Resumen Objetivo: Comparar uso y registro del carné de control pediátrico (CCP) entre madres beneficiarias y no beneficiarias del Programa Bolsa Familia (PBF). Métodos: Estudio transversal entre enero y febrero del 2023 con madres de niños < 6años, en unidades de salud de Salvador-Bahía. Se evaluó CSN en términos de uso (tener el carné, tenerlo en mano y haberlo leído) y registro (curvas de crecimiento, formularios del desarrollo y vacunación). Se utilizó estadística descriptiva y prueba de chi-cuadrado. Resultados: De los 411 participantes, el 66% fueron del PBF. Hubo diferencia significativa entre los grupos respecto al uso del CCP: tenerlo (p < 0,001), concurrir con él (p = 0,037) haberlo leído (p < 0,001). Respecto al registro, hubo diferencia significativa sólo en vacunación (p = 0,005). Conclusión: Hubo diferencia significativa en el uso y cumplimiento de la vacunación, comparando madres beneficiarias y no beneficiarias del PBF.

Resumo Objetivo: Comparar uso e preenchimento da caderneta da criança entre mães beneficiárias ou não do Programa Bolsa Família. Métodos: Estudo transversal com mães de crianças menores de 6 anos em unidades de saúde de Salvador-BA, entre janeiro e fevereiro de 2023. A caderneta da criança foi avaliada quanto ao uso (ter a caderneta, estar com ela em mãos e tê-la lido) e preenchimento (curvas de crescimento, fichas de avaliação do desenvolvimento e completude vacinal). Utilizaram-se estatística descritiva e teste qui-quadrado, com nível de significância de 5%. Resultados: Das 411 participantes do estudo, 66% eram beneficiárias do programa. Houve diferença significativa entre os grupos quanto ao uso da caderneta: ter a caderneta (p < 0,001), estar com ela em mãos (p = 0,037) e tê-la lido (p < 0,001). Quanto ao preenchimento, houve diferença significativa apenas na completude vacinal (p = 0,005). Conclusão: Houve diferença significativa quanto ao uso e à completude vacinal, comparando-se mães beneficiárias e não beneficiárias do Programa Bolsa Família.

Abstract Objective: To compare child health booklet (CHB) use and filling out among mothers who were or were not Bolsa Família Program (BFP) beneficiaries. Methods: Cross-sectional study with mothers of children <6years attending health centers in Salvador, Bahia, Brazil, between January-February/2023. The CHB was evaluated regarding its use (having a CHB, having it in hand, and having read it) and filling out (growth curves, development monitoring forms, and vaccination completeness). Descriptive statistics and the chi-square test were used. Results: Of the 411 study participants, 66% were BFP beneficiaries. Significant differences were found between the groups regarding CHB use: having a CHB (p < 0.001), having it in hand (p = 0.037), and having read it (p < 0.001). Significant difference in vaccination completeness was found (p = 0.005). Conclusion: There was a significant difference in CHB use and vaccination completeness when comparing mothers who were BFP beneficiaries and those who were not.

Resumo Objetivo: Comparar uso e preenchimento da caderneta da criança entre mães beneficiárias ou não do Programa Bolsa Família. Métodos: Estudo transversal com mães de crianças menores de 6 anos em unidades de saúde de Salvador-BA, entre janeiro e fevereiro de 2023. A caderneta da criança foi avaliada quanto ao uso (ter a caderneta, estar com ela em mãos e tê-la lido) e preenchimento (curvas de crescimento, fichas de avaliação do desenvolvimento e completude vacinal). Utilizaram-se estatística descritiva e teste qui-quadrado, com nível de significância de 5%. Resultados: Das 411 participantes do estudo, 66% eram beneficiárias do programa. Houve diferença significativa entre os grupos quanto ao uso da caderneta: ter a caderneta (p < 0,001), estar com ela em mãos (p = 0,037) e tê-la lido (p < 0,001). Quanto ao preenchimento, houve diferença significativa apenas na completude vacinal (p = 0,005). Conclusão: Houve diferença significativa quanto ao uso e à completude vacinal, comparando-se mães beneficiárias e não beneficiárias do Programa Bolsa Família. Objetivo Família Métodos SalvadorBA, SalvadorBA Salvador BA, BA Salvador-BA 2023 têla tê la curvas crescimento vacinal. . vacinal) Utilizaramse Utilizaram se quiquadrado, quiquadrado qui quadrado, quadrado qui-quadrado 5 5% Resultados 41 estudo 66 programa p 0,001, 0001 0,001 , 0 001 0,001) 0,037 0037 037 0,001. 0,005. 0005 0,005 005 0,005) Conclusão comparandose comparando 202 4 000 0,00 00 0,03 003 03 20 0,0 2 0,

Abstract Objective: To compare child health booklet (CHB) use and filling out among mothers who were or were not Bolsa Família Program (BFP) beneficiaries. Methods: Cross-sectional study with mothers of children <6years attending health centers in Salvador, Bahia, Brazil, between January-February/2023. The CHB was evaluated regarding its use (having a CHB, having it in hand, and having read it) and filling out (growth curves, development monitoring forms, and vaccination completeness). Descriptive statistics and the chi-square test were used. Results: Of the 411 study participants, 66% were BFP beneficiaries. Significant differences were found between the groups regarding CHB use: having a CHB (p < 0.001), having it in hand (p = 0.037), and having read it (p < 0.001). Significant difference in vaccination completeness was found (p = 0.005). Conclusion: There was a significant difference in CHB use and vaccination completeness when comparing mothers who were BFP beneficiaries and those who were not. Objective (CHB (BFP Methods Crosssectional Cross sectional 6years years Salvador Bahia Brazil JanuaryFebruary/2023. JanuaryFebruary2023 JanuaryFebruary January February/2023. February 2023 January-February/2023 growth curves forms completeness. . completeness) chisquare chi square used Results 41 participants 66 p 0.001, 0001 0.001 , 0 001 0.001) 0.037, 0037 0.037 037 0.037) 0.001. 0.005. 0005 0.005 005 0.005) Conclusion JanuaryFebruary/2023 JanuaryFebruary202 February2023 February/2023 202 January-February/202 4 6 000 0.00 00 003 0.03 03 JanuaryFebruary/202 JanuaryFebruary20 February202 February/202 20 January-February/20 0.0 JanuaryFebruary/20 JanuaryFebruary2 February20 February/20 2 January-February/2 0. JanuaryFebruary/2 February2 February/2 January-February/ JanuaryFebruary/ February/ January-February

Resumen Objetivo: Comparar uso y registro del carné de control pediátrico (CCP) entre madres beneficiarias y no beneficiarias del Programa Bolsa Familia (PBF). Métodos: Estudio transversal entre enero y febrero del 2023 con madres de niños < 6años, en unidades de salud de Salvador-Bahía. Se evaluó CSN en términos de uso (tener el carné, tenerlo en mano y haberlo leído) y registro (curvas de crecimiento, formularios del desarrollo y vacunación). Se utilizó estadística descriptiva y prueba de chi-cuadrado. Resultados: De los 411 participantes, el 66% fueron del PBF. Hubo diferencia significativa entre los grupos respecto al uso del CCP: tenerlo (p < 0,001), concurrir con él (p = 0,037) haberlo leído (p < 0,001). Respecto al registro, hubo diferencia significativa sólo en vacunación (p = 0,005). Conclusión: Hubo diferencia significativa en el uso y cumplimiento de la vacunación, comparando madres beneficiarias y no beneficiarias del PBF. Objetivo CCP (CCP PBF . (PBF) Métodos 202 6años años SalvadorBahía. SalvadorBahía Salvador Bahía. Bahía Salvador-Bahía tener curvas crecimiento vacunación. vacunación) chicuadrado. chicuadrado chi cuadrado. cuadrado chi-cuadrado Resultados 41 participantes 66 p 0,001, 0001 0,001 , 0 001 0,001) 0,037 0037 037 0,001. 0,005. 0005 0,005 005 0,005) Conclusión (PBF 20 4 6 000 0,00 00 0,03 003 03 2 0,0 0,

ABSTRACT Agrosilvopastoral systems have been used as sustainable production models that can promote soil organic carbon (SOC) storage. However, there are no simulation studies with the Century model to estimate the SOC accumulation capacity in the long term, analyzing the effects of management and climate change in integrated crop-livestock-forest (ICLF) systems. This study aimed to simulate soil C dynamics in two chronosequences of land-use composed of native vegetation (NV), degraded pasture (DPA) and ICLF system in the Cerrado of Minas Gerais, in addition to designing future scenarios to verify the potential of SOC accumulation through climate change. The results showed that the Century model reliably simulated the SOC stocks in the two chronosequences evaluated. The model predicted an increase in SOC stocks at two sites by converting the DPA system (46.04 and 42.38 Mg ha-1) into ICLF systems (54.94 and 51.71 Mg ha-1). The Century also predicted that a 20 mm decrease in rainfall and a 2 °C increase in temperature in the tropical regions studied could reduce the SOC stocks more expressively in degraded pastures, while agroforestry systems could show a smaller reduction in SOC stocks. In addition, the results showed that replacing degraded pastures into agrosilvopastoral systems, especially in clayey soils, contributes to increasing SOC stocks. Thus, agroforestry systems are potentially viable to maintain the sustainability of agriculture in the face of climate change. (SOC storage However term croplivestockforest crop livestock forest (ICLF landuse land use NV, NV , (NV) (DPA Gerais evaluated 46.04 4604 46 04 (46.0 4238 42 38 42.3 ha1 ha 1 ha-1 54.94 5494 54 94 (54.9 5171 51 71 51.7 ha1. . soils Thus (NV 46.0 460 4 0 (46. 423 3 42. ha- 54.9 549 5 9 (54. 517 7 51. 46. (46 54. (54 (4 (5 (

ABSTRACT This cross-sectional study aimed to identify adjustments regarding the use of Personal Protective Equipment and the organization of the work process in outpatient dental care in Paraná during the first year of the COVID-19 pandemic. The convenience sample included 1,105 oral health professionals (dental surgeons, oral health assistants, and dental hygienists) during the first year of the pandemic (August to October, 2020). An online form (Google Forms®) was sent by email by the Regional Council of Dentistry. COVID-19’s measures were compared between the types of dental services: ‘outpatient clinic of the Unified Health System – SUS’ (Primary Care, Dental Specialty Center, and Emergency Care), ‘private clinic’ and ‘other services’ (Sistema S, security forces, trade union, public and private hospitals, and teaching clinics). Professionals from SUS outpatient services reported more frequently: that they suspended elective care, avoided generating aerosols, and worked four-handed. Professionals from ‘private clinics’ used teleorientation and telemonitoring more regularly. In the ‘other services’, there was a more significant proportion reduction in work hours and handpieces autoclaving after each service. It is concluded that, despite the high adequacy of the measures to combat COVID-19, there was a difference in professional practice among the different types of dental services.

RESUMO O objetivo deste estudo transversal foi identificar adequações quanto à utilização de Equipamentos de Proteção Individual e organização do processo de trabalho no atendimento odontológico ambulatorial no Paraná durante o primeiro ano da pandemia da Covid-19. A amostra de conveniência incluiu 1.105 profissionais de saúde bucal (cirurgiões-dentistas, técnicos e auxiliares em saúde bucal) durante o primeiro ano da pandemia (agosto a outubro de 2020). Formulário on-line (Google Formulários®) foi enviado por e-mail pelo Conselho Regional de Odontologia. As medidas de enfrentamento da Covid-19 foram comparadas entre os tipos de serviços odontológicos: ambulatorial do Sistema Único de Saúde – SUS (Atenção Primária, Centro de Especialidades Odontológicos e Pronto Atendimento), clínica privada, e outros (Sistema S, forças de segurança, sindicatos, hospitais públicos e privados e clínicas de ensino). Os profissionais dos serviços ambulatoriais do SUS relataram com maior frequência que: suspenderam atendimentos eletivos, evitavam gerar aerossóis e trabalhavam a quatro mãos. Nas clínicas privadas, utilizavam frequentemente teleorientação e telemonitoramento. Nos ‘outros serviços’, houve maior proporção de redução das horas de trabalho e autoclavagem de peças de mão após cada atendimento. Conclui-se que, apesar da alta adequação às medidas de enfrentamento da Covid-19, houve diferença na prática profissional nos diferentes tipos de serviços odontológicos.

RESUMO O objetivo deste estudo transversal foi identificar adequações quanto à utilização de Equipamentos de Proteção Individual e organização do processo de trabalho no atendimento odontológico ambulatorial no Paraná durante o primeiro ano da pandemia da Covid-19. A amostra de conveniência incluiu 1.105 profissionais de saúde bucal (cirurgiões-dentistas, técnicos e auxiliares em saúde bucal) durante o primeiro ano da pandemia (agosto a outubro de 2020). Formulário on-line (Google Formulários®) foi enviado por e-mail pelo Conselho Regional de Odontologia. As medidas de enfrentamento da Covid-19 foram comparadas entre os tipos de serviços odontológicos: ambulatorial do Sistema Único de Saúde – SUS (Atenção Primária, Centro de Especialidades Odontológicos e Pronto Atendimento), clínica privada, e outros (Sistema S, forças de segurança, sindicatos, hospitais públicos e privados e clínicas de ensino). Os profissionais dos serviços ambulatoriais do SUS relataram com maior frequência que: suspenderam atendimentos eletivos, evitavam gerar aerossóis e trabalhavam a quatro mãos. Nas clínicas privadas, utilizavam frequentemente teleorientação e telemonitoramento. Nos ‘outros serviços’, houve maior proporção de redução das horas de trabalho e autoclavagem de peças de mão após cada atendimento. Conclui-se que, apesar da alta adequação às medidas de enfrentamento da Covid-19, houve diferença na prática profissional nos diferentes tipos de serviços odontológicos.

ABSTRACT This cross-sectional study aimed to identify adjustments regarding the use of Personal Protective Equipment and the organization of the work process in outpatient dental care in Paraná during the first year of the COVID-19 pandemic. The convenience sample included 1,105 oral health professionals (dental surgeons, oral health assistants, and dental hygienists) during the first year of the pandemic (August to October, 2020). An online form (Google Forms®) was sent by email by the Regional Council of Dentistry. COVID-19’s measures were compared between the types of dental services: ‘outpatient clinic of the Unified Health System – SUS’ (Primary Care, Dental Specialty Center, and Emergency Care), ‘private clinic’ and ‘other services’ (Sistema S, security forces, trade union, public and private hospitals, and teaching clinics). Professionals from SUS outpatient services reported more frequently: that they suspended elective care, avoided generating aerosols, and worked four-handed. Professionals from ‘private clinics’ used teleorientation and telemonitoring more regularly. In the ‘other services’, there was a more significant proportion reduction in work hours and handpieces autoclaving after each service. It is concluded that, despite the high adequacy of the measures to combat COVID-19, there was a difference in professional practice among the different types of dental services.

Resumo Objetivo: analisar o conceito de “violência obstétrica” no contexto da enfermagem, a partir da identificação de seus antecedentes, atributos e consequentes. Materiais e método: trata-se de uma análise conceitual, a qual segue o método proposto pelo modelo de Walker e Avant, que consiste em oito etapas. Para contemplar o objetivo do estudo, foram utilizadas seis etapas: seleção do conceito; delimitação dos objetivos da análise; identificação dos usos do conceito na literatura; determinação dos atributos essenciais; identificação dos antecedentes e consequentes do conceito, e definição das referências empíricas do conceito. Resultados: a amostra foi composta de 22 estudos. Foram evidenciados 31 antecedentes: 24 atributos para a violência física; 35, para a psicológica/emocional; 6, para a institucional; 6, para a violência sexual e 5, para a violência estrutural. No tocante aos consequentes, foram encontrados 39 elementos. Conclusões: o estudo contribui para a ciência da enfermagem, a pesquisa e a prática clínica, uma vez que fornece suporte científico com discussão profunda do fenômeno, apresentando, de forma detalhada, os antecedentes, atributos e consequentes da violência obstétrica. Isso possibilita ao profissional de enfermagem reconhecer os indicadores empíricos do conceito; assim, é provável que ele conte com mais conhecimento que o conduza a uma assistência de enfermagem mais precisa, além de subsídios para prevenir a violência obstétrica.

Resumen Objetivo: analizar el concepto de violencia obstétrica en el marco de la Enfermería, desde la identificación de sus antecedentes, atributos y consecuentes. Materiales y método: se trata de un análisis conceptual, que sigue el método planteado por el modelo de Walker y Avant, el que consiste en ocho etapas. Para lograr el propósito del estudio, se emplearon seis etapas: selección del concepto; delimitación de los objetivos del análisis; identificación de los usos del concepto en la literatura; determinación de los atributos esenciales; identificación de los antecedentes y consecuentes del concepto, y definición de las referencias empíricas del concepto. Resultados: la muestra estuvo compuesta por 22 estudios. Se evidenciaron 31 antecedentes: 24 atributos para violencia física; 35, para psicológica/emocional; 6, para institucional; 6, para violencia sexual y 5, para violencia estructural. En cuanto a los consecuentes, se encontraron 39 elementos. Conclusiones: el estudio aporta a la ciencia de la Enfermería, la investigación y la práctica clínica, debido a que brinda soporte científico con discusión profunda acerca del fenómeno, además de presentar, de forma detallada, los antecedentes, atributos y consecuentes de la violencia obstétrica. Lo anterior posibilita al profesional de enfermería reconocer los indicadores empíricos del concepto; así, es probable que cuente con más conocimiento que lo conduzca a una atención en Enfermería más precisa, además de subsidios para prevenir la violencia obstétrica.

Abstract Objective: To analyze the concept of “Obstetric violence” in the Nursing context based on identifying its antecedents, attributes, and consequences. Materials and method: It is a conceptual analysis that follows the method proposed by the Walker and Avant model, which consists of eight stages. Six stages were used to contemplate the study objective, namely: selection of the concept; delimitation of the analysis objectives; identification of different uses of the concept in the literature; determination of the essential attributes; identification of the concept’s antecedents and consequents, and definition of the concept’s empirical references. Results: The sample was comprised of 22 studies. A total of 31 antecedents were evidenced: 24 attributes for physical violence; 35 for psychological/emotional violence; 6 for institutional and sexual violence, and 5 for structural violence. Regarding the consequences, 39 elements were found. Conclusions: The study contributes to Nursing science, research, and clinical practice, providing scientific support with a deep discussion of the phenomenon and presenting the antecedents, attributes, and consequences of obstetric violence in detail. It enables Nursing professionals to recognize the empirical indicators of the concept; thus, it is likely that they will have more knowledge that will lead them to more precise Nursing care, in addition to subsidies to prevent obstetric violence.

Objective: To estimate the mortality trend and analyze the potential years of life lost (PYLL) due to leukemias and lymphomas in Brazil and Mato Grosso, from 2001 to 2019. Methods: Time-series study of deaths from leukemias and lymphomas obtained from the Mortality Information System. Trends were calculated by age group by the Joinpoint regression method, using calendar year as regressor variable, and estimated annual percentage change (APC) and mean annual percentage change, considering 95% confidence intervals. APVP rates were collected from the Cancer Mortality Altas. Results: In Brazil, the mortality rate trend showed stability for both diseases, leukemias (APC=0.2; 95%CI-0.0;0.3) and lymphomas (APC=0.2; 95%CI-0.4;0.1). In the state, the rate for leukemias also showed stability (APC=0.3; 95%CI-1.0;1.6). For lymphomas, the trend was upward (APC=2.3; 95%CI0.5;4.2), however, decreasing trend was observed among those younger than 59 years. For leukemias, the APVP rates were 64 and 65/100,000 in Brazil and Mato Grosso, respectively. For lymphomas, these rates were 27 and 22/100,000, respectively, with the highest rates found in males. Conclusion: The mortality rates from leukemia and lymphoma in Mato Grosso show a behavior different from that observed nationally, with an increasing trend for lymphomas and no differences between age groups for both diseases. The APVP rates for leukemias were similar, however, for lymphomas, it was higher among men and lower for the state when compared to Brazil.

Objetivo: Estimar a tendência de mortalidade e analisar os anos potenciais de vida perdidos (APVP) por leucemias e linfomas no Brasil e Mato Grosso, entre os anos de 2001 a 2019. Métodos: Estudo de série temporal de óbitos por leucemias e linfomas obtidos do Sistema de Informações sobre Mortalidade. As tendências foram calculadas por faixa etária pelo método de regressão Joinpoint, usando ano calendário como variável regressora, e estimadas a variação percentual anual (APC) e variação percentual média anual, considerando intervalos de confiança de 95%. As taxas de APVP foram coletadas do Altas de Mortalidade por câncer. Resultados: No Brasil, a tendência da taxa de mortalidade apresentou estabilidade para ambos os agravos, leucemias (APC=0,2; IC95%-0,0;0,3) e linfomas (APC=0,2; IC95%-0,4;0,1). No estado, a taxa por leucemias também apresentou estabilidade (APC=0,3; IC95%-1,0;1,6). Para os linfomas, a tendência foi de aumento (APC=2,3; IC95%0,5;4,2), contudo, tendência decrescente foi observada entre aqueles com menos de 59 anos. Para leucemias, as taxas de APVP foram de 64 e 65/100.000 no Brasil e no Mato Grosso, respectivamente. Para linfomas, esses valores foram de 27 e 22/100.000, respectivamente, sendo as maiores taxas encontradas no sexo masculino. Conclusão: As taxas de mortalidade por leucemias e linfomas no Mato Grosso apresentam comportamento diferente do observado nacionalmente, com tendência crescente para linfomas e sem diferenças entre as faixas etárias, para ambos os agravos. As taxas de APVP por leucemias foram semelhantes, no entanto, para os linfomas, foi maior entre os homens e menores para o estado, quando comparadas as do Brasil.

Abstract Introduction: The increase in the incidence of pancreatic and biliary cancers has attracted the search for methods of early detection of diseases and biomarkers. The authors propose to analyze new findings on the association between microbiota and Pancreatic Ductal Adenocarcinoma (PDAC) or Cholangiocarcinoma (CCA). Methods: This systematic review was carried out according to the items of Preferred Reports for Systematic Reviews and Protocol Meta-Analysis (PRISMA-P). This study was registered by the Prospective Register of Systematic Reviews (PROSPERO), identification code CRD42020192748 before the review was carried out. Articles were selected from the PUBMED, EMBASE, and Cochrane databases. Results: Most studies (86.67%) used 16s rRNA as a sequencing method. The main comorbidities found were diabetes mellitus, systemic arterial hypertension, and dyslipidemia. Many studies were limited by the small number of participants, but the biases were mostly low. There was very little concordance about the composition of the microbiome of different sites, for both case and control groups when compared to other studies’ results. Bile sample analysis was the one with a greater agreement between studies, as three out of four studies found Escherichia in cases of CCA. Conclusion: There was great disagreement in the characterization of both the microbiota of cases and control groups. Studies are still scarce, making it difficult to adequately assess the data in this regard. It was not possible to specify any marker or to associate any genus of microbiota bacteria with PDAC or CCA.

RESUMO: Objetivos: Estimar a tendência de mortalidade e analisar os anos potenciais de vida perdidos (APVP) por leucemias e linfomas no Brasil e em Mato Grosso, entre os anos de 2001 e 2019. Métodos: Estudo de série temporal de óbitos por leucemias e linfomas obtidos do Sistema de Informação sobre Mortalidade. As tendências foram calculadas por faixa etária pelo método de regressão joinpoint, usando ano calendário como variável regressora, e estimaram-se a variação percentual anual (APC) e a variação percentual média anual, considerando intervalos de confiança de 95% (IC95%). As taxas de APVP foram coletadas do Atlas de Mortalidade por Câncer. Resultados: No Brasil, a tendência da taxa de mortalidade apresentou estabilidade para ambos os agravos, leucemias (APC=0,2; IC95% 0,0–0,3) e linfomas (APC=0,2; IC95% 0,4–0,1). No estado, a taxa por leucemias também apontou estabilidade (APC=0,3; IC95% 1,0–1,6). Para os linfomas, a tendência foi de aumento (APC=2,3; IC95% 0,5–4,2), contudo tendência decrescente foi observada entre aqueles com menos de 59 anos. Para leucemias, as taxas de APVP foram de 64 e 65/100 mil no Brasil e em Mato Grosso, respectivamente. Para linfomas, esses valores foram de 27 e 22/100 mil, respectivamente, sendo as maiores taxas encontradas no sexo masculino. Conclusão: As taxas de mortalidade por leucemias e linfomas em Mato Grosso apresentam comportamento diferente do observado nacionalmente, com tendência crescente para linfomas e sem diferenças entre as faixas etárias, para ambos os agravos. As taxas de APVP por leucemias foram semelhantes, no entanto para os linfomas foram maiores entre os homens e menores para o estado, quando comparadas com as do Brasil.

ABSTRACT: Objective: To estimate the mortality trend and to analyze the potential years of life lost (PYLL) due to leukemias and lymphomas in Brazil and Mato Grosso, from 2001 to 2019. Methods: Time-series study on deaths from leukemias and lymphomas with data obtained from the Mortality Information System. Trends were calculated by age group by the Joinpoint regression method, using calendar year as regressor variable, estimated annual percentage change (APC) and mean annual percentage change, considering 95% confidence intervals. PYLL rates were collected from the Cancer Mortality Atlas. Results: In Brazil, the mortality rate trend remained stable for both diseases in the period: leukemias (APC=0.2; 95%CI 0.0–0.3) and lymphomas (APC=0.2; 95%CI 0.4–0.1). In Mato Grosso state, the rate for leukemias was also stable (APC=0.3; 95%CI 1.0–1.6). For lymphomas, the trend was ascendant (APC=2.3; 95%CI 0.5–4.2), but descending among people younger than 59 years. For leukemias, PYLL rates were 64 and 65/100,000 in Brazil and Mato Grosso, respectively. For lymphomas, 27 and 22/100,000, respectively, with the highest rates found among males. Conclusion: The behavior of mortality rates from leukemia and lymphoma in Mato Grosso was different from that observed nationally, with an upward trend for lymphomas and no differences between age groups for both diseases. PYLL rates for leukemias were similar, while for lymphomas they were higher among men and lower in Mato Grosso when compared to Brazil.

ABSTRACT: Objective: To estimate the mortality trend and to analyze the potential years of life lost (PYLL) due to leukemias and lymphomas in Brazil and Mato Grosso, from 2001 to 2019. Methods: Time-series study on deaths from leukemias and lymphomas with data obtained from the Mortality Information System. Trends were calculated by age group by the Joinpoint regression method, using calendar year as regressor variable, estimated annual percentage change (APC) and mean annual percentage change, considering 95% confidence intervals. PYLL rates were collected from the Cancer Mortality Atlas. Results: In Brazil, the mortality rate trend remained stable for both diseases in the period: leukemias (APC=0.2; 95%CI 0.0–0.3) and lymphomas (APC=0.2; 95%CI 0.4–0.1). In Mato Grosso state, the rate for leukemias was also stable (APC=0.3; 95%CI 1.0–1.6). For lymphomas, the trend was ascendant (APC=2.3; 95%CI 0.5–4.2), but descending among people younger than 59 years. For leukemias, PYLL rates were 64 and 65/100,000 in Brazil and Mato Grosso, respectively. For lymphomas, 27 and 22/100,000, respectively, with the highest rates found among males. Conclusion: The behavior of mortality rates from leukemia and lymphoma in Mato Grosso was different from that observed nationally, with an upward trend for lymphomas and no differences between age groups for both diseases. PYLL rates for leukemias were similar, while for lymphomas they were higher among men and lower in Mato Grosso when compared to Brazil. ABSTRACT Objective (PYLL 200 2019 Methods Timeseries Time series System method variable APC (APC 95 intervals Atlas Results period APC=0.2 APC02 0 2 (APC=0.2 95CI CI 0.0–0.3 0003 3 0.4–0.1. 0401 0.4–0.1 . 4 1 0.4–0.1) state APC=0.3 APC03 (APC=0.3 1.0–1.6. 1016 1.0–1.6 6 1.0–1.6) APC=2.3 APC23 (APC=2.3 0.5–4.2, 0542 0.5–4.2 , 5 0.5–4.2) 65100000 65 100 000 65/100,00 respectively 22100000 22 22/100,000 males Conclusion nationally similar 20 201 9 APC=0. APC0 (APC=0. 0.0–0. 040 0.4–0. 101 1.0–1. APC=2. APC2 (APC=2. 054 0.5–4. 6510000 10 00 65/100,0 2210000 22/100,00 APC=0 (APC=0 0.0–0 04 0.4–0 1.0–1 APC=2 (APC=2 05 0.5–4 651000 65/100, 221000 22/100,0 APC= (APC= 0.0– 0.4– 1.0– 0.5– 65100 65/100 22100 22/100, 0.0 0.4 1.0 0.5 6510 65/10 2210 22/100 0. 1. 651 65/1 221 22/10 65/ 22/1 22/

RESUMO: Objetivos: Estimar a tendência de mortalidade e analisar os anos potenciais de vida perdidos (APVP) por leucemias e linfomas no Brasil e em Mato Grosso, entre os anos de 2001 e 2019. Métodos: Estudo de série temporal de óbitos por leucemias e linfomas obtidos do Sistema de Informação sobre Mortalidade. As tendências foram calculadas por faixa etária pelo método de regressão joinpoint, usando ano calendário como variável regressora, e estimaram-se a variação percentual anual (APC) e a variação percentual média anual, considerando intervalos de confiança de 95% (IC95%). As taxas de APVP foram coletadas do Atlas de Mortalidade por Câncer. Resultados: No Brasil, a tendência da taxa de mortalidade apresentou estabilidade para ambos os agravos, leucemias (APC=0,2; IC95% 0,0–0,3) e linfomas (APC=0,2; IC95% 0,4–0,1). No estado, a taxa por leucemias também apontou estabilidade (APC=0,3; IC95% 1,0–1,6). Para os linfomas, a tendência foi de aumento (APC=2,3; IC95% 0,5–4,2), contudo tendência decrescente foi observada entre aqueles com menos de 59 anos. Para leucemias, as taxas de APVP foram de 64 e 65/100 mil no Brasil e em Mato Grosso, respectivamente. Para linfomas, esses valores foram de 27 e 22/100 mil, respectivamente, sendo as maiores taxas encontradas no sexo masculino. Conclusão: As taxas de mortalidade por leucemias e linfomas em Mato Grosso apresentam comportamento diferente do observado nacionalmente, com tendência crescente para linfomas e sem diferenças entre as faixas etárias, para ambos os agravos. As taxas de APVP por leucemias foram semelhantes, no entanto para os linfomas foram maiores entre os homens e menores para o estado, quando comparadas com as do Brasil. RESUMO Objetivos (APVP 200 2019 Métodos joinpoint regressora estimaramse estimaram se APC (APC 95 IC95%. IC95 IC . (IC95%) Câncer Resultados agravos APC=0,2 APC02 0 2 (APC=0,2 0,0–0,3 0003 3 0,4–0,1. 0401 0,4–0,1 4 1 0,4–0,1) estado APC=0,3 APC03 (APC=0,3 1,0–1,6. 1016 1,0–1,6 6 1,0–1,6) APC=2,3 APC23 (APC=2,3 0,5–4,2, 0542 0,5–4,2 , 5 0,5–4,2) 65100 65 100 65/10 respectivamente 22100 22 22/10 masculino Conclusão nacionalmente etárias semelhantes 20 201 9 IC9 (IC95% APC=0, APC0 (APC=0, 0,0–0, 000 040 0,4–0, 101 1,0–1, APC=2, APC2 (APC=2, 054 0,5–4, 6510 10 65/1 2210 22/1 (IC95 APC=0 (APC=0 0,0–0 00 04 0,4–0 1,0–1 APC=2 (APC=2 05 0,5–4 651 65/ 221 22/ (IC9 APC= (APC= 0,0– 0,4– 1,0– 0,5– (IC 0,0 0,4 1,0 0,5 0, 1,

Abstract INTRODUCTION: The aac(6’)-Ib-cr and bla KPC genes are spreading among Enterobacteriaceae species, including Providencia stuartii, in some countries of world. METHODS: These genes were investigated in 28 P. stuartii isolates from a public hospital in Recife, Pernambuco, Brazil, by PCR and sequencing. RESULTS: The aac(6’)-Ib-cr gene was detected in 16 resistant isolates, and the bla KPC gene was seen in 14. CONCLUSIONS: The presence of these genes in P. stuartii multi- and extensively drug-resistant isolates indicates that the resistance arsenal of this species is increasing, thus limiting the therapeutic options.

Abstract Thyroid hormone has effects on the skin. Patients with hypothyroidism have changes such as dry, scaly and rough skin. Increase carotene in the dermis becomes a yellowish tone to the skin of the patient with hypothyroidism. There is an increase in capillary cycle (anagen phase) and nail growth and a reduction in eccrine gland secretion. It is a case of primary hypothyroidism with nail manifestations associated with dermatologic disorders and successful treatment with levothyroxine. Receptors for thyroid hormone have already been found in keratinocytes, fibroblasts, hair follicles and sebaceous glands. Genes responsive to thyroid hormones and elements of the hypothalamic–pituitary–thyroid axis were identified on the skin. This report highlights the importance of cutaneous manifestations as markers of thyroid disease.

ABSTRACT. The aim of this study was to evaluate the addition of macauba palm cake (Acrocomia aculeata) on the chemical composition, fermentation and aerobic stability of elephant grass silages (Pennisetum purpureum). The experiment was performed in a completely randomized design with four replicates. The treatments were composed of six levels of macauba palm cake (0, 6, 12, 18, 24, 30%) as additive to elephant grass silage. Dry matter and ethereal extract content of the silage increased linearly with the inclusion of the additive. Addition levels of 15.54% would provide 35% of dry mass, and the limit of 7.00% of ethereal extract in the silage could be obtained with 10.47%. The neutral detergent fiber content reduced linearly from 68.97 to 52.59%, but lignin increased linearly from 6.56 to 7.70%. There was a reduction of 0.17% in the ammoniacal nitrogen content for each 1% of cake. The minimum value of dry matter losses (1.33%) was estimated to the inclusion level of 23.70%. The aerobic stability increased with inclusions between 18 and 24% of cake. The use of levels between 10 and 15% of macauba palm cake are sufficient to optimize dry matter and ethereal extract contents of the silages and to provide a high aerobic stability with minimum losses.

ABSTRACT. Herbicides have been used to control Brachiaria grass in pastures established or in formation given their practicality, however their efficiency is questionable due to the lack of specific graminicides for different forage species. Therefore, the goal of this study was to evaluate the efficiency of glyphosate and fluazifop-p-butyl in the control of Brachiaria decumbens (signalgrass) and the intoxication levels of Panicum maximum cv. Tanzania (Tanzania quinea grass) in pasture establishment. The experiments were designed in randomized blocks, in a 2 × 5 × 4 factorial arrangement of two herbicides (fluazifop-p-butyl and glyphosate), five doses equivalent to the commercial dosage of each herbicide (0.25; 0.50; 1.00; 1.50; 200), and four evaluation times after herbicide application (15, 21, 30 and 45 days). There was interaction between doses and evaluation times. The dose 1.5 L ha-1 fluazifop-p-butyl provides efficient control of signalgrass, however, leads to high intoxication in Tanzania guinea grass. Glyphosate is efficient in the control of signalgrass even at the lowest dose (90 g ha-1), however, it causes high intoxication in Tanzania guinea grass, preventing its use in developing pastures. It can be concluded that fluazifop-p-butyl and glyphosate herbicides are not recommended for the control of B. decumbens, cv. Basilisk in developing pastures of Tanzania guinea grass.

ABSTRACT OBJECTIVE: To estimate the seroprevalence of SARS-CoV-2 in the state of Maranhão, Brazil. METHODS: A population-based household survey was performed, from July 27, 2020 to August 8, 2020. The estimates considered clustering, stratification and non-response. Qualitative detection of IgM and IgG antibodies was performed in a fully-automated Elecsys® Anti-SARS-CoV-2 electrochemiluminescence immunoassay on the Cobas® e601 analyzer (Roche Diagnostics). RESULTS: In total, 3,156 individuals were interviewed. Seroprevalence of total antibodies against SARS-CoV-2 was 40.4% (95%CI 35.6-45.3). Population adherence to non-pharmaceutical interventions was higher at the beginning of the pandemic than in the last month. SARS-CoV-2 infection rates were significantly lower among mask wearers and among those who maintained social and physical distancing in the last month compared to their counterparts. Among the infected, 26.0% were asymptomatic. The infection fatality rate (IFR) was 0.14%, higher for men and older adults. The IFR based on excess deaths was 0.28%. The ratio of estimated infections to reported cases was 22.2. CONCLUSIONS: To the best of our knowledge, the seroprevalence of SARS-CoV-2 estimated in this population-based survey is one of the highest reported. The local herd immunity threshold may have been reached or might be reached soon.