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RESUMO Contexto: Em estudos observacionais sobre a síndrome do desconforto respiratório agudo, sugeriu-se que a driving pressure é o principal fator de lesão pulmonar induzida por ventilador e de mortalidade. Não está claro se uma estratégia de limitação da driving pressure pode melhorar os desfechos clínicos. Objetivo: Descrever o protocolo e o plano de análise estatística que serão usados para testar se uma estratégia de limitação da driving pressure envolvendo a titulação da pressão positiva expiratória final de acordo com a melhor complacência respiratória e a redução do volume corrente é superior a uma estratégia padrão envolvendo o uso da tabela de pressão positiva expiratória final baixa do protocolo ARDSNet, em termos de aumento do número de dias sem ventilador em pacientes com síndrome do desconforto respiratório agudo devido à pneumonia adquirida na comunidade. Métodos: O estudo STAMINA (ventilator STrAtegy for coMmunIty acquired pNeumoniA) é randomizado, multicêntrico e aberto e compara uma estratégia de limitação da driving pressure com a tabela de pressão positiva expiratória final baixa do protocolo ARDSnet em pacientes com síndrome do desconforto respiratório agudo moderada a grave devido à pneumonia adquirida na comunidade internados em unidades de terapia intensiva. Esperamos recrutar 500 pacientes de 20 unidades de terapia intensiva brasileiras e duas colombianas. Eles serão randomizados para um grupo da estratégia de limitação da driving pressure ou para um grupo de estratégia padrão usando a tabela de pressão positiva expiratória final baixa do protocolo ARDSnet. No grupo da estratégia de limitação da driving pressure, a pressão positiva expiratória final será titulada de acordo com a melhor complacência do sistema respiratório. Desfechos: O desfecho primário é o número de dias sem ventilador em 28 dias. Os desfechos secundários são a mortalidade hospitalar e na unidade de terapia intensiva e a necessidade de terapias de resgate, como suporte de vida extracorpóreo, manobras de recrutamento e óxido nítrico inalado. Conclusão: O STAMINA foi projetado para fornecer evidências sobre se uma estratégia de limitação da driving pressure é superior à estratégia da tabela de pressão positiva expiratória final baixa do protocolo ARDSnet para aumentar o número de dias sem ventilador em 28 dias em pacientes com síndrome do desconforto respiratório agudo moderada a grave. Aqui, descrevemos a justificativa, o desenho e o status do estudo. Contexto sugeriuse sugeriu clínicos Objetivo ARDSNet Métodos ventilator pNeumoniA randomizado 50 2 colombianas Desfechos resgate extracorpóreo inalado Conclusão Aqui justificativa 5

ABSTRACT Background: Driving pressure has been suggested to be the main driver of ventilator-induced lung injury and mortality in observational studies of acute respiratory distress syndrome. Whether a driving pressure-limiting strategy can improve clinical outcomes is unclear. Objective: To describe the protocol and statistical analysis plan that will be used to test whether a driving pressure-limiting strategy including positive end-expiratory pressure titration according to the best respiratory compliance and reduction in tidal volume is superior to a standard strategy involving the use of the ARDSNet low-positive end-expiratory pressure table in terms of increasing the number of ventilator-free days in patients with acute respiratory distress syndrome due to community-acquired pneumonia. Methods: The ventilator STrAtegy for coMmunIty acquired pNeumoniA (STAMINA) study is a randomized, multicenter, open-label trial that compares a driving pressure-limiting strategy to the ARDSnet low-positive end-expiratory pressure table in patients with moderate-to-severe acute respiratory distress syndrome due to community-acquired pneumonia admitted to intensive care units. We expect to recruit 500 patients from 20 Brazilian and 2 Colombian intensive care units. They will be randomized to a driving pressure-limiting strategy group or to a standard strategy using the ARDSNet low-positive end-expiratory pressure table. In the driving pressure-limiting strategy group, positive end-expiratory pressure will be titrated according to the best respiratory system compliance. Outcomes: The primary outcome is the number of ventilator-free days within 28 days. The secondary outcomes are in-hospital and intensive care unit mortality and the need for rescue therapies such as extracorporeal life support, recruitment maneuvers and inhaled nitric oxide. Conclusion: STAMINA is designed to provide evidence on whether a driving pressure-limiting strategy is superior to the ARDSNet low-positive end-expiratory pressure table strategy for increasing the number of ventilator-free days within 28 days in patients with moderate-to-severe acute respiratory distress syndrome. Here, we describe the rationale, design and status of the trial. Background ventilatorinduced induced pressurelimiting limiting unclear Objective endexpiratory end expiratory lowpositive low ventilatorfree free communityacquired community Methods (STAMINA multicenter openlabel open label moderatetosevere moderate severe units 50 Outcomes inhospital hospital support oxide Conclusion Here rationale 5

https://doi.org/10.62675/2965-2774.20240210-en

Sleep quality and falls in middle-aged and older adults: ELSI-Brazil study middleaged middle aged adults ELSIBrazil ELSI Brazil
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Santos, André Pereira dos

; Cordeiro, Jéssica Fernanda Correa

; Abdalla, Pedro Pugliesi

; Bohn, Lucimere

; Sebastião, Emerson

; Silva, Leonardo Santos Lopes da

; Tasinafo Júnior, Márcio Fernando

; Venturini, Ana Cláudia Rossini

; Andaki, Alynne Christian Ribeiro

; Mendes, Edmar Lacerda

; Marcos-Pardo, Pablo Jorge

; Mota, Jorge

; Machado, Dalmo Roberto Lopes

Revista da Escola de Enfermagem da USP

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2024, Volume 58 elocation e20240027

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo: Verificar a associação entre baixa qualidade do sono autorrelatada (BQS) e quedas em adultos de meia-idade e idosos a cada meia década de vida. Método: Um estudo transversal foi conduzido utilizando dados da primeira onda (2015–2016) do Estudo Longitudinal Brasileiro do Envelhecimento (ELSI-Brasil), que é nacionalmente representativo. A população consistiu em 8.950 participantes que foram alocados em oito grupos etários: 50–54, 55–59, 60–64, 65–69, 70–74, 75–79, 80–84 e ≥ 85 anos. Os questionários utilizados incluíram qualidade do sono autorrelatada e o Questionário Internacional de Atividade Física versão curta. O teste exato de Fisher seguido pela análise de regressão logística binária foi conduzida para identificar a razão de chances da BQS para ocorrência de queda, controlando por variáveis de confusão. Resultados: Pessoas com idades entre 50 e 105 anos (63,6 ± 10,2 anos), sendo 57,0% do sexo feminino e 43,0% do sexo masculino, participaram deste estudo. No geral, 21,5% dos participantes experimentaram pelo menos uma queda. A frequência relativa de participantes classificados como tendo BQS ou alta permaneceu constante em cada meia década de vida. A BQS exibiu uma OR (p < 0,05) notável para quedas em grupos etários até 84 anos, mesmo após o ajuste para variáveis de confusão. Conclusão: A BQS está significativamente associada a uma maior ocorrência de queda em adultos com mais de 50 anos, mas não para ≥ 85 anos, independentemente do sexo e do nível de atividade física. Objetivo (BQS meiaidade idade vida Método 2015–2016 20152016 2015 2016 (2015–2016 ELSIBrasil, ELSIBrasil ELSI Brasil , (ELSI-Brasil) representativo 8950 8 950 8.95 5054 54 50–54 5559 55 59 55–59 6064 60 64 60–64 6569 65 69 65–69 7074 70 74 70–74 7579 75 79 75–79 8084 80 80–8 curta confusão Resultados 5 10 63,6 636 63 6 (63, 102 2 10, anos) 570 57 0 57,0 430 43 43,0 masculino geral 215 21 21,5 p 0,05 005 05 Conclusão física 2015–201 2015201 201 (2015–201 (ELSI-Brasil 895 95 8.9 505 50–5 555 55–5 606 60–6 656 65–6 707 7 70–7 757 75–7 808 80– 1 63, (63 57, 4 43, 21, 0,0 00 2015–20 201520 20 (2015–20 89 9 8. 50– 55– 60– 65– 70– 75– (6 0, 2015–2 20152 (2015–2 ( 2015– (2015– (2015 (201 (20 (2

ABSTRACT Objective: To verify the association between low self-reported sleep quality (LSQ) and fall in middle-aged and older adults every half-decade of life. Method: A cross-sectional study was conducted using data from the first wave (2015–2016) of the Brazilian Longitudinal Study of Aging (ELSI-Brazil), which is nationally representative. The sample consisted of 8,950 participants who were allocated into eight age groups: 50–54, 55–59, 60–64, 65–69, 70–74, 75–79, 80–84, and ≥ 85 years. The questionnaires used included self-reported sleep quality and the International Physical Activity Questionnaire short version. Fisher’s exact test followed by binary logistic regression analysis was performed to identify the odds ratio of sleep quality for fall occurrence, controlled for confounding variables. Results: Individuals aged 50–105 years (63.6 ± 10.2 years), 57.0% females and 43.0% males, participated in this study. Overall, 21.5% of participants experienced at least one fall. The relative frequency of participants classified as having high or LSQ remained constant across each half-decade of life. The LSQ exhibited a statistically significant OR (p < 0.05) for falls across age groups up to 84, even after accounting for confounding variables. Conclusion: LSQ is significantly associated with an increased occurrence of fall in adults aged >50 years, but not for ≥ 85 years regardless of sex and physical activity level. Objective selfreported self reported (LSQ middleaged middle halfdecade half decade life Method crosssectional cross sectional 2015–2016 20152016 2015 2016 (2015–2016 ELSIBrazil, ELSIBrazil ELSI Brazil , (ELSI-Brazil) representative 8950 8 950 8,95 5054 50 54 50–54 5559 55 59 55–59 6064 60 64 60–64 6569 65 69 65–69 7074 70 74 70–74 7579 75 79 75–79 8084 80 84 80–84 version Fishers Fisher s variables Results 50105 105 50–10 63.6 636 63 6 (63. 102 10 2 10. years) 570 57 0 57.0 430 43 43.0 males Overall 215 21 5 21.5 p 0.05 005 05 Conclusion >5 level 2015–201 2015201 201 (2015–201 (ELSI-Brazil 895 95 8,9 505 50–5 555 55–5 606 60–6 656 65–6 707 7 70–7 757 75–7 808 80–8 5010 50–1 63. (63 1 57. 4 43. 21. 0.0 00 > 2015–20 201520 20 (2015–20 89 9 8, 50– 55– 60– 65– 70– 75– 80– 501 (6 0. 2015–2 20152 (2015–2 ( 2015– (2015– (2015 (201 (20 (2

RESUMEN Objetivo: Verificar la asociación entre la baja calidad del sueño autorreportada (BCS) y las caídas en adultos de mediana edad y mayores cada media década de vida. Método: Se realizó un estudio transversal utilizando datos de la primera oleada (2015–2016) del Estudio Longitudinal Brasileño sobre el Envejecimiento (ELSI-Brasil), que es representativo a nivel nacional. La muestra consistió en 8,950 participantes que fueron asignados a ocho grupos de edad: 50–54, 55–59, 60–64, 65–69, 70–74, 75–79, 80–84 y ≥ 85 años. Los cuestionarios utilizados incluyeron calidad del sueño autorreportada y el Cuestionario Internacional de Actividad Física versión corta. Se realizó una prueba exacta de Fisher seguida por un análisis de regresión logística binaria para identificar la razón de probabilidades de la calidad del sueño para la ocurrencia de caídas, controlando las variables de confusión. Resultados: Participaron en este estudio individuos con edades entre 50 y 105 años (63,6 ± 10,2 años), siendo el 57,0% mujeres y el 43,0% hombres. En general, el 21,5% de los participantes experimentaron al menos una caída. La frecuencia relativa de participantes clasificados como con alta calidad de sueño o baja calidad de sueño (BCS) se mantuvo constante a lo largo de cada media década de vida. La BCS mostró un OR (p < 0,05) notable para las caídas en grupos de edad hasta los 84 años, incluso después de ajustar por variables de confusión. Conclusión: La BCS está significativamente asociada con una mayor ocurrencia de caídas en adultos mayores de 50 años, pero no para ≥ 85 años, independientemente del sexo y del nivel de actividad física. Objetivo (BCS vida Método 2015–2016 20152016 2015 2016 (2015–2016 ELSIBrasil, ELSIBrasil ELSI Brasil , (ELSI-Brasil) nacional 8950 8 950 8,95 5054 54 50–54 5559 55 59 55–59 6064 60 64 60–64 6569 65 69 65–69 7074 70 74 70–74 7579 75 79 75–79 8084 80 80–8 corta confusión Resultados 5 10 63,6 636 63 6 (63, 102 2 10, años) 570 57 0 57,0 430 43 43,0 hombres general 215 21 21,5 caída p 0,05 005 05 Conclusión física 2015–201 2015201 201 (2015–201 (ELSI-Brasil 895 95 8,9 505 50–5 555 55–5 606 60–6 656 65–6 707 7 70–7 757 75–7 808 80– 1 63, (63 57, 4 43, 21, 0,0 00 2015–20 201520 20 (2015–20 89 9 8, 50– 55– 60– 65– 70– 75– (6 0, 2015–2 20152 (2015–2 ( 2015– (2015– (2015 (201 (20 (2

https://doi.org/10.1590/1980-220x-reeusp-2024-0027en

Ischemic Stroke and Acute Myocardial Infarction: Trends in in-Hospital Mortality in Brazil from 1998 to 2018 Infarction inHospital Hospital 199 201 19 20 1 2
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Santos, Júlio Martinez

; Martinez, Alessandra Barboza Resende

; Silva, Emerson de Jesus

; Santana, Gustavo Roberto

; Barbosa, Romero Henrique de Almeida

; Lima, David Fernandes

; Lopes, Matheus Rodrigues

; Lopes, Johnnatas Mikael

International Journal of Cardiovascular Sciences

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2023, Volume 36 elocation e20220217

Abstract: En | Text: En | PDF: En

Abstract Background Ischemic stroke and acute myocardial infarction (AMI) are cardiovascular diseases with high morbidity and mortality rates in Brazil and worldwide. Their outcomes are influenced by public policies aimed at mitigating risk factors and by investments in infrastructure of emergency support and quality of hospital care. Objective To analyze the trend in the proportion of in-hospital deaths from ischemic stroke and AMI in Brazil as a way of evaluating the effectiveness of urgency and emergency services. Methods Ecological time series study using data from the Hospital Information System. The outcome was the proportion of in-hospital deaths from ischemic stroke and AMI with stratification by sex and state. Prais-Winsten regression was used to analyze the trend between 1998-2018 with α≤0,05. Results The proportion of deaths from AMI and ischemic stroke declined in the time series (p<0.001), decreasing annually by 0.17% and 0.25%, respectively. In 20 years, it reduced 43.76% (ischemic stroke) and 32.39% (AMI) in both sexes. However, the decline was more evident in the South and Southeast regions. Conclusion The reduction in hospital deaths from AMI and ischemic stroke was heterogeneous among Brazilian regions, which may be related to inequality in emergency services and hospital support. (AMI worldwide care inhospital System state PraisWinsten Prais Winsten 19982018 1998 2018 1998-201 α005 α 0 05 α≤0,05 p<0.001, p0001 p p<0.001 , 001 (p<0.001) 017 17 0.17 025 25 0.25% respectively 2 years 4376 43 76 43.76 3239 32 39 32.39 sexes However regions 1998201 199 201 1998-20 α00 α≤0,0 p000 p<0.00 00 (p<0.001 01 1 0.1 02 0.25 437 4 7 43.7 323 3 32.3 199820 19 1998-2 α0 α≤0, p00 p<0.0 (p<0.00 0. 0.2 43. 32. 19982 1998- α≤0 p0 p<0. (p<0.0 α≤ p<0 (p<0. p< (p<0 (p< (p

https://doi.org/10.36660/ijcs.20220217

Four Brazilian Potential Species Almost Unexplored of Connaraceae Family Used Popularly for Diabetes: Chemical Composition and in vitro Activity Diabetes
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Paim, Luís Fernando N. A.

; Acho, Leonard D. R.

; Santos, Paulo Roberto dos

; Toledo, Cássio Augusto P.

; Minello, Luana

; Paz, Joicelene Regina L. da

; Lima, Emerson

; Salvador, Mirian

; Moura, Sidnei

Journal of the Brazilian Chemical Society

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2023, Volume 34 N. 12 Pages 1773 - 1787

Abstract: En | Text: En | PDF: En

Connaraceae is a plant family usually used in traditional medicine. Recently, we have reported the chemical composition and biological activity of 39 species around the world. This work highlights the application of these species to diabetes control, which has been reported at least to half of this family. In this line, there are several species of the Connaraceae without scientific evidence of traditional use, among these the four species study here. Thus, this work aims the chemical composition prospection of Connarus blanchetii, Connarus regnellii, Connarus suberosus and Rourea glazioui, as well as the identification of possible bioactivity. The leaves of these four species were collected, prepared and submitted to different extractive methods (aqueous decoction and infusion and ethanolic maceration), these being tested in a preliminary phytochemical investigation and subjected to antioxidant assay with 2,2-diphenyl-1-picrylhydrazyl and ferric reducing antioxidant power. Then, we selected the maceration extract to continue for fractions, with the ethyl acetate and n-butanol presenting the best results with antioxidant and anti-advanced glycation end products (AGEs) activity potential. Finally, the chemical composition was determinate by high-resolution mass spectrometry (HRMS) in combination with Global Natural Products Service (GNPS) data bank. As a result, this study indicated the presence of 29 phenolics compounds with reported activity as antioxidant and with potential of protein glycation, supported the diabetes activity of this plants. The n-butanolic fraction of R. glazioui showed compounds such as apigenin, kaempferol, quercetin, myricetin and chlorogenic acid, which have generated a half maximal inhibitory concentration (IC50) of 36.5 µg mL 1 for oxidative glycation inhibition, being highlighted as the most active. medicine Recently 3 world control line use here Thus blanchetii regnellii bioactivity collected aqueous maceration, , maceration) 2,2diphenyl1picrylhydrazyl 22diphenyl1picrylhydrazyl diphenylpicrylhydrazyl 2,2 diphenyl picrylhydrazyl 2 power Then fractions nbutanol n butanol antiadvanced anti advanced AGEs (AGEs Finally highresolution high resolution HRMS (HRMS GNPS (GNPS bank result plants nbutanolic butanolic R apigenin kaempferol quercetin acid IC50 IC (IC50 365 36 5 36. inhibition active 2diphenyl1picrylhydrazyl 22 2, IC5 (IC5 (IC

https://doi.org/10.21577/0103-5053.20230070

Stroke and Myocardial Infarction: Effects of the “Hiperdia” and “Mais Médicos” Programs on the Hospitalizations Trends in Brazil
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Santos, Júlio Martinez

; Martinez, Alessandra Barboza Resende

; Silva, Emerson de Jesus

; Souza, Gustavo Roberto Santana

; Lopes, Johnnatas Mikael

International Journal of Cardiovascular Sciences

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nov 2021, Volume 34 N. 5 Pages 44 - 52

Abstract: En | Text: En | PDF: En

Abstract Background Stroke and acute myocardial infarction (AMI) are cardiovascular diseases commonly characterized by the development of atheromatous plaques associated with major complications and high mortality rates. Objective To identify an epidemiological trend in hospitalizations due to stroke and AMI and to analyze the relationship between health programs applied in Primary Health Care, gender and the Federative Unit. Methods Ecological study with a time series design between 1998 and 2018, collecting data from all federal units in Brazil stratified by, gender and place of residence. There were analyzed Hospitalization Authorizations (AIH) for stroke and MI, consulting the Hospital Admissions System (SIH) of the Informatics Department of the National Health Service with p <0.05. Results From 1998 to 2018, the rate of hospitalization for AMI increased in Brazil approximately 42.58 events per 100 thousand inhabitants annually (p<0.001), while hospitalizations for stroke declined 32.17 cases (p=0.03). This pattern was observed in both sexes in AMI and stroke. There is also evidence of the effect of the Hiperdia (p<0.001) and Mais Médicos (p=0.001) program in reducing stroke and Hiperdia cases in mitigating the evolution of AMI cases (p = 0.0001). Conclusion Although these diseases remain as an important cause of death, stroke hospitalization has reduced significantly in the period evaluated. National programs as the Hiperdia and Mais Médicos showed an impact in the acute cases of strokes and AMI.

https://doi.org/10.36660/ijcs.20200270 58 downloads

COVID-19: The question of genetic diversity and therapeutic intervention approaches
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Figueiredo, David Livingstone Alves

; Ximenez, João Paulo Bianchi

; Seiva, Fábio Rodrigues Ferreira

; Panis, Carolina

; Bezerra, Rafael dos Santos

; Ferrasa, Adriano

; Cecchini, Alessandra Lourenço

; Medeiros, Alexandra Ivo de

; Almeida, Ana Marisa Fusco

; Ramão, Anelisa

; Boldt, Angelica Beate Winter

; Moya, Carla Fredrichsen

; Chin, Chung Man

; Paula, Daniel de

; Rech, Daniel

; Gradia, Daniela Fiori

; Malheiros, Danielle

; Venturini, Danielle

; Tavares, Eliandro Reis

; Carraro, Emerson

; Ribeiro, Enilze Maria de Souza Fonseca

; Pereira, Evani Marques

; Tuon, Felipe Francisco

; Follador, Franciele Aní Caovilla

; Fernandes, Glaura Scantamburlo Alves

; Volpato, Hélito

; Cólus, Ilce Mara de Syllos

; Oliveira, Jaqueline Carvalho de

; Rodrigues, Jean Henrique da Silva

; Santos, Jean Leandro dos

; Visentainer, Jeane Eliete Laguila

; Brandi, Juliana Cristina

; Serpeloni, Juliana Mara

; Bonini, Juliana Sartori

; Oliveira, Karen Brajão de

; Fiorentin, Karine

; Lucio, Léia Carolina

; Faccin-Galhardi, Ligia Carla

; Ferreto, Lirane Elize Defante

; Lioni, Lucy Megumi Yamauchi

; Consolaro, Marcia Edilaine Lopes

; Vicari, Marcelo Ricardo

; Arbex, Marcos Abdo

; Pileggi, Marcos

; Watanabe, Maria Angelica Ehara

; Costa, Maria Antônia Ramos

; Giannini, Maria José S. Mendes

; Amarante, Marla Karine

; Khalil, Najeh Maissar

; Lima Neto, Quirino Alves de

; Herai, Roberto H.

; Guembarovski, Roberta Losi

; Shinsato, Rogério N.

; Mainardes, Rubiana Mara

; Giuliatti, Silvana

; Yamada-Ogatta, Sueli Fumie

; Gerber, Viviane Knuppel de Quadros

; Pavanelli, Wander Rogério

; Silva, Weber Claudio da

; Petzl-Erler, Maria Luiza

; Valente, Valeria

; Soares, Christiane Pienna

; Cavalli, Luciane Regina

; Silva Jr, Wilson Araujo

Genetics and Molecular Biology

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2021, Volume 44 N. 1 elocation e20200452

Abstract: En | Text: En | PDF: En

Abstract Coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2), is the largest pandemic in modern history with very high infection rates and considerable mortality. The disease, which emerged in China’s Wuhan province, had its first reported case on December 29, 2019, and spread rapidly worldwide. On March 11, 2020, the World Health Organization (WHO) declared the COVID-19 outbreak a pandemic and global health emergency. Since the outbreak, efforts to develop COVID-19 vaccines, engineer new drugs, and evaluate existing ones for drug repurposing have been intensively undertaken to find ways to control this pandemic. COVID-19 therapeutic strategies aim to impair molecular pathways involved in the virus entrance and replication or interfere in the patients’ overreaction and immunopathology. Moreover, nanotechnology could be an approach to boost the activity of new drugs. Several COVID-19 vaccine candidates have received emergency-use or full authorization in one or more countries, and others are being developed and tested. This review assesses the different strategies currently proposed to control COVID-19 and the issues or limitations imposed on some approaches by the human and viral genetic variability.

https://doi.org/10.1590/1678-4685-gmb-2020-0452

[SciELO Preprints] - Resilience as a protective factor to minor mental disorders in the nursing team
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Santos, Emerson Roberto dos Bertolin, Daniela Comelis Pompeo, Daniele Alcalá Alves, Isadora Gama Roque, Cleber José Fucuta, Patrícia da Silva André, Júlio César

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Publication date: 2020-11-13

Abstract: En Es Pt

OBJECTIVES: To track the presence of minor mental disorders and levels of resilience in nursing professionals who work in emergency services and inpatient units, as well as to verify possible associations between these variables and sociodemographic and professional characteristics. METHODS: Descriptive, correlational and cross-sectional study consisted of 203 nursing professionals (nurses, nursing technicians, and nursing assistants), from the country side of São Paulo State. Data collection was performed using a sociodemographic and professional characterization instrument and the Brazilian version of the Self-Report Questionnaire (SRQ-20) and the resilience scale. RESULTS: The overall prevalence of minor mental disorders among the participants was 31%, being lower among older professionals and men. The resilience of the professionals was high, with mean values of 136.4 (±20.1) points. Older professionals and those who worked in emergency units had higher resilience scores. Lower resilience scores are associated with a greater possibility of minor mental disorders in this study. CONCLUSION: Resilience can be considered a protective factor against minor mental disorders in nursing professionals. Effective strategies must be taken into account to change this scenario of illness of a significant part of the nursing team.

OBJETIVOS: Realizar un seguimiento de la presencia de trastornos mentales menores, evaluar los niveles de resiliencia de los profesionales de enfermería de los servicios de urgencias y unidades de internación y comprobar las posibles asociaciones entre estas variables y el perfil sociodemográfico y profesional. MÉTODOS: Estudio descriptivo, correlacional y transversal. Participaron 203 profesionales de enfermería (enfermeros, técnicos y auxiliares de enfermería), del interior del estado de São Paulo. La recolección de datos se realizó mediante una herramienta de caracterización sociodemográfica y profesional, el Cuestionario de Autoinforme (SRQ-20) y la escala de resiliencia. RESULTADOS: Prevalencia global de trastornos mentales menor al 31%, menor en profesionales mayores y varones. Alta resiliencia, con valores medios de 136,4 (±20,1) puntos. La edad avanzada y el desempeño en las unidades de emergencia obtuvieron puntajes de resiliencia más altos. Los puntajes de resiliencia más bajos se asocian con una mayor posibilidad de trastornos mentales menores en este estudio. CONCLUSIÓN: La resiliencia puede considerarse un factor protector frente a los trastornos mentales menores en los profesionales de enfermería. Se deben tener en cuenta estrategias efectivas para cambiar este escenario de enfermedad de una parte significativa del equipo de enfermería.

OBJETIVOS: Rastrear a presença de transtornos mentais menores, avaliar os níveis de resiliência em profissionais de enfermagem de serviços de emergência e unidades de internação e verificar possíveis associações entre essas variáveis e o perfil sociodemográfico e profissional. MATERIAL E MÉTODO: Estudo descritivo, correlacional e transversal. Participaram 203 profissionais de enfermagem (enfermeiros, técnicos e auxiliares de enfermagem), do interior do estado de São Paulo. A coleta dos dados foi realizada por meio de instrumento de caracterização sociodemográfica e profissional, o Self-Report Questionnaire (SRQ-20), e da escala de resiliência. RESULTADOS: Prevalência global dos transtornos mentais menores de 31%, menor em profissionais de maior idade e do sexo masculino. Resiliência elevada, com valores médios de 136,4 (±20,1) pontos. Maior idade e atuação em unidades de emergência obtiveram escores mais elevados de resiliência. Menores escores de resiliência estiveram associados a maior possibilidade de transtornos mentais menores neste estudo. CONCLUSÕES: Resiliência pode ser considerada fator de proteção contra os transtornos mentais menores em profissionais de enfermagem. Estratégias efetivas devem ser levadas em conta para mudar esse cenário de adoecimento de parte significativa da equipe de enfermagem.

https://doi.org/10.1590/SciELOPreprints.1467

REPLY TO REVIEW IN “HEMODYNAMIC RESPONSE AFTER CONCURRENT CROSS EXERCISE IN HYPERTENSIVE WOMEN”
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Wanderley, Erik de Cerqueira

; Souza, Alice Conrado de

; Santos, Laiza Ellen Santana

; Pacheco, Alexandra de França

; Costa, Pedro Danilo Paiva

; Santos, Roberto Emmanuel Nascimento

; Novais, Lucas Santos

; Wichi, Rogerio Brandão

; Pardono, Emerson

Revista Brasileira de Medicina do Esporte

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aug 2020, Volume 26 N. 4 Pages 280 - 280

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/1517-869220202604000011 257 downloads

HEMODYNAMIC RESPONSE AFTER CONCURRENT CROSS EXERCISE IN HYPERTENSIVE WOMEN
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Wanderley, Erik de Cerqueira

; Souza, Alice Conrado de

; Santos, Laiza Ellen Santana

; Pacheco, Alexandra de França

; Costa, Pedro Danilo Paiva

; Santos, Roberto Emmanuel Nascimento

; Novais, Lucas Santos

; Wichi, Rogerio Brandão

; Pardono, Emerson

Revista Brasileira de Medicina do Esporte

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apr 2020, Volume 26 N. 2 Pages 122 - 125

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Introdução: A hipertensão arterial sistêmica é uma doença que acomete, principalmente, mulheres. Objetivo: O presente estudo teve como objetivo verificar o efeito hipotensor e a reatividade da pressão arterial em mulheres submetidas a uma sessão de exercício concorrente cruzado (CC). Métodos: Quinze voluntárias (54±3) realizaram exercício aeróbico alternado com uma série de exercícios com peso para a análise da variação da pressão arterial (através do método oscilométrico) e reatividade pressórica (através do Cold pressure test) pré- e pós-exercício. Resultados: Os resultados demonstraram a ocorrência da hipotensão pós-exercício na fase sistólica na comparação entre CC e C pós- exercício (−11,65mmHg). O CC provocou a atenuação de 7 mmHg e 4 mmHg para PAS e PAD, respectivamente, na reatividade pressórica após uma sessão. Conclusão: Conclui-se que o exercício concorrente cruzado garante hipotensão e reatividade positiva da pressão arterial sistólica. Nível de evidência II; Estudos terapêuticos–Investigação dos resultados do tratamento.

ABSTRACT Introduction: Systemic arterial hypertension is a disease that mainly affects women. Objective: This study aimed to verify the hypotensive effect and blood pressure reactivity in women submitted to a concurrent cross exercise (CC) session. Methods: Fifteen volunteers (54±3) performed aerobic exercise alternated with a series of weights exercises, for the analysis of blood pressure variation (by the oscillometric method) and pressure reactivity (by the Cold pressure test) before and after exercise. Results: The results demonstrated the occurrence of post-exercise hypotension in the systolic phase in the comparison between CC and C post-exercise (−11.65 mmHg). CC led to attenuation of 7mmHg and 4mmHg for SBP and DBP, respectively, in the blood pressure reactivity after one session. Conclusion: It is concluded that concurrent cross exercise ensures hypotension and positive reactivity of systolic blood pressure. Level of evidence II; Therapeutic studies-Investigating the results of treatment.

RESUMEN Introducción: La hipertensión arterial sistémica es una enfermedad que afecta principalmente a las mujeres. Objetivo: El presente estudio tuvo como objetivo verificar el efecto hipotensor y la reactividad de la presión arterial en mujeres sometidas a una sesión de ejercicio concurrente cruzado (CC). Métodos: Quince voluntarias (54 ± 3) realizaron ejercicio aeróbico alternando con una serie de ejercicios con peso para el análisis de la variación de la presión arterial (a través del método oscilométrico) y reactividad presórica (a través del Cold Pressure Test) pre y post ejercicio. Resultados: Los resultados demostraron la ocurrencia de hipotensión post ejercicio en la fase sistólica en comparación entre CC y C post ejercicio (−11,65mmHg). El CC provocó la atenuación de 7 mmHg y 4 mmHg para PAS y PAD, respectivamente, en la reactividad presórica después de una sesión. Conclusión: Se concluye que el ejercicio concurrente cruzado garantiza hipotensión y reactividad positiva de la presión arterial sistólica. Nivel de evidencia II; Estudios terapéuticos-Investigación de los resultados del tratamiento.

https://doi.org/10.1590/1517-869220202602219876 1059 downloads

10.

Exercise training improves quality of life in women with subclinical hypothyroidism: a randomized clinical trial
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Werneck, Francisco Zacaron

; Coelho, Emerson Filipino

; Almas, Saulo Peters

; Garcia, Marília Mendes do Nascimento

; Bonfante, Heloina Lamha Machado

; Lima, Jorge Roberto Perrout de

; Vigário, Patrícia dos Santos

; Mainenti, Míriam Raquel Meira

; Teixeira, Patrícia de Fátima dos Santos

; Vaisman, Mário

Archives of Endocrinology and Metabolism

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oct 2018, Volume 62 N. 5 Pages 530 - 536

Abstract: En | Text: En | PDF: En

ABSTRACT Objective: The aim was to evaluate the quality of life (HRQoL) in women with subclinical hypothyroidism (sHT) after 16 weeks of endurance training. Subjects and methods: In the first phase, a cross-sectional study was conducted in which 22 women with sHT (median age: 41.5 (interquartile range: 175) years, body mass index: 26.2 (8.7) kg/m2, thyroid stimulating hormone > 4.94 mIU/L and free thyroxine between 0.8 and 1.3 ng/dL were compared to a group of 33 euthyroid women concerned to HRQoL. In the second phase, a randomized clinical trial was conducted where only women with sHT were randomly divided into two groups: sHT-Tr (n = 10) - participants that performed an exercise program - and sHT-Sed (n = 10) - controls. Exercise training consisted of 60 minutes of aerobic activities (bike and treadmill), three times a week, for 16 weeks. The HRQoL was assessed by the SF-36 questionnaire in the early and at the end of four months. Results: Women with sHT had lower scores on functional capacity domain in relation to the euthyroid ones (770 ± 23.0 vs. 88.8 ± 14.6; p = 0.020). The sHT-Tr group improved functional capacity, general health, emotional aspects, mental and physical component of HRQoL after training period, while the sHT-Sed group showed no significant changes. Conclusion: After 16 weeks of aerobic exercise training, there were remarkable improvements in HRQoL in women with sHT.

https://doi.org/10.20945/2359-3997000000073 4516 downloads

11.

Reativation of Taxaquara Fault and its morphotectonic influence on the evolution of Jordão River catchment, Paraná, Brasil
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Peyerl, William Rudolf Lopes

; Salamuni, Eduardo

; Sanches, Emerson

; Nascimento, Edenilson Roberto do

; Santos, Jéssica Miranda

; Gimenez, Viviane Barbosa

; Silva, Clauzionor Lima da

; Farias, Taily Ferreira Santos

Brazilian Journal of Geology

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jul 2018, Volume 48 N. 3 Pages 553 - 573

Abstract: En | Text: En | PDF: En

ABSTRACT: The Paraná basin is one of the major morphotectures of the South American continent. Although its tectono-sedimentary evolution has been widely studied and fairly well understood, this paper aims to fill a gap in knowledge comprising the tectonic evolution after the end of its last sedimentary cycle, in the Upper Cretaceous. In this context, the Jordan River watershed, situated in the surroundings of Guarapuava municipality, south central region of Paraná State, was selected for structural and morphometric analysis where the Cretaceous volcanic rocks of Serra Geral Formation are exposed. The Jordan River watershed was studied for the influence exerted by Taxaquara Fault Zone on its morphologic evolution, since Taxaquara Fault Zone is associated to the Brazilian cycle and extends eastwards to the Ribeira belt in the state of São Paulo. The morphometric analysis consisted in the interpretation of the Jordan River watershed drainage network and relief elements, considering the distribution of existing knickpoints in the water courses. Structural analysis was based on the calculation of the stress fields responsible for the activation of local fault zones, which were determined by their spatial arrangement and the statistical and mechanical treatments of structural data. During the Oligocene and Miocene, erosional processes developed a planing surface which marks the relief in the central region of the Jordan River watershed and serves as a stratigraphic marker for the associated deformational events. Three events that contributed to the morphological framework of the Jordan River watershed were defined: an oldest one, probably active before the development of the Jordan pediplane in the Paleogene, by a NE-SW maximum horizontal stress (SHmax); and two more recent ones, being one of Plio-Pleistocene age, with a N05W SHmax, and a still active event of transtensive nature showing a N75W SHmax. The paleostress analysis points to a similarity between the Cenozoic evolution of Paraná Basin and the tafrogenic basins of southeast Brazil, revealing the amplitude of the deformation events associated to the studied period and ensuring the importance of further studies on the morphotectonic evolutions of intracratonic regions of the South American plate and their correlation to the Andean tectonic cycle.

https://doi.org/10.1590/2317-4889201820170110 1275 downloads

12.

Low cost UV-Ozone reactor mounted for treatment of electrode anodes used in P-OLEDs devices
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Santos, Emerson Roberto

; Moraes, José Igor Balbino de

; Takahashi, Christine Miwa

; Sonnenberg, Victor

; Burini, Elvo Calixto

; Yoshida, Satoru

; Takimoto, Herick Garcia

; Onmori, Roberto Koji

; Hui, Wang Shu

Polímeros

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sep 2016, Volume 26 N. 3 Pages 236 - 241

Abstract: En | Text: En | PDF: En

Abstract Low cost UV-Ozone reactor using a high pressure mercury vapor lamp of 80 watts without outer bulb showed good results for treatment of ITO films used as anode electrode in the assembly of P-OLED (polymer-organic light emitting diode) devices. This study revealed 20 minutes as effective treatment time and it was verified also that the effect of UV-Ozone treatment loses its efficiency as the elapsed time increases. It was analyzed with measurements of contact angle using a droplet of PEDOT:PSS polymer. P-OLEDs devices were mounted with architecture: ITO/PEDOT:PSS/PVK/Alq3/Al. The PVK polymer was diluted in organic solvent of 1,2,4-trichlorobenzene with concentrations of: 5, 10, 20 and 30 mg/mL. Results revealed better performance of P-OLED devices for concentration of 5 mg/mL resulting in lower threshold voltage, elevation of electrical current and similar diode curve.

https://doi.org/10.1590/0104-1428.2257 964 downloads

13.

Influência de diferentes solventes utilizados na deposição de filme de poli(9-vinilcarbazol) em dispositivos OLEDs
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Santos, Emerson Roberto

; Wang, Shu Hui

; Correia, Fabio Conte

; Costa, Ivan Rodrigues

; Sonnenberg, Victor

; Burini Junior, Elvo Calixto

; Onmori, Roberto Koji

Química Nova

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2014, Volume 37 N. 1 Pages 1 - 5

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

This work studies the influence of the film deposition process on light emission performance and on threshold voltage of OLEDs, with architecture glass/ITO/PEDOT:PSS/PVK/Alq3/Al. The commercial PVK was dissolved in different solvents such as: chloroform, tetrahydrofuran, 1,2,4-trichlorobenzene and trimethylpentane. OLEDs were characterized by current-voltage and revealed a significant influence of the solvents, although all devices emitted green electroluminescence. A difference in threshold voltage up to 10 V was observed among OLEDs prepared from different solvents. The 1,2,4-trichlorobenzene showed best performance, presenting lowest treshold voltage (≈ 6 V), followed by tetrahydrofuran (≈ 8 V), trimethylpentane (≈ 14 V) and chloroform (≈ 16 V).

2213 downloads Cited 1 time in SciELO

14.

Treinamento resistido controla a pressão arterial de ratos hipertensos induzidos por l-NAME
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Araujo, Ayslan Jorge Santos de

; Santos, Anne Carolline Veríssimo dos

; Souza, Karine dos Santos

; Aires, Marlúcia Bastos

; Santana-Filho, Valter Joviniano

; Fioretto, Emerson Ticona

; Mota, Marcelo Mendonça

; Santos, Márcio Roberto Viana

Arquivos Brasileiros de Cardiologia

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apr 2013, Volume 100 N. 4 Pages 339 - 346

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

FUNDAMENTO: A hipertensão arterial é uma síndrome multifatorial, crônica, causada tanto por fatores congênitos ou adquiridos. OBJETIVO: Avaliar os efeitos do treinamento físico resistido (TR) sobre pressão arterial, reatividade e morfologia vascular de ratos hipertensos induzidos por L-NAME. MÉTODOS: Ratos Wistar machos (200-250 g) foram divididos em 3 grupos: normotenso sedentário (NS), hipertenso sedentário (HS) e hipertenso treinado (HT). A hipertensão foi induzida pela administração de L-NAME (40 mg/kg) na água de beber por 4 semanas. A pressão arterial foi avaliada antes e após o TR. O TR foi realizado utilizando 50% de 1RM, em 3 séries de 10 repetições, 3 vezes por semana, durante quatro semanas. A reatividade vascular foi mensurada em artéria mesentérica superior por curvas concentração resposta ao nitroprussiato de sódio (NPS) e fenilefrina (FEN). Além disso, foram realizadas análises histológicas e estereológicas. RESULTADOS: O TR inibiu o aumento das pressões arteriais média e diastólica. Foi observada uma redução significativa na resposta máxima e na potência da FEN entre os grupos HS e HT. A análise histológica evidenciou aspecto normal para as túnicas íntima, média e adventícia em todos os grupos. Não houve diferença significativa nas áreas do lúmen, da túnica média e total das artérias dos grupos HS e HT em relação ao NS. A razão parede/lúmen arterial do grupo HS apresentou diferença significativa em relação ao NS (p < 0,05), mas esta não foi diferente do HT. CONCLUSÕES: O TR foi capaz de prevenir a elevação da pressão arterial sob as condições deste estudo. Este controle parece envolver a regulação de mecanismo vasoconstritor e a manutenção do diâmetro luminal de ratos hipertensos induzidos por L-NAME.

BACKGROUND: Arterial hypertension is a multifactorial chronic condition caused by either congenital or acquired factors. OBJECTIVE: To evaluate the effects of Resistance Training (RT) on arterial pressure, and on vascular reactivity and morphology, of L-NAME-treated hypertensive rats. METHODS: Male Wistar rats (200 - 250 g) were allocated into Sedentary Normotensive (SN), Sedentary Hypertensive (SH) and Trained Hypertensive (TH) groups. Hypertension was induced by adding L-NAME (40 mg/Kg) to the drinking water for four weeks. Arterial pressure was evaluated before and after RT. RT was performed using 50% of 1RM, 3 sets of 10 repetitions, 3 times per week for four weeks. Vascular reactivity was measured in rat mesenteric artery rings by concentration-response curves to sodium nitroprusside (SNP); phenylephrine (PHE) was also used for histological and stereological analysis. RESULTS: Resistance training inhibited the increase in mean and diastolic arterial pressures. Significant reduction was observed in Rmax (maximal response) and pD2 (potency) of PHE between SH and TH groups. Arteries demonstrated normal intima, media and adventitia layers in all groups. Stereological analysis demonstrated no significant difference in luminal, tunica media, and total areas of arteries in the SH and TH groups when compared to the SN group. Wall-to-lumen ratio of SH arteries was significantly different compared to SN arteries (p<0.05) but there was no difference when compared to TH arteries. CONCLUSIONS: RT was able to prevent an increase in blood pressure under the conditions in this study. This appears to involve a vasoconstrictor regulation mechanism and maintenance of luminal diameter in L-NAME induced hypertensive rats.

https://doi.org/10.5935/abc.20130051 6876 downloads

15.

Inorganic-organic hybrids based on poly (ε-Caprolactone) and silica oxide and characterization by relaxometry applying low-field NMR
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Monteiro, Mariana Sato de Souza de Bustamante

; Cucinelli Neto, Roberto Pinto

; Santos, Izabel Cristina Souza

; Silva, Emerson Oliveira da

; Tavares, Maria Inês Bruno

Materials Research

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dec 2012, Volume 15 N. 6 Pages 825 - 832

Abstract: En | Text: En | PDF: En

Poly (ε-caprolactone) (PCL) based hybrids containing different amounts of modified (Aerosil® R972) and unmodified (Aerosil® A200) silica oxide were prepared employing the solution method, using chloroform. The relationships of the amount of nanofillers, organic coating, molecular structure and intermolecular interaction of the hybrid materials were investigated mainly using low-field nuclear magnetic resonance (NMR). The NMR analyses involved the hydrogen spin-lattice relaxation time (T1H) and hydrogen spin-lattice relaxation time in the rotating frame (T1ρH). The spin-lattice relaxation time measurements revealed that the PCL/silica oxide hybrids were heterogeneous, meaning their components were well dispersed. X-ray diffraction (XRD), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) were also employed. The DSC data showed that all the materials had lower crystallization temperature (Tc) and melting temperature (Tm), so the crystallinity degree of the PCL decreased in the hybrids. The TGA analysis demonstrated that the addition of modified and unmodified silica oxide does not cause considerable changes to PCL's thermal stability, since no significant variations in the maximum temperature (Tmax) were observed in relation to the neat polymer.

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