RESUMO Objetivo: Analisar a associação entre a participação em exercícios físicos relacionados ao fitness (EFRF) e a insatisfação com a imagem corporal (IIC) em adolescentes e avaliar a interação entre os exercícios físicos e o estado nutricional nesta associação. Métodos: Estudo transversal realizado em 2015 com 799 adolescentes (10 a 16 anos) de 14 escolas públicas de Curitiba (PR), Brasil. A IIC foi avaliada por meio do Body Shape Questionnaire e da Escala de Silhuetas. A participação em EFRF foi avaliada pelo Questionário de Atividade Física para Adolescentes e classificada em “não pratica”, “pratica ≤300 minutos/semana” e “pratica >300 minutos/semana”. As regressões de Poisson e logística multinomial, ajustadas por sexo, maturação sexual e estado nutricional, analisaram a associação entre EFRF e IIC. Resultados: A prevalência de IIC foi de 28,3%; 52,4% dos adolescentes queriam reduzir a silhueta e 48,7% não praticavam a EFRF. Adolescentes que praticavam EFRF >300 minutos/semana tiveram prevalência 28% maior para algum nível de IIC (razão de prevalência — RP 1,28; intervalo de confiança de 95% — IC95% 1,08–1,52) e chance 46% menor de querer reduzir silhuetas (OR 0,54; 95IC% 0,35–0,82), comparados aos não praticantes. Não houve interação entre os EFRF e o estado nutricional na associação com IIC. Conclusões: Os adolescentes que praticam EFRF >300 minutos/semana estão mais propensos a apresentar algum nível de IIC e têm menores chances de reportar o desejo de aumentar silhuetas, independentemente do estado nutricional. Objetivo (EFRF (IIC Métodos 201 79 10 (1 1 anos PR, PR , (PR) Brasil Silhuetas pratica, pratica pratica” 300 ≤30 minutossemana minutos semana >30 minutos/semana. . multinomial sexo Resultados 28,3% 283 28 3 524 52 4 52,4 487 48 7 48,7 razão 1,28 128 95 IC95 IC 1,08–1,52 108152 08 46 OR 0,54 054 0 54 95IC 0,35–0,82, 035082 0,35–0,82 35 82 0,35–0,82) praticantes Conclusões 20 ( (PR 30 ≤3 >3 28,3 2 5 52, 48, 1,2 12 9 IC9 1,08–1,5 10815 0,5 05 03508 0,35–0,8 8 ≤ > 28, 1, 1,08–1, 1081 0, 0350 0,35–0, 1,08–1 108 035 0,35–0 1,08– 03 0,35– 1,08 0,35 1,0 0,3

ABSTRACT Objective: The aim of this study was to analyze the association between participation in fitness-related exercises (FRE) and body image dissatisfaction (BID) in adolescents and evaluate the interaction between physical exercise and nutritional status in this association. Methods: A cross-sectional study was conducted in 2015 involving 799 adolescents (10–16 years old) from 14 public schools in Curitiba (PR), Brazil. BID was assessed using the Body Shape Questionnaire and the Silhouette Scale. The FRE was classified as “does not practice,” “practices ≤300 min/week,” and “practices >300 min/week” by the Physical Activity Questionnaire for Adolescents. Poisson and multinomial logistic regressions, adjusted for sex, sexual maturation, and nutritional status analyzed the association of FRE and BID. Results: The BID prevalence was 28.3%; 52.4% of the adolescents wanted to reduce their silhouettes; and 48.7% did not practice FRE. Adolescents who practiced FRE >300 min/week had a 28% higher prevalence for some level of BID (PR 1.28; 95%CI 1.08–1.52) and a 46% lower chance of wanting to reduce silhouettes (OR 0.54; 95%CI 0.35–0.82), compared to nonpractitioners. There was no interaction between FRE and nutritional status in association with BID. Conclusions: The adolescents who practice FRE >300 min/week are likely to have some level of BID and are less likely to report the desire to increase their silhouettes, regardless of their nutritional status. Objective fitnessrelated fitness related (FRE (BID Methods crosssectional cross sectional 201 79 10–16 1016 10 16 (10–1 old 1 PR, PR , (PR) Brazil Scale does practice, practices 300 ≤30 min/week, minweek min week >30 regressions sex maturation Results 28.3% 283 28 3 524 52 4 52.4 487 48 7 48.7 1.28 128 95CI CI 95 1.08–1.52 108152 08 46 OR 0.54 054 0 54 0.35–0.82, 035082 0.35–0.82 35 82 0.35–0.82) nonpractitioners Conclusions 20 10–1 101 (10– 30 ≤3 >3 28.3 2 5 52. 48. 1.2 12 9 1.08–1.5 10815 0.5 05 03508 0.35–0.8 8 10– (10 ≤ > 28. 1. 1.08–1. 1081 0. 0350 0.35–0. (1 1.08–1 108 035 0.35–0 ( 1.08– 03 0.35– 1.08 0.35 1.0 0.3

Resumo Antecedentes Dados acerca da prevalência da estenose arterial intracraniana (EAIC) entre os pacientes com acidente vascular isquêmico (AVCi) agudo no Brasil e América Latina são limitados. Objetivo O presente estudo pretendeu investigar a frequência e os preditores da EAIC nos pacientes AVCi ou ataque isquêmico transitório (AIT) em um centro brasileiro utilizando o Doppler transcraniano colorido (duplex transcraniano). Métodos Pacientes consecutivos com AVCi ou AIT, admitidos entre fevereiro e dezembro de 2014 em um centro acadêmico brasileiro especializado em doenças cerebrovasculares, foram avaliados prospectivamente com duplex transcraniano. Os estreitamentos vasculares > 50% foram considerados como EAIC, baseado em critérios ultrassonográficos definidos previamente na literatura. Resultados Foram avaliados 170 pacientes com AVCi ou AIT, dos quais 27 (15,9%) foram excluídos em decorrência da janela óssea transtemporal acústica inadequada. Confirmamos EAIC em 55 pacientes (38,5%). A localização mais comum foi o segmento proximal da artéria cerebral média (28,2%), seguida pelas artérias vertebral (15,4%), cerebral posterior (13,6%), carótida interna terminal (9,1%) e basilar (8,2%). No modelo multivariado, ajustado para os potenciais confundidores, a pressão arterial sistólica aumentada (OR: 1,03; IC 95%: 1,01–1,04; p = 0,008) foi independentemente associada a EAIC. Conclusão Foi identificada EAIC significativa em quase ⅓ dos pacientes admitidos com sintomas de AVCi ou AIT em um serviço acadêmico público de atendimento especializado em doenças cerebrovasculares. O Doppler transcraniano colorido é uma ferramenta acessível e não invasiva que pode ser utilizada com segurança para a investigação da presença de EAIC moderada ou grave, especialmente nos pacientes que não podem ser expostos a exames complementares mais invasivos com uso de contraste intravenoso. (EAIC (AVCi limitados (AIT . transcraniano) 201 cerebrovasculares 50 literatura 17 2 15,9% 159 15 9 (15,9% inadequada 5 38,5%. 385 38,5% 38 (38,5%) 28,2%, 282 28,2% , 28 (28,2%) 15,4%, 154 15,4% 4 (15,4%) 13,6%, 136 13,6% 13 6 (13,6%) 9,1% 91 1 (9,1% 8,2%. 82 8,2% 8 (8,2%) multivariado confundidores OR (OR 1,03 103 03 95% 95 1,01–1,04 101104 01 04 0,008 0008 0 008 grave intravenoso 20 15,9 (15,9 38,5 3 (38,5% 28,2 (28,2% 15,4 (15,4% 13,6 (13,6% 9,1 (9,1 8,2 (8,2% 1,0 10 1,01–1,0 10110 0,00 000 00 15, (15, 38, (38,5 28, (28,2 (15,4 13, (13,6 9, (9, 8, (8,2 1, 1,01–1, 1011 0,0 (15 (38, (28, (13, (9 (8, 1,01–1 101 0, (1 (38 (28 (13 ( (8 1,01– (3 (2 1,01

Abstract Background There is limited data available regarding the prevalence of intracranial arterial stenosis (ICAS) among acute ischemic stroke (AIS) patients in Brazil and Latin America. Objective The present study sought to investigate the frequency and predictors of ICAS among patients with AIS or transient ischemic attack (TIA) in a Brazilian center, with transcranial color-coded duplex sonography (TCCS) technique. Methods Consecutive AIS and TIA patients, admitted to an academic public comprehensive stroke center in Brazil from February to December 2014, evaluated by TCCS were prospectively selected. Vascular narrowings > 50% were considered as ICAS, based on ultrasound criteria previously defined in the literature. Results We assessed 170 consecutive patients with AIS or TIA, of whom 27 (15.9%) were excluded due to an inadequate transtemporal acoustic bone window. We confirmed ICAS in 55 patients (38.5%). The most common location was the proximal segment of the middle cerebral artery (28.2%), followed by the vertebral (15.4%), posterior cerebral (13.6%), terminal internal carotid (9.1%) and basilar (8.2%) arteries. On multivariate models adjusting for potential confounders, systolic blood pressure (OR: 1.03, 95%CI: 1.01–1.04; p = 0.008) was independently associated with ICAS. Conclusion We found significant ICAS in approximately ⅓ of patients admitted with symptoms of AIS or TIA in a public tertiary academic stroke center in Brazil. The TCCS is an accessible and noninvasive technique that can be used to investigate the presence of moderate and severe ICAS, especially in patients who cannot be exposed to more invasive exams, such as the use of intravenous contrast agents. (ICAS (AIS America (TIA colorcoded color coded (TCCS 2014 selected 50 literature 17 2 15.9% 159 15 9 (15.9% window 5 38.5%. 385 38.5% . 38 (38.5%) 28.2%, 282 28.2% , 28 (28.2%) 15.4%, 154 15.4% 4 (15.4%) 13.6%, 136 13.6% 13 6 (13.6%) 9.1% 91 1 (9.1% 8.2% 82 8 (8.2% arteries confounders OR (OR 103 03 1.03 95%CI 95CI CI 95 1.01–1.04 101104 01 04 0.008 0008 0 008 exams agents 201 15.9 (15.9 38.5 3 (38.5% 28.2 (28.2% 15.4 (15.4% 13.6 (13.6% 9.1 (9.1 8.2 (8.2 10 1.0 1.01–1.0 10110 0.00 000 00 20 15. (15. 38. (38.5 28. (28.2 (15.4 13. (13.6 9. (9. 8. (8. 1. 1.01–1. 1011 0.0 (15 (38. (28. (13. (9 (8 1.01–1 101 0. (1 (38 (28 (13 ( 1.01– (3 (2 1.01

Abstract We hypothesized that the hCG modulates the expression of IFNT-pathway and ISGs in bovine endometrium during early pregnancy. The aim of the current study is to evaluate the effect of hCG on IFNT-pathway signals and ISGs expression in endometrial cells. For this, 29 non-lactating cross-bread cows were used in the study and submitted to a 9-day fixed-time artificial insemination (FTAI) protocol. The day of the AI was considered Day 0 (D0), and five days (D5) after the FTAI, the cows were allocated into two groups: Control and hCG group, when a hCG group received a single dose of 2.500UI of hCG. On day 18 after FTAI (D18) cows were slaughtered and endometrial tissue samples were collected. There was no difference between the embryo recovery rate of the cows in C compared to the hCG. The hCG group increased the accessory corpus luteum formation rate. The hCG resulted in greater serum progesterone concentration in the hCG group compared to the C on Day 14. Only the expression of IFNAR2 and STAT1 were upregulated on pregnant cows of the hCG group compared to the C group. The pathway genes (JAK1, STAT2, and IRF9) were not regulated. The mRNA abundance of ISG15, MX1, MX2, and OAS1 was upregulated in pregnant cows for hCG group, compared to C group. The results show that the administration of hCG, 5 days after AI, in addition to increasing the serum progesterone, modulates the expression of IFNT-pathway and ISGs on bovine endometrium on Day 18 of pregnancy. IFNTpathway IFNT pregnancy cells this 2 nonlactating non lactating crossbread cross bread 9day 9 fixedtime fixed time (FTAI protocol D0, D0 D , (D0) D5 (D5 groups 2500UI UI 500UI 1 D18 (D18 collected 14 IFNAR STAT JAK1, JAK1 JAK (JAK1 STAT2 IRF9 IRF regulated ISG15 ISG MX1 MX MX2 OAS (D0 (D D1 (D1 (JAK ISG1

ABSTRACT Objective Currently programmed cell death protein 1 (PD-1) inhibitors in combination with other therapies are being evaluated to determine their efficacy in cancer treatment. However, the effect of PD-ligand (L) 1 expression on disease outcomes in stage III (EC III) non-small cell lung cancer is not completely understood. Therefore, this study aimed to assess the influence of PD-L1 expression on the outcomes of EC III non-small cell lung cancer. Methods This study was conducted on patients diagnosed with EC III non-small cell lung cancer who underwent treatment at a tertiary care hospital. PD-L1 expression was determined using immunohistochemical staining, all patients expressed PD-L1. Survival was estimated using the Kaplan-Meier method. Relationships between variables were assessed using Cox proportional regression models. Results A total of 49 patients (median age=69 years) with EC III non-small cell lung cancer and PD-L1 expression were evaluated. More than half of the patients were men, and most were regular smokers. The patients were treated with neoadjuvant chemotherapy, surgery, or sequential or combined chemotherapy and radiotherapy. The median progression-free survival of the entire cohort was 14.2 months, and the median overall survival was 20 months. There was no significant association between PD-L1 expression and disease progression, clinical characteristics, or overall survival. Conclusions PD-L1 expression was not correlated with EC III non-small cell lung cancer outcomes. Whether these findings differ from the association with immune checkpoint inhibitors remains to be addressed in future studies. PD1 PD (PD-1 However PDligand ligand L (L nonsmall non small understood Therefore PDL1 PDL L1 PD-L hospital staining PDL1. L1. KaplanMeier Kaplan Meier method models 4 age69 age 69 age=6 years men smokers surgery radiotherapy progressionfree progression free 142 14 2 14. months characteristics studies (PD- age6 6 age= (PD

Resumo Introdução O impacto do desnível da plataforma switching na estabilidade óssea ainda não é conhecido. Objetivo O objetivo deste estudo foi avaliar o efeito de diferentes desníveis (mismatchings) da plataforma switching na estabilidade óssea ao redor de implante com uma conexão Morse de angulação interna modificada (16°) após 4 a 11 meses do carregamento protético. Material e método Os implantes foram avaliados em dois períodos experimentais (momento da instalação e carregamento protético e no momento da visita de manutenção – após 4 a 11 meses do carregamento protético). As varáveis avaliadas foram o nível ósseo avaliado através de radiografia periapical e a taxa de sobrevivência destes implantes. O nível ósseo peri-implantar também foi avaliado de acordo com o diâmetro utilizado. Resultado 119 implantes dentários instalados em 45 pacientes foram avaliados. Destes implantes, 33 apresentaram diâmetro de 3.5mm, 33 implantes apresentaram 3.75mm e 19 apresentaram 4.0mm de diâmetro. A variação na perda óssea destes implantes foi de 0.36 ± 0.34 mm. O índice de correlação entre os diâmetros do implante e a perda óssea peri-implantar foi r=0.01, com um valor de p=0.22. Esses achados indicam que a correlação entre a variação do nível ósseo peri-implantar e o diâmetro do implante não foi significativa. A taxa de sobrevivência total da amostra foi de 97,47%. Conclusão Implantes com conexão Morse com angulação interna de 16° boas taxas de sobrevivência em curto prazo de acompanhamento, apresentando perda óssea limitada, a qual não foi influenciada pelos diferentes desníveis provocados pelo diâmetro do implante. conhecido mismatchings (mismatchings 16 (16° 1 . protético) periimplantar peri implantar utilizado 3 35mm mm 5mm 3.5mm 375mm 75mm 40mm 0mm 036 0 36 0.3 034 34 r001 r 01 r=0.01 p022 p 22 p=0.22 significativa 9747 97 47 97,47% acompanhamento limitada (16 03 0. r00 r=0.0 p02 2 p=0.2 974 9 97,47 (1 r0 r=0. p0 p=0. 97,4 ( r=0 p=0 97, r= p=

Abstract Introduction The impact of switching platform unevenness on bone stability is not yet known. Objective The aim of this study was to evaluate the effect of different mismatching of platform switching on the bone stability around implants with a Morse taper with internal angulation of 16º after 4-11 months of prosthetic loading. Material and method The implants were evaluated in two experimental periods (implant installation time and loading, and maintenance visit – after between 4 and 11 months of prosthetic loading). The variables evaluated were the bone level assessed by periapical radiography, and the survival rates of the dental implants. The peri-implant bone level was also evaluated according to the diameter of the implants used. Result One hundred and nineteen dental implants placed in 45 patients were evaluated. Of these implants, 33 presented a 3.5mm diameter, 33 a 3.75mm diameter, 19 a 4.0 mm diameter, and 34 a 4.3 mm diameter. The variation in bone loss from these implants was 0.36 ± 0.34 mm. The correlation index between the implant diameters and peri implant bone loss was r = 0.01, with a p value = 0.22. This finding indicates that the correlation between the variation in peri-implant bone level and the implant diameter was not significant. The survival rate of the total sample was 97.47%. Conclusion Implants with a Morse taper connection and 16º internal angulation presented good early survival rates with limited bone loss, that was not influenced by the degree of platform switching. known º 411 4-1 loading 1 . loading) radiography periimplant used 3 35mm 5mm 375mm 75mm 40 0 4. 43 036 36 0.3 034 001 01 0.01 022 22 0.22 significant 9747 97 47 97.47% 41 4- 03 0. 00 0.0 02 2 0.2 974 9 97.47 97.4 97.

Resumo: Este artigo verifica se há evidências de intensificação do processo de desindustrialização no Brasil - dado o período recente mundial caracterizado como pandemia da COVID-19 -e investiga o papel da indústria de transformação no crescimento econômico via leis de Kaldor-Verdoorn. Os resultados indicam suporte para as leis de Kaldor e que há indícios de intensificação do processo de desindustrialização da economia brasileira durante a pandemia da COVID-19, destacando a importância da adoção de estratégias que foquem na reversão desse processo e que, possibilite, dessa forma, maiores taxas de crescimento econômico.

Abstract: This article verifies if there is evidence of intensification of the deindustrialization process in Brazil -given the recent world period characterized as the COVID-19 pandemic - and investigates the role of the manufacturing industry in economic growth via Kaldor-Verdoorn laws. Te results indicate support for Kaldor's laws and that there are indications of the intensification of the process of deindustrialization of the Brazilian economy during the COVID-19 pandemic, highlighting the importance of adopting strategies that focus on reversing this process and that, in this way, enable, higher rates of economic growth.

Aim To compare the profile and overall survival of young adults and elderly people diagnosed with SCC. Methods A retrospective study was carried out at a High Complexity Oncology Unit, between 2010 and 2016. A descriptive analysis, a bivariate analysis using the chi-square and Fisher’s exact test and the Kaplan-Meier estimator were performed. The predictor variables were tested using the log-rank test and those with statistical significance and the literature were maintained for the Cox regression model. Results 282 cases of SCC were recorded, with only 12.4% diagnosed in young adults. The profile was similar between groups, with the majority of cases of the disease occurring in males, smokers and alcohol consumers. The lesions predominantly located on the tongue and were diagnosed in an advanced stage of the disease, resulting in 35.7% of deaths. The median survival time was 30 months in the elderly and 31 months in young people. In the multivariate analysis, age was not statistically significant, only staging and treatment were predictors of reduced overall survival. Conclusion Tumor staging, and treatment were prognostic factors for the disease.

Resumen Introducción: El trauma es la segunda causa de mortalidad y la sexta de hospitalización en el país, siendo la violencia, los accidentes y las caídas las más prevalentes. Sin embargo, el país está experimentando reflejos de una pandemia de COVID-19, junto a una falta de estudios sobre el trauma, así como sobre la atención clínica. Objetivo: Analizar las características clínicas y epidemiológicas del trauma junto a la violencia, accidentes y caídas entre los años 2019, 2020 y 2021, considerados antes y durante la pandemia COVID-19. Materiales y métodos: Estudio de cohorte retrospectivo, con adultos de 25 a 55 años, que sufrieron trauma relacionado con violencia, caídas y otros accidentes, en el período comprendido entre marzo y junio de 2019, 2020 y 2021, en la ciudad de São Paulo. Las encuestas de datos fueron realizadas por el sistema TABNET, por el Departamento Municipal de Salud. Dentro de este sistema, la búsqueda se realizó a través del Sistema de Información para la Vigilancia de Accidentes, de la Coordinación de Vigilancia en Salud, en el cual las situaciones de violencia fueron notificadas y registradas por el Sistema Nacional de Información de Enfermedades Notificables. Posteriormente, se accedió al Sistema de Información de Vigilancia de Violencia y Accidentes, con enfoque en notificaciones y registro de caídas y otros accidentes. Resultados: El trauma siguió siendo más prevalente para los hombres, con educación primaria completa y raza predominantemente entre blancos y morenos. Al analizar los diferentes tipos de violencia: física, tortura y sexual, hubo mayores porcentajes de prevalencia durante el año 2019, período prepandémico de COVID-19, a excepción de la violencia psicológica / moral, que fue mayor en 2021. Nótese que los diferentes mecanismos de violencia fueron significativamente más prevalentes en 2019, así como las diferentes causas de violencia, caídas y traumatismos automovilísticos que involucran a peatones, ocupantes, conductores y pasajeros. La atención ambulatoria confirmó la tendencia de superioridad en el período prepandémico, sin embargo, la atención hospitalaria de emergencia mostró un mayor número de solicitudes en 2020 y 2021. Conclusión: Los traumas de violencia, accidentes y caídas son más prepandémico en comparación con el período durante la pandemia COVID-19; así como la búsqueda de asistencia sanitaria en hospitales y clínicas. Estos hallazgos muestran una posible reducción en los informes de trauma y una menor demanda de asistencia durante la pandemia.

Abstract Introduction: Trauma is the second leading cause of mortality and the sixth leading cause of hospitalization in the country, with violence, accidents, and falls being the most prevalent. However, the country is experiencing reflexes of the COVID-19 pandemic, together with a lack of studies on trauma, as well as on clinical care. Objective: To analyze the clinical and epidemiological characteristics of trauma related to violence, accidents, and falls among the years 2019, 2020, and 2021, considered as before and during the COVID-19 pandemic. Material and Methods: Retrospective cohort study, with adults aged 25-55 years, who suffered trauma related to violence, falls, and other accidents, in the period between March and June of 2019, 2020, and 2021, in the city of São Paulo. Data surveys were carried out using the TABNET system, of the Municipal Health Department. Within this system, the search was carried out through the Information System for the Surveillance of Accidents, of the Coordination of Health Surveillance, in which situations of violence were notified and recorded by the National Information System for Notifiable Diseases. Subsequently, the Information System for Surveillance of Violence and Accidents was accessed, focusing on notifications and records of falls and other accidents. Results: Trauma remained more prevalent for males, with complete primary education, and ethnicity predominantly between white or brown. When analyzing the different types of violence: physical, torture, and sexual, there was a prevalence of higher percentages during the year 2019, the pre-pandemic period of COVID-19, except for psychological/moral violence, which was higher in 2021. It should also be noted that the different mechanisms of violence were significantly more prevalent in 2019, as well as the different causes of violence, falls, and car trauma involving pedestrians, occupants, drivers, and passengers. Outpatient care confirmed the higher trend in the pre-pandemic period; however, emergency hospital care showed a greater number of requests in 2020 and 2021. Conclusión: Trauma from violence, accidents, and falls was higher pre-pandemic compared to the period during the COVID-19 pandemic; as well as the search for health care in hospitals and outpatient clinics. These findings show a possible reduction in trauma reports and lower demand for assistance during the pandemic.