R.

; Souza, K.B.

; Moreira, T.R.

; Silva, R.G.

; Senhorelo, A.P.

; Kunz, S.H.

Mercator (Fortaleza)

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2023, Volume 22 elocation e22022

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Muitas cidades são impactadas pelo efeito das ilhas de calor. Neste contexto, objetivou-se com esse analisar a distribuição espacial e temporal das ilhas de calor urbanas e a influência das áreas verdes na formação dos microclimas urbanos no município do Rio de Janeiro. Como resultados, observou-se que Rio de Janeiro encontra-se sob influência das ilhas de calor, as áreas mais antigas da cidade e sobretudo mais urbanizadas são as mais acometidas pelas altas temperaturas. Foi possível constatar o papel da vegetação na formação dos microclimas urbanos por meio do coordenador de psicologia negativa entre a temperatura da superfície (Ts) e os índices de vegetação (NDVI) e (EVI), e ainda um coeficiente de transferência positiva entre Temperatura da Superfície (Ts) e Índice de Áreas Construídas por Diferença Normalizada (NDBI), demonstrando a influência da urbanização no aumento da temperatura. contexto objetivouse objetivou se resultados observouse observou encontrase encontra temperaturas Ts (Ts NDVI (NDVI EVI, EVI , (EVI) NDBI, NDBI (NDBI) (EVI (NDBI

Abstract Many cities are impacted by the effect of heat islands. In this context, the aim of this study was to analyze the spatial and temporal distribution of urban heat islands and the influence of green areas on the formation of urban microclimates in the city of Rio de Janeiro. As a result, it was observed that Rio de Janeiro city is under heat islands influence, in which the oldest and most urbanized areas of the city are the most affected by high temperatures. It was possible to verify the role of vegetation in the formation of urban microclimates through the negative correlation coefficient between surface temperature (Ts) and vegetation indexes (NDVI and EVI), along with the positive correlation coefficient between surface temperature (Ts) and the Index of Areas Built by Normalized Difference (NDBI), what demonstrates the influence of urbanization on the increase of temperature. context result temperatures Ts (Ts NDVI EVI, EVI , EVI) NDBI, NDBI (NDBI) (NDBI

Resumen Muchas ciudades se ven afectadas por el efecto de las islas de calor. En este contexto, el objetivo de este estudio fue analizar la distribución espacial y temporal de las islas de calor urbanas y la influencia de las áreas verdes en la formación de los microclimas urbanos en el municipio de Río de Janeiro, Brasil. Como resultados, se observó que Río de Janeiro está influenciada por las islas de calor, siendo las áreas más antiguas y urbanizadas las más afectadas por altas temperaturas. Se pudo constatar el papel de la vegetación en la formación de los microclimas urbanos mediante el coeficiente de correlación negativo entre la temperatura de la superficie (Ts) y los índices de vegetación (NDVI) y (EVI), así como un coeficiente de correlación positivo entre la temperatura de la superficie (Ts) y el Índice de Áreas Construidas por Diferencia Normalizada (NDBI), lo que demuestra la influencia de la urbanización en el aumento de la temperatura. contexto Brasil resultados temperaturas Ts (Ts NDVI (NDVI EVI, EVI , (EVI) NDBI, NDBI (NDBI) (EVI (NDBI

https://doi.org/10.4215/rm2023.e22022

Matteucinol combined with temozolomide inhibits glioblastoma proliferation, invasion, and progression: an in vitro, in silico, and in vivo study
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Netto, J.B.

; Melo, E.S.A.

; Oliveira, A.G.S.

; Sousa, L.R.

; Santiago, L.R.

; Santos, D.M.

; Chagas, R.C.R.

; Gonçalves, A.S.

; Thomé, R.G.

; Santos, H.B.

; Reis, R.M.

; Ribeiro, R.I.M.A.

Brazilian Journal of Medical and Biological Research

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2022, Volume 55 elocation e12076

Abstract: En | Text: En | PDF: En

Glioblastoma is the most prevalent and malignant brain tumor identified in adults. Surgical resection followed by radiotherapy and chemotherapy, mainly with temozolomide (TMZ), is the chosen treatment for this type of tumor. However, the average survival of patients is around 15 months. Novel approaches to glioblastoma treatment are greatly needed. Here, we aimed to investigate the anti-glioblastoma effect of the combination of matteucinol (Mat) (dihydroxyflavanone derived from Miconia chamissois Naudin) with the chemotherapeutic TMZ in vitro using tumor (U-251MG) and normal astrocyte (NHA) cell lines and in vivo using the chick embryo chorioallantoic membrane (CAM) assay. The combination was cytotoxic and selective for tumor cells (28 μg/mL Mat and 9.71 μg/mL TMZ). Additionally, the combination did not alter cell adhesion but caused morphological changes characteristic of apoptosis in vitro. Notably, the combination was also able to reduce tumor growth in the chick embryo model (CAM assay). The docking results showed that Mat was the best ligand to the cell death membrane receptor TNFR1 and to TNFR1/TMZ complex, suggesting that these two molecules may be working together increasing their potential. In conclusion, Mat-TMZ can be a good candidate for pharmacokinetic studies in view of clinical use for the treatment of glioblastoma.

https://doi.org/10.1590/1414-431x2022e12076

Riboflavin did not provide anti-inflammatory or antioxidant effects in an experimental model of sepsis
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Vale, A.H.F.

; Nascimento, D.C.

; Pineros, A.R.

; Ferreira, R.G.

; Santos, J.D.

; Aragon, D.C.

; Cunha, F.Q.

; Ramalho, F.S.

; Alves-Filho, J.C.

; Carlotti, A.P.C.P.

Brazilian Journal of Medical and Biological Research

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2022, Volume 55 elocation e12107

Abstract: En | Text: En | PDF: En

We aimed to evaluate whether the administration of riboflavin to septic animals reduces inflammation, oxidative stress, organ dysfunction, and mortality. C57BL/6 mice, 6-8 weeks old, were allocated to the study group (polymicrobial sepsis induced by cecal ligation and puncture (CLP) + antibiotic + iv riboflavin), control (CLP + antibiotic + iv saline), or naïve (non-operated controls). Serum concentrations of alanine aminotransferase (ALT), creatine kinase-MB (CK-MB), urea, and creatinine, and markers of inflammation [interleukin (IL)-6, tumor necrosis factor (TNF)-α, keratinocyte-derived chemokine (KC), and macrophage inflammatory protein (MIP)-2)], and oxidative stress (malondialdehyde (MDA) were measured 12 h after the experiment. Animal survival rates were calculated after 7 days. Means between groups were compared using linear regression models adjusted under the Bayesian approach. No significant difference was observed between control and study groups in serum concentrations of IL-6 (95% credible interval) (-0.35 to 0.44), TNF-α (-15.7 to 99.1), KC (-0.13 to 0.05), MIP-2 (-0.84 to 0.06), MDA (-1.25 to 2.53), or ALT (-6.6 to 11.5). Serum concentrations of CK-MB (-145.1 to -30.1), urea (-114.7 to -15.1), and creatinine (-1.14 to -0.01) were higher in the study group. Survival was similar in both groups (P=0.8). Therefore, the use of riboflavin in mice undergoing sepsis induced by CLP did not reduce inflammation, oxidative stress, organ dysfunction, or mortality compared with placebo.

https://doi.org/10.1590/1414-431x2022e12107

Impact of chronic obstructive pulmonary disease on linear and nonlinear dynamics of heart rate variability in patients with heart failure
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Goulart, C.L.

; Caruso, F.R.

; Arêas, G.P.T.

; Santos, P.B. dos

; Camargo, P.F.

; Carvalho, L.C.S. de

; Roscani, M.G.

; Mendes, R.G.

; Borghi-Silva, A.

Brazilian Journal of Medical and Biological Research

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2021, Volume 54 N. 2 elocation e10084

Abstract: En | Text: En | PDF: En

The objective of this study was to investigate the impact of chronic obstructive pulmonary disease (COPD)-heart failure (HF) coexistence on linear and nonlinear dynamics of heart rate variability (HRV). Forty-one patients (14 with COPD-HF and 27 HF) were enrolled and underwent pulmonary function and echocardiography evaluation to confirm the clinical diagnosis. Heart rate (HR) and R-R intervals (iRR) were collected during active postural maneuver (APM) [supine (10 min) to orthostasis (10 min)], respiratory sinus arrhythmia maneuver (RSA-M) (4 min), and analysis of frequency domain, time domain, and nonlinear HRV. We found expected autonomic response during orthostatic changes with reduction of mean iRR, root mean square of successive differences between heart beats (RMSSD), RR tri index, and high-frequency [HF (nu)] and an increased mean HR, low-frequency [LF (nu)], and LF/HF (nu) compared with supine only in HF patients (P<0.05). Patients with COPD-HF coexistence did not respond to postural change. In addition, in the orthostatic position, higher HF nu and lower LF nu and LF/HF (nu) were observed in COPD-HF compared with HF patients. HF patients showed an opposite response during RSA-M, with increased sympathetic modulation (LF nu) and reduced parasympathetic modulation (HF nu) (P<0.05) compared with COPD-HF patients. COPD-HF directly influenced cardiac autonomic modulation during active postural change and controlled breathing, demonstrating an autonomic imbalance during sympathetic and parasympathetic maneuvers compared with isolated HF.

https://doi.org/10.1590/1414-431x202010084 840 downloads

Reliability and validity of six-minute step test in patients with heart failure
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Marinho, R.S.

; Jürgensen, S.P.

; Arcuri, J.F.

; Goulart, C.L.

; Santos, P.B. dos

; Roscani, M.G.

; Mendes, R.G.

; Oliveira, C.R. de

; Caruso, F.R.

; Borghi-Silva, A.

Brazilian Journal of Medical and Biological Research

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2021, Volume 54 N. 10 elocation e10514

Abstract: En | Text: En | PDF: En

Exercise intolerance is the hallmark consequence of advanced chronic heart failure (HF). The six-minute step test (6MST) has been considered an option for the six-minute walk test because it is safe, inexpensive, and can be applied in small places. However, its reliability and concurrent validity has still not been investigated in participants with HF with reduced ejection fraction (HFrEF). Clinically stable HFrEF participants were included. Reliability and error measurement were calculated by comparing the first with the second 6MST result. Forty-eight hours after participants underwent the 6MST, they were invited to perform a cardiopulmonary exercise test (CPET) on a cycle ergometer. Concurrent validity was assessed by correlation between number of steps and peak oxygen uptake (V̇O2 peak) at CPET. Twenty-seven participants with HFrEF (60±8 years old and left ventricle ejection fraction of 41±6%) undertook a mean of 94±30 steps in the 6MST. Intra-rater reliability was excellent for 6MST (ICC=0.9), with mean error of 4.85 steps and superior and inferior limits of agreement of 30.6 and -20.9 steps, respectively. In addition, strong correlations between number of steps and CPET workload (r=0.76, P<0.01) and peak V̇O2 (r=0.71, P<0.01) were observed. From simple linear regression the following predictive equations were obtained with 6MST results: V̇O2 peak (mL/min) = 350.22 + (7.333 × number of steps), with R2=0.51, and peak workload (W) = 4.044 + (0.772 × number of steps), with R2=0.58. The 6MST was a reliable and valid tool to assess functional capacity in HFrEF participants and may moderately predict peak workload and oxygen uptake of a CPET.

https://doi.org/10.1590/1414-431x2020e10514 220 downloads

Does the Use of Adjuvants Alter Surface Tension and Contact Angle of Herbicide Spray Droplets on Leaves of Sida spp.?
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SANTOS, R.T.S.

; FERREIRA, M.C.

; VIANA, R.G.

Planta Daninha

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2019, Volume 37 elocation e019185603

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: O espalhamento das gotas sobre superfícies vegetais pode indicar melhor eficiência numa aplicação de herbicidas. Com este trabalho, objetivou-se avaliar a tensão superficial e o ângulo de contato de gotas do herbicida aminopiralide + fluroxipir associado a adjuvantes sobre a superfície foliar de três espécies do gênero Sida. O experimento foi realizado em delineamento inteiramente ao acaso, disposto em arranjo fatorial 4x2+1, com quatro repetições. Foram utilizadas oito caldas contendo duas dosagens do herbicida (0,04 + 0,08 kg i.a. ha-1 e 0,08+0,16 kg i.a. ha -1), associado ou não aos adjuvantes óleo vegetal, óleo mineral e lecitina, e água como testemunha. Foram feitas medições da tensão superficial e de ângulo de contato das caldas com tensiômetro. A tensão superficial foi quantificada aos 5, 15 e 25 segundos após a formação da gota. O ângulo de contato foi medido nos tempos de 5, 15 e 25 segundos, após depósito das gotas sobre as superfícies adaxial e abaxial de folhas de Sida rhombifolia, S. glaziovii e S. cordifolia. Os resultados foram submetidos à análise de variância, pelo teste F, e as médias dos tratamentos, comparadas pelo teste de Tukey (p>0,05). Não houve interação entre os fatores para tensão superficial. Os ângulos de contato de S. cordifolia e S. glaziovii foram menores após a adição da lecitina na face adaxial. A adição dos adjuvantes na calda proporcionou menores ângulos de contato na dosagem de 0,04 + 0,08 kg i.a. ha-1, exceto para S. rhombifolia, cujo ângulo de contato foi menor com a calda sem adjuvante.

ABSTRACT: Droplet spreading on plant surfaces may indicate greater efficiency in herbicide application. The aim of this study was to evaluate surface tension and contact angle of the aminopyralid + fluroxypir herbicide droplets associated with adjuvants on the leaf surface of three species of the genus Sida. The experiment was carried out in a completely randomized design, in a 4x2+1 factorial arrangement, with four replications. Four treatments containing two rates of the herbicide (0.04 + 0.08 kg a.i. ha-1 and 0.08+0.16 kg a.i. ha-1) were evaluated, associated or not with the adjuvants vegetable oil, mineral oil and lecthin; and water was used as a control. Surface tension and contact angle of the syringes were measured with a tensiometer. Surface tension was evaluated at 5, 15 and 25 seconds after droplet formation. Contact angle was measured at 5, 15 and 25 seconds after droplet deposition on the adaxial and abaxial surfaces of Sida rhombifolia, S. glaziovii and S. cordifolia. The results were submitted to analysis of variance by the F-test and the means of the treatments were compared by Tukey’s test (p>0.05). There was no interaction between the factors for surface tension. The contact angles of S. cordifolia and S. glaziovii were lower after addition of lecthin on the adaxial face. The addition of the adjuvants to the spray solution provided lower contact angles at the rate of 0.04 + 0.08 kg a.i. ha-1, except for S. rhombifolia, whose contact angle was lower with the spray solution without adjuvant.

https://doi.org/10.1590/s0100-83582019370100082 524 downloads

Embryonic mortality and abortion in goats caused by ingestion of Poincianella pyramidalis
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Santos, José R.S. dos

; Lopes, José R.G.

; Medeiros, Marcia A.

; Campos, Édipo M.

; Medeiros, Rosane M.T.

; Riet-Correa, Franklin

Pesquisa Veterinária Brasileira

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jul 2018, Volume 38 N. 7 Pages 1259 - 1263

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: O objetivo deste trabalho foi estudar o potencial embriotóxico, abortivo e teratogênico da Poincianella pyramidalis em caprinos. Para tanto foram utilizadas 20 cabras prenhes com 18 dias de gestação, divididas em cinco grupos de quatro animais. Depois da coleta, as folhas de P. pyramidalis era secas a sombra e trituradas. A alimentação diária fornecida aos caprinos foi proporcional a 3% do seu peso vivo, sendo 1% de alimento concentrado e 2% de volumoso. No Grupo 1 (controle), o volumoso fornecido foi apenas feno de Cynodon dactylon (Tifton). Já nos Grupos 2, 3 e 4, 10%, 20% e 80% do volumoso foi substituído por folhas secas e trituradas de P. pyramidalis, respectivamente. No Grupo 5, todo o volumoso foi constituído por P. pyramidalis verde ad libitum, coletadas diariamente. Para o acompanhamento das gestações, exames ultrassonográficos foram realizados duas vezes por semana, durante toda a gestação. As cabras dos Grupos 1, 2 e 3 pariram cabritos normais. Duas cabras no Grupo 4 abortaram, sendo uma com 127 dias de gestação e outra com 90 dias. No grupo 5, três cabras apresentaram morte embrionária no 25º, 30º e 31º dia de gestação e uma cabra abortou no 39º dia de gestação. No presente estudo não foi observada nenhuma malformação. Com esses resultados e considerando a ampla difusão de P. pyramidalis na região semiárida do nordeste Brasileiro sugere-se que esta planta é uma importante causa de perdas reprodutivas na região. Devido a sua alta palatabilidade, recomenda-se evitar a permanência de cabras prenhes em áreas onde ocorre P. pyramidalis.

ABSTRACT: This study aimed to characterize the embryotoxic, teratogenic and abortifacient effect of Poincianella pyramidalis in goats. Twenty pregnant goats with 18 days of gestation were divided into five groups of four animals each. After collection, the leaves of P. pyramidalis were dried in the shade and crushed. The daily feed provided to the goats was equivalent to 3% of their body weight, being 1% concentrated feed and 2% roughage. In Group 1 (control), the provided roughage was Cynodon dactylon (Tifton) hay; in Groups 2, 3 and 4, 10%, 20% and 80% of the C. dactylon roughage was replaced by dry and ground P. pyramidalis, respectively. In Group 5, all the roughage was replaced by green P. pyramidalis ad libitum, collected daily. Ultrasonographic examination was performed twice a week throughout the pregnancy. Goats in Groups 1, 2 and 3, delivered normal kids. Two goats in Group 4 aborted at 127 and 90 days of gestation. In group 5, three goats showed embryonic death at 25, 30 and 31 days of gestation and the other goat aborted at 39 days of pregnancy. Malformations were not observed. It is suggested that P. pyramidalis, which is very common in the semiarid region of northeastern Brazil, should be considered as an important cause of reproductive losses in this area. Due to its high palatability, it is important to avoid the ingestion of P. pyramidalis by pregnant and mating goats.

https://doi.org/10.1590/1678-5150-pvb-5480 1113 downloads

10.

Lipid profile of immunocastrated, castrated male and female pigs
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Caldara, F.R.

; Santos, L.S.

; Santos, C.T.

; Foppa, L.

; Garcia, R.G.

; Nääs, I.A.

; S. Nieto, V.M.O.

Arquivo Brasileiro de Medicina Veterinária e Zootecnia

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jun 2018, Volume 70 N. 3 Pages 1004 - 1008

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A presente pesquisa foi realizada com o objetivo de avaliar os níveis de colesterol, extrato etéreo, perfil de ácidos graxos e o índice aterogênico e trombogênico da gordura intramuscular de suínos machos imunocastrados em relação às fêmeas e aos machos castrados cirurgicamente. Utilizaram-se 45 animais, com peso inicial de 25,2±2,8kg, distribuídos em delineamento inteiramente ao acaso, com três tratamentos (machos castrados, machos e fêmeas imunocastrados) e três repetições de cinco animais cada. Os animais foram abatidos a 90,3±2,7kg. As amostras de Longissimus dorsi foram coletadas, liofilizadas e analisadas quanto ao perfil de ácidos gordos, colesterol e extrato etéreo. Não foram observadas diferenças (P>0,05) para nenhuma das variáveis analisadas entre a gordura intramuscular de machos castrados cirurgicamente, machos imunocastrados e fêmeas. A imunocastração não alterou os níveis intramusculares de extrato etéreo, colesterol, composição de ácidos graxos ou o índice aterogênico e trombogênico do Longissimus dorsi.

https://doi.org/10.1590/1678-4162-10062 831 downloads

11.

Brazilian legislation on genetic heritage harms Biodiversity Convention goals and threatens basic biology research and education
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ALVES, RUY JOSÉ V.

; WEKSLER, MARCELO

; OLIVEIRA, JOÃO A.

; BUCKUP, PAULO A.

; POMBAL JR., JOSÉ P.

; SANTANA, HÉLCIO R.G.

; PERACCHI, ADRIANO LÚCIO

; KELLNER, ALEXANDER W.A.

; ALEIXO, ALEXANDRE

; LANGGUTH, ALFREDO

; ALMEIDA, ALZIRA MARIA P. DE

; ALBERNAZ, ANA LUISA

; RIBAS, CAMILA C.

; ZILBERBERG, CARLA

; GRELLE, CARLOS EDUARDO V.

; ROCHA, CARLOS F.D.

; LAMAS, CARLOS JOSÉ E.

; HADDAD, CÉLIO F.B.

; BONVICINO, CIBELE R.

; PRADO, CYNTHIA P.A.

; LIMA, DANIELA O. DE

; ROSSA-FERES, DENISE C.

; SANTOS, FABRÍCIO R. DOS

; SALIMENA, FÁTIMA REGINA G.

; PERINI, FERNANDO A.

; BOCKMANN, FLÁVIO A.

; FRANCO, FRANCISCO LUÍS

; GIUDICE, GISELE M.L. DEL

; COLLI, GUARINO R.

; VIEIRA, IMA CÉLIA G.

; MARINHO-FILHO, JADER

; WERNECK, JANE M.C.F.

; SANTOS, JORGE A.D. DOS

; NASCIMENTO, JORGE LUIZ DO

; NESSIMIAN, JORGE LUIZ

; CORDEIRO, JOSÉ LUIS P.

; CLARO, KLEBER DEL

; SALLES, LEANDRO O.

; CASATTI, LILIAN

; PY-DANIEL, LUCIA HELENA R.

; SILVEIRA, LUÍS FÁBIO

; TOLEDO, LUÍS FELIPE

; OLIVEIRA, LUIZ F. DE

; MALABARBA, LUIZ ROBERTO

; SILVA, MARCELO D. DA

; COURI, MÁRCIA S.

; MARTINS, MÁRCIO

; TAVARES, MARCOS D.S.

; SOBRAL, MARCOS EDUARDO G.

; VIEIRA, MARCUS VINÍCIUS

; OLIVEIRA, MARIA DE LOURDES A.

; PINNA, MÁRIO DE

; HOPKINS, MICHAEL J.G.

; SOLÉ, MIRCO

; MENEZES, NAÉRCIO A.

; PASSOS, PAULO

; D’ANDREA, PAULO SERGIO

; PINTO, PEDRO C.E.A.

; VIANA, PEDRO L.

; TOLEDO, PETER M.

; REIS, ROBERTO E.

; VILELA, ROBERTO

; BASTOS, ROGÉRIO P.

; COLLEVATTI, ROSANE G.

; CERQUEIRA, RUI

; CASTROVIEJO-FISHER, SANTIAGO

; CARAMASCHI, ULISSES

Anais da Academia Brasileira de Ciências

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apr 2018, Volume 90 N. 2 Pages 1279 - 1284

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/0001-3765201820180460 7311 downloads

12.

Embryonic death and abortion in goats caused by ingestion of Amorimia septentrionalis
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Silva, Layze C.A. da

; Pessoa, Danielle A. do N.

; Lopes, José R.G.

; Santos, José R.S. dos

; Olinda, Robério G.

; Riet-Correa, Franklin

Pesquisa Veterinária Brasileira

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dec 2017, Volume 37 N. 12 Pages 1401 - 1404

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Amorimia spp. são plantas que contém monofluoroacetato de sódio (MFA), responsáveis por causar morte súbita em ruminantes. Em estudo prévio, Amorimia rigida causou aborto em uma de cinco ovelhas prenhas que receberam a planta, sugerindo que pode causar perdas reprodutivas. Este trabalho teve como objetivo estudar os efeitos embriotóxicos e fetotóxicos de Amorimia septentrionalis em caprinos na região semi-árida nordestina brasileira. Os efeitos de A. septentrionalis na prenhez foram estudados em 16 cabras, divididos em quatro grupos de acordo com seu período gestacional. Nos grupos 1, 2 e 3 a administração de A. septentrionalis foi diária, na dose de 5g de folhas por kg de peso corporal, iniciada nos dias 18, 36 e 93 da gestação, respectivamente. As cabras do grupo 4 não ingeriram a planta. Quando as cabras apresentavam sinais severos de intoxicação suspendia-se a administração da planta. Os grupos 1, 2 e 3 ingeriram a planta por 7,25±2,87, 9,25±2,21 e 12,50±0,57 dias, respectivamente. Todas as cabras se recuperaram 7-12 dias após o final da administração da planta. No grupo 1, todas as cabras apresentaram quadros de mortalidade embrionária 6,25±3,59 dias após o término da ingestão da planta. No grupo 2, três cabras abortaram aos 53, 54 e 78 dias de gestação. Duas cabras do Grupo 3 deram à luz normalmente e as outras duas abortaram aos 114 e 111 dias de gestação. Conclui-se que Amorimia septentrionalis é uma planta que contém monofluoroacetato de sódio e pode ocasionar mortes embrionárias e abortos em cabras que ingerem doses não letais da planta.

ABSTRACT: Amorimia spp. are sodium monofluoroacetate (MFA) containing plants causing sudden death in ruminants. In a previous study, Amorimia rigida caused abortion in one of the five pregnant sheep that received the plant suggesting that it may cause reproductive losses. This work aimed to study the embryotoxic and fetotoxic effects of Amorimia septentrionalis in goats in the Brazilian northeastern semi-arid region. The effects of A. septentrionalis on pregnancy were studied in 16 goats, divided into four groups according to their gestational period. In Groups 1, 2 and 3 the administration of A. septentrionalis at the daily dose of 5g of leaves per kg body weight was started on the 18th, 36th and 93th days of gestation, respectively. Goats from Group 4 did not ingest the plant. When the goats presented severe signs of poisoning the administration of the plant was suspended. Groups 1, 2 and 3 ingested the plant for 7.25±2.87, 9.25±2.21 and 12.50±0.57 days, respectively. All the goats recovered 7-12 days after the end of the administration of the plant. In Group 1, all the goats had embryonic death 6.25±3.59 days after the end of the ingestion of the plant. In Group 2, three goats aborted at 53, 54 and 78 days of gestation. Two goats from Group 3 gave birth normally and the other two aborted at 114 and 111 days of gestation. It is concluded that Amorimia septentrionalis is a sodium monofluoracetate-containing plant that causes embryonic deaths and abortions in goats that ingest non-lethal doses of the plant.

https://doi.org/10.1590/s0100-736x2017001200007 3186 downloads

13.

Alkaloids isolated from the leaves of atemoya (Annona cherimola × Annona squamosa)
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Rabêlo, Suzana V.

; Costa, Emmanoel V.

; Barison, Andersson

; Dutra, Lívia M.

; Nunes, Xirley P.

; Tomaz, José C.

; Oliveira, Gibson G.

; Lopes, Norberto P.

; Santos, Maria de Fátima C.

; Almeida, Jackson R.G. da Silva

Revista Brasileira de Farmacognosia

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aug 2015, Volume 25 N. 4 Pages 419 - 421

Abstract: En | Text: En | PDF: En

AbstractAtemoya is an interspecific annonaceous hybrid between Annona cherimola Mill. and Annona squamosa L. Its phytochemical investigation led to seven alkaloids, including two aporphine (anonaine and asimilobine), three oxoaporphine (lanuginosine, liriodenine and lysicamine) and two proaporphine (pronuciferine and stepharine). These alkaloids were identified by a series of spectrometric methods, mainly MS and NMR (1D and 2D), as well as by comparison with literature data. Our findings showed that this species is an important source of aporphine alkaloids and have high relationship with other Annona species.

https://doi.org/10.1016/j.bjp.2015.07.006 2362 downloads

14.

Growing knowledge: an overview of Seed Plant diversity in Brazil
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Zappi, Daniela C.

; Filardi, Fabiana L. Ranzato

; Leitman, Paula

; Souza, Vinícius C.

; Walter, Bruno M.T.

; Pirani, José R.

; Morim, Marli P.

; Queiroz, Luciano P.

; Cavalcanti, Taciana B.

; Mansano, Vidal F.

; Forzza, Rafaela C.

; Abreu, Maria C.

; Acevedo-Rodríguez, Pedro

; Agra, Maria F.

; Almeida Jr., Eduardo B.

; Almeida, Gracineide S.S.

; Almeida, Rafael F.

; Alves, Flávio M.

; Alves, Marccus

; Alves-Araujo, Anderson

; Amaral, Maria C.E.

; Amorim, André M.

; Amorim, Bruno

; Andrade, Ivanilza M.

; Andreata, Regina H.P.

; Andrino, Caroline O.

; Anunciação, Elisete A.

; Aona, Lidyanne Y.S.

; Aranguren, Yani

; Aranha Filho, João L.M.

; Araújo, Andrea O.

; Araújo, Ariclenes A.M.

; Araújo, Diogo

; Arbo, María M.

; Assis, Leandro

; Assis, Marta C.

; Assunção, Vivian A.

; Athiê-Souza, Sarah M.

; Azevedo, Cecilia O.

; Baitello, João B.

; Barberena, Felipe F.V.A.

; Barbosa, Maria R.V.

; Barros, Fábio

; Barros, Lucas A.V.

; Barros, Michel J.F.

; Baumgratz, José F.A.

; Bernacci, Luis C.

; Berry, Paul E.

; Bigio, Narcísio C.

; Biral, Leonardo

; Bittrich, Volker

; Borges, Rafael A.X.

; Bortoluzzi, Roseli L.C.

; Bove, Cláudia P.

; Bovini, Massimo G.

; Braga, João M.A.

; Braz, Denise M.

; Bringel Jr., João B.A.

; Bruniera, Carla P.

; Buturi, Camila V.

; Cabral, Elza

; Cabral, Fernanda N.

; Caddah, Mayara K.

; Caires, Claudenir S.

; Calazans, Luana S.B.

; Calió, Maria F.

; Camargo, Rodrigo A.

; Campbell, Lisa

; Canto-Dorow, Thais S.

; Carauta, Jorge P.P.

; Cardiel, José M.

; Cardoso, Domingos B.O.S.

; Cardoso, Leandro J.T.

; Carneiro, Camila R.

; Carneiro, Cláudia E.

; Carneiro-Torres, Daniela S.

; Carrijo, Tatiana T.

; Caruzo, Maria B.R.

; Carvalho, Maria L.S.

; Carvalho-Silva, Micheline

; Castello, Ana C.D.

; Cavalheiro, Larissa

; Cervi, Armando C.

; Chacon, Roberta G.

; Chautems, Alain

; Chiavegatto, Berenice

; Chukr, Nádia S.

; Coelho, Alexa A.O.P.

; Coelho, Marcus A.N.

; Coelho, Rubens L.G.

; Cordeiro, Inês

; Cordula, Elizabeth

; Cornejo, Xavier

; Côrtes, Ana L.A.

; Costa, Andrea F.

; Costa, Fabiane N.

; Costa, Jorge A.S.

; Costa, Leila C.

; Costa-e-Silva, Maria B.

; Costa-Lima, James L.

; Cota, Maria R.C.

; Couto, Ricardo S.

; Daly, Douglas C.

; De Stefano, Rodrigo D.

; De Toni, Karen

; Dematteis, Massimiliano

; Dettke, Greta A.

; Di Maio, Fernando R.

; Dórea, Marcos C.

; Duarte, Marília C.

; Dutilh, Julie H.A.

; Dutra, Valquíria F.

; Echternacht, Lívia

; Eggers, Lilian

; Esteves, Gerleni

; Ezcurra, Cecilia

; Falcão Junior, Marcus J.A.

; Feres, Fabíola

; Fernandes, José M.

; Ferreira, D.M.C.

; Ferreira, Fabrício M.

; Ferreira, Gabriel E.

; Ferreira, Priscila P.A.

; Ferreira, Silvana C.

; Ferrucci, Maria S.

; Fiaschi, Pedro

; Filgueiras, Tarciso S.

; Firens, Marcela

; Flores, Andreia S.

; Forero, Enrique

; Forster, Wellington

; Fortuna-Perez, Ana P.

; Fortunato, Reneé H.

; Fraga, Cléudio N.

; França, Flávio

; Francener, Augusto

; Freitas, Joelcio

; Freitas, Maria F.

; Fritsch, Peter W.

; Furtado, Samyra G.

; Gaglioti, André L.

; Garcia, Flávia C.P.

; Germano Filho, Pedro

; Giacomin, Leandro

; Gil, André S.B.

; Giulietti, Ana M.

; A.P.Godoy, Silvana

; Goldenberg, Renato

; Gomes da Costa, Géssica A.

; Gomes, Mário

; Gomes-Klein, Vera L.

; Gonçalves, Eduardo Gomes

; Graham, Shirley

; Groppo, Milton

; Guedes, Juliana S.

; Guimarães, Leonardo R.S.

; Guimarães, Paulo J.F.

; Guimarães, Elsie F.

; Gutierrez, Raul

; Harley, Raymond

; Hassemer, Gustavo

; Hattori, Eric K.O.

; Hefler, Sonia M.

; Heiden, Gustavo

; Henderson, Andrew

; Hensold, Nancy

; Hiepko, Paul

; Holanda, Ana S.S.

; Iganci, João R.V.

; Imig, Daniela C.

; Indriunas, Alexandre

; Jacques, Eliane L.

; Jardim, Jomar G.

; Kamer, Hiltje M.

; Kameyama, Cíntia

; Kinoshita, Luiza S.

; Kirizawa, Mizué

; Klitgaard, Bente B.

; Koch, Ingrid

; Koschnitzke, Cristiana

; Krauss, Nathália P.

; Kriebel, Ricardo

; Kuntz, Juliana

; Larocca, João

; Leal, Eduardo S.

; Lewis, Gwilym P.

; Lima, Carla T.

; Lima, Haroldo C.

; Lima, Itamar B.

; Lima, Laíce F.G.

; Lima, Laura C.P.

; Lima, Leticia R.

; Lima, Luís F.P.

; Lima, Rita B.

; Lírio, Elton J.

; Liro, Renata M.

; Lleras, Eduardo

; Lobão, Adriana

; Loeuille, Benoit

; Lohmann, Lúcia G.

; Loiola, Maria I.B.

; Lombardi, Julio A.

; Longhi-Wagner, Hilda M.

; Lopes, Rosana C.

; Lorencini, Tiago S.

; Louzada, Rafael B.

; Lovo, Juliana

; Lozano, Eduardo D.

; Lucas, Eve

; Ludtke, Raquel

; Luz, Christian L.

; Maas, Paul

; Machado, Anderson F.P.

; Macias, Leila

; Maciel, Jefferson R.

; Magenta, Mara A.G.

; Mamede, Maria C.H.

; Manoel, Evelin A.

; Marchioretto, Maria S.

; Marques, Juliana S.

; Marquete, Nilda

; Marquete, Ronaldo

; Martinelli, Gustavo

; Martins da Silva, Regina C.V.

; Martins, Ângela B.

; Martins, Erika R.

; Martins, Márcio L.L.

; Martins, Milena V.

; Martins, Renata C.

; Matias, Ligia Q.

; Maya-L., Carlos A.

; Mayo, Simon

; Mazine, Fiorella

; Medeiros, Debora

; Medeiros, Erika S.

; Medeiros, Herison

; Medeiros, João D.

; Meireles, José E.

; Mello-Silva, Renato

; Melo, Aline

; Melo, André L.

; Melo, Efigênia

; Melo, José I.M.

; Menezes, Cristine G.

; Menini Neto, Luiz

; Mentz, Lilian A.

; Mezzonato, A.C.

; Michelangeli, Fabián A.

; Milward-de-Azevedo, Michaele A.

; Miotto, Silvia T.S.

; Miranda, Vitor F.O.

; Mondin, Cláudio A.

; Monge, Marcelo

; Monteiro, Daniele

; Monteiro, Raquel F.

; Moraes, Marta D.

; Moraes, Pedro L.R.

; Mori, Scott A.

; Mota, Aline C.

; Mota, Nara F.O.

; Moura, Tania M.

; Mulgura, Maria

; Nakajima, Jimi N.

; Nardy, Camila

; Nascimento Júnior, José E.

; Noblick, Larry

; Nunes, Teonildes S.

; O'Leary, Nataly

; Oliveira, Arline S.

; Oliveira, Caetano T.

; Oliveira, Juliana A.

; Oliveira, Luciana S.D.

; Oliveira, Maria L.A.A.

; Oliveira, Regina C.

; Oliveira, Renata S.

; Oliveira, Reyjane P.

; Paixão-Souza, Bruno

; Parra, Lara R.

; Pasini, Eduardo

; Pastore, José F.B.

; Pastore, Mayara

; Paula-Souza, Juliana

; Pederneiras, Leandro C.

; Peixoto, Ariane L.

; Pelissari, Gisela

; Pellegrini, Marco O.O.

; Pennington, Toby

; Perdiz, Ricardo O.

; Pereira, Anna C.M.

; Pereira, Maria S.

; Pereira, Rodrigo A.S.

; Pessoa, Clenia

; Pessoa, Edlley M.

; Pessoa, Maria C.R.

; Pinto, Luiz J.S.

; Pinto, Rafael B.

; Pontes, Tiago A.

; Prance, Ghillean T.

; Proença, Carolyn

; Profice, Sheila R.

; Pscheidt, Allan C.

; Queiroz, George A.

; Queiroz, Rubens T.

; Quinet, Alexandre

; Rainer, Heimo

; Ramos, Eliana

; Rando, Juliana G.

; Rapini, Alessandro

; Reginato, Marcelo

; Reis, Ilka P.

; Reis, Priscila A.

; Ribeiro, André R.O.

; Ribeiro, José E.L.S.

; Riina, Ricarda

; Ritter, Mara R.

; Rivadavia, Fernando

; Rocha, Antônio E.S.

; Rocha, Maria J.R.

; Rodrigues, Izabella M.C.

; Rodrigues, Karina F.

; Rodrigues, Rodrigo S.

; Rodrigues, Vinícius T.

; Rodrigues, William

; Romaniuc Neto, Sérgio

; Romão, Gerson O.

; Romero, Rosana

; Roque, Nádia

; Rosa, Patrícia

; Rossi, Lúcia

; Sá, Cyl F.C.

; Saavedra, Mariana M.

; Saka, Mariana

; Sakuragui, Cássia M.

; Salas, Roberto M.

; Sales, Margareth F.

; Salimena, Fatima R.G.

; Sampaio, Daniela

; Sancho, Gisela

; Sano, Paulo T.

; Santos, Alessandra

; Santos, Élide P.

; Santos, Juliana S.

; Santos, Marianna R.

; Santos-Gonçalves, Ana P.

; Santos-Silva, Fernanda

; São-Mateus, Wallace

; Saraiva, Deisy P.

; Saridakis, Dennis P.

; Sartori, Ângela L.B.

; Scalon, Viviane R.

; Schneider, Ângelo

; Sebastiani, Renata

; Secco, Ricardo S.

; Senna, Luisa

; Senna-Valle, Luci

; Shirasuna, Regina T.

; Silva Filho, Pedro J.S.

; Silva, Anádria S.

; Silva, Christian

; Silva, Genilson A.R.

; Silva, Gisele O.

; Silva, Márcia C.R.

; Silva, Marcos J.

; Silva, Otávio L.M.

; Silva, Rafaela A.P.

; Silva, Saura R.

; Silva, Tania R.S.

; Silva-Gonçalves, Kelly C.

; Silva-Luz, Cíntia L.

; Simão-Bianchini, Rosângela

; Simões, André O.

; Simpson, Beryl

; Siniscalchi, Carolina M.

; Siqueira Filho, José A.

; Siqueira, Carlos E.

; Siqueira, Josafá C.

; Smith, Nathan P.

; Snak, Cristiane

; Soares Neto, Raimundo L.

; Soares, Kelen P.

; Soares, Marcos V.B.

; Soares, Maria L.

; Soares, Polyana N.

; Sobral, Marcos

; Sodré, Rodolfo C.

; Somner, Genise V.

; Sothers, Cynthia A.

; Sousa, Danilo J.L.

; Souza, Elnatan B.

; Souza, Élvia R.

; Souza, Marcelo

; Souza, Maria L.D.R.

; Souza-Buturi, Fátima O.

; Spina, Andréa P.

; Stapf, María N.S.

; Stefano, Marina V.

; Stehmann, João R.

; Steinmann, Victor

; Takeuchi, Cátia

; Taylor, Charlotte M.

; Taylor, Nigel P.

; Teles, Aristônio M.

; Temponi, Lívia G.

; Terra-Araujo, Mário H.

; Thode, Veronica

; Thomas, W.Wayt

; Tissot-Squalli, Mara L.

; Torke, Benjamin M.

; Torres, Roseli B.

; Tozzi, Ana M.G.A.

; Trad, Rafaela J.

; Trevisan, Rafael

; Trovó, Marcelo

; Valls, José F.M.

; Vaz, Angela M.S.F.

; Versieux, Leonardo

; Viana, Pedro L.

; Vianna Filho, Marcelo D.M.

; Vieira, Ana O.S.

; Vieira, Diego D.

; Vignoli-Silva, Márcia

; Vilar, Thaisa

; Vinhos, Franklin

; Wallnöfer, Bruno

; Wanderley, Maria G.L.

; Wasshausen, Dieter

; Watanabe, Maurício T.C.

; Weigend, Maximilian

; Welker, Cassiano A.D.

; Woodgyer, Elizabeth

; Xifreda, Cecilia C.

; Yamamoto, Kikyo

; Zanin, Ana

; Zenni, Rafael D.

; Zickel, Carmem S

Rodriguésia

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2015, Volume 66 N. 4 Pages 1085 - 1113

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Um levantamento atualizado das plantas com sementes e análises relevantes acerca desta biodiversidade são apresentados. Este trabalho se iniciou em 2010 com a publicação do Catálogo de Plantas e Fungos e, desde então vem sendo atualizado por mais de 430 especialistas trabalhando online. O Brasil abriga atualmente 32.086 espécies nativas de Angiospermas e 23 espécies nativas de Gimnospermas e estes novos dados mostram um aumento de 3% da riqueza em relação a 2010. A Amazônia é o Domínio Fitogeográfico com o maior número de espécies de Gimnospermas, enquanto que a Floresta Atlântica possui a maior riqueza de Angiospermas. Houve um crescimento considerável no número de espécies e nas taxas de endemismo para a maioria dos Domínios (Caatinga, Cerrado, Floresta Atlântica, Pampa e Pantanal), com exceção da Amazônia que apresentou uma diminuição de 2,5% de endemicidade. Entretanto, a maior parte das plantas com sementes que ocorrem no Brasil (57,4%) é endêmica deste território. A proporção de formas de vida varia de acordo com os diferentes Domínios: árvores são mais expressivas na Amazônia e Floresta Atlântica do que nos outros biomas, ervas são dominantes no Pampa e as lianas apresentam riqueza expressiva na Amazônia, Floresta Atlântica e Pantanal. Este trabalho não só quantifica a biodiversidade brasileira, mas também indica as lacunas de conhecimento e o desafio a ser enfrentado para a conservação desta flora.

Abstract An updated inventory of Brazilian seed plants is presented and offers important insights into the country's biodiversity. This work started in 2010, with the publication of the Plants and Fungi Catalogue, and has been updated since by more than 430 specialists working online. Brazil is home to 32,086 native Angiosperms and 23 native Gymnosperms, showing an increase of 3% in its species richness in relation to 2010. The Amazon Rainforest is the richest Brazilian biome for Gymnosperms, while the Atlantic Rainforest is the richest one for Angiosperms. There was a considerable increment in the number of species and endemism rates for biomes, except for the Amazon that showed a decrease of 2.5% of recorded endemics. However, well over half of Brazillian seed plant species (57.4%) is endemic to this territory. The proportion of life-forms varies among different biomes: trees are more expressive in the Amazon and Atlantic Rainforest biomes while herbs predominate in the Pampa, and lianas are more expressive in the Amazon, Atlantic Rainforest, and Pantanal. This compilation serves not only to quantify Brazilian biodiversity, but also to highlight areas where there information is lacking and to provide a framework for the challenge faced in conserving Brazil's unique and diverse flora.

https://doi.org/10.1590/2175-7860201566411 33340 downloads

15.

Scintigraphy in postoperative follow-up of osteosynthesis of the femur with a bridge plate associated with an intramedullary pin in rabbits
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Borges, N.F.

; Serakides, R.

; Santos, R.G.

; Diniz, S.O.F.

; Cardoso, V.N.

; Ucros, N.S.

; Torres, R.C.S.

; Cardoso, S.V.

; Rezende, C.M.F.

Arquivo Brasileiro de Medicina Veterinária e Zootecnia

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aug 2013, Volume 65 N. 4 Pages 1065 - 1074

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A cintilografia foi empregada no acompanhamento da consolidação de osteotomia experimental do fêmur após osteossíntese com placa em ponte associada ao pino intramedular. Foram usados sete coelhos machos, raça Nova Zelândia, com massa corporal de 3,5kg e idade média de quatro meses. A cintilografia óssea trifásica com metilenodifosfonato marcado com tecnécio-99m (MDP-99mTc) foi obtida antes e após a cirurgia, e nos dias 20, 50 e 90 do pós-operatório.O índice de atividade (IA) foi calculado por meio do quociente da média do número de contagens na região da osteotomia pela média do número de contagens na região correspondente, no membro contralateral normal. Paralelamente ao estudo cintilográfico, foram realizadas radiografias antes dos procedimentos cirúrgicos e aos 15, 30, 45, 60 e 90 dias após, para acompanhamento do processo de cura óssea. Encontrou-se relação direta entre o índice de atividade e a evolução do processo de consolidação óssea na avaliação cintilográfica sequencial ao longo do período de observação. A cintilografia óssea trifásica permite acompanhar o metabolismo ósseo, avaliar e mensurar a vascularização e perfusão tecidual. As imagens obtidas na fase de pool sanguíneo e na fase óssea são as mais adequadas para avaliação do metabolismo ósseo. A placa em ponte associada com o pino intramedular promove osteossíntese com estabilidade suficiente para permitir a consolidação ossea.

The objective of this work was to monitor the consolidation of the femur after osteosynthesis with a bridge plate associated with the intramedullary pin using scintigraphy. We used seven New Zealand breed male rabbits, at 4 months of age, with a mean weight of 3.5 kg. We performed a three-phase bone scintigraphy with technetium-labeled methylene diphosphonate (99mTc-MDP) before and after surgery, and 20, 50 and 90 days postoperatively. The activity index (AI) was calculated by dividing the average number of uptake counts in the region of the osteotomy by the average number of counts in the corresponding region in the contralateral limb. Radiography was performed before surgery, after surgery, and 15, 30, 45, 60 and 90 days postoperatively. We found a direct relationship between the activity index and progress of bone scintigraphy in the evaluation sequence over the period of observation. Scintigraphy allows monitoring of bone metabolism and measurement of vascularization and/or bone or tissue perfusion. The images obtained in the blood pool and static phases are the most appropriate for assessing bone metabolism in the context of this study. The bridge plate associated with the intramedullary pin promotes osteosynthesis with sufficient stability to allow bone consolidation.

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