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Formação para o Sistema Único de Saúde (SUS) na residência em área profissional da saúde: análise dos efeitos da política em um contexto estadual
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Santos, Juliana Siqueira

; Santos Neto, Pedro Miguel dos

Interface - Comunicação, Saúde, Educação

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2024, Volume 28 elocation e230587

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

Este artículo analiza el contexto de los efectos de la política de residencia en área profesional de la salud en el estado de Pernambuco, Brasil, por medio del referencial teórico-analítico del Abordaje del Ciclo de Políticas. Se trata de un estudio cualitativo que utilizó una entrevista semiestructurada con nueve actores clave y una investigación documental, analizados por medio del análisis de contenido temático. Como resultados de la política, se observó: fortalecimiento del papel del Sistema Brasileño de Salud (SUS) en la regulación de la formación; elevada calificación de los profesionales de salud; calidad del cuidado y ampliación del acceso. La inversión en la implementación de la política, como locus privilegiado de articulación entre enseñanza, servicio y comunidad, potencia el alcance de la integralidad de la atención, al mismo tiempo que contribuye para hacer que avancen los cambios necesarios en la formación superior en salud y en las prácticas de cuidado, aunque persistan límites.

Using the policy cycle approach, this study analyzed the effects of health residency policy in the state of Pernambuco, Brazil. We conducted a qualitative study using semi-structured interviews with nine key actors and document research. The data were analyzed using thematic content analysis. The following policy results were observed: strengthening of the Brazilian National Health System (SUS) role in the regulation of training; an increase in the level of qualification of health professionals; improvements in health care quality and access. Despite limitations, investment in the implementation of the policy as the locus of coordination between teaching, service and community enhances the reach of the comprehensiveness of care while at the same time driving the necessary changes to higher education in health and care practices.

Este artigo analisa o contexto dos efeitos da política de residência em área profissional da saúde no estado de Pernambuco, Brasil, por meio do referencial teórico-analítico da Abordagem do Ciclo de Políticas. Trata-se de um estudo qualitativo que utilizou entrevista semiestruturada com nove atores-chave e pesquisa documental, explorada pela análise de conteúdo temática. Como resultados da política, observaram-se: fortalecimento do papel do Sistema Único de Saúde (SUS) na regulação da formação, elevada qualificação dos profissionais de saúde, qualidade do cuidado e ampliação do acesso. O investimento na implementação da política, enquanto lócus privilegiado de articulação entre ensino, serviço e comunidade, potencializa o alcance da integralidade da atenção ao mesmo tempo que contribui para avançar as mudanças necessárias na formação superior em Saúde e nas práticas de cuidado, ainda que persistam limites.

https://doi.org/10.1590/interface.230587

Formação para o Sistema Único de Saúde (SUS) na residência em área profissional da saúde: análise dos efeitos da política em um contexto estadual SUS (SUS saúde
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Santos, Juliana Siqueira

; Santos Neto, Pedro Miguel dos

Interface - Comunicação, Saúde, Educação

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2024, Volume 28 elocation e230587

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/interface.230587

Residências em saúde: análise de uma política estadual de formação de profissionais para o SUS saúde
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Santos, Juliana Siqueira

; Santos Neto, Pedro Miguel dos

Saúde em Debate

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sep 2023, Volume 47 N. 138 Pages 516 - 530

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO As residências em saúde constituem-se importante estratégia de Estado na regulação da formação de profissionais para o Sistema Único de Saúde (SUS) no âmbito da política de gestão do trabalho e educação na saúde. Foi realizada uma investigação que objetivou analisar como a política de residência em área profissional da saúde tem sido implementada no estado de Pernambuco, Brasil, no período de 2010 a 2021, nos aspectos gestão, características dos programas de residência e recursos investidos. O trabalho é uma pesquisa social, do tipo estudo de caso e abordagem de métodos mistos, com pesquisa documental e dados governamentais, que utilizou como referencial teórico-analítico a Abordagem do Ciclo de Políticas. Foi desenvolvida análise de conteúdo temática com base no que foi coletado, na teoria e na perspectiva dos pesquisadores, identificando as categorias: atores da política e governança; expansão da formação e financiamento; áreas temáticas prioritárias; formação nas residências multiprofissionais em saúde. Foram identificadas experiências de gestão com participação dos diversos atores locais, investimento incremental em bolsas de residência e ampliação das residências multiprofissionais em saúde. Persiste o desafio de implementar uma política de formação em saúde, que, pautada pelo ensino em serviço, atue como força motriz para fazer avançar o SUS. constituemse constituem se SUS (SUS Pernambuco Brasil 201 2021 investidos social mistos governamentais teóricoanalítico teórico analítico Políticas coletado pesquisadores categorias governança financiamento prioritárias locais serviço 20 202 2

ABSTRACT Health residencies constitute an important State strategy in regulating the training of professionals for the Unified Health System (SUS) within the scope of work management and health education policy. An investigation was carried out to analyze how the residency policy in the professional health area has been implemented in the state of Pernambuco, Brazil, from 2010 to 2021, in terms of management, characteristics of residency programs, and resources invested. The work is a social research, of the case study type and mixed methods approach, with documental research and government data, which used the Policy Cycle Approach as a theoretical-analytical framework. We developed thematic content analysis based on what was collected, on theory and on the researchers’ perspective, identifying the categories: policy actors and governance; expansion of training and funding; priority thematic areas; training in multiprofessional health residencies. We identified management experiences with the participation of different local actors, incremental investment in residency grants, and expansion of multiprofessional residencies in health. The challenge of implementing a health training policy remains, which, based on in-service education, acts as a driving force to advance the SUS. SUS (SUS Pernambuco Brazil 201 2021 programs invested approach data theoreticalanalytical theoretical analytical framework collected researchers perspective categories governance funding areas grants remains inservice service 20 202 2

https://doi.org/10.1590/0103-1104202313811

Residências em saúde: análise de uma política estadual de formação de profissionais para o SUS
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Santos, Juliana Siqueira

; Santos Neto, Pedro Miguel dos

Saúde em Debate

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sep 2023, Volume 47 N. 138 Pages 516 - 530

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/0103-1104202313811

Update of the Brazilian consensus recommendations on Duchenne muscular dystrophy
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Araujo, Alexandra Prufer de Queiroz Campos

; Saute, Jonas Alex Morales

; Fortes, Clarisse Pereira Dias Drumond

; França Jr, Marcondes Cavalcante

; Pereira, Jaqueline Almeida

; Albuquerque, Marco Antonio Veloso de

; Carvalho, Alzira Alves de Siqueira

; Cavalcanti, Eduardo Boiteux Uchôa

; Covaleski, Anna Paula Paranhos Miranda

; Fagondes, Simone Chaves

; Gurgel-Giannetti, Juliana

; Gonçalves, Marcus Vinicius Magno

; Martinez, Alberto Rolim Muro

; Coimbra Neto, Antônio Rodrigues

; Neves, Flavio Reis

; Nucci, Anamarli

; Nucera, Ana Paula Cassetta dos Santos

; Pessoa, Andre Luis Santos

; Rebel, Marcos Ferreira

; Santos, Flavia Nardes dos

; Scola, Rosana Herminia

; Sobreira, Cláudia Ferreira da Rosa

Arquivos de Neuro-Psiquiatria

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jan 2023, Volume 81 N. 1 Pages 81 - 94

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Nas últimas décadas, houve progressos significativos no diagnóstico e no tratamento da distrofia muscular de Duchenne (DMD), considerada a distrofia muscular mais comum na infância. Diretrizes internacionais foram publicadas e revisadas recentemente. Um grupo de especialistas brasileiros desenvolveu um padrão de atendimento baseado em revisão de literatura, com recomendações graduadas pautadas em evidências compiladas em uma publicação dividida em duas partes. A implementação de melhores práticas de manejo ajudou a modificar a história natural desta doença crônica, progressiva, que, no passado, oferecia uma expectativa de vida muito limitada para crianças do sexo masculino. Desde a publicação desse consenso anterior, o diagnóstico, o tratamento com esteroides, a reabilitação e os cuidados sistêmicos ganharam novas possibilidades a partir da divulgação dos resultados de trabalhos originais em algumas dessas áreas. Além disso, as pesquisas e o desenvolvimento de novos fármacos estão em andamento, e algumas intervenções já foram aprovadas para uso em determinados países. Nesse contexto, identificamos a necessidade de rever as recomendações anteriores sobre o manejo dos pacientes brasileiros com DMD. Nosso objetivo principal foi elaborar uma atualização baseada em evidências sobre esses tópicos do consenso. décadas DMD, DMD , (DMD) infância recentemente literatura partes crônica progressiva que passado masculino anterior esteroides áreas disso andamento países contexto (DMD

Abstract In the last few decades, there have been considerable improvements in the diagnosis and care of Duchenne muscular dystrophy (DMD), the most common childhood muscular dystrophy. International guidelines have been published and recently reviewed. A group of Brazilian experts has developed a standard of care based on a literature review with evidence-based graded recommendations in a two-part publication. Implementing best practice management has helped change the natural history of this chronic progressive disorder, in which the life expectancy for children of the male sex in the past used to be very limited. Since the previous publication, diagnosis, steroid treatment, rehabilitation, and systemic care have gained more significant insights with new original work in certain fields. Furthermore, the development of new drugs is ongoing, and some interventions have been approved for use in certain countries. Therefore, we have identified the need to review the previous care recommendations for Brazilian patients with DMD. Our objective was to create an evidence-based document that is an update on our previous consensus on those topics. decades DMD, DMD , (DMD) reviewed evidencebased evidence twopart two part publication disorder limited treatment rehabilitation fields Furthermore ongoing countries Therefore topics (DMD

https://doi.org/10.1055/s-0043-1761466

Diabetes among women with preterm births: outcomes of a Brazilian multicenter study births
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Santos, Juliana da Costa

; Guida, José Paulo Siqueira

; Cralcev, Christopher

; Dias, Tabata Zumpano

; Passini Junior, Renato

; Lajos, Giuliane Jesus

; Pacagnella, Rodolfo Carvalho

; Tedesco, Ricardo Porto

; Nomura, Marcelo Luis

; Rehder, Patricia Moretti

; Cecatti, José Guilherme

; Costa, Maria Laura

einstein (São Paulo)

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2023, Volume 21 elocation eAO0515

Abstract: En | Text: En | PDF: En

ABSTRACT Objective The objective was to compare the maternal and perinatal characteristics and outcomes between women with and without diabetes in a Brazilian cohort of women with preterm births. Methods This was an ancillary analysis of the Brazilian Multicenter Study on Preterm Birth, which included 4,150 preterm births. This analysis divided preterm births into two groups according to the presence of diabetes; pregestational and gestational diabetes were clustered in the same Diabetes Group. Differences between both groups were assessed using χ 2 or Student’s t tests. Results Preterm births of 133 and 4,017 women with and without diabetes, respectively, were included. The prevalence of diabetes was 3.2%. Pregnant women aged ≥35 years were more common in the Diabetes Group (31.6% versus 14.0% non-diabetic women, respectively). The rate of cesarean section among patients with diabetes was 68.2% versus 52.3% in non-diabetic cases), with a gestational age at birth between 34 and 36 weeks in 78.9% of the cases and 62.1% of the controls. Large-for-gestational-age babies were 7 times more common in the Diabetes Group. Conclusion Preterm birth among Brazilian women with diabetes was more than twice as prevalent; these women were older and had regular late preterm deliveries, usually by cesarean section. They also had a greater frequency of fetal morbidities, such as malformations and polyhydramnios, and a higher proportion of large-for-gestational-age and macrosomic neonates. Birth 4150 4 150 4,15 Students Student s tests 13 4017 017 4,01 respectively 32 3 3.2% 35 ≥3 31.6% 316 31 6 (31.6 140 14 0 14.0 nondiabetic non diabetic respectively. . respectively) 682 68 68.2 523 52 52.3 cases, , cases) 789 78 9 78.9 621 62 1 62.1 controls Largeforgestationalage Large for prevalent deliveries morbidities polyhydramnios largeforgestationalage large neonates 415 15 4,1 401 01 4,0 3.2 ≥ 31.6 (31. 14. 68. 5 52. 78. 62. 41 4, 40 3. 31. (31 (3 (

https://doi.org/10.31744/einstein_journal/2023ao0515

Implications of the COVID-19 pandemic in monitoring health and cardiovascular diseases: survey study COVID19 COVID 19 COVID-1 diseases COVID1 1 COVID-
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Machado, Juliana Pereira

; Costa, Bárbara Caroliny Pereira

; Sudré, Mayara Rocha Siqueira

; Santos, Isabela Gomes Musa dos

; Veiga, Eugenia Velludo

Revista da Escola de Enfermagem da USP

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2023, Volume 57 elocation e20220112

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

RESUMEN Objetivo: Analizar las implicaciones de la COVID-19 en el seguimiento de la salud y las enfermedades cardiovasculares en los servicios de salud. Método: Estudio descriptivo, transversal, encuesta, con 798 adultos, seleccionados en bola de nieve en las redes sociales, entre junio y julio de 2020. Los datos fueron recolectados en un formulario electrónico validado para este estudio. Resultados: Hubo un impacto negativo en el seguimiento de la salud y enfermedades cardiovasculares con citas perdidas y exámenes electivos. Síntomas como dolor torácico y crisis hipertensiva fueron desatendidas por miedo al contagio, desconocimiento o carencia estructural de servicios, además del deterioro del seguimiento de las condiciones crónicas. Conclusión: Hay gravedad en los resultados ante la evolución de la COVID-19 y el riesgo de complicaciones. Es necesario organizar flujos y estructuras compatibles con cada perfil de atención, en los servicios de salud, para garantizar la atención y promover el diagnóstico y control de las condiciones crónicas en el conjunto de acciones para la contención de pandemias. Es crucial priorizar la atención primaria en los seguimientos de salud durante los períodos de pandemia, ya que esto tiene un impacto directo en la evolución de las condiciones críticas en otros niveles de atención. Objetivo COVID19 COVID 19 COVID-1 Método descriptivo transversal encuesta 79 adultos sociales 2020 estudio Resultados electivos contagio Conclusión complicaciones pandemias pandemia COVID1 1 COVID- 7 202 20 2

ABSTRACT Objective: To analyze the implications of COVID-19 in the monitoring of health and cardiovascular diseases in health services. Method: This is a descriptive, cross-sectional, survey-type study with 798 adults, selected by snowball on social networks, between June and July 2020. Data were collected in an electronic form validated for this study. Results: There was a negative impact on monitoring health and cardiovascular diseases with missed appointments and elective exams. Symptoms such as chest pain and hypertensive crisis were neglected due to fear of contagion, lack of knowledge or structural lack of services, in addition to impaired monitoring of chronic conditions. Conclusion: The severity of results is noted considering the COVID-19 progression and the risk of complications. It is necessary to organize flows and structures compatible with each care profile, in health services, to guarantee care and promote diagnosis and control of chronic conditions in the set of actions to contain pandemics. It is crucial to prioritize primary care in health follow-ups during pandemic periods, as this has a direct impact on the progression of critical conditions at other levels of care. Objective COVID19 COVID 19 COVID-1 services Method descriptive crosssectional, crosssectional cross sectional, sectional cross-sectional surveytype survey type 79 adults networks 2020 Results exams contagion Conclusion complications profile pandemics followups follow ups periods COVID1 1 COVID- 7 202 20 2

RESUMO Objetivo: Analisar as implicações da COVID-19 no acompanhamento de saúde e doenças cardiovasculares em serviços de saúde. Método: Estudo descritivo, transversal, tipo survey, com 798 adultos, selecionados em bola de neve em redes sociais, entre junho e julho de 2020. Dados foram coletados em formulário eletrônico validado para este estudo. Resultados: Houve impacto negativo no acompanhamento de saúde e doenças cardiovasculares com perda de consultas e exames eletivos. Sintomas como dor torácica e crise hipertensiva foram negligenciados por medo de contágio, desconhecimento ou carência estrutural dos serviços, além do prejuízo no acompanhamento de condições crônicas. Conclusão: Nota-se gravidade nos resultados frente à evolução da COVID-19 e risco de complicações. É necessário organizar fluxos e estruturas compatíveis com cada perfil assistencial, nos serviços de saúde, para garantir atendimento e promover diagnóstico e controle de condições crônicas no conjunto de ações de contenção de pandemias. É determinante priorizar a atenção primária nos acompanhamentos de saúde em períodos pandêmicos, pois isso impacta diretamente na evolução dos quadros críticos dos demais níveis de atenção. Objetivo COVID19 COVID 19 COVID-1 Método descritivo transversal survey 79 adultos sociais 2020 estudo Resultados eletivos contágio Conclusão Notase Nota se complicações assistencial pandemias pandêmicos COVID1 1 COVID- 7 202 20 2

https://doi.org/10.1590/1980-220x-reeusp-2022-0112en

Excess weight in adolescents and associated factors: data from the ERICA study
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Lima, Niedja Maria da Silva

; Leal, Vanessa Sá

; Oliveira, Juliana Souza

; Andrade, Maria Izabel Siqueira de

; Santos, Natália Fernandes dos

; Pessoa, Jussara Tavares

; Aquino, Nathalia Barbosa de

; Lira, Pedro Israel Cabral de

Jornal de Pediatria

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dec 2021, Volume 97 N. 6 Pages 676 - 684

Abstract: En | Text: En | PDF: En

Abstract Objective: To estimate the prevalence of excessive weight and to identify associations with socioeconomic, demographic, biological, and lifestyle factors in adolescents. Methods: It is a cross-sectional school-based study, with a stratified and complex sample. The evaluated individuals were adolescents (2404), aged 12-17 years old, participating in the Study of Cardiovascular Risk Factors in Adolescents (ERICA). Demographic, socioeconomic, biological, anthropometric, and lifestyle variables were assessed. Poisson regression was used to verify the association between excess weight and independent variables. Results: The prevalence of excessive weight was 26.3% in the study population, being 16.3% for overweight and 10% for obesity. In the multivariate analysis (hierarchical model), were associated with excessive weight: private education network, a higher number of televisions in the residence, eating habits related to the breakfast consumption, snacks purchase in the canteen, snacks in front to screens consumption and consumption of carbohydrates and lipids, in addition to age group (12-14 years) and sexual maturation (post-pubertal). Conclusions: The prevalence of excessive weight among the school adolescents studied is high, with a value higher than the national average and the results of previous studies with adolescents. Its distribution is associated with different factors, which are socioeconomic, demographic, biological, and related to lifestyle, reinforcing the complexity of this condition, which deserves a broad coping approach, involving not only individual efforts but social and public ones as well.

https://doi.org/10.1016/j.jped.2021.02.008 1 downloads

Antibacterial, antifungal, and antiviral activities of chalcone-bearing tetrahydropyranyl and 2,4-dihydroxyl moieties
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Lima, William Gustavo

; Tauany Andrade, Jéssica

; Rocha da Silva Santos, Felipe

; Campos Palumbo, Juliana Maria

; Silva Herrera, Karina Marjorie

; de Castro, Laurieny Eloína

; de Morais, Fernanda Bárbara

; Prates da Silva, Mayra Karla

; Ferreira Perez Villar, José Augusto

; Siqueira Ferreira, Jaqueline Maria

Revista Colombiana de Ciencias Químico - Farmacéuticas

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apr 2020, Volume 49 N. 1 Pages 218 - 233

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

RESUMEN Las chalconas se destacan como una estructura importante en la química médica y, por lo tanto, se ha empleado como prototipo para el desarrollo de nuevos fármacos. En este estudio, nuestro objetivo fue determinar el potencial antibacteriano, anti Candida y anti-Dengue de las nuevas chalconas que poseen los grupos 2,4-dihidroxilo y tetrahidropiranilo. El ensayo de actividad antimicrobiana mostró que las bacterias del género Staphylococcus (incluidas las cepas resistentes a la meticilina) fueron sensibles a las 2,4-dihidroxicalconas estudiadas, con concentraciones inhibitorias mínimas (CIM) que oscilan entre 19,5 y 125 µg.mL-1. El compuesto 4e, que tuvo el mejor efecto bacteriostático, también mostró un efecto bactericida a partir de la concentración de 80 µg.mL-1. El crecimiento de los aislamientos orales de Candida albicans también se inhibió eficientemente con el compuesto 4e (CIM: 15.6-32.3 µg.mL-1), que fue fungicida a una concentración de 15.6 µg.mL-1. Sin embargo, la presencia del grupo tetrahidropiranilo perjudicó la actividad antibacteriana y anti-fúngica de los análogos de la chalcona. Además, ninguno de los compuestos evaluados mostró un efecto contra el virus del dengue serotipo 2. En conclusión, el compuesto 4e muestra una buena actividad anti-estafilocócica y anti-Candida y puede ser un prototipo prometedor para el desarrollo de nuevos agentes antimicrobianos.

SUMMARY Chalcones highlights as an important structure in medicinal chemistry and thus has been widely used as a template in the development of new drugs. In this study, we aim to determine the antibacterial, anti-Candida, and anti-Dengue potential of new chalcone-bearing 2,4-dihydroxyl and tetrahydropyranyl moieties. Antimicrobial activity assays showed that microorganism of the Staphylococcus genus (including methicillin-resistant strains) were susceptible to 2,4-dihydroxychalcones, with minimum inhibitory concentrations (MICs) ranging of 19.5 to 125 µg.mL-1. Compound 4e, which showed the highest bacteriostatic effect, also has bactericidal activity from of 80 µg.mL-1. The growth of oral isolates of Candida albicans was also efficiently inhibited with compound 4e (MIC: 15.6-32.3 µg.mL-1), which was fungicidal at 15.6 µg.mL-1. However, the presence of the tetrahydropyranyl moiety impaired both the antibacterial and antifungal effects. None of the chalcones tested were actives against Dengue virus serotype 2. In conclusion, the compound 4e showed good anti-Staphylococci and anti-Candida activity and may be a promising prototype for the development of new antimicrobial agents.

RESUMO As chalconas se destacam como uma importante estrutura na química medicinal e dessa forma tem sido empregada como um protótipo para o desenvolvimento de novos fármacos. Nesse estudo, nós objetivamos determinar o potencial antibacteriano, anti-Candida, e anti-Dengue de novas chalconas que possuem os grupos 2,4-dihidroxil e tetrahidropiranil. O ensaio de atividade antimicrobiana mostrou que bactérias do gênero Staphylococcus (incluindo linhagens resistentes a meticilina) foram sensíveis para as 2,4-dihidroxichalconas estudadas, com concentrações inibitórias mínimas (CIM) variando de 19,5 para 125 Dengue potential of new chalcone µg.mL-1. O composto 4e, o qual apresentou o melhor efeito bacteriostático, também mostrou efeito bactericida a partir da concentração de 80 µg.mL-1. O crescimento de isolados orais de Candida albicans foi também eficientemente inibido com o composto 4e (CIM: 15.6-32.3 µg.mL-1), o qual foi fungicida a concentração de 15,6 µg.mL-1. Entretanto, a presença do grupo tetrahidropiranil prejudicou a atividade antibacteriana e antifúngica dos análogos de chalcona. Adicionalmente, nenhum dos compostos avaliados mostrou efeito contra o vírus da dengue sorotipo 2. Em conclusão, o composto 4e apresenta boa atividade anti-estafilocóccica e anti-Candida, e pode ser um promissor protótipo para o desenvolvimento de novos agentes antimicrobianos.

https://doi.org/10.15446/rcciquifa.v49n1.87036 345 downloads

10.

Detection of Drug Resistant Mycobacterium Tuberculosis Strains Using Kit SIRE Nitratase®: a Multicenter Study
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Miranda, Silvana Spindola de

; Almeida, Isabela Neves de

; Mansur, Maria de Fátima Filardi Oliveira

; Figueredo, Lida Jouca de Assis

; Carvalho, Wânia da Silva

; Hadaad, João Paulo Amaral

; Diniz, Jaciara de Lourdes do Carmo Guimarães

; Groll, Andrea von

; Silva, Pedro Almeida da

; Lopes, Maria Luiza

; Santos, Marcelo Cordeiro dos

; Brito, Alexandra

; Mello, Fernanda Carvalho de Queiroz

; Malaquias, Thiago da Silva Santos

; Croda, Julio

; Pinhata, Juliana Maira Watanabe

; Oliveira, Rosângela Siqueira de

; Chimara, Erica

; Rossetti, Maria Lúcia

; Halon, Maria Laura

; Lourenço, Maria Cristina

; Medeiros, Reginalda Ferreira de Melo

; Montes, Fátima Cristina Onofre Fandinho

; Machado, Diana

; Viveiros, Miguel

; Kritski, Afrânio Lineu

Brazilian Archives of Biology and Technology

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2020, Volume 63 elocation e20190179

Abstract: En | Text: En | PDF: En

Abstract (1) Background: The Commercial Kit SIRE Nitratase® PlastLabor, is a drug susceptibility test kit used to detect Mycobacterium tuberculosis resistance to first-line TB treatment drugs. The present study aimed at evaluating its performance in a multicenter study. (2) Methods: To determine its accuracy, the proportion methods in Lowenstein Jensen medium or the BACTECTMMGITTM960 system was used as a gold standard. (3) Results: The study revealed that the respective accuracies of the kit with 190 M. tuberculosis clinical isolates, using the proportion methods in Lowenstein Jensen medium or BACTECTMMGITTM960 system as a gold standard, were 93.9% and 94.6%, 96.9% and 94.6%, 98.0% and 97.8%, and 98.0% and 98.9%, for streptomycin, isoniazid, rifampicin, and ethambutol, respectively. (4) Conclusion: Thus, the kit can rapidly screen resistance to streptomycin, isoniazid, rifampicin, and ethambutol. Additionally, it does not require sophisticated equipment; hence, it can be easily used in the laboratories of low and middle income countries.

https://doi.org/10.1590/1678-4324-2020190179 905 downloads

11.

The QualiRede intervention: improving the performance of care continuum in HIV, congenital syphilis, and hepatitis C in health regions
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Nemes, Maria Ines Battistella

; Castanheira, Elen Rose Lodeiro

; Alves, Ana Maroso

; Adania, Carolina Simone Souza

; Loch, Ana Paula

; Monroe, Aline Aparecida

; Souza, Rosa Alencar

; Gianna, Maria Clara

; Caminada, Sirlene

; Farias, Norma Suely de Oliveira

; Sousa, Paula de Oliveira e

; Domingues, Carmen Silva Bruniera

; Silva, Mariliza Henrique da

; Cervantes, Vilma

; Yamashiro, Juliana

; Caraciolo, Joselita Maria de Magalhães

; Silva, Fabiano Lima da

; Nemes Filho, Alexandre

; Jesus, Gabriel Lima de

; Helena, Ernani Tiaraju de Santa

; Albiero, José Francisco Gontan

; Lima, Marcela Soares Silveira

; Bellenzani, Renata

; Kehrig, Ruth Terezinha

; Vale, Felipe Campos do

; Nunes, Luceime Olivia

; Mendonça, Carolina Siqueira

; Zarili, Thais Fernanda Tortorelli

; Vilela, Mara Cristina

; Dantas, Jean Carlos de Oliveira

; Paula, Ivone de

; Tayra, Ângela

; Coelho, Débora Moraes

; Santos, Glauber Palha dos

; Quevedo, Dulce Castro

; Silva, Marcia Aparecida da

; Silva, Iraci Batista da

; Nasser, Mariana Arantes

; Andrade, Marta Campagnoni

; Santos, Maria Altenfelder

; Mercuri, Juliana

; Trindade, Katia Valeska

; Neves, Maria Aparecida Teixeira das

; Toledo, Renata Villanueva Alves de

; Almeida, Maria Cecília Rossi de

; Lima, Iraty Nunes

Revista Brasileira de Epidemiologia

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2019, Volume 22 Suppl. 1 elocation e190010

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: Modelos de cuidado contínuo baseiam recentes estratégias em HIV, infecções sexualmente transmissíveis e hepatite C (HCV). Métodos: Desenvolveram-se modelos de contínuo do cuidado em HIV, HCV e sífilis congênita incluindo todas as etapas da atenção, desde a promoção e a prevenção até o controle clínico/cura. O modelo baseou a intervenção QualiRede, desenvolvida em parceria entre universidade e Sistema Único de Saúde (SUS), direcionada a gestores e demais profissionais de 6 regiões de saúde prioritárias em São Paulo e Santa Catarina. Selecionaram-se indicadores para cada etapa do contínuo do cuidado, provenientes dos sistemas de informação do SUS e dos questionários de avaliação de processo Qualiaids e QualiAB. Os indicadores formaram a base técnica de duas oficinas com profissionais e gestores de cada região: a primeira para identificar problemas e formar um Grupo Técnico Regional; e a segunda para construir planos de ação e metas a fim de melhorar o desempenho regional. Resultados: Os indicadores estão disponíveis no website www.qualirede.org. As oficinas ocorreram em quatro regiões de São Paulo (Alto Tietê, Baixada Santista, Grande ABC e Registro) e uma região de Santa Catarina (Foz do Rio Itajaí), resultando em planos regionais em São Paulo, mas não em Santa Catarina. Observou-se domínio limitado dos novos protocolos para HIV e HCV e uso incipiente de indicadores na rotina dos serviços. Conclusão: Melhorar o desempenho do contínuo do cuidado exige apropriação dos indicadores de desempenho e coordenação integrada dos fluxos de atenção em todos os níveis de gestão.

ABSTRACT Introduction: Care continuum models have supported recent strategies against sexually transmitted diseases, such as HIV and Hepatitis C (HCV). Methods: HIV, HCV, and congenital syphilis care continuum models were developed, including all stages of care, from promotion/prevention to clinical control/cure. The models supported the intervention QualiRede, developed by a University-Brazilian National Health System (SUS) partnership focused on managers and other professionals from six priority health regions in São Paulo and Santa Catarina. Indicators were selected for each stage of the care continuum from the SUS information systems and from the Qualiaids and QualiAB facility’s process evaluation questionnaires. The indicators acted as the technical basis of two workshops with professionals and managers in each region: the first one to identify problems and to create a Regional Technical Group; and the second one to design action plans for improving regional performance. Results: The indicators are available at www.qualirede.org. The workshops took place in the regions of Alto Tietê, Baixada Santista, Grande ABC, and Registro (São Paulo) and of Foz do Rio Itajaí (Santa Catarina), which resulted in regional action plans in São Paulo, but not in Santa Catarina. A lack of awareness was observed regarding the new HIV and HCV protocols, as well as an incipient use of indicators in routine practices. Conclusion: Improving the performance of the care continuum requires appropriation of performance indicators and coordination of care flows at local, regional, and state levels of management.

https://doi.org/10.1590/1980-549720190010.supl.1 2475 downloads

12.

The QualiRede intervention: improving the performance of care continuum in HIV, congenital syphilis, and hepatitis C in health regions
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Nemes, Maria Ines Battistella

; Castanheira, Elen Rose Lodeiro

; Alves, Ana Maroso

; Adania, Carolina Simone Souza

; Loch, Ana Paula

; Monroe, Aline Aparecida

; Souza, Rosa Alencar

; Gianna, Maria Clara

; Caminada, Sirlene

; Farias, Norma Suely de Oliveira

; Sousa, Paula de Oliveira e

; Domingues, Carmen Silva Bruniera

; Silva, Mariliza Henrique da

; Cervantes, Vilma

; Yamashiro, Juliana

; Caraciolo, Joselita Maria de Magalhães

; Silva, Fabiano Lima da

; Nemes Filho, Alexandre

; Jesus, Gabriel Lima de

; Helena, Ernani Tiaraju de Santa

; Albiero, José Francisco Gontan

; Lima, Marcela Soares Silveira

; Bellenzani, Renata

; Kehrig, Ruth Terezinha

; Vale, Felipe Campos do

; Nunes, Luceime Olivia

; Mendonça, Carolina Siqueira

; Zarili, Thais Fernanda Tortorelli

; Vilela, Mara Cristina

; Dantas, Jean Carlos de Oliveira

; Paula, Ivone de

; Tayra, Ângela

; Coelho, Débora Moraes

; Santos, Glauber Palha dos

; Quevedo, Dulce Castro

; Silva, Marcia Aparecida da

; Silva, Iraci Batista da

; Nasser, Mariana Arantes

; Andrade, Marta Campagnoni

; Santos, Maria Altenfelder

; Mercuri, Juliana

; Trindade, Katia Valeska

; Neves, Maria Aparecida Teixeira das

; Toledo, Renata Villanueva Alves de

; Almeida, Maria Cecília Rossi de

; Lima, Iraty Nunes

Revista Brasileira de Epidemiologia

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2019, Volume 22 Suppl. 1 elocation e190010

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1980-549720190010.supl.1

13.

Assessment of neuropharmacological potential of low molecular weight components extracted from Rhinella schneideri toad poison
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Baldo, Mateus Amaral

; Cunha, Alexandra Olimpio Siqueira

; Godoy, Lívea Dornela

; Liberato, José Luiz

; Yoneda, Juliana Sakamoto

; Fornari-Baldo, Elisa Correa

; Ciancaglini, Pietro

; Santos, Wagner Ferreira dos

; Arantes, Eliane Candiani

Journal of Venomous Animals and Toxins including Tropical Diseases

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2019, Volume 25 elocation e148418

Abstract: En | Text: En | PDF: En

Abstract Background: Studies on toad poison are relevant since they are considered a good source of toxins that act on different biological systems. Among the molecules found in the toad poison, it can be highlighted the cardiotonic heterosides, which have a known mechanism that inhibit Na+/K+-ATPase enzyme. However, these poisons have many other molecules that may have important biological actions. Therefore, this work evaluated the action of the low molecular weight components from Rhinella schneideri toad poison on Na+/K+-ATPase and their anticonvulsive and / or neurotoxic effects, in order to detect molecules with actions of biotechnological interest. Methods: Rhinella schneideri toad (male and female) poison was collected by pressuring their parotoid glands and immediately dried and stored at -20 °C. The poison was dialysed and the water containing the low molecular mass molecules (< 8 kDa) that permeate the dialysis membrane was collected, frozen and lyophilized, resulting in the sample used in the assays, named low molecular weight fraction (LMWF). Na+/K+ ATPase was isolated from rabbit kidneys and enzyme activity assays performed by the quantification of phosphate released due to enzyme activity in the presence of LMWF (1.0; 10; 50 and 100 µg/mL) from Rhinella schneideri poison. Evaluation of the L-Glutamate (L-Glu) excitatory amino acid uptake in brain-cortical synaptosomes of Wistar rats was performed using [3H]L-glutamate and different concentration of LMWF (10-5 to 10 µg/µL). Anticonvulsant assays were performed using pentylenetetrazole (PTZ) and N-methyl-D-aspartate (NMDA) to induce seizures in Wistar rats (n= 6), which were cannulated in the lateral ventricle and treated with different concentration of LMWF (0.25; 0.5; 1.0; 2.0; 3.0 and 4.0 µg/µL) 15 min prior to the injection of the seizure agent. Results: LMWF induced a concentration-dependent inhibition of Na+/K+-ATPase (IC50% = 107.5 μg/mL). The poison induces an increased uptake of the amino acid L-glutamate in brain-cortical synaptosomes of Wistar rats. This increase in the L-glutamate uptake was observed mainly at the lowest concentrations tested (10-5 to 10-2 µg/µL). In addition, this fraction showed a very relevant central neuroprotection on seizures induced by PTZ and NMDA. Conclusions: LMWF from Rhinella schneideri poison has low molecular weight compounds, which were able to inhibit Na+/K+-ATPase activity, increase the L-glutamate uptake and reduced seizures induced by PTZ and NMDA. These results showed that LMWF is a rich source of components with biological functions of high medical and scientific interest.

https://doi.org/10.1590/1678-9199-jvatitd-1484-18 1080 downloads

14.

Performance of the IS6110-TaqMan® assay in the diagnosis of extrapulmonary tuberculosis from different biological samples
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Santos, Fabiana Cristina Fulco

; Lira, Laís Ariane de Siqueira

; Montenegro, Rosana de Albuquerque

; Lima, Juliana Figueirêdo da Costa

; Lima, Andrea Santos

; Schindler, Haiana Charifker

; Montenegro, Lílian Maria Lapa

Revista da Sociedade Brasileira de Medicina Tropical

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jun 2018, Volume 51 N. 3 Pages 331 - 337

Abstract: En | Text: En | PDF: En

Abstract INTRODUCTION: This study evaluated the performance of the IS6110-TaqMan® assay in different types of biological samples and tissues for laboratory diagnosis of extrapulmonary tuberculosis. METHODS: 143 biological samples and tissues from patients with suspected extrapulmonary tuberculosis from the health services of Recife/Pernambuco/Brazil were evaluated with the IS6110-TaqMan® assay. RESULTS: The sensitivities of the IS6110-TaqMan® assay calculated for blood, urine, both blood and urine samples, tissue biopsies, extrapulmonary body fluid samples, and all samples from patients calculated together were 55.9%, 33.3%, 68.8%, 43.8%, 29.6%, and 73.7%, respectively, and the specificities were 80%, 100%, 78.6%, 100%, 100%, and 84.2%, respectively. CONCLUSIONS The accuracy of qPCR was high in various clinical sample types. The analysis of more than one type of clinical sample collected from the same patient with extrapulmonary tuberculosis enhances the diagnostic power of the IS6110-TaqMan® assay when compared with the use of only one clinical sample.

https://doi.org/10.1590/0037-8682-0372-2017 1265 downloads

15.

LAPAROSCOPIC ABDOMINOPERINEAL RESECTION WITH SACRECTOMY: TECHNICAL DETAILS AND PITFALLS
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IGREJA-JUNIOR, Haroldo Jose Siqueira

; BATISTA, Vilson Leite

; CARVALHO, Bruno dos Santos Viana

; TAVARES, Lucas Simões

; COELHO, Juliana Gonçalves

ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)

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dec 2017, Volume 30 N. 4 Pages 290 - 291

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/0102-6720201700040016 2085 downloads

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