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ABSTRACT BACKGROUND: The Kerlan-Jobe Orthopedic Clinic (KJOC) Shoulder and Elbow Score is commonly used to assess the functional status of athletes with conditions affecting the shoulder and elbow. However, a Brazilian Portuguese version of the KJOC questionnaire is currently unavailable. OBJECTIVES: This study aimed to develop a Brazilian Portuguese version of the KJOC questionnaire. DESIGN AND SETTING: This translation and cultural adaptation study was conducted at the Federal University of Paraíba, Brazil. METHODS: The procedures adopted in this study followed guidelines recommending translation by two independent translators, synthesis of the translations, back-translation performed by two native English-speaking translators, analysis by an expert committee, and pre-testing. The Portuguese version was tested with 32 athletes to assess their understanding of the assessment tool. Items were deemed adequate if they were understood by at least 90% of the athletes. RESULTS: The terms and expressions of some original items were modified to achieve better comprehensibility in the Brazilian context. No further modifications were necessary after the pre-test; all terms were comprehensible to over 90% of athletes. CONCLUSION: The translation and cultural adaptation of the KJOC questionnaire into Portuguese were completed, resulting in a Brazilian version of the scale. Further studies are needed to evaluate the reliability and validity of this scale. BACKGROUND KerlanJobe Kerlan Jobe (KJOC elbow However unavailable OBJECTIVES SETTING Paraíba Brazil METHODS translators translations backtranslation back Englishspeaking English speaking committee pretesting. pretesting pre testing. testing pre-testing 3 tool 90 RESULTS context pretest test pre-test CONCLUSION completed scale 9

https://doi.org/10.1590/1516-3180.2023.0139.03072024

Psychometric properties and reliability of the Brazilian version of Parent Attitudes about Childhood Vaccine (PACV-BR) PACVBR PACV BR (PACV-BR
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Santos Júnior, Claudio José dos

; Silva, Maria Rosa da

; Costa, Paulo José Medeiros de Souza

Revista Paulista de Pediatria

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2024, Volume 42 elocation e2023019

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Avaliar as propriedades psicométricas e a confiabilidade da versão brasileira do instrumento Parent Attitudes about Childhood Vaccine (PACV-BR). Métodos: A amostra incluiu 110 pais de crianças de até dois anos atendidas em Unidades Básicas de Saúde da Família. A consistência interna e a validade fatorial do instrumento foram avaliadas, respectivamente, pelo alfa de Cronbach e pela análise fatorial exploratória (EFA). A confiabilidade teste-reteste foi avaliada pelo coeficiente de correlação intraclasse (ICC). Resultados: Os resultados da AFE indicaram adequação estrutural do PACV-BR (15 itens e dois fatores). A confiabilidade indicou valores de alfa de Cronbach entre 0,715 e 0,854 para os itens, de 0,918 para o instrumento como um todo, de 0,877 para o fator 1 e de 0,825 para o fator 2, além de ICC de 0,984. Conclusões: O PACV-BR apresentou evidências de validade de construto e confiabilidade. Objetivo PACVBR. PACVBR PACV BR . (PACV-BR) Métodos 11 Família avaliadas respectivamente EFA. EFA (EFA) testereteste teste reteste ICC. (ICC) Resultados 15 (1 fatores. fatores fatores) 0715 0 715 0,71 0854 854 0,85 0918 918 0,91 todo 0877 877 0,87 0825 825 0,82 2 0984 984 0,984 Conclusões (PACV-BR (EFA (ICC ( 071 71 0,7 085 85 0,8 091 91 0,9 087 87 082 82 098 98 0,98 07 7 0, 08 8 09 9

ABSTRACT Objective: To evaluate the psychometric properties and reliability of the Brazilian version of the tool Parent Attitudes about Childhood Vaccine (PACV-BR). Methods: The sample included 110 parents of children up to two years old served by Family Health Basic Units. The tool's internal consistency and factor validity were respectively assessed by Cronbach's alpha and exploratory factor analysis (EFA). The test-retest reliability was assessed by the intraclass correlation coefficient (ICC). Results: The EFA results indicated a proper structural adequacy of the PACV-BR (15 items and two factors). The reliability generated Cronbach's alpha values between 0.715 and 0.854 for the items, of 0.918 for the tool as a whole, of 0.877 for factor 1 and of 0.825 for factor 2, in addition to an ICC of 0.984. Conclusions: The PACV-BR showed evidence of construct validity and reliability. Objective PACVBR. PACVBR PACV BR . (PACV-BR) Methods 11 Units tools s Cronbachs Cronbach EFA. (EFA) testretest test retest ICC. (ICC) Results 15 (1 factors. factors factors) 0715 0 715 0.71 0854 854 0.85 0918 918 0.91 whole 0877 877 0.87 0825 825 0.82 2 0984 984 0.984 Conclusions (PACV-BR (EFA (ICC ( 071 71 0.7 085 85 0.8 091 91 0.9 087 87 082 82 098 98 0.98 07 7 0. 08 8 09 9

https://doi.org/10.1590/1984-0462/2024/42/2023019

Evaluation of the efficacy and safety of cannabidiol-rich cannabis extract in children with autism spectrum disorder: randomized, double-blind, and placebo-controlled clinical trial cannabidiolrich cannabidiol rich disorder randomized doubleblind, doubleblind double blind, blind double-blind placebocontrolled placebo controlled
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Silva Junior, Estácio Amaro da

; Medeiros, Wandersonia Moreira Brito

; Santos, João Paulo Mendes dos

; Sousa, João Marçal Medeiros de

; Costa, Filipe Barbosa da

; Pontes, Katiúscia Moreira

; Borges, Thaís Cavalcanti

; Neto Segundo, Carlos Espínola

; Andrade e Silva, Ana Hermínia

; Nunes, Eliane Lima Guerra

; Alves, Nelson Torro

; Rosa, Marine Diniz da

; Albuquerque, Katy Lísias Gondim Dias de

Trends in Psychiatry and Psychotherapy

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2024, Volume 46 elocation e20210396

Abstract: En | Text: En | PDF: En

Abstract Objective Autism spectrum disorder (ASD) is characterized by persistent deficits in social communication and social interaction and by restricted and repetitive patterns of behavior. Some studies have shown that substances derived from Cannabis sativa improve the quality of life of children with ASD without causing serious adverse effects, thus providing an alternative therapeutic option. The objective of this study was to evaluate the efficacy and safety of a cannabis extract rich in cannabidiol (CBD) in children with ASD. Methods In this randomized, double-blind, placebo-controlled clinical trial, 60 children, aged from 5 to 11 years, were selected and divided into two groups: the treatment group, which received the CBD-rich cannabis extract, and the control group, which received the placebo. They both used their respective products for a period of 12 weeks. Statistical analysis was done by two-factor mixed analysis of variance (two-way ANOVA). Results Significant results were found for social interaction (F1,116 = 14.13, p = 0.0002), anxiety (F1,116 = 5.99, p = 0.016), psychomotor agitation (F1,116 = 9.22, p = 0.003), number of meals a day (F1,116 = 4.11, p = 0.04), and concentration (F1,48 = 6.75, p = 0.01), the last of which was only significant in mild ASD cases. Regarding safety, it was found that only three children in the treatment group (9.7%) had adverse effects, namely dizziness, insomnia, colic, and weight gain. Conclusion CBD-rich cannabis extract was found to improve one of the diagnostic criteria for ASD (social interaction), as well as features that often co-exist with ASD, and to have few serious adverse effects. (ASD behavior effects option CBD (CBD randomized doubleblind, doubleblind double blind, blind double-blind placebocontrolled placebo controlled trial 6 1 years groups CBDrich weeks twofactor factor twoway way ANOVA. ANOVA . ANOVA) F1,116 F1116 F F1 116 (F1,11 1413 14 13 14.13 0.0002, 00002 0.0002 , 0 0002 0.0002) 599 99 5.99 0.016, 0016 0.016 016 0.016) 922 9 22 9.22 0.003, 0003 0.003 003 0.003) 411 4 4.11 0.04, 004 0.04 04 0.04) F1,48 F148 48 (F1,4 675 75 6.75 0.01, 001 0.01 01 0.01) cases 9.7% 97 7 (9.7% dizziness insomnia colic gain interaction, interaction) coexist co exist F1,11 F111 (F1,1 141 14.1 0000 0.000 000 59 5.9 92 2 9.2 0.00 00 41 4.1 0.0 F1,4 F14 (F1, 67 6.7 9.7 (9.7 F1,1 F11 14. 5. 9. 4. 0. F1, (F1 6. (9. (F (9 (

https://doi.org/10.47626/2237-6089-2021-0396

Biochemical-functional differences between reproductive and non-reproductive males of Procambarus clarkii (Girard, 1852) Biochemicalfunctional Biochemical functional nonreproductive non Girard, Girard (Girard 1852 185 18 1
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Valgas, Artur Antunes Navarro

; Wingen, Natália Medeiros de Albulquerque

; Santos, Sarah Helen Dias dos

; Oliveira, Guendalina Turcato

; Araujo, Paula Beatriz

Nauplius

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2024, Volume 32 elocation e20240521

Abstract: En | Text: En | PDF: En

Abstract Intermediate metabolism and oxidative balance markers help to better understand environmental dynamics and how they influence the physiological patterns of organisms. Procambarus clarkii (Girard, 1852), a crayfish native to the United States of America and Mexico, represents an appealing case study for understanding invasive species’ metabolic dynamics. This species has sexual dimorphism and two male morphotypes: reproductive (M1) and non-reproductive (M2). We evaluated the seasonal variations of biomarkers in M1 and M2 males, collected in each season of 2016 at Parque Alfredo Volpi (São Paulo, Brazil). Hemolymph, hepatopancreas and abdominal muscle samples were extracted to determine markers of intermediate metabolism, oxidative balance, the hepatosomatic index and the stomach repletion degree. The results showed differences between the two male morphotypes. M1 showed a predominance of medium to full stomachs throughout the year, with an allocation of energetic substrates mainly used in reproduction (gametogenesis and reproductive behaviors). They also presented increased lipoperoxidation, SOD and GST activities. M2, on the other hand, had a lower capacity to allocate energy reserves in the period leading up to and during reproduction, which may be associated with a lower degree of gastric repletion. However, M2 maintained alternating antioxidant strategies that helped preserve low levels of lipoperoxidation in the hepatopancreas throughout the year. This pattern observed for the degree of gastric repletion indicates an intraspecific competition between the categories of males, which, together with the profile of energy reserve usage, seems decisive for M2 to reproduce. organisms Girard, Girard (Girard 1852, 1852 , 1852) Mexico morphotypes M (M1 nonreproductive non M2. . (M2) males 201 São Paulo Brazil. Brazil Brazil) Hemolymph year gametogenesis behaviors. behaviors behaviors) activities hand However usage reproduce 185 (M (M2 20 18 2 1

https://doi.org/10.1590/2358-2936e20240521

Diretriz de Tomografia Computadorizada e Ressonância Magnética Cardiovascular da Sociedade Brasileira de Cardiologia e do Colégio Brasileiro de Radiologia – 2024 202 20 2
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Magalhães, Tiago Augusto

; Carneiro, Adriano Camargo de Castro

; Moreira, Valéria de Melo

; Trad, Henrique Simão

; Lopes, Marly Maria Uellendahl

; Cerci, Rodrigo Julio

; Nacif, Marcelo Souto

; Schvartzman, Paulo R.

; Chagas, Antônio Carlos Palandrini

; Costa, Isabela Bispo Santos da Silva

; Schmidt, André

; Shiozaki, Afonso Akio

; Montenegro, Sérgio Tavares

; Piegas, Leopoldo Soares

; Zapparoli, Marcelo

; Nicolau, José Carlos

; Fernandes, Fabio

; Hadlich, Marcelo Souza

; Ghorayeb, Nabil

; Mesquita, Evandro Tinoco

; Gonçalves, Luiz Flávio Galvão

; Ramires, Felix José Alvarez

; Fernandes, Juliano de Lara

; Schwartzmann, Pedro Vellosa

; Rassi, Salvador

; Torreão, Jorge Andion

; Mateos, José Carlos Pachón

; Beck-da-Silva, Luiz

; Silva, Marly Conceição

; Liberato, Gabriela

; Oliveira, Gláucia Maria Moraes de

; Feitosa Filho, Gilson Soares

; Carvalho, Hilka dos Santos Moraes de

; Markman Filho, Brivaldo

; Rocha, Ricardo Paulo de Sousa

; Azevedo Filho, Clerio Francisco de

; Taratsoutchi, Flávio

; Coelho-Filho, Otavio Rizzi

; Kalil Filho, Roberto

; Hajjar, Ludhmila Abrahão

; Ishikawa, Walther Yoshiharu

; Melo, Cíntia Acosta

; Jatene, Ieda Biscegli

; Albuquerque, Andrei Skromov de

; Rimkus, Carolina de Medeiros

; Silva, Paulo Savoia Dias da

; Vieira, Thiago Dieb Ristum

; Jatene, Fabio Biscegli

; Azevedo, Guilherme Sant Anna Antunes de

; Santos, Raul D.

; Monte, Guilherme Urpia

; Ramires, José Antonio Franchini

; Bittencourt, Marcio Sommer

; Avezum, Alvaro

; Silva, Leonardo Sara da

; Abizaid, Alexandre

; Gottlieb, Ilan

; Precoma, Dalton Bertolim

; Szarf, Gilberto

; Sousa, Antônio Carlos Sobral

; Pinto, Ibraim Masciarelli Francisco

; Medeiros, Fábio de Morais

; Caramelli, Bruno

; Parga Filho, José Rodrigues

; Santos, Tiago Senra Garcia dos

; Prazeres, Carlos Eduardo Elias dos

; Lopes, Marcelo Antonio Cartaxo Queiroga

; Avila, Luiz Francisco Rodrigues de

; Scanavacca, Mauricio Ibrahim

; Gowdak, Luis Henrique Wolff

; Barberato, Silvio Henrique

; Nomura, Cesar Higa

; Rochitte, Carlos Eduardo

Arquivos Brasileiros de Cardiologia

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2024, Volume 121 N. 9 elocation e20240608

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.36660/abc.20240608

Poetry Slam invade escolas de periferias paulistanas: eventos e práticas de letramentos literários no VIII Slam Interescolar de São Paulo paulistanas
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Neves, Cynthia Agra de Brito

; Santos, Sóstenes Renan de Jesus Carvalho

; Holanda, Maria Fabiana Medeiros de

Revista Brasileira de Linguística Aplicada

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2023, Volume 23 N. 3 elocation e42849

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Este artigo se propõe a descrever algumas cenas performadas por estudantes de escolas públicas paulistas, sobretudo das periferias, no VIII Slam Interescolar de São Paulo, visando discutir e analisar práticas de letramentos literários. Esse evento poético foi observado in loco pelos autores deste artigo, em específico, a performance poética da estudante do ensino fundamental II, Manoella de Souza, da Escola Estadual Dona Luiza Macuco. Os autores desta pesquisa assumem a perspectiva dos letramentos literários (Amorim; Domingues; Klayn; Silva, 2022; Neves, 2021a), dos letramentos de reexistência (Souza, 2011; Duboc; Menezes De Souza, 2021; Walsh, 2009, 2019) e dos letramentos críticos (Monte-Mór, 2015, 2019) em defesa do Poetry Slam como ato político-poético-performático de jovens da periferia paulistana. RESUMO paulistas periferias Paulo específico II Souza Macuco Amorim (Amorim Domingues Klayn Silva 2022 Neves 2021a, 2021a , 2021a) (Souza 2011 Duboc 2021 Walsh 2009 2019 MonteMór, MonteMór Monte Mór, Mór (Monte-Mór 2015 políticopoéticoperformático político performático paulistana 202 201 200 20 2

ABSTRACT: This paper aims to describe some scenes performed by students from São Paulo public schools, especially from the peripheries, at the VIII Inter-School Slams of São Paulo, to discuss and analyze literary literacies practices. This poetic event was observed on site by the authors of this paper, specifically the poetic performance of elementary school student Manoella de Souza, from the state school called Dona Luiza Macuco. The authors of this research take the perspective of literary literacies (Amorim; Domingues; Klayn; Silva, 2022; Neves, 2021a), literacies of reexistence (Souza, 2011; Duboc; Menezes De Souza, 2021; Walsh, 2009, 2019) and critical literacies (Monte-Mór, 2015, 2019) in defense of Poetry Slam as a political-poetic-performative act by young people from the outskirts of São Paulo. ABSTRACT schools peripheries InterSchool Inter School practices Souza Macuco Amorim (Amorim Domingues Klayn Silva 2022 Neves 2021a, 2021a , 2021a) (Souza 2011 Duboc 2021 Walsh 2009 2019 MonteMór, MonteMór Monte Mór, Mór (Monte-Mór 2015 politicalpoeticperformative political performative 202 201 200 20 2

https://doi.org/10.1590/1984-6398202342849

Effects of air temperature on the risk of death from COPD in major microregions in Brazil: a time series study Brazil
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Ribas, Igor Magaton

; Gomes, João Pedro Medeiros

; Valadares, Pedro Augusto Rosa

; Jardim, Lucas Santos

; Nogueira, Mário Círio

; Ferreira, Cássia de Castro Martins

; Farias, William Cossich Marcial de

; Ferreira, Letícia de Castro Martins

Jornal Brasileiro de Pneumologia

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2023, Volume 49 N. 5 elocation e20220442

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Avaliar a associação entre o risco de morte por DPOC e eventos de temperatura do ar em dez grandes microrregiões brasileiras. Métodos: Esta foi uma análise de série temporal de mortes diárias por DPOC e temperaturas médias diárias do ar entre 1996 e 2017. Utilizando modelos de defasagem não linear distribuídos, estimamos os riscos relativos cumulativos de mortalidade por DPOC para quatro percentis de temperatura (representando eventos moderados e extremos de frio e calor) em relação a uma temperatura mínima de mortalidade, com defasagem de 21 dias, em cada microrregião. Resultados: Foram encontradas associações significativas entre eventos extremos de temperatura do ar e o risco de morte por DPOC nas microrregiões Sul e Sudeste do Brasil. Houve associação de frio extremo e aumento do risco de mortalidade nas seguintes microrregiões: 36% (IC 95%, 1,12-1,65), em Porto Alegre; 27% (IC 95%, 1,03-1,58), em Curitiba; e 34% (IC 95%, 1,19-1,52), em São Paulo; enquanto o frio moderado foi associado a um risco aumentado de 20% (IC 95%, 1,01-1,41), 33% (IC 95%, 1,09-1,62) e 24% (IC 95%, 1,12-1,38) nas mesmas microrregiões, respectivamente. Houve aumento do risco de mortalidade por DPOC nas microrregiões de São Paulo e Rio de Janeiro: 17% (IC 95%, 1,05-1,31) e 12% (IC 95%, 1,02-1,23), respectivamente, devido ao calor moderado e 23% (IC 95%, 1,09-1,38) e 32% (IC 95%, 1,15-1,50) devido ao calor extremo. Conclusões: Eventos de temperatura do ar não ideal foram associados a um risco aumentado de morte por DPOC em áreas tropicais e subtropicais do Brasil. Objetivo brasileiras Métodos 199 2017 distribuídos representando 2 dias microrregião Resultados Brasil 36 IC 95 95% 1,121,65, 112165 1,12 1,65 , 1 12 65 1,12-1,65) Alegre 27 1,031,58, 103158 1,03 1,58 03 58 1,03-1,58) Curitiba 34 1,191,52, 119152 1,19 1,52 19 52 1,19-1,52) 20 1,011,41, 101141 1,01 1,41 01 41 1,01-1,41) 33 1,091,62 109162 1,09 1,62 09 62 1,09-1,62 24 1,121,38 112138 1,38 38 1,12-1,38 respectivamente Janeiro 17 1,051,31 105131 1,05 1,31 05 31 1,05-1,31 1,021,23, 102123 1,02 1,23 02 23 1,02-1,23) 1,091,38 109138 1,09-1,38 32 1,151,50 115150 1,15 1,50 15 50 1,15-1,50 Conclusões 201 3 9 121 1,121,65 11216 112 1,1 165 1,6 6 1,12-1,65 031 1,031,58 10315 103 1,0 158 1,5 0 5 1,03-1,58 191 1,191,52 11915 119 152 1,19-1,52 011 1,011,41 10114 101 141 1,4 4 1,01-1,41 091 1,091,6 10916 109 162 1,09-1,6 1,121,3 11213 138 1,3 1,12-1,3 051 1,051,3 10513 105 131 1,05-1,3 021 1,021,23 10212 102 123 1,2 1,02-1,23 1,091,3 10913 1,09-1,3 151 1,151,5 11515 115 150 1,15-1,5 1,121,6 1121 11 1, 16 1,12-1,6 1,031,5 1031 10 1,03-1,5 1,191,5 1191 1,19-1,5 1,011,4 1011 14 1,01-1,4 1,091, 1091 1,09-1, 1,121, 13 1,12-1, 1,051, 1051 1,05-1, 1,021,2 1021 1,02-1,2 1,151, 1151 1,15-1, 1,031, 1,03-1, 1,191, 1,19-1, 1,011, 1,01-1, 1,091 1,09-1 1,121 1,12-1 1,051 1,05-1 1,021, 1,02-1, 1,151 1,15-1 1,031 1,03-1 1,191 1,19-1 1,011 1,01-1 1,09- 1,12- 1,05- 1,021 1,02-1 1,15- 1,03- 1,19- 1,01- 1,02-

ABSTRACT Objective: To evaluate the association between the risk of death from COPD and air temperature events in ten major Brazilian microregions. Methods: This was a time series analysis of daily COPD deaths and daily mean air temperatures between 1996 and 2017. Using distributed nonlinear lag models, we estimated the cumulative relative risks of COPD mortality for four temperature percentiles (representing moderate and extreme cold and heat events) in relation to a minimum mortality temperature, with a lag of 21 days, in each microregion. Results: Significant associations were found between extreme air temperature events and the risk of death from COPD in the southern and southeastern microregions in Brazil. There was an association of extreme cold and an increased mortality risk in the following microregions: 36% (95% CI, 1.12-1.65), in Porto Alegre; 27% (95% CI, 1.03-1.58), in Curitiba; and 34% (95% CI, 1.19-1.52), in São Paulo; whereas moderate cold was associated with an increased risk of 20% (95% CI, 1.01-1.41), 33% (95% CI, 1.09-1.62), and 24% (95% CI, 1.12-1.38) in the same microregions, respectively. There was an increased COPD mortality risk in the São Paulo and Rio de Janeiro microregions: 17% (95% CI, 1.05-1.31) and 12% (95% CI, 1,02-1,23), respectively, due to moderate heat, and 23% (95% CI, 1,09-1,38) and 32% (95% CI, 1,15-1,50) due to extreme heat. Conclusions: Non-optimal air temperature events were associated with an increased risk of death from COPD in tropical and subtropical areas of Brazil. Objective Methods 199 2017 models representing 2 days microregion Results Brazil 36 95% 95 (95 CI 1.121.65, 112165 1.12 1.65 , 1 12 65 1.12-1.65) Alegre 27 1.031.58, 103158 1.03 1.58 03 58 1.03-1.58) Curitiba 34 1.191.52, 119152 1.19 1.52 19 52 1.19-1.52) 20 1.011.41, 101141 1.01 1.41 01 41 1.01-1.41) 33 1.091.62, 109162 1.09 1.62 09 62 1.09-1.62) 24 1.121.38 112138 1.38 38 1.12-1.38 respectively 17 1.051.31 105131 1.05 1.31 05 31 1.05-1.31 1,021,23, 102123 1,02 1,23 02 23 1,02-1,23) 1,091,38 109138 1,09 1,38 1,09-1,38 32 1,151,50 115150 1,15 1,50 15 50 1,15-1,50 Conclusions Nonoptimal Non optimal 201 3 9 (9 121 1.121.65 11216 112 1.1 165 1.6 6 1.12-1.65 031 1.031.58 10315 103 1.0 158 1.5 0 5 1.03-1.58 191 1.191.52 11915 119 152 1.19-1.52 011 1.011.41 10114 101 141 1.4 4 1.01-1.41 091 1.091.62 10916 109 162 1.09-1.62 1.121.3 11213 138 1.3 1.12-1.3 051 1.051.3 10513 105 131 1.05-1.3 021 1,021,23 10212 102 1,0 123 1,2 1,02-1,23 1,091,3 10913 1,3 1,09-1,3 151 1,151,5 11515 115 1,1 150 1,5 1,15-1,5 ( 1.121.6 1121 11 1. 16 1.12-1.6 1.031.5 1031 10 1.03-1.5 1.191.5 1191 1.19-1.5 1.011.4 1011 14 1.01-1.4 1.091.6 1091 1.09-1.6 1.121. 13 1.12-1. 1.051. 1051 1.05-1. 1,021,2 1021 1, 1,02-1,2 1,091, 1,09-1, 1,151, 1151 1,15-1, 1.031. 1.03-1. 1.191. 1.19-1. 1.011. 1.01-1. 1.091. 1.09-1. 1.121 1.12-1 1.051 1.05-1 1,021, 1,02-1, 1,091 1,09-1 1,151 1,15-1 1.031 1.03-1 1.191 1.19-1 1.011 1.01-1 1.091 1.09-1 1.12- 1.05- 1,021 1,02-1 1,09- 1,15- 1.03- 1.19- 1.01- 1.09- 1,02-

https://doi.org/10.36416/1806-3756/e20220442

Oral Mucositis in Children with Leukemia Undergoing Chemotherapy: A Case Series Chemotherapy
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Santos, Fabio Gomes dos

; Bezerra, Paula Maria Maracajá

; Limão, Nayara Pereira

; Santana, Ynnaiana Navarro de Lima

; Ribeiro, Isabella Lima Arrais

; Bonan, Paulo Rogério Ferreti

; Serpa, Eliane Batista de Medeiros

; Sousa, Simone Alves

; Valença, Ana Maria Gondim

Pesquisa Brasileira em Odontopediatria e Clínica Integrada

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2023, Volume 23 elocation e220140

Abstract: En | Text: En | PDF: En

ABSTRACT Objective: To report nine cases of pediatric patients with Acute Lymphoid Leukemia (ALL) or Acute Myeloid Leukemia who developed severe oral mucositis (SOM) at the first week of chemotherapy. Material and Methods: The cases were selected from a sample of 105 children followed for 10 consecutive weeks. Hematological and personal data were obtained from the patient's medical records. The oral cavity was examined weekly using the modified Oral Assessment Guide. Results: More of the patients were male (55.6%), had black/brown skin (55.6%), with ALL (66.7%), and the mean age was 5.55. Two patients had values below normal for leukocytes, platelets, and creatinine over the follow-up. However, all patients showed changes in the normality of hematological data in most weeks. The most used chemotherapeutic agents were aracytin, etoposide, and methotrexate, known for their high stomatotoxic potential. Patients had 2 to 6 (mean of 4) episodes of SOM and 4 to 7 (mean of 5.5) episodes of OM. One patient at week 7, one patient at week 5, and one patient at weeks 2 and 10 did not have OM. Saliva (84 times) and lips (44 times) were the most affected items. Conclusion: The patients showed oscillations in the severity of oral mucositis and hematological parameters over the follow-up. All patients were exposed to stomatotoxic drugs during the initial phase of cancer treatment. Objective (ALL (SOM chemotherapy Methods 1 s records Guide Results 55.6%, 556 55.6% , 55 (55.6%) blackbrown black brown 66.7%, 667 66.7% 66 (66.7%) 555 5 5.55 leukocytes platelets followup. followup follow up. up follow-up However aracytin etoposide methotrexate potential 5.5 OM 84 (8 times 44 (4 items Conclusion treatment 55.6 (55.6% 66.7 (66.7% 5. 8 ( 55. (55.6 66. (66.7 (55. (66. (55 (66 (5 (6

https://doi.org/10.1590/pboci.2023.067

AGREEMENT ON MRI DIAGNOSIS IN COMPRESSIVE MALIGNANT VERTEBRAL FRACTURES
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dos Santos, Iranilson Medeiros Germano

; Herrero, Carlos Fernando Pereira da Silva

; Pratali, Raphael de Rezende

; Agnollitto, Paulo Moraes

; Waib, Fernando Figueiredo

; Nogueira-Barbosa, Marcello Henrique

Acta Ortopédica Brasileira

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2023, Volume 31 N. spe1 elocation e258926

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Verificar a concordância interobservador e intraobservador no diagnóstico de fraturas vertebrais compressivas malignas (MCVF) por meio de ressonância magnética (MRI). Métodos: Incluiu-se retrospectivamente a ressonância magnética da coluna lombar de 63 pacientes com diagnóstico de fratura vertebral compressiva não traumática. Cada vértebra lombar foi classificada da seguinte forma: sem fratura, com fratura de características benignas ou com fratura de características malignas. Dois médicos residentes em radiologia, um pesquisador radiologista musculoesquelético, um radiologista musculoesquelético e dois cirurgiões da coluna vertebral avaliaram os exames de ressonância magnética, independentemente e cegamente. Cada observador realizou duas leituras, com um intervalo de 15 dias entre as avaliações. O coeficiente Kappa simples foi utilizado para calcular o acordo intra e interobservador. A classificação padrão de referência foi baseada em biópsia óssea ou clínica, e acompanhamento por imagem de pelo menos dois anos, para análise de desempenho diagnóstico. O desempenho diagnóstico foi avaliado através do cálculo de sensibilidade, especificidade, precisão, valores preditivos positivos e negativos com um intervalo de confiança de 95% (IC). Resultados: Foi observada concordância substancial a perfeita intraobservador (kappa: 0,80 a 1,00) e concordância substancial interobservador (kappa 0,64 a 0,77). Em geral, a sensibilidade para a detecção de MCVF foi moderada, exceto para o segundo ano de residência radiológica que alcançou uma sensibilidade menor. A especificidade, precisão e valor preditivo negativo foram altos para todos os observadores. Conclusão: O diagnóstico de MCVF por ressonância magnética mostrou uma concordância substancial entre observadores. O residente médico do segundo ano alcançou uma sensibilidade menor, mas alta especificidade para MCVF. Com relação aos veteranos, não houve significância estatística entre os cirurgiões da coluna vertebral e o radiologista músculo-esquelético. Nível de Evidencia III; Diagnóstico. Objetivo (MCVF MRI. MRI . (MRI) Métodos Incluiuse Incluiu se 6 traumática forma radiologia cegamente leituras 1 avaliações clínica anos 95 IC. IC (IC) Resultados kappa 080 0 80 0,8 1,00 100 00 064 64 0,6 0,77. 077 0,77 77 0,77) geral moderada menor observadores Conclusão veteranos músculoesquelético. músculoesquelético músculo esquelético. esquelético músculo-esquelético III Diagnóstico (MRI 9 (IC 08 8 0, 1,0 10 06 07 0,7 7 1,

ABSTRACT Objective: Verify interobserver and intraobserver agreement of malignant compressive vertebral fractures (MCVF) diagnosis using magnetic resonance imaging (MRI). Methods: We retrospectively included a lumbar spine MRI of 63 patients with non-traumatic compressive vertebral fracture diagnoses. Each lumbar vertebra was classified as: without fracture, with fracture of benign characteristics, or with fracture of malignant characteristics. Two medical residents in radiology, one musculoskeletal radiologist fellow, one musculoskeletal radiologist, and two spine surgeons evaluated MRI exams, independently and blindly. Each observer performed two readings, with a 15-day interval between evaluations. A simple Kappa coefficient was used to calculate the intra and interobserver agreement. The reference standard classification was based on bone biopsy or clinical, and imaging follow-up of at least two years, for diagnostic performance analysis. Diagnostic performance was assessed by calculating sensitivity, specificity, accuracy, and positive and negative predictive values with a 95% confidence interval (CI). Results: We observed substantial to perfect intraobserver agreement (kappa: 0.80 to 1.00) and substantial interobserver agreement (kappa 0.64 to 0.77). In general, the sensitivity for the detection of MCVF was moderate, except for the second-year radiology resident that achieved a lower sensitivity. The specificity, accuracy, and negative predictive value were high for all observers. Conclusion: MCVF diagnosis using MRI showed substantial interobserver agreement. The second-year medical resident achieved lower sensitivity but high specificity for MCVF. Regarding the seniors, there was no statistical significance between spine surgeons and the musculoskeletal radiologist. Level of Evidence III; Diagnostic. Objective (MCVF MRI. . (MRI) Methods 6 nontraumatic non traumatic diagnoses as characteristics fellow exams blindly readings 15day day 15 evaluations clinical followup follow up years analysis accuracy 95 CI. CI (CI) Results kappa 080 0 80 0.8 1.00 100 1 00 064 64 0.6 0.77. 077 0.77 77 0.77) general moderate secondyear second year observers Conclusion seniors III (MRI 9 (CI 08 8 0. 1.0 10 06 07 0.7 7 1.

https://doi.org/10.1590/1413-785220233101e258926

10.

An alternative route to extract nickel and cobalt from non-commercial laterite ore
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Ribeiro, Pedro Paulo Medeiros

; Neumann, Reiner

; Santos, Iranildes Daniel dos

; Dutra, Achilles Junqueira Bourdot

REM - International Engineering Journal

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sep 2022, Volume 75 N. 3 Pages 245 - 257

Abstract: En | Text: En | PDF: En

Abstract Laterite ores, which represent around two-thirds of nickel reserves, became an important source of nickel and cobalt metals. The objective of the present study was to investigate the efficiency of a hybrid route to extract nickel and cobalt present in a laterite ore sample which was not commercially attractive to be processed through the current routes. The process efficiency was investigated through the application of different test conditions, such as roast temperature, ore sample comminution, and moisture. Chemical analysis by atomic absorption was used to quantify the metals. The solid phase’s identification and characterization were accomplished by X-ray diffraction and Scanning Electron Microscopy. The Rietveld Method was used for the mineral’s phase quantification. In terms of nickel and cobalt extractions, the most favorable condition was: particle size smaller than 38 µm, 50% sulfuric acid (wt.%), and 10% moisture (wt.%), which permitted nickel, cobalt, magnesium, and iron recoveries of 84.5%, 92.0%, and 93.0%, 27.0% respectively. These results indicate the successful application of the route. In addition, it was found that chlorite, chromite, hematite, and goethite were identified as the main nickel and cobalt carriers present in the process residue.

https://doi.org/10.1590/0370-44672021750048

11.

Use of Chlorhexidine Bioadhesive Gel to Reduce Infection and Discomfort in Alveolar Bone Graft Wound: A Randomized Pilot Study
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da Fonseca Orcina, Bernardo

; Medeiros Battistetti, Marcelo

; de Almeida Barbosa Mello, Marina

; Faria Yaedú, Renato Yassutaka

; da-Silva-Santos, Paulo Sérgio

International journal of odontostomatology

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sep 2022, Volume 16 N. 3 Pages 359 - 363

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT: The objective of this study was to analyze the inflammation index, edema, bacterial plaque presence and postoperative discomfort, with the use of chlorhexidine gel. This is a randomized double-blinded pilot study, with 21 unilateral cleft lip and palate individuals, randomized into 2 groups: Test Group (TG), with 7 individuals who used 0.2 % chlorhexidine bioadhesive gel in the surgical wound after the bone graft; and Control Group (CG) with 14 individuals who used a placebo gel as the same way. The gel was applied on the surgical wound suture after alveolar bone graft. The evaluation criteria of the gel application effectiveness were the visual analogue scale (VAS) for pain control and/or discomfor t and clinical evaluation of inflammatory condition and/or wound infection. The study showed promising results for postoperativel y use of the chlorhexidine gel, although there was no statistically significant difference between the groups.

RESUMEN: El objetivo de este estudio fue analizar el índice de inflamación, edema, presencia de placa bacteriana y molestias postoperatorias, con el uso del gel de clorhexidina. Se trata de un estudio piloto aleatorizado, doble ciego, con 21 individuos con fisura labial y palatina unilateral, aleatorizados en 2 grupos: Grupo Test (GT), con 7 individuos que utilizaron gel bioadhesivo de clorhexidina al 0,2 % en la herida quirúrgica posterior al injerto óseo; y Grupo Control (GC) con 14 individuos que usaron un gel placebo de la misma forma. El gel se aplicó sobre la sutura de la herida quirúrgica después del injerto óseo alveolar. Los criterios de evaluación de la efectividad de la aplicación del gel fueron la escala analógica visual (EVA) para el control del dolor y/o malestar y la evaluación clínica del estado inflamatorio y/o infección de la herida. El estudio mostró resultados positivos para el uso posoperatorio del gel de clorhexidina, aunque no hubo diferencias estadísticamente significativas entre los grupos.

12.

Adaptação transcultural e validação para o Português (Brasil) do Parent Attitudes About Childhood Vaccine (PACV)
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Santos Júnior, Claudio José dos

; Costa, Paulo José Medeiros de Souza

Ciência & Saúde Coletiva

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may 2022, Volume 27 N. 5 Pages 2057 - 2070

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo No Brasil, a despeito da hesitação vacinal ser um problema reconhecido, sua mensuração ainda é um desafio. Por outro lado, sabe-se que identificar pais com hesitação às vacinas é condição fundamental para a implementação de programas eficientes de educação em saúde. Assim, o objetivo deste trabalho foi realizar a adaptação transcultural e a validação do Parent Attitudes About Childhood Vaccine (PACV) para o português brasileiro. Trata-se, portanto, de um estudo de adaptação transcultural que envolveu as seguintes etapas: tradução, síntese, retrotradução, avaliação da qualidade, comitê de especialistas, pré-teste, avaliação da confiabilidade e, por fim, submissão e aprovação. Após a realização dessas etapas, foi observado que, na avaliação do Índice de Validade de Conteúdo (IVC), nenhuma questão do PACV obteve IVC<0,80 nas dimensões de equivalência semântica, idiomática, conceitual e cultural. No IVC global, a versão brasileira do PACV alcançou 0,91, indicando boa concordância interavaliador e evidência de validade baseada no conteúdo. O alfa de Cronbach para o instrumento foi de 0,91. O PACV foi adaptado para o Português do Brasil, dando origem ao PAVC-Brasil, versão que apresentou evidências de validade baseada no conteúdo, além de boa consistência interna.

Abstract Despite vaccine hesitancy being a recognized problem in Brazil, the extent of the problem is still a challenge. However, it is acknowledged that identifying parents who are hesitant about vaccines is a fundamental condition for the implementation of efficient health communication programs. Thus, the scope of this work was to carry out the cross-cultural adaptation and validation of the Parent Attitudes About Childhood Vaccine (PACV) questionnaire in Brazilian Portuguese. It is a cross-cultural adaptation study with the following steps: translation, synthesis, back-translation, quality assessment, expert committee, pre-test, reliability assessment and, finally, submission and approval. After carrying out these steps, it was observed that, in the evaluation of the Content Validity Index (CVI), no PACV question obtained CVI<0.80 in the dimensions of semantic, idiomatic, conceptual and cultural equivalence. In the global IVC, the Brazilian version of the PACV reached 0.91, indicating good interappraiser agreement and evidence of content-based validity. Cronbach’s alpha for the instrument was 0.91. The PACV was adapted to Brazilian Portuguese, giving rise to the PAVC-Brasil version, which presented evidence of content-based validity, in addition to good internal consistency.

https://doi.org/10.1590/1413-81232022275.11802021

13.

Adaptação transcultural e validação para o Português (Brasil) do Parent Attitudes About Childhood Vaccine (PACV)
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Santos Júnior, Claudio José dos

; Costa, Paulo José Medeiros de Souza

Ciência & Saúde Coletiva

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may 2022, Volume 27 N. 5 Pages 2057 - 2070

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232022275.11802021

14.

Brazilian initial experience with lung transplantation due to irreversible lung fibrosis post-COVID-19 in a national reference center: a cohort study
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Reis, Flavio Pola dos

; Fernandes, Lucas Matos

; Abdalla, Luis Gustavo

; Campos, Silvia Vidal

; Camargo, Priscila Cilene Leon Bueno de

; Santos, Samuel Lucas dos

; Aguiar, Ivana Teixeira de

; Pires, Juliana Patricia

; Costa, Andre Nathan

; Carraro, Rafael Medeiros

; Teixeira, Ricardo Henrique de Oliveira Braga

; Pêgo-Fernandes, Paulo Manuel

Sao Paulo Medical Journal

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feb 2022, Volume 140 N. 1 Pages 153 - 159

Abstract: En | Text: En | PDF: En

ABSTRACT BACKGROUND: Lung transplantation (LTx) has been discussed as an option for treating irreversible lung fibrosis post-coronavirus disease 2019 (COVID-19), in selected cases. OBJECTIVES: To report on the initial experience and management of end-stage lung disease due to COVID-19 at a national center reference in Brazil. DESIGN AND SETTING: Cohort study conducted at a national reference center for lung transplantation. METHODS: Medical charts were reviewed regarding patients’ demographics and pre-COVID-19 characteristics, post-LTx due to COVID-19. RESULTS: Between March 2020 and September 2021, there were 33 cases of LTx. During this period, we evaluated 11 cases of severe COVID-19-related acute respiratory distress syndrome (ARDS) that were potentially candidates for LTx. Among these, LTx was only indicated for three patients (9.1%). All of these patients were on venovenous extracorporeal membrane oxygenation (ECMO), and the procedure that they underwent was central venoarterial ECMO. All three patients were still alive after the first 30 postoperative days. However, patient #1 and patient #2 subsequently died due to fungal sepsis on the 47th and 52nd postoperative days, respectively. Patient #3 was discharged on the 30th postoperative day. CONCLUSIONS: LTx is feasible among these complex patients. Survival over the first 30 days was 100%, and this favors surgical feasibility. Nonetheless, these were critically ill patients.

https://doi.org/10.1590/1516-3180.2021.0842.r1.13102021

15.

SURGICAL MANAGEMENT OF ADULT CROHN’S DISEASE AND ULCERATIVE COLITIS PATIENTS: A CONSENSUS FROM THE BRAZILIAN ORGANIZATION OF CROHN’S DISEASE AND COLITIS (GEDIIB) CROHNS CROHN S PATIENTS GEDIIB (GEDIIB
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ZABOT, Gilmara Pandolfo

; CASSOL, Ornella Sari

; QUARESMA, Abel Botelho

; GONÇALVES FILHO, Francisco de Assis

; BAIMA, Júlio Pinheiro

; IMBRIZI, Marcello

; ROLIM, Alexandre de Sá

; CARMO, Alexandre Medeiros do

; ALVES JUNIOR, Antonio Jose Tiburcio

; SANTOS, Carlos Henrique Marques dos

; SOBRADO JUNIOR, Carlos Walter

; MIRANDA, Eron Fábio

; ALBUQUERQUE, Idblan Carvalho de

; SOUZA, Mardem Machado de

; KAISER JUNIOR, Roberto Luiz

; PARRA, Rogerio Serafim

; KOTZE, Paulo Gustavo

; SAAD-HOSSNE, Rogério

Arquivos de Gastroenterologia

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2022, Volume 59 Suppl. 1 Pages 1 - 19

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Contexto: Apesar da terapia medicamentosa otimizada, o risco contemporâneo de cirurgia nas doenças inflamatórias intestinais (DII) após 10 anos do diagnóstico é de 9,2% em pacientes com retocolite ulcerativa (RCU) e de 26,2% na doença de Crohn (DC) na era biológica. Objetivo: Este consenso visa detalhar as orientações para os procedimentos cirúrgicos mais adequados em diferentes cenários da DII. Além disso, detalha as indicações cirúrgicas e o manejo perioperatório de pacientes adultos com DC e RCU. Métodos: Nosso consenso foi desenvolvido por cirurgiões colorretais e gastroenterologistas representantes da Organização Brasileira de Doença de Crohn e Colite (GEDIIB), com a metodologia de revisão rápida sendo conduzida para respaldar as recomendações. As recomendações cirúrgicas foram estruturadas e mapeadas de acordo com os fenótipos da doença, indicações cirúrgicas e técnicas. Após a estruturação das recomendações, a metodologia modificada do Painel Delphi foi utilizada para conduzir a votação por especialistas em cirurgia de DII e gastroenterologia. Esta consistiu em três rondas: duas com recurso a uma plataforma de votação online personalizada e anônima e uma reunião presencial. Sempre que os participantes não concordavam com afirmações ou recomendações específicas, era oferecida uma opção de delinear possíveis razões para permitir respostas em texto livre e dar a oportunidade para os especialistas elaborarem ou explicarem a discordância. O consenso de recomendações/declarações em cada rodada foi considerado alcançado se houve concordância ≥80%. Resultados e conclusão Este consenso abordou as informações mais relevantes para orientar o processo de tomada de decisão para o manejo cirúrgico adequado de DC e RCU. Ele sintetiza recomendações desenvolvidas a partir de evidências e conhecimento de alto nível. As recomendações cirúrgicas foram estruturadas e mapeadas de acordo com os diferentes fenótipos da doença, indicações para cirurgia e manejo perioperatório. O foco específico do nosso consenso foi dado aos procedimentos cirúrgicos eletivos e de emergência, determinando quando indicar a cirurgia e quais procedimentos podem ser os mais adequados. O consenso é direcionado a gastroenterologistas e cirurgiões interessados no tratamento e manejo de pacientes adultos com DC ou RCU e apoia a tomada de decisões de pagadores de saúde, líderes institucionais e/ou administradores. Contexto otimizada (DII 1 92 9 2 9,2 (RCU 262 26 26,2 (DC biológica Objetivo disso Métodos GEDIIB, GEDIIB , (GEDIIB) técnicas gastroenterologia rondas presencial específicas discordância recomendaçõesdeclarações declarações 80 ≥80% nível emergência saúde eou administradores 9, 26, (GEDIIB 8 ≥80 ≥8 ≥

ABSTRACT Background: Despite optimized medical therapy, contemporary risk of surgery in inflammatory bowel diseases (IBD) after 10 years of diagnosis is 9.2% in patients with ulcerative colitis (UC) and 26.2% in Crohn’s disease, (CD) in the biological era. Objective: This consensus aims to detail guidance to the most appropriate surgical procedures in different IBD scenarios. In addition, it details surgical indications and perioperative management of adult patients with CD and UC. Methods: Our consensus was developed by colorectal surgeons and gastroenterologists representing the Brazilian Study Group of Inflammatory Bowel Diseases (GEDIIB), with the Rapid Review methodology being conducted to support the recommendations/statements. Surgical recommendations were structured and mapped according to the disease phenotypes, surgical indications, and techniques. After structuring the recommendations/statements, the modified Delphi Panel methodology was used to conduct the voting by experts in IBD surgery and gastroenterology. This consisted of three rounds: two using a personalized and anonymous online voting platform and one face-to-face presential meeting. Whenever participants did not agree with specific statements or recommendations, an option to outline possible reasons was offered to enable free-text responses and provide the opportunity for the experts to elaborate or explain disagreement. The consensus of recommendations/statements in each round was considered to have been reached if there was ≥80% agreement. Results and conclusion: This consensus addressed the most relevant information to guide the decision-making process for adequate surgical management of CD and UC. It synthesizes recommendations developed from evidence-based statements and state-of-art knowledge. Surgical recommendations were structured and mapped according to the different disease phenotypes, indications for surgery and perioperative management. Specific focus of our consensus was given to elective and emergency surgical procedures, determining when to indicate surgery and which procedures may be the more appropriate. The consensus is targeted to gastroenterologists and surgeons interested in the treatment and management of adult patients with CD or UC and supports decision-making of healthcare payors, institutional leaders, and/or administrators. Background therapy (IBD 1 92 9 2 9.2 (UC 262 26 26.2 Crohns Crohn s (CD era Objective scenarios addition Methods GEDIIB, GEDIIB , (GEDIIB) recommendationsstatements phenotypes techniques gastroenterology rounds facetoface face meeting freetext free text disagreement 80 ≥80 agreement conclusion decisionmaking decision making evidencebased evidence based stateofart state art knowledge payors leaders andor administrators 9. 26. (GEDIIB 8 ≥8 ≥

https://doi.org/10.1590/s0004-2803.2022005s1-01

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